                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  METHODS AND COMPOSITIONS FOR TREATMENT OF DISORDERS AND DISEASES 
       INVOLVING RDH12

<130>  UPN-16-7699PCT

<150>  US 62/359,777
<151>  2016-07-08

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  949
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctggtca ccttgggact gctcacctcc ttcttctcgt tcctgtatat ggtagctcca       60

tccatcagga agttctttgc tggtggagtg tgtagaacaa atgtgcagct tcctggcaag      120

gtagtggtga tcactggcgc caacacgggc attggcaagg agacggccag agagctcgct      180

agccgaggag cccgagtcta tattgcctgc agagatgtac tgaaggggga gtctgctgcc      240

agtgaaatcc gagtggatac aaagaactcc caggtgctgg tgcggaaatt ggacctatcc      300

gacaccaaat ctatccgagc ctttgctgag ggctttctgg cagaggaaaa gcagctccat      360

attctgatca acaatgcggg agtaatgatg tgtccatatt ccaagacagc tgatggcttt      420

gaaacccacc tgggagtcaa ccacctgggc cacttcctcc tcacctacct gctcctggag      480

cggctaaagg tgtctgcccc tgcacgggtg gttaatgtgt cctcggtggc tcaccacatt      540

ggcaagattc ccttccacga cctccagagc gagaagcgct acagcagggg ttttgcctat      600

tgccacagca agctggccaa tgtgcttttt actcgtgagc tggccaagag gctccaaggc      660

accggggtca ccacctacgc agtgcaccca ggcgtcgtcc gctctgagct ggtccggcac      720

tcctccctgc tctgcctgct ctggcggctc ttctccccct ttgtcaagac ggcacgggag      780

ggggcgcaga ccagcctgca ctgcgccctg gctgagggcc tggagcccct gagtggcaag      840

tacttcagtg actgcaagag gacctgggtg tctccaaggg cccgaaataa caaaacagct      900

gagcgcctat ggaatgtcag ctgtgagctt ctaggaatcc ggtgggagt                  949


<210>  2
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Val Thr Leu Gly Leu Leu Thr Ser Phe Phe Ser Phe Leu Tyr 
1               5                   10                  15      


Met Val Ala Pro Ser Ile Arg Lys Phe Phe Ala Gly Gly Val Cys Arg 
            20                  25                  30          


Thr Asn Val Gln Leu Pro Gly Lys Val Val Val Ile Thr Gly Ala Asn 
        35                  40                  45              


Thr Gly Ile Gly Lys Glu Thr Ala Arg Glu Leu Ala Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Tyr Ile Ala Cys Arg Asp Val Leu Lys Gly Glu Ser Ala Ala 
65                  70                  75                  80  


Ser Glu Ile Arg Val Asp Thr Lys Asn Ser Gln Val Leu Val Arg Lys 
                85                  90                  95      


Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe Ala Glu Gly Phe 
            100                 105                 110         


Leu Ala Glu Glu Lys Gln Leu His Ile Leu Ile Asn Asn Ala Gly Val 
        115                 120                 125             


Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly Phe Glu Thr His Leu 
    130                 135                 140                 


Gly Val Asn His Leu Gly His Phe Leu Leu Thr Tyr Leu Leu Leu Glu 
145                 150                 155                 160 


Arg Leu Lys Val Ser Ala Pro Ala Arg Val Val Asn Val Ser Ser Val 
                165                 170                 175     


Ala His His Ile Gly Lys Ile Pro Phe His Asp Leu Gln Ser Glu Lys 
            180                 185                 190         


Arg Tyr Ser Arg Gly Phe Ala Tyr Cys His Ser Lys Leu Ala Asn Val 
        195                 200                 205             


Leu Phe Thr Arg Glu Leu Ala Lys Arg Leu Gln Gly Thr Gly Val Thr 
    210                 215                 220                 


Thr Tyr Ala Val His Pro Gly Val Val Arg Ser Glu Leu Val Arg His 
225                 230                 235                 240 


Ser Ser Leu Leu Cys Leu Leu Trp Arg Leu Phe Ser Pro Phe Val Lys 
                245                 250                 255     


Thr Ala Arg Glu Gly Ala Gln Thr Ser Leu His Cys Ala Leu Ala Glu 
            260                 265                 270         


Gly Leu Glu Pro Leu Ser Gly Lys Tyr Phe Ser Asp Cys Lys Arg Thr 
        275                 280                 285             


Trp Val Ser Pro Arg Ala Arg Asn Asn Lys Thr Ala Glu Arg Leu Trp 
    290                 295                 300                 


Asn Val Ser Cys Glu Leu Leu Gly Ile Arg Trp Glu 
305                 310                 315     


<210>  3
<211>  686
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized RDH12 DNA sequence.

<400>  3
gcggccgcca ccatgttggt caccctcgga ctccttacct catttttctc cttcctgtac       60

atggtcgccc cgagcattag aaagttcttc gccggcggag tgtgtaggac taacgtgcag      120

ttgcccggga aggtcgtggt gattactggc gccaacactg gtatcggaaa ggaaactgcg      180

cgggaactgg cgtccagagg tgcccgcgtg tacattgcat gccgcgacgt gctgaaggga      240

gaatccgccg cgtccgagat ccgggtggac accaaaaata gccaggtgct cgtgcggaag      300

ctggatctgt ccgacaccaa gtcaatcagg gcctttgccg aggggttcct ggctgaagag      360

aagcagctcc acattctgat caacaacgcc ggggtcatga tgtgccccta ctcaaagacc      420

gcagacggct tcgaaaccca cctgggcgtg aaccatctgg gacacttcct gctgacctat      480

ctgctgctgg agcgactgaa agtgtcggct cctgctcggg tcgtgaacgt gtccagcgtg      540

gcccatcaca tcggaaagat cccattccac gatctccaat ccgagaagcg gtacagcagg      600

ggcttcgcgt actgtcactc gaagttggcc aacgtgctct ttacccgcga actggccaag      660

cggctgcagg gcactggcgt gaccac                                           686


<210>  4
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Translated functional RDH12 protein sequence.

<400>  4

Ala Ala Ala Thr Met Leu Val Thr Leu Gly Leu Leu Thr Ser Phe Phe 
1               5                   10                  15      


Ser Phe Leu Tyr Met Val Ala Pro Ser Ile Arg Lys Phe Phe Ala Gly 
            20                  25                  30          


Gly Val Cys Arg Thr Asn Val Gln Leu Pro Gly Lys Val Val Val Ile 
        35                  40                  45              


Thr Gly Ala Asn Thr Gly Ile Gly Lys Glu Thr Ala Arg Glu Leu Ala 
    50                  55                  60                  


Ser Arg Gly Ala Arg Val Tyr Ile Ala Cys Arg Asp Val Leu Lys Gly 
65                  70                  75                  80  


Glu Ser Ala Ala Ser Glu Ile Arg Val Asp Thr Lys Asn Ser Gln Val 
                85                  90                  95      


Leu Val Arg Lys Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe 
            100                 105                 110         


Ala Glu Gly Phe Leu Ala Glu Glu Lys Gln Leu His Ile Leu Ile Asn 
        115                 120                 125             


Asn Ala Gly Val Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly Phe 
    130                 135                 140                 


Glu Thr His Leu Gly Val Asn His Leu Gly His Phe Leu Leu Thr Tyr 
145                 150                 155                 160 


Leu Leu Leu Glu Arg Leu Lys Val Ser Ala Pro Ala Arg Val Val Asn 
                165                 170                 175     


Val Ser Ser Val Ala His His Ile Gly Lys Ile Pro Phe His Asp Leu 
            180                 185                 190         


Gln Ser Glu Lys Arg Tyr Ser Arg Gly Phe Ala Tyr Cys His Ser Lys 
        195                 200                 205             


Leu Ala Asn Val Leu Phe Thr Arg Glu Leu Ala Lys Arg Leu Gln Gly 
    210                 215                 220                 


Thr Gly Val Thr Thr Tyr Ala Val His Pro Gly Val Val Arg Ser Glu 
225                 230                 235                 240 


Leu Val Arg His Ser Ser Leu Leu Cys Leu Leu Trp Arg Leu Phe Ser 
                245                 250                 255     


Pro Phe Val Lys Thr Ala Arg Glu Gly Ala Gln Thr Ser Leu His Cys 
            260                 265                 270         


Ala Leu Ala Glu Gly Leu Glu Pro Leu Ser Gly Lys Tyr Phe Ser Asp 
        275                 280                 285             


Cys Lys Arg Thr Trp Val Ser Pro Arg Ala Arg Asn Asn Lys Thr Ala 
    290                 295                 300                 


Glu Arg Leu Trp Asn Val Ser Cys Glu Leu Leu Gly Ile Arg Trp Glu 
305                 310                 315                 320 


