                     LISTAGEM DE SEQUNCIAS

<110>  Universidade Fedaral de Minas Gerais; Instituto Butantam
 
<120>  MTODO E KIT PARA DIAGNSTICO DA LEISHMANIOSE VISCERAL UTILIZANDO
        PROTENAS ANTIGNICASDE LEISHMANIA INFANTUM

<130>  NI 32/2016

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  975
<212>  PRT
<213>  Leishmania infantum

<400>  1

Met Gln Pro Ile Asn Pro Asn Asp Arg Ser Thr Gln Ala Gln Phe Val 
1               5                   10                  15      


Glu Val Ala Cys Arg Ala Ala Ser Pro Asn Pro Ala Val Arg Thr Pro 
            20                  25                  30          


Ala Glu Arg Glu Leu Leu Ala Phe Leu Asp Ser Val Asp Gln Gln Ser 
        35                  40                  45              


Gly Leu Pro Gln Leu Leu Leu Glu Leu Thr His Ser Glu Thr Pro His 
    50                  55                  60                  


Gly Ala Phe Phe Ala Ile Ser Phe Lys Asn Met Val Lys Lys Cys Trp 
65                  70                  75                  80  


Asp Pro Thr Thr Ser Glu His Cys Ile Gln Glu Cys Asp Lys Ala Ala 
                85                  90                  95      


Val Arg Gly Thr Ile Ile Glu Val Met Leu Arg Ser Ser Gly Ala Val 
            100                 105                 110         


Gln Arg Asn Leu Ala Glu Gly Ile Ala Leu Ile Ala Gln Val Asp Phe 
        115                 120                 125             


Pro Thr Ala Trp Pro Asp Ala Leu Ser Leu Ile Val Lys Val Leu Thr 
    130                 135                 140                 


Ser Gly Asn Asp Val Ala Gln Leu Arg Ala Ala Leu Ser Thr Ser His 
145                 150                 155                 160 


Ser Val Leu Arg Lys Tyr Arg His Gln Gly Glu Leu Thr Glu Thr Leu 
                165                 170                 175     


Val Gln Glu Leu Arg Ala Ile Tyr Ser Leu Leu Cys Pro Ala Leu Val 
            180                 185                 190         


Arg Ser Ile Glu Ser Leu Leu Ser Thr Leu Gly Thr Gln Gly Thr Asn 
        195                 200                 205             


Leu Thr Glu Val Tyr Arg Gly Ile Thr Asp Ala Val Glu Cys Leu Arg 
    210                 215                 220                 


Asp Ile Thr Ser Leu Asp Leu Gly Asp Glu Phe Ile Glu Arg Ile Gly 
225                 230                 235                 240 


Ser Ile Val Ser Met Tyr Asn Gln Cys Leu Thr Thr Val Met Ala Gln 
                245                 250                 255     


Ser Ala Leu Cys Gly Gly His Ala Ser Ala Met Ile Glu Met Asn Ser 
            260                 265                 270         


Ala Val Ile Ala Cys Met Thr His Trp Leu Asn Ser Phe Asp Glu Asp 
        275                 280                 285             


Phe Glu Asn Phe Ala Pro Gln Phe Ile Glu Val Val Ile Gly Met Leu 
    290                 295                 300                 


Ala Ser His Met Ser Ser Asp Leu Ser Met Asp Asp Leu Ala Val Cys 
305                 310                 315                 320 


Cys Leu Glu Leu Val Ser Ser Ala Cys Arg Gly Thr Thr Arg Ser His 
                325                 330                 335     


Leu Asn Thr Arg Glu Lys Leu Gln Tyr Ile Leu Gln Phe Ile Ile Leu 
            340                 345                 350         


Pro Asn Leu Ala Leu Cys Glu Asp Asp Leu Asp Thr Tyr Thr Ser Asp 
        355                 360                 365             


Pro Asp Glu Tyr Val Lys Arg Asn Met Glu Gly Ser Asn Phe His Thr 
    370                 375                 380                 


Arg Arg Arg Ala Ala Val Glu Leu Val Arg Ser Leu Leu Leu Tyr Leu 
385                 390                 395                 400 


Pro Glu Val Ala Arg Pro Leu Leu Ala Glu Val Thr Thr Glu Leu Leu 
                405                 410                 415     


Arg Thr Ala His Gly Asp Trp Arg Ala Lys Asp Thr Ala Ile Tyr Leu 
            420                 425                 430         


Ala Phe Val Leu Val Val Asp Gly Gln Leu Val Asn Thr Gln Arg Gly 
        435                 440                 445             


Val Thr Ala Gln Gln Leu Ser Asp Val Ile Pro Val Ala Gln Ile Leu 
    450                 455                 460                 


Glu Gly His Val Phe Pro Glu Ile Arg Cys Asp Leu Ser Ala Gln Ser 
465                 470                 475                 480 


Pro Gly Ile Val Lys Ala Asp Cys Met Leu Val Val Ala Ala Phe Arg 
                485                 490                 495     


Tyr Leu Ile Ala Pro Ser Ala Tyr Glu Phe Leu Val Pro Ala Leu Thr 
            500                 505                 510         


His His Ile Ala Val Gly Asp Ala Val Val Met Thr Tyr Ala Ala His 
        515                 520                 525             


Thr Leu Lys Cys Phe Leu Ser Val Thr Glu Ala Pro Ala Ala Ala Ala 
    530                 535                 540                 


Ile Glu Ala Val Phe Thr Gly Asn Thr Ile Ser Ile Leu Glu Gly Leu 
545                 550                 555                 560 


Cys Val Arg Ile Gln Gly Glu Glu Thr Pro Asn Pro Tyr Leu Met Gln 
                565                 570                 575     


Tyr Leu Met Ser Met Cys Phe Arg Phe Pro Lys Leu Val Ala Pro Phe 
            580                 585                 590         


Ala Thr Gln Val Ile Ala Ser Leu His Thr Pro Leu Tyr Arg Ala Val 
        595                 600                 605             


Arg Asn Pro Ser Asn Ala Leu Tyr Ser Gln Cys Met Phe Glu Val Ile 
    610                 615                 620                 


Ser Lys Cys Val Ala Leu Gln Pro Gly Ala Arg Ser Glu Leu Glu Gly 
625                 630                 635                 640 


Ile Leu Trp Pro Thr Phe Ala His Val Leu His Glu Asn Val Val Glu 
                645                 650                 655     


Tyr Val Pro Tyr Val Leu Gln Val Leu Ala Gln Leu Val Arg Thr Tyr 
            660                 665                 670         


Gln Ala Ser Asp Ala Ala Gln Arg Trp Ala Glu Thr Pro Ala Glu Asn 
        675                 680                 685             


Tyr Gln Ala Leu Val Cys Pro Leu Thr Gln Pro Gln Met Tyr Glu Ile 
    690                 695                 700                 


Arg Ala His Ile Pro Ala Pro Val Cys Leu Leu Cys Ala Phe Val Glu 
705                 710                 715                 720 


Val Tyr Pro Gly Tyr Val His Arg Ala Gly Met Thr Asn Pro Ala Leu 
                725                 730                 735     


Asn Val Phe Asn Ile Leu Val Arg Leu Lys Asn Tyr Asp Asn Glu Gly 
            740                 745                 750         


Leu Asn Ile Leu Thr Ser Met Leu Leu Ala Tyr Pro Ala Asp Val Met 
        755                 760                 765             


Asp Val Tyr Met Asp Thr Val Leu Lys Val Leu Met Asp Arg Leu Gly 
    770                 775                 780                 


Ser Ser Ser Thr Pro Lys Tyr Val Arg Ile Leu Ile Leu Phe Leu Ser 
785                 790                 795                 800 


Val Val Val Val Gln Arg Gln Asp Ala Asp Tyr Leu Val Thr Arg Leu 
                805                 810                 815     


Asn Asn Ile Glu Ser Gly Leu Phe Met Arg Val Leu Gly Asn Thr Trp 
            820                 825                 830         


Leu Pro Arg Met Gln Lys Ile Thr Gly Asp Val Glu Arg Lys Ala Cys 
        835                 840                 845             


Val Val Ala Leu Ala Arg Leu Leu Cys Glu Ser Thr Thr Leu Gln Ser 
    850                 855                 860                 


Asp Thr Thr Ala Trp Val Thr Ser Ala Ser Ser Cys Leu Arg Met Leu 
865                 870                 875                 880 


His Gly Asp Val Glu Pro Asp Asp His Ile Ser Phe Thr Pro Ala Ala 
                885                 890                 895     


Gly Val Val Gln Asn Ala Gly Ser Leu Cys Gly Tyr Ala Ala Gly Pro 
            900                 905                 910         


Glu Glu Leu Thr Ser Ser Phe His Pro Leu Arg Glu Ala Met Gln Lys 
        915                 920                 925             


Pro Arg Asp Val Cys Ser Gln Val Ala Asp Ala Glu Val Phe Phe Gln 
    930                 935                 940                 


Ile Glu Leu Ser Ser Phe Leu Lys Gly Arg Gly Thr His Leu Ser Ala 
945                 950                 955                 960 


Pro Leu Lys Gln Trp Leu Gly Pro His Thr Pro Ala Trp Leu Gln 
                965                 970                 975 


<210>  2
<211>  239
<212>  PRT
<213>  Leishmania infantum

<400>  2

Met Ser Leu Lys Asp Val Ser Lys Lys Ala Ala Glu Leu Glu Ser Lys 
1               5                   10                  15      


Leu Gly Gly Lys Leu Phe Leu Gly Gly Ala Lys Pro Thr Ala Glu Asp 
            20                  25                  30          


Val Lys Val Phe Asn Asp Leu Leu Gly Ala Asn His Val Asn Leu Tyr 
        35                  40                  45              


Arg Trp Ala Lys Asn Met Ala Thr Tyr Thr Glu Gly Glu Arg Lys Ala 
    50                  55                  60                  


Trp Gly Gly Pro Val Arg Val Ala Ala Pro Glu Leu Arg Met Pro Ala 
65                  70                  75                  80  


Pro Ala Ala Ala Lys Ala Val Arg Ser Asp Ala Ala Ala Glu Lys Arg 
                85                  90                  95      


Ala Ala Pro Lys Ala Ala Ala Val Ala Pro Pro Ser Ala Ala Ala Ala 
            100                 105                 110         


Glu Glu Asp Asp Asp Asp Ile Asp Leu Phe Gly Glu Thr Thr Glu Glu 
        115                 120                 125             


Glu Lys Ala Ala Leu Glu Ala Lys Lys Ala Lys Asp Ala Glu Lys Lys 
    130                 135                 140                 


Lys Ala Lys Lys Asp Val Ile Ala Lys Ser Ser Ile Leu Phe Asp Ile 
145                 150                 155                 160 


Lys Ala Trp Asp Asp Thr Ile Asp Leu Glu Ala Leu Ala Gln Lys Leu 
                165                 170                 175     


His Ala Ile Gln Arg Asp Gly Leu Ile Trp Gly Asp His Lys Leu Val 
            180                 185                 190         


Pro Val Ala Phe Gly Val Lys Lys Leu Gln Gln Leu Ile Val Ile Glu 
        195                 200                 205             


Asp Asp Lys Val Ser Gly Asp Asp Leu Glu Glu Met Ile Met Gly Phe 
    210                 215                 220                 


Glu Glu Glu Val Gln Ser Met Asp Ile Val Ala Trp Asn Lys Ile 
225                 230                 235                 


<210>  3
<211>  845
<212>  PRT
<213>  Leishmania infantum

<400>  3

Met Val Asn Phe Thr Val Asp Gln Val Arg Glu Leu Met Asp Tyr Pro 
1               5                   10                  15      


Asp Gln Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys 
            20                  25                  30          


Ser Thr Leu Ser Asp Ser Leu Val Gly Ala Ala Gly Ile Ile Lys Met 
        35                  40                  45              


Glu Glu Ala Gly Asp Lys Arg Ile Met Asp Thr Arg Ala Asp Glu Ile 
    50                  55                  60                  


Ala Arg Gly Ile Thr Ile Lys Ser Thr Ala Ile Ser Met His Tyr His 
65                  70                  75                  80  


Val Pro Lys Glu Met Ile Gly Asp Leu Asp Asp Asp Lys Arg Asp Phe 
                85                  90                  95      


Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser Ser Glu 
            100                 105                 110         


Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val Val Asp 
        115                 120                 125             


Cys Val Glu Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg Gln Ala 
    130                 135                 140                 


Leu Thr Glu Arg Ile Arg Pro Val Val Phe Ile Asn Lys Val Asp Arg 
145                 150                 155                 160 


Ala Ile Leu Glu Leu Gln Leu Asp Pro Glu Glu Ala Tyr Gln Gly Phe 
                165                 170                 175     


Val Lys Thr Leu Gln Asn Val Asn Val Val Val Ala Thr Tyr Asn Asp 
            180                 185                 190         


Pro Ser Met Gly Asp Val Gln Val Ser Pro Glu Lys Gly Thr Val Ala 
        195                 200                 205             


Ile Gly Ser Gly Leu Gln Ala Trp Ala Phe Ser Leu Thr Arg Phe Ala 
    210                 215                 220                 


Asn Met Tyr Ala Ala Lys Phe Gly Val Asp Glu Leu Lys Met Arg Glu 
225                 230                 235                 240 


Arg Leu Trp Gly Asp Asn Phe Phe Asp Ala Lys Asn Lys Lys Trp Ile 
                245                 250                 255     


Lys Gln Glu Thr Asn Ala Asp Gly Glu Arg Val Arg Arg Ala Phe Cys 
            260                 265                 270         


Gln Phe Cys Leu Asp Pro Ile Tyr Gln Ile Phe Asp Ala Val Met Asn 
        275                 280                 285             


Glu Lys Lys Asp Lys Val Asp Lys Met Leu Lys Ser Leu His Val Thr 
    290                 295                 300                 


Leu Thr Ala Glu Glu Arg Glu Gln Val Pro Lys Lys Leu Leu Lys Thr 
305                 310                 315                 320 


Val Met Met Lys Phe Leu Pro Ala Ala Glu Thr Leu Leu Gln Met Ile 
                325                 330                 335     


Val Ala His Leu Pro Ser Pro Lys Lys Ala Gln Ala Tyr Arg Ala Glu 
            340                 345                 350         


Met Leu Tyr Ser Gly Glu Ala Ser Pro Glu Asp Lys Tyr Phe Met Gly 
        355                 360                 365             


Ile Lys Asn Cys Asp Pro Ala Ala Pro Leu Met Leu Tyr Ile Ser Lys 
    370                 375                 380                 


Met Val Pro Thr Ala Asp Arg Gly Arg Phe Phe Ala Phe Gly Arg Ile 
385                 390                 395                 400 


Phe Ser Gly Lys Val Arg Ser Gly Gln Lys Val Arg Ile Met Gly Asn 
                405                 410                 415     


Asn Tyr Val Tyr Gly Lys Lys Gln Asp Leu Tyr Glu Asp Lys Pro Val 
            420                 425                 430         


Gln Arg Ser Val Leu Met Met Gly Arg Tyr Gln Glu Ala Val Glu Asp 
        435                 440                 445             


Met Pro Cys Gly Asn Val Val Gly Leu Val Gly Val Asp Lys Tyr Ile 
    450                 455                 460                 


Val Lys Ser Ala Thr Ile Thr Asp Asp Gly Glu Ser Pro His Pro Leu 
465                 470                 475                 480 


Arg Asp Met Lys Tyr Ser Val Ser Pro Val Val Arg Val Ala Val Glu 
                485                 490                 495     


Ala Lys Asn Pro Ser Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg 
            500                 505                 510         


Leu Ala Lys Ser Asp Pro Leu Val Val Cys Ser Ile Glu Glu Ser Gly 
        515                 520                 525             


Glu His Ile Val Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu 
    530                 535                 540                 


Lys Asp Leu Gln Glu Asp Phe Met Asn Gly Ala Pro Leu Lys Ile Ser 
545                 550                 555                 560 


Glu Pro Val Val Ser Phe Arg Glu Thr Val Thr Asp Val Ser Ser Gln 
                565                 570                 575     


Gln Cys Leu Ser Lys Ser Ala Asn Lys His Asn Arg Leu Phe Cys Arg 
            580                 585                 590         


Gly Ala Pro Leu Thr Glu Glu Leu Ala Leu Ala Met Glu Glu Gly Thr 
        595                 600                 605             


Ala Gly Pro Glu Ala Asp Pro Lys Val Arg Ala Arg Phe Leu Ala Asp 
    610                 615                 620                 


Asn Tyr Glu Trp Asp Val Gln Glu Ala Arg Lys Ile Trp Cys Tyr Gly 
625                 630                 635                 640 


Pro Asp Asn Arg Gly Pro Asn Val Val Val Asp Val Thr Lys Gly Val 
                645                 650                 655     


Gln Asn Met Ala Glu Met Lys Asp Ser Phe Val Ala Ala Trp Gln Trp 
            660                 665                 670         


Ala Thr Arg Glu Gly Val Leu Cys Asp Glu Asn Met Arg Gly Val Arg 
        675                 680                 685             


Val Asn Val Glu Asp Val Thr Met His Ala Asp Ala Ile His Arg Gly 
    690                 695                 700                 


Gly Gly Gln Ile Ile Pro Thr Ala Arg Arg Val Phe Tyr Ala Cys Cys 
705                 710                 715                 720 


Leu Thr Ala Ser Pro Arg Leu Met Glu Pro Met Phe Val Val Asp Ile 
                725                 730                 735     


Gln Thr Val Glu His Ala Met Gly Gly Ile Tyr Gly Val Leu Thr Arg 
            740                 745                 750         


Arg Arg Gly Val Ile Ile Gly Glu Glu Asn Arg Pro Gly Thr Pro Ile 
        755                 760                 765             


Tyr Asn Val Arg Ala Tyr Leu Pro Val Ala Glu Ser Phe Gly Phe Thr 
    770                 775                 780                 


Ala Asp Leu Arg Ala Gly Thr Gly Gly Gln Ala Phe Pro Gln Cys Val 
785                 790                 795                 800 


Phe Asp His Trp Gln Glu Tyr Pro Gly Asp Pro Leu Glu Pro Lys Ser 
                805                 810                 815     


Leu Ala Asn Thr Thr Thr Leu Gly Ile Arg Thr Arg Lys Gly Leu Lys 
            820                 825                 830         


Pro Asp Ile Pro Gly Leu Asp Gln Phe Met Asp Lys Leu 
        835                 840                 845 


<210>  4
<211>  259
<212>  PRT
<213>  Leishmania infantum

<400>  4

Met Ser Lys His Ser Phe Thr Pro Pro Ser Asn Trp Ala Gln Leu Phe 
1               5                   10                  15      


Ala Arg Leu Glu Asp Tyr Arg Lys His Leu Leu Ala Pro Val Asp Thr 
            20                  25                  30          


Met Gly Cys His Arg Leu His Asp Glu Asn Ala Pro Lys Glu Val Gln 
        35                  40                  45              


Arg Phe Gln Thr Leu Val Ala Leu Met Leu Ser Ala Gln Thr Lys Asp 
    50                  55                  60                  


Ile Val Thr Ala Thr Ala Met Asp Ala Leu Ile Lys Arg Gly Leu Thr 
65                  70                  75                  80  


Ala Gln Ser Ile His Ala Met Thr Thr Thr Glu Leu Asp Met His Ile 
                85                  90                  95      


Cys Lys Val Gly Phe His Asn Thr Lys Val Lys His Ile Lys Glu Val 
            100                 105                 110         


Ala Ala Ile Leu Ile Lys Asp Tyr Gly Gly Lys Val Pro Arg Glu Tyr 
        115                 120                 125             


Glu Glu Leu Ile Ala Leu Pro Gly Val Gly Pro Lys Met Ala Asn Leu 
    130                 135                 140                 


Phe Phe Gln Asp Ala Asp His Arg Thr Val Gly Ile Gly Val Asp Thr 
145                 150                 155                 160 


His Val His Arg Ile Ser Gln Arg Tyr Arg Trp Val Pro Ser Thr Val 
                165                 170                 175     


Lys Thr Pro Glu Asp Thr Arg Lys Ala Leu Glu Ser Trp Leu Pro Gln 
            180                 185                 190         


Lys His Trp Gly Thr Ile Asn Ser Leu Met Val Gly Leu Gly Gln Thr 
        195                 200                 205             


Val Cys Thr Pro Leu Tyr Pro Lys Cys Gly Ile Cys Glu Leu Ser Asp 
    210                 215                 220                 


Ile Cys Pro Asn Ala Phe Lys Glu Val Gln Gln Lys Gly Leu Arg Thr 
225                 230                 235                 240 


Lys Ala Pro Thr Glu Arg Arg Gln Glu Pro Val Pro Gln Lys Lys Arg 
                245                 250                 255     


Arg Ile Lys 
            


<210>  5
<211>  216
<212>  PRT
<213>  Leishmania infantum

<400>  5

Met Gln Gln Ala Pro Ser Asp Cys Val Ala Ser Phe Lys Leu Ile Leu 
1               5                   10                  15      


Val Gly Asp Gly Gly Thr Gly Lys Thr Thr Phe Val Lys Arg His Leu 
            20                  25                  30          


Thr Gly Glu Phe Glu Lys Arg Tyr Val Ala Thr Val Gly Val Asp Val 
        35                  40                  45              


His Pro Leu Thr Phe His Thr Asn Arg Gly Lys Ile Cys Phe Asn Cys 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Lys Phe Gly Gly Leu Arg Asp Gly Tyr 
65                  70                  75                  80  


Tyr Val Glu Gly Gln Cys Ala Ile Ile Met Phe Asp Val Thr Ser Arg 
                85                  90                  95      


Asn Thr Tyr Lys Asn Val Pro Asn Trp Tyr Arg Asp Ile Thr Arg Val 
            100                 105                 110         


Cys Asp Asn Ile Pro Ile Val Leu Val Gly Asn Lys Val Asp Cys Ala 
        115                 120                 125             


Asp Arg Gln Val Lys Ala Lys Met Ile Thr Phe His Arg Lys Lys Gly 
    130                 135                 140                 


Leu Gln Tyr Tyr Asp Ile Ser Ala Lys Ser Asn Tyr Asn Phe Glu Lys 
145                 150                 155                 160 


Pro Phe Val Trp Leu Ala Lys Lys Leu Ala Asn Asp Pro Glu Leu Met 
                165                 170                 175     


Leu Val Glu Val Pro Met Leu Asp Thr Asp Val Val Ala Leu Thr Ala 
            180                 185                 190         


Glu Gln Val Ala Ala Leu Glu Ala Glu Gln Gln Ala Met Ala Asn Ala 
        195                 200                 205             


Pro Leu Pro Met Gly Asp Asp Glu 
    210                 215     


<210>  6
<211>  483
<212>  PRT
<213>  Leishmania infantum

<400>  6

Leu Gln Asp Leu Arg Gln Asn Arg Asn Lys Thr Arg Val Val Ser Phe 
1               5                   10                  15      


Thr Gln Leu Ile Asp Asn Ser Ile Ala Lys Met Glu Lys Val Glu Glu 
            20                  25                  30          


Glu Leu Arg Arg Ser Gln Leu Asp Ala Thr Gln Leu Ala Gln Val Pro 
        35                  40                  45              


Thr Arg Thr Val Lys Met Met Glu Asp Ile Met Asn Ala Thr Gln Ile 
    50                  55                  60                  


Gln Asn Ala Leu Ala Ser Thr Asp Asp Gln Met Gln Thr Gln Leu Ala 
65                  70                  75                  80  


Gln Leu Glu Lys Thr Asn Glu Ile Gln Asn Val Ala Met His Asp Gly 
                85                  90                  95      


Glu Met Gln Ile Ala Glu Glu Gln Met Trp Thr Lys Val Gln Leu Gln 
            100                 105                 110         


Glu Arg Leu Ile Glu Leu Leu Lys Asp Lys Phe Gly Leu Ile Gly Lys 
        115                 120                 125             


Cys Glu Glu Glu Asn Ala Gln Phe Lys Glu Ile Tyr Glu Val Gln Lys 
    130                 135                 140                 


Gln Ala Asn His Glu Thr Ser Gln Met Lys Asp Ala Lys Arg Arg Leu 
145                 150                 155                 160 


Arg Gln Arg Cys Glu Thr Asp Leu Lys His Ile Gln Asp Ala Ile Gln 
                165                 170                 175     


Lys Ala Asp Leu Glu Asp Ala Glu Ala Val Lys Arg Tyr Ala Gly Asn 
            180                 185                 190         


Lys Glu Arg Ser Glu Arg Ala Val Lys Glu Asn Glu Glu Met Gln Glu 
        195                 200                 205             


Glu Ala Trp Asn Lys Ile Gln Asp Leu Glu Arg Gln Leu Gln Asn Leu 
    210                 215                 220                 


Gly Thr Asp Arg Phe Asp Glu Val Lys Arg Arg Ile Glu Glu Val Asp 
225                 230                 235                 240 


Arg Glu Glu Lys Arg Arg Val Glu Asn Ala Gln Phe Leu Glu Val Ala 
                245                 250                 255     


Ala Gln His Lys Lys Leu Leu Glu Leu Thr Val Tyr Asn Cys Asp Leu 
            260                 265                 270         


Ala Met Arg Cys Thr Gly Leu Val Glu Glu Leu Val Ser Glu Gly Cys 
        275                 280                 285             


Ala Gly Val Lys Ala Arg Tyr Asp Lys Thr Asn Gln Asp Leu Ala Ala 
    290                 295                 300                 


Leu Arg Leu Glu Val His Lys Glu His Leu Glu Tyr Phe Arg Met Leu 
305                 310                 315                 320 


Tyr Leu Thr Leu Gly Ser Leu Ile Tyr Lys Lys Glu Lys Arg Leu Glu 
                325                 330                 335     


Glu Val Asp Arg Asn Ile Arg Leu Ala His Ile Gln Leu Glu Phe Cys 
            340                 345                 350         


Val Glu Thr Phe Asp Pro Asn Ala Lys Lys His Ala Asp Met Lys Lys 
        355                 360                 365             


Glu Leu Tyr Lys Met Arg Gln Gly Val Glu Glu Glu Leu Ala Met Leu 
    370                 375                 380                 


Lys Glu Lys Gln Ala Ala Ala Leu Asp Asp Phe Lys Glu Ser Glu Glu 
385                 390                 395                 400 


Ala Leu Asp Ala Ala Gly Ile Glu Phe Ser His Pro Val Asp Glu Asn 
                405                 410                 415     


Asn Glu Glu Val Leu Thr Arg Arg Ser Lys Met Val Glu Tyr Lys Ser 
            420                 425                 430         


His Leu Thr Lys Gln Glu Glu Val Arg Ile Ala Ala Glu Arg Glu Glu 
        435                 440                 445             


Ile Lys Arg Ala Arg Leu Leu Arg Ser Gly Gly Ala Ser Ala Ala Ala 
    450                 455                 460                 


Gln Ile Thr Ser Gly Ser Met Asn Ala Asp Tyr Ala Ala Ser Thr Gln 
465                 470                 475                 480 


Gln Glu Val 
            


<210>  7
<211>  591
<212>  PRT
<213>  Leishmania infantum

<400>  7

Met Met Ala Pro Glu Asp Ala Thr Gly Leu Glu Ala Ala Arg Lys Gln 
1               5                   10                  15      


Lys Ile His Asn Leu Lys Leu Lys Thr Ala Cys Leu Glu Asn Glu Glu 
            20                  25                  30          


Leu Val Gln Glu Leu His Ile Ser Asp Trp Ser Glu Thr Gln Arg Gln 
        35                  40                  45              


Lys Leu Arg Gly Ala His Glu Lys Gly Glu Glu Leu Leu Ala Ser Val 
    50                  55                  60                  


Glu Val Gly Thr Lys Trp Asn Leu Met Glu Ala Tyr Asp Leu Ala Lys 
65                  70                  75                  80  


Leu Met Arg Val Cys Gly Leu Glu Met Ser Gln Arg Glu Leu Tyr Arg 
                85                  90                  95      


Pro Glu Asp Lys Pro Gln Phe Met Asp Ile Ile Gly Val Lys Lys Val 
            100                 105                 110         


Leu Gln Asp Leu Arg Gln Asn Arg Asn Lys Thr Arg Val Val Ser Phe 
        115                 120                 125             


Thr Gln Leu Ile Asp Asn Ser Ile Ala Lys Met Glu Lys Val Glu Glu 
    130                 135                 140                 


Glu Leu Arg Arg Ser Gln Leu Asp Ala Thr Gln Leu Ala Gln Val Pro 
145                 150                 155                 160 


Thr Arg Thr Val Lys Met Met Glu Asp Ile Met Asn Ala Thr Gln Ile 
                165                 170                 175     


Gln Asn Ala Leu Ala Ser Thr Asp Asp Gln Met Gln Thr Gln Leu Ala 
            180                 185                 190         


Gln Leu Glu Lys Thr Asn Glu Ile Gln Asn Val Ala Met His Asp Gly 
        195                 200                 205             


Glu Met Gln Val Ala Glu Glu Gln Met Trp Thr Lys Val Gln Leu Gln 
    210                 215                 220                 


Glu Arg Leu Ile Glu Leu Leu Lys Asp Lys Phe Gly Leu Ile Gly Lys 
225                 230                 235                 240 


Cys Glu Glu Glu Asn Ala Gln Phe Lys Glu Ile Tyr Glu Val Gln Lys 
                245                 250                 255     


Gln Ala Asn Gln Glu Thr Ser Gln Met Lys Asp Ala Lys Arg Arg Leu 
            260                 265                 270         


Arg Gln Arg Cys Glu Thr Asp Leu Lys His Ile Gln Asp Ala Ile Gln 
        275                 280                 285             


Lys Ala Asp Leu Glu Asp Ala Glu Ala Val Lys Arg Tyr Ala Gly Asn 
    290                 295                 300                 


Lys Glu Arg Ser Glu Arg Ala Ile Lys Glu Asn Glu Glu Met Gln Glu 
305                 310                 315                 320 


Glu Ala Trp Asn Lys Ile Gln Asp Leu Glu Arg Gln Leu Gln Asn Leu 
                325                 330                 335     


Gly Thr Asp Arg Phe Asp Glu Val Lys Arg Arg Ile Glu Glu Val Asp 
            340                 345                 350         


Arg Glu Glu Lys Arg Arg Val Glu Asn Ala Gln Phe Leu Glu Ile Ala 
        355                 360                 365             


Ala Gln His Lys Lys Leu Leu Glu Leu Thr Val Tyr Asn Cys Asp Leu 
    370                 375                 380                 


Ala Met Arg Cys Thr Gly Leu Val Glu Glu Leu Val Ser Glu Gly Cys 
385                 390                 395                 400 


Ala Gly Val Lys Ala Arg Tyr Asp Lys Thr Asn Gln Asp Leu Ala Ala 
                405                 410                 415     


Leu Arg Leu Glu Val His Lys Glu His Leu Glu Tyr Phe Arg Met Leu 
            420                 425                 430         


Tyr Leu Thr Leu Gly Ser Leu Ile Tyr Lys Lys Glu Lys Arg Leu Glu 
        435                 440                 445             


Glu Ile Asp Arg Asn Ile Arg Leu Ala His Ile Gln Leu Glu Phe Cys 
    450                 455                 460                 


Val Glu Thr Phe Asp Pro Asn Ala Lys Lys His Ala Asp Met Lys Lys 
465                 470                 475                 480 


Glu Leu Tyr Arg Leu Arg Gln Gly Val Glu Glu Glu Leu Ala Met Leu 
                485                 490                 495     


Lys Glu Lys Gln Ala Ala Ala Leu Asp Asp Phe Lys Glu Ser Glu Glu 
            500                 505                 510         


Ala Leu Asp Ala Ala Gly Ile Glu Phe Ser His Pro Val Asp Glu Asn 
        515                 520                 525             


Asn Glu Glu Val Leu Thr Arg Arg Ser Lys Met Val Glu Tyr Lys Ser 
    530                 535                 540                 


His Leu Thr Lys Gln Glu Glu Val Arg Ile Ala Ala Glu Arg Glu Glu 
545                 550                 555                 560 


Ile Lys Arg Ala Arg Leu Leu Arg Ser Gly Gly Glu Ser Ala Ala Ala 
                565                 570                 575     


Gln Ile Thr Ser Gly Ser Met Asn Ala Asp Tyr Ala Ala Ser Ala 
            580                 585                 590     


<210>  8
<211>  700
<212>  PRT
<213>  Leishmania infantum

<400>  8

Met Thr Ser Thr Thr Val Thr Asp Lys Asp Phe Leu Ala Lys Lys Ile 
1               5                   10                  15      


Val Ser Ala Asp Gly Pro Lys Gly Gly Glu Val Val His Glu Leu Ser 
            20                  25                  30          


Leu Ser Glu Trp Cys Ile Thr Arg Ile Glu Pro Glu Glu Glu Ser Asn 
        35                  40                  45              


Arg Arg Arg Ser Val Leu Glu Arg Ile Val Asn Val Val Arg Val Trp 
    50                  55                  60                  


Ile Arg His Thr Met Ile Thr Glu Phe Arg Met Pro Glu Ala Ala Ala 
65                  70                  75                  80  


Ala Gln Val Glu Gly Arg Ile Phe Ala Thr Gly Ser Tyr Arg Tyr Asn 
                85                  90                  95      


Val His Thr Ser Gly Ser Asp Ile Asp Met Val Leu Ile Ala Pro Ser 
            100                 105                 110         


Arg Ile Thr Arg Glu His Phe Phe Asn Thr Leu Ala Pro Arg Leu Lys 
        115                 120                 125             


Ser Glu Pro Trp Val Thr Asp Leu His Cys Ile Arg Glu Ser Arg Val 
    130                 135                 140                 


Pro Ile Ile Ala Met Val Cys Asp Gly Ile Asp Ile Asp Leu Ser Phe 
145                 150                 155                 160 


Gly Ser Ile Arg Gln Asp Arg Val Pro Glu Val Ile Thr Asp Asp Leu 
                165                 170                 175     


Leu Gln Gly Leu Asp Glu Gln Ser Val Leu Ser Cys Asn Ala Val Arg 
            180                 185                 190         


Val Ala His Asn Ile Met Asp Leu Val Pro Asn Lys Ala Val Phe Arg 
        195                 200                 205             


Gln Thr Leu Arg Phe Val Lys Ala Trp Gly Lys Ala Arg Ser Ile Tyr 
    210                 215                 220                 


Ser Asn Thr Phe Gly Phe Pro Ser Gly Ile Gly Trp Ala Ile Leu Thr 
225                 230                 235                 240 


Ala Phe Val Cys Gln Cys Tyr Pro Asn Gln Asn Ala Ala Gly Met Val 
                245                 250                 255     


Thr Arg Phe Phe Arg Thr Tyr His Thr Trp Phe Lys Pro Asn Pro His 
            260                 265                 270         


Glu Thr Gly Thr Glu Asn Arg Ala Ile Tyr Leu Thr Glu Ser Met Arg 
        275                 280                 285             


Ala Arg Thr His Leu Gly Arg Gly Trp Asp Pro Arg Glu Ser Lys Ser 
    290                 295                 300                 


Asp Ala Met Ala Leu Phe Pro Val Leu Thr Pro Ala Val Pro Tyr Gly 
305                 310                 315                 320 


Asn Thr Cys Tyr Asn Val Thr Leu Thr Asn Leu Arg Gln Leu Cys Asp 
                325                 330                 335     


Glu Phe Gln Arg Gly His Asp Leu Leu Ser Lys Asp Leu Gly Met Ser 
            340                 345                 350         


Ala Ala Glu Ala Lys Ala Lys Phe Gly Pro Phe Gly Val Trp Ser Arg 
        355                 360                 365             


Val Leu Glu Pro Ala Pro Phe Phe Gly Lys Phe Gln His Tyr Leu Gln 
    370                 375                 380                 


Ile Lys Val Ser Cys Ser Asp Ala Glu His Tyr Gln Ala Tyr Ala Asp 
385                 390                 395                 400 


Gly Val Glu Ser Arg Ile Arg Ile Leu Trp Ala Gly Asn Ala Ser Ser 
                405                 410                 415     


Arg Gly His Thr Leu Glu Asp Tyr Arg Gln Leu Arg Leu His Leu Asn 
            420                 425                 430         


Pro Arg Arg Phe Glu Asp Pro Glu Glu Val Gln Leu Arg Thr Arg Leu 
        435                 440                 445             


Thr Ser Lys Ala Thr Gly Ala Ala Ala Ala Ala Ser His Thr Arg Gly 
    450                 455                 460                 


Ser Val Gly Ser Arg Ala Ser Gly Gln Leu Gly Asp Gly Gly Ser Ser 
465                 470                 475                 480 


Leu His Gly Asn Leu Asn Val Lys Asp Ser Ser Ala Pro Ser Gly Pro 
                485                 490                 495     


Thr Trp Phe Thr Ala His Tyr Phe Ile Gly Met Thr Val Asp Thr Lys 
            500                 505                 510         


Val Ser Ser Ala Lys Ile Asp Leu Ala Pro Ala Ile Arg Thr Phe His 
        515                 520                 525             


Thr Val Val Arg Glu Leu Arg Gln Tyr Arg Glu Gly Val Thr Arg Leu 
    530                 535                 540                 


Pro Ala Ile Thr Val Val Asp Met Ala Arg Ile Pro Thr Phe Val Lys 
545                 550                 555                 560 


Glu Ala Ala Gly Tyr Ile Glu Glu Thr Ala Ala Ala Gln Glu Glu Arg 
                565                 570                 575     


Ser Ser Ser Glu Ala Glu Glu Ala Arg Asn Asn Ser Ser Thr Ala Ala 
            580                 585                 590         


Arg Ala Asp Ala Ala Lys Arg Asp Gly Thr Ser Ala Ala Ser Thr Thr 
        595                 600                 605             


Thr Ser Lys Pro Ser Thr Ala Ala Ser Ala Ala Asp Gly Ser Ala Ser 
    610                 615                 620                 


Glu Thr Ser Arg Gly Leu His Asp Gly Gly Ala Gly Asn Gly Ala Ala 
625                 630                 635                 640 


Ser Ser Ile Asp Ser Tyr Ala Arg Lys Arg Thr Arg Asp Gln Tyr Gly 
                645                 650                 655     


Thr Asp Gly His Gly Thr Val Ala Ala Lys Ala Glu Thr Ser Thr Ala 
            660                 665                 670         


Ala Gly Ser Gly Ser Gly Ala Ala Gly Arg Ala Gln Ala Glu Glu Asp 
        675                 680                 685             


Ala Asp Asp Ile Glu Gln Ala Leu Gly Leu Asp Phe 
    690                 695                 700 


<210>  9
<211>  121
<212>  PRT
<213>  Leishmania infantum

<400>  9

Met Ser Ala Glu Asn Gly Gly Asn Ala Ile Val Arg Val Ser Ser Asn 
1               5                   10                  15      


Lys Arg Lys Phe Gly Tyr Val Asp Tyr Thr Lys His Arg Leu His Glu 
            20                  25                  30          


Gly Tyr Pro Glu Val Val Ile Ser Ala Leu Gly Thr Ala Ile Ala Asp 
        35                  40                  45              


Ala Val Ser Val Val Glu Leu Leu Lys Asn Gln Gly Val Val Glu Val 
    50                  55                  60                  


Lys Lys Ile Cys Thr Ser Arg Ala Gln Phe Asp Asp Val Arg Ser Thr 
65                  70                  75                  80  


Thr Thr Asp Lys Ile Glu Val Val Val Val Lys Ser Pro Asp Phe Asp 
                85                  90                  95      


Ala Ile Tyr Asp Gln Gln Gln Lys Asp Arg Glu Ile Ala Lys Ala Arg 
            100                 105                 110         


Ala Glu Ala Asp Glu Ala Asp Asp Glu 
        115                 120     


<210>  10
<211>  484
<212>  PRT
<213>  Leishmania infantum

<400>  10

Met Asp Arg Phe Gly Ala Gly Ala Ala Leu Val Ser Val Gly Ser Ser 
1               5                   10                  15      


Thr Gly Ala Thr Cys Pro Ala Glu Ala Lys Ser Leu Lys Ala Ala Ala 
            20                  25                  30          


Asp Gly Asp Thr Thr Gly Ser Ser Pro Asp Ser Arg Pro Ala Ala Gly 
        35                  40                  45              


Glu Pro His Pro Gly Gly Glu Asp Glu Ala Ser Leu Ala Asp Thr Cys 
    50                  55                  60                  


Gly Ser Val Gly Lys Glu Ala Asp Asp Asn Ala Val Thr Gly Asp Asn 
65                  70                  75                  80  


Gly Gly Asp Thr Glu Ala Asp Ala Ala Gly Ala Glu Glu Glu Glu Leu 
                85                  90                  95      


Ser Pro Glu Glu Asp Gly Gly Gln Gly Asp Glu Asp Ala Glu Asp Val 
            100                 105                 110         


Val Glu Asp Val Gly Tyr Ala Glu Glu Glu His Ala Asp Glu Glu Glu 
        115                 120                 125             


Tyr Glu Tyr Glu Pro Glu Asp Ala Val Ala Asp Pro Ser Ala Thr Ala 
    130                 135                 140                 


Ser Ser Ser Ser Lys Pro Leu Met Ile Thr Ile Gly Thr Arg Gln Tyr 
145                 150                 155                 160 


Lys Thr Ser Ala Phe Val Lys Asn Arg Gly Leu Ser Tyr Val Pro Gly 
                165                 170                 175     


Lys Leu Lys Ser Asn Pro Lys Ala Thr Phe Gln Pro Cys Thr Thr Asn 
            180                 185                 190         


Ala Pro His Ser Ile Leu Asp Cys Gln Lys Leu His Leu Ser Asn Arg 
        195                 200                 205             


Gly Val Leu Val Arg Asp Arg Phe Ile Arg Leu Asn Met Leu Val Asp 
    210                 215                 220                 


Asn Pro Gly Lys Gln Ala Leu Leu Arg His Pro Gly Arg Ser Leu Lys 
225                 230                 235                 240 


Met Arg Ile Cys Arg Arg Asp Val Glu Pro Gln Lys Gly Glu Thr His 
                245                 250                 255     


Asn Pro Ala Thr Cys Ser Asp Leu His Leu Leu Pro Asp Ile Val Phe 
            260                 265                 270         


Val Gly Ile Pro Gly Leu Arg Thr Ala Tyr Phe Glu Ala Glu Leu Arg 
        275                 280                 285             


His Asn Leu Ala Phe Gly Lys Leu Lys Glu Glu Ala Trp Glu Thr Gln 
    290                 295                 300                 


Cys Gly Thr Trp Cys Arg Gly Thr Arg Ser His Val Val Thr Thr Cys 
305                 310                 315                 320 


Arg Phe Leu His Tyr Asn Arg Gly Asp Asn Tyr Thr Glu Lys Pro Ile 
                325                 330                 335     


Pro Pro His Arg Pro Leu Ala Ala Ile Pro Asp Leu Thr Pro Ser Arg 
            340                 345                 350         


Pro Ala Gln Ala Thr Asp Ser Asn Lys Arg Ala Arg Gly Arg Gly Arg 
        355                 360                 365             


Gly Asp Arg Gly Gly Arg Gly Arg Glu Asn Cys Arg Gly Arg Gly Arg 
    370                 375                 380                 


Gly Ser Arg Gly Ala Ala Ala Ile Pro Leu Pro Ala Ala Phe Glu Arg 
385                 390                 395                 400 


Gly Tyr Val Ala Pro Ser Gln Asp Ser Ala Pro Gln Ala Ser Ser Ile 
                405                 410                 415     


Thr Thr Arg Ala Ser Gly Ala Glu Asn His Val Lys Ser Pro His Asp 
            420                 425                 430         


Ala Leu Ala Glu Ala Asp Trp Met Thr Asp Asn Gly Asp Glu Gly Ser 
        435                 440                 445             


Pro Ile Asp Tyr Arg Met Leu Ser Val Leu Leu Val Leu Leu Gly Val 
    450                 455                 460                 


Phe Val Phe Leu Leu Ser Val Ala Leu His Arg Lys Ser Asn Pro Ala 
465                 470                 475                 480 


Ser Thr Ala Pro 
                


<210>  11
<211>  807
<212>  PRT
<213>  Leishmania infantum

<400>  11

Met Ser Glu Ile Ser Phe Ser Glu Met Ser Leu His Glu Val Pro Leu 
1               5                   10                  15      


Ala Ser Glu Ala Thr Pro Ser Ser Ala Val Val Leu Gly Gly Arg Thr 
            20                  25                  30          


Asp Leu Arg Val Gly Asp Phe Val Gly Phe Gln Arg Ile Ser Pro Ser 
        35                  40                  45              


Lys Glu Trp Lys Leu Ser Leu Gly Lys Val Ile Ala Leu Pro Thr Ala 
    50                  55                  60                  


Leu Thr Val Lys Val Ala His Phe Asp Ala Val Asn Glu Thr Thr Val 
65                  70                  75                  80  


Thr Gln Asp Pro Ile Ser Glu Gln Met Val Arg Gln Lys Ala Ala Glu 
                85                  90                  95      


Thr Gln Lys Met Asp Ile Trp His Asn Arg Glu Ala Leu Arg Glu Asn 
            100                 105                 110         


Leu Ala Gln Glu Ser Ala Lys Glu Lys Ala Ala Thr Gln Arg Leu Leu 
        115                 120                 125             


Ala Ala Arg Asp Gln Thr Val Thr Arg Gln Met Ala Thr Gly Asp Lys 
    130                 135                 140                 


Val Thr Ala Ser Leu Glu Asn Leu Asp Asn Ala Arg Arg Arg Leu Arg 
145                 150                 155                 160 


Glu Val Pro Val Lys Glu Trp Gly Ala Leu Arg Ser Ser Tyr Leu Pro 
                165                 170                 175     


Ser Ala Glu Ile Leu Gly Val Met Arg Ser Val Met Leu Ile Leu Tyr 
            180                 185                 190         


Glu Asp Ser Val Thr Lys Trp Glu His Ile Gln Glu Val Met His Arg 
        195                 200                 205             


Gln Asp Phe Met Glu Arg Ile Leu Gly Trp Asp Cys Thr Ala Thr Pro 
    210                 215                 220                 


Met Ser Leu Ser Arg Arg Lys Arg Ile Val Ala Leu Cys Ala Gly Lys 
225                 230                 235                 240 


Asp Val Glu Gly Ala Pro Ser Lys Lys Leu His Pro Ser Gly Thr Arg 
                245                 250                 255     


Ser Arg Ser Pro Ser Arg Pro Leu Val Val Ala Ala Lys Ser Thr Asn 
            260                 265                 270         


Pro Ser Asn Val Val Ile Leu Asp Lys Asn Val Arg Thr Trp Ile Asn 
        275                 280                 285             


Ala Gln Leu Ser Cys Ser Glu Ala Ala Arg Glu Gln Glu Met Met Ile 
    290                 295                 300                 


Asn Ser Cys Phe Ala Glu Gln Gln Glu Gln Arg Ala Leu Leu Arg Glu 
305                 310                 315                 320 


Ile Asn Asp Met Arg Val Gly Ile Ser Thr Ile Glu Val Gln Met Leu 
                325                 330                 335     


Glu Met Lys Asn Ala Ile Leu Gly Ile Asp Asp Ala Pro Arg Pro Ile 
            340                 345                 350         


Met Pro Leu Asp Ala Tyr Pro Thr Asp Thr Thr Phe Tyr Lys Arg Thr 
        355                 360                 365             


Tyr Pro Asp Ala Asp Gly Arg Phe Val Gln Glu Ile Ile Leu Arg Glu 
    370                 375                 380                 


Ala Val Ile Leu Asn Phe Gly Pro Ile Ala Glu Glu Asp Ala Glu Gly 
385                 390                 395                 400 


Tyr Val Arg Leu Asn Ser Ala Gln Val Glu Arg Leu Arg Asp Ala Val 
                405                 410                 415     


Val Ser Thr Asn Val Arg His Asp Ala Glu Glu Met Glu Glu Leu Leu 
            420                 425                 430         


Ala Arg Lys Glu Arg Glu Glu Glu Glu Ile Ala Glu Leu Lys Ser Arg 
        435                 440                 445             


Ile Ser Glu Leu Arg Asn Lys Val Ser Leu Thr Ala Glu Glu Glu Glu 
    450                 455                 460                 


Glu Leu Ala Gln Leu Glu Lys Leu Leu Ala Asp Ala Glu Arg Arg His 
465                 470                 475                 480 


His Ala Thr Leu Ser Arg Ile Ala Asp Leu Tyr Ala Cys Gly Arg Gly 
                485                 490                 495     


Ala Arg Glu Ile Thr Leu Ala Ile Lys Arg Pro Glu Phe Arg Tyr Thr 
            500                 505                 510         


Arg Leu His Cys Lys Met Ser Gly Asp Trp Glu Thr Ile Leu Ser Asp 
        515                 520                 525             


Ala Glu Arg Tyr Ser Glu Met Ile Ala Ala Phe Cys Asp Asp Val Ser 
    530                 535                 540                 


Thr Leu Leu Asn Ile Pro Ala Ser Tyr Val Leu Asp Ile Asp Thr Cys 
545                 550                 555                 560 


Cys Gly Ser Leu Leu Ile Asp Phe Thr Val Lys His Ser Gly Asp Leu 
                565                 570                 575     


Asp Asp Glu Gln Leu Gln Asp Leu Val Asn Lys Gly Cys Phe Ser Ala 
            580                 585                 590         


Leu Cys Met Phe Tyr Glu Lys Val Thr Phe Lys Lys Thr Ser Pro Leu 
        595                 600                 605             


Asn Thr Ser Gln Gln Gln Leu Ala Tyr Asp Leu Glu Gln Arg Leu Asn 
    610                 615                 620                 


Gly Pro Ala Pro Ile Ser Gly Met Gly Ile Lys Gln Ile Leu Thr Asp 
625                 630                 635                 640 


Tyr Tyr Asn Ala Asp Gly Thr Leu Asp Glu Glu Phe Ser Asp Glu Val 
                645                 650                 655     


Lys Ala His Lys Asp Tyr Arg Lys Ala Leu Ile Thr Ile Pro Pro Leu 
            660                 665                 670         


Arg Glu Asp Tyr Asp Asp Val Thr Val Arg Gly Pro Phe Glu Gln His 
        675                 680                 685             


Ala Glu Asp Glu Gly Glu Ala Leu Ser Ala Ala Val Pro Val Ser Ile 
    690                 695                 700                 


Met Ala Ser Ser Val Ala Gly Asn Arg Asn Lys Gly Glu Asp Glu Leu 
705                 710                 715                 720 


Ala Gly Ala Thr Gln Thr Ser Ile Asp Leu Thr Asp Thr Gly Ala Ala 
                725                 730                 735     


Thr His Asp Met Thr Glu Ser Ala Pro Ala Met Glu Val His Ser His 
            740                 745                 750         


Asp Met Asn Leu Ser Tyr Asn Pro Gln Pro Ala Val Asp Ala Ala Ala 
        755                 760                 765             


Pro Ala Ala Pro Ala Ala Pro Ser Val Ser Ala Pro Ala Glu Asn Val 
    770                 775                 780                 


Gly Gln Pro Gly Val Pro Asn Thr Asp Ala Gly Ser Leu Ser Arg Ser 
785                 790                 795                 800 


Ser Glu Met Ser Arg Val Asn 
                805         


<210>  12
<211>  2025
<212>  PRT
<213>  Leishmania infantum

<400>  12

Met Ser Ala His Gln Gln Leu Pro His Ser Pro Leu Ala Arg Ala Ser 
1               5                   10                  15      


Glu Gly Ile Ala His Ala Pro Ser Thr Gly His Ser Ser Arg Val Ser 
            20                  25                  30          


Gln Asp Val Arg Gln Ala Arg Ala Gln Gln Ala Phe Asp Ala Gln Ala 
        35                  40                  45              


Ser Glu Leu Glu Gln Gln Leu Asp Gly Gln Leu Gly Leu Val Phe Thr 
    50                  55                  60                  


Leu Met Arg Gln Val Met Val Leu Asp Ala His Val Ala Ala Gly Ser 
65                  70                  75                  80  


Thr Ala Asp Thr Ser Asn Thr Leu Leu Ser Ser Gly Ala Ala Thr Glu 
                85                  90                  95      


Asp His Arg Glu Leu Leu Val Gly Gln Leu Glu Glu Val Glu Asp Ala 
            100                 105                 110         


Ala Val Ser Thr Ala Leu His Phe Val Glu Leu Ala Asn Arg His Ala 
        115                 120                 125             


Leu Glu Trp Met Asn Gln Gly His Tyr Ser Ala Ala Leu Gln Leu Leu 
    130                 135                 140                 


Gln Arg Ala Asp Arg Leu Leu Arg Gln Asn Ala Gly Arg Val Phe Arg 
145                 150                 155                 160 


Tyr Leu Pro Asp Pro Val Glu Leu Glu Ala Pro Ser Ile Asn Gly Ala 
                165                 170                 175     


Val Gly Gly Arg Asn Gly Pro Arg Asp Gly Cys Asp Thr Thr Pro Leu 
            180                 185                 190         


Gln Arg Pro Ala Ala Ala Ser Ala Gln Ala Arg Ser His Asp Arg Lys 
        195                 200                 205             


Ser Pro Ala Ile Phe Thr Ser Ser Asp Ser Gly Ala Ser Ile Asn His 
    210                 215                 220                 


Ile Ser Ser Tyr Asn Val Cys Ser Ile Ser Val Pro Phe Phe Ser Pro 
225                 230                 235                 240 


Ser Gln Glu Pro Arg Arg Leu Lys Ala Val Ala Ala Val Ala His Asn 
                245                 250                 255     


Leu Gly Val Tyr His Phe Lys Leu Gly Glu Tyr Thr Leu Ala Ser Pro 
            260                 265                 270         


Leu Phe Ala Arg Ser Ala Ala Leu Glu Glu Glu Leu Gln Ala Pro Gly 
        275                 280                 285             


Ile Gly Ile Thr Tyr Phe Asn Met Ala Gln Thr Gln His Gly Leu Arg 
    290                 295                 300                 


Gln Leu Thr Glu Ala Leu Arg Tyr Ala Glu Met Ala Glu Glu Ala Val 
305                 310                 315                 320 


Glu Arg Gln Val Phe Gln Ala Lys Asp Lys Ala Thr Gln Met Arg Arg 
                325                 330                 335     


Arg Leu Thr Gln Glu Arg Ala Phe Gln Val Arg Asp Phe Pro Asp Gly 
            340                 345                 350         


Ala His Ala Ala Arg Arg Gly Gly Glu Asp Asn Arg Asp Gly Val Ala 
        355                 360                 365             


Ala Ala Ala Asn Thr Ser Ala Asp Gly His Arg Cys Ser Asp Ala Ala 
    370                 375                 380                 


Ala Thr Thr Glu Gly Glu Glu Glu Lys Ala Leu Met Arg Met Trp Ile 
385                 390                 395                 400 


Gln Trp Arg Glu Ser Val Cys Phe Leu Ser Tyr Val Lys Gln Thr His 
                405                 410                 415     


Ala Gly Trp Leu Asp Glu Met Gly Leu Tyr Lys Glu Ala Tyr Gln His 
            420                 425                 430         


Tyr Gln Gln Ala His Arg Trp Leu Leu Ala Ile Pro Arg Leu Ala Thr 
        435                 440                 445             


Glu Glu Gln Gln Arg Ala Gln Leu Leu Lys Gln Tyr Met Ala Thr Met 
    450                 455                 460                 


Lys Ala Arg Trp Arg Arg Glu Glu Val Glu Val Glu Leu Tyr His His 
465                 470                 475                 480 


Pro Leu Arg Thr Ser Ser Ala Ala Arg Ser Gly Ala Val Pro Ala Ala 
                485                 490                 495     


Ser Tyr Pro Ser His Ser Thr Arg Ala Pro Ser Lys His Arg Val Arg 
            500                 505                 510         


Thr His Gln Arg Pro Gln Arg Ser Pro Ala Val Leu Ser Ala Ala Val 
        515                 520                 525             


Pro Ile Ala Lys Tyr Phe Thr Ser Pro Leu Gln Ser Thr Val Val Thr 
    530                 535                 540                 


Ser Val Leu Pro Arg Asn Val Glu Val Val Gly Arg Arg Pro Arg Gly 
545                 550                 555                 560 


Pro Ser Arg Ala Phe His Arg Glu Ile Phe Pro Thr Pro His Glu Ala 
                565                 570                 575     


Pro Phe Leu Trp Pro Ala Ala Ser Ala Phe Ala Pro Arg Asn Ser Met 
            580                 585                 590         


Gly Ala Gln Pro Arg Arg Arg Pro Ser Ser Ala Asn Val Ala Leu His 
        595                 600                 605             


Ser Ala Tyr Ala Pro Arg Arg Pro Ser Ala Ser Ser Leu Arg His Arg 
    610                 615                 620                 


Pro Thr Ala Thr Asp His Ala Thr Ala Ser Ala Glu Gln Asp His Lys 
625                 630                 635                 640 


Pro Leu Ser His Pro Ser Pro Glu Thr Arg Glu Gln Gln Gln Gln Gln 
                645                 650                 655     


Gln Gln Gln His Gly Gly Lys Arg Ala Ser Trp Asp Pro Ser Met Arg 
            660                 665                 670         


Val Pro Ile Pro Pro Pro Gly Arg Arg Thr Gly Tyr Arg Thr Ser Thr 
        675                 680                 685             


Gly Arg Ala Gly Ser Ala Ala Ser Gly Pro Leu Leu His Arg Gly Ser 
    690                 695                 700                 


Ala Ser Leu Leu Arg Ser Asn Ala Gly Glu Pro Glu Met Phe Thr Thr 
705                 710                 715                 720 


Ala Arg Leu Pro Pro Arg Ala Ser Ser Thr Pro Tyr Asp Ala His Thr 
                725                 730                 735     


Arg Phe Ala Pro Gln Tyr His Pro Ser Pro Pro Arg Glu Pro Ser Pro 
            740                 745                 750         


Val Ser Ser Thr Leu Ala Glu Ser Cys Val Glu Arg Gly Leu Leu Phe 
        755                 760                 765             


Glu Ala Glu Pro Glu Thr Pro Lys Ser Gln Pro His His Arg His Ser 
    770                 775                 780                 


Glu Pro Val Ile Pro Asp Ala Leu Ile Val Glu Ser Val Gln Lys Val 
785                 790                 795                 800 


Ala Ala Asp Pro Pro Gly Gln Arg Ser Glu Ala Ala Ala Thr Pro Gln 
                805                 810                 815     


Lys Gly Ser Ala Gly Ala Gly Val Ser Asp Leu Thr Ala Ser Ala Pro 
            820                 825                 830         


Ser Ala Ala Arg Gln Leu Pro Gly Leu Thr Pro Ser Pro Arg Ile Pro 
        835                 840                 845             


Gly Asp Leu Thr Trp Cys Val Thr Val Leu Gln Ala Phe Leu Arg Pro 
    850                 855                 860                 


Arg Cys Arg His Arg Thr Leu Leu Asp Thr Glu Gly Glu Arg Asp Arg 
865                 870                 875                 880 


Gly Lys Pro Ala Asp Arg Gly Ser Leu Gly Gly Glu Tyr Gly Gly His 
                885                 890                 895     


Val Ala Val Asp Ala Ile Met Lys Arg Arg Lys Ser Val Ile Ser Tyr 
            900                 905                 910         


Glu Ser Asp Asp Gly Asp Ala Ser Gly Gly Ser Ala Ala Arg Ala Pro 
        915                 920                 925             


Thr Gly Thr Arg Ser Pro Asp Arg Phe His Ser Glu Gly Phe His Gly 
    930                 935                 940                 


Ala Gly Asp Ser Ala Asp Ala Ala Ala Leu Thr Ala Thr Cys Glu Tyr 
945                 950                 955                 960 


Val Ala Thr Cys Asp Ser Gly Ala Val Ile Ala Val Ala Leu Thr Pro 
                965                 970                 975     


Phe Pro Ile Ser His Glu Lys Asn Glu Gly Glu Ile Tyr Tyr Leu His 
            980                 985                 990         


Glu Pro Ser Val Asp Asp Asp Glu  Val Met Leu Lys Ala  Glu Pro Leu 
        995                 1000                 1005             


Asp Ser  Gly Arg Arg Gly Arg  Met Pro Val Ser Ala  Asp Ala Leu 
    1010                 1015                 1020             


Leu Gly  Arg Lys Gly Asp Pro  Cys Cys Gly Asn Ala  Ser Ala Asn 
    1025                 1030                 1035             


Thr Ser  Lys Thr Asn Thr His  Asp Thr Ser Gly Lys  Gly Glu Gly 
    1040                 1045                 1050             


Asp Ala  Met Ala Met Leu Ala  Glu Glu Arg Glu Asp  Ala Pro Gly 
    1055                 1060                 1065             


Asn Ala  Leu Val Leu Glu Thr  Arg Ala Ser Val Pro  Glu Glu Ala 
    1070                 1075                 1080             


Lys Ala  Asp Ser Leu Ser Thr  Leu Pro Arg Leu Asn  Ala Gly Asp 
    1085                 1090                 1095             


Arg Lys  Asp Ser Val Val Ala  Ser Leu Ala Met His  Ala His Lys 
    1100                 1105                 1110             


Asp Asp  Gln His Gln Val Cys  Gly Ala Glu Gly Arg  Gly Ala Ala 
    1115                 1120                 1125             


Ala Gln  Arg Thr Ala Ser Pro  Phe Arg Ala Ser Ala  Asp Glu Val 
    1130                 1135                 1140             


Leu Arg  Ala Glu Gln Ala Glu  Leu Ala Cys Ala Ala  Val Ala Val 
    1145                 1150                 1155             


Ala Gly  Ser Leu Ser Ala Arg  Gln Ser Thr Thr Leu  Asn Lys Val 
    1160                 1165                 1170             


Ala Ser  Ser Val Ala Thr Val  Ala Glu Ala Phe Ala  Ser Ala Ala 
    1175                 1180                 1185             


Gly Asp  Tyr Ser Asp Val Pro  Lys Pro Ser Ser Leu  Ser Pro Thr 
    1190                 1195                 1200             


Ser Trp  Ala Ala Cys Arg Gly  Thr Arg Thr Pro Phe  Gln Leu Pro 
    1205                 1210                 1215             


Gln Asn  Pro Glu Ala Arg Glu  Gly Glu Leu Lys Thr  Leu Pro Ala 
    1220                 1225                 1230             


Pro Ala  Gly Leu Leu His Ser  Ser His Ser Pro Val  Pro Gln Ala 
    1235                 1240                 1245             


Pro Gln  Glu Thr Asn Arg Arg  Val Asp Gln Val Asp  Gly Ser Cys 
    1250                 1255                 1260             


Ser Ala  Gly Leu Gly Ala Ala  Gly Glu Ala Glu Ala  Ser Asn Ile 
    1265                 1270                 1275             


Phe Cys  Ala Ala Ala His Ala  Thr Leu Ser Asp Arg  Ser Arg Glu 
    1280                 1285                 1290             


Asp Asp  Val Ser Asp Arg Thr  Ala Ala Arg Lys Ala  Ala Leu Trp 
    1295                 1300                 1305             


Asp Ser  Pro Thr Pro Pro Ser  Ala Phe Ser Ala Cys  Ala Glu Asn 
    1310                 1315                 1320             


Val Cys  Ala Ser Ser Val Glu  Asp Thr Ala Leu Pro  Gly Gly Ser 
    1325                 1330                 1335             


Ser Met  Arg Ala Ser Ile Ser  Ala Thr Ser Ala Arg  Phe Thr Ala 
    1340                 1345                 1350             


Tyr Ala  His Glu Ala Pro Gln  Lys Ile Gly Ser Ser  Ala Ser Ala 
    1355                 1360                 1365             


Cys Thr  Gly Asp Pro Glu Val  Glu Gly Asp Asn Gly  Pro Ala Ser 
    1370                 1375                 1380             


Glu Ala  Leu Gln Gln Glu Met  Glu Glu Gly Gly Val  Ser Val Trp 
    1385                 1390                 1395             


His Lys  Gly Ser Ser Ala Ala  Pro Glu Ala Ser Ala  Ala Ser Ala 
    1400                 1405                 1410             


Gly Arg  Ala Ala Ser Ser Gly  Arg Glu Thr Ala Gly  Cys Gly Glu 
    1415                 1420                 1425             


Ala Val  Pro Trp Thr Glu Lys  Val Ser Asp Ala Thr  Asp Ala Leu 
    1430                 1435                 1440             


Ala Val  Thr Val Ala Leu Pro  Ser Ala Glu Ala Glu  Glu Gln Leu 
    1445                 1450                 1455             


Thr Thr  Pro Asp Asn Asp Gly  His Thr His Lys Gln  Ser Arg Ala 
    1460                 1465                 1470             


Ala Thr  Val Leu Ser Pro Pro  Ser Arg Ile Arg Glu  Ser Cys Arg 
    1475                 1480                 1485             


Gly Glu  Phe Pro Thr Thr Thr  Ser Ala Ala Arg Pro  Pro His Thr 
    1490                 1495                 1500             


Lys Gly  Ala Asp Leu Gln Trp  Pro Glu Asp Leu Ala  Ser Ala Lys 
    1505                 1510                 1515             


Ala Thr  Thr Glu Glu Arg Arg  Ala Glu Val Ser Ala  Ala Ile Lys 
    1520                 1525                 1530             


Glu Gly  Pro Ser Pro Glu Glu  Ala Met Ala Ala Pro  Gln Pro Leu 
    1535                 1540                 1545             


Ala Thr  Leu Pro Pro Arg Arg  Gly Arg Val Phe Val  Phe Ala Pro 
    1550                 1555                 1560             


His Gln  Leu Ala Ala Ser Ala  Ser Met Glu Leu Thr  Ser Ser Asp 
    1565                 1570                 1575             


Leu Ser  Phe Arg Ser Gly Asp  Ala Gly Glu Arg Ile  Arg Ser Pro 
    1580                 1585                 1590             


Thr Arg  Thr Leu Lys Gln Pro  Ala Ala Thr Leu Gly  Thr Glu Thr 
    1595                 1600                 1605             


Val Glu  Asp Gly Ala Ala Lys  Pro Val Leu Leu Arg  Val Ala Gly 
    1610                 1615                 1620             


Gly Gly  Arg Thr Ser Gly Ser  Ser Asp Gly Val Leu  Cys Ser Lys 
    1625                 1630                 1635             


Glu Gly  His Cys Cys Ala Ala  Ala Met Met Ala Cys  Ala Thr Ala 
    1640                 1645                 1650             


Glu Asp  Glu Thr Val Gly Arg  Arg Thr Ala Ser Ile  Gly Ser Thr 
    1655                 1660                 1665             


Thr Thr  Arg Ile Thr Gln Leu  Arg Gly Ser Ser Ser  Arg Ser Ile 
    1670                 1675                 1680             


His Asp  Gly Asn Asp Leu Arg  Leu Gly Asp Gly Glu  Ser Pro Val 
    1685                 1690                 1695             


Lys Leu  Glu Ala Val Lys Leu  Ala Glu Ser Thr Ala  Ser Gly Ser 
    1700                 1705                 1710             


Thr Met  Ala Pro Ser Pro Ala  Ile Met Gln Asp Arg  Leu Pro Pro 
    1715                 1720                 1725             


Pro Ser  Thr Ser Val Asp Val  Ala Val Pro Asn Glu  Thr Pro Val 
    1730                 1735                 1740             


Thr Val  Asn Glu Asp Val Ala  Gln Ala Lys Glu Lys  Asp Val Thr 
    1745                 1750                 1755             


Gln Leu  Gln Arg Ser Arg Gln  Asp Phe Leu Ser Ala  Arg Glu Thr 
    1760                 1765                 1770             


Asp Ile  Ile Ala Asn Met Asp  Thr Pro Pro Leu Cys  Thr Ser Ser 
    1775                 1780                 1785             


Ala Pro  Asn Ala Pro Glu Leu  Leu Asp Ser Ser Lys  Pro Pro Cys 
    1790                 1795                 1800             


Ser Ser  Ala Val Phe Ala Pro  Ile Ser Ala Ser Val  Ala Val Ala 
    1805                 1810                 1815             


Pro Val  Glu Ala Ser Arg Gly  Ser Gly Arg Ala Ala  Ala Leu Glu 
    1820                 1825                 1830             


Thr Lys  Pro Leu Ala Ala Val  Pro Pro Pro Val Ser  Pro Arg Pro 
    1835                 1840                 1845             


Gly Ser  Leu Ala Thr Leu Pro  Glu Ala Gly Glu Gly  Ala Ala Val 
    1850                 1855                 1860             


Leu Leu  Ser Pro Arg Asn Gly  Ala Leu Gly Arg Glu  Gly Asp Leu 
    1865                 1870                 1875             


Leu Gly  Arg Val His Gly Gly  Asp Ala His Glu Ala  Thr Pro Pro 
    1880                 1885                 1890             


Gly Lys  Gly Asp Val Leu Ala  Thr Thr Glu Gly Glu  Thr Ala Leu 
    1895                 1900                 1905             


Glu Val  Gly Thr Asn His Pro  Val Ser Glu Ala Lys  Asp Gly Val 
    1910                 1915                 1920             


Ala Gly  Ala His Glu Lys Ala  Arg Leu Arg Ser Glu  Gly Ala His 
    1925                 1930                 1935             


Gly Ala  Ala Val Ala Ser Cys  Glu Val Ser Ala Gly  His Arg Ser 
    1940                 1945                 1950             


Pro Pro  His Leu Pro Ala Pro  Phe His Glu Pro Arg  Pro Gln Gln 
    1955                 1960                 1965             


Gln Gln  Arg Leu Gly Thr Asn  Glu Ser Thr Trp Ser  Asp Val Glu 
    1970                 1975                 1980             


Thr Asp  Glu Ala Gln Arg Arg  Tyr Ile Arg Asp Gln  Ile Val Gln 
    1985                 1990                 1995             


Glu Glu  Ala Ala Gly Val Ile  Gln Gln Ala Trp Arg  Asp Tyr Val 
    2000                 2005                 2010             


Ala Ala  Arg Leu Arg Arg Gln  Leu His Leu Leu Trp  
    2015                 2020                 2025 


<210>  13
<211>  868
<212>  PRT
<213>  Leishmania infantum

<400>  13

Met Met Ala Ala Arg Arg Ala Ser Ser Met Asp Arg Ser Ala Val Gly 
1               5                   10                  15      


Gly Phe Asp Pro Val Ala His Tyr Ser Pro Cys Pro Pro Leu Pro Val 
            20                  25                  30          


Ile Gly Gln Pro Gln Asn Thr Ala Leu Ser Ala Gly Asp Ala Cys Pro 
        35                  40                  45              


Ala Pro His Ala Gly Leu Lys Gln His Asp Ser Gly Val Ala Val Leu 
    50                  55                  60                  


Lys Ser Ser Arg Lys Thr Ala Ser Ser Ser Pro Tyr Val Ile Thr Asp 
65                  70                  75                  80  


Lys Thr Pro Arg Ala Glu Leu Leu Ala Ile Ile Met Gln Leu Gln Ala 
                85                  90                  95      


Asp Leu Thr Gln Arg Thr Asp Ser Val Asn Ala Ile Gln Arg Asn Phe 
            100                 105                 110         


Glu Arg Leu Ser Ala Met His His Ala Glu Gln Leu Glu Leu Arg Arg 
        115                 120                 125             


Leu Arg Leu Leu Glu Lys Thr Arg Ser Glu Val Ala Pro Asp Gly Leu 
    130                 135                 140                 


Asp Ala Ala Thr Arg Gln Leu Glu Ser Val Leu Ala Glu Met Arg His 
145                 150                 155                 160 


Lys Ala Leu Glu Gln Gln Thr Thr Phe Val Gln Met Glu Val Asp Leu 
                165                 170                 175     


Gln Ala Ala Asn Ser Ser Cys Ala Leu Gln Gln Gly Ile Ala Arg Leu 
            180                 185                 190         


Ile Ala Ser His Ala Asp Gly Phe Arg Asp Val Leu Gln Ala Glu Ala 
        195                 200                 205             


Val Ala His Ser Gln Leu Tyr Gln Ser Ala Met Ser Glu Arg Ala Ile 
    210                 215                 220                 


Ile Gly Ser Arg Asn Glu Ala Thr Gln Gln Gln Leu Leu Cys Lys Asp 
225                 230                 235                 240 


Val Ala Gln Leu Val Ala Asp His Gln Ala Gln Ile Val Thr Lys Leu 
                245                 250                 255     


Ile Arg Gly Gly Ala Ala Glu Ser Cys Arg Leu Gln Lys Ser Leu Ala 
            260                 265                 270         


Gln Val Ser Thr Ala Thr Val Gln Glu Leu Val Arg Gln Gly Leu Arg 
        275                 280                 285             


Glu Thr Ala Glu Ala Val His Gln Tyr Val Ala Ser Ile His Ala Ala 
    290                 295                 300                 


Asp Gln Glu Arg Val Leu Ala Glu Ala Glu Gly Gln Arg Asp Arg Glu 
305                 310                 315                 320 


Arg Leu Arg Leu Ala Leu Gly Glu Leu Leu Arg Leu Arg Leu Arg Ala 
                325                 330                 335     


Thr Glu Glu Ala Glu Ala Thr Ala Arg Gln Ala Leu Leu Phe Gly Ala 
            340                 345                 350         


Leu Gln Ala Cys Ala Thr Ala Gln Arg Ala Ala Glu Glu Val Arg Leu 
        355                 360                 365             


Leu Thr Ala Asn Ala Asp Ala Ala Ala Ala Ala Thr Arg Ser Ser Trp 
    370                 375                 380                 


Glu Val Thr Ala Ala Leu Leu Thr Arg Arg Val Ser Asp Trp His Asp 
385                 390                 395                 400 


Ala Ala Asp Met Arg Leu Val Asp Phe His Asp Thr Ile Glu Ala Ser 
                405                 410                 415     


Met Ala Glu Lys Ala Arg Glu Arg Asp Ala Gln Ser Gln Gln Lys Thr 
            420                 425                 430         


Gln Glu Leu Leu Leu Glu Glu Arg Lys Arg Leu Glu Asn Leu His Ala 
        435                 440                 445             


Ser Gln Met Gln Thr Met Gln Val Asp Trp Arg Arg Gln Arg Asp Ala 
    450                 455                 460                 


Val Gln Gln Ser His Ala Met Gln Leu Glu Gln Val Arg Ser Asp Leu 
465                 470                 475                 480 


Val Ala Gln Val Gln Val Ala Glu Asp Arg Arg Val Ala Ala Glu Arg 
                485                 490                 495     


Arg Thr Gly Ala Met Glu Ala Ala Leu Ile Gln Leu Lys Arg Asp His 
            500                 505                 510         


Ala Ala Glu Val Gln Ala Val Glu Ala His Trp Arg Ser Ala Val Ser 
        515                 520                 525             


Asp Ala Gly Arg His Cys Glu Gln Arg Trp Arg Thr Met Leu Glu Val 
    530                 535                 540                 


Tyr Gln Glu Gly Gln Lys Ala His Arg Gly Ala Met Leu Gln Leu Phe 
545                 550                 555                 560 


Val Asp Phe Leu Cys Thr Arg Gly Gln Cys Val Tyr Glu Glu Gln Ala 
                565                 570                 575     


Glu Arg Ala Ala Leu Cys Arg Ser His Trp Arg Asn Gln Thr Gln His 
            580                 585                 590         


Leu Arg Glu Glu Gln Ala Ala Val Met Gln His Gly Val Ala Thr Ala 
        595                 600                 605             


Asp Leu Leu Glu Arg Met Arg Cys His Lys Glu Asp Glu Ala Ala Ser 
    610                 615                 620                 


Arg Ala Val Leu His Ala Ser Glu Ala Ser Asp Trp Ala Ala Leu Val 
625                 630                 635                 640 


Arg Lys Glu Ala Ala His Asn Ala Gln Ala His His Ala Val Ser Met 
                645                 650                 655     


Ala Ala Ala Ala Ala Gly Leu Glu Gly Leu Arg Ala Glu Met Ala Gly 
            660                 665                 670         


Arg Glu Val Arg Trp Gly Gln Arg Leu Asp Ala Leu Glu Ala Asp Leu 
        675                 680                 685             


Arg Arg Ala Gln Gln Lys Cys Leu Gly Val Val Arg Arg Ala Ser Asp 
    690                 695                 700                 


Ala Val Val Ala Ala Gln Glu Ala Gln Ala Ala Leu Gln Ala Thr Gln 
705                 710                 715                 720 


Arg Asp Phe Ala Ala Tyr Arg Cys Gly Val Ser Ala Ala Ala Gln Arg 
                725                 730                 735     


Ile Glu Val Ala Glu Ser Ala Thr Glu Ser Ala Cys Cys Cys Ser Leu 
            740                 745                 750         


Cys Leu Gln Leu Tyr Cys Gln Pro Val Ala Cys Val Pro Cys Gly His 
        755                 760                 765             


Ile Tyr Cys Ala Asn Cys Leu Leu Arg His Ala Arg Asn Arg Ser Leu 
    770                 775                 780                 


Ser Ser Val Thr Ser Ser Phe Ala Ser Ala Ala Gly Ala Ser Thr Ser 
785                 790                 795                 800 


Glu Asn Gly Ala Val Gly Ala Arg Ala Ala Leu Glu Val Thr His Trp 
                805                 810                 815     


Leu Arg Gly Lys Ser Thr Pro His Ala Phe Leu Phe Cys Pro Glu Cys 
            820                 825                 830         


Ala Ser Ala Thr Val Ser Thr Val Val Glu Leu Pro Ile Leu Gly Glu 
        835                 840                 845             


Leu Thr Ala Lys Tyr Asp Tyr Lys Lys Arg Ser Leu Ala Val Leu Leu 
    850                 855                 860                 


Ala Glu Leu Arg 
865             


<210>  14
<211>  708
<212>  PRT
<213>  Leishmania infantum

<400>  14

Met Glu Thr Leu Leu His Arg Ser Cys Val Pro Ala Thr Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ala Glu Leu Ser Phe Leu Glu Lys Ser Arg His Phe Ser Pro 
            20                  25                  30          


His Glu Ser Gly Ala Ile Arg Ile Thr Ser Ser Ser Leu Arg Thr Ser 
        35                  40                  45              


Asp Leu Ser Ser Leu Cys Leu Asn Ile Val Pro Gln Arg Glu Arg Thr 
    50                  55                  60                  


Gly Ser Val Gly Val Arg Leu Ser Ala Ser Ile Ile His Tyr Ser Pro 
65                  70                  75                  80  


Ala Arg Met Leu Pro Glu Ser Pro Ser Arg Val Asp Thr Leu Ala Arg 
                85                  90                  95      


Asp Ala Val Lys Asn Cys Glu Gln Gln Leu Lys Gln Glu Glu Glu Pro 
            100                 105                 110         


Phe Gly Ser Ser Tyr Arg Glu Val Glu Glu Arg Arg Ala Ser Lys Ala 
        115                 120                 125             


Leu Ala Pro Ser Gly Val Ser Asp Ala Ser Ala Thr Glu Asp Gly Ala 
    130                 135                 140                 


Arg Thr Arg Gly Ala Glu Leu Val Gly Asp Ser Asp Asp Glu Asp Val 
145                 150                 155                 160 


Tyr Asn Ser Arg Ile Ala Arg Arg Ile Arg Ala Phe Leu Glu Ser Ile 
                165                 170                 175     


Arg Glu Glu Asp Phe Thr Leu Asn Pro Pro Pro Val Asp Ala Thr Asp 
            180                 185                 190         


Met Glu Ala Asn Gly Glu Tyr Val Asp Glu Glu Thr Leu Arg Gln Gln 
        195                 200                 205             


Arg Leu Glu Arg Met Thr Val Asp Glu Met Arg Ser Ile Thr Ser Glu 
    210                 215                 220                 


Ala Gln Arg Glu Leu Leu Ile Ser Leu Tyr Asp Ala Ile Thr Leu Glu 
225                 230                 235                 240 


Thr Asp Leu Met Glu Ile Ser Glu Asp Val Ser Val Leu Lys Arg Ala 
                245                 250                 255     


Val Gly Gln Arg Asp Glu Val Ile Glu Met Leu Lys Met Gln Leu Ser 
            260                 265                 270         


Thr Ala Asp Glu Tyr Asn Glu Glu Leu His Asn Ala Lys Lys Glu Ala 
        275                 280                 285             


Leu Arg Lys Leu Ser Asp Ala Lys Thr Glu Met Ala Leu Leu Ser Gln 
    290                 295                 300                 


Arg Asn Ala Lys Leu Ser Lys Leu Leu Gln Glu Arg Glu Glu Glu Leu 
305                 310                 315                 320 


Gln Leu Ser Leu Leu Gly Gly Thr Asn Thr Leu Ala Gly Ala Leu Leu 
                325                 330                 335     


Pro Ala Pro Glu Arg Arg Asp Glu Gly Thr Ile Thr Thr Glu Ala Pro 
            340                 345                 350         


Arg Ser Val Val Thr Ala Asp Ser Ala Ser Val Gly Val Phe Asn Lys 
        355                 360                 365             


Gly Ser Cys Ser Thr Leu Ser Ser Pro Thr Gln His Arg Leu His Glu 
    370                 375                 380                 


Leu Glu Glu Met Leu Trp Lys Leu Gln Cys Leu Arg Asp Val Leu His 
385                 390                 395                 400 


Ser Lys Glu Lys Ala Lys Asp Asp Leu Asp Gln Gln Val Trp Gln Leu 
                405                 410                 415     


Ala Met Ser Val Lys Gly Ser Arg Ala Ala Ala Ala Ser Ser Ala Ser 
            420                 425                 430         


Pro Asn Gly Gly Asp Gly Phe Cys Gln Leu Gln Gly Val Ser Asp Ala 
        435                 440                 445             


Ser Thr Glu Val Gly Cys Met Pro Arg Cys Arg Cys Lys Glu Ala Ala 
    450                 455                 460                 


Gly Cys Ala Asp Ser Leu Glu Glu Ala Gln Ile Leu Arg Val Lys Val 
465                 470                 475                 480 


Leu Ala Gln Gly Ala Asn Thr Arg Gly Ala Lys Thr Arg Gly Val Ser 
                485                 490                 495     


Arg Arg Glu Ile Ala Thr Lys Thr Glu Ile Ala Ser Gln Lys Gln Leu 
            500                 505                 510         


Val Gly Ser Ser Gly Leu Val Ser Thr Ser Thr Thr Ala Pro Pro Gly 
        515                 520                 525             


Gln Gly Gly Ser Cys Gly Cys Gly Ala Pro Ala Gly Ala Asn Leu Ala 
    530                 535                 540                 


Leu Leu Gln Arg Gln Leu Asp Arg Ala Gln Ala Asp Ala Arg Arg Leu 
545                 550                 555                 560 


Glu Ser Glu Leu Arg Ala Glu Arg Glu Lys Ser Gln Arg Gln Ser Val 
                565                 570                 575     


Thr Glu Lys Lys Leu Leu Glu Asn Val Thr Ser Leu Ala Gln Gln Leu 
            580                 585                 590         


Arg Ala Arg Glu Ala Leu Asp Arg Glu Thr Arg Arg Gln Arg Arg Ala 
        595                 600                 605             


Gln Gln Ser Gly Thr Arg Gly Asp Asp Gly Gly Ala Ala Glu Gly Arg 
    610                 615                 620                 


Arg Thr Leu Phe Tyr Pro Ser Arg Phe Ser Leu Gly Asp Arg Ala Gly 
625                 630                 635                 640 


Val Arg Arg Glu Ala Ser Ala Val Ala Glu Asp Val His Asp Gly Ala 
                645                 650                 655     


Val Ser Thr Trp Ala Pro Cys Ser Val Asn Arg Val Ser Gly Asp Val 
            660                 665                 670         


Gly Val Gly Ala Ala Ala Val Thr Ser Arg Thr Ser His Ala Ser Ser 
        675                 680                 685             


Pro Glu Leu Arg Arg Arg Arg Glu Ser Ile Phe Ala Ser Leu Arg Asp 
    690                 695                 700                 


Ala His Thr Thr 
705             


<210>  15
<211>  2179
<212>  PRT
<213>  Leishmania infantum

<400>  15

Met Pro Ala His Gln Gln Leu Pro His Pro Ser Leu Thr Arg Ala Ser 
1               5                   10                  15      


Glu Gly Val Ser His Val Ala Ser Thr Gly His Ser Ser Arg Val Ser 
            20                  25                  30          


Gln Asp Val Arg Gln Ala Arg Ala Gln His Ala Phe Asp Ala Gln Ala 
        35                  40                  45              


Ser Glu Leu Glu Gln Gln Leu Asp Gly Gln Leu Glu Leu Val Phe Thr 
    50                  55                  60                  


Leu Met Arg Arg Ile Met Val Leu Asp Ala His Leu Ala Ala Arg Ser 
65                  70                  75                  80  


Thr Ala Gly Thr Ser Thr Thr Leu Ala Ser Ser Gly Ala Asp Thr Glu 
                85                  90                  95      


Asp Tyr Arg Glu Leu Leu Val Gly Gln Leu Glu Glu Val Glu Asp Val 
            100                 105                 110         


Thr Val Ser Thr Ala Leu His Phe Val Glu Leu Ala Asn Arg His Ala 
        115                 120                 125             


Leu Glu Trp Met Asn His Gly Gln Tyr Ser Ala Ala Leu Gln Leu Leu 
    130                 135                 140                 


Gln Arg Ala Asp Arg Leu Leu Arg Lys Asp Thr Gly Arg Val Phe Arg 
145                 150                 155                 160 


Tyr Leu Pro Asp Pro Leu Glu Leu Glu Ala Pro Ser Thr Ser Asp Ala 
                165                 170                 175     


Ala Gly Gly Cys Asn Gly Leu Arg Asp Gly Arg Asp Thr Thr Ser Leu 
            180                 185                 190         


Gln Arg Pro Ala Ala Ala Ser Ala Gln Ala Arg Ser His Asp Arg Lys 
        195                 200                 205             


Cys Pro Ala Met Leu Thr Ser Ser Asp Ser Gly Ala Ser Ile Asn His 
    210                 215                 220                 


Ile Ser Ser Asp Ser Val Cys Ser Ile Ser Val Pro Phe Phe Ser Pro 
225                 230                 235                 240 


Ser Gln Glu Pro Arg Arg Leu Lys Ala Val Ala Ala Val Ala His Asn 
                245                 250                 255     


Leu Gly Val Tyr His Phe Lys Leu Gly Glu Tyr Lys Leu Ala Ser Ala 
            260                 265                 270         


Leu Phe Ala Arg Ser Ala Ala Leu Glu Glu Glu Leu Gln Ala Pro Gly 
        275                 280                 285             


Ile Gly Ile Thr Tyr Phe Asn Met Ala Gln Ala Gln Asp Gly Leu Gly 
    290                 295                 300                 


Gln Leu Thr Glu Ala Leu Arg Tyr Ala Glu Leu Ala Glu Glu Ala Val 
305                 310                 315                 320 


Glu Arg Gln Val Phe Gln Ala Lys Asp Lys Thr Thr Arg Met Arg Arg 
                325                 330                 335     


Arg Leu Thr Gln Gly Arg Ala Phe Gln Ala Arg Asp Phe Pro Asp Gly 
            340                 345                 350         


Ala Cys Ala Ala Ser Arg Gly Gly Glu Asp Asn His Asp Gly Asp Thr 
        355                 360                 365             


Ala Ala Val Asn Ala Ser Thr Gly Gly His Arg Tyr Ser Asp Ala Ala 
    370                 375                 380                 


Ala Thr Ile Asp Gly Glu Glu Glu Lys Ala Leu Met Arg Met Trp Leu 
385                 390                 395                 400 


Gln Trp Arg Glu Ser Val Cys Phe Leu Ser Tyr Val Lys Gln Ser His 
                405                 410                 415     


Ala Gly Trp Leu Gly Gly Met Gly Leu Tyr Lys Glu Ala Tyr Gln His 
            420                 425                 430         


Tyr Gln Gln Ala His Arg Trp Leu Leu Ala Ile Pro His Leu Ala Thr 
        435                 440                 445             


Glu Glu Gln Gln Arg Ala Gln Leu Leu Lys Gln Tyr Met Ala Thr Met 
    450                 455                 460                 


Lys Thr Arg Trp Arg Arg Glu Glu Ile Glu Glu Glu Leu Tyr Asn His 
465                 470                 475                 480 


Pro Leu Arg Thr Ser Ser Ala Ala Ser Ser Gly Ala Val Pro Ala Val 
                485                 490                 495     


Ser Tyr Pro Ser His Asn Thr Arg Ala Pro Ser Lys Leu Arg Ala Arg 
            500                 505                 510         


Ala His Gln Arg Pro Gln Leu Ser Pro Ala Ala Leu Ser Gly Ala Val 
        515                 520                 525             


Pro Ile Ala Lys Asp Phe Thr Ser Pro Leu Gln Ser Thr Val Val Thr 
    530                 535                 540                 


Ser Val Leu Pro Arg Asn Val Glu Val Val Gly Arg Arg Pro Ser Gly 
545                 550                 555                 560 


Pro Ser Arg Ala Phe Tyr Arg Glu Ser Phe Pro Thr Pro Asn Glu Ala 
                565                 570                 575     


Pro Phe Leu Trp Pro Ser Ala Asn Ala Val Val Gln Arg Asn Ser Met 
            580                 585                 590         


Ser Ala Gln Leu Arg Arg Arg Pro Ser Ser Ala Asn Ala Val Leu His 
        595                 600                 605             


Ser Leu Tyr Ala Pro Arg Arg Pro Ser Ala Ser Ser Leu Arg His Arg 
    610                 615                 620                 


His Ser Ala Thr Asp His Ala Ile Ala Ser Ala Glu Gln Asp His Thr 
625                 630                 635                 640 


Pro Leu Ser His Pro Pro Gln Glu Pro Arg Gln Gln Gln Gln Gln Gln 
                645                 650                 655     


Gln His Gly Gly Lys Arg Ala Ser Trp Asp Pro Ser Met Arg Val Pro 
            660                 665                 670         


Ile Pro Pro Pro Gly Arg Arg Thr Glu Tyr Arg Thr Pro Ala Gly Arg 
        675                 680                 685             


Ala Gly Pro Ala Ala Pro Gly Pro Leu Leu Arg Arg Ser Ser Ala Ser 
    690                 695                 700                 


Leu Leu Arg Ser Asn Ala Gly Glu Leu Glu Val Phe Thr Thr Ala His 
705                 710                 715                 720 


Leu Thr Pro Arg Ala Ser Ser Thr Pro Tyr Asp Ala His Thr Arg Phe 
                725                 730                 735     


Ala Ser Gln His His Pro Ser Pro Pro Arg Glu Pro Ala Pro Val Ser 
            740                 745                 750         


Ser Thr Ser Ala Glu Ser Cys Val Val Arg Gly Leu Ile Phe Glu Ala 
        755                 760                 765             


Val Pro Glu Thr Pro Lys Ser Leu Pro His Arg His His Ser Glu Leu 
    770                 775                 780                 


Ala Val Pro Asp Ala Leu Thr Val Glu Arg Val Lys Glu Val Ala Ala 
785                 790                 795                 800 


Asp Pro Pro Gly Gln Arg Arg Glu Ser Ala Ala Thr Pro Lys Lys Asp 
                805                 810                 815     


Ser Val Gly Asp Gly Ala Thr Asp Leu Ala Ala Trp Ala Pro Pro Ala 
            820                 825                 830         


Ala Arg Gln Leu Pro Asp Leu Thr Pro Ser Pro Arg Ile Pro Gly Asp 
        835                 840                 845             


Leu Thr Trp Cys Val Thr Val Leu Gln Ala Phe Leu Arg Pro Arg Cys 
    850                 855                 860                 


His His Arg Thr Leu Ser Gly Thr Glu Gly Glu Arg Asp Arg Gly Lys 
865                 870                 875                 880 


His Ala Asp Arg Gly Arg Asn Thr Ile Glu Ser Pro Gln Arg Ser Cys 
                885                 890                 895     


Pro Ala Glu Ala Ser Thr Val Lys Ser Glu Ser Pro Ser Arg Ala Ala 
            900                 905                 910         


Asp Val Glu Lys Ala Thr Ile Leu Asp Gly Asp Gly Thr Ser Arg Asp 
        915                 920                 925             


Ala Gln Ser Leu Ser Leu Ser Ser Lys Ser Val Gly Ala Leu Thr Val 
    930                 935                 940                 


Arg Arg Ala Glu Leu Gln Ala Ser Gln Pro Cys Ser Ala Gly Val Tyr 
945                 950                 955                 960 


Gly Ala Leu Val Ser Gly Thr Thr Val Gly Arg Ala Pro Gly Ser Lys 
                965                 970                 975     


Ser Ala Thr Gln Pro Ser Leu Ser Ala Ser Ser Ser Ser Cys Ala Ala 
            980                 985                 990         


Val Arg Arg Thr Ala Cys Val Glu  Ser Gly Gly Leu His  Ala Glu Ala 
        995                 1000                 1005             


Ala Val  Thr Ser Asn Glu Asp  Ile Asn Ala Ser Ala  Arg His Asp 
    1010                 1015                 1020             


Gly Ala  Asp Val Cys Val Asp  Leu Ala Ala Ala Glu  Arg Glu Trp 
    1025                 1030                 1035             


Pro Ser  Ser Pro Ala Arg Asp  Asp Ala Ser Ala Gly  Gln His Ala 
    1040                 1045                 1050             


Gly Met  Gly Ser Leu Gly Val  Gly Tyr Gly Gly His  Val Ala Val 
    1055                 1060                 1065             


Glu Ala  Val Met Lys Arg Arg  Arg Ser Val Ile Pro  Tyr Glu Ser 
    1070                 1075                 1080             


Asp Asp  Gly Glu Ala Ser Gly  Pro Thr Ser Pro Asp  Arg Phe Tyr 
    1085                 1090                 1095             


Ser Lys  Gly Phe His Asp Ala  Gly Asn Ser Ala Gly  Ala Ala Ala 
    1100                 1105                 1110             


Pro Thr  Ala Lys Arg Val Tyr  Val Val Thr Ser Asp  Ser Gly Ala 
    1115                 1120                 1125             


Thr Thr  Thr Ala Ala Ser Ala  Pro Phe Pro Val His  His Glu Lys 
    1130                 1135                 1140             


Asn Asp  Gly Glu Lys Asp Phe  Leu His Glu Pro Ser  Leu Gly Gly 
    1145                 1150                 1155             


Asp Glu  Val Met Leu Lys Leu  Glu Ser Leu Asp Ser  Glu Arg Arg 
    1160                 1165                 1170             


Ser Cys  Met Pro Val Ser Ala  Asp Ala Leu Val Gly  Arg Glu Gly 
    1175                 1180                 1185             


Asp Arg  Cys Cys Gly Asp Ala  Ser Ala Ser Thr Ser  Lys Thr Ser 
    1190                 1195                 1200             


Ala His  Asp Ile Ser Gly Lys  Gly Glu Ser Asp Ala  Val Ala Thr 
    1205                 1210                 1215             


Val Ala  Glu Glu Arg Glu Asp  Ala Pro Gly Asn Ala  Pro Val Leu 
    1220                 1225                 1230             


Glu Thr  Cys Ala Ser Val Ser  Lys Glu Ala Lys Ala  Asn Ser Leu 
    1235                 1240                 1245             


Ser Ala  Leu Gln Arg Leu Asn  Thr Gly Asp Gln Lys  Ile Thr Val 
    1250                 1255                 1260             


Glu Ala  Ser Pro Ala Met His  Ala His Glu Lys Asp  Gln His Leu 
    1265                 1270                 1275             


Val Cys  Glu Ala Glu Gly Arg  Gly Thr Ala Ala Gln  Arg Thr Ala 
    1280                 1285                 1290             


Ser Pro  Phe Arg Ala Ser Val  Asp Gly Val Leu Arg  Ala Glu Gln 
    1295                 1300                 1305             


Ala Glu  Leu Ala Cys Ala Ala  Val Ala Val Ala Gly  Ser Leu Ser 
    1310                 1315                 1320             


Ala His  Gln Leu Ala Ile Leu  Asn Lys Val Ala Ser  Ser Val Ala 
    1325                 1330                 1335             


Thr Val  Ala Glu Ala Phe Ala  Ser Ala Ala Asp Asp  Tyr Gly Asp 
    1340                 1345                 1350             


Val Pro  Lys Pro Ser Phe Leu  Ser Pro Thr Ser Ser  Ala Ala Cys 
    1355                 1360                 1365             


Arg Gly  Thr Arg Ala Pro Phe  Gln Ser Ser Arg Asp  Pro Gly Val 
    1370                 1375                 1380             


Arg Glu  Gly Glu Leu Lys Ala  Val Ser Ala Ser Ala  Ala Leu Ser 
    1385                 1390                 1395             


His Ser  Ser His Ser Pro Val  Ser Gln Ala Pro Gln  Glu Thr Ser 
    1400                 1405                 1410             


Arg Asn  Val Asp Gln Val Asp  Gly Ser Cys Ser Ala  Gly Leu Gly 
    1415                 1420                 1425             


Ala Ala  Gly Glu Glu Glu Ala  Ser Asn Val Cys Thr  Ala Ala His 
    1430                 1435                 1440             


Ala Ile  Leu Ser Asp Arg Ser  Arg Glu Asp Asp Leu  Gly Asp Arg 
    1445                 1450                 1455             


Thr Ala  Val Gln Lys Thr Ala  Leu Ser Asp Ser Pro  Thr Pro Pro 
    1460                 1465                 1470             


Phe Thr  Ser Ser Val Cys Ala  Glu Asn Val Cys Pro  Ser Ser Leu 
    1475                 1480                 1485             


Glu Asp  Thr Ala Leu Pro Gly  Gly Ser Ser Met Arg  Ala Ser Ile 
    1490                 1495                 1500             


Ser Ala  Thr Ala Val Arg Phe  Thr Ala Cys Gly His  Glu Ala Pro 
    1505                 1510                 1515             


Lys Arg  Met Ser Ser Ser Ala  Ser Val Cys Pro Val  Asp Leu Glu 
    1520                 1525                 1530             


Val Glu  Gly Asp Asn Gly Pro  Ala Ser Glu Ala Leu  Arg Gln Glu 
    1535                 1540                 1545             


Thr Glu  Glu Ala Gly Gly Ser  Ala Leu His Lys Gly  Ser Ser Ala 
    1550                 1555                 1560             


Ala Pro  Gly Ala Ser Ala Ala  Ser Ala Gly Arg Ala  Ala Ser Ser 
    1565                 1570                 1575             


Ser Arg  Glu Ala Val Ser Trp  Thr Glu Val Lys Gly  Ala Thr Asn 
    1580                 1585                 1590             


Ala Leu  Ala Val Thr Val Ala  Thr Pro Ser Ala Glu  Thr Glu Glu 
    1595                 1600                 1605             


Gln Leu  Thr Thr Pro Ala Asp  Lys Asp Gly His Pro  His Glu Gln 
    1610                 1615                 1620             


Ser Arg  Ala Ala Thr Leu Phe  Ser Ser Pro Ser Arg  Met Arg Glu 
    1625                 1630                 1635             


Ser Cys  Arg Gly Asp Ser Ser  Met Thr Thr Ser Ala  Ala Arg Pro 
    1640                 1645                 1650             


Pro His  Asn Glu Val Ala Asp  Leu Pro Leu Ser Glu  Asp Pro Ala 
    1655                 1660                 1665             


Ser Gly  Lys Val Thr Ala Glu  Glu Gln Ser Ala Glu  Val Ser Ala 
    1670                 1675                 1680             


Ala Ile  Lys Glu Gly Arg Ser  Pro Glu Glu Val Val  Met Ala Pro 
    1685                 1690                 1695             


Pro Pro  Arg Arg Ser Arg Val  Phe Val Phe Ala Pro  His Lys Leu 
    1700                 1705                 1710             


Ala Ala  Ser Ala Ser Met Glu  Leu Arg Asn Val Asp  Phe Ser Phe 
    1715                 1720                 1725             


Arg Ser  Gly Asp Ala Gly Glu  Gln Leu Arg Ser Pro  Thr Arg Met 
    1730                 1735                 1740             


Pro Lys  Gln Pro Ala Ala Thr  Leu Asp Thr Glu Thr  Val Glu Asp 
    1745                 1750                 1755             


Gly Ala  Ala Lys Pro Val Leu  Leu Arg Leu Ala Gly  Gly Ser Arg 
    1760                 1765                 1770             


Thr Ser  Gly Ser Ser Asn Asp  Ser Leu Cys Phe Asn  Glu Gly Tyr 
    1775                 1780                 1785             


Cys Cys  Pro Ala Pro Met Met  Ala Tyr Ala Thr Thr  Glu Asp Glu 
    1790                 1795                 1800             


Thr Leu  Gly Arg Arg Thr Thr  Ser Ile Ser Ser Thr  Thr Thr Arg 
    1805                 1810                 1815             


Ile Thr  Gln Leu Arg Gly Ser  Ser Ser Arg Ser Ile  His Asp Gly 
    1820                 1825                 1830             


Asn Asp  Leu Arg Pro Gly Asp  Gly Glu Ser Pro Gly  Asn Asn Glu 
    1835                 1840                 1845             


Arg Arg  Leu Leu Val Lys Pro  Glu Ala Val Glu Leu  Val Lys Thr 
    1850                 1855                 1860             


Thr Ala  Pro Val Ser Ala Thr  Ala Pro Ser Pro Ala  Ile Met Gln 
    1865                 1870                 1875             


Asp Gly  Leu Pro Met Pro Ser  Ala Ser Val Asp Val  Ala Val Pro 
    1880                 1885                 1890             


Ser Glu  Ala Pro Val Met Val  Lys Glu Asp Ile Ala  Gln Val Glu 
    1895                 1900                 1905             


Glu Lys  Asp Val Lys Gln Leu  Gln Arg Ala Arg Gln  Asp Leu Phe 
    1910                 1915                 1920             


Ser Thr  His Glu Ile Asp Ile  Met Lys Asn Met Asp  Thr Ser Pro 
    1925                 1930                 1935             


Pro Cys  Thr Thr Ser Ala Pro  Asn Thr Pro Glu Leu  Leu Asp Ser 
    1940                 1945                 1950             


Ser Lys  Leu Thr Cys Ser Ser  Pro Val Phe Ala Pro  Ile Ala Ala 
    1955                 1960                 1965             


Ser Ala  Ala Val Ala Pro Val  Glu Ala Pro Arg Gly  Pro Gly Ser 
    1970                 1975                 1980             


Ala Val  Glu Leu Glu Met Lys  Leu Ser Thr Ala Val  Pro Pro Ser 
    1985                 1990                 1995             


Ile Ser  Leu Arg Pro Glu Ser  Pro Val Pro Leu Pro  Lys Pro Gly 
    2000                 2005                 2010             


Glu Arg  Ser Ala Gly Leu Leu  Ser Pro Arg Asn Cys  Pro Leu Asp 
    2015                 2020                 2025             


Arg Glu  Gly Asp Leu Leu Gly  Arg Val His Gly Gly  Asp Ala Asp 
    2030                 2035                 2040             


Glu Ala  Thr Pro Pro Gly Met  Gly Asp Val Leu Ala  Thr Thr Glu 
    2045                 2050                 2055             


Gly Glu  Thr Ala Leu Glu Val  Gly Ala Asn His Pro  Val Asn Gly 
    2060                 2065                 2070             


Val Lys  Asp Gly Val Ala Gly  Ala His Glu Lys Ala  Arg Leu Lys 
    2075                 2080                 2085             


Ser Glu  Gly Ala His Gly Ala  Ala Val Ala Ser Cys  Glu Val Ser 
    2090                 2095                 2100             


Ala Gly  His Leu Leu Pro Pro  His Leu Pro Ala Pro  Val His Lys 
    2105                 2110                 2115             


Pro Arg  Pro Gln Gln Gln Arg  Leu Gly Thr Asn Gly  Ser Thr Trp 
    2120                 2125                 2130             


Ser Asp  Ala Glu Thr Asp Glu  Ala Gln Arg Arg Tyr  Ile Arg Asp 
    2135                 2140                 2145             


Gln Ile  Val Gln Glu Glu Ala  Ala Gly Val Ile Gln  Gln Ala Trp 
    2150                 2155                 2160             


Arg Glu  Cys Val Ala Ala Arg  Met Arg Arg Arg Leu  His Leu Leu 
    2165                 2170                 2175             


Trp 
    


<210>  16
<211>  295
<212>  PRT
<213>  Leishmania infantum

<400>  16

Met Arg Glu Ala Ile Cys Ile His Ile Gly Gln Ala Gly Cys Gln Val 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Phe Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Ser Met Pro Ser Asp Lys Cys Ile Gly Val Glu Asp Asp Ala 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Cys Ile Phe Leu Asp Leu Glu Pro Thr Val Val Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe Asn Pro Glu Gln Leu Val Ser Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Val Asp Leu Ala Leu Asp Arg Ile Arg Lys Leu Ala Asp Asn 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Met Val Phe His Ala Val Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Leu Gly Ala Leu Leu Leu Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Gly Tyr Thr Val Tyr Pro Ser Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Cys Val Leu Ser Thr His 
            180                 185                 190         


Ser Leu Leu Glu His Thr Asp Val Ala Thr Met Leu Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Leu Thr Arg Arg Ser Leu Asp Ile Glu Arg Pro Ser Tyr 
    210                 215                 220                 


Thr Asn Val Asn Arg Leu Ile Gly Gln Val Val Ser Ser Leu Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Val Leu Thr Ser Tyr 
            260                 265                 270         


Ala Pro Val Val Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Asp Ile Thr Asn Ser Val 
    290                 295 


<210>  17
<211>  302
<212>  PRT
<213>  Leishmania infantum

<400>  17

Met Ser Ser Asp Lys Asn Val Leu Ser Ile Gln Ser His Val Thr His 
1               5                   10                  15      


Gly Tyr Val Gly Asn Lys Ala Ala Thr Phe Pro Leu Gln Leu His Gly 
            20                  25                  30          


Phe Asp Val Asp Ala Ile Asn Thr Val Ser Leu Ser Asn His Ser Gly 
        35                  40                  45              


Tyr Pro Val Ile Lys Gly His Arg Met Asp Leu Thr Glu Phe Thr Thr 
    50                  55                  60                  


Leu Leu Asp Gly Leu Arg Ala Asn Asp Phe Leu Ser Asp Tyr Ala Tyr 
65                  70                  75                  80  


Val Leu Thr Gly Tyr Ile Asn Asn Ala Asp Ile Ile Arg His Val Ala 
                85                  90                  95      


Ala Thr Val Ala Glu Val Arg Glu Lys Arg Gln Gln Gln Gly Lys Lys 
            100                 105                 110         


Asp Ile Val Phe Phe Cys Asp Pro Val Met Gly Asp Asp Gly Arg Leu 
        115                 120                 125             


Tyr Cys Lys Glu Glu Val Val Ala Ala Tyr Arg Glu Leu Val Ala His 
    130                 135                 140                 


Ala Asn Ile Ala Thr Pro Asn Tyr Phe Glu Ala Ser Ile Leu Ser Thr 
145                 150                 155                 160 


Val Glu Val Lys Asp Leu Met Ser Ala Ile Glu Ala Ala Asn Trp Phe 
                165                 170                 175     


His Glu Gln Gly Thr Pro Thr Val Val Ile Lys Ser Phe Thr Met Pro 
            180                 185                 190         


Asp Asp Pro Thr His Leu Arg Phe Leu Leu Ser Cys His Asp Lys Val 
        195                 200                 205             


Thr Gly Ser Thr Lys Arg Tyr Thr Gly Val Val Gln Tyr Tyr Glu Gly 
    210                 215                 220                 


Arg Tyr Thr Gly Thr Gly Asp Val Phe Ala Ala Ser Leu Val Ala Phe 
225                 230                 235                 240 


Ala His Asn His Pro Ile Asp Leu Ala Val Gly Lys Ala Met Gly Val 
                245                 250                 255     


Leu Gln Asp Leu Ile Lys Ala Thr Val Glu Arg Gly Gly Ser Gly Lys 
            260                 265                 270         


Ala Thr Leu Asn Ser Arg Glu Leu Arg Val Thr Ser Asp Pro Asp Arg 
        275                 280                 285             


Leu Leu His Pro Ser Thr Val Ile Ser Val Thr Pro Leu Pro 
    290                 295                 300         


