
                                SEQUENCE LISTING

<110> Genentech, Inc.
      LACKNER, Mark
      MASLYAR, Daniel
      WANG, Yulei
      DARBONNE, Walter
      HUMKE, Eric

<120> USE OF HUMAN EPIDIDYMIS PROTEIN 4 (HE4)
  FOR ASSESSING RESPONSIVENESS OF CANCER TREATMENT
  

<130> 146392033240

<140> Not Yet Assigned      
<141> Concurrently Herewith

<150> US 62/360,027       
<151> 2016-07-08  

<160> 18

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 1
Lys Ala Ser Asp Leu Ile His Asn Trp Leu Ala
 1               5                  10      


<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 2
Tyr Gly Ala Thr Ser Leu Glu Thr
 1               5              


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 3
Gln Gln Tyr Trp Thr Thr Pro Phe Thr
 1               5                  


<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 4
Gly Tyr Ser Ile Thr Asn Asp Tyr Ala Trp Asn
 1               5                  10      


<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 5
Gly Tyr Ile Ser Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu Lys
 1               5                  10                  15      
Ser
    


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 6
Ala Arg Trp Thr Ser Gly Leu Asp Tyr
 1               5                  


<210> 7
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 7
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Leu Ile His Asn Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Phe
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 8
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 8
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Asn Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Val Gly Tyr Ile Ser Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Thr Ser Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 9
Ser Gly Ala Thr Ser Leu Glu Thr
 1               5              


<210> 10
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 10
Gly Tyr Ile Asn Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu
 1               5                  10                  15  


<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 11
Ala Arg Trp Asp Gly Gly Leu Thr Tyr
 1               5                  


<210> 12
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 12
Asp Ile Gln Met Thr Gln Ser Ser Ser Phe Leu Ser Val Ser Leu Gly
 1               5                  10                  15      
Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Leu Ile His Asn Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Asn Asp Tyr Thr Leu Ser Ile Ala Ser Leu Gln Thr
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Phe
                85                  90                  95      
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 13
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 13
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Asn Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Asn Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Ile Asn Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Asp Gly Gly Leu Thr Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ala
        115     


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 14
Ala Arg Trp Ala Ser Gly Leu Asp Tyr
 1               5                  


<210> 15
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Asn Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Val Gly Tyr Ile Ser Tyr Ser Gly Tyr Thr Thr Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Ala Ser Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 16
Gly Tyr Ile Asn Tyr Ala Gly Tyr Thr Thr Tyr Asn Pro Ser Leu Lys
 1               5                  10                  15      
Ser
    


<210> 17
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Asn Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Val Gly Tyr Ile Asn Tyr Ala Gly Tyr Thr Thr Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Ala Ser Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 18
<211> 124
<212> PRT
<213> Homo sapiens

<400> 18
Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser
 1               5                  10                  15      
Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys
            20                  25                  30          
Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu
        35                  40                  45              
Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala
    50                  55                  60                  
Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Asp Lys Glu Gly Ser Cys
65                  70                  75                  80  
Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln
                85                  90                  95      
Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn
            100                 105                 110         
Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe
        115                 120                 

