                         SEQUENCE LISTING

<110>  IOVANCE BIOTHERAPEUTICS
       Rabinovich, Brian
       Martin-Orozco, Natalia
       Radvanyi, Laszlo
 
<120>  PROGRAMMED DEATH 1 LIGAND 1 (PD-L1) BINDING PROTEINS AND METHODS 
       OF USE THEREOF

<130>  116983-5024-WO

<150>  US 62/359,612
<151>  2016-07-07

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  1

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Arg Lys Ile Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Thr Asp Arg Pro Ala Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Met Ala Thr Leu Thr Ile Ser Thr Val Gly Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  2

Asn Ile Gly Arg Lys Ile 
1               5       


<210>  3
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  3

Tyr Asp Thr 
1           


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4

Gln Val Trp Asp Thr Gly Ser Asp His Val Val 
1               5                   10      


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ala 
        115                 120         


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  6

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  7

Ile Ser Gly Ser Gly Gly Thr Thr 
1               5               


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  8

Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  9
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Leu Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Arg Lys 
            20                  25                  30          


Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asn Asn Gln Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Gly Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10

Ser Gly Ser Ile Ala Arg Lys Phe 
1               5               


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  11

Glu Asn Asn 
1           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  12

Gln Ser Tyr Asp Ser Ser Asn Val Val 
1               5                   


<210>  13
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Thr Ala Gly Asp Thr His Tyr Pro Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Asn Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Glu Arg Val Glu Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala 
        115                 120             


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  14

Gly Phe Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  15

Ile Asn Thr Ala Gly Asp Thr 
1               5           


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  16

Val Arg Glu Arg Val Glu Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  17
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Pro Ser Tyr Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
145                 150                 155                 160 


Thr Cys Gly Gly Asn Asn Ile Gly Arg Lys Ile Val His Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Tyr Asp Thr Asp 
            180                 185                 190         


Arg Pro Ala Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
        195                 200                 205             


Met Ala Thr Leu Thr Ile Ser Thr Val Gly Ala Gly Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp His Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  18
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  18

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Ser Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp Ala Phe 
        115                 120                 125             


Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Pro Ser 
145                 150                 155                 160 


Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr 
                165                 170                 175     


Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Arg Lys Ile Val His 
            180                 185                 190         


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Tyr 
        195                 200                 205             


Asp Thr Asp Arg Pro Ala Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn 
    210                 215                 220                 


Ser Gly Asn Met Ala Thr Leu Thr Ile Ser Thr Val Gly Ala Gly Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp His Val 
                245                 250                 255     


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Pro Arg Ala Asn 
            260                 265                 270         


Phe Val Tyr Lys Ser Gly Pro Arg Pro Lys Ser Cys Asp Lys Thr His 
        275                 280                 285             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    290                 295                 300                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
305                 310                 315                 320 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                325                 330                 335     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            340                 345                 350         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        355                 360                 365             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    370                 375                 380                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
385                 390                 395                 400 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                405                 410                 415     


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            420                 425                 430         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        435                 440                 445             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    450                 455                 460                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
465                 470                 475                 480 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                485                 490                 495     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505                 510     


<210>  19
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Thr Ala Gly Asp Thr His Tyr Pro Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Asn Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Glu Arg Val Glu Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Pro Asn Phe Met 
    130                 135                 140                 


Leu Thr Gln Pro His Ser Val Ser Glu Ser Leu Gly Lys Thr Val Thr 
145                 150                 155                 160 


Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Arg Lys Phe Val Gln 
                165                 170                 175     


Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu 
            180                 185                 190         


Asn Asn Gln Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Ile 
        195                 200                 205             


Gly Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Val 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250     


<210>  20
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  20

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Ser Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Asn Thr Ala Gly Asp Thr His Tyr Pro Glu 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser 
                85                  90                  95      


Leu Asn Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Val Arg Glu Arg Val Glu Arg Glu Tyr Ser Gly Tyr Asp Ala 
        115                 120                 125             


Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Pro 
145                 150                 155                 160 


Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Leu Gly Lys 
                165                 170                 175     


Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Arg Lys 
            180                 185                 190         


Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        195                 200                 205             


Ile Tyr Glu Asn Asn Gln Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Ile Gly Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
225                 230                 235                 240 


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                245                 250                 255     


Ser Asn Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Pro 
            260                 265                 270         


Arg Ala Asn Phe Val Tyr Lys Ser Gly Pro Arg Pro Lys Ser Cys Asp 
        275                 280                 285             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    290                 295                 300                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
305                 310                 315                 320 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                325                 330                 335     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            340                 345                 350         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        355                 360                 365             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    370                 375                 380                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
385                 390                 395                 400 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                405                 410                 415     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            420                 425                 430         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        435                 440                 445             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    450                 455                 460                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
465                 470                 475                 480 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                485                 490                 495     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            500                 505                 510         


Gly Lys 
        


<210>  21
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  21

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  22
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  22

Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Glu Thr Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Gln Glu Glu Met Glu Thr Thr Lys Asn Gln Val Ser Leu 
    130                 135                 140                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
145                 150                 155                 160 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                165                 170                 175     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            180                 185                 190         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met Glu 
        195                 200                 205             


Thr His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  23
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  23

Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Glu Thr Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Gln Glu Glu Met Glu Thr Thr Lys Asn Gln Val Ser Leu 
    130                 135                 140                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
145                 150                 155                 160 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                165                 170                 175     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            180                 185                 190         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met Glu 
        195                 200                 205             


Thr His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  24
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  24

Arg Ser Gly Ser Ser Arg Met Glu Thr Lys Gln Ile Glu Asp Lys Ile 
1               5                   10                  15      


Glu Glu Ile Leu Ser Lys Ile Tyr His Ile Glu Asn Glu Ile Ala Arg 
            20                  25                  30          


Ile Lys Lys Leu Ile Gly Glu Arg Gly Thr Ser Ser Arg Gly 
        35                  40                  45      


<210>  25
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  25

Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser 
1               5                   10                  15      


Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu 
            20                  25                  30          


Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe 
        35                  40                  45              


Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro 
    50                  55                  60                  


Lys Leu Gln Met Glu Thr Gly Lys Lys Leu Pro Leu His Leu Thr Leu 
65                  70                  75                  80  


Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala 
                85                  90                  95      


Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val 
            100                 105                 110         


Met Glu Thr Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu Val 
        115                 120                 125             


Trp Gly Pro Thr Ser Pro Lys Leu Met Glu Thr Leu Ser Leu Lys Leu 
    130                 135                 140                 


Glu Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val 
145                 150                 155                 160 


Leu Asn Pro Glu Ala Gly Met Glu Thr Trp Gln Cys Leu Leu Ser Asp 
                165                 170                 175     


Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu 
            180                 185                 


<210>  26
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  26

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  27
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Val Cys Gly Gly Thr Thr Gly Ser Ser Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  28
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  28

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Ala Asp Thr Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  29
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  29

Met Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  30
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  30

Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
1               5                   10                  15      


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        35                  40                  45              


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
65                  70                  75                  80  


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile 
        115                 120                 125             


Ser Thr Leu Thr 
    130         


<210>  31
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  31

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser 
    130 


<210>  32
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  32

Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val 
1               5                   10                  15      


Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly 
            20                  25                  30          


Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys 
        35                  40                  45              


Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu 
    50                  55                  60                  


Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu 
65                  70                  75                  80  


Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln 
                85                  90                  95      


Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys 
            100                 105                 110         


Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp 
        115                 120                 125             


Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn 
    130                 135                 140                 


Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150             


<210>  33
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  33

Met Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
1               5                   10                  15      


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
            20                  25                  30          


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
        35                  40                  45              


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
    50                  55                  60                  


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
65                  70                  75                  80  


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                85                  90                  95      


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
            100                 105                 110         


Asn Thr Ser 
        115 


<210>  34
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  34

Met Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val 
1               5                   10                  15      


Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro 
            20                  25                  30          


Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys 
        35                  40                  45              


Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg 
    50                  55                  60                  


Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr 
65                  70                  75                  80  


Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp 
                85                  90                  95      


Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser 
            100                 105                 110         


Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly 
        115                 120                 125             


Ser Glu Asp Ser 
    130         


<210>  35
<211>  8449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLV430G (Lentiviral Vector)

<400>  35
cgataaccct aattcgatag catatgcttc ccgttgggta acatatgcta ttgaattagg       60

gttagtctgg atagtatata ctactacccg ggaagcatat gctacccgtt tagggttcac      120

cggtgatgcc ggccacgatg cgtccggcgt agaggatcta atgtgagtta gctcactcat      180

taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc      240

ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg cgcaattaac      300

cctcactaaa gggaacaaaa gctggagctg caagcttaat gtagtcttat gcaatactct      360

tgtagtcttg caacatggta acgatgagtt agcaacatgc cttacaagga gagaaaaagc      420

accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac      480

agacgggtct gacatggatt ggacgaacca ctgaattgcc gcattgcaga gatattgtat      540

ttaagtgcct agctcgatac ataaacgggt ctctctggtt agaccagatc tgagcctggg      600

agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc      660

ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct      720

tttagtcagt gtggaaaatc tctagcagtg gcgcccgaac agggacttga aagcgaaagg      780

gaaaccagag gagctctctc gacgcaggac tcggcttgct gaagcgcgca cggcaagagg      840

cgaggggcgg cgactggtga gtacgccaaa aattttgact agcggaggct agaaggagag      900

agatgggtgc gagagcgtca gtattaagcg ggggagaatt agatcgcgat gggaaaaaat      960

tcggttaagg ccagggggaa agaaaaaata taaattaaaa catatagtat gggcaagcag     1020

ggagctagaa cgattcgcag ttaatcctgg cctgttagaa acatcagaag gctgtagaca     1080

aatactggga cagctacaac catcccttca gacaggatca gaagaactta gatcattata     1140

taatacagta gcaaccctct attgtgtgca tcaaaggata gagataaaag acaccaagga     1200

agctttagac aagatagagg aagagcaaaa caaaagtaag accaccgcac agcaagcggc     1260

cgctgatctt cagacctgga ggaggagata tgagggacaa ttggagaagt gaattatata     1320

aatataaagt agtaaaaatt gaaccattag gagtagcacc caccaaggca aagagaagag     1380

tggtgcagag agaaaaaaga gcagtgggaa taggagcttt gttccttggg ttcttgggag     1440

cagcaggaag cactatgggc gcagcgtcaa tgacgctgac ggtacaggcc agacaattat     1500

tgtctggtat agtgcagcag cagaacaatt tgctgagggc tattgaggcg caacagcatc     1560

tgttgcaact cacagtctgg ggcatcaagc agctccaggc aagaatcctg gctgtggaaa     1620

gatacctaaa ggatcaacag ctcctgggga tttggggttg ctctggaaaa ctcatttgca     1680

ccactgctgt gccttggaat gctagttgga gtaataaatc tctggaacag atttggaatc     1740

acacgacctg gatggagtgg gacagagaaa ttaacaatta cacaagctta atacactcct     1800

taattgaaga atcgcaaaac cagcaagaaa agaatgaaca agaattattg gaattagata     1860

aatgggcaag tttgtggaat tggtttaaca taacaaattg gctgtggtat ataaaattat     1920

tcataatgat agtaggaggc ttggtaggtt taagaatagt ttttgctgta ctttctatag     1980

tgaatagagt taggcaggga tattcaccat tatcgtttca gacccacctc ccaaccccga     2040

ggggacccga caggcccgaa ggaatagaag aagaaggtgg agagagagac agagacagat     2100

ccattcgatt agtgaacgga tctcgacggt atcggtttta aaagaaaagg ggggattggg     2160

gggtacagtg caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa     2220

ttacaaaaac aaattacaaa aattcaaaat tttatcgatt ttatttagtc tccagaaaaa     2280

ggggggaatg aaagacccca cctgtaggtt tggcaagcta gcttaagtaa cgccattttg     2340

caaggcatgg aaaatacata actgagaata gagaagttca gatcaaggtt aggaacagag     2400

agacagcaga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag     2460

ggccaagaac agatggtccc cagatgcggt cccgccctca gcagtttcta gagaaccatc     2520

agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca     2580

atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc     2640

cacaacccct cactcggcgc gccagtcctc cgatagactg cgtcgcccgg gtaccgatat     2700

cacaagtttg tacaaaaaag ctgaacgaga aacgtaaaat gatataaata tcaatatatt     2760

aaattagatt ttgcataaaa aacagactac ataatactgt aaaacacaac atatccagtc     2820

actatggcgg ccgcattagg caccccaggc tttacacttt atgcttccgg ctcgtataat     2880

gtgtggattt tgagttagga tccgtcgaga ttttcaggag ctaaggaagc taaaatggag     2940

aaaaaaatca ctggatatac caccgttgat atatcccaat ggcatcgtaa agaacatttt     3000

gaggcatttc agtcagttgc tcaatgtacc tataaccaga ccgttcagct ggatattacg     3060

gcctttttaa agaccgtaaa gaaaaataag cacaagtttt atccggcctt tattcacatt     3120

cttgcccgcc tgatgaatgc tcatccggaa ttccgtatgg caatgaaaga cggtgagctg     3180

gtgatatggg atagtgttca cccttgttac accgttttcc atgagcaaac tgaaacgttt     3240

tcatcgctct ggagtgaata ccacgacgat ttccggcagt ttctacacat atattcgcaa     3300

gatgtggcgt gttacggtga aaacctggcc tatttcccta aagggtttat tgagaatatg     3360

tttttcgtct cagccaatcc ctgggtgagt ttcaccagtt ttgatttaaa cgtggccaat     3420

atggacaact tcttcgcccc cgttttcacc atgggcaaat attatacgca aggcgacaag     3480

gtgctgatgc cgctggcgat tcaggttcat catgccgttt gtgatggctt ccatgtcggc     3540

agaatgctta atgaattaca acagtactgc gatgagtggc agggcggggc gtaaacgcgt     3600

ggatccggct tactaaaagc cagataacag tatgcgtatt tgcgcgctga tttttgcggt     3660

ataagaatat atactgatat gtatacccga agtatgtcaa aaagaggtat gctatgaagc     3720

agcgtattac agtgacagtt gacagcgaca gctatcagtt gctcaaggca tatatgatgt     3780

caatatctcc ggtctggtaa gcacaaccat gcagaatgaa gcccgtcgtc tgcgtgccga     3840

acgctggaaa gcggaaaatc aggaagggat ggctgaggtc gcccggttta ttgaaatgaa     3900

cggctctttt gctgacgaga acaggggctg gtgaaatgca gtttaaggtt tacacctata     3960

aaagagagag ccgttatcgt ctgtttgtgg atgtacagag tgatattatt gacacgcccg     4020

ggcgacggat ggtgatcccc ctggccagtg cacgtctgct gtcagataaa gtctcccgtg     4080

aactttaccc ggtggtgcat atcggggatg aaagctggcg catgatgacc accgatatgg     4140

ccagtgtgcc ggtctccgtt atcggggaag aagtggctga tctcagccac cgcgaaaatg     4200

acatcaaaaa cgccattaac ctgatgttct ggggaatata aatgtcaggc tcccttatac     4260

acagccagtc tgcaggtcga ccatagtgac tggatatgtt gtgttttaca gtattatgta     4320

gtctgttttt tatgcaaaat ctaatttaat atattgatat ttatatcatt ttacgtttct     4380

cgttcagctt tcttgtacaa agtggtgatt cgagttaatt aagctagcct agtgccattt     4440

gttcagtggt tcgtagggct ttcccccact gtttggcttt cagttatatg gatgatgtgg     4500

tattgggggc caagtctgta cagcatcttg agtccctttt taccgctgtt accaattttc     4560

ttttgtcttt gggtatacat ttaaacccta acaaaacaaa gagatggggt tactctctaa     4620

attttatggg ttatgtcatt ggatgttatg ggtccttgcc acaagaacac atcatacaaa     4680

aaatcaaaga atgttttaga aaacttccta ttaacaggcc tattgattgg aaagtatgtc     4740

aacgaattgt gggtcttttg ggttttgctg ccccttttac acaatgtggt tatcctgcgt     4800

tgatgccttt gtatgcatgt attcaatcta agcaggcttt cactttctcg ccaacttaca     4860

aggcctttct gtgtaaacaa tacctgaacc tttaccccgt tgcccggcaa cggccaggtc     4920

tgtgccaagt gtttgctgac gcaaccccca ctggctgggg cttggtcatg ggccatcagc     4980

gcatgcgtgg aaccttttcg gctcctctgc cgatccatac tgcggaactc ctagccgctt     5040

gttttgctcg cagcaggtct ggagcaaaca ttatcgggac tgataactct gttgtcctat     5100

cccgcaaata tacatcgttt ccatggctgc taggctgtgc tgccaactgg atcctgcgcg     5160

ggacgtcctt tgtttacgtc ccgtcggcgc tgaatcctgc ggacgaccct tctcggggtc     5220

gcttgggact ctctcgtccc cttctccgtc tgccgttccg accgaccacg gggcgcacct     5280

ctctttacgc ggactccccg tctgtgcctt ctcatctgcc ggaccgtgtg cacttcgctt     5340

cacctctgca cgtcgcatgg agaccaccgt gaacgcccac caaatattgc ccaaggtctt     5400

acataagagg actcttggac tctcagcaat gtcaacgacc gaccttgagg catacttcaa     5460

agactgtttg tttaaagact gggaggagtt gggggaggag attaggttaa aggtctttgt     5520

actaggaggc tgtaggcata aattggtctg cgcaccagca ccatggcgca atcactagag     5580

cggggtacct ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa     5640

agaaaagggg ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc     5700

ttgtactggg tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg     5760

gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg     5820

tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat     5880

ctctagcagt agtagttcat gtcatcttat tattcagtat ttataacttg caaagaaatg     5940

aatatcagag agtgagagga acttgtttat tgcagcttat aatggttaca aataaagcaa     6000

tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc     6060

caaactcatc aatgtatctt atcatgtctg gctctagcta tcccgcccct aactccgccc     6120

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt     6180

tttatttatg cagaggccga ggccggatcc cttgagtggc tttcatcctg gagcagactt     6240

tgcagtctgt ggactgcaac acaacattgc ctttatgtgt aactcttggc tgaagctctt     6300

acaccaatgc tgggggacat gtacctccca ggggcccagg aagactacgg gaggctacac     6360

caacgtcaat cagaggggcc tgtgtagcta ccgataagcg gaccctcaag agggcattag     6420

caatagtgtt tataaggccc ccttgttaat tcttgaagac gaaagggcct cgtgatacgc     6480

ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt     6540

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat     6600

ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg     6660

agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt     6720

tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga     6780

gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa     6840

gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt     6900

gttgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt     6960

gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc     7020

agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga     7080

ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat     7140

cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct     7200

gcagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc     7260

cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg     7320

gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc     7380

ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg     7440

acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca     7500

ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta     7560

aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc     7620

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     7680

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     7740

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     7800

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     7860

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     7920

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     7980

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     8040

cgaacgacct acaccgaact gagataccta cagcgtgagc attgagaaag cgccacgctt     8100

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     8160

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     8220

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     8280

gccagcaacg cggccttttt acggttcctg gccttttgct ggcctttttg aagctgtccc     8340

tgatggtcgt catctacctg cctggacagc atggcctgca acgcgggcat cccgatgccg     8400

ccggaagcga gaagaatcat aatggggaag gccatccagc ctcgcgtcg                 8449


<210>  36
<211>  7298
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCIGO-VSV.G (VSVG)

<400>  36
gtcgacggat cgggagatca attccggcac ctgtcctacg agttgcatga taaagaagac       60

agtcataagt gcggcgacga tagtcatgcc ccgcgcccac cggaaggagc tgactgggtt      120

gaaggctctc aagggcatcg gtcgatgcag gaaaaggaca agcagcgaaa attcacgccc      180

ccttgggagg tggcggcata tgcaaaggat agcactccca ctctactact gggtatcata      240

tgctgactgt atatgcatga ggatagcata tgctacccgg atacagatta ggatagcata      300

tactacccag atatagatta ggatagcata tgctacccag atatagatta ggatagccta      360

tgctacccag atataaatta ggatagcata tactacccag atatagatta ggatagcata      420

tgctacccag atatagatta ggatagccta tgctacccag atatagatta ggatagcata      480

tgctacccag atatagatta ggatagcata tgctatccag atatttgggt agtatatgct      540

acccagatat aaattaggat agcatatact accctaatct ctattaggat agcatatgct      600

acccggatac agattaggat agcatatact acccagatat agattaggat agcatatgct      660

acccagatat agattaggat agcctatgct acccagatat aaattaggat agcatatact      720

acccagatat agattaggat agcatatgct acccagatat agattaggat agcctatgct      780

acccagatat agattaggat agcatatgct atccagatat ttgggtagta tatgctaccc      840

atggcaacat tagcccaccg tgctctcagc gacctcgtga atatgaggac caacaaccct      900

gtgcttggcg ctcaggcgca agtgtgtgta atttgtcctc cagatcgcag caatcgcgcc      960

cctatcttgg cccgcccacc tacttatgca ggtattcccc ggggtgccat tagtggtttt     1020

gtgggcaagt ggtttgaccg cagtggttag cggggttaca atcagccaag ttattacacc     1080

cttattttac agtccaaaac cgcagggcgg cgtgtggggg ctgacgcgtg cccccactcc     1140

acaatttcaa aaaaaagagt ggccacttgt ctttgtttat gggccccatt ggcgtggagc     1200

cccgtttaat tttcgggggt gttagagaca accagtggag tccgctgctg tcggcgtcca     1260

ctctctttcc ccttgttaca aatagagtgt aacaacatgg ttcacctgtc ttggtccctg     1320

cctgggacac atcttaataa ccccagtatc atattgcact aggattatgt gttgcccata     1380

gccataaatt cgtgtgagat ggacatccag tctttacggc ttgtccccac cccatggatt     1440

tctattgtta aagatattca gaatgtttca ttcctacact agtatttatt gcccaagggg     1500

tttgtgaggg ttatattggt gtcatagcac aatgccacca ctgaaccccc cgtccaaatt     1560

ttattctggg ggcgtcacct gaaaccttgt tttcgagcac ctcacataca ccttactgtt     1620

cacaactcag cagttattct attagctaaa cgaaggagaa tgaagaagca ggcgaagatt     1680

caggagagtt cactgcccgc tccttgatct tcagccactg cccttgtgac taaaatggtt     1740

cactaccctc gtggaatcct gaccccatgt aaataaaacc gtgacagctc atggggtggg     1800

agatatcgct gttccttagg acccttttac taaccctaat tcgatagcat atgcttcccg     1860

ttgggtaaca tatgctattg aattagggtt agtctggata gtatatacta ctacccggga     1920

agcatatgct acccgtttag ggttaacaag ggggccttat aaacactatt gctaatgccc     1980

tcttgagggt ccgcttatcg gtagctacac aggcccctct gattgacgtt ggtgtagcct     2040

cccgtagtct tcctgggccc ctgggaggta catgtccccc agcattggtg taagagcttc     2100

agccaagagt tacacataaa ggcaatgttg tgttgcagtc cacagactgc aaagtctgct     2160

ccaggatgaa agccactcaa gggatcttca atattggcca ttagccatat tattcattgg     2220

ttatatagca taaatcaata ttggctattg gccattgcat acgttgtatc tatatcataa     2280

tatgtacatt tatattggct catgtccaat atgaccgcca tgttggcatt gattattgac     2340

tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg     2400

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt     2460

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca     2520

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc     2580

aagtccgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta     2640

catgacctta cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac     2700

catggtgatg cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg     2760

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg     2820

ggactttcca aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt     2880

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatca ctagaagctt     2940

tattgcggta gtttatcaca gttaaattgc taacgcagtc agtgcttctg acacaacagt     3000

ctcgaactta agctgcagaa gttggtcgtg aggcactggg caggtaagta tcaaggttac     3060

aagacaggtt taaggagacc aatagaaact gggcttgtcg agacagagaa gactcttgcg     3120

tttctgatag gcacctattg gtcttactga catccacttt gcctttctct ccacaggtgt     3180

ccactcccag ttcaattaca gctcttaagg ctagagtact taatacgact cactataggc     3240

tagcggtacc gagctcggat ccactagtaa cggccgccag tgtgctggaa ttcaacagag     3300

atcgatctgt ttccttgaca ctatgaagtg ccttttgtac ttagcctttt tattcattgg     3360

ggtgaattgc aagttcacca tagtttttcc acacaaccaa aaaggaaact ggaaaaatgt     3420

tccttctaat taccattatt gcccgtcaag ctcagattta aattggcata atgacttaat     3480

aggcacagcc atacaagtca aaatgcccaa gagtcacaag gctattcaag cagacggttg     3540

gatgtgtcat gcttccaaat gggtcactac ttgtgatttc cgctggtatg gaccgaagta     3600

tataacacag tccatccgat ccttcactcc atctgtagaa caatgcaagg aaagcattga     3660

acaaacgaaa caaggaactt ggctgaatcc aggcttccct cctcaaagtt gtggatatgc     3720

aactgtgacg gatgccgaag cagtgattgt ccaggtgact cctcaccatg tgctggttga     3780

tgaatacaca ggagaatggg ttgattcaca gttcatcaac ggaaaatgca gcaattacat     3840

atgccccact gtccataact ctacaacctg gcattctgac tataaggtca aagggctatg     3900

tgattctaac ctcatttcca tggacatcac cttcttctca gaggacggag agctatcatc     3960

cctgggaaag gagggcacag ggttcagaag taactacttt gcttatgaaa ctggaggcaa     4020

ggcctgcaaa atgcaatact gcaagcattg gggagtcaga ctcccatcag gtgtctggtt     4080

cgagatggct gataaggatc tctttgctgc agccagattc cctgaatgcc cagaagggtc     4140

aagtatctct gctccatctc agacctcagt ggatgtaagt ctaattcagg acgttgagag     4200

gatcttggat tattccctct gccaagaaac ctggagcaaa atcagagcgg gtcttccaat     4260

ctctccagtg gatctcagct atcttgctcc taaaaaccca ggaaccggtc ctgctttcac     4320

cataatcaat ggtaccctaa aatactttga gaccagatac atcagagtcg atattgctgc     4380

tccaatcctc tcaagaatgg tcggaatgat cagtggaact accacagaaa gggaactgtg     4440

ggatgactgg gcaccatatg aagacgtgga aattggaccc aatggagttc tgaggaccag     4500

ttcaggatat aagtttcctt tatacatgat tggacatggt atgttggact ccgatcttca     4560

tcttagctca aaggctcagg tgttcgaaca tcctcacatt caagacgctg cttcgcaact     4620

tcctgatgat gagagtttat tttttggtga tactgggcta tccaaaaatc caatcgagct     4680

tgtagaaggt tggttcagta gttggaaaag ctctattgcc tcttttttct ttatcatagg     4740

gttaatcatt ggactattct tggttctccg agttggtatc catctttgca ttaaattaaa     4800

gcacaccaag aaaagacaga tttatacaga catagagatg aaccgacttg gaaagtaact     4860

caaatcctgc acaacagatt cttcatgttt ggaccaaatc aacttgtgat accatgctca     4920

aagaggcctc aattatattt gagtttttaa tttttatgga attctgcaga tatccatcac     4980

actggcggcc gctcgagcat gcatctagag ggccctattc tatagtgtca cctaaatgct     5040

agagctcgct gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     5100

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     5160

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     5220

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc     5280

tctatggctt ctgaggcgga aagaaccagc tgcattaatg aatcggccaa cgcgcgggga     5340

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     5400

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     5460

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     5520

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     5580

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     5640

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     5700

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca atgctcacgc tgtaggtatc     5760

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     5820

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     5880

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     5940

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     6000

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     6060

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     6120

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     6180

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     6240

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     6300

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     6360

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     6420

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     6480

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     6540

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     6600

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     6660

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     6720

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     6780

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     6840

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     6900

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag     6960

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     7020

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     7080

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     7140

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     7200

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     7260

gggttccgcg cacatttccc cgaaaagtgc cacctgac                             7298


<210>  37
<211>  9932
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLV4301G38A1

<400>  37
cgataaccct aattcgatag catatgcttc ccgttgggta acatatgcta ttgaattagg       60

gttagtctgg atagtatata ctactacccg ggaagcatat gctacccgtt tagggttcac      120

cggtgatgcc ggccacgatg cgtccggcgt agaggatcta atgtgagtta gctcactcat      180

taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc      240

ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg cgcaattaac      300

cctcactaaa gggaacaaaa gctggagctg caagcttaat gtagtcttat gcaatactct      360

tgtagtcttg caacatggta acgatgagtt agcaacatgc cttacaagga gagaaaaagc      420

accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac      480

agacgggtct gacatggatt ggacgaacca ctgaattgcc gcattgcaga gatattgtat      540

ttaagtgcct agctcgatac ataaacgggt ctctctggtt agaccagatc tgagcctggg      600

agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc      660

ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct      720

tttagtcagt gtggaaaatc tctagcagtg gcgcccgaac agggacttga aagcgaaagg      780

gaaaccagag gagctctctc gacgcaggac tcggcttgct gaagcgcgca cggcaagagg      840

cgaggggcgg cgactggtga gtacgccaaa aattttgact agcggaggct agaaggagag      900

agatgggtgc gagagcgtca gtattaagcg ggggagaatt agatcgcgat gggaaaaaat      960

tcggttaagg ccagggggaa agaaaaaata taaattaaaa catatagtat gggcaagcag     1020

ggagctagaa cgattcgcag ttaatcctgg cctgttagaa acatcagaag gctgtagaca     1080

aatactggga cagctacaac catcccttca gacaggatca gaagaactta gatcattata     1140

taatacagta gcaaccctct attgtgtgca tcaaaggata gagataaaag acaccaagga     1200

agctttagac aagatagagg aagagcaaaa caaaagtaag accaccgcac agcaagcggc     1260

cgctgatctt cagacctgga ggaggagata tgagggacaa ttggagaagt gaattatata     1320

aatataaagt agtaaaaatt gaaccattag gagtagcacc caccaaggca aagagaagag     1380

tggtgcagag agaaaaaaga gcagtgggaa taggagcttt gttccttggg ttcttgggag     1440

cagcaggaag cactatgggc gcagcgtcaa tgacgctgac ggtacaggcc agacaattat     1500

tgtctggtat agtgcagcag cagaacaatt tgctgagggc tattgaggcg caacagcatc     1560

tgttgcaact cacagtctgg ggcatcaagc agctccaggc aagaatcctg gctgtggaaa     1620

gatacctaaa ggatcaacag ctcctgggga tttggggttg ctctggaaaa ctcatttgca     1680

ccactgctgt gccttggaat gctagttgga gtaataaatc tctggaacag atttggaatc     1740

acacgacctg gatggagtgg gacagagaaa ttaacaatta cacaagctta atacactcct     1800

taattgaaga atcgcaaaac cagcaagaaa agaatgaaca agaattattg gaattagata     1860

aatgggcaag tttgtggaat tggtttaaca taacaaattg gctgtggtat ataaaattat     1920

tcataatgat agtaggaggc ttggtaggtt taagaatagt ttttgctgta ctttctatag     1980

tgaatagagt taggcaggga tattcaccat tatcgtttca gacccacctc ccaaccccga     2040

ggggacccga caggcccgaa ggaatagaag aagaaggtgg agagagagac agagacagat     2100

ccattcgatt agtgaacgga tctcgacggt atcggtttta aaagaaaagg ggggattggg     2160

gggtacagtg caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa     2220

ttacaaaaac aaattacaaa aattcaaaat tttatcgatt ttatttagtc tccagaaaaa     2280

ggggggaatg aaagacccca cctgtaggtt tggcaagcta gcttaagtaa cgccattttg     2340

caaggcatgg aaaatacata actgagaata gagaagttca gatcaaggtt aggaacagag     2400

agacagcaga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag     2460

ggccaagaac agatggtccc cagatgcggt cccgccctca gcagtttcta gagaaccatc     2520

agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca     2580

atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc     2640

cacaacccct cactcggcgc gccagtcctc cgatagactg cgtcgcccgg gtaccgatat     2700

caccaacttt gtacaaaaaa gctgaacgat atcgccacca tgggcagcac agccattctg     2760

gccctgctgc tggcagtgct gcagggcgtg tcagctgaag tgcagctggt ggaatctggc     2820

ggcggactgg tgcagcctgg cggatctctg agactgagct gtgccgccag cggcttcacc     2880

ttcagcaact acgccatgag ctgggtgcgc caggcccctg gaaaaggcct ggaatgggtg     2940

tccaccatca gcggctctgg cggaaccacc tactacgccg atagcgtgaa gggccggttc     3000

accatctccc gggacaacag caagaacacc ctgtacctgc agatgaacag cctgcgggtg     3060

gaagataccg ccgtgtacta ctgcgccaag gactggttca gaagcagcag ccccgacgcc     3120

ttcgacatct ggggccaggg aacaaccgtg accgtgtctg ctggcggagg cggatcaggc     3180

ggcggaggat cagggggagg cggaagcgga gcaccttctt acgtgctgac ccagccccct     3240

agcgtgtcag tggctcctgg acagaccgcc agaatcacct gtggcggcaa caacatcggc     3300

cggaagatcg tgcactggta tcagcagagg cccggacagg ctcccgtgct cgtgatctac     3360

tacgacaccg acagacctgc cggcatcccc gagagattca gcggcagcaa cagcggcaac     3420

atggccaccc tgaccatcag cacagtggga gccggcgacg aggccgacta ctactgtcaa     3480

gtgtgggaca ccggcagcga tcacgtggtg tttggaggcg gcaccaagct gacagtgctg     3540

ggcccgcggg ccaactttgt atacaaaagt tgcagcgaga gcaagtacgg ccctccctgc     3600

cccccttgcc ctgcccccga gttcctgggc ggacccagcg tgttcctgtt cccccccaag     3660

cccaaggaca ccctgatgat cagccggacc cccgaggtga cctgtgtggt ggtggacgtg     3720

tcccaggagg accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcacaac     3780

gccaagacca agccccggga ggagcagttc aatagcacct accgggtggt gtccgtgctg     3840

accgtgctgc accaggactg gctgaacggc aaggaataca agtgtaaggt gtccaacaag     3900

ggcctgccca gcagcatcga gaaaaccatc agcaaggcca agggccagcc tcgggagccc     3960

caggtgtaca ccctgccccc tagccaagag gagatgacca agaatcaggt gtccctgacc     4020

tgcctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag caacggccag     4080

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggcag cttcttcctg     4140

tacagcaggc tgaccgtgga caagagccgg tggcaggagg gcaacgtctt tagctgctcc     4200

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgtccct gagcctgggc     4260

aagatgttca gatcttgtga tatttacatc tgggcaccct tggccggaat ctgcgtggcc     4320

cttctgctgt ccttgatcat cactctcatc tgctacggct ccaccagcgg ctccggcaag     4380

cccggctctg gcgagggctc caccagcggc gactacaagg acgacgatga caagtaatag     4440

gatatcggtt cagctttctt gtacaaagtt gggattcgag ttaattaagt taacgaattc     4500

cccccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg     4560

tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc     4620

cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa     4680

ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga     4740

caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc     4800

ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc     4860

cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac     4920

aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg     4980

tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaacg tctaggcccc ccgaaccacg     5040

gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaaccat gggaggcgga     5100

agcggcggag gctcccctcg aggcaccatg gtgagcaagg gcgaggagct gttcaccggg     5160

gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc     5220

ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc     5280

ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc     5340

ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa     5400

ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc     5460

gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc     5520

aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc     5580

tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat ccgccacaac     5640

atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac     5700

ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct gagcaaagac     5760

cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc cgggatcact     5820

ctcggcatgg acgagctgta caagtaacgc gtcccgggtc tagagctagc ggtaccatgc     5880

attacgtagt cgacgactta attaagctag cctagtgcca tttgttcagt ggttcgtagg     5940

gctttccccc actgtttggc tttcagttat atggatgatg tggtattggg ggccaagtct     6000

gtacagcatc ttgagtccct ttttaccgct gttaccaatt ttcttttgtc tttgggtata     6060

catttaaacc ctaacaaaac aaagagatgg ggttactctc taaattttat gggttatgtc     6120

attggatgtt atgggtcctt gccacaagaa cacatcatac aaaaaatcaa agaatgtttt     6180

agaaaacttc ctattaacag gcctattgat tggaaagtat gtcaacgaat tgtgggtctt     6240

ttgggttttg ctgccccttt tacacaatgt ggttatcctg cgttgatgcc tttgtatgca     6300

tgtattcaat ctaagcaggc tttcactttc tcgccaactt acaaggcctt tctgtgtaaa     6360

caatacctga acctttaccc cgttgcccgg caacggccag gtctgtgcca agtgtttgct     6420

gacgcaaccc ccactggctg gggcttggtc atgggccatc agcgcatgcg tggaaccttt     6480

tcggctcctc tgccgatcca tactgcggaa ctcctagccg cttgttttgc tcgcagcagg     6540

tctggagcaa acattatcgg gactgataac tctgttgtcc tatcccgcaa atatacatcg     6600

tttccatggc tgctaggctg tgctgccaac tggatcctgc gcgggacgtc ctttgtttac     6660

gtcccgtcgg cgctgaatcc tgcggacgac ccttctcggg gtcgcttggg actctctcgt     6720

ccccttctcc gtctgccgtt ccgaccgacc acggggcgca cctctcttta cgcggactcc     6780

ccgtctgtgc cttctcatct gccggaccgt gtgcacttcg cttcacctct gcacgtcgca     6840

tggagaccac cgtgaacgcc caccaaatat tgcccaaggt cttacataag aggactcttg     6900

gactctcagc aatgtcaacg accgaccttg aggcatactt caaagactgt ttgtttaaag     6960

actgggagga gttgggggag gagattaggt taaaggtctt tgtactagga ggctgtaggc     7020

ataaattggt ctgcgcacca gcaccatggc gcaatcacta gagcggggta cctttaagac     7080

caatgactta caaggcagct gtagatctta gccacttttt aaaagaaaag gggggactgg     7140

aagggctaat tcactcccaa cgaagacaag atctgctttt tgcttgtact gggtctctct     7200

ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc     7260

ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg     7320

gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc agtagtagtt     7380

catgtcatct tattattcag tatttataac ttgcaaagaa atgaatatca gagagtgaga     7440

ggaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     7500

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     7560

cttatcatgt ctggctctag ctatcccgcc cctaactccg cccatcccgc ccctaactcc     7620

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc     7680

cgaggccgga tcccttgagt ggctttcatc ctggagcaga ctttgcagtc tgtggactgc     7740

aacacaacat tgcctttatg tgtaactctt ggctgaagct cttacaccaa tgctggggga     7800

catgtacctc ccaggggccc aggaagacta cgggaggcta caccaacgtc aatcagaggg     7860

gcctgtgtag ctaccgataa gcggaccctc aagagggcat tagcaatagt gtttataagg     7920

cccccttgtt aattcttgaa gacgaaaggg cctcgtgata cgcctatttt tataggttaa     7980

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg     8040

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     8100

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     8160

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     8220

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     8280

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat     8340

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtgttgacg ccgggcaaga     8400

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac     8460

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat     8520

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac     8580

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct     8640

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgcagcaa tggcaacaac     8700

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga     8760

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg     8820

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact     8880

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac     8940

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta     9000

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt     9060

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga     9120

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc     9180

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt     9240

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc     9300

gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc     9360

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg     9420

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg     9480

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga     9540

actgagatac ctacagcgtg agcattgaga aagcgccacg cttcccgaag ggagaaaggc     9600

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg     9660

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg     9720

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt     9780

tttacggttc ctggcctttt gctggccttt ttgaagctgt ccctgatggt cgtcatctac     9840

ctgcctggac agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat     9900

cataatgggg aaggccatcc agcctcgcgt cg                                   9932


<210>  38
<211>  9932
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PLV4301G19H9

<400>  38
cgataaccct aattcgatag catatgcttc ccgttgggta acatatgcta ttgaattagg       60

gttagtctgg atagtatata ctactacccg ggaagcatat gctacccgtt tagggttcac      120

cggtgatgcc ggccacgatg cgtccggcgt agaggatcta atgtgagtta gctcactcat      180

taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc      240

ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagcg cgcaattaac      300

cctcactaaa gggaacaaaa gctggagctg caagcttaat gtagtcttat gcaatactct      360

tgtagtcttg caacatggta acgatgagtt agcaacatgc cttacaagga gagaaaaagc      420

accgtgcatg ccgattggtg gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac      480

agacgggtct gacatggatt ggacgaacca ctgaattgcc gcattgcaga gatattgtat      540

ttaagtgcct agctcgatac ataaacgggt ctctctggtt agaccagatc tgagcctggg      600

agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc      660

ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct      720

tttagtcagt gtggaaaatc tctagcagtg gcgcccgaac agggacttga aagcgaaagg      780

gaaaccagag gagctctctc gacgcaggac tcggcttgct gaagcgcgca cggcaagagg      840

cgaggggcgg cgactggtga gtacgccaaa aattttgact agcggaggct agaaggagag      900

agatgggtgc gagagcgtca gtattaagcg ggggagaatt agatcgcgat gggaaaaaat      960

tcggttaagg ccagggggaa agaaaaaata taaattaaaa catatagtat gggcaagcag     1020

ggagctagaa cgattcgcag ttaatcctgg cctgttagaa acatcagaag gctgtagaca     1080

aatactggga cagctacaac catcccttca gacaggatca gaagaactta gatcattata     1140

taatacagta gcaaccctct attgtgtgca tcaaaggata gagataaaag acaccaagga     1200

agctttagac aagatagagg aagagcaaaa caaaagtaag accaccgcac agcaagcggc     1260

cgctgatctt cagacctgga ggaggagata tgagggacaa ttggagaagt gaattatata     1320

aatataaagt agtaaaaatt gaaccattag gagtagcacc caccaaggca aagagaagag     1380

tggtgcagag agaaaaaaga gcagtgggaa taggagcttt gttccttggg ttcttgggag     1440

cagcaggaag cactatgggc gcagcgtcaa tgacgctgac ggtacaggcc agacaattat     1500

tgtctggtat agtgcagcag cagaacaatt tgctgagggc tattgaggcg caacagcatc     1560

tgttgcaact cacagtctgg ggcatcaagc agctccaggc aagaatcctg gctgtggaaa     1620

gatacctaaa ggatcaacag ctcctgggga tttggggttg ctctggaaaa ctcatttgca     1680

ccactgctgt gccttggaat gctagttgga gtaataaatc tctggaacag atttggaatc     1740

acacgacctg gatggagtgg gacagagaaa ttaacaatta cacaagctta atacactcct     1800

taattgaaga atcgcaaaac cagcaagaaa agaatgaaca agaattattg gaattagata     1860

aatgggcaag tttgtggaat tggtttaaca taacaaattg gctgtggtat ataaaattat     1920

tcataatgat agtaggaggc ttggtaggtt taagaatagt ttttgctgta ctttctatag     1980

tgaatagagt taggcaggga tattcaccat tatcgtttca gacccacctc ccaaccccga     2040

ggggacccga caggcccgaa ggaatagaag aagaaggtgg agagagagac agagacagat     2100

ccattcgatt agtgaacgga tctcgacggt atcggtttta aaagaaaagg ggggattggg     2160

gggtacagtg caggggaaag aatagtagac ataatagcaa cagacataca aactaaagaa     2220

ttacaaaaac aaattacaaa aattcaaaat tttatcgatt ttatttagtc tccagaaaaa     2280

ggggggaatg aaagacccca cctgtaggtt tggcaagcta gcttaagtaa cgccattttg     2340

caaggcatgg aaaatacata actgagaata gagaagttca gatcaaggtt aggaacagag     2400

agacagcaga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag     2460

ggccaagaac agatggtccc cagatgcggt cccgccctca gcagtttcta gagaaccatc     2520

agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca     2580

atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc     2640

cacaacccct cactcggcgc gccagtcctc cgatagactg cgtcgcccgg gtaccgatat     2700

caccaacttt gtacaaaaaa gctgaacgat atcgccacca tgggcagcac agccattctg     2760

gccctgctgc tggcagtgct gcagggcgtg tcagctgaag tgcagctggt ggaatctggc     2820

ggcggactgg tgcagcctgg cggatctctg agactgagct gtgccgccag cggcttcacc     2880

ttcagcaact acgccatgag ctgggtgcgc caggcccctg gaaaaggcct ggaatgggtg     2940

tccaccatca gcggctctgg cggaaccacc tactacgccg atagcgtgaa gggccggttc     3000

accatctccc gggacaacag caagaacacc ctgtacctgc agatgaacag cctgcgggtg     3060

gaagataccg ccgtgtacta ctgcgccaag gactggttca gaagcagcag ccccgacgcc     3120

ttcgacatct ggggccaggg aacaaccgtg accgtgtctg ctggcggagg cggatcaggc     3180

ggcggaggat cagggggagg cggaagcgga gcaccttctt acgtgctgac ccagccccct     3240

agcgtgtcag tggctcctgg acagaccgcc agaatcacct gtggcggcaa caacatcggc     3300

cggaagatcg tgcactggta tcagcagagg cccggacagg ctcccgtgct cgtgatctac     3360

tacgacaccg acagacctgc cggcatcccc gagagattca gcggcagcaa cagcggcaac     3420

atggccaccc tgaccatcag cacagtggga gccggcgacg aggccgacta ctactgtcaa     3480

gtgtgggaca ccggcagcga tcacgtggtg tttggaggcg gcaccaagct gacagtgctg     3540

ggcccgcggg ccaactttgt atacaaaagt tgcagcgaga gcaagtacgg ccctccctgc     3600

cccccttgcc ctgcccccga gttcctgggc ggacccagcg tgttcctgtt cccccccaag     3660

cccaaggaca ccctgatgat cagccggacc cccgaggtga cctgtgtggt ggtggacgtg     3720

tcccaggagg accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcacaac     3780

gccaagacca agccccggga ggagcagttc aatagcacct accgggtggt gtccgtgctg     3840

accgtgctgc accaggactg gctgaacggc aaggaataca agtgtaaggt gtccaacaag     3900

ggcctgccca gcagcatcga gaaaaccatc agcaaggcca agggccagcc tcgggagccc     3960

caggtgtaca ccctgccccc tagccaagag gagatgacca agaatcaggt gtccctgacc     4020

tgcctggtga agggcttcta ccccagcgac atcgccgtgg agtgggagag caacggccag     4080

cccgagaaca actacaagac caccccccct gtgctggaca gcgacggcag cttcttcctg     4140

tacagcaggc tgaccgtgga caagagccgg tggcaggagg gcaacgtctt tagctgctcc     4200

gtgatgcacg aggccctgca caaccactac acccagaaga gcctgtccct gagcctgggc     4260

aagatgttca gatcttgtga tatttacatc tgggcaccct tggccggaat ctgcgtggcc     4320

cttctgctgt ccttgatcat cactctcatc tgctacggct ccaccagcgg ctccggcaag     4380

cccggctctg gcgagggctc caccagcggc gactacaagg acgacgatga caagtaatag     4440

gatatcggtt cagctttctt gtacaaagtt gggattcgag ttaattaagt taacgaattc     4500

cccccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg     4560

tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc     4620

cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa     4680

ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga     4740

caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc     4800

ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc     4860

cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac     4920

aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg     4980

tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaacg tctaggcccc ccgaaccacg     5040

gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaaccat gggaggcgga     5100

agcggcggag gctcccctcg aggcaccatg gtgagcaagg gcgaggagct gttcaccggg     5160

gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt cagcgtgtcc     5220

ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat ctgcaccacc     5280

ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc tgacctacgg cgtgcagtgc     5340

ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc catgcccgaa     5400

ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa gacccgcgcc     5460

gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg catcgacttc     5520

aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag ccacaacgtc     5580

tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat ccgccacaac     5640

atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc catcggcgac     5700

ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct gagcaaagac     5760

cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc cgggatcact     5820

ctcggcatgg acgagctgta caagtaacgc gtcccgggtc tagagctagc ggtaccatgc     5880

attacgtagt cgacgactta attaagctag cctagtgcca tttgttcagt ggttcgtagg     5940

gctttccccc actgtttggc tttcagttat atggatgatg tggtattggg ggccaagtct     6000

gtacagcatc ttgagtccct ttttaccgct gttaccaatt ttcttttgtc tttgggtata     6060

catttaaacc ctaacaaaac aaagagatgg ggttactctc taaattttat gggttatgtc     6120

attggatgtt atgggtcctt gccacaagaa cacatcatac aaaaaatcaa agaatgtttt     6180

agaaaacttc ctattaacag gcctattgat tggaaagtat gtcaacgaat tgtgggtctt     6240

ttgggttttg ctgccccttt tacacaatgt ggttatcctg cgttgatgcc tttgtatgca     6300

tgtattcaat ctaagcaggc tttcactttc tcgccaactt acaaggcctt tctgtgtaaa     6360

caatacctga acctttaccc cgttgcccgg caacggccag gtctgtgcca agtgtttgct     6420

gacgcaaccc ccactggctg gggcttggtc atgggccatc agcgcatgcg tggaaccttt     6480

tcggctcctc tgccgatcca tactgcggaa ctcctagccg cttgttttgc tcgcagcagg     6540

tctggagcaa acattatcgg gactgataac tctgttgtcc tatcccgcaa atatacatcg     6600

tttccatggc tgctaggctg tgctgccaac tggatcctgc gcgggacgtc ctttgtttac     6660

gtcccgtcgg cgctgaatcc tgcggacgac ccttctcggg gtcgcttggg actctctcgt     6720

ccccttctcc gtctgccgtt ccgaccgacc acggggcgca cctctcttta cgcggactcc     6780

ccgtctgtgc cttctcatct gccggaccgt gtgcacttcg cttcacctct gcacgtcgca     6840

tggagaccac cgtgaacgcc caccaaatat tgcccaaggt cttacataag aggactcttg     6900

gactctcagc aatgtcaacg accgaccttg aggcatactt caaagactgt ttgtttaaag     6960

actgggagga gttgggggag gagattaggt taaaggtctt tgtactagga ggctgtaggc     7020

ataaattggt ctgcgcacca gcaccatggc gcaatcacta gagcggggta cctttaagac     7080

caatgactta caaggcagct gtagatctta gccacttttt aaaagaaaag gggggactgg     7140

aagggctaat tcactcccaa cgaagacaag atctgctttt tgcttgtact gggtctctct     7200

ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc     7260

ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg     7320

gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc agtagtagtt     7380

catgtcatct tattattcag tatttataac ttgcaaagaa atgaatatca gagagtgaga     7440

ggaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     7500

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     7560

cttatcatgt ctggctctag ctatcccgcc cctaactccg cccatcccgc ccctaactcc     7620

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc     7680

cgaggccgga tcccttgagt ggctttcatc ctggagcaga ctttgcagtc tgtggactgc     7740

aacacaacat tgcctttatg tgtaactctt ggctgaagct cttacaccaa tgctggggga     7800

catgtacctc ccaggggccc aggaagacta cgggaggcta caccaacgtc aatcagaggg     7860

gcctgtgtag ctaccgataa gcggaccctc aagagggcat tagcaatagt gtttataagg     7920

cccccttgtt aattcttgaa gacgaaaggg cctcgtgata cgcctatttt tataggttaa     7980

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg     8040

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     8100

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     8160

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     8220

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     8280

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat     8340

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtgttgacg ccgggcaaga     8400

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac     8460

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat     8520

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac     8580

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct     8640

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgcagcaa tggcaacaac     8700

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga     8760

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg     8820

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact     8880

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac     8940

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta     9000

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt     9060

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga     9120

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc     9180

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt     9240

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc     9300

gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc     9360

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg     9420

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg     9480

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga     9540

actgagatac ctacagcgtg agcattgaga aagcgccacg cttcccgaag ggagaaaggc     9600

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg     9660

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg     9720

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt     9780

tttacggttc ctggcctttt gctggccttt ttgaagctgt ccctgatggt cgtcatctac     9840

ctgcctggac agcatggcct gcaacgcggg catcccgatg ccgccggaag cgagaagaat     9900

cataatgggg aaggccatcc agcctcgcgt cg                                   9932


<210>  39
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1

<400>  39

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  40
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2

<400>  40

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  41
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG3

<400>  41

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  42
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


