                         SEQUENCE LISTING

<110>  The National Institute for Biotechnology in the Negev, LTD
 
<120>  FUSION PROTEINS WITH EXTENDED SERUM HALF LIFE

<130>  NIBN-P-010 PCT

<150>  USP 62/360524
<151>  2016-07-11

<150>  USP 62/421400
<151>  2016-11-14

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Trp Arg Ala Leu His Pro Leu Leu Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Pro Gly Ser Gln Ala Gln Ser Lys Ala Gln Val Leu Gln Ser Val Ala 
            20                  25                  30          


Gly Gln Thr Leu Thr Val Arg Cys Gln Tyr Pro Pro Thr Gly Ser Leu 
        35                  40                  45              


Tyr Glu Lys Lys Gly Trp Cys Lys Glu Ala Ser Ala Leu Val Cys Ile 
    50                  55                  60                  


Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Met Ala Trp Thr Ser Arg 
65                  70                  75                  80  


Phe Thr Ile Trp Asp Asp Pro Asp Ala Gly Phe Phe Thr Val Thr Met 
                85                  90                  95      


Thr Asp Leu Arg Glu Glu Asp Ser Gly His Tyr Trp Cys Arg Ile Tyr 
            100                 105                 110         


Arg Pro Ser Asp Asn Ser Val Ser Lys Ser Val Arg Phe Tyr Leu Val 
        115                 120                 125             


Val Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
    130                 135                 140                 


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
145                 150                 155                 160 


Gly Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
                165                 170                 175     


His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn 
            180                 185                 190         


Ser Thr Leu Arg Pro Gly Pro Ala Ala Pro Ile Ala Leu Val Pro Val 
        195                 200                 205             


Phe Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu Ser Ala Leu Leu 
    210                 215                 220                 


Val Trp Trp Val Leu Arg Asn Arg His Met Gln His Gln Gly Arg Ser 
225                 230                 235                 240 


Leu Leu His Pro Ala Gln Pro Arg Pro Gln Ala His Arg His Phe Pro 
                245                 250                 255     


Leu Ser His Arg Ala Pro Gly Gly Thr Tyr Gly Gly Lys Pro 
            260                 265                 270 


<210>  2
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His 
        35                  40                  45              


Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser 
    50                  55                  60                  


Thr Leu Arg Pro Gly Pro 
65                  70  


<210>  3
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg 
        


<210>  4
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro 
        35      


<210>  5
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His 
        35                  40                  45              


Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Ala Ser 
    50                  55                  60                  


Thr Leu Arg Pro Gly Pro 
65                  70  


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

His His His His His His His His 
1               5               


<210>  8
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro 
            20                  


<210>  9
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  10
<211>  173
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Trp Ser His Pro Gln Phe Glu Lys 
            20                  25                  30          


Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala Thr Leu Ala Val Glu Lys 
        35                  40                  45              


Glu Gly Cys Pro Val Cys Ile Thr Val Asn Thr Thr Ile Cys Ala Gly 
    50                  55                  60                  


Tyr Cys Pro Thr Met Thr Arg Val Leu Gln Gly Val Leu Pro Ala Leu 
65                  70                  75                  80  


Pro Gln Val Val Cys Asn Tyr Arg Asp Val Arg Phe Glu Ser Ile Arg 
                85                  90                  95      


Leu Pro Gly Cys Pro Arg Gly Val Asn Pro Val Val Ser Tyr Ala Val 
            100                 105                 110         


Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg Arg Ser Thr Thr Asp Cys 
        115                 120                 125             


Gly Gly Pro Lys Asp His Pro Leu Thr Cys Asp Asp Pro Arg Phe Gln 
    130                 135                 140                 


Asp Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser 
145                 150                 155                 160 


Arg Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
                165                 170             


<210>  11
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp 
    130                 135         


<210>  12
<211>  145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Trp Ser His Pro Gln Phe Glu Lys 
            20                  25                  30          


Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala Thr Leu Ala Val Glu Lys 
        35                  40                  45              


Glu Gly Cys Pro Val Cys Ile Thr Val Asn Thr Thr Ile Cys Ala Gly 
    50                  55                  60                  


Tyr Cys Pro Thr Met Thr Arg Val Leu Gln Gly Val Leu Pro Ala Leu 
65                  70                  75                  80  


Pro Gln Val Val Cys Asn Tyr Arg Asp Val Arg Phe Glu Ser Ile Arg 
                85                  90                  95      


Leu Pro Gly Cys Pro Arg Gly Val Asn Pro Val Val Ser Tyr Ala Val 
            100                 105                 110         


Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg Arg Ser Thr Thr Asp Cys 
        115                 120                 125             


Gly Gly Pro Lys Asp His Pro Leu Thr Cys Asp Asp Pro Arg Phe Gln 
    130                 135                 140                 


Asp 
145 


<210>  13
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Trp Ser His Pro Gln Phe Glu Lys 
            20                  25                  30          


Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala Thr Leu Ala Val Glu Lys 
        35                  40                  45              


Glu Gly Cys Pro Val Cys Ile Thr Val Asn Thr Thr Ile Cys Ala Gly 
    50                  55                  60                  


Tyr Cys Pro Thr Met Thr Arg Val Leu Gln Gly Val Leu Pro Ala Leu 
65                  70                  75                  80  


Pro Gln Val Val Cys Asn Tyr Arg Asp Val Arg Phe Glu Ser Ile Arg 
                85                  90                  95      


Leu Pro Gly Cys Pro Arg Gly Val Asn Pro Val Val Ser Tyr Ala Val 
            100                 105                 110         


Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg Arg Ser Thr Thr Asp Cys 
        115                 120                 125             


Gly Gly Pro Lys Asp His Pro Leu Thr Cys Asp Asp Pro Arg Phe Gln 
    130                 135                 140                 


Asp Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
145                 150                 155                 160 


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
                165                 170                 175     


Gly Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
            180                 185                 190         


His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn 
        195                 200                 205             


Ser Thr Leu Arg Pro Gly Pro 
    210                 215 


<210>  14
<211>  183
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Leu Arg Pro Arg Cys Arg Pro Ile Asn Ala Thr Leu Ala Val Glu Lys 
1               5                   10                  15      


Glu Gly Cys Pro Val Cys Ile Thr Val Asn Thr Thr Ile Cys Ala Gly 
            20                  25                  30          


Tyr Cys Pro Thr Met Thr Arg Val Leu Gln Gly Val Leu Pro Ala Leu 
        35                  40                  45              


Pro Gln Val Val Cys Asn Tyr Arg Asp Val Arg Phe Glu Ser Ile Arg 
    50                  55                  60                  


Leu Pro Gly Cys Pro Arg Gly Val Asn Pro Val Val Ser Tyr Ala Val 
65                  70                  75                  80  


Ala Leu Ser Cys Gln Cys Ala Leu Cys Arg Arg Ser Thr Thr Asp Cys 
                85                  90                  95      


Gly Gly Pro Lys Asp His Pro Leu Thr Cys Asp Asp Pro Arg Phe Gln 
            100                 105                 110         


Asp Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
        115                 120                 125             


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
    130                 135                 140                 


Gly Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
145                 150                 155                 160 


His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn 
                165                 170                 175     


Ser Thr Leu Arg Pro Gly Pro 
            180             


<210>  15
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe 
    210                 215         


<210>  16
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
            180                 185                 190     


<210>  17
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Gln Ala 
            20                  25          


<210>  18
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys 
            20          


<210>  19
<211>  239
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Asp Tyr Lys Asp His Asp 
            20                  25                  30          


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
        35                  40                  45              


Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
    50                  55                  60                  


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
65                  70                  75                  80  


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
                85                  90                  95      


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
            100                 105                 110         


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
        115                 120                 125             


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
    130                 135                 140                 


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
145                 150                 155                 160 


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
                165                 170                 175     


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
            180                 185                 190         


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
        195                 200                 205             


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
    210                 215                 220                 


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
225                 230                 235                 


<210>  20
<211>  247
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Asp Tyr Lys Asp His Asp 
            20                  25                  30          


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
        35                  40                  45              


Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
    50                  55                  60                  


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
65                  70                  75                  80  


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
                85                  90                  95      


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
            100                 105                 110         


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
        115                 120                 125             


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
    130                 135                 140                 


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
145                 150                 155                 160 


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
                165                 170                 175     


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
            180                 185                 190         


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
        195                 200                 205             


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
    210                 215                 220                 


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe His 
225                 230                 235                 240 


His His His His His His His 
                245         


<210>  21
<211>  269
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser 
            180                 185                 190         


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
        195                 200                 205             


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
    210                 215                 220                 


Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro 
225                 230                 235                 240 


Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr 
                245                 250                 255     


Leu Arg Pro Gly Pro His His His His His His His His 
            260                 265                 


<210>  22
<211>  225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met 
        35                  40                  45              


Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu 
    50                  55                  60                  


Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln 
65                  70                  75                  80  


Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser 
                85                  90                  95      


Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile 
            100                 105                 110         


Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg 
        115                 120                 125             


Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val 
    130                 135                 140                 


Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly 
145                 150                 155                 160 


Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr 
                165                 170                 175     


Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys 
            180                 185                 190         


Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu 
        195                 200                 205             


Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly 
    210                 215                 220                 


Phe 
225 


<210>  23
<211>  261
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser 
            180                 185                 190         


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
        195                 200                 205             


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
    210                 215                 220                 


Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro 
225                 230                 235                 240 


Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr 
                245                 250                 255     


Leu Arg Pro Gly Pro 
            260     


<210>  24
<211>  317
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Asp Tyr Lys Asp His Asp 
            20                  25                  30          


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
        35                  40                  45              


Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
    50                  55                  60                  


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
65                  70                  75                  80  


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
                85                  90                  95      


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
            100                 105                 110         


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
        115                 120                 125             


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
    130                 135                 140                 


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
145                 150                 155                 160 


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
                165                 170                 175     


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
            180                 185                 190         


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
        195                 200                 205             


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
    210                 215                 220                 


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser 
225                 230                 235                 240 


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
                245                 250                 255     


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
            260                 265                 270         


Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro 
        275                 280                 285             


Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Ala Ser Thr 
    290                 295                 300                 


Leu Arg Pro Gly Pro His His His His His His His His 
305                 310                 315         


<210>  25
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  25

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Asp Tyr Lys Asp His Asp 
            20                  25                  30          


Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
        35                  40                  45              


Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
    50                  55                  60                  


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
65                  70                  75                  80  


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
                85                  90                  95      


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
            100                 105                 110         


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
        115                 120                 125             


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
    130                 135                 140                 


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
145                 150                 155                 160 


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
                165                 170                 175     


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
            180                 185                 190         


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
        195                 200                 205             


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
    210                 215                 220                 


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser 
225                 230                 235                 240 


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
                245                 250                 255     


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
            260                 265                 270         


Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro 
        275                 280                 285             


Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Ala Ser Thr 
    290                 295                 300                 


Leu Arg Pro Gly Pro 
305                 


<210>  26
<211>  261
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser 
            180                 185                 190         


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
        195                 200                 205             


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
    210                 215                 220                 


Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro 
225                 230                 235                 240 


Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Ala Ser Thr 
                245                 250                 255     


Leu Arg Pro Gly Pro 
            260     


<210>  27
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  27

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Pro Ala Ser Ala Ser 
            20                  25                  30          


Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln 
        35                  40                  45              


Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Phe Pro Thr Ile 
    50                  55                  60                  


Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu 
65                  70                  75                  80  


His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile 
                85                  90                  95      


Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu 
            100                 105                 110         


Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln 
        115                 120                 125             


Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln 
    130                 135                 140                 


Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser 
145                 150                 155                 160 


Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp 
                165                 170                 175     


Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser 
            180                 185                 190         


Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr 
        195                 200                 205             


Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Pro Ala Ser Ala 
                245                 250                 255     


Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr 
            260                 265                 270         


Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg His His His 
        275                 280                 285             


His His His His His 
    290             


<210>  28
<211>  285
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  28

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Pro Ala Ser Ala Ser 
            20                  25                  30          


Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln 
        35                  40                  45              


Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Phe Pro Thr Ile 
    50                  55                  60                  


Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu 
65                  70                  75                  80  


His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile 
                85                  90                  95      


Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu 
            100                 105                 110         


Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln 
        115                 120                 125             


Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln 
    130                 135                 140                 


Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser 
145                 150                 155                 160 


Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp 
                165                 170                 175     


Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser 
            180                 185                 190         


Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr 
        195                 200                 205             


Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Pro Ala Ser Ala 
                245                 250                 255     


Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr 
            260                 265                 270         


Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg 
        275                 280                 285 


<210>  29
<211>  259
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  29

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met 
        35                  40                  45              


Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu 
    50                  55                  60                  


Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln 
65                  70                  75                  80  


Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser 
                85                  90                  95      


Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile 
            100                 105                 110         


Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg 
        115                 120                 125             


Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val 
    130                 135                 140                 


Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly 
145                 150                 155                 160 


Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr 
                165                 170                 175     


Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys 
            180                 185                 190         


Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu 
        195                 200                 205             


Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly 
    210                 215                 220                 


Phe Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
225                 230                 235                 240 


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
                245                 250                 255     


Gly Ala Arg 
            


<210>  30
<211>  259
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  30

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Pro Ala Ser Ala Ser Thr 
    210                 215                 220                 


Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr 
225                 230                 235                 240 


Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg His His His His His 
                245                 250                 255     


His His His 
            


<210>  31
<211>  251
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  31

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Pro Ala Ser Ala Ser Thr 
    210                 215                 220                 


Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr 
225                 230                 235                 240 


Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg 
                245                 250     


<210>  32
<211>  225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  32

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser 
            180                 185                 190         


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
        195                 200                 205             


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
    210                 215                 220                 


Arg 
225 


<210>  33
<211>  261
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  33

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro Glu Ser Pro Ser 
    210                 215                 220                 


Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu 
225                 230                 235                 240 


Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro His His His 
                245                 250                 255     


His His His His His 
            260     


<210>  34
<211>  253
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  34

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe 
            180                 185                 190         


Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys 
        195                 200                 205             


Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro Glu Ser Pro Ser 
    210                 215                 220                 


Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu 
225                 230                 235                 240 


Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
                245                 250             


<210>  35
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  35

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr 
145                 150                 155                 160 


Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe 
                165                 170                 175     


Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gln 
            180                 185                 190         


Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser 
        195                 200                 205             


Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg 
    210                 215                 220                 


Pro Gly Pro 
225         


<210>  36
<211>  295
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  36

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Pro Ala Ser Ala Ser 
            20                  25                  30          


Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln 
        35                  40                  45              


Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Phe Pro Thr Ile 
    50                  55                  60                  


Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu 
65                  70                  75                  80  


His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile 
                85                  90                  95      


Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu 
            100                 105                 110         


Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln 
        115                 120                 125             


Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln 
    130                 135                 140                 


Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser 
145                 150                 155                 160 


Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp 
                165                 170                 175     


Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser 
            180                 185                 190         


Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr 
        195                 200                 205             


Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro Glu Ser 
                245                 250                 255     


Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val 
            260                 265                 270         


Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro His 
        275                 280                 285             


His His His His His His His 
    290                 295 


<210>  37
<211>  287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  37

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Pro Ala Ser Ala Ser 
            20                  25                  30          


Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln 
        35                  40                  45              


Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Phe Pro Thr Ile 
    50                  55                  60                  


Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu 
65                  70                  75                  80  


His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile 
                85                  90                  95      


Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu 
            100                 105                 110         


Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln 
        115                 120                 125             


Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln 
    130                 135                 140                 


Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser 
145                 150                 155                 160 


Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp 
                165                 170                 175     


Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser 
            180                 185                 190         


Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr 
        195                 200                 205             


Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro Glu Ser 
                245                 250                 255     


Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val 
            260                 265                 270         


Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
        275                 280                 285         


<210>  38
<211>  261
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  38

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met 
        35                  40                  45              


Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu 
    50                  55                  60                  


Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln 
65                  70                  75                  80  


Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser 
                85                  90                  95      


Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile 
            100                 105                 110         


Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg 
        115                 120                 125             


Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val 
    130                 135                 140                 


Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly 
145                 150                 155                 160 


Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr 
                165                 170                 175     


Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys 
            180                 185                 190         


Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu 
        195                 200                 205             


Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly 
    210                 215                 220                 


Phe Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro 
225                 230                 235                 240 


Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr 
                245                 250                 255     


Leu Arg Pro Gly Pro 
            260     


<210>  39
<211>  295
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  39

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Gln Ala Pro Glu Ser Pro 
            20                  25                  30          


Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro 
        35                  40                  45              


Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Phe Pro 
    50                  55                  60                  


Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His 
65                  70                  75                  80  


Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala 
                85                  90                  95      


Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr 
            100                 105                 110         


Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu 
        115                 120                 125             


Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu 
    130                 135                 140                 


Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala 
145                 150                 155                 160 


Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu 
                165                 170                 175     


Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp 
            180                 185                 190         


Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe 
        195                 200                 205             


Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Pro Ala 
                245                 250                 255     


Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser 
            260                 265                 270         


Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg His 
        275                 280                 285             


His His His His His His His 
    290                 295 


<210>  40
<211>  287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  40

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Gln Ala Pro Glu Ser Pro 
            20                  25                  30          


Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro 
        35                  40                  45              


Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Phe Pro 
    50                  55                  60                  


Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His 
65                  70                  75                  80  


Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala 
                85                  90                  95      


Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr 
            100                 105                 110         


Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu 
        115                 120                 125             


Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu 
    130                 135                 140                 


Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala 
145                 150                 155                 160 


Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu 
                165                 170                 175     


Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp 
            180                 185                 190         


Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe 
        195                 200                 205             


Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Pro Ala 
                245                 250                 255     


Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser 
            260                 265                 270         


Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg 
        275                 280                 285         


<210>  41
<211>  261
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  41

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn 
        35                  40                  45              


Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr 
    50                  55                  60                  


Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe 
65                  70                  75                  80  


Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr 
                85                  90                  95      


Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu 
            100                 105                 110         


Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe 
        115                 120                 125             


Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser 
    130                 135                 140                 


Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu 
145                 150                 155                 160 


Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys 
                165                 170                 175     


Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu 
            180                 185                 190         


Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys 
        195                 200                 205             


Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser 
    210                 215                 220                 


Cys Gly Phe Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro 
225                 230                 235                 240 


Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro 
                245                 250                 255     


Thr Ala Gly Ala Arg 
            260     


<210>  42
<211>  297
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  42

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Gln Ala Pro Glu Ser Pro 
            20                  25                  30          


Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro 
        35                  40                  45              


Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Phe Pro 
    50                  55                  60                  


Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His 
65                  70                  75                  80  


Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala 
                85                  90                  95      


Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr 
            100                 105                 110         


Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu 
        115                 120                 125             


Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu 
    130                 135                 140                 


Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala 
145                 150                 155                 160 


Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu 
                165                 170                 175     


Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp 
            180                 185                 190         


Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe 
        195                 200                 205             


Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro 
                245                 250                 255     


Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu 
            260                 265                 270         


Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly 
        275                 280                 285             


Pro His His His His His His His His 
    290                 295         


<210>  43
<211>  289
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  43

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Gln Ala Pro Glu Ser Pro 
            20                  25                  30          


Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro 
        35                  40                  45              


Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Phe Pro 
    50                  55                  60                  


Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His 
65                  70                  75                  80  


Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala 
                85                  90                  95      


Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr 
            100                 105                 110         


Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu 
        115                 120                 125             


Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu 
    130                 135                 140                 


Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala 
145                 150                 155                 160 


Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu 
                165                 170                 175     


Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp 
            180                 185                 190         


Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe 
        195                 200                 205             


Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro 
                245                 250                 255     


Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu 
            260                 265                 270         


Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly 
        275                 280                 285             


Pro 
    


<210>  44
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  44

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn 
        35                  40                  45              


Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr 
    50                  55                  60                  


Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe 
65                  70                  75                  80  


Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr 
                85                  90                  95      


Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu 
            100                 105                 110         


Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe 
        115                 120                 125             


Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser 
    130                 135                 140                 


Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu 
145                 150                 155                 160 


Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys 
                165                 170                 175     


Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu 
            180                 185                 190         


Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys 
        195                 200                 205             


Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser 
    210                 215                 220                 


Cys Gly Phe Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
225                 230                 235                 240 


His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn 
                245                 250                 255     


Ser Thr Leu Arg Pro Gly Pro 
            260             


<210>  45
<211>  333
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  45

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Gln Ala Pro Glu Ser Pro 
            20                  25                  30          


Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro 
        35                  40                  45              


Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Phe Pro 
    50                  55                  60                  


Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His 
65                  70                  75                  80  


Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala 
                85                  90                  95      


Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr 
            100                 105                 110         


Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu 
        115                 120                 125             


Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu 
    130                 135                 140                 


Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala 
145                 150                 155                 160 


Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu 
                165                 170                 175     


Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp 
            180                 185                 190         


Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe 
        195                 200                 205             


Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro 
                245                 250                 255     


Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu 
            260                 265                 270         


Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly 
        275                 280                 285             


Pro Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro 
    290                 295                 300                 


Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr 
305                 310                 315                 320 


Leu Arg Pro Gly Pro His His His His His His His His 
                325                 330             


<210>  46
<211>  325
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  46

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Gln Ala Pro Glu Ser Pro 
            20                  25                  30          


Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro 
        35                  40                  45              


Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Phe Pro 
    50                  55                  60                  


Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His 
65                  70                  75                  80  


Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala 
                85                  90                  95      


Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr 
            100                 105                 110         


Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu 
        115                 120                 125             


Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu 
    130                 135                 140                 


Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala 
145                 150                 155                 160 


Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu 
                165                 170                 175     


Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp 
            180                 185                 190         


Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe 
        195                 200                 205             


Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro 
                245                 250                 255     


Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu 
            260                 265                 270         


Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly 
        275                 280                 285             


Pro Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro 
    290                 295                 300                 


Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr 
305                 310                 315                 320 


Leu Arg Pro Gly Pro 
                325 


<210>  47
<211>  299
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  47

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn 
        35                  40                  45              


Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr 
    50                  55                  60                  


Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe 
65                  70                  75                  80  


Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr 
                85                  90                  95      


Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu 
            100                 105                 110         


Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe 
        115                 120                 125             


Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser 
    130                 135                 140                 


Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu 
145                 150                 155                 160 


Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys 
                165                 170                 175     


Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu 
            180                 185                 190         


Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys 
        195                 200                 205             


Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser 
    210                 215                 220                 


Cys Gly Phe Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
225                 230                 235                 240 


His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn 
                245                 250                 255     


Ser Thr Leu Arg Pro Gly Pro Gln Ala Pro Glu Ser Pro Ser Thr Ile 
            260                 265                 270         


Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser 
        275                 280                 285             


Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
    290                 295                 


<210>  48
<211>  331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  48

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Pro Ala Ser Ala Ser 
            20                  25                  30          


Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln 
        35                  40                  45              


Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Phe Pro Thr Ile 
    50                  55                  60                  


Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu 
65                  70                  75                  80  


His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile 
                85                  90                  95      


Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu 
            100                 105                 110         


Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln 
        115                 120                 125             


Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln 
    130                 135                 140                 


Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser 
145                 150                 155                 160 


Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp 
                165                 170                 175     


Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser 
            180                 185                 190         


Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr 
        195                 200                 205             


Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro Glu Ser 
                245                 250                 255     


Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val 
            260                 265                 270         


Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Gln 
        275                 280                 285             


Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser 
    290                 295                 300                 


Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg 
305                 310                 315                 320 


Pro Gly Pro His His His His His His His His 
                325                 330     


<210>  49
<211>  323
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  49

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Pro Ala Ser Ala Ser 
            20                  25                  30          


Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln 
        35                  40                  45              


Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Phe Pro Thr Ile 
    50                  55                  60                  


Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu 
65                  70                  75                  80  


His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile 
                85                  90                  95      


Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu 
            100                 105                 110         


Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln 
        115                 120                 125             


Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln 
    130                 135                 140                 


Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser 
145                 150                 155                 160 


Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp 
                165                 170                 175     


Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser 
            180                 185                 190         


Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr 
        195                 200                 205             


Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Gln Ala Pro Glu Ser 
                245                 250                 255     


Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val 
            260                 265                 270         


Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Gln 
        275                 280                 285             


Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser 
    290                 295                 300                 


Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg 
305                 310                 315                 320 


Pro Gly Pro 
            


<210>  50
<211>  297
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  50

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met 
        35                  40                  45              


Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu 
    50                  55                  60                  


Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln 
65                  70                  75                  80  


Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser 
                85                  90                  95      


Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile 
            100                 105                 110         


Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg 
        115                 120                 125             


Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val 
    130                 135                 140                 


Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly 
145                 150                 155                 160 


Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr 
                165                 170                 175     


Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys 
            180                 185                 190         


Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu 
        195                 200                 205             


Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly 
    210                 215                 220                 


Phe Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro 
225                 230                 235                 240 


Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr 
                245                 250                 255     


Leu Arg Pro Gly Pro Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val 
            260                 265                 270         


Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro 
        275                 280                 285             


Gln Asn Ser Thr Leu Arg Pro Gly Pro 
    290                 295         


<210>  51
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  51

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Pro Ala Ser Ala Ser 
            20                  25                  30          


Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln 
        35                  40                  45              


Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Phe Pro Thr Ile 
    50                  55                  60                  


Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu 
65                  70                  75                  80  


His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile 
                85                  90                  95      


Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu 
            100                 105                 110         


Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln 
        115                 120                 125             


Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln 
    130                 135                 140                 


Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser 
145                 150                 155                 160 


Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp 
                165                 170                 175     


Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser 
            180                 185                 190         


Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr 
        195                 200                 205             


Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Pro Ala Ser Ala 
                245                 250                 255     


Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr 
            260                 265                 270         


Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Ser Pro Ala 
        275                 280                 285             


Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser 
    290                 295                 300                 


Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg His 
305                 310                 315                 320 


His His His His His His His 
                325         


<210>  52
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  52

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met 
        35                  40                  45              


Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu 
    50                  55                  60                  


Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln 
65                  70                  75                  80  


Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser 
                85                  90                  95      


Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile 
            100                 105                 110         


Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg 
        115                 120                 125             


Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val 
    130                 135                 140                 


Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly 
145                 150                 155                 160 


Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr 
                165                 170                 175     


Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys 
            180                 185                 190         


Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu 
        195                 200                 205             


Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly 
    210                 215                 220                 


Phe Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
225                 230                 235                 240 


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
                245                 250                 255     


Gly Ala Arg Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro 
            260                 265                 270         


Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro 
        275                 280                 285             


Thr Ala Gly Ala Arg 
    290             


<210>  53
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  53

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg 
        35                  40                  45              


Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr 
    50                  55                  60                  


Ala Gly Ala Arg Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn 
65                  70                  75                  80  


Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr 
                85                  90                  95      


Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe 
            100                 105                 110         


Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr 
        115                 120                 125             


Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu 
    130                 135                 140                 


Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe 
145                 150                 155                 160 


Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser 
                165                 170                 175     


Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu 
            180                 185                 190         


Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys 
        195                 200                 205             


Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu 
    210                 215                 220                 


Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys 
225                 230                 235                 240 


Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser 
                245                 250                 255     


Cys Gly Phe Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro 
            260                 265                 270         


Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro 
        275                 280                 285             


Thr Ala Gly Ala Arg Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp 
    290                 295                 300                 


Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val 
305                 310                 315                 320 


Pro Pro Thr Ala Gly Ala Arg 
                325         


<210>  54
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  54

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Gln Ala Pro Glu Ser Pro 
            20                  25                  30          


Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro 
        35                  40                  45              


Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Phe Pro 
    50                  55                  60                  


Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His 
65                  70                  75                  80  


Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala 
                85                  90                  95      


Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr 
            100                 105                 110         


Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu 
        115                 120                 125             


Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu 
    130                 135                 140                 


Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala 
145                 150                 155                 160 


Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu 
                165                 170                 175     


Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp 
            180                 185                 190         


Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe 
        195                 200                 205             


Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Pro Ala 
                245                 250                 255     


Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser 
            260                 265                 270         


Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Ser 
        275                 280                 285             


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
    290                 295                 300                 


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
305                 310                 315                 320 


Arg His His His His His His His His 
                325                 


<210>  55
<211>  321
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  55

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Gln Ala Pro Glu Ser Pro 
            20                  25                  30          


Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro 
        35                  40                  45              


Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro Phe Pro 
    50                  55                  60                  


Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His 
65                  70                  75                  80  


Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala 
                85                  90                  95      


Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr 
            100                 105                 110         


Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu 
        115                 120                 125             


Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu 
    130                 135                 140                 


Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala 
145                 150                 155                 160 


Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu 
                165                 170                 175     


Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp 
            180                 185                 190         


Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe 
        195                 200                 205             


Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe Ser Pro Ala 
                245                 250                 255     


Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser 
            260                 265                 270         


Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Ser 
        275                 280                 285             


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
    290                 295                 300                 


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
305                 310                 315                 320 


Arg 
    


<210>  56
<211>  295
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  56

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn 
        35                  40                  45              


Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr 
    50                  55                  60                  


Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe 
65                  70                  75                  80  


Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr 
                85                  90                  95      


Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu 
            100                 105                 110         


Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe 
        115                 120                 125             


Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser 
    130                 135                 140                 


Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu 
145                 150                 155                 160 


Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys 
                165                 170                 175     


Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu 
            180                 185                 190         


Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys 
        195                 200                 205             


Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser 
    210                 215                 220                 


Cys Gly Phe Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro 
225                 230                 235                 240 


Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro 
                245                 250                 255     


Thr Ala Gly Ala Arg Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp 
            260                 265                 270         


Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val 
        275                 280                 285             


Pro Pro Thr Ala Gly Ala Arg 
    290                 295 


<210>  57
<211>  259
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  57

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
            180                 185                 190         


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
        195                 200                 205             


Arg Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe His His His His His 
                245                 250                 255     


His His His 
            


<210>  58
<211>  251
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  58

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser 
                165                 170                 175     


Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val 
            180                 185                 190         


Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala 
        195                 200                 205             


Arg Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
                245                 250     


<210>  59
<211>  261
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  59

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Gln 
                165                 170                 175     


Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser 
            180                 185                 190         


Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg 
        195                 200                 205             


Pro Gly Pro Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe His His His 
                245                 250                 255     


His His His His His 
            260     


<210>  60
<211>  253
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  60

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys 
                85                  90                  95      


Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp 
            100                 105                 110         


Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val 
        115                 120                 125             


Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu 
    130                 135                 140                 


Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg 
145                 150                 155                 160 


Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Gln 
                165                 170                 175     


Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser 
            180                 185                 190         


Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg 
        195                 200                 205             


Pro Gly Pro Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg 
225                 230                 235                 240 


Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe 
                245                 250             


<210>  61
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  61

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Asn Arg 
    50                  55                  60                  


Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val 
                85                  90                  95      


Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp 
            100                 105                 110         


Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu 
        115                 120                 125             


Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser 
    130                 135                 140                 


Lys Phe Asp Thr Asn Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val 
145                 150                 155                 160 


Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro 
                165                 170                 175     


Gln Asn Ser Thr Leu Arg Pro Gly Pro Ser His Asn Asp Asp Ala Leu 
            180                 185                 190         


Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys 
        195                 200                 205             


Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser 
    210                 215                 220                 


Cys Gly Phe 
225         


<210>  62
<211>  227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  62

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Gln Ala Pro 
    50                  55                  60                  


Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu 
65                  70                  75                  80  


Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly 
                85                  90                  95      


Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu 
            100                 105                 110         


Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe 
        115                 120                 125             


Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser 
    130                 135                 140                 


Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu 
145                 150                 155                 160 


Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys 
                165                 170                 175     


Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu 
            180                 185                 190         


Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys 
        195                 200                 205             


Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser 
    210                 215                 220                 


Cys Gly Phe 
225         


<210>  63
<211>  259
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  63

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Phe Pro Thr Ile Pro Leu 
            20                  25                  30          


Ser Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln 
        35                  40                  45              


Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys 
    50                  55                  60                  


Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe 
65                  70                  75                  80  


Ser Glu Ser Ile Pro Thr Pro Ser Pro Ala Ser Ala Ser Thr Gln Thr 
                85                  90                  95      


Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser 
            100                 105                 110         


Cys Val Pro Pro Thr Ala Gly Ala Arg Ser Asn Arg Glu Glu Thr Gln 
        115                 120                 125             


Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln 
    130                 135                 140                 


Ser Trp Leu Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser 
145                 150                 155                 160 


Leu Val Tyr Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp 
                165                 170                 175     


Leu Glu Glu Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser 
            180                 185                 190         


Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr 
        195                 200                 205             


Asn Ser His Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr 
    210                 215                 220                 


Cys Phe Arg Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val 
225                 230                 235                 240 


Gln Cys Arg Ser Val Glu Gly Ser Cys Gly Phe His His His His His 
                245                 250                 255     


His His His 
            


<210>  64
<211>  225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  64

Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn Ala Met Leu Arg 
1               5                   10                  15      


Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr Gln Glu Phe Glu 
            20                  25                  30          


Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe Leu Gln Asn Pro 
        35                  40                  45              


Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr Pro Ser Pro Ala 
    50                  55                  60                  


Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser 
65                  70                  75                  80  


Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Ser 
                85                  90                  95      


Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu Arg Ile 
            100                 105                 110         


Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe Leu Arg 
        115                 120                 125             


Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser Asn Val 
    130                 135                 140                 


Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu Met Gly 
145                 150                 155                 160 


Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys Gln Thr 
                165                 170                 175     


Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu Leu Lys 
            180                 185                 190         


Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys Val Glu 
        195                 200                 205             


Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser Cys Gly 
    210                 215                 220                 


Phe 
225 


<210>  65
<211>  240
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  65

Met Tyr Arg Met Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val 
1               5                   10                  15      


Thr Asn Gly Ser Ala Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp 
            20                  25                  30          


Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val 
        35                  40                  45              


Pro Pro Thr Ala Gly Ala Arg Ala Pro Thr Ser Ser Ser Thr Lys Lys 
    50                  55                  60                  


Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu 
65                  70                  75                  80  


Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr 
                85                  90                  95      


Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln 
            100                 105                 110         


Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala 
        115                 120                 125             


Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile 
    130                 135                 140                 


Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys 
145                 150                 155                 160 


Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp 
                165                 170                 175     


Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gln Ala Pro Glu 
            180                 185                 190         


Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro 
        195                 200                 205             


Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
    210                 215                 220                 


Leu Glu Val Leu Phe Gln Gly Pro His His His His His His His His 
225                 230                 235                 240 


<210>  66
<211>  203
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  66

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
        35                  40                  45              


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
    50                  55                  60                  


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
65                  70                  75                  80  


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
                85                  90                  95      


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
            100                 105                 110         


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
        115                 120                 125             


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
    130                 135                 140                 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
145                 150                 155                 160 


Ser Ile Ile Ser Thr Leu Thr Gln Ala Pro Glu Ser Pro Ser Thr Ile 
                165                 170                 175     


Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser 
            180                 185                 190         


Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
        195                 200             


<210>  67
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  67

Met Tyr Arg Met Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val 
1               5                   10                  15      


Thr Asn Gly Ser Ala Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val 
            20                  25                  30          


Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro 
        35                  40                  45              


Gln Asn Ser Thr Leu Arg Pro Gly Pro Ala Pro Thr Ser Ser Ser Thr 
    50                  55                  60                  


Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met 
65                  70                  75                  80  


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
                85                  90                  95      


Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
            100                 105                 110         


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
        115                 120                 125             


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
    130                 135                 140                 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
145                 150                 155                 160 


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
                165                 170                 175     


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gln Ala 
            180                 185                 190         


Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro 
        195                 200                 205             


Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro 
    210                 215                 220                 


Gly Pro Leu Glu Val Leu Phe Gln Gly Pro His His His His His His 
225                 230                 235                 240 


His His 
        


<210>  68
<211>  205
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  68

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
        35                  40                  45              


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
    50                  55                  60                  


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
65                  70                  75                  80  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
                85                  90                  95      


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
            100                 105                 110         


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
        115                 120                 125             


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
    130                 135                 140                 


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
145                 150                 155                 160 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gln Ala Pro Glu Ser Pro Ser 
                165                 170                 175     


Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu 
            180                 185                 190         


Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
        195                 200                 205 


<210>  69
<211>  238
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  69

Met Tyr Arg Met Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu Val 
1               5                   10                  15      


Thr Asn Gly Ser Ala Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp 
            20                  25                  30          


Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val 
        35                  40                  45              


Pro Pro Thr Ala Gly Ala Arg Ala Pro Thr Ser Ser Ser Thr Lys Lys 
    50                  55                  60                  


Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu 
65                  70                  75                  80  


Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr 
                85                  90                  95      


Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln 
            100                 105                 110         


Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala 
        115                 120                 125             


Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile 
    130                 135                 140                 


Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys 
145                 150                 155                 160 


Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp 
                165                 170                 175     


Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Pro Ala Ser 
            180                 185                 190         


Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln 
        195                 200                 205             


Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg Leu Glu 
    210                 215                 220                 


Val Leu Phe Gln Gly Pro His His His His His His His His 
225                 230                 235             


<210>  70
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  70

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
        35                  40                  45              


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
    50                  55                  60                  


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
65                  70                  75                  80  


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
                85                  90                  95      


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
            100                 105                 110         


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
        115                 120                 125             


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
    130                 135                 140                 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
145                 150                 155                 160 


Ser Ile Ile Ser Thr Leu Thr Ser Pro Ala Ser Ala Ser Thr Gln Thr 
                165                 170                 175     


Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser 
            180                 185                 190         


Cys Val Pro Pro Thr Ala Gly Ala Arg 
        195                 200     


<210>  71
<211>  293
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  71

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg 
        35                  40                  45              


Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr 
    50                  55                  60                  


Ala Gly Ala Arg Phe Pro Thr Ile Pro Leu Ser Arg Leu Phe Asp Asn 
65                  70                  75                  80  


Ala Met Leu Arg Ala His Arg Leu His Gln Leu Ala Phe Asp Thr Tyr 
                85                  90                  95      


Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu Gln Lys Tyr Ser Phe 
            100                 105                 110         


Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser Glu Ser Ile Pro Thr 
        115                 120                 125             


Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser Asn Leu Glu Leu Leu 
    130                 135                 140                 


Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu Pro Val Gln Phe 
145                 150                 155                 160 


Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr Gly Ala Ser Asp Ser 
                165                 170                 175     


Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu Gly Ile Gln Thr Leu 
            180                 185                 190         


Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr Gly Gln Ile Phe Lys 
        195                 200                 205             


Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His Asn Asp Asp Ala Leu 
    210                 215                 220                 


Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg Lys Asp Met Asp Lys 
225                 230                 235                 240 


Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg Ser Val Glu Gly Ser 
                245                 250                 255     


Cys Gly Phe Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro 
            260                 265                 270         


Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro 
        275                 280                 285             


Thr Ala Gly Ala Arg 
    290             


