                         SEQUENCE LISTING

<110>  argenx BVBA
 
<120>  ANTI-IL-22R ANTIBODIES

<130>  P144494WO00

<150>  GB1612337.4
<151>  2016-07-15

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  llama glama

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  2
<211>  5
<212>  PRT
<213>  llama glama

<400>  2

Ser Tyr Asp Met Ser 
1               5   


<210>  3
<211>  14
<212>  PRT
<213>  llama glama

<400>  3

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  4
<211>  17
<212>  PRT
<213>  llama glama

<400>  4

Ser Ile Tyr Asn Asp Gly Ser Asn Thr Ala Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  32
<212>  PRT
<213>  llama glama

<400>  5

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  6
<211>  11
<212>  PRT
<213>  llama glama

<400>  6

Val Gly Phe Ser Gly Thr Tyr Tyr Ser Glu Ser 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  llama glama

<400>  7

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  8
<211>  30
<212>  PRT
<213>  llama glama

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly 
            20                  25                  30  


<210>  9
<211>  5
<212>  PRT
<213>  llama glama

<400>  9

Ser Tyr Phe Met Ser 
1               5   


<210>  10
<211>  14
<212>  PRT
<213>  llama glama

<400>  10

Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser 
1               5                   10                  


<210>  11
<211>  17
<212>  PRT
<213>  llama glama

<400>  11

Gly Ile His Ile Ser Gly Gly Ile Thr Tyr Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  32
<212>  PRT
<213>  llama glama

<400>  12

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Val Thr 
            20                  25                  30          


<210>  13
<211>  14
<212>  PRT
<213>  llama glama

<400>  13

Pro Pro Gly Pro Phe Lys Ala His Tyr Asn Gly Met Lys Tyr 
1               5                   10                  


<210>  14
<211>  11
<212>  PRT
<213>  llama glama

<400>  14

Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  22
<212>  PRT
<213>  llama glama

<400>  15

Asn Phe Met Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Thr Ala Lys Ile Thr Cys 
            20          


<210>  16
<211>  7
<212>  PRT
<213>  llama glama

<400>  16

Gln Gly Gly Tyr Tyr Ala His 
1               5           


<210>  17
<211>  15
<212>  PRT
<213>  llama glama

<400>  17

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
1               5                   10                  15  


<210>  18
<211>  7
<212>  PRT
<213>  llama glama

<400>  18

Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210>  19
<211>  20
<212>  PRT
<213>  llama glama

<400>  19

Asn Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu Asp Glu Ala 
1               5                   10                  15      


Glu Tyr Tyr Cys 
            20  


<210>  20
<211>  10
<212>  PRT
<213>  llama glama

<400>  20

Gln Ser Gly Ser Ser Ser Ala Asn Ala Val 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  llama glama

<400>  21

Phe Gly Gly Gly Thr His Leu Thr Val Leu 
1               5                   10  


<210>  22
<211>  22
<212>  PRT
<213>  llama glama

<400>  22

Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys 
            20          


<210>  23
<211>  14
<212>  PRT
<213>  llama glama

<400>  23

Thr Gly Thr Ser Arg Asp Ile Gly Asp Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  24
<211>  15
<212>  PRT
<213>  llama glama

<400>  24

Trp Tyr Gln Gln Leu Pro Gly Leu Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  25
<211>  7
<212>  PRT
<213>  llama glama

<400>  25

Lys Val Asn Thr Arg Ser Ser 
1               5           


<210>  26
<211>  20
<212>  PRT
<213>  llama glama

<400>  26

Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala 
1               5                   10                  15      


Asp Tyr Tyr Cys 
            20  


<210>  27
<211>  10
<212>  PRT
<213>  llama glama

<400>  27

Ala Ser Tyr Arg Leu Tyr Ala Asp Tyr Val 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  llama glama

<400>  28

Phe Gly Gly Gly Thr His Leu Thr Val Leu 
1               5                   10  


<210>  29
<211>  120
<212>  PRT
<213>  llama glama

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Asn Asp Gly Ser Asn Thr Ala Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Phe Ser Gly Thr Tyr Tyr Ser Glu Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  103
<212>  PRT
<213>  llama glama

<400>  30

Asn Phe Met Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Thr Ala Lys Ile Thr Cys Gln Gly Gly Tyr Tyr Ala His Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Asn Asn Asn 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Ser Ser Gly Asn 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu Asp Glu Ala Glu 
65                  70                  75                  80  


Tyr Tyr Cys Gln Ser Gly Ser Ser Ser Ala Asn Ala Val Phe Gly Gly 
                85                  90                  95      


Gly Thr His Leu Thr Val Leu 
            100             


<210>  31
<211>  123
<212>  PRT
<213>  llama glama

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Gly Ile His Ile Ser Gly Gly Ile Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Pro Pro Gly Pro Phe Lys Ala His Tyr Asn Gly Met Lys Tyr 
            100                 105                 110         


Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  32
<211>  110
<212>  PRT
<213>  llama glama

<400>  32

Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Leu Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Gly Thr Ser Arg Asp Ile Gly Asp Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Leu Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Lys Val Asn Thr Arg Ser Ser Gly Thr Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Leu Tyr 
                85                  90                  95      


Ala Asp Tyr Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 
            100                 105                 110 


<210>  33
<211>  30
<212>  PRT
<213>  llama glama

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody fragment

<400>  34

Ser Tyr Asp Met Asn 
1               5   


<210>  35
<211>  14
<212>  PRT
<213>  llama glama

<400>  35

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  36

Ser Ile Tyr Asn Asp Ala Ser Asn Thr Ala Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  37

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  38

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  39
<211>  30
<212>  PRT
<213>  llama glama

<400>  39

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  40
<211>  14
<212>  PRT
<213>  llama glama

<400>  40

Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser 
1               5                   10                  


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  41

Gly Ile His Ile Ser Gly Gly Ile Thr Tyr Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  42

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Thr 
            20                  25                  30          


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  43

Pro Pro Gly Pro Phe Lys Ala His Tyr Asn Gly Ala Lys Tyr 
1               5                   10                  


<210>  44
<211>  11
<212>  PRT
<213>  llama glama

<400>  44

Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  45
<211>  22
<212>  PRT
<213>  llama glama

<400>  45

Leu Pro Val Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys 
            20          


<210>  46
<211>  15
<212>  PRT
<213>  llama glama

<400>  46

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
1               5                   10                  15  


<210>  47
<211>  7
<212>  PRT
<213>  llama glama

<400>  47

Gly Gln Asn Asn Arg Pro Ser 
1               5           


<210>  48
<211>  20
<212>  PRT
<213>  llama glama

<400>  48

Asn Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu Asp Glu Ala 
1               5                   10                  15      


Glu Tyr Tyr Cys 
            20  


<210>  49
<211>  10
<212>  PRT
<213>  llama glama

<400>  49

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  50
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  50

Ser Tyr Glu Leu Thr Gln Pro Ser Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys 
            20          


<210>  51
<211>  15
<212>  PRT
<213>  llama glama

<400>  51

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
1               5                   10                  15  


<210>  52
<211>  360
<212>  PRT
<213>  llama glama

<400>  52

Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Cys Gly Thr Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr 
            20                  25                  30          


Gly Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Thr 
        35                  40                  45              


Thr Cys Thr Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr 
    50                  55                  60                  


Gly Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Thr Thr 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Gly Thr Ala Gly Cys Thr Ala Cys 
                85                  90                  95      


Gly Ala Cys Ala Thr Gly Ala Gly Cys Thr Gly Gly Gly Thr Cys Cys 
            100                 105                 110         


Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala 
        115                 120                 125             


Gly Gly Gly Gly Cys Thr Gly Gly Ala Gly Thr Gly Gly Gly Thr Gly 
    130                 135                 140                 


Thr Cys Cys Ala Gly Thr Ala Thr Thr Thr Ala Thr Ala Ala Thr Gly 
145                 150                 155                 160 


Ala Cys Gly Gly Thr Ala Gly Thr Ala Ala Cys Ala Cys Ala Gly Cys 
                165                 170                 175     


Cys Thr Ala Thr Thr Cys Ala Gly Ala Cys Thr Cys Cys Gly Thr Gly 
            180                 185                 190         


Ala Ala Gly Gly Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Thr Cys Cys Ala Gly Ala Gly Ala Cys Ala Ala Cys Gly Cys 
    210                 215                 220                 


Cys Ala Ala Gly Ala Ala Cys Ala Cys Gly Thr Thr Gly Thr Ala Thr 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Thr 
                245                 250                 255     


Thr Gly Ala Ala Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Gly Gly Cys Cys Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Ala Ala Ala Ala Gly Thr Thr Gly Gly Cys Thr Thr Thr Ala 
    290                 295                 300                 


Gly Thr Gly Gly Thr Ala Cys Thr Thr Ala Cys Thr Ala Cys Ala Gly 
305                 310                 315                 320 


Thr Gly Ala Ala Thr Cys Ala Thr Gly Gly Gly Gly Cys Cys Ala Gly 
                325                 330                 335     


Gly Gly Gly Ala Cys Cys Cys Ala Gly Gly Thr Cys Ala Cys Cys Gly 
            340                 345                 350         


Thr Gly Thr Cys Cys Thr Cys Ala 
        355                 360 


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Seqence

<220>
<223>  Germlined antibody sequence

<400>  53

Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Glu Asp Glu Ala 
1               5                   10                  15      


Asp Tyr Tyr Cys 
            20  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  54

Gln Ser Gly Ser Ser Ser Ser Asn Ala Val 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  55

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  56
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  56

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys 
            20          


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  57

Thr Gly Thr Ser Ser Asp Ile Gly Ser Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  58

Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  59

Glu Val Asn Lys Arg Ser Ser 
1               5           


<210>  60
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  60

Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
1               5                   10                  15      


Asp Tyr Tyr Cys 
            20  


<210>  61
<211>  10
<212>  PRT
<213>  llama glama

<400>  61

Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
1               5                   10  


<210>  62
<211>  103
<212>  PRT
<213>  llama glama

<400>  62

Leu Pro Val Leu Thr Gln Pro Ser Ala Val Ser Val Ser Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gln Gly Gly Tyr Tyr Ala His Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Gln Asn Asn 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Gly Ala Gly Asn 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Glu Asp Glu Ala Glu 
65                  70                  75                  80  


Tyr Tyr Cys Gln Ser Gly Ser Ser Ser Ala Asn Ala Val Phe Gly Gly 
                85                  90                  95      


Gly Thr Lys Leu Thr Val Leu 
            100             


<210>  63
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Asn Asp Ala Ser Asn Thr Ala Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Phe Ser Gly Thr Tyr Tyr Ser Glu Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  64
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  64

Ser Tyr Glu Leu Thr Gln Pro Ser Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gln Gly Gly Tyr Tyr Ala His Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Gln Asn Asn 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Gly Ala Gly Asn 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Glu Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys Gln Ser Gly Ser Ser Ser Ser Asn Ala Val Phe Gly Gly 
                85                  90                  95      


Gly Thr Lys Leu Thr Val Leu 
            100             


<210>  65
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Gly Ile His Ile Ser Gly Gly Ile Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Pro Pro Gly Pro Phe Lys Ala His Tyr Asn Gly Ala Lys Tyr 
            100                 105                 110         


Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  66
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  66

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Val Asn Lys Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Leu Tyr 
                85                  90                  95      


Ala Asp Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  67
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Asn Asp Ala Ser Asn Thr Ala Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Gly Phe Ser Gly Thr Tyr Tyr Ser Glu Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  68
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  68

Ser Tyr Glu Leu Thr Gln Pro Ser Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gln Gly Gly Tyr Tyr Ala His Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Gln Asn Asn 
        35                  40                  45              


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Gly Ala Gly Asn 
    50                  55                  60                  


Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Glu Asp Glu Ala Asp 
65                  70                  75                  80  


Tyr Tyr Cys Gln Ser Gly Ser Ser Ser Ser Asn Ala Val Phe Gly Gly 
                85                  90                  95      


Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val 
            100                 105                 110         


Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr 
        115                 120                 125             


Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala 
    130                 135                 140                 


Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr 
145                 150                 155                 160 


Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser 
                165                 170                 175     


Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val 
            180                 185                 190         


Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys 
        195                 200                 205             


Ser 
    


<210>  69
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Gly Ile His Ile Ser Gly Gly Ile Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Pro Pro Gly Pro Phe Lys Ala His Tyr Asn Gly Ala Lys Tyr 
            100                 105                 110         


Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  70
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  70

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Val Asn Lys Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Leu Tyr 
                85                  90                  95      


Ala Asp Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  71
<211>  574
<212>  PRT
<213>  homo sapiens

<400>  71

Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala His 
1               5                   10                  15      


Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln Ser 
            20                  25                  30          


Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly Thr 
        35                  40                  45              


Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg Asp 
    50                  55                  60                  


Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys Asn 
65                  70                  75                  80  


Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg Val 
                85                  90                  95      


Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp Arg 
            100                 105                 110         


Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr Cys 
        115                 120                 125             


Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr 
    130                 135                 140                 


Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe 
145                 150                 155                 160 


His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln 
                165                 170                 175     


Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr 
            180                 185                 190         


Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp 
        195                 200                 205             


Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro Asp 
    210                 215                 220                 


Arg Thr Trp Thr Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met Gly 
225                 230                 235                 240 


Phe Leu Val Ala Val Leu Cys Tyr Leu Ser Tyr Arg Tyr Val Thr Lys 
                245                 250                 255     


Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln Arg Val Leu Thr Phe 
            260                 265                 270         


Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu Ile Pro Val Phe Asp 
        275                 280                 285             


Leu Ser Gly Pro Ser Ser Leu Ala Gln Pro Val Gln Tyr Ser Gln Ile 
    290                 295                 300                 


Arg Val Ser Gly Pro Arg Glu Pro Ala Gly Ala Pro Gln Arg His Ser 
305                 310                 315                 320 


Leu Ser Glu Ile Thr Tyr Leu Gly Gln Pro Asp Ile Ser Ile Leu Gln 
                325                 330                 335     


Pro Ser Asn Val Pro Pro Pro Gln Ile Leu Ser Pro Leu Ser Tyr Ala 
            340                 345                 350         


Pro Asn Ala Ala Pro Glu Val Gly Pro Pro Ser Tyr Ala Pro Gln Val 
        355                 360                 365             


Thr Pro Glu Ala Gln Phe Pro Phe Tyr Ala Pro Gln Ala Ile Ser Lys 
    370                 375                 380                 


Val Gln Pro Ser Ser Tyr Ala Pro Gln Ala Thr Pro Asp Ser Trp Pro 
385                 390                 395                 400 


Pro Ser Tyr Gly Val Cys Met Glu Gly Ser Gly Lys Asp Ser Pro Thr 
                405                 410                 415     


Gly Thr Leu Ser Ser Pro Lys His Leu Arg Pro Lys Gly Gln Leu Gln 
            420                 425                 430         


Lys Glu Pro Pro Ala Gly Ser Cys Met Leu Gly Gly Leu Ser Leu Gln 
        435                 440                 445             


Glu Val Thr Ser Leu Ala Met Glu Glu Ser Gln Glu Ala Lys Ser Leu 
    450                 455                 460                 


His Gln Pro Leu Gly Ile Cys Thr Asp Arg Thr Ser Asp Pro Asn Val 
465                 470                 475                 480 


Leu His Ser Gly Glu Glu Gly Thr Pro Gln Tyr Leu Lys Gly Gln Leu 
                485                 490                 495     


Pro Leu Leu Ser Ser Val Gln Ile Glu Gly His Pro Met Ser Leu Pro 
            500                 505                 510         


Leu Gln Pro Pro Ser Arg Pro Cys Ser Pro Ser Asp Gln Gly Pro Ser 
        515                 520                 525             


Pro Trp Gly Leu Leu Glu Ser Leu Val Cys Pro Lys Asp Glu Ala Lys 
    530                 535                 540                 


Ser Pro Ala Pro Glu Thr Ser Asp Leu Glu Gln Pro Thr Glu Leu Asp 
545                 550                 555                 560 


Ser Leu Phe Arg Gly Leu Ala Leu Thr Val Gln Trp Glu Ser 
                565                 570                 


<210>  72
<211>  1725
<212>  DNA
<213>  homo sapiens

<400>  72
atgaggacgc tgctgaccat cttgactgtg ggatccctgg ctgctcacgc ccctgaggac       60

ccctcggatc tgctccagca cgtgaaattc cagtccagca actttgaaaa catcctgacg      120

tgggacagcg ggccggaggg caccccagac acggtctaca gcatcgagta taagacgtac      180

ggagagaggg actgggtggc aaagaagggc tgtcagcgga tcacccggaa gtcctgcaac      240

ctgacggtgg agacgggcaa cctcacggag ctctactatg ccagggtcac cgctgtcagt      300

gcgggaggcc ggtcagccac caagatgact gacaggttca gctctctgca gcacactacc      360

ctcaagccac ctgatgtgac ctgtatctcc aaagtgagat cgattcagat gattgttcat      420

cctaccccca cgcccatccg tgcaggcgat ggccaccggc taaccctgga agacatcttc      480

catgacctgt tctaccactt agagctccag gtcaaccgca cctaccaaat gcaccttgga      540

gggaagcaga gagaatatga gttcttcggc ctgacccctg acacagagtt ccttggcacc      600

atcatgattt gcgttcccac ctgggccaag gagagtgccc cctacatgtg ccgagtgaag      660

acactgccag accggacatg gacctactcc ttctccggag ccttcctgtt ctccatgggc      720

ttcctcgtcg cagtactctg ctacctgagc tacagatatg tcaccaagcc gcctgcacct      780

cccaactccc tgaacgtcca gcgagtcctg actttccagc cgctgcgctt catccaggag      840

cacgtcctga tccctgtctt tgacctcagc ggccccagca gtctggccca gcctgtccag      900

tactcccaga tcagggtgtc tggacccagg gagcctgcag gagctccaca gcggcatagc      960

ctgtccgaga tcacctactt agggcagcca gacatctcca tcctccagcc ctccaacgtg     1020

ccacctcccc agatcctctc cccactgtcc tatgccccaa acgctgcccc tgaggtcggg     1080

cccccatcct atgcacctca ggtgaccccc gaagctcaat tcccattcta cgccccacag     1140

gccatctcta aggtccagcc ttcctcctat gcccctcaag ccactccgga cagctggcct     1200

ccctcctatg gggtatgcat ggaaggttct ggcaaagact cccccactgg gacactttct     1260

agtcctaaac accttaggcc taaaggtcag cttcagaaag agccaccagc tggaagctgc     1320

atgttaggtg gcctttctct gcaggaggtg acctccttgg ctatggagga atcccaagaa     1380

gcaaaatcat tgcaccagcc cctggggatt tgcacagaca gaacatctga cccaaatgtg     1440

ctacacagtg gggaggaagg gacaccacag tacctaaagg gccagctccc cctcctctcc     1500

tcagtccaga tcgagggcca ccccatgtcc ctccctttgc aacctccttc ccgtccatgt     1560

tccccctcgg accaaggtcc aagtccctgg ggcctgctgg agtcccttgt gtgtcccaag     1620

gatgaagcca agagcccagc ccctgagacc tcagacctgg agcagcccac agaactggat     1680

tctcttttca gaggcctggc cctgactgtg cagtgggagt cctga                     1725


<210>  73
<211>  309
<212>  DNA
<213>  llama glama

<400>  73
aattttatgc tgactcagcc ctccgcggtg tccgtgtctt tgggacagac ggccaagatc       60

acctgccaag ggggctatta tgctcactgg taccagcaga agccaggcca ggcccctgtg      120

ttggtcatct atggaaataa taataggccc tcagggatcc ctgagcgctt ctctggctcc      180

agttctggga acacagccac cctgaccatc agcggggccc aggctgagga cgaggccgag      240

tattactgtc agtcaggaag cagtagtgct aatgctgtgt tcggcggagg gacccatctg      300

accgtcctg                                                              309


<210>  74
<211>  369
<212>  DNA
<213>  llama glama

<400>  74
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggggattc tctgagactc       60

tcctgtgcag cctctggatt caccttcgga agctatttca tgagctgggt ccgccaggct      120

ccaggaaagg ggcccgagtg ggtctcaggt attcatatta gtggtggtat tacatactac      180

ttagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      240

ctgcaaatga acaacctgaa acctgaggac acggccgtgt attattgtgt aacacccccg      300

ggccccttta aggcccatta caatggcatg aagtactggg gcaaagggac cctggtcacc      360

gtctcctca                                                              369


<210>  75
<211>  330
<212>  DNA
<213>  llama glama

<400>  75
aattttatgc tgactcagcc tccctccgtg tctggaactc tgggaaagac ggtcaccatc       60

tcctgcactg gaaccagtcg tgacattggg gactataact atgtctcctg gtatcaacag      120

ctcccaggat tggcccccaa actcctgatc tataaagtca acactcgatc ctcagggacc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ccctgaccat ctctgggctc      240

cagtctgagg acgaggctga ttattactgt gcctcatata gactgtacgc cgattatgtg      300

ttcggcggag ggacccatct gaccgtcctg                                       330


<210>  76
<211>  360
<212>  DNA
<213>  llama glama

<400>  76
caggtgcagc tcgtggagtc tgggggaggc ttggtgcagc ctgggggttc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctacgaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtgtccagt atttataatg acggtagtaa cacagcctat      180

tcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgttgtat      240

ctgcaaatga acagcttgaa atctgaggac acggccgtgt attactgtgc aaaagttggc      300

tttagtggta cttactacag tgaatcatgg ggccagggga cccaggtcac cgtgtcctca      360


<210>  77
<211>  309
<212>  DNA
<213>  llama glama

<400>  77
ctgcctgtgc tgactcagcc ctccgcggtg tccgtgtctt tgggacagac ggccaggatc       60

acctgccaag ggggctatta tgctcactgg taccagcaga agccaggcca ggcccctgtg      120

ctggtcatct atggacagaa taataggccc tcagggatcc ctgagcgctt ctctggctcc      180

ggcgctggga acacagccac cctgaccatc agcggggccc aggctgagga cgaggctgag      240

tattactgtc agtcaggaag cagtagtgct aatgctgtgt tcggcggagg gaccaagctg      300

accgtcctc                                                              309


<210>  78
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  78
caggtgcagc tcgtggagtc tgggggaggc ttggtgcagc ctgggggttc tctgagactc       60

tcctgtgctg cctctggatt caccttcagt agctacgaca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtgtccagc atttataacg acgccagtaa cacagcctat      180

tcagactccg tgaagggccg attcaccatc tccagagaca actcaaagaa cacgttgtat      240

ctgcaaatga acagcctgag agctgaggac acggccgtgt attactgtgc gaaagttggc      300

tttagtggta cttactacag tgaatcatgg ggccagggga ccctcgtcac tgtctcctca      360


<210>  79
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  79
tcctacgaac tgactcagcc ctcctcggtg tccgtggcgt tgggacagac ggccaggatc       60

acctgccaag gaggctatta tgcacactgg taccagcaga agccaggcca ggcccctgtg      120

ctggtcatct atggacagaa taataggccc tcagggatcc ctgagcgctt ctctggctcc      180

ggcgctggga acacagccac cctgacaatc agccgcgccc aggctgagga cgaggctgac      240

tattactgtc agtcaggaag cagtagttct aatgctgtgt tcggcggagg gaccaagctg      300

accgtcctc                                                              309


<210>  80
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  80
caggtgcagc tcgtggagtc tgggggcggc ttggtgcagc ctggggattc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatttca tgagctgggt ccgccaggct      120

ccaggaaagg ggcccgagtg ggtctcaggt attcatatta gtggtggtat tacatactac      180

acggactccg tgaagggccg attcaccatc tccagagaca acgcaaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggccgtgt attattgtgt aacacccccg      300

ggccccttta aggcccatta caatggcgcg aagtactggg gcaaagggac cctggtcact      360

gtctcctca                                                              369


<210>  81
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Germlined antibody sequence

<400>  81
cagtctgccc tgactcagcc tccctccgtg tctggatctc ctggacagtc tgtcaccatc       60

tcctgcactg gaaccagtag tgacattggg tcctataact atgtctcctg gtatcaacag      120

ctcccaggaa aggcccccaa actcctgatc tatgaggtca acaagcgatc ctcaggggtc      180

cctgatcgct tctctggctc caagtcaggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgt gcctcatata gactgtacgc cgattatgtg      300

ttcggcggag ggacccaact gaccgtcctc                                       330


<210>  82
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  82

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  83
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  83

Cys Pro Pro Cys Pro 
1               5   


<210>  84
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  84

Ala Pro Glu Leu Leu Gly Gly Pro 
1               5               


<210>  85
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  85

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  86
<211>  50
<212>  PRT
<213>  homo sapiens

<400>  86

Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
1               5                   10                  15      


Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            20                  25                  30          


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        35                  40                  45              


Cys Pro 
    50  


<210>  87
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  87

Ala Pro Glu Leu Leu Gly Gly Pro 
1               5               


<210>  88
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  88

Glu Ser Lys Tyr Gly Pro Pro 
1               5           


<210>  89
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  89

Cys Pro Ser Cys Pro 
1               5   


<210>  90
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  90

Ala Pro Glu Phe Leu Gly Gly Pro 
1               5               


<210>  91
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  91

Glu Arg Lys 
1           


<210>  92
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  92

Cys Cys Val Glu Cys Pro Pro Pro Cys Pro 
1               5                   10  


<210>  93
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  93

Ala Pro Pro Val Ala Gly Pro 
1               5           


<210>  94
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EST sequence

<400>  94

Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr Pro Ile Arg 
1               5                   10                  15      


Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe His Asp Leu 
            20                  25                  30          


Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln Met His Leu 
        35                  40                  45              


Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr Pro Asp Thr 
    50                  55                  60                  


Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp Ala 
65                  70                  75              


<210>  95
<211>  78
<212>  PRT
<213>  macaca mulatta

<400>  95

Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr Pro Ile Arg 
1               5                   10                  15      


Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe His Asp Leu 
            20                  25                  30          


Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln Met His Leu 
        35                  40                  45              


Gly Gly Glu Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr Pro Asp Thr 
    50                  55                  60                  


Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp Ser 
65                  70                  75              


<210>  96
<211>  79
<212>  PRT
<213>  macaca fascicularis

<400>  96

Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr Pro Ile Arg 
1               5                   10                  15      


Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Tyr Asp Leu Ser 
            20                  25                  30          


Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln Met Val Asn His 
        35                  40                  45              


Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr Pro Asp 
    50                  55                  60                  


Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp Ser 
65                  70                  75                  


<210>  97
<211>  79
<212>  PRT
<213>  macaca fascicularis

<400>  97

Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr Pro Ile Arg 
1               5                   10                  15      


Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Tyr Asp Leu Ser 
            20                  25                  30          


Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln Met Val Asn His 
        35                  40                  45              


Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr Pro Asp 
    50                  55                  60                  


Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp Ser 
65                  70                  75                  


<210>  98
<211>  77
<212>  PRT
<213>  macaca fascicularis

<400>  98

Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr Pro Ile Arg 
1               5                   10                  15      


Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Tyr Asp Leu Ser 
            20                  25                  30          


Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln Met His Leu Gly 
        35                  40                  45              


Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr Pro Asp Thr Glu 
    50                  55                  60                  


Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp Ser 
65                  70                  75          


<210>  99
<211>  293
<212>  PRT
<213>  homo sapiens

<400>  99

Leu Arg Leu Glu Tyr Leu Ile Arg Leu Thr Ile Gly Tyr Arg Leu Asn 
1               5                   10                  15      


Gly Thr Ala Ala Thr Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val 
            20                  25                  30          


Ala Thr Ala Thr Gly Val His Ser Pro Glu Asp Pro Ser Asp Leu Leu 
        35                  40                  45              


Gln His Val Lys Phe Gln Ser Ser Asn Phe Glu Asn Ile Leu Thr Trp 
    50                  55                  60                  


Asp Ser Gly Pro Glu Gly Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr 
65                  70                  75                  80  


Lys Thr Tyr Gly Glu Arg Asp Trp Val Ala Lys Lys Gly Cys Gln Arg 
                85                  90                  95      


Ile Thr Arg Lys Ser Cys Asn Leu Thr Val Glu Thr Gly Asn Leu Thr 
            100                 105                 110         


Glu Leu Tyr Tyr Ala Arg Val Thr Ala Val Ser Ala Gly Gly Arg Ser 
        115                 120                 125             


Ala Thr Lys Met Thr Asp Arg Phe Ser Ser Leu Gln His Thr Thr Leu 
    130                 135                 140                 


Lys Pro Pro Asp Val Thr Cys Ile Ser Lys Val Arg Ser Ile Gln Met 
145                 150                 155                 160 


Ile Val His Pro Thr Pro Thr Pro Ile Arg Ala Gly Asp Gly His Arg 
                165                 170                 175     


Leu Thr Leu Glu Asp Ile Phe His Asp Leu Phe Tyr His Leu Glu Leu 
            180                 185                 190         


Gln Val Asn Arg Thr Tyr Gln Met His Leu Gly Gly Lys Gln Arg Glu 
        195                 200                 205             


Tyr Glu Phe Phe Gly Leu Thr Pro Asp Thr Glu Phe Leu Gly Thr Ile 
    210                 215                 220                 


Met Ile Cys Val Pro Thr Trp Ala Lys Glu Ser Ala Pro Tyr Met Cys 
225                 230                 235                 240 


Arg Val Lys Thr Leu Pro Asp Arg Thr Trp Thr Ile Glu Gly Arg Asp 
                245                 250                 255     


Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Leu Leu Gly Arg Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu 
    290             


<210>  100
<211>  293
<212>  PRT
<213>  macaca mulatta

<400>  100

Leu Arg Leu Glu Tyr Leu Ile Arg Leu Thr Ile Gly Tyr Arg Leu Asn 
1               5                   10                  15      


Gly Thr Ala Ala Thr Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val 
            20                  25                  30          


Ala Thr Ala Thr Gly Val His Ser Pro Glu Asp Pro Ser Asp Leu Leu 
        35                  40                  45              


Gln His Val Lys Phe Gln Ser Asn Asn Phe Glu Asn Ile Leu Thr Trp 
    50                  55                  60                  


Asp Ser Gly Pro Glu Gly Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr 
65                  70                  75                  80  


Lys Thr Tyr Gly Glu Arg Asp Trp Val Ala Lys Lys Gly Cys Gln Arg 
                85                  90                  95      


Ile Thr Arg Lys Ser Cys Asn Leu Thr Val Glu Thr Gly Asn His Thr 
            100                 105                 110         


Glu Leu Tyr Tyr Ala Arg Val Thr Ala Val Ser Ala Gly Gly Arg Ser 
        115                 120                 125             


Ala Thr Lys Met Thr Asp Arg Phe Asn Ser Leu Gln His Thr Ala Leu 
    130                 135                 140                 


Lys Pro Pro Asp Val Thr Cys Ile Pro Lys Val Arg Ser Ile Gln Met 
145                 150                 155                 160 


Ile Val His Pro Thr Pro Thr Pro Ile Arg Ala Gly Asp Gly His Arg 
                165                 170                 175     


Leu Thr Leu Glu Asp Ile Phe His Asp Leu Phe Tyr His Leu Glu Leu 
            180                 185                 190         


Gln Val Asn Arg Thr Tyr Gln Met His Leu Gly Gly Glu Gln Arg Glu 
        195                 200                 205             


Tyr Glu Phe Phe Gly Leu Thr Pro Asp Thr Glu Phe Leu Gly Thr Ile 
    210                 215                 220                 


Met Ile Cys Val Pro Thr Trp Ser Lys Lys Ser Ala Pro Tyr Met Cys 
225                 230                 235                 240 


Arg Val Arg Thr Leu Pro Asp Arg Thr Trp Thr Ile Glu Gly Arg Asp 
                245                 250                 255     


Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            260                 265                 270         


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        275                 280                 285             


Pro Lys Asp Thr Leu 
    290             


<210>  101
<211>  292
<212>  PRT
<213>  macaca fascicularis

<400>  101

Leu Arg Leu Glu Tyr Leu Ile Arg Leu Thr Ile Gly Tyr Arg Leu Asn 
1               5                   10                  15      


Gly Thr Ala Ala Thr Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val 
            20                  25                  30          


Ala Thr Ala Thr Gly Val His Ser Pro Glu Asp Pro Ser Asp Leu Leu 
        35                  40                  45              


Gln His Val Lys Phe Gln Ser Asn Asn Phe Glu Asn Ile Leu Thr Trp 
    50                  55                  60                  


Asp Ser Gly Pro Glu Gly Thr Pro Asp Thr Val Tyr Ser Ile Glu Tyr 
65                  70                  75                  80  


Lys Thr Tyr Gly Glu Arg Asp Trp Val Ala Lys Lys Gly Cys Gln Arg 
                85                  90                  95      


Ile Thr Arg Lys Ser Cys Asn Leu Thr Val Glu Thr Gly Asn His Thr 
            100                 105                 110         


Glu Leu Tyr Tyr Ala Arg Val Thr Ala Val Ser Ala Gly Gly Arg Ser 
        115                 120                 125             


Ala Thr Lys Met Thr Asp Arg Phe Asn Ser Leu Gln His Thr Ala Leu 
    130                 135                 140                 


Lys Pro Pro Asp Val Thr Cys Ile Pro Lys Val Arg Ser Ile Gln Met 
145                 150                 155                 160 


Ile Val His Pro Thr Pro Thr Pro Ile Arg Ala Gly Asp Gly His Arg 
                165                 170                 175     


Leu Thr Leu Glu Asp Ile Tyr Asp Leu Ser Tyr His Leu Glu Leu Gln 
            180                 185                 190         


Val Asn Arg Thr Tyr Gln Met His Leu Gly Gly Lys Gln Arg Glu Tyr 
        195                 200                 205             


Glu Phe Phe Gly Leu Thr Pro Asp Thr Glu Phe Leu Gly Thr Ile Met 
    210                 215                 220                 


Ile Cys Val Pro Thr Trp Ser Lys Lys Ser Ala Pro Tyr Met Cys Arg 
225                 230                 235                 240 


Val Arg Thr Leu Pro Asp Arg Thr Trp Thr Ile Glu Gly Arg Asp Met 
                245                 250                 255     


Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu 
    290         


