                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  CHIMERIC WEST NILE/ZIKA VIRUSES AND METHODS OF USE

<130>  4239-97038-02

<150>  US 62/359,807
<151>  2016-07-08

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  11041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc      120

ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt      180

ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg      240

gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga      300

tggagaggtg tgaacaaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta      360

gggaccttga ccagtgctat caatcggcgg agttcgaaac aaaagaaaag aggaggaaag      420

accggaattg cagtcatgat tggcctgatc gccagcgcta tggcagcgga ggtcactaga      480

cgtgggagtg catactatat gtacttggac agaaacgatg ctggggaggc catatctttt      540

ccaaccacat tggggatgaa taagtgttat atacagatca tggatcttgg acacatgtgt      600

gatgccacca tgagctatga atgccctatg ctggatgagg gggtggaacc agatgacgtc      660

gattgttggt gcaacacgac gtcaacttgg gttgtgtacg gaacctgcca tcacaaaaaa      720

ggtgaagcac ggagaagtag aagagctgtg acgctcccct cccattccac taggaagctg      780

caaacgcggt cgcaaacctg gttggaatca agagaataca caaagcactt gattagagtc      840

gaaaattgga tattcaggaa ccctggcttc gcgttagcag cagctgccat cgcttggctt      900

ttgggaagct caacgagcca aaaagtcata tacttggtca tgatactgct gattgccccg      960

gcatacagca tcaggtgcat aggagtcagc aatagggact ttgtggaagg tatgtcaggt     1020

gggacttggg ttgatgttgt cttggaacat ggaggttgtg tcaccgtaat ggcacaggac     1080

aaaccgactg tcgacataga gctggttaca acaacagtca gcaacatggc ggaggtaaga     1140

tcctactgct atgaggcatc aatatcagac atggcttcgg acagccgctg cccaacacaa     1200

ggtgaagcct accttgacaa gcaatcagac actcaatatg tctgcaaaag aacgttagtg     1260

gacagaggct ggggaaatgg atgtggactt tttggcaaag ggagtctggt gacatgcgct     1320

aagtttgcat gctccaagaa aatgaccggg aagagcatcc agccagagaa tctggagtac     1380

cggataatgc tgtcagttca tggctcccag cacagtggga tgatcgttaa tgacacagga     1440

catgaaactg atgagaatag agcgaaggtt gagataacgc ccaattcacc aagagccgaa     1500

gccaccctgg ggggttttgg aagcctagga cttgattgtg aaccgaggac aggccttgac     1560

ttttcagatt tgtattactt gactatgaat aacaagcact ggttggttca caaggagtgg     1620

ttccacgaca ttccattacc ttggcacgct ggggcagaca ccggaactcc acactggaac     1680

aacaaagaag cactggtaga gttcaaggac gcacatgcca aaaggcaaac tgtcgtggtt     1740

ctagggagtc aagaaggagc agttcacacg gcccttgctg gagctctgga ggctgagatg     1800

gatggtgcaa agggaaggct gtcctctggc cacttgaaat gtcgcctgaa aatggataaa     1860

cttagattga agggcgtgtc atactccttg tgtaccgcag cgttcacatt caccaagatc     1920

ccggctgaaa cactgcacgg gacagtcaca gtggaggtac agtacgcagg gacagatgga     1980

ccttgcaagg ttccagctca gatggcggtg gacatgcaaa ctctgacccc agttgggagg     2040

ttgataaccg ctaaccccgt aatcactgaa agcactgaga actctaagat gatgctggaa     2100

cttgatccac catttgggga ctcttacatt gtcataggag tcggggagaa gaagatcacc     2160

caccactggc acaggagtgg cagcaccatt ggaaaagcat ttgaagccac tgtgagaggt     2220

gccaagagaa tggcagtctt gggagacaca gcctgggact ttggatcagt tggaggcgct     2280

ctcaactcat tgggcaaggg catccatcaa atttttggag cagctttcaa atcattgttt     2340

ggaggaatgt cctggttctc acaaattctc attggaacgt tgctgatgtg gttgggtctg     2400

aacacaaaga atggatctat ttcccttatg tgcttggcct tagggggagt gttgatcttc     2460

ttatccacag ccgtctctgc tgattccgga tgtgccatag acatcagccg gcaagagctg     2520

agatgtggaa gtggagtgtt catacacaat gatgtggagg cttggatgga ccggtacaag     2580

tattaccctg aaacgccaca aggcctagcc aagatcattc agaaagctca taaggaagga     2640

gtgtgcggtc tacgatcagt ttccagactg gagcatcaaa tgtgggaagc agtgaaggac     2700

gagctgaaca ctcttttgaa ggagaatggt gtggacctta gtgtcgtggt tgagaaacag     2760

gagggaatgt acaagtcagc acctaaacgc ctcaccgcca ccacggaaaa attggaaatt     2820

ggctggaagg cctggggaaa gagtatttta tttgcaccag aactcgccaa caacaccttt     2880

gtggttgatg gtccggagac caaggaatgt ccgactcaga atcgcgcttg gaatagctta     2940

gaagtggagg attttggatt tggtctcacc agcactcgga tgttcctgaa ggtcagagag     3000

agcaacacaa ctgaatgtga ctcgaagatc attggaacgg ctgtcaagaa caacttggcg     3060

atccacagtg acctgtccta ttggattgaa agcaggctca atgatacgtg gaagcttgaa     3120

agggcagttc tgggtgaagt caaatcatgt acgtggcctg agacgcatac cttgtggggc     3180

gatggaatcc ttgagagtga cttgataata ccagtcacac tggcgggacc acgaagcaat     3240

cacaatcgga gacctgggta caagacacaa aaccagggcc catgggacga aggccgggta     3300

gagattgact tcgattactg cccaggaact acggtcaccc tgagtgagag ctgcggacac     3360

cgtggacctg ccactcgcac caccacagag agcggaaagt tgataacaga ttggtgctgc     3420

aggagctgca ccttaccacc actgcgctac caaactgaca gcggctgttg gtatggtatg     3480

gagatcagac cacagagaca tgatgaaaag accctcgtgc agtcacaagt gaatgcttat     3540

aatgctgata tgattgaccc ttttcagttg ggccttctgg tcgtgttctt ggccacccag     3600

gaggtccttc gcaagaggtg gacagccaag atcagcatgc cagctatact gattgctctg     3660

ctagtcctgg tgtttggggg cattacttac actgatgtgt tacgctatgt catcttggtg     3720

ggggcagctt tcgcagaatc taattcggga ggagacgtgg tacacttggc gctcatggcg     3780

accttcaaga tacaaccagt gtttatggtg gcatcgtttc tcaaagcgag atggaccaac     3840

caggagaaca ttttgttgat gttggcggct gttttctttc aaatggctta ttacgatgcc     3900

cgccaaattc tgctctggga gatccctgat gtgttgaatt cactggcggt agcttggatg     3960

atactgagag ccataacatt cacaacgaca tcaaacgtgg ttgttccgct gctagccctg     4020

ctaacacccg ggctgagatg cttgaatctg gatgtgtaca ggatactgct gttgatggtc     4080

ggaataggca gcttgatcag ggagaagagg agtgcagctg caaaaaagaa aggagcaagt     4140

ctgctatgct tggctctagc ctcaacagga cttttcaacc ccatgatcct tgctgctgga     4200

ctgattgcat gtgatcccaa ccgtaaacgc ggatggcccg caactgaagt gatgacagct     4260

gtcggcctaa tgtttgccat cgtcggaggg ctggcagagc ttgacattga ctccatggcc     4320

attccaatga ctatcgcggg gctcatgttt gctgctttcg tgatttctgg gaaatcaaca     4380

gatatgtgga ttgagagaac ggcggacatt tcctgggaaa gtgatgcaga aattacaggc     4440

tcgagcgaaa gagttgatgt gcggcttgat gatgatggaa acttccagct catgaatgat     4500

ccaggagcac cttggaagat atggatgctc agaatggtct gtctcgcgat tagtgcgtac     4560

accccctggg caatcttgcc ctcagtagtt ggattttgga taactctcca atacacaaag     4620

agaggaggcg tgttgtggga cactccctca ccaaaggagt acaaaaaggg ggacacgacc     4680

accggcgtct acaggatcat gactcgtggg ctgctcggca gttatcaagc aggagcgggc     4740

gtgatggttg aaggtgtttt ccacaccctt tggcatacaa caaaaggagc cgctttgatg     4800

agcggagagg gccgcctgga cccatactgg ggcagtgtca aggaggatcg actttgttac     4860

ggaggaccct ggaaattgca gcacaagtgg aacgggcagg atgaggtgca gatgattgtg     4920

gtggaacctg gcaggaacgt taagaacgtc cagacgaaac caggggtgtt caaaacacct     4980

gaaggagaaa tcggggccgt gactttggac ttccccactg gaacatcagg ctcaccaata     5040

gtggacaaaa acggtgatgt gattgggctt tatggcaatg gagtcataat gcccaacggc     5100

tcatacataa gcgcgatagt gcagggtgaa aggatggatg agccaatccc agccggattc     5160

gaacctgaga tgctgaggaa aaaacagatc actgtactgg atctccatcc cggcgccggt     5220

aaaacaagga ggattctgcc acagatcatc aaagaggcca taaacagaag actgagaaca     5280

gccgtgctag caccaaccag ggttgtggct gctgagatgg ctgaagcact gagaggactg     5340

cccatccggt accagacatc cgcagtgccc agagaacata atggaaatga gattgttgat     5400

gtcatgtgtc atgctaccct cacccacagg ctgatgtctc ctcacagggt gccgaactac     5460

aacctgttcg tgatggatga ggctcatttc accgacccag ctagcattgc agcaagaggt     5520

tacatttcca caaaggtcga gctaggggag gcggcggcaa tattcatgac agccacccca     5580

ccaggcactt cagatccatt cccagagtcc aattcaccaa tttccgactt acagactgag     5640

atcccggatc gagcttggaa ctctggatac gaatggatca cagaatacac cgggaagacg     5700

gtttggtttg tgcctagtgt caagatgggg aatgagattg ccctttgcct acaacgtgct     5760

ggaaagaaag tagtccaatt gaacagaaag tcgtacgaga cggagtaccc aaaatgtaag     5820

aacgatgatt gggactttgt tatcacaaca gacatatctg aaatgggggc taacttcaag     5880

gcgagcaggg tgattgacag ccggaagagt gtgaaaccaa ccatcataac agaaggagaa     5940

gggagagtga tcctgggaga accatctgca gtgacagcag ctagtgccgc ccagagacgt     6000

ggacgtatcg gtagaaatcc gtcgcaagtt ggtgatgagt actgttatgg ggggcacacg     6060

aatgaagacg actcgaactt cgcccattgg actgaggcac gaatcatgct ggacaacatc     6120

aacatgccaa acggactgat cgctcaattc taccaaccag agcgtgagaa ggtatatacc     6180

atggatgggg aataccggct cagaggagaa gagagaaaaa actttctgga actgttgagg     6240

actgcagatc tgccagtttg gctggcttac aaggttgcag cggctggagt gtcataccac     6300

gaccggaggt ggtgctttga tggtcctagg acaaacacaa ttttagaaga caacaacgaa     6360

gtggaagtca tcacgaagct tggtgaaagg aagattctga ggccgcgctg gattgacgcc     6420

agggtgtact cggatcacca ggcactaaag gcgttcaagg acttcgcctc gggaaaacgt     6480

tctcagatag ggctcattga ggttctggga aagatgcctg agcacttcat ggggaagaca     6540

tgggaagcac ttgacaccat gtacgttgtg gccactgcag agaaaggagg aagagctcac     6600

agaatggccc tggaggaact gccagatgct cttcagacaa ttgccttgat tgccttattg     6660

agtgtgatga ccatgggagt attcttcctc ctcatgcagc ggaagggcat tggaaagata     6720

ggtttgggag gcgctgtctt gggagtcgcg acctttttct gttggatggc tgaagttcca     6780

ggaacgaaga tcgccggaat gttgctgctc tcccttctct tgatgattgt gctaattcct     6840

gagccagaga agcaacgttc gcagacagac aaccagctag ccgtgttcct gatttgtgtc     6900

atgacccttg tgagcgcagt ggcagccaac gagatgggtt ggctagataa gaccaagagt     6960

gacataagca gtttgtttgg gcaaagaatt gaggtcaagg agaatttcag catgggagag     7020

tttcttttgg acttgaggcc tgcaacagcc tggtcactgt acgctgtgac aacagcggtc     7080

ctcactccac tgctaaagca tttgatcacg tcagattaca tcaacacctc attgacctca     7140

ataaacgttc aggcaagtgc actattcaca ctcgcgcgag gcttcccctt cgtcgatgtt     7200

ggagtgtcgg ctctcctgct agcagccgga tgctggggac aagtcaccct caccgttacg     7260

gtaacagcgg caacactcct tttttgccac tatgcctaca tggttcccgg ttggcaagct     7320

gaggcaatgc gctcagccca gcggcggaca gcggccggaa tcatgaagaa cgctgtagtg     7380

gatggcatcg tggccacgga cgtcccagaa ttagagcgca ccacacccat catgcagaag     7440

aaagttggac agatcatgct gatcttggtg tctctagctg cagtagtagt gaacccgtct     7500

gtgaagacag tacgagaagc cggaattttg atcacggccg cagcggtgac gctttgggag     7560

aatggagcaa gctctgtttg gaacgcaaca actgccatcg gactctgcca catcatgcgt     7620

gggggttggt tgtcatgtct atccataaca tggacactca taaagaacat ggaaaaacca     7680

ggactaaaaa gaggtggggc aaaaggacgc accttgggag aggtttggaa agaaagactc     7740

aaccagatga caaaagaaga gttcactagg taccgcaaag aggccatcat cgaagtcgat     7800

cgctcagcgg caaaacacgc caggaaagaa ggcaatgtca ctggagggca tccagtctct     7860

aggggcacag caaaactgag atggctggtc gaacggaggt ttctcgaacc ggtcggaaaa     7920

gtgattgacc ttggatgtgg aagaggcggt tggtgttact atatggcaac ccaaaaaaga     7980

gtccaagaag tcagagggta cacaaagggc ggtcccggac atgaagagcc ccaactagtg     8040

caaagttatg gatggaacat tgtcaccatg aagagtggag tggatgtgtt ctacagacct     8100

tctgagtgtt gtgacaccct cctttgtgac atcggagagt cctcgtcaag tgctgaggtt     8160

gaagagcata ggacgattcg ggtccttgaa atggttgagg actggctgca ccgagggcca     8220

agggaatttt gcgtgaaggt gctctgcccc tacatgccga aagtcataga gaagatggag     8280

ctgctccaac gccggtatgg ggggggactg gtcagaaacc cactctcacg gaattccacg     8340

cacgagatgt attgggtgag tcgagcttca ggcaatgtgg tacattcagt gaatatgacc     8400

agccaggtgc tcctaggaag aatggaaaaa aggacctgga agggacccca atacgaggaa     8460

gatgtaaact tgggaagtgg aaccagggcg gtgggaaaac ccctgctcaa ctcagacacc     8520

agtaaaatca agaacaggat tgaacgactc aggcgtgagt acagttcgac gtggcaccac     8580

gatgagaacc acccatatag aacctggaac tatcacggca gttatgatgt gaagcccaca     8640

ggctccgcca gttcgctggt caatggagtg gtcaggctcc tctcaaaacc atgggacacc     8700

atcacgaatg ttaccaccat ggccatgact gacactactc ccttcgggca gcagcgagtg     8760

ttcaaagaga aggtggacac gaaagctcct gaaccgccag aaggagtgaa gtacgtgctc     8820

aacgagacca ccaactggtt gtgggcgttt ttggccagag aaaaacgtcc cagaatgtgc     8880

tctcgagagg aattcataag aaaggtcaac agcaatgcag ctttgggtgc catgtttgaa     8940

gagcagaatc aatggaggag cgccagagaa gcagttgaag atccaaaatt ttgggagatg     9000

gtggatgagg agcgcgaggc acatctgcgg ggggaatgtc acacttgcat ttacaacatg     9060

atgggaaaga gagagaaaaa acccggagag ttcggaaagg ccaagggaag cagagccatt     9120

tggttcatgt ggctcggagc tcgctttctg gagttcgagg ctctgggttt tctcaatgaa     9180

gaccactggc ttggaagaaa gaactcagga ggaggtgtcg agggcttggg cctccaaaaa     9240

ctgggttaca tcctgcgtga agttggcacc cggcctgggg gcaagatcta tgctgatgac     9300

acagctggct gggacacccg catcacgaga gctgacttgg aaaatgaagc taaggtgctt     9360

gagctgcttg atggggaaca tcggcgtctt gccagggcca tcattgagct cacctatcgt     9420

cacaaagttg tgaaagtgat gcgcccggct gctgatggaa gaaccgtcat ggatgttatc     9480

tccagagaag atcagagggg gagtggacaa gttgtcacct acgccctaaa cactttcacc     9540

aacctggccg tccagctggt gaggatgatg gaaggggaag gagtgattgg cccagatgat     9600

gtggagaaac tcacaaaagg gaaaggaccc aaagtcagga cctggctgtt tgagaatggg     9660

gaagaaagac tcagccgcat ggctgtcagt ggagatgact gtgtggtaaa gcccctggac     9720

gatcgctttg ccacctcgct ccacttcctc aatgctatgt caaaggttcg caaagacatc     9780

caagagtgga aaccgtcaac tggatggtat gattggcagc aggttccatt ttgctcaaac     9840

catttcactg aattgatcat gaaagatgga agaacactgg tggttccatg ccgaggacag     9900

gatgaattgg taggcagagc tcgcatatct ccaggggccg gatggaacgt ccgcgacact     9960

gcttgtctgg ctaagtctta tgcccagatg tggctgcttc tgtacttcca cagaagagac    10020

ctgcggctca tggccaacgc catttgctcc gctgtccctg tgaattgggt ccctaccgga    10080

agaaccacgt ggtccatcca tgcaggagga gagtggatga caacagagga catgttggag    10140

gtctggaacc gtgtttggat agaggagaat gaatggatgg aagacaaaac cccagtggag    10200

aaatggagtg acgtcccata ttcaggaaaa cgagaggaca tctggtgtgg cagcctgatt    10260

ggcacaagag cccgagccac gtgggcagaa aacatccagg tggctatcaa ccaagtcaga    10320

gcaatcatcg gagatgagaa gtatgtggat tacatgagtt cactaaagag atatgaagac    10380

acaactttgg ttgaggacac agtactgtag atatttaatc aattgtaaat agacaatata    10440

agtatgcata aaagtgtagt tttatagtag tatttagtgg tgttagtgta aatagttaag    10500

aaaattttga ggagaaagtc aggccgggaa gttcccgcca ccggaagttg agtagacggt    10560

gctgcctgcg actcaacccc aggaggactg ggtgaacaaa gccgcgaagt gatccatgta    10620

agccctcaga accgtctcgg aaggaggacc ccacatgttg taacttcaaa gcccaatgtc    10680

agaccacgct acggcgtgct actctgcgga gagtgcagtc tgcgatagtg ccccaggagg    10740

actgggttaa caaaggcaaa ccaacgcccc acgcggccct agccccggta atggtgttaa    10800

ccagggcgaa aggactagag gttagaggag accccgcggt ttaaagtgca cggcccagcc    10860

tggctgaagc tgtaggtcag gggaaggact agaggttagt ggagaccccg tgccacaaaa    10920

caccacaaca aaacagcata ttgacacctg ggatagacta ggagatcttc tgctctgcac    10980

aaccagccac acggcacagt gcgccgacaa tggtggctgg tggtgcgaga acacaggatc    11040

t                                                                    11041


<210>  2
<211>  3437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala 
            100                 105                 110         


Val Met Ile Gly Leu Ile Ala Ser Ala Met Ala Ala Glu Val Thr Arg 
        115                 120                 125             


Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu 
    130                 135                 140                 


Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln 
145                 150                 155                 160 


Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys 
                165                 170                 175     


Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys 
            180                 185                 190         


Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys 
        195                 200                 205             


Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser 
    210                 215                 220                 


Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu 
225                 230                 235                 240 


Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro 
                245                 250                 255     


Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser 
            260                 265                 270         


Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro 
        275                 280                 285             


Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu 
    290                 295                 300                 


Gly Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly 
305                 310                 315                 320 


Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu 
                325                 330                 335     


Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr 
            340                 345                 350         


Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln 
        355                 360                 365             


Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys 
    370                 375                 380                 


Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly 
385                 390                 395                 400 


Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met 
                405                 410                 415     


Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu 
            420                 425                 430         


Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly 
        435                 440                 445             


His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser 
    450                 455                 460                 


Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp 
465                 470                 475                 480 


Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr 
                485                 490                 495     


Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile 
            500                 505                 510         


Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn 
        515                 520                 525             


Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln 
    530                 535                 540                 


Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu 
545                 550                 555                 560 


Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser 
                565                 570                 575     


Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys 
            580                 585                 590         


Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile 
        595                 600                 605             


Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala 
    610                 615                 620                 


Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met 
625                 630                 635                 640 


Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile 
                645                 650                 655     


Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro 
            660                 665                 670         


Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr 
        675                 680                 685             


His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala 
    690                 695                 700                 


Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp 
705                 710                 715                 720 


Asp Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile 
                725                 730                 735     


His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser 
            740                 745                 750         


Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu 
        755                 760                 765             


Asn Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly 
    770                 775                 780                 


Val Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Ser Gly Cys Ala 
785                 790                 795                 800 


Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile 
                805                 810                 815     


His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu 
            820                 825                 830         


Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly 
        835                 840                 845             


Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp Glu 
    850                 855                 860                 


Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp 
865                 870                 875                 880 


Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro 
                885                 890                 895     


Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala 
            900                 905                 910         


Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe 
        915                 920                 925             


Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala 
    930                 935                 940                 


Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr 
945                 950                 955                 960 


Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser 
                965                 970                 975     


Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp 
            980                 985                 990         


Leu Ser Tyr Trp Ile Glu Ser Arg  Leu Asn Asp Thr Trp  Lys Leu Glu 
        995                 1000                 1005             


Arg Ala  Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
    1010                 1015                 1020             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1025                 1030                 1035             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1040                 1045                 1050             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1055                 1060                 1065             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1070                 1075                 1080             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1085                 1090                 1095             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1100                 1105                 1110             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1115                 1120                 1125             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1130                 1135                 1140             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1145                 1150                 1155             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1160                 1165                 1170             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1175                 1180                 1185             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1190                 1195                 1200             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1205                 1210                 1215             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1220                 1225                 1230             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1235                 1240                 1245             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1250                 1255                 1260             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1265                 1270                 1275             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1280                 1285                 1290             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1295                 1300                 1305             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1310                 1315                 1320             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1325                 1330                 1335             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1340                 1345                 1350             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1355                 1360                 1365             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1370                 1375                 1380             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1385                 1390                 1395             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1400                 1405                 1410             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1415                 1420                 1425             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1430                 1435                 1440             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1445                 1450                 1455             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1460                 1465                 1470             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1475                 1480                 1485             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1490                 1495                 1500             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1505                 1510                 1515             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1520                 1525                 1530             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1535                 1540                 1545             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1550                 1555                 1560             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1565                 1570                 1575             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1580                 1585                 1590             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1595                 1600                 1605             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1610                 1615                 1620             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1625                 1630                 1635             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1640                 1645                 1650             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1655                 1660                 1665             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1670                 1675                 1680             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1685                 1690                 1695             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1700                 1705                 1710             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1715                 1720                 1725             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1730                 1735                 1740             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1745                 1750                 1755             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1760                 1765                 1770             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1775                 1780                 1785             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1790                 1795                 1800             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1805                 1810                 1815             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1820                 1825                 1830             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1835                 1840                 1845             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1850                 1855                 1860             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1865                 1870                 1875             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1880                 1885                 1890             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1895                 1900                 1905             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1910                 1915                 1920             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1925                 1930                 1935             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1940                 1945                 1950             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1955                 1960                 1965             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1970                 1975                 1980             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1985                 1990                 1995             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    2000                 2005                 2010             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2015                 2020                 2025             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2030                 2035                 2040             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2045                 2050                 2055             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2060                 2065                 2070             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2075                 2080                 2085             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2090                 2095                 2100             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2105                 2110                 2115             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2120                 2125                 2130             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2135                 2140                 2145             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2150                 2155                 2160             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2165                 2170                 2175             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2180                 2185                 2190             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2210                 2215                 2220             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2225                 2230                 2235             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2240                 2245                 2250             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2255                 2260                 2265             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2270                 2275                 2280             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2285                 2290                 2295             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2300                 2305                 2310             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2315                 2320                 2325             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2330                 2335                 2340             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2345                 2350                 2355             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2360                 2365                 2370             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2375                 2380                 2385             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2390                 2395                 2400             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2405                 2410                 2415             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2420                 2425                 2430             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2435                 2440                 2445             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2450                 2455                 2460             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2465                 2470                 2475             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2480                 2485                 2490             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2495                 2500                 2505             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2510                 2515                 2520             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2525                 2530                 2535             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2540                 2545                 2550             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2555                 2560                 2565             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2570                 2575                 2580             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2585                 2590                 2595             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2600                 2605                 2610             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2615                 2620                 2625             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2630                 2635                 2640             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2645                 2650                 2655             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2660                 2665                 2670             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2675                 2680                 2685             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2690                 2695                 2700             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2705                 2710                 2715             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2720                 2725                 2730             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2735                 2740                 2745             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2750                 2755                 2760             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2765                 2770                 2775             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2780                 2785                 2790             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2795                 2800                 2805             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2810                 2815                 2820             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2825                 2830                 2835             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2840                 2845                 2850             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2855                 2860                 2865             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2870                 2875                 2880             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2885                 2890                 2895             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2900                 2905                 2910             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2915                 2920                 2925             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2930                 2935                 2940             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2945                 2950                 2955             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2960                 2965                 2970             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2975                 2980                 2985             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2990                 2995                 3000             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    3005                 3010                 3015             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3020                 3025                 3030             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3035                 3040                 3045             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3050                 3055                 3060             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3065                 3070                 3075             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3080                 3085                 3090             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3095                 3100                 3105             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3110                 3115                 3120             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3125                 3130                 3135             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3140                 3145                 3150             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3155                 3160                 3165             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3170                 3175                 3180             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3185                 3190                 3195             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3200                 3205                 3210             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3215                 3220                 3225             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3230                 3235                 3240             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3245                 3250                 3255             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3260                 3265                 3270             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3275                 3280                 3285             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3290                 3295                 3300             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3305                 3310                 3315             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3320                 3325                 3330             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3335                 3340                 3345             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3350                 3355                 3360             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3365                 3370                 3375             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3380                 3385                 3390             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3395                 3400                 3405             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3410                 3415                 3420             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3425                 3430                 3435         


<210>  3
<211>  11041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc      120

ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt      180

ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg      240

gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga      300

tggagaggtg tgaacaaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta      360

gggaccttga ccagtgctat caatcggcgg agttcgaaac aaaagaaaag aggaggaaag      420

accggaattg cagtcatgat tggcctgatc gccagcgcta tggcagcgga ggtcactaga      480

cgtgggagtg catactatat gtacttggac agaaacgatg ctggggaggc catatctttt      540

ccaaccacat tggggatgaa taagtgttat atacagatca tggatcttgg acacatgtgt      600

gatgccacca tgagctatga atgccctatg ctggatgagg gggtggaacc agatgacgtc      660

gattgttggt gcaacacgac gtcaacttgg gttgtgtacg gaacctgcca tcacaaaaaa      720

ggtgaagcac ggagaagtag aagagctgtg acgctcccct cccattccac taggaagctg      780

caaacgcggt cgcaaacctg gttggaatca agagaataca caaagcactt gattagagtc      840

gaaaattgga tattcaggaa ccctggcttc gcgttagcag cagctgccat cgcttggctt      900

ttgggaagct caacgagcca aaaagtcata tacttggtca tgatactgct gattgccccg      960

gcatacagca tcaggtgcat aggagtcagc aatagggact ttgtggaagg tatgtcaggt     1020

gggacttggg ttgatattgt cttggaacat ggaggttgtg tcaccgtaat ggcacaggac     1080

aaaccgactg tcgacataga gctggttaca acaacagtca gcaacatggc ggaggtaaga     1140

tcctactgct atgaggcatc aatatcagac atggcttcgg acagccgctg cccaacacaa     1200

ggtgaagcct accttgacaa gcaatcagac actcaatatg tctgcaaaag aacgttagtg     1260

gacagaggct ggggaaatgg atgtggactt tttggcaaag ggagtctggt gacatgcgct     1320

aagtttgcat gctccaagaa aatgaccggg aagagcatcc agccagagaa tctggagtac     1380

cggataatgc tgtcagttca tggctcccag cacagtggga tgatcgttaa tgacacagga     1440

catgaaactg atgagaatag agcgaaggtt gagataacgc ccaattcacc aagagccgaa     1500

gccaccctgg ggggttttgg aagcctagga cttgattgtg aaccgaggac aggccttgac     1560

ttttcagatt tgtattactt gactatgaat aacaagcact ggttggttca caaggagtgg     1620

ttccacgaca ttccattacc ttggcacgct ggggcagaca ccggaactcc acactggaac     1680

aacaaagaag cactggtaga gttcaaggac gcacatgcca aaaggcaaac tgtcgtggtt     1740

ctagggagtc aagaaggagc agttcacacg gcccttgctg gagctctgga ggctgagatg     1800

gatggtgcaa agggaaggct gtcctctggc cacttgaaat gtcgcctgaa aatggataaa     1860

cttagattga agggcgtgtc atactccttg tgtaccgcag cgttcacatt caccaagatc     1920

ccggctgaaa cactgcacgg gacagtcaca gtggaggtac agtacgcagg gacagatgga     1980

ccttgcaagg ttccagctca gatggcggtg gacatgcaaa ctctgacccc agttgggagg     2040

ttgataaccg ctaaccccgt aatcactgaa agcactgaga actctaagat gatgctggaa     2100

cttgatccac catttgggga ctcttacatt gtcataggag tcggggagaa gaagatcacc     2160

caccactggc acaggagtgg cagcaccatt ggaaaagcat ttgaagccac tgtgagaggt     2220

gccaagagaa tggcagtctt gggagacaca gcctgggact ttggatcagt tggaggcgct     2280

ctcaactcat tgggcaaggg catccatcaa atttttggag cagctttcaa atcattgttt     2340

ggaggaatgt cctggttctc acaaattctc attggaacgt tgctgatgtg gttgggtctg     2400

aacacaaaga atggatctat ttcccttatg tgcttggcct tagggggagt gttgatcttc     2460

ttatccacag ccgtctctgc tgattccgga tgtgccatag acatcagccg gcaagagctg     2520

agatgtggaa gtggagtgtt catacacaat gatgtggagg cttggatgga ccggtacaag     2580

tattaccctg aaacgccaca aggcctagcc aagatcattc agaaagctca taaggaagga     2640

gtgtgcggtc tacgatcagt ttccagactg gagcatcaaa tgtgggaagc agtgaaggac     2700

gagctgaaca ctcttttgaa ggagaatggt gtggacctta gtgtcgtggt tgagaaacag     2760

gagggaatgt acaagtcagc acctaaacgc ctcaccgcca ccacggaaaa attggaaatt     2820

ggctggaagg cctggggaaa gagtatttta tttgcaccag aactcgccaa caacaccttt     2880

gtggttgatg gtccggagac caaggaatgt ccgactcaga atcgcgcttg gaatagctta     2940

gaagtggagg attttggatt tggtctcacc agcactcgga tgttcctgaa ggtcagagag     3000

agcaacacaa ctgaatgtga ctcgaagatc attggaacgg ctgtcaagaa caacttggcg     3060

atccacagtg acctgtccta ttggattgaa agcaggctca atgatacgtg gaagcttgaa     3120

agggcagttc tgggtgaagt caaatcatgt acgtggcctg agacgcatac cttgtggggc     3180

gatggaatcc ttgagagtga cttgataata ccagtcacac tggcgggacc acgaagcaat     3240

cacaatcgga gacctgggta caagacacaa aaccagggcc catgggacga aggccgggta     3300

gagattgact tcgattactg cccaggaact acggtcaccc tgagtgagag ctgcggacac     3360

cgtggacctg ccactcgcac caccacagag agcggaaagt tgataacaga ttggtgctgc     3420

aggagctgca ccttaccacc actgcgctac caaactgaca gcggctgttg gtatggtatg     3480

gagatcagac cacagagaca tgatgaaaag accctcgtgc agtcacaagt gaatgcttat     3540

aatgctgata tgattgaccc ttttcagttg ggccttctgg tcgtgttctt ggccacccag     3600

gaggtccttc gcaagaggtg gacagccaag atcagcatgc cagctatact gattgctctg     3660

ctagtcctgg tgtttggggg cattacttac actgatgtgt tacgctatgt catcttggtg     3720

ggggcagctt tcgcagaatc taattcggga ggagacgtgg tacacttggc gctcatggcg     3780

accttcaaga tacaaccagt gtttatggtg gcatcgtttc tcaaagcgag atggaccaac     3840

caggagaaca ttttgttgat gttggcggct gttttctttc aaatggctta ttacgatgcc     3900

cgccaaattc tgctctggga gatccctgat gtgttgaatt cactggcggt agcttggatg     3960

atactgagag ccataacatt cacaacgaca tcaaacgtgg ttgttccgct gctagccctg     4020

ctaacacccg ggctgagatg cttgaatctg gatgtgtaca ggatactgct gttgatggtc     4080

ggaataggca gcttgatcag ggagaagagg agtgcagctg caaaaaagaa aggagcaagt     4140

ctgctatgct tggctctagc ctcaacagga cttttcaacc ccatgatcct tgctgctgga     4200

ctgattgcat gtgatcccaa ccgtaaacgc ggatggcccg caactgaagt gatgacagct     4260

gtcggcctaa tgtttgccat cgtcggaggg ctggcagagc ttgacattga ctccatggcc     4320

attccaatga ctatcgcggg gctcatgttt gctgctttcg tgatttctgg gaaatcaaca     4380

gatatgtgga ttgagagaac ggcggacatt tcctgggaaa gtgatgcaga aattacaggc     4440

tcgagcgaaa gagttgatgt gcggcttgat gatgatggaa acttccagct catgaatgat     4500

ccaggagcac cttggaagat atggatgctc agaatggtct gtctcgcgat tagtgcgtac     4560

accccctggg caatcttgcc ctcagtagtt ggattttgga taactctcca atacacaaag     4620

agaggaggcg tgttgtggga cactccctca ccaaaggagt acaaaaaggg ggacacgacc     4680

accggcgtct acaggatcat gactcgtggg ctgctcggca gttatcaagc aggagcgggc     4740

gtgatggttg aaggtgtttt ccacaccctt tggcatacaa caaaaggagc cgctttgatg     4800

agcggagagg gccgcctgga cccatactgg ggcagtgtca aggaggatcg actttgttac     4860

ggaggaccct ggaaattgca gcacaagtgg aacgggcagg atgaggtgca gatgattgtg     4920

gtggaacctg gcaggaacgt taagaacgtc cagacgaaac caggggtgtt caaaacacct     4980

gaaggagaaa tcggggccgt gactttggac ttccccactg gaacatcagg ctcaccaata     5040

gtggacaaaa acggtgatgt gattgggctt tatggcaatg gagtcataat gcccaacggc     5100

tcatacataa gcgcgatagt gcagggtgaa aggatggatg agccaatccc agccggattc     5160

gaacctgaga tgctgaggaa aaaacagatc actgtactgg atctccatcc cggcgccggt     5220

aaaacaagga ggattctgcc acagatcatc aaagaggcca taaacagaag actgagaaca     5280

gccgtgctag caccaaccag ggttgtggct gctgagatgg ctgaagcact gagaggactg     5340

cccatccggt accagacatc cgcagtgccc agagaacata atggaaatga gattgttgat     5400

gtcatgtgtc atgctaccct cacccacagg ctgatgtctc ctcacagggt gccgaactac     5460

aacctgttcg tgatggatga ggctcatttc accgacccag ctagcattgc agcaagaggt     5520

tacatttcca caaaggtcga gctaggggag gcggcggcaa tattcatgac agccacccca     5580

ccaggcactt cagatccatt cccagagtcc aattcaccaa tttccgactt acagactgag     5640

atcccggatc gagcttggaa ctctggatac gaatggatca cagaatacac cgggaagacg     5700

gtttggtttg tgcctagtgt caagatgggg aatgagattg ccctttgcct acaacgtgct     5760

ggaaagaaag tagtccaatt gaacagaaag tcgtacgaga cggagtaccc aaaatgtaag     5820

aacgatgatt gggactttgt tatcacaaca gacatatctg aaatgggggc taacttcaag     5880

gcgagcaggg tgattgacag ccggaagagt gtgaaaccaa ccatcataac agaaggagaa     5940

gggagagtga tcctgggaga accatctgca gtgacagcag ctagtgccgc ccagagacgt     6000

ggacgtatcg gtagaaatcc gtcgcaagtt ggtgatgagt actgttatgg ggggcacacg     6060

aatgaagacg actcgaactt cgcccattgg actgaggcac gaatcatgct ggacaacatc     6120

aacatgccaa acggactgat cgctcaattc taccaaccag agcgtgagaa ggtatatacc     6180

atggatgggg aataccggct cagaggagaa gagagaaaaa actttctgga actgttgagg     6240

actgcagatc tgccagtttg gctggcttac aaggttgcag cggctggagt gtcataccac     6300

gaccggaggt ggtgctttga tggtcctagg acaaacacaa ttttagaaga caacaacgaa     6360

gtggaagtca tcacgaagct tggtgaaagg aagattctga ggccgcgctg gattgacgcc     6420

agggtgtact cggatcacca ggcactaaag gcgttcaagg acttcgcctc gggaaaacgt     6480

tctcagatag ggctcattga ggttctggga aagatgcctg agcacttcat ggggaagaca     6540

tgggaagcac ttgacaccat gtacgttgtg gccactgcag agaaaggagg aagagctcac     6600

agaatggccc tggaggaact gccagatgct cttcagacaa ttgccttgat tgccttattg     6660

agtgtgatga ccatgggagt attcttcctc ctcatgcagc ggaagggcat tggaaagata     6720

ggtttgggag gcgctgtctt gggagtcgcg acctttttct gttggatggc tgaagttcca     6780

ggaacgaaga tcgccggaat gttgctgctc tcccttctct tgatgattgt gctaattcct     6840

gagccagaga agcaacgttc gcagacagac aaccagctag ccgtgttcct gatttgtgtc     6900

atgacccttg tgagcgcagt ggcagccaac gagatgggtt ggctagataa gaccaagagt     6960

gacataagca gtttgtttgg gcaaagaatt gaggtcaagg agaatttcag catgggagag     7020

tttcttttgg acttgaggcc tgcaacagcc tggtcactgt acgctgtgac aacagcggtc     7080

ctcactccac tgctaaagca tttgatcacg tcagattaca tcaacacctc attgacctca     7140

ataaacgttc aggcaagtgc actattcaca ctcgcgcgag gcttcccctt cgtcgatgtt     7200

ggagtgtcgg ctctcctgct agcagccgga tgctggggac aagtcaccct caccgttacg     7260

gtaacagcgg caacactcct tttttgccac tatgcctaca tggttcccgg ttggcaagct     7320

gaggcaatgc gctcagccca gcggcggaca gcggccggaa tcatgaagaa cgctgtagtg     7380

gatggcatcg tggccacgga cgtcccagaa ttagagcgca ccacacccat catgcagaag     7440

aaagttggac agatcatgct gatcttggtg tctctagctg cagtagtagt gaacccgtct     7500

gtgaagacag tacgagaagc cggaattttg atcacggccg cagcggtgac gctttgggag     7560

aatggagcaa gctctgtttg gaacgcaaca actgccatcg gactctgcca catcatgcgt     7620

gggggttggt tgtcatgtct atccataaca tggacactca taaagaacat ggaaaaacca     7680

ggactaaaaa gaggtggggc aaaaggacgc accttgggag aggtttggaa agaaagactc     7740

aaccagatga caaaagaaga gttcactagg taccgcaaag aggccatcat cgaagtcgat     7800

cgctcagcgg caaaacacgc caggaaagaa ggcaatgtca ctggagggca tccagtctct     7860

aggggcacag caaaactgag atggctggtc gaacggaggt ttctcgaacc ggtcggaaaa     7920

gtgattgacc ttggatgtgg aagaggcggt tggtgttact atatggcaac ccaaaaaaga     7980

gtccaagaag tcagagggta cacaaagggc ggtcccggac atgaagagcc ccaactagtg     8040

caaagttatg gatggaacat tgtcaccatg aagagtggag tggatgtgtt ctacagacct     8100

tctgagtgtt gtgacaccct cctttgtgac atcggagagt cctcgtcaag tgctgaggtt     8160

gaagagcata ggacgattcg ggtccttgaa atggttgagg actggctgca ccgagggcca     8220

agggaatttt gcgtgaaggt gctctgcccc tacatgccga aagtcataga gaagatggag     8280

ctgctccaac gccggtatgg ggggggactg gtcagaaacc cactctcacg gaattccacg     8340

cacgagatgt attgggtgag tcgagcttca ggcaatgtgg tacattcagt gaatatgacc     8400

agccaggtgc tcctaggaag aatggaaaaa aggacctgga agggacccca atacgaggaa     8460

gatgtaaact tgggaagtgg aaccagggcg gtgggaaaac ccctgctcaa ctcagacacc     8520

agtaaaatca agaacaggat tgaacgactc aggcgtgagt acagttcgac gtggcaccac     8580

gatgagaacc acccatatag aacctggaac tatcacggca gttatgatgt gaagcccaca     8640

ggctccgcca gttcgctggt caatggagtg gtcaggctcc tctcaaaacc atgggacacc     8700

atcacgaatg ttaccaccat ggccatgact gacactactc ccttcgggca gcagcgagtg     8760

ttcaaagaga aggtggacac gaaagctcct gaaccgccag aaggagtgaa gtacgtgctc     8820

aacgagacca ccaactggtt gtgggcgttt ttggccagag aaaaacgtcc cagaatgtgc     8880

tctcgagagg aattcataag aaaggtcaac agcaatgcag ctttgggtgc catgtttgaa     8940

gagcagaatc aatggaggag cgccagagaa gcagttgaag atccaaaatt ttgggagatg     9000

gtggatgagg agcgcgaggc acatctgcgg ggggaatgtc acacttgcat ttacaacatg     9060

atgggaaaga gagagaaaaa acccggagag ttcggaaagg ccaagggaag cagagccatt     9120

tggttcatgt ggctcggagc tcgctttctg gagttcgagg ctctgggttt tctcaatgaa     9180

gaccactggc ttggaagaaa gaactcagga ggaggtgtcg agggcttggg cctccaaaaa     9240

ctgggttaca tcctgcgtga agttggcacc cggcctgggg gcaagatcta tgctgatgac     9300

acagctggct gggacacccg catcacgaga gctgacttgg aaaatgaagc taaggtgctt     9360

gagctgcttg atggggaaca tcggcgtctt gccagggcca tcattgagct cacctatcgt     9420

cacaaagttg tgaaagtgat gcgcccggct gctgatggaa gaaccgtcat ggatgttatc     9480

tccagagaag atcagagggg gagtggacaa gttgtcacct acgccctaaa cactttcacc     9540

aacctggccg tccagctggt gaggatgatg gaaggggaag gagtgattgg cccagatgat     9600

gtggagaaac tcacaaaagg gaaaggaccc aaagtcagga cctggctgtt tgagaatggg     9660

gaagaaagac tcagccgcat ggctgtcagt ggagatgact gtgtggtaaa gcccctggac     9720

gatcgctttg ccacctcgct ccacttcctc aatgctatgt caaaggttcg caaagacatc     9780

caagagtgga aaccgtcaac tggatggtat gattggcagc aggttccatt ttgctcaaac     9840

catttcactg aattgatcat gaaagatgga agaacactgg tggttccatg ccgaggacag     9900

gatgaattgg taggcagagc tcgcatatct ccaggggccg gatggaacgt ccgcgacact     9960

gcttgtctgg ctaagtctta tgcccagatg tggctgcttc tgtacttcca cagaagagac    10020

ctgcggctca tggccaacgc catttgctcc gctgtccctg tgaattgggt ccctaccgga    10080

agaaccacgt ggtccatcca tgcaggagga gagtggatga caacagagga catgttggag    10140

gtctggaacc gtgtttggat agaggagaat gaatggatgg aagacaaaac cccagtggag    10200

aaatggagtg acgtcccata ttcaggaaaa cgagaggaca tctggtgtgg cagcctgatt    10260

ggcacaagag cccgagccac gtgggcagaa aacatccagg tggctatcaa ccaagtcaga    10320

gcaatcatcg gagatgagaa gtatgtggat tacatgagtt cactaaagag atatgaagac    10380

acaactttgg ttgaggacac agtactgtag atatttaatc aattgtaaat agacaatata    10440

agtatgcata aaagtgtagt tttatagtag tatttagtgg tgttagtgta aatagttaag    10500

aaaattttga ggagaaagtc aggccgggaa gttcccgcca ccggaagttg agtagacggt    10560

gctgcctgcg actcaacccc aggaggactg ggtgaacaaa gccgcgaagt gatccatgta    10620

agccctcaga accgtctcgg aaggaggacc ccacatgttg taacttcaaa gcccaatgtc    10680

agaccacgct acggcgtgct actctgcgga gagtgcagtc tgcgatagtg ccccaggagg    10740

actgggttaa caaaggcaaa ccaacgcccc acgcggccct agccccggta atggtgttaa    10800

ccagggcgaa aggactagag gttagaggag accccgcggt ttaaagtgca cggcccagcc    10860

tggctgaagc tgtaggtcag gggaaggact agaggttagt ggagaccccg tgccacaaaa    10920

caccacaaca aaacagcata ttgacacctg ggatagacta ggagatcttc tgctctgcac    10980

aaccagccac acggcacagt gcgccgacaa tggtggctgg tggtgcgaga acacaggatc    11040

t                                                                    11041


<210>  4
<211>  3437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala 
            100                 105                 110         


Val Met Ile Gly Leu Ile Ala Ser Ala Met Ala Ala Glu Val Thr Arg 
        115                 120                 125             


Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu 
    130                 135                 140                 


Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln 
145                 150                 155                 160 


Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys 
                165                 170                 175     


Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys 
            180                 185                 190         


Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys 
        195                 200                 205             


Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser 
    210                 215                 220                 


Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu 
225                 230                 235                 240 


Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro 
                245                 250                 255     


Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser 
            260                 265                 270         


Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro 
        275                 280                 285             


Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu 
    290                 295                 300                 


Gly Met Ser Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly 
305                 310                 315                 320 


Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu 
                325                 330                 335     


Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr 
            340                 345                 350         


Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln 
        355                 360                 365             


Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys 
    370                 375                 380                 


Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly 
385                 390                 395                 400 


Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met 
                405                 410                 415     


Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu 
            420                 425                 430         


Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly 
        435                 440                 445             


His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser 
    450                 455                 460                 


Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp 
465                 470                 475                 480 


Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr 
                485                 490                 495     


Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile 
            500                 505                 510         


Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn 
        515                 520                 525             


Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln 
    530                 535                 540                 


Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu 
545                 550                 555                 560 


Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser 
                565                 570                 575     


Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys 
            580                 585                 590         


Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile 
        595                 600                 605             


Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala 
    610                 615                 620                 


Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met 
625                 630                 635                 640 


Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile 
                645                 650                 655     


Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro 
            660                 665                 670         


Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr 
        675                 680                 685             


His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala 
    690                 695                 700                 


Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp 
705                 710                 715                 720 


Asp Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile 
                725                 730                 735     


His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser 
            740                 745                 750         


Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu 
        755                 760                 765             


Asn Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly 
    770                 775                 780                 


Val Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Ser Gly Cys Ala 
785                 790                 795                 800 


Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile 
                805                 810                 815     


His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu 
            820                 825                 830         


Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly 
        835                 840                 845             


Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp Glu 
    850                 855                 860                 


Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp 
865                 870                 875                 880 


Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro 
                885                 890                 895     


Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala 
            900                 905                 910         


Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe 
        915                 920                 925             


Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala 
    930                 935                 940                 


Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr 
945                 950                 955                 960 


Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser 
                965                 970                 975     


Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp 
            980                 985                 990         


Leu Ser Tyr Trp Ile Glu Ser Arg  Leu Asn Asp Thr Trp  Lys Leu Glu 
        995                 1000                 1005             


Arg Ala  Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
    1010                 1015                 1020             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1025                 1030                 1035             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1040                 1045                 1050             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1055                 1060                 1065             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1070                 1075                 1080             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1085                 1090                 1095             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1100                 1105                 1110             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1115                 1120                 1125             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1130                 1135                 1140             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1145                 1150                 1155             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1160                 1165                 1170             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1175                 1180                 1185             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1190                 1195                 1200             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1205                 1210                 1215             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1220                 1225                 1230             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1235                 1240                 1245             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1250                 1255                 1260             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1265                 1270                 1275             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1280                 1285                 1290             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1295                 1300                 1305             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1310                 1315                 1320             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1325                 1330                 1335             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1340                 1345                 1350             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1355                 1360                 1365             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1370                 1375                 1380             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1385                 1390                 1395             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1400                 1405                 1410             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1415                 1420                 1425             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1430                 1435                 1440             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1445                 1450                 1455             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1460                 1465                 1470             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1475                 1480                 1485             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1490                 1495                 1500             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1505                 1510                 1515             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1520                 1525                 1530             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1535                 1540                 1545             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1550                 1555                 1560             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1565                 1570                 1575             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1580                 1585                 1590             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1595                 1600                 1605             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1610                 1615                 1620             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1625                 1630                 1635             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1640                 1645                 1650             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1655                 1660                 1665             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1670                 1675                 1680             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1685                 1690                 1695             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1700                 1705                 1710             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1715                 1720                 1725             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1730                 1735                 1740             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1745                 1750                 1755             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1760                 1765                 1770             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1775                 1780                 1785             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1790                 1795                 1800             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1805                 1810                 1815             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1820                 1825                 1830             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1835                 1840                 1845             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1850                 1855                 1860             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1865                 1870                 1875             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1880                 1885                 1890             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1895                 1900                 1905             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1910                 1915                 1920             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1925                 1930                 1935             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1940                 1945                 1950             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1955                 1960                 1965             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1970                 1975                 1980             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1985                 1990                 1995             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    2000                 2005                 2010             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2015                 2020                 2025             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2030                 2035                 2040             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2045                 2050                 2055             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2060                 2065                 2070             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2075                 2080                 2085             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2090                 2095                 2100             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2105                 2110                 2115             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2120                 2125                 2130             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2135                 2140                 2145             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2150                 2155                 2160             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2165                 2170                 2175             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2180                 2185                 2190             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2210                 2215                 2220             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2225                 2230                 2235             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2240                 2245                 2250             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2255                 2260                 2265             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2270                 2275                 2280             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2285                 2290                 2295             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2300                 2305                 2310             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2315                 2320                 2325             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2330                 2335                 2340             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2345                 2350                 2355             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2360                 2365                 2370             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2375                 2380                 2385             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2390                 2395                 2400             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2405                 2410                 2415             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2420                 2425                 2430             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2435                 2440                 2445             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2450                 2455                 2460             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2465                 2470                 2475             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2480                 2485                 2490             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2495                 2500                 2505             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2510                 2515                 2520             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2525                 2530                 2535             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2540                 2545                 2550             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2555                 2560                 2565             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2570                 2575                 2580             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2585                 2590                 2595             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2600                 2605                 2610             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2615                 2620                 2625             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2630                 2635                 2640             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2645                 2650                 2655             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2660                 2665                 2670             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2675                 2680                 2685             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2690                 2695                 2700             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2705                 2710                 2715             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2720                 2725                 2730             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2735                 2740                 2745             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2750                 2755                 2760             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2765                 2770                 2775             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2780                 2785                 2790             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2795                 2800                 2805             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2810                 2815                 2820             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2825                 2830                 2835             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2840                 2845                 2850             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2855                 2860                 2865             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2870                 2875                 2880             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2885                 2890                 2895             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2900                 2905                 2910             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2915                 2920                 2925             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2930                 2935                 2940             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2945                 2950                 2955             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2960                 2965                 2970             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2975                 2980                 2985             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2990                 2995                 3000             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    3005                 3010                 3015             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3020                 3025                 3030             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3035                 3040                 3045             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3050                 3055                 3060             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3065                 3070                 3075             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3080                 3085                 3090             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3095                 3100                 3105             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3110                 3115                 3120             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3125                 3130                 3135             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3140                 3145                 3150             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3155                 3160                 3165             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3170                 3175                 3180             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3185                 3190                 3195             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3200                 3205                 3210             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3215                 3220                 3225             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3230                 3235                 3240             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3245                 3250                 3255             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3260                 3265                 3270             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3275                 3280                 3285             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3290                 3295                 3300             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3305                 3310                 3315             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3320                 3325                 3330             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3335                 3340                 3345             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3350                 3355                 3360             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3365                 3370                 3375             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3380                 3385                 3390             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3395                 3400                 3405             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3410                 3415                 3420             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3425                 3430                 3435         


<210>  5
<211>  11041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc      120

ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt      180

ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg      240

gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga      300

tggagaggtg tgaacaaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta      360

gggaccttga ccagtgctat caatcggcgg agttcgaaac aaaagaaaag aggaggaaag      420

accggaattg cagtcatgat tggcctgatc accacagcta tggcagcgga ggtcactaga      480

cgtgggagtg catactatat gtacttggac agaaacgatg ctggggaggc catatctttt      540

ccaaccacat tggggatgaa taagtgttat atacagatca tggatcttgg acacatgtgt      600

gatgccacca tgagctatga atgccctatg ctggatgagg gggtggaacc agatgacgtc      660

gattgttggt gcaacacgac gtcaacttgg gttgtgtacg gaacctgcca tcacaaaaaa      720

ggtgaagcac ggagaagtag aagagctgtg acgctcccct cccattccac taggaagctg      780

caaacgcggt cgcaaacctg gttggaatca agagaataca caaagcactt gattagagtc      840

gaaaattgga tattcaggaa ccctggcttc gcgttagcag cagctgccat cgcttggctt      900

ttgggaagct caacgagcca aaaagtcata tacttggtca tgatactgct gattgccccg      960

gcatacagca tcaggtgcat aggagtcagc aatagggact ttgtggaagg tatgtcaggt     1020

gggacttggg ttgatattgt cttggaacat ggaggttgtg tcaccgtaat ggcacaggac     1080

aaaccgactg tcgacataga gctggttaca acaacagtca gcaacatggc ggaggtaaga     1140

tcctactgct atgaggcatc aatatcagac atggcttcgg acagccgctg cccaacacaa     1200

ggtgaagcct accttgacaa gcaatcagac actcaatatg tctgcaaaag aacgttagtg     1260

gacagaggct ggggaaatgg atgtggactt tttggcaaag ggagtctggt gacatgcgct     1320

aagtttgcat gctccaagaa aatgaccggg aagagcatcc agccagagaa tctggagtac     1380

cggataatgc tgtcagttca tggctcccag cacagtggga tgatcgttaa tgacacagga     1440

catgaaactg atgagaatag agcgaaggtt gagataacgc ccaattcacc aagagccgaa     1500

gccaccctgg ggggttttgg aagcctagga cttgattgtg aaccgaggac aggccttgac     1560

ttttcagatt tgtattactt gactatgaat aacaagcact ggttggttca caaggagtgg     1620

ttccacgaca ttccattacc ttggcacgct ggggcagaca ccggaactcc acactggaac     1680

aacaaagaag cactggtaga gttcaaggac gcacatgcca aaaggcaaac tgtcgtggtt     1740

ctagggagtc aagaaggagc agttcacacg gcccttgctg gagctctgga ggctgagatg     1800

gatggtgcaa agggaaggct gtcctctggc cacttgaaat gtcgcctgaa aatggataaa     1860

cttagattga agggcgtgtc atactccttg tgtaccgcag cgttcacatt caccaagatc     1920

ccggctgaaa cactgcacgg gacagtcaca gtggaggtac agtacgcagg gacagatgga     1980

ccttgcaagg ttccagctca gatggcggtg gacatgcaaa ctctgacccc agttgggagg     2040

ttgataaccg ctaaccccgt aatcactgaa agcactgaga actctaagat gatgctggaa     2100

cttgatccac catttgggga ctcttacatt gtcataggag tcggggagaa gaagatcacc     2160

caccactggc acaggagtgg cagcaccatt ggaaaagcat ttgaagccac tgtgagaggt     2220

gccaagagaa tggcagtctt gggagacaca gcctgggact ttggatcagt tggaggcgct     2280

ctcaactcat tgggcaaggg catccatcaa atttttggag cagctttcaa atcattgttt     2340

ggaggaatgt cctggttctc acaaattctc attggaacgt tgctgatgtg gttgggtctg     2400

aacacaaaga atggatctat ttcccttatg tgcttggcct tagggggagt gttgatcttc     2460

ttatccacag ccgtctctgc tgattccgga tgtgccatag acatcagccg gcaagagctg     2520

agatgtggaa gtggagtgtt catacacaat gatgtggagg cttggatgga ccggtacaag     2580

tattaccctg aaacgccaca aggcctagcc aagatcattc agaaagctca taaggaagga     2640

gtgtgcggtc tacgatcagt ttccagactg gagcatcaaa tgtgggaagc agtgaaggac     2700

gagctgaaca ctcttttgaa ggagaatggt gtggacctta gtgtcgtggt tgagaaacag     2760

gagggaatgt acaagtcagc acctaaacgc ctcaccgcca ccacggaaaa attggaaatt     2820

ggctggaagg cctggggaaa gagtatttta tttgcaccag aactcgccaa caacaccttt     2880

gtggttgatg gtccggagac caaggaatgt ccgactcaga atcgcgcttg gaatagctta     2940

gaagtggagg attttggatt tggtctcacc agcactcgga tgttcctgaa ggtcagagag     3000

agcaacacaa ctgaatgtga ctcgaagatc attggaacgg ctgtcaagaa caacttggcg     3060

atccacagtg acctgtccta ttggattgaa agcaggctca atgatacgtg gaagcttgaa     3120

agggcagttc tgggtgaagt caaatcatgt acgtggcctg agacgcatac cttgtggggc     3180

gatggaatcc ttgagagtga cttgataata ccagtcacac tggcgggacc acgaagcaat     3240

cacaatcgga gacctgggta caagacacaa aaccagggcc catgggacga aggccgggta     3300

gagattgact tcgattactg cccaggaact acggtcaccc tgagtgagag ctgcggacac     3360

cgtggacctg ccactcgcac caccacagag agcggaaagt tgataacaga ttggtgctgc     3420

aggagctgca ccttaccacc actgcgctac caaactgaca gcggctgttg gtatggtatg     3480

gagatcagac cacagagaca tgatgaaaag accctcgtgc agtcacaagt gaatgcttat     3540

aatgctgata tgattgaccc ttttcagttg ggccttctgg tcgtgttctt ggccacccag     3600

gaggtccttc gcaagaggtg gacagccaag atcagcatgc cagctatact gattgctctg     3660

ctagtcctgg tgtttggggg cattacttac actgatgtgt tacgctatgt catcttggtg     3720

ggggcagctt tcgcagaatc taattcggga ggagacgtgg tacacttggc gctcatggcg     3780

accttcaaga tacaaccagt gtttatggtg gcatcgtttc tcaaagcgag atggaccaac     3840

caggagaaca ttttgttgat gttggcggct gttttctttc aaatggctta ttacgatgcc     3900

cgccaaattc tgctctggga gatccctgat gtgttgaatt cactggcggt agcttggatg     3960

atactgagag ccataacatt cacaacgaca tcaaacgtgg ttgttccgct gctagccctg     4020

ctaacacccg ggctgagatg cttgaatctg gatgtgtaca ggatactgct gttgatggtc     4080

ggaataggca gcttgatcag ggagaagagg agtgcagctg caaaaaagaa aggagcaagt     4140

ctgctatgct tggctctagc ctcaacagga cttttcaacc ccatgatcct tgctgctgga     4200

ctgattgcat gtgatcccaa ccgtaaacgc ggatggcccg caactgaagt gatgacagct     4260

gtcggcctaa tgtttgccat cgtcggaggg ctggcagagc ttgacattga ctccatggcc     4320

attccaatga ctatcgcggg gctcatgttt gctgctttcg tgatttctgg gaaatcaaca     4380

gatatgtgga ttgagagaac ggcggacatt tcctgggaaa gtgatgcaga aattacaggc     4440

tcgagcgaaa gagttgatgt gcggcttgat gatgatggaa acttccagct catgaatgat     4500

ccaggagcac cttggaagat atggatgctc agaatggtct gtctcgcgat tagtgcgtac     4560

accccctggg caatcttgcc ctcagtagtt ggattttgga taactctcca atacacaaag     4620

agaggaggcg tgttgtggga cactccctca ccaaaggagt acaaaaaggg ggacacgacc     4680

accggcgtct acaggatcat gactcgtggg ctgctcggca gttatcaagc aggagcgggc     4740

gtgatggttg aaggtgtttt ccacaccctt tggcatacaa caaaaggagc cgctttgatg     4800

agcggagagg gccgcctgga cccatactgg ggcagtgtca aggaggatcg actttgttac     4860

ggaggaccct ggaaattgca gcacaagtgg aacgggcagg atgaggtgca gatgattgtg     4920

gtggaacctg gcaggaacgt taagaacgtc cagacgaaac caggggtgtt caaaacacct     4980

gaaggagaaa tcggggccgt gactttggac ttccccactg gaacatcagg ctcaccaata     5040

gtggacaaaa acggtgatgt gattgggctt tatggcaatg gagtcataat gcccaacggc     5100

tcatacataa gcgcgatagt gcagggtgaa aggatggatg agccaatccc agccggattc     5160

gaacctgaga tgctgaggaa aaaacagatc actgtactgg atctccatcc cggcgccggt     5220

aaaacaagga ggattctgcc acagatcatc aaagaggcca taaacagaag actgagaaca     5280

gccgtgctag caccaaccag ggttgtggct gctgagatgg ctgaagcact gagaggactg     5340

cccatccggt accagacatc cgcagtgccc agagaacata atggaaatga gattgttgat     5400

gtcatgtgtc atgctaccct cacccacagg ctgatgtctc ctcacagggt gccgaactac     5460

aacctgttcg tgatggatga ggctcatttc accgacccag ctagcattgc agcaagaggt     5520

tacatttcca caaaggtcga gctaggggag gcggcggcaa tattcatgac agccacccca     5580

ccaggcactt cagatccatt cccagagtcc aattcaccaa tttccgactt acagactgag     5640

atcccggatc gagcttggaa ctctggatac gaatggatca cagaatacac cgggaagacg     5700

gtttggtttg tgcctagtgt caagatgggg aatgagattg ccctttgcct acaacgtgct     5760

ggaaagaaag tagtccaatt gaacagaaag tcgtacgaga cggagtaccc aaaatgtaag     5820

aacgatgatt gggactttgt tatcacaaca gacatatctg aaatgggggc taacttcaag     5880

gcgagcaggg tgattgacag ccggaagagt gtgaaaccaa ccatcataac agaaggagaa     5940

gggagagtga tcctgggaga accatctgca gtgacagcag ctagtgccgc ccagagacgt     6000

ggacgtatcg gtagaaatcc gtcgcaagtt ggtgatgagt actgttatgg ggggcacacg     6060

aatgaagacg actcgaactt cgcccattgg actgaggcac gaatcatgct ggacaacatc     6120

aacatgccaa acggactgat cgctcaattc taccaaccag agcgtgagaa ggtatatacc     6180

atggatgggg aataccggct cagaggagaa gagagaaaaa actttctgga actgttgagg     6240

actgcagatc tgccagtttg gctggcttac aaggttgcag cggctggagt gtcataccac     6300

gaccggaggt ggtgctttga tggtcctagg acaaacacaa ttttagaaga caacaacgaa     6360

gtggaagtca tcacgaagct tggtgaaagg aagattctga ggccgcgctg gattgacgcc     6420

agggtgtact cggatcacca ggcactaaag gcgttcaagg acttcgcctc gggaaaacgt     6480

tctcagatag ggctcattga ggttctggga aagatgcctg agcacttcat ggggaagaca     6540

tgggaagcac ttgacaccat gtacgttgtg gccactgcag agaaaggagg aagagctcac     6600

agaatggccc tggaggaact gccagatgct cttcagacaa ttgccttgat tgccttattg     6660

agtgtgatga ccatgggagt attcttcctc ctcatgcagc ggaagggcat tggaaagata     6720

ggtttgggag gcgctgtctt gggagtcgcg acctttttct gttggatggc tgaagttcca     6780

ggaacgaaga tcgccggaat gttgctgctc tcccttctct tgatgattgt gctaattcct     6840

gagccagaga agcaacgttc gcagacagac aaccagctag ccgtgttcct gatttgtgtc     6900

atgacccttg tgagcgcagt ggcagccaac gagatgggtt ggctagataa gaccaagagt     6960

gacataagca gtttgtttgg gcaaagaatt gaggtcaagg agaatttcag catgggagag     7020

tttcttttgg acttgaggcc tgcaacagcc tggtcactgt acgctgtgac aacagcggtc     7080

ctcactccac tgctaaagca tttgatcacg tcagattaca tcaacacctc attgacctca     7140

ataaacgttc aggcaagtgc actattcaca ctcgcgcgag gcttcccctt cgtcgatgtt     7200

ggagtgtcgg ctctcctgct agcagccgga tgctggggac aagtcaccct caccgttacg     7260

gtaacagcgg caacactcct tttttgccac tatgcctaca tggttcccgg ttggcaagct     7320

gaggcaatgc gctcagccca gcggcggaca gcggccggaa tcatgaagaa cgctgtagtg     7380

gatggcatcg tggccacgga cgtcccagaa ttagagcgca ccacacccat catgcagaag     7440

aaagttggac agatcatgct gatcttggtg tctctagctg cagtagtagt gaacccgtct     7500

gtgaagacag tacgagaagc cggaattttg atcacggccg cagcggtgac gctttgggag     7560

aatggagcaa gctctgtttg gaacgcaaca actgccatcg gactctgcca catcatgcgt     7620

gggggttggt tgtcatgtct atccataaca tggacactca taaagaacat ggaaaaacca     7680

ggactaaaaa gaggtggggc aaaaggacgc accttgggag aggtttggaa agaaagactc     7740

aaccagatga caaaagaaga gttcactagg taccgcaaag aggccatcat cgaagtcgat     7800

cgctcagcgg caaaacacgc caggaaagaa ggcaatgtca ctggagggca tccagtctct     7860

aggggcacag caaaactgag atggctggtc gaacggaggt ttctcgaacc ggtcggaaaa     7920

gtgattgacc ttggatgtgg aagaggcggt tggtgttact atatggcaac ccaaaaaaga     7980

gtccaagaag tcagagggta cacaaagggc ggtcccggac atgaagagcc ccaactagtg     8040

caaagttatg gatggaacat tgtcaccatg aagagtggag tggatgtgtt ctacagacct     8100

tctgagtgtt gtgacaccct cctttgtgac atcggagagt cctcgtcaag tgctgaggtt     8160

gaagagcata ggacgattcg ggtccttgaa atggttgagg actggctgca ccgagggcca     8220

agggaatttt gcgtgaaggt gctctgcccc tacatgccga aagtcataga gaagatggag     8280

ctgctccaac gccggtatgg ggggggactg gtcagaaacc cactctcacg gaattccacg     8340

cacgagatgt attgggtgag tcgagcttca ggcaatgtgg tacattcagt gaatatgacc     8400

agccaggtgc tcctaggaag aatggaaaaa aggacctgga agggacccca atacgaggaa     8460

gatgtaaact tgggaagtgg aaccagggcg gtgggaaaac ccctgctcaa ctcagacacc     8520

agtaaaatca agaacaggat tgaacgactc aggcgtgagt acagttcgac gtggcaccac     8580

gatgagaacc acccatatag aacctggaac tatcacggca gttatgatgt gaagcccaca     8640

ggctccgcca gttcgctggt caatggagtg gtcaggctcc tctcaaaacc atgggacacc     8700

atcacgaatg ttaccaccat ggccatgact gacactactc ccttcgggca gcagcgagtg     8760

ttcaaagaga aggtggacac gaaagctcct gaaccgccag aaggagtgaa gtacgtgctc     8820

aacgagacca ccaactggtt gtgggcgttt ttggccagag aaaaacgtcc cagaatgtgc     8880

tctcgagagg aattcataag aaaggtcaac agcaatgcag ctttgggtgc catgtttgaa     8940

gagcagaatc aatggaggag cgccagagaa gcagttgaag atccaaaatt ttgggagatg     9000

gtggatgagg agcgcgaggc acatctgcgg ggggaatgtc acacttgcat ttacaacatg     9060

atgggaaaga gagagaaaaa acccggagag ttcggaaagg ccaagggaag cagagccatt     9120

tggttcatgt ggctcggagc tcgctttctg gagttcgagg ctctgggttt tctcaatgaa     9180

gaccactggc ttggaagaaa gaactcagga ggaggtgtcg agggcttggg cctccaaaaa     9240

ctgggttaca tcctgcgtga agttggcacc cggcctgggg gcaagatcta tgctgatgac     9300

acagctggct gggacacccg catcacgaga gctgacttgg aaaatgaagc taaggtgctt     9360

gagctgcttg atggggaaca tcggcgtctt gccagggcca tcattgagct cacctatcgt     9420

cacaaagttg tgaaagtgat gcgcccggct gctgatggaa gaaccgtcat ggatgttatc     9480

tccagagaag atcagagggg gagtggacaa gttgtcacct acgccctaaa cactttcacc     9540

aacctggccg tccagctggt gaggatgatg gaaggggaag gagtgattgg cccagatgat     9600

gtggagaaac tcacaaaagg gaaaggaccc aaagtcagga cctggctgtt tgagaatggg     9660

gaagaaagac tcagccgcat ggctgtcagt ggagatgact gtgtggtaaa gcccctggac     9720

gatcgctttg ccacctcgct ccacttcctc aatgctatgt caaaggttcg caaagacatc     9780

caagagtgga aaccgtcaac tggatggtat gattggcagc aggttccatt ttgctcaaac     9840

catttcactg aattgatcat gaaagatgga agaacactgg tggttccatg ccgaggacag     9900

gatgaattgg taggcagagc tcgcatatct ccaggggccg gatggaacgt ccgcgacact     9960

gcttgtctgg ctaagtctta tgcccagatg tggctgcttc tgtacttcca cagaagagac    10020

ctgcggctca tggccaacgc catttgctcc gctgtccctg tgaattgggt ccctaccgga    10080

agaaccacgt ggtccatcca tgcaggagga gagtggatga caacagagga catgttggag    10140

gtctggaacc gtgtttggat agaggagaat gaatggatgg aagacaaaac cccagtggag    10200

aaatggagtg acgtcccata ttcaggaaaa cgagaggaca tctggtgtgg cagcctgatt    10260

ggcacaagag cccgagccac gtgggcagaa aacatccagg tggctatcaa ccaagtcaga    10320

gcaatcatcg gagatgagaa gtatgtggat tacatgagtt cactaaagag atatgaagac    10380

acaactttgg ttgaggacac agtactgtag atatttaatc aattgtaaat agacaatata    10440

agtatgcata aaagtgtagt tttatagtag tatttagtgg tgttagtgta aatagttaag    10500

aaaattttga ggagaaagtc aggccgggaa gttcccgcca ccggaagttg agtagacggt    10560

gctgcctgcg actcaacccc aggaggactg ggtgaacaaa gccgcgaagt gatccatgta    10620

agccctcaga accgtctcgg aaggaggacc ccacatgttg taacttcaaa gcccaatgtc    10680

agaccacgct acggcgtgct actctgcgga gagtgcagtc tgcgatagtg ccccaggagg    10740

actgggttaa caaaggcaaa ccaacgcccc acgcggccct agccccggta atggtgttaa    10800

ccagggcgaa aggactagag gttagaggag accccgcggt ttaaagtgca cggcccagcc    10860

tggctgaagc tgtaggtcag gggaaggact agaggttagt ggagaccccg tgccacaaaa    10920

caccacaaca aaacagcata ttgacacctg ggatagacta ggagatcttc tgctctgcac    10980

aaccagccac acggcacagt gcgccgacaa tggtggctgg tggtgcgaga acacaggatc    11040

t                                                                    11041


<210>  6
<211>  3437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala 
            100                 105                 110         


Val Met Ile Gly Leu Ile Thr Thr Ala Met Ala Ala Glu Val Thr Arg 
        115                 120                 125             


Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu 
    130                 135                 140                 


Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln 
145                 150                 155                 160 


Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys 
                165                 170                 175     


Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys 
            180                 185                 190         


Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys 
        195                 200                 205             


Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser 
    210                 215                 220                 


Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu 
225                 230                 235                 240 


Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro 
                245                 250                 255     


Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser 
            260                 265                 270         


Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro 
        275                 280                 285             


Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu 
    290                 295                 300                 


Gly Met Ser Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly 
305                 310                 315                 320 


Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu 
                325                 330                 335     


Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr 
            340                 345                 350         


Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln 
        355                 360                 365             


Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys 
    370                 375                 380                 


Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly 
385                 390                 395                 400 


Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met 
                405                 410                 415     


Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu 
            420                 425                 430         


Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly 
        435                 440                 445             


His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser 
    450                 455                 460                 


Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp 
465                 470                 475                 480 


Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr 
                485                 490                 495     


Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile 
            500                 505                 510         


Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn 
        515                 520                 525             


Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln 
    530                 535                 540                 


Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu 
545                 550                 555                 560 


Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser 
                565                 570                 575     


Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys 
            580                 585                 590         


Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile 
        595                 600                 605             


Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala 
    610                 615                 620                 


Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met 
625                 630                 635                 640 


Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile 
                645                 650                 655     


Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro 
            660                 665                 670         


Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr 
        675                 680                 685             


His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala 
    690                 695                 700                 


Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp 
705                 710                 715                 720 


Asp Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile 
                725                 730                 735     


His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser 
            740                 745                 750         


Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu 
        755                 760                 765             


Asn Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly 
    770                 775                 780                 


Val Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Ser Gly Cys Ala 
785                 790                 795                 800 


Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile 
                805                 810                 815     


His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu 
            820                 825                 830         


Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly 
        835                 840                 845             


Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp Glu 
    850                 855                 860                 


Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp 
865                 870                 875                 880 


Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro 
                885                 890                 895     


Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala 
            900                 905                 910         


Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe 
        915                 920                 925             


Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala 
    930                 935                 940                 


Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr 
945                 950                 955                 960 


Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser 
                965                 970                 975     


Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp 
            980                 985                 990         


Leu Ser Tyr Trp Ile Glu Ser Arg  Leu Asn Asp Thr Trp  Lys Leu Glu 
        995                 1000                 1005             


Arg Ala  Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
    1010                 1015                 1020             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1025                 1030                 1035             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1040                 1045                 1050             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1055                 1060                 1065             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1070                 1075                 1080             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1085                 1090                 1095             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1100                 1105                 1110             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1115                 1120                 1125             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1130                 1135                 1140             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1145                 1150                 1155             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1160                 1165                 1170             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1175                 1180                 1185             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1190                 1195                 1200             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1205                 1210                 1215             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1220                 1225                 1230             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1235                 1240                 1245             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1250                 1255                 1260             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1265                 1270                 1275             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1280                 1285                 1290             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1295                 1300                 1305             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1310                 1315                 1320             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1325                 1330                 1335             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1340                 1345                 1350             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1355                 1360                 1365             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1370                 1375                 1380             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1385                 1390                 1395             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1400                 1405                 1410             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1415                 1420                 1425             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1430                 1435                 1440             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1445                 1450                 1455             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1460                 1465                 1470             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1475                 1480                 1485             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1490                 1495                 1500             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1505                 1510                 1515             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1520                 1525                 1530             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1535                 1540                 1545             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1550                 1555                 1560             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1565                 1570                 1575             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1580                 1585                 1590             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1595                 1600                 1605             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1610                 1615                 1620             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1625                 1630                 1635             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1640                 1645                 1650             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1655                 1660                 1665             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1670                 1675                 1680             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1685                 1690                 1695             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1700                 1705                 1710             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1715                 1720                 1725             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1730                 1735                 1740             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1745                 1750                 1755             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1760                 1765                 1770             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1775                 1780                 1785             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1790                 1795                 1800             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1805                 1810                 1815             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1820                 1825                 1830             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1835                 1840                 1845             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1850                 1855                 1860             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1865                 1870                 1875             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1880                 1885                 1890             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1895                 1900                 1905             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1910                 1915                 1920             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1925                 1930                 1935             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1940                 1945                 1950             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1955                 1960                 1965             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1970                 1975                 1980             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1985                 1990                 1995             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    2000                 2005                 2010             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2015                 2020                 2025             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2030                 2035                 2040             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2045                 2050                 2055             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2060                 2065                 2070             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2075                 2080                 2085             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2090                 2095                 2100             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2105                 2110                 2115             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2120                 2125                 2130             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2135                 2140                 2145             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2150                 2155                 2160             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2165                 2170                 2175             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2180                 2185                 2190             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2210                 2215                 2220             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2225                 2230                 2235             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2240                 2245                 2250             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2255                 2260                 2265             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2270                 2275                 2280             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2285                 2290                 2295             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2300                 2305                 2310             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2315                 2320                 2325             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2330                 2335                 2340             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2345                 2350                 2355             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2360                 2365                 2370             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2375                 2380                 2385             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2390                 2395                 2400             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2405                 2410                 2415             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2420                 2425                 2430             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2435                 2440                 2445             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2450                 2455                 2460             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2465                 2470                 2475             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2480                 2485                 2490             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2495                 2500                 2505             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2510                 2515                 2520             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2525                 2530                 2535             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2540                 2545                 2550             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2555                 2560                 2565             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2570                 2575                 2580             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2585                 2590                 2595             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2600                 2605                 2610             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2615                 2620                 2625             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2630                 2635                 2640             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2645                 2650                 2655             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2660                 2665                 2670             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2675                 2680                 2685             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2690                 2695                 2700             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2705                 2710                 2715             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2720                 2725                 2730             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2735                 2740                 2745             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2750                 2755                 2760             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2765                 2770                 2775             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2780                 2785                 2790             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2795                 2800                 2805             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2810                 2815                 2820             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2825                 2830                 2835             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2840                 2845                 2850             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2855                 2860                 2865             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2870                 2875                 2880             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2885                 2890                 2895             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2900                 2905                 2910             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2915                 2920                 2925             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2930                 2935                 2940             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2945                 2950                 2955             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2960                 2965                 2970             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2975                 2980                 2985             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2990                 2995                 3000             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    3005                 3010                 3015             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3020                 3025                 3030             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3035                 3040                 3045             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3050                 3055                 3060             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3065                 3070                 3075             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3080                 3085                 3090             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3095                 3100                 3105             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3110                 3115                 3120             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3125                 3130                 3135             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3140                 3145                 3150             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3155                 3160                 3165             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3170                 3175                 3180             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3185                 3190                 3195             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3200                 3205                 3210             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3215                 3220                 3225             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3230                 3235                 3240             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3245                 3250                 3255             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3260                 3265                 3270             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3275                 3280                 3285             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3290                 3295                 3300             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3305                 3310                 3315             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3320                 3325                 3330             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3335                 3340                 3345             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3350                 3355                 3360             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3365                 3370                 3375             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3380                 3385                 3390             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3395                 3400                 3405             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3410                 3415                 3420             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3425                 3430                 3435         


<210>  7
<211>  11041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc      120

ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt      180

ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg      240

gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga      300

tggagaggtg tgaacaaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta      360

gggaccttga ccagtgctat caatcggcgg agttcgaaac aaaagaaaag aggaggaaag      420

actagtgtcg gaattgttgg cctcctgctg accacagcta tggcagcgga ggtcactaga      480

cgtgggagtg catactatat gtacttggac agaaacgatg ctggggaggc catatctttt      540

ccaaccacat tggggatgaa taagtgttat atacagatca tggatcttgg acacatgtgt      600

gatgccacca tgagctatga atgccctatg ctggatgagg gggtggaacc agatgacgtc      660

gattgttggt gcaacacgac gtcaacttgg gttgtgtacg gaacctgcca tcacaaaaaa      720

ggtgaagcac ggagaagtag aagagctgtg acgctcccct cccattccac taggaagctg      780

caaacgcggt cgcaaacctg gttggaatca agagaataca caaagcactt gattagagtc      840

gaaaattgga tattcaggaa ccctggcttc gcgttagcag cagctgccat cgcttggctt      900

ttgggaagct caacgagcca aaaagtcata tacttggtca tgatactgct gattgccccg      960

gcatacagca tcaggtgcat aggagtcagc aatagggact ttgtggaagg tatgtcaggt     1020

gggacttggg ttgatattgt cttggaacat ggaggttgtg tcaccgtaat ggcacaggac     1080

aaaccgactg tcgacataga gctggttaca acaacagtca gcaacatggc ggaggtaaga     1140

tcctactgct atgaggcatc aatatcagac atggcttcgg acagccgctg cccaacacaa     1200

ggtgaagcct accttgacaa gcaatcagac actcaatatg tctgcaaaag aacgttagtg     1260

gacagaggct ggggaaatgg atgtggactt tttggcaaag ggagtctggt gacatgcgct     1320

aagtttgcat gctccaagaa aatgaccggg aagagcatcc agccagagaa tctggagtac     1380

cggataatgc tgtcagttca tggctcccag cacagtggga tgatcgttaa tgacacagga     1440

catgaaactg atgagaatag agcgaaggtt gagataacgc ccaattcacc aagagccgaa     1500

gccaccctgg ggggttttgg aagcctagga cttgattgtg aaccgaggac aggccttgac     1560

ttttcagatt tgtattactt gactatgaat aacaagcact ggttggttca caaggagtgg     1620

ttccacgaca ttccattacc ttggcacgct ggggcagaca ccggaactcc acactggaac     1680

aacaaagaag cactggtaga gttcaaggac gcacatgcca aaaggcaaac tgtcgtggtt     1740

ctagggagtc aagaaggagc agttcacacg gcccttgctg gagctctgga ggctgagatg     1800

gatggtgcaa agggaaggct gtcctctggc cacttgaaat gtcgcctgaa aatggataaa     1860

cttagattga agggcgtgtc atactccttg tgtaccgcag cgttcacatt caccaagatc     1920

ccggctgaaa cactgcacgg gacagtcaca gtggaggtac agtacgcagg gacagatgga     1980

ccttgcaagg ttccagctca gatggcggtg gacatgcaaa ctctgacccc agttgggagg     2040

ttgataaccg ctaaccccgt aatcactgaa agcactgaga actctaagat gatgctggaa     2100

cttgatccac catttgggga ctcttacatt gtcataggag tcggggagaa gaagatcacc     2160

caccactggc acaggagtgg cagcaccatt ggaaaagcat ttgaagccac tgtgagaggt     2220

gccaagagaa tggcagtctt gggagacaca gcctgggact ttggatcagt tggaggcgct     2280

ctcaactcat tgggcaaggg catccatcaa atttttggag cagctttcaa atcattgttt     2340

ggaggaatgt cctggttctc acaaattctc attggaacgt tgctgatgtg gttgggtctg     2400

aacacaaaga atggatctat ttcccttatg tgcttggcct tagggggagt gttgatcttc     2460

ttatccacag ccgtctctgc tgattccgga tgtgccatag acatcagccg gcaagagctg     2520

agatgtggaa gtggagtgtt catacacaat gatgtggagg cttggatgga ccggtacaag     2580

tattaccctg aaacgccaca aggcctagcc aagatcattc agaaagctca taaggaagga     2640

gtgtgcggtc tacgatcagt ttccagactg gagcatcaaa tgtgggaagc agtgaaggac     2700

gagctgaaca ctcttttgaa ggagaatggt gtggacctta gtgtcgtggt tgagaaacag     2760

gagggaatgt acaagtcagc acctaaacgc ctcaccgcca ccacggaaaa attggaaatt     2820

ggctggaagg cctggggaaa gagtatttta tttgcaccag aactcgccaa caacaccttt     2880

gtggttgatg gtccggagac caaggaatgt ccgactcaga atcgcgcttg gaatagctta     2940

gaagtggagg attttggatt tggtctcacc agcactcgga tgttcctgaa ggtcagagag     3000

agcaacacaa ctgaatgtga ctcgaagatc attggaacgg ctgtcaagaa caacttggcg     3060

atccacagtg acctgtccta ttggattgaa agcaggctca atgatacgtg gaagcttgaa     3120

agggcagttc tgggtgaagt caaatcatgt acgtggcctg agacgcatac cttgtggggc     3180

gatggaatcc ttgagagtga cttgataata ccagtcacac tggcgggacc acgaagcaat     3240

cacaatcgga gacctgggta caagacacaa aaccagggcc catgggacga aggccgggta     3300

gagattgact tcgattactg cccaggaact acggtcaccc tgagtgagag ctgcggacac     3360

cgtggacctg ccactcgcac caccacagag agcggaaagt tgataacaga ttggtgctgc     3420

aggagctgca ccttaccacc actgcgctac caaactgaca gcggctgttg gtatggtatg     3480

gagatcagac cacagagaca tgatgaaaag accctcgtgc agtcacaagt gaatgcttat     3540

aatgctgata tgattgaccc ttttcagttg ggccttctgg tcgtgttctt ggccacccag     3600

gaggtccttc gcaagaggtg gacagccaag atcagcatgc cagctatact gattgctctg     3660

ctagtcctgg tgtttggggg cattacttac actgatgtgt tacgctatgt catcttggtg     3720

ggggcagctt tcgcagaatc taattcggga ggagacgtgg tacacttggc gctcatggcg     3780

accttcaaga tacaaccagt gtttatggtg gcatcgtttc tcaaagcgag atggaccaac     3840

caggagaaca ttttgttgat gttggcggct gttttctttc aaatggctta ttacgatgcc     3900

cgccaaattc tgctctggga gatccctgat gtgttgaatt cactggcggt agcttggatg     3960

atactgagag ccataacatt cacaacgaca tcaaacgtgg ttgttccgct gctagccctg     4020

ctaacacccg ggctgagatg cttgaatctg gatgtgtaca ggatactgct gttgatggtc     4080

ggaataggca gcttgatcag ggagaagagg agtgcagctg caaaaaagaa aggagcaagt     4140

ctgctatgct tggctctagc ctcaacagga cttttcaacc ccatgatcct tgctgctgga     4200

ctgattgcat gtgatcccaa ccgtaaacgc ggatggcccg caactgaagt gatgacagct     4260

gtcggcctaa tgtttgccat cgtcggaggg ctggcagagc ttgacattga ctccatggcc     4320

attccaatga ctatcgcggg gctcatgttt gctgctttcg tgatttctgg gaaatcaaca     4380

gatatgtgga ttgagagaac ggcggacatt tcctgggaaa gtgatgcaga aattacaggc     4440

tcgagcgaaa gagttgatgt gcggcttgat gatgatggaa acttccagct catgaatgat     4500

ccaggagcac cttggaagat atggatgctc agaatggtct gtctcgcgat tagtgcgtac     4560

accccctggg caatcttgcc ctcagtagtt ggattttgga taactctcca atacacaaag     4620

agaggaggcg tgttgtggga cactccctca ccaaaggagt acaaaaaggg ggacacgacc     4680

accggcgtct acaggatcat gactcgtggg ctgctcggca gttatcaagc aggagcgggc     4740

gtgatggttg aaggtgtttt ccacaccctt tggcatacaa caaaaggagc cgctttgatg     4800

agcggagagg gccgcctgga cccatactgg ggcagtgtca aggaggatcg actttgttac     4860

ggaggaccct ggaaattgca gcacaagtgg aacgggcagg atgaggtgca gatgattgtg     4920

gtggaacctg gcaggaacgt taagaacgtc cagacgaaac caggggtgtt caaaacacct     4980

gaaggagaaa tcggggccgt gactttggac ttccccactg gaacatcagg ctcaccaata     5040

gtggacaaaa acggtgatgt gattgggctt tatggcaatg gagtcataat gcccaacggc     5100

tcatacataa gcgcgatagt gcagggtgaa aggatggatg agccaatccc agccggattc     5160

gaacctgaga tgctgaggaa aaaacagatc actgtactgg atctccatcc cggcgccggt     5220

aaaacaagga ggattctgcc acagatcatc aaagaggcca taaacagaag actgagaaca     5280

gccgtgctag caccaaccag ggttgtggct gctgagatgg ctgaagcact gagaggactg     5340

cccatccggt accagacatc cgcagtgccc agagaacata atggaaatga gattgttgat     5400

gtcatgtgtc atgctaccct cacccacagg ctgatgtctc ctcacagggt gccgaactac     5460

aacctgttcg tgatggatga ggctcatttc accgacccag ctagcattgc agcaagaggt     5520

tacatttcca caaaggtcga gctaggggag gcggcggcaa tattcatgac agccacccca     5580

ccaggcactt cagatccatt cccagagtcc aattcaccaa tttccgactt acagactgag     5640

atcccggatc gagcttggaa ctctggatac gaatggatca cagaatacac cgggaagacg     5700

gtttggtttg tgcctagtgt caagatgggg aatgagattg ccctttgcct acaacgtgct     5760

ggaaagaaag tagtccaatt gaacagaaag tcgtacgaga cggagtaccc aaaatgtaag     5820

aacgatgatt gggactttgt tatcacaaca gacatatctg aaatgggggc taacttcaag     5880

gcgagcaggg tgattgacag ccggaagagt gtgaaaccaa ccatcataac agaaggagaa     5940

gggagagtga tcctgggaga accatctgca gtgacagcag ctagtgccgc ccagagacgt     6000

ggacgtatcg gtagaaatcc gtcgcaagtt ggtgatgagt actgttatgg ggggcacacg     6060

aatgaagacg actcgaactt cgcccattgg actgaggcac gaatcatgct ggacaacatc     6120

aacatgccaa acggactgat cgctcaattc taccaaccag agcgtgagaa ggtatatacc     6180

atggatgggg aataccggct cagaggagaa gagagaaaaa actttctgga actgttgagg     6240

actgcagatc tgccagtttg gctggcttac aaggttgcag cggctggagt gtcataccac     6300

gaccggaggt ggtgctttga tggtcctagg acaaacacaa ttttagaaga caacaacgaa     6360

gtggaagtca tcacgaagct tggtgaaagg aagattctga ggccgcgctg gattgacgcc     6420

agggtgtact cggatcacca ggcactaaag gcgttcaagg acttcgcctc gggaaaacgt     6480

tctcagatag ggctcattga ggttctggga aagatgcctg agcacttcat ggggaagaca     6540

tgggaagcac ttgacaccat gtacgttgtg gccactgcag agaaaggagg aagagctcac     6600

agaatggccc tggaggaact gccagatgct cttcagacaa ttgccttgat tgccttattg     6660

agtgtgatga ccatgggagt attcttcctc ctcatgcagc ggaagggcat tggaaagata     6720

ggtttgggag gcgctgtctt gggagtcgcg acctttttct gttggatggc tgaagttcca     6780

ggaacgaaga tcgccggaat gttgctgctc tcccttctct tgatgattgt gctaattcct     6840

gagccagaga agcaacgttc gcagacagac aaccagctag ccgtgttcct gatttgtgtc     6900

atgacccttg tgagcgcagt ggcagccaac gagatgggtt ggctagataa gaccaagagt     6960

gacataagca gtttgtttgg gcaaagaatt gaggtcaagg agaatttcag catgggagag     7020

tttcttttgg acttgaggcc tgcaacagcc tggtcactgt acgctgtgac aacagcggtc     7080

ctcactccac tgctaaagca tttgatcacg tcagattaca tcaacacctc attgacctca     7140

ataaacgttc aggcaagtgc actattcaca ctcgcgcgag gcttcccctt cgtcgatgtt     7200

ggagtgtcgg ctctcctgct agcagccgga tgctggggac aagtcaccct caccgttacg     7260

gtaacagcgg caacactcct tttttgccac tatgcctaca tggttcccgg ttggcaagct     7320

gaggcaatgc gctcagccca gcggcggaca gcggccggaa tcatgaagaa cgctgtagtg     7380

gatggcatcg tggccacgga cgtcccagaa ttagagcgca ccacacccat catgcagaag     7440

aaagttggac agatcatgct gatcttggtg tctctagctg cagtagtagt gaacccgtct     7500

gtgaagacag tacgagaagc cggaattttg atcacggccg cagcggtgac gctttgggag     7560

aatggagcaa gctctgtttg gaacgcaaca actgccatcg gactctgcca catcatgcgt     7620

gggggttggt tgtcatgtct atccataaca tggacactca taaagaacat ggaaaaacca     7680

ggactaaaaa gaggtggggc aaaaggacgc accttgggag aggtttggaa agaaagactc     7740

aaccagatga caaaagaaga gttcactagg taccgcaaag aggccatcat cgaagtcgat     7800

cgctcagcgg caaaacacgc caggaaagaa ggcaatgtca ctggagggca tccagtctct     7860

aggggcacag caaaactgag atggctggtc gaacggaggt ttctcgaacc ggtcggaaaa     7920

gtgattgacc ttggatgtgg aagaggcggt tggtgttact atatggcaac ccaaaaaaga     7980

gtccaagaag tcagagggta cacaaagggc ggtcccggac atgaagagcc ccaactagtg     8040

caaagttatg gatggaacat tgtcaccatg aagagtggag tggatgtgtt ctacagacct     8100

tctgagtgtt gtgacaccct cctttgtgac atcggagagt cctcgtcaag tgctgaggtt     8160

gaagagcata ggacgattcg ggtccttgaa atggttgagg actggctgca ccgagggcca     8220

agggaatttt gcgtgaaggt gctctgcccc tacatgccga aagtcataga gaagatggag     8280

ctgctccaac gccggtatgg ggggggactg gtcagaaacc cactctcacg gaattccacg     8340

cacgagatgt attgggtgag tcgagcttca ggcaatgtgg tacattcagt gaatatgacc     8400

agccaggtgc tcctaggaag aatggaaaaa aggacctgga agggacccca atacgaggaa     8460

gatgtaaact tgggaagtgg aaccagggcg gtgggaaaac ccctgctcaa ctcagacacc     8520

agtaaaatca agaacaggat tgaacgactc aggcgtgagt acagttcgac gtggcaccac     8580

gatgagaacc acccatatag aacctggaac tatcacggca gttatgatgt gaagcccaca     8640

ggctccgcca gttcgctggt caatggagtg gtcaggctcc tctcaaaacc atgggacacc     8700

atcacgaatg ttaccaccat ggccatgact gacactactc ccttcgggca gcagcgagtg     8760

ttcaaagaga aggtggacac gaaagctcct gaaccgccag aaggagtgaa gtacgtgctc     8820

aacgagacca ccaactggtt gtgggcgttt ttggccagag aaaaacgtcc cagaatgtgc     8880

tctcgagagg aattcataag aaaggtcaac agcaatgcag ctttgggtgc catgtttgaa     8940

gagcagaatc aatggaggag cgccagagaa gcagttgaag atccaaaatt ttgggagatg     9000

gtggatgagg agcgcgaggc acatctgcgg ggggaatgtc acacttgcat ttacaacatg     9060

atgggaaaga gagagaaaaa acccggagag ttcggaaagg ccaagggaag cagagccatt     9120

tggttcatgt ggctcggagc tcgctttctg gagttcgagg ctctgggttt tctcaatgaa     9180

gaccactggc ttggaagaaa gaactcagga ggaggtgtcg agggcttggg cctccaaaaa     9240

ctgggttaca tcctgcgtga agttggcacc cggcctgggg gcaagatcta tgctgatgac     9300

acagctggct gggacacccg catcacgaga gctgacttgg aaaatgaagc taaggtgctt     9360

gagctgcttg atggggaaca tcggcgtctt gccagggcca tcattgagct cacctatcgt     9420

cacaaagttg tgaaagtgat gcgcccggct gctgatggaa gaaccgtcat ggatgttatc     9480

tccagagaag atcagagggg gagtggacaa gttgtcacct acgccctaaa cactttcacc     9540

aacctggccg tccagctggt gaggatgatg gaaggggaag gagtgattgg cccagatgat     9600

gtggagaaac tcacaaaagg gaaaggaccc aaagtcagga cctggctgtt tgagaatggg     9660

gaagaaagac tcagccgcat ggctgtcagt ggagatgact gtgtggtaaa gcccctggac     9720

gatcgctttg ccacctcgct ccacttcctc aatgctatgt caaaggttcg caaagacatc     9780

caagagtgga aaccgtcaac tggatggtat gattggcagc aggttccatt ttgctcaaac     9840

catttcactg aattgatcat gaaagatgga agaacactgg tggttccatg ccgaggacag     9900

gatgaattgg taggcagagc tcgcatatct ccaggggccg gatggaacgt ccgcgacact     9960

gcttgtctgg ctaagtctta tgcccagatg tggctgcttc tgtacttcca cagaagagac    10020

ctgcggctca tggccaacgc catttgctcc gctgtccctg tgaattgggt ccctaccgga    10080

agaaccacgt ggtccatcca tgcaggagga gagtggatga caacagagga catgttggag    10140

gtctggaacc gtgtttggat agaggagaat gaatggatgg aagacaaaac cccagtggag    10200

aaatggagtg acgtcccata ttcaggaaaa cgagaggaca tctggtgtgg cagcctgatt    10260

ggcacaagag cccgagccac gtgggcagaa aacatccagg tggctatcaa ccaagtcaga    10320

gcaatcatcg gagatgagaa gtatgtggat tacatgagtt cactaaagag atatgaagac    10380

acaactttgg ttgaggacac agtactgtag atatttaatc aattgtaaat agacaatata    10440

agtatgcata aaagtgtagt tttatagtag tatttagtgg tgttagtgta aatagttaag    10500

aaaattttga ggagaaagtc aggccgggaa gttcccgcca ccggaagttg agtagacggt    10560

gctgcctgcg actcaacccc aggaggactg ggtgaacaaa gccgcgaagt gatccatgta    10620

agccctcaga accgtctcgg aaggaggacc ccacatgttg taacttcaaa gcccaatgtc    10680

agaccacgct acggcgtgct actctgcgga gagtgcagtc tgcgatagtg ccccaggagg    10740

actgggttaa caaaggcaaa ccaacgcccc acgcggccct agccccggta atggtgttaa    10800

ccagggcgaa aggactagag gttagaggag accccgcggt ttaaagtgca cggcccagcc    10860

tggctgaagc tgtaggtcag gggaaggact agaggttagt ggagaccccg tgccacaaaa    10920

caccacaaca aaacagcata ttgacacctg ggatagacta ggagatcttc tgctctgcac    10980

aaccagccac acggcacagt gcgccgacaa tggtggctgg tggtgcgaga acacaggatc    11040

t                                                                    11041


<210>  8
<211>  3437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Ser Val Gly 
            100                 105                 110         


Ile Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg 
        115                 120                 125             


Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu 
    130                 135                 140                 


Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln 
145                 150                 155                 160 


Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys 
                165                 170                 175     


Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys 
            180                 185                 190         


Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys 
        195                 200                 205             


Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser 
    210                 215                 220                 


Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu 
225                 230                 235                 240 


Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro 
                245                 250                 255     


Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser 
            260                 265                 270         


Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro 
        275                 280                 285             


Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu 
    290                 295                 300                 


Gly Met Ser Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly 
305                 310                 315                 320 


Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu 
                325                 330                 335     


Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr 
            340                 345                 350         


Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln 
        355                 360                 365             


Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys 
    370                 375                 380                 


Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly 
385                 390                 395                 400 


Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met 
                405                 410                 415     


Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu 
            420                 425                 430         


Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly 
        435                 440                 445             


His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser 
    450                 455                 460                 


Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp 
465                 470                 475                 480 


Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr 
                485                 490                 495     


Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile 
            500                 505                 510         


Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn 
        515                 520                 525             


Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln 
    530                 535                 540                 


Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu 
545                 550                 555                 560 


Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser 
                565                 570                 575     


Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys 
            580                 585                 590         


Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile 
        595                 600                 605             


Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala 
    610                 615                 620                 


Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met 
625                 630                 635                 640 


Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile 
                645                 650                 655     


Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro 
            660                 665                 670         


Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr 
        675                 680                 685             


His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala 
    690                 695                 700                 


Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp 
705                 710                 715                 720 


Asp Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile 
                725                 730                 735     


His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser 
            740                 745                 750         


Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu 
        755                 760                 765             


Asn Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly 
    770                 775                 780                 


Val Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Ser Gly Cys Ala 
785                 790                 795                 800 


Ile Asp Ile Ser Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile 
                805                 810                 815     


His Asn Asp Val Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu 
            820                 825                 830         


Thr Pro Gln Gly Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly 
        835                 840                 845             


Val Cys Gly Leu Arg Ser Val Ser Arg Leu Glu His Gln Met Trp Glu 
    850                 855                 860                 


Ala Val Lys Asp Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp 
865                 870                 875                 880 


Leu Ser Val Val Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro 
                885                 890                 895     


Lys Arg Leu Thr Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala 
            900                 905                 910         


Trp Gly Lys Ser Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe 
        915                 920                 925             


Val Val Asp Gly Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala 
    930                 935                 940                 


Trp Asn Ser Leu Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr 
945                 950                 955                 960 


Arg Met Phe Leu Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser 
                965                 970                 975     


Lys Ile Ile Gly Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp 
            980                 985                 990         


Leu Ser Tyr Trp Ile Glu Ser Arg  Leu Asn Asp Thr Trp  Lys Leu Glu 
        995                 1000                 1005             


Arg Ala  Val Leu Gly Glu Val  Lys Ser Cys Thr Trp  Pro Glu Thr 
    1010                 1015                 1020             


His Thr  Leu Trp Gly Asp Gly  Ile Leu Glu Ser Asp  Leu Ile Ile 
    1025                 1030                 1035             


Pro Val  Thr Leu Ala Gly Pro  Arg Ser Asn His Asn  Arg Arg Pro 
    1040                 1045                 1050             


Gly Tyr  Lys Thr Gln Asn Gln  Gly Pro Trp Asp Glu  Gly Arg Val 
    1055                 1060                 1065             


Glu Ile  Asp Phe Asp Tyr Cys  Pro Gly Thr Thr Val  Thr Leu Ser 
    1070                 1075                 1080             


Glu Ser  Cys Gly His Arg Gly  Pro Ala Thr Arg Thr  Thr Thr Glu 
    1085                 1090                 1095             


Ser Gly  Lys Leu Ile Thr Asp  Trp Cys Cys Arg Ser  Cys Thr Leu 
    1100                 1105                 1110             


Pro Pro  Leu Arg Tyr Gln Thr  Asp Ser Gly Cys Trp  Tyr Gly Met 
    1115                 1120                 1125             


Glu Ile  Arg Pro Gln Arg His  Asp Glu Lys Thr Leu  Val Gln Ser 
    1130                 1135                 1140             


Gln Val  Asn Ala Tyr Asn Ala  Asp Met Ile Asp Pro  Phe Gln Leu 
    1145                 1150                 1155             


Gly Leu  Leu Val Val Phe Leu  Ala Thr Gln Glu Val  Leu Arg Lys 
    1160                 1165                 1170             


Arg Trp  Thr Ala Lys Ile Ser  Met Pro Ala Ile Leu  Ile Ala Leu 
    1175                 1180                 1185             


Leu Val  Leu Val Phe Gly Gly  Ile Thr Tyr Thr Asp  Val Leu Arg 
    1190                 1195                 1200             


Tyr Val  Ile Leu Val Gly Ala  Ala Phe Ala Glu Ser  Asn Ser Gly 
    1205                 1210                 1215             


Gly Asp  Val Val His Leu Ala  Leu Met Ala Thr Phe  Lys Ile Gln 
    1220                 1225                 1230             


Pro Val  Phe Met Val Ala Ser  Phe Leu Lys Ala Arg  Trp Thr Asn 
    1235                 1240                 1245             


Gln Glu  Asn Ile Leu Leu Met  Leu Ala Ala Val Phe  Phe Gln Met 
    1250                 1255                 1260             


Ala Tyr  Tyr Asp Ala Arg Gln  Ile Leu Leu Trp Glu  Ile Pro Asp 
    1265                 1270                 1275             


Val Leu  Asn Ser Leu Ala Val  Ala Trp Met Ile Leu  Arg Ala Ile 
    1280                 1285                 1290             


Thr Phe  Thr Thr Thr Ser Asn  Val Val Val Pro Leu  Leu Ala Leu 
    1295                 1300                 1305             


Leu Thr  Pro Gly Leu Arg Cys  Leu Asn Leu Asp Val  Tyr Arg Ile 
    1310                 1315                 1320             


Leu Leu  Leu Met Val Gly Ile  Gly Ser Leu Ile Arg  Glu Lys Arg 
    1325                 1330                 1335             


Ser Ala  Ala Ala Lys Lys Lys  Gly Ala Ser Leu Leu  Cys Leu Ala 
    1340                 1345                 1350             


Leu Ala  Ser Thr Gly Leu Phe  Asn Pro Met Ile Leu  Ala Ala Gly 
    1355                 1360                 1365             


Leu Ile  Ala Cys Asp Pro Asn  Arg Lys Arg Gly Trp  Pro Ala Thr 
    1370                 1375                 1380             


Glu Val  Met Thr Ala Val Gly  Leu Met Phe Ala Ile  Val Gly Gly 
    1385                 1390                 1395             


Leu Ala  Glu Leu Asp Ile Asp  Ser Met Ala Ile Pro  Met Thr Ile 
    1400                 1405                 1410             


Ala Gly  Leu Met Phe Ala Ala  Phe Val Ile Ser Gly  Lys Ser Thr 
    1415                 1420                 1425             


Asp Met  Trp Ile Glu Arg Thr  Ala Asp Ile Ser Trp  Glu Ser Asp 
    1430                 1435                 1440             


Ala Glu  Ile Thr Gly Ser Ser  Glu Arg Val Asp Val  Arg Leu Asp 
    1445                 1450                 1455             


Asp Asp  Gly Asn Phe Gln Leu  Met Asn Asp Pro Gly  Ala Pro Trp 
    1460                 1465                 1470             


Lys Ile  Trp Met Leu Arg Met  Val Cys Leu Ala Ile  Ser Ala Tyr 
    1475                 1480                 1485             


Thr Pro  Trp Ala Ile Leu Pro  Ser Val Val Gly Phe  Trp Ile Thr 
    1490                 1495                 1500             


Leu Gln  Tyr Thr Lys Arg Gly  Gly Val Leu Trp Asp  Thr Pro Ser 
    1505                 1510                 1515             


Pro Lys  Glu Tyr Lys Lys Gly  Asp Thr Thr Thr Gly  Val Tyr Arg 
    1520                 1525                 1530             


Ile Met  Thr Arg Gly Leu Leu  Gly Ser Tyr Gln Ala  Gly Ala Gly 
    1535                 1540                 1545             


Val Met  Val Glu Gly Val Phe  His Thr Leu Trp His  Thr Thr Lys 
    1550                 1555                 1560             


Gly Ala  Ala Leu Met Ser Gly  Glu Gly Arg Leu Asp  Pro Tyr Trp 
    1565                 1570                 1575             


Gly Ser  Val Lys Glu Asp Arg  Leu Cys Tyr Gly Gly  Pro Trp Lys 
    1580                 1585                 1590             


Leu Gln  His Lys Trp Asn Gly  Gln Asp Glu Val Gln  Met Ile Val 
    1595                 1600                 1605             


Val Glu  Pro Gly Arg Asn Val  Lys Asn Val Gln Thr  Lys Pro Gly 
    1610                 1615                 1620             


Val Phe  Lys Thr Pro Glu Gly  Glu Ile Gly Ala Val  Thr Leu Asp 
    1625                 1630                 1635             


Phe Pro  Thr Gly Thr Ser Gly  Ser Pro Ile Val Asp  Lys Asn Gly 
    1640                 1645                 1650             


Asp Val  Ile Gly Leu Tyr Gly  Asn Gly Val Ile Met  Pro Asn Gly 
    1655                 1660                 1665             


Ser Tyr  Ile Ser Ala Ile Val  Gln Gly Glu Arg Met  Asp Glu Pro 
    1670                 1675                 1680             


Ile Pro  Ala Gly Phe Glu Pro  Glu Met Leu Arg Lys  Lys Gln Ile 
    1685                 1690                 1695             


Thr Val  Leu Asp Leu His Pro  Gly Ala Gly Lys Thr  Arg Arg Ile 
    1700                 1705                 1710             


Leu Pro  Gln Ile Ile Lys Glu  Ala Ile Asn Arg Arg  Leu Arg Thr 
    1715                 1720                 1725             


Ala Val  Leu Ala Pro Thr Arg  Val Val Ala Ala Glu  Met Ala Glu 
    1730                 1735                 1740             


Ala Leu  Arg Gly Leu Pro Ile  Arg Tyr Gln Thr Ser  Ala Val Pro 
    1745                 1750                 1755             


Arg Glu  His Asn Gly Asn Glu  Ile Val Asp Val Met  Cys His Ala 
    1760                 1765                 1770             


Thr Leu  Thr His Arg Leu Met  Ser Pro His Arg Val  Pro Asn Tyr 
    1775                 1780                 1785             


Asn Leu  Phe Val Met Asp Glu  Ala His Phe Thr Asp  Pro Ala Ser 
    1790                 1795                 1800             


Ile Ala  Ala Arg Gly Tyr Ile  Ser Thr Lys Val Glu  Leu Gly Glu 
    1805                 1810                 1815             


Ala Ala  Ala Ile Phe Met Thr  Ala Thr Pro Pro Gly  Thr Ser Asp 
    1820                 1825                 1830             


Pro Phe  Pro Glu Ser Asn Ser  Pro Ile Ser Asp Leu  Gln Thr Glu 
    1835                 1840                 1845             


Ile Pro  Asp Arg Ala Trp Asn  Ser Gly Tyr Glu Trp  Ile Thr Glu 
    1850                 1855                 1860             


Tyr Thr  Gly Lys Thr Val Trp  Phe Val Pro Ser Val  Lys Met Gly 
    1865                 1870                 1875             


Asn Glu  Ile Ala Leu Cys Leu  Gln Arg Ala Gly Lys  Lys Val Val 
    1880                 1885                 1890             


Gln Leu  Asn Arg Lys Ser Tyr  Glu Thr Glu Tyr Pro  Lys Cys Lys 
    1895                 1900                 1905             


Asn Asp  Asp Trp Asp Phe Val  Ile Thr Thr Asp Ile  Ser Glu Met 
    1910                 1915                 1920             


Gly Ala  Asn Phe Lys Ala Ser  Arg Val Ile Asp Ser  Arg Lys Ser 
    1925                 1930                 1935             


Val Lys  Pro Thr Ile Ile Thr  Glu Gly Glu Gly Arg  Val Ile Leu 
    1940                 1945                 1950             


Gly Glu  Pro Ser Ala Val Thr  Ala Ala Ser Ala Ala  Gln Arg Arg 
    1955                 1960                 1965             


Gly Arg  Ile Gly Arg Asn Pro  Ser Gln Val Gly Asp  Glu Tyr Cys 
    1970                 1975                 1980             


Tyr Gly  Gly His Thr Asn Glu  Asp Asp Ser Asn Phe  Ala His Trp 
    1985                 1990                 1995             


Thr Glu  Ala Arg Ile Met Leu  Asp Asn Ile Asn Met  Pro Asn Gly 
    2000                 2005                 2010             


Leu Ile  Ala Gln Phe Tyr Gln  Pro Glu Arg Glu Lys  Val Tyr Thr 
    2015                 2020                 2025             


Met Asp  Gly Glu Tyr Arg Leu  Arg Gly Glu Glu Arg  Lys Asn Phe 
    2030                 2035                 2040             


Leu Glu  Leu Leu Arg Thr Ala  Asp Leu Pro Val Trp  Leu Ala Tyr 
    2045                 2050                 2055             


Lys Val  Ala Ala Ala Gly Val  Ser Tyr His Asp Arg  Arg Trp Cys 
    2060                 2065                 2070             


Phe Asp  Gly Pro Arg Thr Asn  Thr Ile Leu Glu Asp  Asn Asn Glu 
    2075                 2080                 2085             


Val Glu  Val Ile Thr Lys Leu  Gly Glu Arg Lys Ile  Leu Arg Pro 
    2090                 2095                 2100             


Arg Trp  Ile Asp Ala Arg Val  Tyr Ser Asp His Gln  Ala Leu Lys 
    2105                 2110                 2115             


Ala Phe  Lys Asp Phe Ala Ser  Gly Lys Arg Ser Gln  Ile Gly Leu 
    2120                 2125                 2130             


Ile Glu  Val Leu Gly Lys Met  Pro Glu His Phe Met  Gly Lys Thr 
    2135                 2140                 2145             


Trp Glu  Ala Leu Asp Thr Met  Tyr Val Val Ala Thr  Ala Glu Lys 
    2150                 2155                 2160             


Gly Gly  Arg Ala His Arg Met  Ala Leu Glu Glu Leu  Pro Asp Ala 
    2165                 2170                 2175             


Leu Gln  Thr Ile Ala Leu Ile  Ala Leu Leu Ser Val  Met Thr Met 
    2180                 2185                 2190             


Gly Val  Phe Phe Leu Leu Met  Gln Arg Lys Gly Ile  Gly Lys Ile 
    2195                 2200                 2205             


Gly Leu  Gly Gly Ala Val Leu  Gly Val Ala Thr Phe  Phe Cys Trp 
    2210                 2215                 2220             


Met Ala  Glu Val Pro Gly Thr  Lys Ile Ala Gly Met  Leu Leu Leu 
    2225                 2230                 2235             


Ser Leu  Leu Leu Met Ile Val  Leu Ile Pro Glu Pro  Glu Lys Gln 
    2240                 2245                 2250             


Arg Ser  Gln Thr Asp Asn Gln  Leu Ala Val Phe Leu  Ile Cys Val 
    2255                 2260                 2265             


Met Thr  Leu Val Ser Ala Val  Ala Ala Asn Glu Met  Gly Trp Leu 
    2270                 2275                 2280             


Asp Lys  Thr Lys Ser Asp Ile  Ser Ser Leu Phe Gly  Gln Arg Ile 
    2285                 2290                 2295             


Glu Val  Lys Glu Asn Phe Ser  Met Gly Glu Phe Leu  Leu Asp Leu 
    2300                 2305                 2310             


Arg Pro  Ala Thr Ala Trp Ser  Leu Tyr Ala Val Thr  Thr Ala Val 
    2315                 2320                 2325             


Leu Thr  Pro Leu Leu Lys His  Leu Ile Thr Ser Asp  Tyr Ile Asn 
    2330                 2335                 2340             


Thr Ser  Leu Thr Ser Ile Asn  Val Gln Ala Ser Ala  Leu Phe Thr 
    2345                 2350                 2355             


Leu Ala  Arg Gly Phe Pro Phe  Val Asp Val Gly Val  Ser Ala Leu 
    2360                 2365                 2370             


Leu Leu  Ala Ala Gly Cys Trp  Gly Gln Val Thr Leu  Thr Val Thr 
    2375                 2380                 2385             


Val Thr  Ala Ala Thr Leu Leu  Phe Cys His Tyr Ala  Tyr Met Val 
    2390                 2395                 2400             


Pro Gly  Trp Gln Ala Glu Ala  Met Arg Ser Ala Gln  Arg Arg Thr 
    2405                 2410                 2415             


Ala Ala  Gly Ile Met Lys Asn  Ala Val Val Asp Gly  Ile Val Ala 
    2420                 2425                 2430             


Thr Asp  Val Pro Glu Leu Glu  Arg Thr Thr Pro Ile  Met Gln Lys 
    2435                 2440                 2445             


Lys Val  Gly Gln Ile Met Leu  Ile Leu Val Ser Leu  Ala Ala Val 
    2450                 2455                 2460             


Val Val  Asn Pro Ser Val Lys  Thr Val Arg Glu Ala  Gly Ile Leu 
    2465                 2470                 2475             


Ile Thr  Ala Ala Ala Val Thr  Leu Trp Glu Asn Gly  Ala Ser Ser 
    2480                 2485                 2490             


Val Trp  Asn Ala Thr Thr Ala  Ile Gly Leu Cys His  Ile Met Arg 
    2495                 2500                 2505             


Gly Gly  Trp Leu Ser Cys Leu  Ser Ile Thr Trp Thr  Leu Ile Lys 
    2510                 2515                 2520             


Asn Met  Glu Lys Pro Gly Leu  Lys Arg Gly Gly Ala  Lys Gly Arg 
    2525                 2530                 2535             


Thr Leu  Gly Glu Val Trp Lys  Glu Arg Leu Asn Gln  Met Thr Lys 
    2540                 2545                 2550             


Glu Glu  Phe Thr Arg Tyr Arg  Lys Glu Ala Ile Ile  Glu Val Asp 
    2555                 2560                 2565             


Arg Ser  Ala Ala Lys His Ala  Arg Lys Glu Gly Asn  Val Thr Gly 
    2570                 2575                 2580             


Gly His  Pro Val Ser Arg Gly  Thr Ala Lys Leu Arg  Trp Leu Val 
    2585                 2590                 2595             


Glu Arg  Arg Phe Leu Glu Pro  Val Gly Lys Val Ile  Asp Leu Gly 
    2600                 2605                 2610             


Cys Gly  Arg Gly Gly Trp Cys  Tyr Tyr Met Ala Thr  Gln Lys Arg 
    2615                 2620                 2625             


Val Gln  Glu Val Arg Gly Tyr  Thr Lys Gly Gly Pro  Gly His Glu 
    2630                 2635                 2640             


Glu Pro  Gln Leu Val Gln Ser  Tyr Gly Trp Asn Ile  Val Thr Met 
    2645                 2650                 2655             


Lys Ser  Gly Val Asp Val Phe  Tyr Arg Pro Ser Glu  Cys Cys Asp 
    2660                 2665                 2670             


Thr Leu  Leu Cys Asp Ile Gly  Glu Ser Ser Ser Ser  Ala Glu Val 
    2675                 2680                 2685             


Glu Glu  His Arg Thr Ile Arg  Val Leu Glu Met Val  Glu Asp Trp 
    2690                 2695                 2700             


Leu His  Arg Gly Pro Arg Glu  Phe Cys Val Lys Val  Leu Cys Pro 
    2705                 2710                 2715             


Tyr Met  Pro Lys Val Ile Glu  Lys Met Glu Leu Leu  Gln Arg Arg 
    2720                 2725                 2730             


Tyr Gly  Gly Gly Leu Val Arg  Asn Pro Leu Ser Arg  Asn Ser Thr 
    2735                 2740                 2745             


His Glu  Met Tyr Trp Val Ser  Arg Ala Ser Gly Asn  Val Val His 
    2750                 2755                 2760             


Ser Val  Asn Met Thr Ser Gln  Val Leu Leu Gly Arg  Met Glu Lys 
    2765                 2770                 2775             


Arg Thr  Trp Lys Gly Pro Gln  Tyr Glu Glu Asp Val  Asn Leu Gly 
    2780                 2785                 2790             


Ser Gly  Thr Arg Ala Val Gly  Lys Pro Leu Leu Asn  Ser Asp Thr 
    2795                 2800                 2805             


Ser Lys  Ile Lys Asn Arg Ile  Glu Arg Leu Arg Arg  Glu Tyr Ser 
    2810                 2815                 2820             


Ser Thr  Trp His His Asp Glu  Asn His Pro Tyr Arg  Thr Trp Asn 
    2825                 2830                 2835             


Tyr His  Gly Ser Tyr Asp Val  Lys Pro Thr Gly Ser  Ala Ser Ser 
    2840                 2845                 2850             


Leu Val  Asn Gly Val Val Arg  Leu Leu Ser Lys Pro  Trp Asp Thr 
    2855                 2860                 2865             


Ile Thr  Asn Val Thr Thr Met  Ala Met Thr Asp Thr  Thr Pro Phe 
    2870                 2875                 2880             


Gly Gln  Gln Arg Val Phe Lys  Glu Lys Val Asp Thr  Lys Ala Pro 
    2885                 2890                 2895             


Glu Pro  Pro Glu Gly Val Lys  Tyr Val Leu Asn Glu  Thr Thr Asn 
    2900                 2905                 2910             


Trp Leu  Trp Ala Phe Leu Ala  Arg Glu Lys Arg Pro  Arg Met Cys 
    2915                 2920                 2925             


Ser Arg  Glu Glu Phe Ile Arg  Lys Val Asn Ser Asn  Ala Ala Leu 
    2930                 2935                 2940             


Gly Ala  Met Phe Glu Glu Gln  Asn Gln Trp Arg Ser  Ala Arg Glu 
    2945                 2950                 2955             


Ala Val  Glu Asp Pro Lys Phe  Trp Glu Met Val Asp  Glu Glu Arg 
    2960                 2965                 2970             


Glu Ala  His Leu Arg Gly Glu  Cys His Thr Cys Ile  Tyr Asn Met 
    2975                 2980                 2985             


Met Gly  Lys Arg Glu Lys Lys  Pro Gly Glu Phe Gly  Lys Ala Lys 
    2990                 2995                 3000             


Gly Ser  Arg Ala Ile Trp Phe  Met Trp Leu Gly Ala  Arg Phe Leu 
    3005                 3010                 3015             


Glu Phe  Glu Ala Leu Gly Phe  Leu Asn Glu Asp His  Trp Leu Gly 
    3020                 3025                 3030             


Arg Lys  Asn Ser Gly Gly Gly  Val Glu Gly Leu Gly  Leu Gln Lys 
    3035                 3040                 3045             


Leu Gly  Tyr Ile Leu Arg Glu  Val Gly Thr Arg Pro  Gly Gly Lys 
    3050                 3055                 3060             


Ile Tyr  Ala Asp Asp Thr Ala  Gly Trp Asp Thr Arg  Ile Thr Arg 
    3065                 3070                 3075             


Ala Asp  Leu Glu Asn Glu Ala  Lys Val Leu Glu Leu  Leu Asp Gly 
    3080                 3085                 3090             


Glu His  Arg Arg Leu Ala Arg  Ala Ile Ile Glu Leu  Thr Tyr Arg 
    3095                 3100                 3105             


His Lys  Val Val Lys Val Met  Arg Pro Ala Ala Asp  Gly Arg Thr 
    3110                 3115                 3120             


Val Met  Asp Val Ile Ser Arg  Glu Asp Gln Arg Gly  Ser Gly Gln 
    3125                 3130                 3135             


Val Val  Thr Tyr Ala Leu Asn  Thr Phe Thr Asn Leu  Ala Val Gln 
    3140                 3145                 3150             


Leu Val  Arg Met Met Glu Gly  Glu Gly Val Ile Gly  Pro Asp Asp 
    3155                 3160                 3165             


Val Glu  Lys Leu Thr Lys Gly  Lys Gly Pro Lys Val  Arg Thr Trp 
    3170                 3175                 3180             


Leu Phe  Glu Asn Gly Glu Glu  Arg Leu Ser Arg Met  Ala Val Ser 
    3185                 3190                 3195             


Gly Asp  Asp Cys Val Val Lys  Pro Leu Asp Asp Arg  Phe Ala Thr 
    3200                 3205                 3210             


Ser Leu  His Phe Leu Asn Ala  Met Ser Lys Val Arg  Lys Asp Ile 
    3215                 3220                 3225             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Tyr Asp Trp  Gln Gln Val 
    3230                 3235                 3240             


Pro Phe  Cys Ser Asn His Phe  Thr Glu Leu Ile Met  Lys Asp Gly 
    3245                 3250                 3255             


Arg Thr  Leu Val Val Pro Cys  Arg Gly Gln Asp Glu  Leu Val Gly 
    3260                 3265                 3270             


Arg Ala  Arg Ile Ser Pro Gly  Ala Gly Trp Asn Val  Arg Asp Thr 
    3275                 3280                 3285             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Leu  Leu Leu Tyr 
    3290                 3295                 3300             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3305                 3310                 3315             


Ala Val  Pro Val Asn Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3320                 3325                 3330             


Ile His  Ala Gly Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Glu 
    3335                 3340                 3345             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Glu Trp  Met Glu Asp 
    3350                 3355                 3360             


Lys Thr  Pro Val Glu Lys Trp  Ser Asp Val Pro Tyr  Ser Gly Lys 
    3365                 3370                 3375             


Arg Glu  Asp Ile Trp Cys Gly  Ser Leu Ile Gly Thr  Arg Ala Arg 
    3380                 3385                 3390             


Ala Thr  Trp Ala Glu Asn Ile  Gln Val Ala Ile Asn  Gln Val Arg 
    3395                 3400                 3405             


Ala Ile  Ile Gly Asp Glu Lys  Tyr Val Asp Tyr Met  Ser Ser Leu 
    3410                 3415                 3420             


Lys Arg  Tyr Glu Asp Thr Thr  Leu Val Glu Asp Thr  Val Leu 
    3425                 3430                 3435         


<210>  9
<211>  11905
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc      120

ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt      180

ggactgaaga gggctatgtt gatggctcag tcaaagcacg gtctaacaaa agaaatgaca      240

atgaaatacc gtatggaagg gtgcgtcgat ggacataaat ttgtgatcac gggagagggc      300

attggatatc cgttcaaagg gaaacaggct attaatctgt gtgtggtcga aggtggacca      360

ttgccatttg ccgaagacat attgtcagct gcctttatgt acggaaacag ggttttcact      420

gaatatcctc aagacatagc tgactatttc aagaactcgt gtcctgctgg ttatacatgg      480

gacaggtctt ttctctttga ggatggagca gtttgcatat gtaatgcaga tataacagtg      540

agtgttgaag aaaactgcat gtatcatgag tccaaatttt atggagtgaa ttttcctgct      600

gatggacctg tgatgaaaaa gatgacagat aactgggagc catcctgcga gaagatcata      660

ccagtaccta agcaggggat attgaaaggg gatgtctcca tgtacctcct tctgaaggat      720

ggtgggcgtt tacggtgcca attcgacaca gtttacaaag caaagtctgt gccaagaaag      780

atgccggact ggcacttcat ccagcataag ctcacccgtg aagaccgcag cgatgctaag      840

aatcagaaat ggcatctgac agaacatgct attgcatccg gatctgcatt gcccggaagc      900

ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct      960

atgtccaaaa agcccggcgg tcctgggaaa tccagagccg tgaacatgtt gaaaaggggg     1020

atgccacggg tactgagtct gatcggcctc aaaagagcca tgttgagcct gatcgacggc     1080

aaggggccaa tacgatttgt gttggctctc ttggcgttct tcaggttcac agcaattgct     1140

ccgacccgag cagtgctgga tcgatggaga ggtgtgaaca aacaaacagc gatgaaacac     1200

cttctgagtt ttaagaagga actagggacc ttgaccagtg ctatcaatcg gcggagttcg     1260

aaacaaaaga aaagaggagg aaagaccgga attgcagtca tgattggcct gatcgccagc     1320

gctatggcag cggaggtcac tagacgtggg agtgcatact atatgtactt ggacagaaac     1380

gatgctgggg aggccatatc ttttccaacc acattgggga tgaataagtg ttatatacag     1440

atcatggatc ttggacacat gtgtgatgcc accatgagct atgaatgccc tatgctggat     1500

gagggggtgg aaccagatga cgtcgattgt tggtgcaaca cgacgtcaac ttgggttgtg     1560

tacggaacct gccatcacaa aaaaggtgaa gcacggagaa gtagaagagc tgtgacgctc     1620

ccctcccatt ccactaggaa gctgcaaacg cggtcgcaaa cctggttgga atcaagagaa     1680

tacacaaagc acttgattag agtcgaaaat tggatattca ggaaccctgg cttcgcgtta     1740

gcagcagctg ccatcgcttg gcttttggga agctcaacga gccaaaaagt catatacttg     1800

gtcatgatac tgctgattgc cccggcatac agcatcaggt gcataggagt cagcaatagg     1860

gactttgtgg aaggtatgtc aggtgggact tgggttgata ttgtcttgga acatggaggt     1920

tgtgtcaccg taatggcaca ggacaaaccg actgtcgaca tagagctggt tacaacaaca     1980

gtcagcaaca tggcggaggt aagatcctac tgctatgagg catcaatatc agacatggct     2040

tcggacagcc gctgcccaac acaaggtgaa gcctaccttg acaagcaatc agacactcaa     2100

tatgtctgca aaagaacgtt agtggacaga ggctggggaa atggatgtgg actttttggc     2160

aaagggagtc tggtgacatg cgctaagttt gcatgctcca agaaaatgac cgggaagagc     2220

atccagccag agaatctgga gtaccggata atgctgtcag ttcatggctc ccagcacagt     2280

gggatgatcg ttaatgacac aggacatgaa actgatgaga atagagcgaa ggttgagata     2340

acgcccaatt caccaagagc cgaagccacc ctggggggtt ttggaagcct aggacttgat     2400

tgtgaaccga ggacaggcct tgacttttca gatttgtatt acttgactat gaataacaag     2460

cactggttgg ttcacaagga gtggttccac gacattccat taccttggca cgctggggca     2520

gacaccggaa ctccacactg gaacaacaaa gaagcactgg tagagttcaa ggacgcacat     2580

gccaaaaggc aaactgtcgt ggttctaggg agtcaagaag gagcagttca cacggccctt     2640

gctggagctc tggaggctga gatggatggt gcaaagggaa ggctgtcctc tggccacttg     2700

aaatgtcgcc tgaaaatgga taaacttaga ttgaagggcg tgtcatactc cttgtgtacc     2760

gcagcgttca cattcaccaa gatcccggct gaaacactgc acgggacagt cacagtggag     2820

gtacagtacg cagggacaga tggaccttgc aaggttccag ctcagatggc ggtggacatg     2880

caaactctga ccccagttgg gaggttgata accgctaacc ccgtaatcac tgaaagcact     2940

gagaactcta agatgatgct ggaacttgat ccaccatttg gggactctta cattgtcata     3000

ggagtcgggg agaagaagat cacccaccac tggcacagga gtggcagcac cattggaaaa     3060

gcatttgaag ccactgtgag aggtgccaag agaatggcag tcttgggaga cacagcctgg     3120

gactttggat cagttggagg cgctctcaac tcattgggca agggcatcca tcaaattttt     3180

ggagcagctt tcaaatcatt gtttggagga atgtcctggt tctcacaaat tctcattgga     3240

acgttgctga tgtggttggg tctgaacaca aagaatggat ctatttccct tatgtgcttg     3300

gccttagggg gagtgttgat cttcttatcc acagccgtct ctgctgattc cggatgtgcc     3360

atagacatca gccggcaaga gctgagatgt ggaagtggag tgttcataca caatgatgtg     3420

gaggcttgga tggaccggta caagtattac cctgaaacgc cacaaggcct agccaagatc     3480

attcagaaag ctcataagga aggagtgtgc ggtctacgat cagtttccag actggagcat     3540

caaatgtggg aagcagtgaa ggacgagctg aacactcttt tgaaggagaa tggtgtggac     3600

cttagtgtcg tggttgagaa acaggaggga atgtacaagt cagcacctaa acgcctcacc     3660

gccaccacgg aaaaattgga aattggctgg aaggcctggg gaaagagtat tttatttgca     3720

ccagaactcg ccaacaacac ctttgtggtt gatggtccgg agaccaagga atgtccgact     3780

cagaatcgcg cttggaatag cttagaagtg gaggattttg gatttggtct caccagcact     3840

cggatgttcc tgaaggtcag agagagcaac acaactgaat gtgactcgaa gatcattgga     3900

acggctgtca agaacaactt ggcgatccac agtgacctgt cctattggat tgaaagcagg     3960

ctcaatgata cgtggaagct tgaaagggca gttctgggtg aagtcaaatc atgtacgtgg     4020

cctgagacgc ataccttgtg gggcgatgga atccttgaga gtgacttgat aataccagtc     4080

acactggcgg gaccacgaag caatcacaat cggagacctg ggtacaagac acaaaaccag     4140

ggcccatggg acgaaggccg ggtagagatt gacttcgatt actgcccagg aactacggtc     4200

accctgagtg agagctgcgg acaccgtgga cctgccactc gcaccaccac agagagcgga     4260

aagttgataa cagattggtg ctgcaggagc tgcaccttac caccactgcg ctaccaaact     4320

gacagcggct gttggtatgg tatggagatc agaccacaga gacatgatga aaagaccctc     4380

gtgcagtcac aagtgaatgc ttataatgct gatatgattg acccttttca gttgggcctt     4440

ctggtcgtgt tcttggccac ccaggaggtc cttcgcaaga ggtggacagc caagatcagc     4500

atgccagcta tactgattgc tctgctagtc ctggtgtttg ggggcattac ttacactgat     4560

gtgttacgct atgtcatctt ggtgggggca gctttcgcag aatctaattc gggaggagac     4620

gtggtacact tggcgctcat ggcgaccttc aagatacaac cagtgtttat ggtggcatcg     4680

tttctcaaag cgagatggac caaccaggag aacattttgt tgatgttggc ggctgttttc     4740

tttcaaatgg cttattacga tgcccgccaa attctgctct gggagatccc tgatgtgttg     4800

aattcactgg cggtagcttg gatgatactg agagccataa cattcacaac gacatcaaac     4860

gtggttgttc cgctgctagc cctgctaaca cccgggctga gatgcttgaa tctggatgtg     4920

tacaggatac tgctgttgat ggtcggaata ggcagcttga tcagggagaa gaggagtgca     4980

gctgcaaaaa agaaaggagc aagtctgcta tgcttggctc tagcctcaac aggacttttc     5040

aaccccatga tccttgctgc tggactgatt gcatgtgatc ccaaccgtaa acgcggatgg     5100

cccgcaactg aagtgatgac agctgtcggc ctaatgtttg ccatcgtcgg agggctggca     5160

gagcttgaca ttgactccat ggccattcca atgactatcg cggggctcat gtttgctgct     5220

ttcgtgattt ctgggaaatc aacagatatg tggattgaga gaacggcgga catttcctgg     5280

gaaagtgatg cagaaattac aggctcgagc gaaagagttg atgtgcggct tgatgatgat     5340

ggaaacttcc agctcatgaa tgatccagga gcaccttgga agatatggat gctcagaatg     5400

gtctgtctcg cgattagtgc gtacaccccc tgggcaatct tgccctcagt agttggattt     5460

tggataactc tccaatacac aaagagagga ggcgtgttgt gggacactcc ctcaccaaag     5520

gagtacaaaa agggggacac gaccaccggc gtctacagga tcatgactcg tgggctgctc     5580

ggcagttatc aagcaggagc gggcgtgatg gttgaaggtg ttttccacac cctttggcat     5640

acaacaaaag gagccgcttt gatgagcgga gagggccgcc tggacccata ctggggcagt     5700

gtcaaggagg atcgactttg ttacggagga ccctggaaat tgcagcacaa gtggaacggg     5760

caggatgagg tgcagatgat tgtggtggaa cctggcagga acgttaagaa cgtccagacg     5820

aaaccagggg tgttcaaaac acctgaagga gaaatcgggg ccgtgacttt ggacttcccc     5880

actggaacat caggctcacc aatagtggac aaaaacggtg atgtgattgg gctttatggc     5940

aatggagtca taatgcccaa cggctcatac ataagcgcga tagtgcaggg tgaaaggatg     6000

gatgagccaa tcccagccgg attcgaacct gagatgctga ggaaaaaaca gatcactgta     6060

ctggatctcc atcccggcgc cggtaaaaca aggaggattc tgccacagat catcaaagag     6120

gccataaaca gaagactgag aacagccgtg ctagcaccaa ccagggttgt ggctgctgag     6180

atggctgaag cactgagagg actgcccatc cggtaccaga catccgcagt gcccagagaa     6240

cataatggaa atgagattgt tgatgtcatg tgtcatgcta ccctcaccca caggctgatg     6300

tctcctcaca gggtgccgaa ctacaacctg ttcgtgatgg atgaggctca tttcaccgac     6360

ccagctagca ttgcagcaag aggttacatt tccacaaagg tcgagctagg ggaggcggcg     6420

gcaatattca tgacagccac cccaccaggc acttcagatc cattcccaga gtccaattca     6480

ccaatttccg acttacagac tgagatcccg gatcgagctt ggaactctgg atacgaatgg     6540

atcacagaat acaccgggaa gacggtttgg tttgtgccta gtgtcaagat ggggaatgag     6600

attgcccttt gcctacaacg tgctggaaag aaagtagtcc aattgaacag aaagtcgtac     6660

gagacggagt acccaaaatg taagaacgat gattgggact ttgttatcac aacagacata     6720

tctgaaatgg gggctaactt caaggcgagc agggtgattg acagccggaa gagtgtgaaa     6780

ccaaccatca taacagaagg agaagggaga gtgatcctgg gagaaccatc tgcagtgaca     6840

gcagctagtg ccgcccagag acgtggacgt atcggtagaa atccgtcgca agttggtgat     6900

gagtactgtt atggggggca cacgaatgaa gacgactcga acttcgccca ttggactgag     6960

gcacgaatca tgctggacaa catcaacatg ccaaacggac tgatcgctca attctaccaa     7020

ccagagcgtg agaaggtata taccatggat ggggaatacc ggctcagagg agaagagaga     7080

aaaaactttc tggaactgtt gaggactgca gatctgccag tttggctggc ttacaaggtt     7140

gcagcggctg gagtgtcata ccacgaccgg aggtggtgct ttgatggtcc taggacaaac     7200

acaattttag aagacaacaa cgaagtggaa gtcatcacga agcttggtga aaggaagatt     7260

ctgaggccgc gctggattga cgccagggtg tactcggatc accaggcact aaaggcgttc     7320

aaggacttcg cctcgggaaa acgttctcag atagggctca ttgaggttct gggaaagatg     7380

cctgagcact tcatggggaa gacatgggaa gcacttgaca ccatgtacgt tgtggccact     7440

gcagagaaag gaggaagagc tcacagaatg gccctggagg aactgccaga tgctcttcag     7500

acaattgcct tgattgcctt attgagtgtg atgaccatgg gagtattctt cctcctcatg     7560

cagcggaagg gcattggaaa gataggtttg ggaggcgctg tcttgggagt cgcgaccttt     7620

ttctgttgga tggctgaagt tccaggaacg aagatcgccg gaatgttgct gctctccctt     7680

ctcttgatga ttgtgctaat tcctgagcca gagaagcaac gttcgcagac agacaaccag     7740

ctagccgtgt tcctgatttg tgtcatgacc cttgtgagcg cagtggcagc caacgagatg     7800

ggttggctag ataagaccaa gagtgacata agcagtttgt ttgggcaaag aattgaggtc     7860

aaggagaatt tcagcatggg agagtttctt ttggacttga ggcctgcaac agcctggtca     7920

ctgtacgctg tgacaacagc ggtcctcact ccactgctaa agcatttgat cacgtcagat     7980

tacatcaaca cctcattgac ctcaataaac gttcaggcaa gtgcactatt cacactcgcg     8040

cgaggcttcc ccttcgtcga tgttggagtg tcggctctcc tgctagcagc cggatgctgg     8100

ggacaagtca ccctcaccgt tacggtaaca gcggcaacac tccttttttg ccactatgcc     8160

tacatggttc ccggttggca agctgaggca atgcgctcag cccagcggcg gacagcggcc     8220

ggaatcatga agaacgctgt agtggatggc atcgtggcca cggacgtccc agaattagag     8280

cgcaccacac ccatcatgca gaagaaagtt ggacagatca tgctgatctt ggtgtctcta     8340

gctgcagtag tagtgaaccc gtctgtgaag acagtacgag aagccggaat tttgatcacg     8400

gccgcagcgg tgacgctttg ggagaatgga gcaagctctg tttggaacgc aacaactgcc     8460

atcggactct gccacatcat gcgtgggggt tggttgtcat gtctatccat aacatggaca     8520

ctcataaaga acatggaaaa accaggacta aaaagaggtg gggcaaaagg acgcaccttg     8580

ggagaggttt ggaaagaaag actcaaccag atgacaaaag aagagttcac taggtaccgc     8640

aaagaggcca tcatcgaagt cgatcgctca gcggcaaaac acgccaggaa agaaggcaat     8700

gtcactggag ggcatccagt ctctaggggc acagcaaaac tgagatggct ggtcgaacgg     8760

aggtttctcg aaccggtcgg aaaagtgatt gaccttggat gtggaagagg cggttggtgt     8820

tactatatgg caacccaaaa aagagtccaa gaagtcagag ggtacacaaa gggcggtccc     8880

ggacatgaag agccccaact agtgcaaagt tatggatgga acattgtcac catgaagagt     8940

ggagtggatg tgttctacag accttctgag tgttgtgaca ccctcctttg tgacatcgga     9000

gagtcctcgt caagtgctga ggttgaagag cataggacga ttcgggtcct tgaaatggtt     9060

gaggactggc tgcaccgagg gccaagggaa ttttgcgtga aggtgctctg cccctacatg     9120

ccgaaagtca tagagaagat ggagctgctc caacgccggt atgggggggg actggtcaga     9180

aacccactct cacggaattc cacgcacgag atgtattggg tgagtcgagc ttcaggcaat     9240

gtggtacatt cagtgaatat gaccagccag gtgctcctag gaagaatgga aaaaaggacc     9300

tggaagggac cccaatacga ggaagatgta aacttgggaa gtggaaccag ggcggtggga     9360

aaacccctgc tcaactcaga caccagtaaa atcaagaaca ggattgaacg actcaggcgt     9420

gagtacagtt cgacgtggca ccacgatgag aaccacccat atagaacctg gaactatcac     9480

ggcagttatg atgtgaagcc cacaggctcc gccagttcgc tggtcaatgg agtggtcagg     9540

ctcctctcaa aaccatggga caccatcacg aatgttacca ccatggccat gactgacact     9600

actcccttcg ggcagcagcg agtgttcaaa gagaaggtgg acacgaaagc tcctgaaccg     9660

ccagaaggag tgaagtacgt gctcaacgag accaccaact ggttgtgggc gtttttggcc     9720

agagaaaaac gtcccagaat gtgctctcga gaggaattca taagaaaggt caacagcaat     9780

gcagctttgg gtgccatgtt tgaagagcag aatcaatgga ggagcgccag agaagcagtt     9840

gaagatccaa aattttggga gatggtggat gaggagcgcg aggcacatct gcggggggaa     9900

tgtcacactt gcatttacaa catgatggga aagagagaga aaaaacccgg agagttcgga     9960

aaggccaagg gaagcagagc catttggttc atgtggctcg gagctcgctt tctggagttc    10020

gaggctctgg gttttctcaa tgaagaccac tggcttggaa gaaagaactc aggaggaggt    10080

gtcgagggct tgggcctcca aaaactgggt tacatcctgc gtgaagttgg cacccggcct    10140

gggggcaaga tctatgctga tgacacagct ggctgggaca cccgcatcac gagagctgac    10200

ttggaaaatg aagctaaggt gcttgagctg cttgatgggg aacatcggcg tcttgccagg    10260

gccatcattg agctcaccta tcgtcacaaa gttgtgaaag tgatgcgccc ggctgctgat    10320

ggaagaaccg tcatggatgt tatctccaga gaagatcaga gggggagtgg acaagttgtc    10380

acctacgccc taaacacttt caccaacctg gccgtccagc tggtgaggat gatggaaggg    10440

gaaggagtga ttggcccaga tgatgtggag aaactcacaa aagggaaagg acccaaagtc    10500

aggacctggc tgtttgagaa tggggaagaa agactcagcc gcatggctgt cagtggagat    10560

gactgtgtgg taaagcccct ggacgatcgc tttgccacct cgctccactt cctcaatgct    10620

atgtcaaagg ttcgcaaaga catccaagag tggaaaccgt caactggatg gtatgattgg    10680

cagcaggttc cattttgctc aaaccatttc actgaattga tcatgaaaga tggaagaaca    10740

ctggtggttc catgccgagg acaggatgaa ttggtaggca gagctcgcat atctccaggg    10800

gccggatgga acgtccgcga cactgcttgt ctggctaagt cttatgccca gatgtggctg    10860

cttctgtact tccacagaag agacctgcgg ctcatggcca acgccatttg ctccgctgtc    10920

cctgtgaatt gggtccctac cggaagaacc acgtggtcca tccatgcagg aggagagtgg    10980

atgacaacag aggacatgtt ggaggtctgg aaccgtgttt ggatagagga gaatgaatgg    11040

atggaagaca aaaccccagt ggagaaatgg agtgacgtcc catattcagg aaaacgagag    11100

gacatctggt gtggcagcct gattggcaca agagcccgag ccacgtgggc agaaaacatc    11160

caggtggcta tcaaccaagt cagagcaatc atcggagatg agaagtatgt ggattacatg    11220

agttcactaa agagatatga agacacaact ttggttgagg acacagtact gtagatattt    11280

aatcaattgt aaatagacaa tataagtatg cataaaagtg tagttttata gtagtattta    11340

gtggtgttag tgtaaatagt taagaaaatt ttgaggagaa agtcaggccg ggaagttccc    11400

gccaccggaa gttgagtaga cggtgctgcc tgcgactcaa ccccaggagg actgggtgaa    11460

caaagccgcg aagtgatcca tgtaagccct cagaaccgtc tcggaaggag gaccccacat    11520

gttgtaactt caaagcccaa tgtcagacca cgctacggcg tgctactctg cggagagtgc    11580

agtctgcgat agtgccccag gaggactggg ttaacaaagg caaaccaacg ccccacgcgg    11640

ccctagcccc ggtaatggtg ttaaccaggg cgaaaggact agaggttaga ggagaccccg    11700

cggtttaaag tgcacggccc agcctggctg aagctgtagg tcaggggaag gactagaggt    11760

tagtggagac cccgtgccac aaaacaccac aacaaaacag catattgaca cctgggatag    11820

actaggagat cttctgctct gcacaaccag ccacacggca cagtgcgccg acaatggtgg    11880

ctggtggtgc gagaacacag gatct                                          11905


<210>  10
<211>  3725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Met Ala Gln Ser Lys His Gly Leu Thr Lys Glu Met Thr 
        35                  40                  45              


Met Lys Tyr Arg Met Glu Gly Cys Val Asp Gly His Lys Phe Val Ile 
    50                  55                  60                  


Thr Gly Glu Gly Ile Gly Tyr Pro Phe Lys Gly Lys Gln Ala Ile Asn 
65                  70                  75                  80  


Leu Cys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Glu Asp Ile Leu 
                85                  90                  95      


Ser Ala Ala Phe Met Tyr Gly Asn Arg Val Phe Thr Glu Tyr Pro Gln 
            100                 105                 110         


Asp Ile Ala Asp Tyr Phe Lys Asn Ser Cys Pro Ala Gly Tyr Thr Trp 
        115                 120                 125             


Asp Arg Ser Phe Leu Phe Glu Asp Gly Ala Val Cys Ile Cys Asn Ala 
    130                 135                 140                 


Asp Ile Thr Val Ser Val Glu Glu Asn Cys Met Tyr His Glu Ser Lys 
145                 150                 155                 160 


Phe Tyr Gly Val Asn Phe Pro Ala Asp Gly Pro Val Met Lys Lys Met 
                165                 170                 175     


Thr Asp Asn Trp Glu Pro Ser Cys Glu Lys Ile Ile Pro Val Pro Lys 
            180                 185                 190         


Gln Gly Ile Leu Lys Gly Asp Val Ser Met Tyr Leu Leu Leu Lys Asp 
        195                 200                 205             


Gly Gly Arg Leu Arg Cys Gln Phe Asp Thr Val Tyr Lys Ala Lys Ser 
    210                 215                 220                 


Val Pro Arg Lys Met Pro Asp Trp His Phe Ile Gln His Lys Leu Thr 
225                 230                 235                 240 


Arg Glu Asp Arg Ser Asp Ala Lys Asn Gln Lys Trp His Leu Thr Glu 
                245                 250                 255     


His Ala Ile Ala Ser Gly Ser Ala Leu Pro Gly Ser Gly Ala Thr Asn 
            260                 265                 270         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        275                 280                 285             


Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
    290                 295                 300                 


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
305                 310                 315                 320 


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
                325                 330                 335     


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
            340                 345                 350         


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
        355                 360                 365             


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
    370                 375                 380                 


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala 
385                 390                 395                 400 


Val Met Ile Gly Leu Ile Ala Ser Ala Met Ala Ala Glu Val Thr Arg 
                405                 410                 415     


Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu 
            420                 425                 430         


Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln 
        435                 440                 445             


Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys 
    450                 455                 460                 


Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys 
465                 470                 475                 480 


Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys 
                485                 490                 495     


Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser 
            500                 505                 510         


Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu 
        515                 520                 525             


Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro 
    530                 535                 540                 


Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser 
545                 550                 555                 560 


Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro 
                565                 570                 575     


Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu 
            580                 585                 590         


Gly Met Ser Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly 
        595                 600                 605             


Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu 
    610                 615                 620                 


Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr 
625                 630                 635                 640 


Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln 
                645                 650                 655     


Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys 
            660                 665                 670         


Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly 
        675                 680                 685             


Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met 
    690                 695                 700                 


Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu 
705                 710                 715                 720 


Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly 
                725                 730                 735     


His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser 
            740                 745                 750         


Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp 
        755                 760                 765             


Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr 
    770                 775                 780                 


Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile 
785                 790                 795                 800 


Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn 
                805                 810                 815     


Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln 
            820                 825                 830         


Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu 
        835                 840                 845             


Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser 
    850                 855                 860                 


Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys 
865                 870                 875                 880 


Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile 
                885                 890                 895     


Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala 
            900                 905                 910         


Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met 
        915                 920                 925             


Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile 
    930                 935                 940                 


Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro 
945                 950                 955                 960 


Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr 
                965                 970                 975     


His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala 
            980                 985                 990         


Thr Val Arg Gly Ala Lys Arg Met  Ala Val Leu Gly Asp  Thr Ala Trp 
        995                 1000                 1005             


Asp Phe  Gly Ser Val Gly Gly  Ala Leu Asn Ser Leu  Gly Lys Gly 
    1010                 1015                 1020             


Ile His  Gln Ile Phe Gly Ala  Ala Phe Lys Ser Leu  Phe Gly Gly 
    1025                 1030                 1035             


Met Ser  Trp Phe Ser Gln Ile  Leu Ile Gly Thr Leu  Leu Met Trp 
    1040                 1045                 1050             


Leu Gly  Leu Asn Thr Lys Asn  Gly Ser Ile Ser Leu  Met Cys Leu 
    1055                 1060                 1065             


Ala Leu  Gly Gly Val Leu Ile  Phe Leu Ser Thr Ala  Val Ser Ala 
    1070                 1075                 1080             


Asp Ser  Gly Cys Ala Ile Asp  Ile Ser Arg Gln Glu  Leu Arg Cys 
    1085                 1090                 1095             


Gly Ser  Gly Val Phe Ile His  Asn Asp Val Glu Ala  Trp Met Asp 
    1100                 1105                 1110             


Arg Tyr  Lys Tyr Tyr Pro Glu  Thr Pro Gln Gly Leu  Ala Lys Ile 
    1115                 1120                 1125             


Ile Gln  Lys Ala His Lys Glu  Gly Val Cys Gly Leu  Arg Ser Val 
    1130                 1135                 1140             


Ser Arg  Leu Glu His Gln Met  Trp Glu Ala Val Lys  Asp Glu Leu 
    1145                 1150                 1155             


Asn Thr  Leu Leu Lys Glu Asn  Gly Val Asp Leu Ser  Val Val Val 
    1160                 1165                 1170             


Glu Lys  Gln Glu Gly Met Tyr  Lys Ser Ala Pro Lys  Arg Leu Thr 
    1175                 1180                 1185             


Ala Thr  Thr Glu Lys Leu Glu  Ile Gly Trp Lys Ala  Trp Gly Lys 
    1190                 1195                 1200             


Ser Ile  Leu Phe Ala Pro Glu  Leu Ala Asn Asn Thr  Phe Val Val 
    1205                 1210                 1215             


Asp Gly  Pro Glu Thr Lys Glu  Cys Pro Thr Gln Asn  Arg Ala Trp 
    1220                 1225                 1230             


Asn Ser  Leu Glu Val Glu Asp  Phe Gly Phe Gly Leu  Thr Ser Thr 
    1235                 1240                 1245             


Arg Met  Phe Leu Lys Val Arg  Glu Ser Asn Thr Thr  Glu Cys Asp 
    1250                 1255                 1260             


Ser Lys  Ile Ile Gly Thr Ala  Val Lys Asn Asn Leu  Ala Ile His 
    1265                 1270                 1275             


Ser Asp  Leu Ser Tyr Trp Ile  Glu Ser Arg Leu Asn  Asp Thr Trp 
    1280                 1285                 1290             


Lys Leu  Glu Arg Ala Val Leu  Gly Glu Val Lys Ser  Cys Thr Trp 
    1295                 1300                 1305             


Pro Glu  Thr His Thr Leu Trp  Gly Asp Gly Ile Leu  Glu Ser Asp 
    1310                 1315                 1320             


Leu Ile  Ile Pro Val Thr Leu  Ala Gly Pro Arg Ser  Asn His Asn 
    1325                 1330                 1335             


Arg Arg  Pro Gly Tyr Lys Thr  Gln Asn Gln Gly Pro  Trp Asp Glu 
    1340                 1345                 1350             


Gly Arg  Val Glu Ile Asp Phe  Asp Tyr Cys Pro Gly  Thr Thr Val 
    1355                 1360                 1365             


Thr Leu  Ser Glu Ser Cys Gly  His Arg Gly Pro Ala  Thr Arg Thr 
    1370                 1375                 1380             


Thr Thr  Glu Ser Gly Lys Leu  Ile Thr Asp Trp Cys  Cys Arg Ser 
    1385                 1390                 1395             


Cys Thr  Leu Pro Pro Leu Arg  Tyr Gln Thr Asp Ser  Gly Cys Trp 
    1400                 1405                 1410             


Tyr Gly  Met Glu Ile Arg Pro  Gln Arg His Asp Glu  Lys Thr Leu 
    1415                 1420                 1425             


Val Gln  Ser Gln Val Asn Ala  Tyr Asn Ala Asp Met  Ile Asp Pro 
    1430                 1435                 1440             


Phe Gln  Leu Gly Leu Leu Val  Val Phe Leu Ala Thr  Gln Glu Val 
    1445                 1450                 1455             


Leu Arg  Lys Arg Trp Thr Ala  Lys Ile Ser Met Pro  Ala Ile Leu 
    1460                 1465                 1470             


Ile Ala  Leu Leu Val Leu Val  Phe Gly Gly Ile Thr  Tyr Thr Asp 
    1475                 1480                 1485             


Val Leu  Arg Tyr Val Ile Leu  Val Gly Ala Ala Phe  Ala Glu Ser 
    1490                 1495                 1500             


Asn Ser  Gly Gly Asp Val Val  His Leu Ala Leu Met  Ala Thr Phe 
    1505                 1510                 1515             


Lys Ile  Gln Pro Val Phe Met  Val Ala Ser Phe Leu  Lys Ala Arg 
    1520                 1525                 1530             


Trp Thr  Asn Gln Glu Asn Ile  Leu Leu Met Leu Ala  Ala Val Phe 
    1535                 1540                 1545             


Phe Gln  Met Ala Tyr Tyr Asp  Ala Arg Gln Ile Leu  Leu Trp Glu 
    1550                 1555                 1560             


Ile Pro  Asp Val Leu Asn Ser  Leu Ala Val Ala Trp  Met Ile Leu 
    1565                 1570                 1575             


Arg Ala  Ile Thr Phe Thr Thr  Thr Ser Asn Val Val  Val Pro Leu 
    1580                 1585                 1590             


Leu Ala  Leu Leu Thr Pro Gly  Leu Arg Cys Leu Asn  Leu Asp Val 
    1595                 1600                 1605             


Tyr Arg  Ile Leu Leu Leu Met  Val Gly Ile Gly Ser  Leu Ile Arg 
    1610                 1615                 1620             


Glu Lys  Arg Ser Ala Ala Ala  Lys Lys Lys Gly Ala  Ser Leu Leu 
    1625                 1630                 1635             


Cys Leu  Ala Leu Ala Ser Thr  Gly Leu Phe Asn Pro  Met Ile Leu 
    1640                 1645                 1650             


Ala Ala  Gly Leu Ile Ala Cys  Asp Pro Asn Arg Lys  Arg Gly Trp 
    1655                 1660                 1665             


Pro Ala  Thr Glu Val Met Thr  Ala Val Gly Leu Met  Phe Ala Ile 
    1670                 1675                 1680             


Val Gly  Gly Leu Ala Glu Leu  Asp Ile Asp Ser Met  Ala Ile Pro 
    1685                 1690                 1695             


Met Thr  Ile Ala Gly Leu Met  Phe Ala Ala Phe Val  Ile Ser Gly 
    1700                 1705                 1710             


Lys Ser  Thr Asp Met Trp Ile  Glu Arg Thr Ala Asp  Ile Ser Trp 
    1715                 1720                 1725             


Glu Ser  Asp Ala Glu Ile Thr  Gly Ser Ser Glu Arg  Val Asp Val 
    1730                 1735                 1740             


Arg Leu  Asp Asp Asp Gly Asn  Phe Gln Leu Met Asn  Asp Pro Gly 
    1745                 1750                 1755             


Ala Pro  Trp Lys Ile Trp Met  Leu Arg Met Val Cys  Leu Ala Ile 
    1760                 1765                 1770             


Ser Ala  Tyr Thr Pro Trp Ala  Ile Leu Pro Ser Val  Val Gly Phe 
    1775                 1780                 1785             


Trp Ile  Thr Leu Gln Tyr Thr  Lys Arg Gly Gly Val  Leu Trp Asp 
    1790                 1795                 1800             


Thr Pro  Ser Pro Lys Glu Tyr  Lys Lys Gly Asp Thr  Thr Thr Gly 
    1805                 1810                 1815             


Val Tyr  Arg Ile Met Thr Arg  Gly Leu Leu Gly Ser  Tyr Gln Ala 
    1820                 1825                 1830             


Gly Ala  Gly Val Met Val Glu  Gly Val Phe His Thr  Leu Trp His 
    1835                 1840                 1845             


Thr Thr  Lys Gly Ala Ala Leu  Met Ser Gly Glu Gly  Arg Leu Asp 
    1850                 1855                 1860             


Pro Tyr  Trp Gly Ser Val Lys  Glu Asp Arg Leu Cys  Tyr Gly Gly 
    1865                 1870                 1875             


Pro Trp  Lys Leu Gln His Lys  Trp Asn Gly Gln Asp  Glu Val Gln 
    1880                 1885                 1890             


Met Ile  Val Val Glu Pro Gly  Arg Asn Val Lys Asn  Val Gln Thr 
    1895                 1900                 1905             


Lys Pro  Gly Val Phe Lys Thr  Pro Glu Gly Glu Ile  Gly Ala Val 
    1910                 1915                 1920             


Thr Leu  Asp Phe Pro Thr Gly  Thr Ser Gly Ser Pro  Ile Val Asp 
    1925                 1930                 1935             


Lys Asn  Gly Asp Val Ile Gly  Leu Tyr Gly Asn Gly  Val Ile Met 
    1940                 1945                 1950             


Pro Asn  Gly Ser Tyr Ile Ser  Ala Ile Val Gln Gly  Glu Arg Met 
    1955                 1960                 1965             


Asp Glu  Pro Ile Pro Ala Gly  Phe Glu Pro Glu Met  Leu Arg Lys 
    1970                 1975                 1980             


Lys Gln  Ile Thr Val Leu Asp  Leu His Pro Gly Ala  Gly Lys Thr 
    1985                 1990                 1995             


Arg Arg  Ile Leu Pro Gln Ile  Ile Lys Glu Ala Ile  Asn Arg Arg 
    2000                 2005                 2010             


Leu Arg  Thr Ala Val Leu Ala  Pro Thr Arg Val Val  Ala Ala Glu 
    2015                 2020                 2025             


Met Ala  Glu Ala Leu Arg Gly  Leu Pro Ile Arg Tyr  Gln Thr Ser 
    2030                 2035                 2040             


Ala Val  Pro Arg Glu His Asn  Gly Asn Glu Ile Val  Asp Val Met 
    2045                 2050                 2055             


Cys His  Ala Thr Leu Thr His  Arg Leu Met Ser Pro  His Arg Val 
    2060                 2065                 2070             


Pro Asn  Tyr Asn Leu Phe Val  Met Asp Glu Ala His  Phe Thr Asp 
    2075                 2080                 2085             


Pro Ala  Ser Ile Ala Ala Arg  Gly Tyr Ile Ser Thr  Lys Val Glu 
    2090                 2095                 2100             


Leu Gly  Glu Ala Ala Ala Ile  Phe Met Thr Ala Thr  Pro Pro Gly 
    2105                 2110                 2115             


Thr Ser  Asp Pro Phe Pro Glu  Ser Asn Ser Pro Ile  Ser Asp Leu 
    2120                 2125                 2130             


Gln Thr  Glu Ile Pro Asp Arg  Ala Trp Asn Ser Gly  Tyr Glu Trp 
    2135                 2140                 2145             


Ile Thr  Glu Tyr Thr Gly Lys  Thr Val Trp Phe Val  Pro Ser Val 
    2150                 2155                 2160             


Lys Met  Gly Asn Glu Ile Ala  Leu Cys Leu Gln Arg  Ala Gly Lys 
    2165                 2170                 2175             


Lys Val  Val Gln Leu Asn Arg  Lys Ser Tyr Glu Thr  Glu Tyr Pro 
    2180                 2185                 2190             


Lys Cys  Lys Asn Asp Asp Trp  Asp Phe Val Ile Thr  Thr Asp Ile 
    2195                 2200                 2205             


Ser Glu  Met Gly Ala Asn Phe  Lys Ala Ser Arg Val  Ile Asp Ser 
    2210                 2215                 2220             


Arg Lys  Ser Val Lys Pro Thr  Ile Ile Thr Glu Gly  Glu Gly Arg 
    2225                 2230                 2235             


Val Ile  Leu Gly Glu Pro Ser  Ala Val Thr Ala Ala  Ser Ala Ala 
    2240                 2245                 2250             


Gln Arg  Arg Gly Arg Ile Gly  Arg Asn Pro Ser Gln  Val Gly Asp 
    2255                 2260                 2265             


Glu Tyr  Cys Tyr Gly Gly His  Thr Asn Glu Asp Asp  Ser Asn Phe 
    2270                 2275                 2280             


Ala His  Trp Thr Glu Ala Arg  Ile Met Leu Asp Asn  Ile Asn Met 
    2285                 2290                 2295             


Pro Asn  Gly Leu Ile Ala Gln  Phe Tyr Gln Pro Glu  Arg Glu Lys 
    2300                 2305                 2310             


Val Tyr  Thr Met Asp Gly Glu  Tyr Arg Leu Arg Gly  Glu Glu Arg 
    2315                 2320                 2325             


Lys Asn  Phe Leu Glu Leu Leu  Arg Thr Ala Asp Leu  Pro Val Trp 
    2330                 2335                 2340             


Leu Ala  Tyr Lys Val Ala Ala  Ala Gly Val Ser Tyr  His Asp Arg 
    2345                 2350                 2355             


Arg Trp  Cys Phe Asp Gly Pro  Arg Thr Asn Thr Ile  Leu Glu Asp 
    2360                 2365                 2370             


Asn Asn  Glu Val Glu Val Ile  Thr Lys Leu Gly Glu  Arg Lys Ile 
    2375                 2380                 2385             


Leu Arg  Pro Arg Trp Ile Asp  Ala Arg Val Tyr Ser  Asp His Gln 
    2390                 2395                 2400             


Ala Leu  Lys Ala Phe Lys Asp  Phe Ala Ser Gly Lys  Arg Ser Gln 
    2405                 2410                 2415             


Ile Gly  Leu Ile Glu Val Leu  Gly Lys Met Pro Glu  His Phe Met 
    2420                 2425                 2430             


Gly Lys  Thr Trp Glu Ala Leu  Asp Thr Met Tyr Val  Val Ala Thr 
    2435                 2440                 2445             


Ala Glu  Lys Gly Gly Arg Ala  His Arg Met Ala Leu  Glu Glu Leu 
    2450                 2455                 2460             


Pro Asp  Ala Leu Gln Thr Ile  Ala Leu Ile Ala Leu  Leu Ser Val 
    2465                 2470                 2475             


Met Thr  Met Gly Val Phe Phe  Leu Leu Met Gln Arg  Lys Gly Ile 
    2480                 2485                 2490             


Gly Lys  Ile Gly Leu Gly Gly  Ala Val Leu Gly Val  Ala Thr Phe 
    2495                 2500                 2505             


Phe Cys  Trp Met Ala Glu Val  Pro Gly Thr Lys Ile  Ala Gly Met 
    2510                 2515                 2520             


Leu Leu  Leu Ser Leu Leu Leu  Met Ile Val Leu Ile  Pro Glu Pro 
    2525                 2530                 2535             


Glu Lys  Gln Arg Ser Gln Thr  Asp Asn Gln Leu Ala  Val Phe Leu 
    2540                 2545                 2550             


Ile Cys  Val Met Thr Leu Val  Ser Ala Val Ala Ala  Asn Glu Met 
    2555                 2560                 2565             


Gly Trp  Leu Asp Lys Thr Lys  Ser Asp Ile Ser Ser  Leu Phe Gly 
    2570                 2575                 2580             


Gln Arg  Ile Glu Val Lys Glu  Asn Phe Ser Met Gly  Glu Phe Leu 
    2585                 2590                 2595             


Leu Asp  Leu Arg Pro Ala Thr  Ala Trp Ser Leu Tyr  Ala Val Thr 
    2600                 2605                 2610             


Thr Ala  Val Leu Thr Pro Leu  Leu Lys His Leu Ile  Thr Ser Asp 
    2615                 2620                 2625             


Tyr Ile  Asn Thr Ser Leu Thr  Ser Ile Asn Val Gln  Ala Ser Ala 
    2630                 2635                 2640             


Leu Phe  Thr Leu Ala Arg Gly  Phe Pro Phe Val Asp  Val Gly Val 
    2645                 2650                 2655             


Ser Ala  Leu Leu Leu Ala Ala  Gly Cys Trp Gly Gln  Val Thr Leu 
    2660                 2665                 2670             


Thr Val  Thr Val Thr Ala Ala  Thr Leu Leu Phe Cys  His Tyr Ala 
    2675                 2680                 2685             


Tyr Met  Val Pro Gly Trp Gln  Ala Glu Ala Met Arg  Ser Ala Gln 
    2690                 2695                 2700             


Arg Arg  Thr Ala Ala Gly Ile  Met Lys Asn Ala Val  Val Asp Gly 
    2705                 2710                 2715             


Ile Val  Ala Thr Asp Val Pro  Glu Leu Glu Arg Thr  Thr Pro Ile 
    2720                 2725                 2730             


Met Gln  Lys Lys Val Gly Gln  Ile Met Leu Ile Leu  Val Ser Leu 
    2735                 2740                 2745             


Ala Ala  Val Val Val Asn Pro  Ser Val Lys Thr Val  Arg Glu Ala 
    2750                 2755                 2760             


Gly Ile  Leu Ile Thr Ala Ala  Ala Val Thr Leu Trp  Glu Asn Gly 
    2765                 2770                 2775             


Ala Ser  Ser Val Trp Asn Ala  Thr Thr Ala Ile Gly  Leu Cys His 
    2780                 2785                 2790             


Ile Met  Arg Gly Gly Trp Leu  Ser Cys Leu Ser Ile  Thr Trp Thr 
    2795                 2800                 2805             


Leu Ile  Lys Asn Met Glu Lys  Pro Gly Leu Lys Arg  Gly Gly Ala 
    2810                 2815                 2820             


Lys Gly  Arg Thr Leu Gly Glu  Val Trp Lys Glu Arg  Leu Asn Gln 
    2825                 2830                 2835             


Met Thr  Lys Glu Glu Phe Thr  Arg Tyr Arg Lys Glu  Ala Ile Ile 
    2840                 2845                 2850             


Glu Val  Asp Arg Ser Ala Ala  Lys His Ala Arg Lys  Glu Gly Asn 
    2855                 2860                 2865             


Val Thr  Gly Gly His Pro Val  Ser Arg Gly Thr Ala  Lys Leu Arg 
    2870                 2875                 2880             


Trp Leu  Val Glu Arg Arg Phe  Leu Glu Pro Val Gly  Lys Val Ile 
    2885                 2890                 2895             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Cys Tyr Tyr  Met Ala Thr 
    2900                 2905                 2910             


Gln Lys  Arg Val Gln Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2915                 2920                 2925             


Gly His  Glu Glu Pro Gln Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2930                 2935                 2940             


Val Thr  Met Lys Ser Gly Val  Asp Val Phe Tyr Arg  Pro Ser Glu 
    2945                 2950                 2955             


Cys Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2960                 2965                 2970             


Ala Glu  Val Glu Glu His Arg  Thr Ile Arg Val Leu  Glu Met Val 
    2975                 2980                 2985             


Glu Asp  Trp Leu His Arg Gly  Pro Arg Glu Phe Cys  Val Lys Val 
    2990                 2995                 3000             


Leu Cys  Pro Tyr Met Pro Lys  Val Ile Glu Lys Met  Glu Leu Leu 
    3005                 3010                 3015             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Asn Pro  Leu Ser Arg 
    3020                 3025                 3030             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Arg Ala  Ser Gly Asn 
    3035                 3040                 3045             


Val Val  His Ser Val Asn Met  Thr Ser Gln Val Leu  Leu Gly Arg 
    3050                 3055                 3060             


Met Glu  Lys Arg Thr Trp Lys  Gly Pro Gln Tyr Glu  Glu Asp Val 
    3065                 3070                 3075             


Asn Leu  Gly Ser Gly Thr Arg  Ala Val Gly Lys Pro  Leu Leu Asn 
    3080                 3085                 3090             


Ser Asp  Thr Ser Lys Ile Lys  Asn Arg Ile Glu Arg  Leu Arg Arg 
    3095                 3100                 3105             


Glu Tyr  Ser Ser Thr Trp His  His Asp Glu Asn His  Pro Tyr Arg 
    3110                 3115                 3120             


Thr Trp  Asn Tyr His Gly Ser  Tyr Asp Val Lys Pro  Thr Gly Ser 
    3125                 3130                 3135             


Ala Ser  Ser Leu Val Asn Gly  Val Val Arg Leu Leu  Ser Lys Pro 
    3140                 3145                 3150             


Trp Asp  Thr Ile Thr Asn Val  Thr Thr Met Ala Met  Thr Asp Thr 
    3155                 3160                 3165             


Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr 
    3170                 3175                 3180             


Lys Ala  Pro Glu Pro Pro Glu  Gly Val Lys Tyr Val  Leu Asn Glu 
    3185                 3190                 3195             


Thr Thr  Asn Trp Leu Trp Ala  Phe Leu Ala Arg Glu  Lys Arg Pro 
    3200                 3205                 3210             


Arg Met  Cys Ser Arg Glu Glu  Phe Ile Arg Lys Val  Asn Ser Asn 
    3215                 3220                 3225             


Ala Ala  Leu Gly Ala Met Phe  Glu Glu Gln Asn Gln  Trp Arg Ser 
    3230                 3235                 3240             


Ala Arg  Glu Ala Val Glu Asp  Pro Lys Phe Trp Glu  Met Val Asp 
    3245                 3250                 3255             


Glu Glu  Arg Glu Ala His Leu  Arg Gly Glu Cys His  Thr Cys Ile 
    3260                 3265                 3270             


Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys Pro Gly  Glu Phe Gly 
    3275                 3280                 3285             


Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Phe Met Trp  Leu Gly Ala 
    3290                 3295                 3300             


Arg Phe  Leu Glu Phe Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His 
    3305                 3310                 3315             


Trp Leu  Gly Arg Lys Asn Ser  Gly Gly Gly Val Glu  Gly Leu Gly 
    3320                 3325                 3330             


Leu Gln  Lys Leu Gly Tyr Ile  Leu Arg Glu Val Gly  Thr Arg Pro 
    3335                 3340                 3345             


Gly Gly  Lys Ile Tyr Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg 
    3350                 3355                 3360             


Ile Thr  Arg Ala Asp Leu Glu  Asn Glu Ala Lys Val  Leu Glu Leu 
    3365                 3370                 3375             


Leu Asp  Gly Glu His Arg Arg  Leu Ala Arg Ala Ile  Ile Glu Leu 
    3380                 3385                 3390             


Thr Tyr  Arg His Lys Val Val  Lys Val Met Arg Pro  Ala Ala Asp 
    3395                 3400                 3405             


Gly Arg  Thr Val Met Asp Val  Ile Ser Arg Glu Asp  Gln Arg Gly 
    3410                 3415                 3420             


Ser Gly  Gln Val Val Thr Tyr  Ala Leu Asn Thr Phe  Thr Asn Leu 
    3425                 3430                 3435             


Ala Val  Gln Leu Val Arg Met  Met Glu Gly Glu Gly  Val Ile Gly 
    3440                 3445                 3450             


Pro Asp  Asp Val Glu Lys Leu  Thr Lys Gly Lys Gly  Pro Lys Val 
    3455                 3460                 3465             


Arg Thr  Trp Leu Phe Glu Asn  Gly Glu Glu Arg Leu  Ser Arg Met 
    3470                 3475                 3480             


Ala Val  Ser Gly Asp Asp Cys  Val Val Lys Pro Leu  Asp Asp Arg 
    3485                 3490                 3495             


Phe Ala  Thr Ser Leu His Phe  Leu Asn Ala Met Ser  Lys Val Arg 
    3500                 3505                 3510             


Lys Asp  Ile Gln Glu Trp Lys  Pro Ser Thr Gly Trp  Tyr Asp Trp 
    3515                 3520                 3525             


Gln Gln  Val Pro Phe Cys Ser  Asn His Phe Thr Glu  Leu Ile Met 
    3530                 3535                 3540             


Lys Asp  Gly Arg Thr Leu Val  Val Pro Cys Arg Gly  Gln Asp Glu 
    3545                 3550                 3555             


Leu Val  Gly Arg Ala Arg Ile  Ser Pro Gly Ala Gly  Trp Asn Val 
    3560                 3565                 3570             


Arg Asp  Thr Ala Cys Leu Ala  Lys Ser Tyr Ala Gln  Met Trp Leu 
    3575                 3580                 3585             


Leu Leu  Tyr Phe His Arg Arg  Asp Leu Arg Leu Met  Ala Asn Ala 
    3590                 3595                 3600             


Ile Cys  Ser Ala Val Pro Val  Asn Trp Val Pro Thr  Gly Arg Thr 
    3605                 3610                 3615             


Thr Trp  Ser Ile His Ala Gly  Gly Glu Trp Met Thr  Thr Glu Asp 
    3620                 3625                 3630             


Met Leu  Glu Val Trp Asn Arg  Val Trp Ile Glu Glu  Asn Glu Trp 
    3635                 3640                 3645             


Met Glu  Asp Lys Thr Pro Val  Glu Lys Trp Ser Asp  Val Pro Tyr 
    3650                 3655                 3660             


Ser Gly  Lys Arg Glu Asp Ile  Trp Cys Gly Ser Leu  Ile Gly Thr 
    3665                 3670                 3675             


Arg Ala  Arg Ala Thr Trp Ala  Glu Asn Ile Gln Val  Ala Ile Asn 
    3680                 3685                 3690             


Gln Val  Arg Ala Ile Ile Gly  Asp Glu Lys Tyr Val  Asp Tyr Met 
    3695                 3700                 3705             


Ser Ser  Leu Lys Arg Tyr Glu  Asp Thr Thr Leu Val  Glu Asp Thr 
    3710                 3715                 3720             


Val Leu  
    3725 


<210>  11
<211>  11905
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc      120

ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt      180

ggactgaaga gggctatgtt gatggcccag tccaagcacg gcctgaccaa ggagatgacc      240

atgaagtacc gcatggaggg ctgcgtggac ggccacaagt tcgtgatcac cggcgagggc      300

atcggctacc ccttcaaggg caagcaggcc atcaacctgt gcgtggtgga gggcggcccc      360

ttgcccttcg ccgaggacat cttgtccgcc gccttcatgt acggcaaccg cgtgttcacc      420

gagtaccccc aggacatcgt cgactacttc aagaactcct gccccgcagg ctacacctgg      480

gaccgctcct tcctgttcga ggacggcgcc gtgtgcatct gcaacgccga catcaccgtg      540

agcgtggagg agaactgcat gtaccacgag tccaagttct acggcgtgaa cttccccgcc      600

gacggccccg tgatgaagaa gatgaccgac aactgggagc cctcctgcga gaagatcatc      660

cccgtgccca agcagggcat cttgaagggc gacgtgagca tgtacctgct gctgaaggac      720

ggtggccgct tgcgctgcca gttcgacacc gtgtacaagg ccaagtccgt gccccgcaag      780

atgcccgact ggcacttcat ccagcacaag ctgacccgcg aggaccgcag cgacgccaag      840

aaccagaagt ggcacctgac cgagcacgcc atcgcctccg gctccgcctt gcccggaagc      900

ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct      960

atgtccaaaa agcccggcgg tcctgggaaa tccagagccg tgaacatgtt gaaaaggggg     1020

atgccacggg tactgagtct gatcggcctc aaaagagcca tgttgagcct gatcgacggc     1080

aaggggccaa tacgatttgt gttggctctc ttggcgttct tcaggttcac agcaattgct     1140

ccgacccgag cagtgctgga tcgatggaga ggtgtgaaca aacaaacagc gatgaaacac     1200

cttctgagtt ttaagaagga actagggacc ttgaccagtg ctatcaatcg gcggagttcg     1260

aaacaaaaga aaagaggagg aaagaccgga attgcagtca tgattggcct gatcgccagc     1320

gctatggcag cggaggtcac tagacgtggg agtgcatact atatgtactt ggacagaaac     1380

gatgctgggg aggccatatc ttttccaacc acattgggga tgaataagtg ttatatacag     1440

atcatggatc ttggacacat gtgtgatgcc accatgagct atgaatgccc tatgctggat     1500

gagggggtgg aaccagatga cgtcgattgt tggtgcaaca cgacgtcaac ttgggttgtg     1560

tacggaacct gccatcacaa aaaaggtgaa gcacggagaa gtagaagagc tgtgacgctc     1620

ccctcccatt ccactaggaa gctgcaaacg cggtcgcaaa cctggttgga atcaagagaa     1680

tacacaaagc acttgattag agtcgaaaat tggatattca ggaaccctgg cttcgcgtta     1740

gcagcagctg ccatcgcttg gcttttggga agctcaacga gccaaaaagt catatacttg     1800

gtcatgatac tgctgattgc cccggcatac agcatcaggt gcataggagt cagcaatagg     1860

gactttgtgg aaggtatgtc aggtgggact tgggttgata ttgtcttgga acatggaggt     1920

tgtgtcaccg taatggcaca ggacaaaccg actgtcgaca tagagctggt tacaacaaca     1980

gtcagcaaca tggcggaggt aagatcctac tgctatgagg catcaatatc agacatggct     2040

tcggacagcc gctgcccaac acaaggtgaa gcctaccttg acaagcaatc agacactcaa     2100

tatgtctgca aaagaacgtt agtggacaga ggctggggaa atggatgtgg actttttggc     2160

aaagggagtc tggtgacatg cgctaagttt gcatgctcca agaaaatgac cgggaagagc     2220

atccagccag agaatctgga gtaccggata atgctgtcag ttcatggctc ccagcacagt     2280

gggatgatcg ttaatgacac aggacatgaa actgatgaga atagagcgaa ggttgagata     2340

acgcccaatt caccaagagc cgaagccacc ctggggggtt ttggaagcct aggacttgat     2400

tgtgaaccga ggacaggcct tgacttttca gatttgtatt acttgactat gaataacaag     2460

cactggttgg ttcacaagga gtggttccac gacattccat taccttggca cgctggggca     2520

gacaccggaa ctccacactg gaacaacaaa gaagcactgg tagagttcaa ggacgcacat     2580

gccaaaaggc aaactgtcgt ggttctaggg agtcaagaag gagcagttca cacggccctt     2640

gctggagctc tggaggctga gatggatggt gcaaagggaa ggctgtcctc tggccacttg     2700

aaatgtcgcc tgaaaatgga taaacttaga ttgaagggcg tgtcatactc cttgtgtacc     2760

gcagcgttca cattcaccaa gatcccggct gaaacactgc acgggacagt cacagtggag     2820

gtacagtacg cagggacaga tggaccttgc aaggttccag ctcagatggc ggtggacatg     2880

caaactctga ccccagttgg gaggttgata accgctaacc ccgtaatcac tgaaagcact     2940

gagaactcta agatgatgct ggaacttgat ccaccatttg gggactctta cattgtcata     3000

ggagtcgggg agaagaagat cacccaccac tggcacagga gtggcagcac cattggaaaa     3060

gcatttgaag ccactgtgag aggtgccaag agaatggcag tcttgggaga cacagcctgg     3120

gactttggat cagttggagg cgctctcaac tcattgggca agggcatcca tcaaattttt     3180

ggagcagctt tcaaatcatt gtttggagga atgtcctggt tctcacaaat tctcattgga     3240

acgttgctga tgtggttggg tctgaacaca aagaatggat ctatttccct tatgtgcttg     3300

gccttagggg gagtgttgat cttcttatcc acagccgtct ctgctgattc cggatgtgcc     3360

atagacatca gccggcaaga gctgagatgt ggaagtggag tgttcataca caatgatgtg     3420

gaggcttgga tggaccggta caagtattac cctgaaacgc cacaaggcct agccaagatc     3480

attcagaaag ctcataagga aggagtgtgc ggtctacgat cagtttccag actggagcat     3540

caaatgtggg aagcagtgaa ggacgagctg aacactcttt tgaaggagaa tggtgtggac     3600

cttagtgtcg tggttgagaa acaggaggga atgtacaagt cagcacctaa acgcctcacc     3660

gccaccacgg aaaaattgga aattggctgg aaggcctggg gaaagagtat tttatttgca     3720

ccagaactcg ccaacaacac ctttgtggtt gatggtccgg agaccaagga atgtccgact     3780

cagaatcgcg cttggaatag cttagaagtg gaggattttg gatttggtct caccagcact     3840

cggatgttcc tgaaggtcag agagagcaac acaactgaat gtgactcgaa gatcattgga     3900

acggctgtca agaacaactt ggcgatccac agtgacctgt cctattggat tgaaagcagg     3960

ctcaatgata cgtggaagct tgaaagggca gttctgggtg aagtcaaatc atgtacgtgg     4020

cctgagacgc ataccttgtg gggcgatgga atccttgaga gtgacttgat aataccagtc     4080

acactggcgg gaccacgaag caatcacaat cggagacctg ggtacaagac acaaaaccag     4140

ggcccatggg acgaaggccg ggtagagatt gacttcgatt actgcccagg aactacggtc     4200

accctgagtg agagctgcgg acaccgtgga cctgccactc gcaccaccac agagagcgga     4260

aagttgataa cagattggtg ctgcaggagc tgcaccttac caccactgcg ctaccaaact     4320

gacagcggct gttggtatgg tatggagatc agaccacaga gacatgatga aaagaccctc     4380

gtgcagtcac aagtgaatgc ttataatgct gatatgattg acccttttca gttgggcctt     4440

ctggtcgtgt tcttggccac ccaggaggtc cttcgcaaga ggtggacagc caagatcagc     4500

atgccagcta tactgattgc tctgctagtc ctggtgtttg ggggcattac ttacactgat     4560

gtgttacgct atgtcatctt ggtgggggca gctttcgcag aatctaattc gggaggagac     4620

gtggtacact tggcgctcat ggcgaccttc aagatacaac cagtgtttat ggtggcatcg     4680

tttctcaaag cgagatggac caaccaggag aacattttgt tgatgttggc ggctgttttc     4740

tttcaaatgg cttattacga tgcccgccaa attctgctct gggagatccc tgatgtgttg     4800

aattcactgg cggtagcttg gatgatactg agagccataa cattcacaac gacatcaaac     4860

gtggttgttc cgctgctagc cctgctaaca cccgggctga gatgcttgaa tctggatgtg     4920

tacaggatac tgctgttgat ggtcggaata ggcagcttga tcagggagaa gaggagtgca     4980

gctgcaaaaa agaaaggagc aagtctgcta tgcttggctc tagcctcaac aggacttttc     5040

aaccccatga tccttgctgc tggactgatt gcatgtgatc ccaaccgtaa acgcggatgg     5100

cccgcaactg aagtgatgac agctgtcggc ctaatgtttg ccatcgtcgg agggctggca     5160

gagcttgaca ttgactccat ggccattcca atgactatcg cggggctcat gtttgctgct     5220

ttcgtgattt ctgggaaatc aacagatatg tggattgaga gaacggcgga catttcctgg     5280

gaaagtgatg cagaaattac aggctcgagc gaaagagttg atgtgcggct tgatgatgat     5340

ggaaacttcc agctcatgaa tgatccagga gcaccttgga agatatggat gctcagaatg     5400

gtctgtctcg cgattagtgc gtacaccccc tgggcaatct tgccctcagt agttggattt     5460

tggataactc tccaatacac aaagagagga ggcgtgttgt gggacactcc ctcaccaaag     5520

gagtacaaaa agggggacac gaccaccggc gtctacagga tcatgactcg tgggctgctc     5580

ggcagttatc aagcaggagc gggcgtgatg gttgaaggtg ttttccacac cctttggcat     5640

acaacaaaag gagccgcttt gatgagcgga gagggccgcc tggacccata ctggggcagt     5700

gtcaaggagg atcgactttg ttacggagga ccctggaaat tgcagcacaa gtggaacggg     5760

caggatgagg tgcagatgat tgtggtggaa cctggcagga acgttaagaa cgtccagacg     5820

aaaccagggg tgttcaaaac acctgaagga gaaatcgggg ccgtgacttt ggacttcccc     5880

actggaacat caggctcacc aatagtggac aaaaacggtg atgtgattgg gctttatggc     5940

aatggagtca taatgcccaa cggctcatac ataagcgcga tagtgcaggg tgaaaggatg     6000

gatgagccaa tcccagccgg attcgaacct gagatgctga ggaaaaaaca gatcactgta     6060

ctggatctcc atcccggcgc cggtaaaaca aggaggattc tgccacagat catcaaagag     6120

gccataaaca gaagactgag aacagccgtg ctagcaccaa ccagggttgt ggctgctgag     6180

atggctgaag cactgagagg actgcccatc cggtaccaga catccgcagt gcccagagaa     6240

cataatggaa atgagattgt tgatgtcatg tgtcatgcta ccctcaccca caggctgatg     6300

tctcctcaca gggtgccgaa ctacaacctg ttcgtgatgg atgaggctca tttcaccgac     6360

ccagctagca ttgcagcaag aggttacatt tccacaaagg tcgagctagg ggaggcggcg     6420

gcaatattca tgacagccac cccaccaggc acttcagatc cattcccaga gtccaattca     6480

ccaatttccg acttacagac tgagatcccg gatcgagctt ggaactctgg atacgaatgg     6540

atcacagaat acaccgggaa gacggtttgg tttgtgccta gtgtcaagat ggggaatgag     6600

attgcccttt gcctacaacg tgctggaaag aaagtagtcc aattgaacag aaagtcgtac     6660

gagacggagt acccaaaatg taagaacgat gattgggact ttgttatcac aacagacata     6720

tctgaaatgg gggctaactt caaggcgagc agggtgattg acagccggaa gagtgtgaaa     6780

ccaaccatca taacagaagg agaagggaga gtgatcctgg gagaaccatc tgcagtgaca     6840

gcagctagtg ccgcccagag acgtggacgt atcggtagaa atccgtcgca agttggtgat     6900

gagtactgtt atggggggca cacgaatgaa gacgactcga acttcgccca ttggactgag     6960

gcacgaatca tgctggacaa catcaacatg ccaaacggac tgatcgctca attctaccaa     7020

ccagagcgtg agaaggtata taccatggat ggggaatacc ggctcagagg agaagagaga     7080

aaaaactttc tggaactgtt gaggactgca gatctgccag tttggctggc ttacaaggtt     7140

gcagcggctg gagtgtcata ccacgaccgg aggtggtgct ttgatggtcc taggacaaac     7200

acaattttag aagacaacaa cgaagtggaa gtcatcacga agcttggtga aaggaagatt     7260

ctgaggccgc gctggattga cgccagggtg tactcggatc accaggcact aaaggcgttc     7320

aaggacttcg cctcgggaaa acgttctcag atagggctca ttgaggttct gggaaagatg     7380

cctgagcact tcatggggaa gacatgggaa gcacttgaca ccatgtacgt tgtggccact     7440

gcagagaaag gaggaagagc tcacagaatg gccctggagg aactgccaga tgctcttcag     7500

acaattgcct tgattgcctt attgagtgtg atgaccatgg gagtattctt cctcctcatg     7560

cagcggaagg gcattggaaa gataggtttg ggaggcgctg tcttgggagt cgcgaccttt     7620

ttctgttgga tggctgaagt tccaggaacg aagatcgccg gaatgttgct gctctccctt     7680

ctcttgatga ttgtgctaat tcctgagcca gagaagcaac gttcgcagac agacaaccag     7740

ctagccgtgt tcctgatttg tgtcatgacc cttgtgagcg cagtggcagc caacgagatg     7800

ggttggctag ataagaccaa gagtgacata agcagtttgt ttgggcaaag aattgaggtc     7860

aaggagaatt tcagcatggg agagtttctt ttggacttga ggcctgcaac agcctggtca     7920

ctgtacgctg tgacaacagc ggtcctcact ccactgctaa agcatttgat cacgtcagat     7980

tacatcaaca cctcattgac ctcaataaac gttcaggcaa gtgcactatt cacactcgcg     8040

cgaggcttcc ccttcgtcga tgttggagtg tcggctctcc tgctagcagc cggatgctgg     8100

ggacaagtca ccctcaccgt tacggtaaca gcggcaacac tccttttttg ccactatgcc     8160

tacatggttc ccggttggca agctgaggca atgcgctcag cccagcggcg gacagcggcc     8220

ggaatcatga agaacgctgt agtggatggc atcgtggcca cggacgtccc agaattagag     8280

cgcaccacac ccatcatgca gaagaaagtt ggacagatca tgctgatctt ggtgtctcta     8340

gctgcagtag tagtgaaccc gtctgtgaag acagtacgag aagccggaat tttgatcacg     8400

gccgcagcgg tgacgctttg ggagaatgga gcaagctctg tttggaacgc aacaactgcc     8460

atcggactct gccacatcat gcgtgggggt tggttgtcat gtctatccat aacatggaca     8520

ctcataaaga acatggaaaa accaggacta aaaagaggtg gggcaaaagg acgcaccttg     8580

ggagaggttt ggaaagaaag actcaaccag atgacaaaag aagagttcac taggtaccgc     8640

aaagaggcca tcatcgaagt cgatcgctca gcggcaaaac acgccaggaa agaaggcaat     8700

gtcactggag ggcatccagt ctctaggggc acagcaaaac tgagatggct ggtcgaacgg     8760

aggtttctcg aaccggtcgg aaaagtgatt gaccttggat gtggaagagg cggttggtgt     8820

tactatatgg caacccaaaa aagagtccaa gaagtcagag ggtacacaaa gggcggtccc     8880

ggacatgaag agccccaact agtgcaaagt tatggatgga acattgtcac catgaagagt     8940

ggagtggatg tgttctacag accttctgag tgttgtgaca ccctcctttg tgacatcgga     9000

gagtcctcgt caagtgctga ggttgaagag cataggacga ttcgggtcct tgaaatggtt     9060

gaggactggc tgcaccgagg gccaagggaa ttttgcgtga aggtgctctg cccctacatg     9120

ccgaaagtca tagagaagat ggagctgctc caacgccggt atgggggggg actggtcaga     9180

aacccactct cacggaattc cacgcacgag atgtattggg tgagtcgagc ttcaggcaat     9240

gtggtacatt cagtgaatat gaccagccag gtgctcctag gaagaatgga aaaaaggacc     9300

tggaagggac cccaatacga ggaagatgta aacttgggaa gtggaaccag ggcggtggga     9360

aaacccctgc tcaactcaga caccagtaaa atcaagaaca ggattgaacg actcaggcgt     9420

gagtacagtt cgacgtggca ccacgatgag aaccacccat atagaacctg gaactatcac     9480

ggcagttatg atgtgaagcc cacaggctcc gccagttcgc tggtcaatgg agtggtcagg     9540

ctcctctcaa aaccatggga caccatcacg aatgttacca ccatggccat gactgacact     9600

actcccttcg ggcagcagcg agtgttcaaa gagaaggtgg acacgaaagc tcctgaaccg     9660

ccagaaggag tgaagtacgt gctcaacgag accaccaact ggttgtgggc gtttttggcc     9720

agagaaaaac gtcccagaat gtgctctcga gaggaattca taagaaaggt caacagcaat     9780

gcagctttgg gtgccatgtt tgaagagcag aatcaatgga ggagcgccag agaagcagtt     9840

gaagatccaa aattttggga gatggtggat gaggagcgcg aggcacatct gcggggggaa     9900

tgtcacactt gcatttacaa catgatggga aagagagaga aaaaacccgg agagttcgga     9960

aaggccaagg gaagcagagc catttggttc atgtggctcg gagctcgctt tctggagttc    10020

gaggctctgg gttttctcaa tgaagaccac tggcttggaa gaaagaactc aggaggaggt    10080

gtcgagggct tgggcctcca aaaactgggt tacatcctgc gtgaagttgg cacccggcct    10140

gggggcaaga tctatgctga tgacacagct ggctgggaca cccgcatcac gagagctgac    10200

ttggaaaatg aagctaaggt gcttgagctg cttgatgggg aacatcggcg tcttgccagg    10260

gccatcattg agctcaccta tcgtcacaaa gttgtgaaag tgatgcgccc ggctgctgat    10320

ggaagaaccg tcatggatgt tatctccaga gaagatcaga gggggagtgg acaagttgtc    10380

acctacgccc taaacacttt caccaacctg gccgtccagc tggtgaggat gatggaaggg    10440

gaaggagtga ttggcccaga tgatgtggag aaactcacaa aagggaaagg acccaaagtc    10500

aggacctggc tgtttgagaa tggggaagaa agactcagcc gcatggctgt cagtggagat    10560

gactgtgtgg taaagcccct ggacgatcgc tttgccacct cgctccactt cctcaatgct    10620

atgtcaaagg ttcgcaaaga catccaagag tggaaaccgt caactggatg gtatgattgg    10680

cagcaggttc cattttgctc aaaccatttc actgaattga tcatgaaaga tggaagaaca    10740

ctggtggttc catgccgagg acaggatgaa ttggtaggca gagctcgcat atctccaggg    10800

gccggatgga acgtccgcga cactgcttgt ctggctaagt cttatgccca gatgtggctg    10860

cttctgtact tccacagaag agacctgcgg ctcatggcca acgccatttg ctccgctgtc    10920

cctgtgaatt gggtccctac cggaagaacc acgtggtcca tccatgcagg aggagagtgg    10980

atgacaacag aggacatgtt ggaggtctgg aaccgtgttt ggatagagga gaatgaatgg    11040

atggaagaca aaaccccagt ggagaaatgg agtgacgtcc catattcagg aaaacgagag    11100

gacatctggt gtggcagcct gattggcaca agagcccgag ccacgtgggc agaaaacatc    11160

caggtggcta tcaaccaagt cagagcaatc atcggagatg agaagtatgt ggattacatg    11220

agttcactaa agagatatga agacacaact ttggttgagg acacagtact gtagatattt    11280

aatcaattgt aaatagacaa tataagtatg cataaaagtg tagttttata gtagtattta    11340

gtggtgttag tgtaaatagt taagaaaatt ttgaggagaa agtcaggccg ggaagttccc    11400

gccaccggaa gttgagtaga cggtgctgcc tgcgactcaa ccccaggagg actgggtgaa    11460

caaagccgcg aagtgatcca tgtaagccct cagaaccgtc tcggaaggag gaccccacat    11520

gttgtaactt caaagcccaa tgtcagacca cgctacggcg tgctactctg cggagagtgc    11580

agtctgcgat agtgccccag gaggactggg ttaacaaagg caaaccaacg ccccacgcgg    11640

ccctagcccc ggtaatggtg ttaaccaggg cgaaaggact agaggttaga ggagaccccg    11700

cggtttaaag tgcacggccc agcctggctg aagctgtagg tcaggggaag gactagaggt    11760

tagtggagac cccgtgccac aaaacaccac aacaaaacag catattgaca cctgggatag    11820

actaggagat cttctgctct gcacaaccag ccacacggca cagtgcgccg acaatggtgg    11880

ctggtggtgc gagaacacag gatct                                          11905


<210>  12
<211>  3725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Met Ala Gln Ser Lys His Gly Leu Thr Lys Glu Met Thr 
        35                  40                  45              


Met Lys Tyr Arg Met Glu Gly Cys Val Asp Gly His Lys Phe Val Ile 
    50                  55                  60                  


Thr Gly Glu Gly Ile Gly Tyr Pro Phe Lys Gly Lys Gln Ala Ile Asn 
65                  70                  75                  80  


Leu Cys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Glu Asp Ile Leu 
                85                  90                  95      


Ser Ala Ala Phe Met Tyr Gly Asn Arg Val Phe Thr Glu Tyr Pro Gln 
            100                 105                 110         


Asp Ile Val Asp Tyr Phe Lys Asn Ser Cys Pro Ala Gly Tyr Thr Trp 
        115                 120                 125             


Asp Arg Ser Phe Leu Phe Glu Asp Gly Ala Val Cys Ile Cys Asn Ala 
    130                 135                 140                 


Asp Ile Thr Val Ser Val Glu Glu Asn Cys Met Tyr His Glu Ser Lys 
145                 150                 155                 160 


Phe Tyr Gly Val Asn Phe Pro Ala Asp Gly Pro Val Met Lys Lys Met 
                165                 170                 175     


Thr Asp Asn Trp Glu Pro Ser Cys Glu Lys Ile Ile Pro Val Pro Lys 
            180                 185                 190         


Gln Gly Ile Leu Lys Gly Asp Val Ser Met Tyr Leu Leu Leu Lys Asp 
        195                 200                 205             


Gly Gly Arg Leu Arg Cys Gln Phe Asp Thr Val Tyr Lys Ala Lys Ser 
    210                 215                 220                 


Val Pro Arg Lys Met Pro Asp Trp His Phe Ile Gln His Lys Leu Thr 
225                 230                 235                 240 


Arg Glu Asp Arg Ser Asp Ala Lys Asn Gln Lys Trp His Leu Thr Glu 
                245                 250                 255     


His Ala Ile Ala Ser Gly Ser Ala Leu Pro Gly Ser Gly Ala Thr Asn 
            260                 265                 270         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        275                 280                 285             


Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
    290                 295                 300                 


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
305                 310                 315                 320 


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
                325                 330                 335     


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
            340                 345                 350         


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
        355                 360                 365             


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
    370                 375                 380                 


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala 
385                 390                 395                 400 


Val Met Ile Gly Leu Ile Ala Ser Ala Met Ala Ala Glu Val Thr Arg 
                405                 410                 415     


Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu 
            420                 425                 430         


Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln 
        435                 440                 445             


Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys 
    450                 455                 460                 


Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys 
465                 470                 475                 480 


Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys 
                485                 490                 495     


Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser 
            500                 505                 510         


Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu 
        515                 520                 525             


Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro 
    530                 535                 540                 


Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser 
545                 550                 555                 560 


Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro 
                565                 570                 575     


Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu 
            580                 585                 590         


Gly Met Ser Gly Gly Thr Trp Val Asp Ile Val Leu Glu His Gly Gly 
        595                 600                 605             


Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu 
    610                 615                 620                 


Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr 
625                 630                 635                 640 


Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln 
                645                 650                 655     


Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys 
            660                 665                 670         


Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly 
        675                 680                 685             


Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met 
    690                 695                 700                 


Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu 
705                 710                 715                 720 


Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly 
                725                 730                 735     


His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser 
            740                 745                 750         


Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp 
        755                 760                 765             


Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr 
    770                 775                 780                 


Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile 
785                 790                 795                 800 


Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn 
                805                 810                 815     


Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln 
            820                 825                 830         


Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu 
        835                 840                 845             


Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser 
    850                 855                 860                 


Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys 
865                 870                 875                 880 


Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile 
                885                 890                 895     


Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala 
            900                 905                 910         


Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met 
        915                 920                 925             


Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile 
    930                 935                 940                 


Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro 
945                 950                 955                 960 


Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr 
                965                 970                 975     


His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala 
            980                 985                 990         


Thr Val Arg Gly Ala Lys Arg Met  Ala Val Leu Gly Asp  Thr Ala Trp 
        995                 1000                 1005             


Asp Phe  Gly Ser Val Gly Gly  Ala Leu Asn Ser Leu  Gly Lys Gly 
    1010                 1015                 1020             


Ile His  Gln Ile Phe Gly Ala  Ala Phe Lys Ser Leu  Phe Gly Gly 
    1025                 1030                 1035             


Met Ser  Trp Phe Ser Gln Ile  Leu Ile Gly Thr Leu  Leu Met Trp 
    1040                 1045                 1050             


Leu Gly  Leu Asn Thr Lys Asn  Gly Ser Ile Ser Leu  Met Cys Leu 
    1055                 1060                 1065             


Ala Leu  Gly Gly Val Leu Ile  Phe Leu Ser Thr Ala  Val Ser Ala 
    1070                 1075                 1080             


Asp Ser  Gly Cys Ala Ile Asp  Ile Ser Arg Gln Glu  Leu Arg Cys 
    1085                 1090                 1095             


Gly Ser  Gly Val Phe Ile His  Asn Asp Val Glu Ala  Trp Met Asp 
    1100                 1105                 1110             


Arg Tyr  Lys Tyr Tyr Pro Glu  Thr Pro Gln Gly Leu  Ala Lys Ile 
    1115                 1120                 1125             


Ile Gln  Lys Ala His Lys Glu  Gly Val Cys Gly Leu  Arg Ser Val 
    1130                 1135                 1140             


Ser Arg  Leu Glu His Gln Met  Trp Glu Ala Val Lys  Asp Glu Leu 
    1145                 1150                 1155             


Asn Thr  Leu Leu Lys Glu Asn  Gly Val Asp Leu Ser  Val Val Val 
    1160                 1165                 1170             


Glu Lys  Gln Glu Gly Met Tyr  Lys Ser Ala Pro Lys  Arg Leu Thr 
    1175                 1180                 1185             


Ala Thr  Thr Glu Lys Leu Glu  Ile Gly Trp Lys Ala  Trp Gly Lys 
    1190                 1195                 1200             


Ser Ile  Leu Phe Ala Pro Glu  Leu Ala Asn Asn Thr  Phe Val Val 
    1205                 1210                 1215             


Asp Gly  Pro Glu Thr Lys Glu  Cys Pro Thr Gln Asn  Arg Ala Trp 
    1220                 1225                 1230             


Asn Ser  Leu Glu Val Glu Asp  Phe Gly Phe Gly Leu  Thr Ser Thr 
    1235                 1240                 1245             


Arg Met  Phe Leu Lys Val Arg  Glu Ser Asn Thr Thr  Glu Cys Asp 
    1250                 1255                 1260             


Ser Lys  Ile Ile Gly Thr Ala  Val Lys Asn Asn Leu  Ala Ile His 
    1265                 1270                 1275             


Ser Asp  Leu Ser Tyr Trp Ile  Glu Ser Arg Leu Asn  Asp Thr Trp 
    1280                 1285                 1290             


Lys Leu  Glu Arg Ala Val Leu  Gly Glu Val Lys Ser  Cys Thr Trp 
    1295                 1300                 1305             


Pro Glu  Thr His Thr Leu Trp  Gly Asp Gly Ile Leu  Glu Ser Asp 
    1310                 1315                 1320             


Leu Ile  Ile Pro Val Thr Leu  Ala Gly Pro Arg Ser  Asn His Asn 
    1325                 1330                 1335             


Arg Arg  Pro Gly Tyr Lys Thr  Gln Asn Gln Gly Pro  Trp Asp Glu 
    1340                 1345                 1350             


Gly Arg  Val Glu Ile Asp Phe  Asp Tyr Cys Pro Gly  Thr Thr Val 
    1355                 1360                 1365             


Thr Leu  Ser Glu Ser Cys Gly  His Arg Gly Pro Ala  Thr Arg Thr 
    1370                 1375                 1380             


Thr Thr  Glu Ser Gly Lys Leu  Ile Thr Asp Trp Cys  Cys Arg Ser 
    1385                 1390                 1395             


Cys Thr  Leu Pro Pro Leu Arg  Tyr Gln Thr Asp Ser  Gly Cys Trp 
    1400                 1405                 1410             


Tyr Gly  Met Glu Ile Arg Pro  Gln Arg His Asp Glu  Lys Thr Leu 
    1415                 1420                 1425             


Val Gln  Ser Gln Val Asn Ala  Tyr Asn Ala Asp Met  Ile Asp Pro 
    1430                 1435                 1440             


Phe Gln  Leu Gly Leu Leu Val  Val Phe Leu Ala Thr  Gln Glu Val 
    1445                 1450                 1455             


Leu Arg  Lys Arg Trp Thr Ala  Lys Ile Ser Met Pro  Ala Ile Leu 
    1460                 1465                 1470             


Ile Ala  Leu Leu Val Leu Val  Phe Gly Gly Ile Thr  Tyr Thr Asp 
    1475                 1480                 1485             


Val Leu  Arg Tyr Val Ile Leu  Val Gly Ala Ala Phe  Ala Glu Ser 
    1490                 1495                 1500             


Asn Ser  Gly Gly Asp Val Val  His Leu Ala Leu Met  Ala Thr Phe 
    1505                 1510                 1515             


Lys Ile  Gln Pro Val Phe Met  Val Ala Ser Phe Leu  Lys Ala Arg 
    1520                 1525                 1530             


Trp Thr  Asn Gln Glu Asn Ile  Leu Leu Met Leu Ala  Ala Val Phe 
    1535                 1540                 1545             


Phe Gln  Met Ala Tyr Tyr Asp  Ala Arg Gln Ile Leu  Leu Trp Glu 
    1550                 1555                 1560             


Ile Pro  Asp Val Leu Asn Ser  Leu Ala Val Ala Trp  Met Ile Leu 
    1565                 1570                 1575             


Arg Ala  Ile Thr Phe Thr Thr  Thr Ser Asn Val Val  Val Pro Leu 
    1580                 1585                 1590             


Leu Ala  Leu Leu Thr Pro Gly  Leu Arg Cys Leu Asn  Leu Asp Val 
    1595                 1600                 1605             


Tyr Arg  Ile Leu Leu Leu Met  Val Gly Ile Gly Ser  Leu Ile Arg 
    1610                 1615                 1620             


Glu Lys  Arg Ser Ala Ala Ala  Lys Lys Lys Gly Ala  Ser Leu Leu 
    1625                 1630                 1635             


Cys Leu  Ala Leu Ala Ser Thr  Gly Leu Phe Asn Pro  Met Ile Leu 
    1640                 1645                 1650             


Ala Ala  Gly Leu Ile Ala Cys  Asp Pro Asn Arg Lys  Arg Gly Trp 
    1655                 1660                 1665             


Pro Ala  Thr Glu Val Met Thr  Ala Val Gly Leu Met  Phe Ala Ile 
    1670                 1675                 1680             


Val Gly  Gly Leu Ala Glu Leu  Asp Ile Asp Ser Met  Ala Ile Pro 
    1685                 1690                 1695             


Met Thr  Ile Ala Gly Leu Met  Phe Ala Ala Phe Val  Ile Ser Gly 
    1700                 1705                 1710             


Lys Ser  Thr Asp Met Trp Ile  Glu Arg Thr Ala Asp  Ile Ser Trp 
    1715                 1720                 1725             


Glu Ser  Asp Ala Glu Ile Thr  Gly Ser Ser Glu Arg  Val Asp Val 
    1730                 1735                 1740             


Arg Leu  Asp Asp Asp Gly Asn  Phe Gln Leu Met Asn  Asp Pro Gly 
    1745                 1750                 1755             


Ala Pro  Trp Lys Ile Trp Met  Leu Arg Met Val Cys  Leu Ala Ile 
    1760                 1765                 1770             


Ser Ala  Tyr Thr Pro Trp Ala  Ile Leu Pro Ser Val  Val Gly Phe 
    1775                 1780                 1785             


Trp Ile  Thr Leu Gln Tyr Thr  Lys Arg Gly Gly Val  Leu Trp Asp 
    1790                 1795                 1800             


Thr Pro  Ser Pro Lys Glu Tyr  Lys Lys Gly Asp Thr  Thr Thr Gly 
    1805                 1810                 1815             


Val Tyr  Arg Ile Met Thr Arg  Gly Leu Leu Gly Ser  Tyr Gln Ala 
    1820                 1825                 1830             


Gly Ala  Gly Val Met Val Glu  Gly Val Phe His Thr  Leu Trp His 
    1835                 1840                 1845             


Thr Thr  Lys Gly Ala Ala Leu  Met Ser Gly Glu Gly  Arg Leu Asp 
    1850                 1855                 1860             


Pro Tyr  Trp Gly Ser Val Lys  Glu Asp Arg Leu Cys  Tyr Gly Gly 
    1865                 1870                 1875             


Pro Trp  Lys Leu Gln His Lys  Trp Asn Gly Gln Asp  Glu Val Gln 
    1880                 1885                 1890             


Met Ile  Val Val Glu Pro Gly  Arg Asn Val Lys Asn  Val Gln Thr 
    1895                 1900                 1905             


Lys Pro  Gly Val Phe Lys Thr  Pro Glu Gly Glu Ile  Gly Ala Val 
    1910                 1915                 1920             


Thr Leu  Asp Phe Pro Thr Gly  Thr Ser Gly Ser Pro  Ile Val Asp 
    1925                 1930                 1935             


Lys Asn  Gly Asp Val Ile Gly  Leu Tyr Gly Asn Gly  Val Ile Met 
    1940                 1945                 1950             


Pro Asn  Gly Ser Tyr Ile Ser  Ala Ile Val Gln Gly  Glu Arg Met 
    1955                 1960                 1965             


Asp Glu  Pro Ile Pro Ala Gly  Phe Glu Pro Glu Met  Leu Arg Lys 
    1970                 1975                 1980             


Lys Gln  Ile Thr Val Leu Asp  Leu His Pro Gly Ala  Gly Lys Thr 
    1985                 1990                 1995             


Arg Arg  Ile Leu Pro Gln Ile  Ile Lys Glu Ala Ile  Asn Arg Arg 
    2000                 2005                 2010             


Leu Arg  Thr Ala Val Leu Ala  Pro Thr Arg Val Val  Ala Ala Glu 
    2015                 2020                 2025             


Met Ala  Glu Ala Leu Arg Gly  Leu Pro Ile Arg Tyr  Gln Thr Ser 
    2030                 2035                 2040             


Ala Val  Pro Arg Glu His Asn  Gly Asn Glu Ile Val  Asp Val Met 
    2045                 2050                 2055             


Cys His  Ala Thr Leu Thr His  Arg Leu Met Ser Pro  His Arg Val 
    2060                 2065                 2070             


Pro Asn  Tyr Asn Leu Phe Val  Met Asp Glu Ala His  Phe Thr Asp 
    2075                 2080                 2085             


Pro Ala  Ser Ile Ala Ala Arg  Gly Tyr Ile Ser Thr  Lys Val Glu 
    2090                 2095                 2100             


Leu Gly  Glu Ala Ala Ala Ile  Phe Met Thr Ala Thr  Pro Pro Gly 
    2105                 2110                 2115             


Thr Ser  Asp Pro Phe Pro Glu  Ser Asn Ser Pro Ile  Ser Asp Leu 
    2120                 2125                 2130             


Gln Thr  Glu Ile Pro Asp Arg  Ala Trp Asn Ser Gly  Tyr Glu Trp 
    2135                 2140                 2145             


Ile Thr  Glu Tyr Thr Gly Lys  Thr Val Trp Phe Val  Pro Ser Val 
    2150                 2155                 2160             


Lys Met  Gly Asn Glu Ile Ala  Leu Cys Leu Gln Arg  Ala Gly Lys 
    2165                 2170                 2175             


Lys Val  Val Gln Leu Asn Arg  Lys Ser Tyr Glu Thr  Glu Tyr Pro 
    2180                 2185                 2190             


Lys Cys  Lys Asn Asp Asp Trp  Asp Phe Val Ile Thr  Thr Asp Ile 
    2195                 2200                 2205             


Ser Glu  Met Gly Ala Asn Phe  Lys Ala Ser Arg Val  Ile Asp Ser 
    2210                 2215                 2220             


Arg Lys  Ser Val Lys Pro Thr  Ile Ile Thr Glu Gly  Glu Gly Arg 
    2225                 2230                 2235             


Val Ile  Leu Gly Glu Pro Ser  Ala Val Thr Ala Ala  Ser Ala Ala 
    2240                 2245                 2250             


Gln Arg  Arg Gly Arg Ile Gly  Arg Asn Pro Ser Gln  Val Gly Asp 
    2255                 2260                 2265             


Glu Tyr  Cys Tyr Gly Gly His  Thr Asn Glu Asp Asp  Ser Asn Phe 
    2270                 2275                 2280             


Ala His  Trp Thr Glu Ala Arg  Ile Met Leu Asp Asn  Ile Asn Met 
    2285                 2290                 2295             


Pro Asn  Gly Leu Ile Ala Gln  Phe Tyr Gln Pro Glu  Arg Glu Lys 
    2300                 2305                 2310             


Val Tyr  Thr Met Asp Gly Glu  Tyr Arg Leu Arg Gly  Glu Glu Arg 
    2315                 2320                 2325             


Lys Asn  Phe Leu Glu Leu Leu  Arg Thr Ala Asp Leu  Pro Val Trp 
    2330                 2335                 2340             


Leu Ala  Tyr Lys Val Ala Ala  Ala Gly Val Ser Tyr  His Asp Arg 
    2345                 2350                 2355             


Arg Trp  Cys Phe Asp Gly Pro  Arg Thr Asn Thr Ile  Leu Glu Asp 
    2360                 2365                 2370             


Asn Asn  Glu Val Glu Val Ile  Thr Lys Leu Gly Glu  Arg Lys Ile 
    2375                 2380                 2385             


Leu Arg  Pro Arg Trp Ile Asp  Ala Arg Val Tyr Ser  Asp His Gln 
    2390                 2395                 2400             


Ala Leu  Lys Ala Phe Lys Asp  Phe Ala Ser Gly Lys  Arg Ser Gln 
    2405                 2410                 2415             


Ile Gly  Leu Ile Glu Val Leu  Gly Lys Met Pro Glu  His Phe Met 
    2420                 2425                 2430             


Gly Lys  Thr Trp Glu Ala Leu  Asp Thr Met Tyr Val  Val Ala Thr 
    2435                 2440                 2445             


Ala Glu  Lys Gly Gly Arg Ala  His Arg Met Ala Leu  Glu Glu Leu 
    2450                 2455                 2460             


Pro Asp  Ala Leu Gln Thr Ile  Ala Leu Ile Ala Leu  Leu Ser Val 
    2465                 2470                 2475             


Met Thr  Met Gly Val Phe Phe  Leu Leu Met Gln Arg  Lys Gly Ile 
    2480                 2485                 2490             


Gly Lys  Ile Gly Leu Gly Gly  Ala Val Leu Gly Val  Ala Thr Phe 
    2495                 2500                 2505             


Phe Cys  Trp Met Ala Glu Val  Pro Gly Thr Lys Ile  Ala Gly Met 
    2510                 2515                 2520             


Leu Leu  Leu Ser Leu Leu Leu  Met Ile Val Leu Ile  Pro Glu Pro 
    2525                 2530                 2535             


Glu Lys  Gln Arg Ser Gln Thr  Asp Asn Gln Leu Ala  Val Phe Leu 
    2540                 2545                 2550             


Ile Cys  Val Met Thr Leu Val  Ser Ala Val Ala Ala  Asn Glu Met 
    2555                 2560                 2565             


Gly Trp  Leu Asp Lys Thr Lys  Ser Asp Ile Ser Ser  Leu Phe Gly 
    2570                 2575                 2580             


Gln Arg  Ile Glu Val Lys Glu  Asn Phe Ser Met Gly  Glu Phe Leu 
    2585                 2590                 2595             


Leu Asp  Leu Arg Pro Ala Thr  Ala Trp Ser Leu Tyr  Ala Val Thr 
    2600                 2605                 2610             


Thr Ala  Val Leu Thr Pro Leu  Leu Lys His Leu Ile  Thr Ser Asp 
    2615                 2620                 2625             


Tyr Ile  Asn Thr Ser Leu Thr  Ser Ile Asn Val Gln  Ala Ser Ala 
    2630                 2635                 2640             


Leu Phe  Thr Leu Ala Arg Gly  Phe Pro Phe Val Asp  Val Gly Val 
    2645                 2650                 2655             


Ser Ala  Leu Leu Leu Ala Ala  Gly Cys Trp Gly Gln  Val Thr Leu 
    2660                 2665                 2670             


Thr Val  Thr Val Thr Ala Ala  Thr Leu Leu Phe Cys  His Tyr Ala 
    2675                 2680                 2685             


Tyr Met  Val Pro Gly Trp Gln  Ala Glu Ala Met Arg  Ser Ala Gln 
    2690                 2695                 2700             


Arg Arg  Thr Ala Ala Gly Ile  Met Lys Asn Ala Val  Val Asp Gly 
    2705                 2710                 2715             


Ile Val  Ala Thr Asp Val Pro  Glu Leu Glu Arg Thr  Thr Pro Ile 
    2720                 2725                 2730             


Met Gln  Lys Lys Val Gly Gln  Ile Met Leu Ile Leu  Val Ser Leu 
    2735                 2740                 2745             


Ala Ala  Val Val Val Asn Pro  Ser Val Lys Thr Val  Arg Glu Ala 
    2750                 2755                 2760             


Gly Ile  Leu Ile Thr Ala Ala  Ala Val Thr Leu Trp  Glu Asn Gly 
    2765                 2770                 2775             


Ala Ser  Ser Val Trp Asn Ala  Thr Thr Ala Ile Gly  Leu Cys His 
    2780                 2785                 2790             


Ile Met  Arg Gly Gly Trp Leu  Ser Cys Leu Ser Ile  Thr Trp Thr 
    2795                 2800                 2805             


Leu Ile  Lys Asn Met Glu Lys  Pro Gly Leu Lys Arg  Gly Gly Ala 
    2810                 2815                 2820             


Lys Gly  Arg Thr Leu Gly Glu  Val Trp Lys Glu Arg  Leu Asn Gln 
    2825                 2830                 2835             


Met Thr  Lys Glu Glu Phe Thr  Arg Tyr Arg Lys Glu  Ala Ile Ile 
    2840                 2845                 2850             


Glu Val  Asp Arg Ser Ala Ala  Lys His Ala Arg Lys  Glu Gly Asn 
    2855                 2860                 2865             


Val Thr  Gly Gly His Pro Val  Ser Arg Gly Thr Ala  Lys Leu Arg 
    2870                 2875                 2880             


Trp Leu  Val Glu Arg Arg Phe  Leu Glu Pro Val Gly  Lys Val Ile 
    2885                 2890                 2895             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Cys Tyr Tyr  Met Ala Thr 
    2900                 2905                 2910             


Gln Lys  Arg Val Gln Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2915                 2920                 2925             


Gly His  Glu Glu Pro Gln Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2930                 2935                 2940             


Val Thr  Met Lys Ser Gly Val  Asp Val Phe Tyr Arg  Pro Ser Glu 
    2945                 2950                 2955             


Cys Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2960                 2965                 2970             


Ala Glu  Val Glu Glu His Arg  Thr Ile Arg Val Leu  Glu Met Val 
    2975                 2980                 2985             


Glu Asp  Trp Leu His Arg Gly  Pro Arg Glu Phe Cys  Val Lys Val 
    2990                 2995                 3000             


Leu Cys  Pro Tyr Met Pro Lys  Val Ile Glu Lys Met  Glu Leu Leu 
    3005                 3010                 3015             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Asn Pro  Leu Ser Arg 
    3020                 3025                 3030             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Arg Ala  Ser Gly Asn 
    3035                 3040                 3045             


Val Val  His Ser Val Asn Met  Thr Ser Gln Val Leu  Leu Gly Arg 
    3050                 3055                 3060             


Met Glu  Lys Arg Thr Trp Lys  Gly Pro Gln Tyr Glu  Glu Asp Val 
    3065                 3070                 3075             


Asn Leu  Gly Ser Gly Thr Arg  Ala Val Gly Lys Pro  Leu Leu Asn 
    3080                 3085                 3090             


Ser Asp  Thr Ser Lys Ile Lys  Asn Arg Ile Glu Arg  Leu Arg Arg 
    3095                 3100                 3105             


Glu Tyr  Ser Ser Thr Trp His  His Asp Glu Asn His  Pro Tyr Arg 
    3110                 3115                 3120             


Thr Trp  Asn Tyr His Gly Ser  Tyr Asp Val Lys Pro  Thr Gly Ser 
    3125                 3130                 3135             


Ala Ser  Ser Leu Val Asn Gly  Val Val Arg Leu Leu  Ser Lys Pro 
    3140                 3145                 3150             


Trp Asp  Thr Ile Thr Asn Val  Thr Thr Met Ala Met  Thr Asp Thr 
    3155                 3160                 3165             


Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr 
    3170                 3175                 3180             


Lys Ala  Pro Glu Pro Pro Glu  Gly Val Lys Tyr Val  Leu Asn Glu 
    3185                 3190                 3195             


Thr Thr  Asn Trp Leu Trp Ala  Phe Leu Ala Arg Glu  Lys Arg Pro 
    3200                 3205                 3210             


Arg Met  Cys Ser Arg Glu Glu  Phe Ile Arg Lys Val  Asn Ser Asn 
    3215                 3220                 3225             


Ala Ala  Leu Gly Ala Met Phe  Glu Glu Gln Asn Gln  Trp Arg Ser 
    3230                 3235                 3240             


Ala Arg  Glu Ala Val Glu Asp  Pro Lys Phe Trp Glu  Met Val Asp 
    3245                 3250                 3255             


Glu Glu  Arg Glu Ala His Leu  Arg Gly Glu Cys His  Thr Cys Ile 
    3260                 3265                 3270             


Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys Pro Gly  Glu Phe Gly 
    3275                 3280                 3285             


Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Phe Met Trp  Leu Gly Ala 
    3290                 3295                 3300             


Arg Phe  Leu Glu Phe Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His 
    3305                 3310                 3315             


Trp Leu  Gly Arg Lys Asn Ser  Gly Gly Gly Val Glu  Gly Leu Gly 
    3320                 3325                 3330             


Leu Gln  Lys Leu Gly Tyr Ile  Leu Arg Glu Val Gly  Thr Arg Pro 
    3335                 3340                 3345             


Gly Gly  Lys Ile Tyr Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg 
    3350                 3355                 3360             


Ile Thr  Arg Ala Asp Leu Glu  Asn Glu Ala Lys Val  Leu Glu Leu 
    3365                 3370                 3375             


Leu Asp  Gly Glu His Arg Arg  Leu Ala Arg Ala Ile  Ile Glu Leu 
    3380                 3385                 3390             


Thr Tyr  Arg His Lys Val Val  Lys Val Met Arg Pro  Ala Ala Asp 
    3395                 3400                 3405             


Gly Arg  Thr Val Met Asp Val  Ile Ser Arg Glu Asp  Gln Arg Gly 
    3410                 3415                 3420             


Ser Gly  Gln Val Val Thr Tyr  Ala Leu Asn Thr Phe  Thr Asn Leu 
    3425                 3430                 3435             


Ala Val  Gln Leu Val Arg Met  Met Glu Gly Glu Gly  Val Ile Gly 
    3440                 3445                 3450             


Pro Asp  Asp Val Glu Lys Leu  Thr Lys Gly Lys Gly  Pro Lys Val 
    3455                 3460                 3465             


Arg Thr  Trp Leu Phe Glu Asn  Gly Glu Glu Arg Leu  Ser Arg Met 
    3470                 3475                 3480             


Ala Val  Ser Gly Asp Asp Cys  Val Val Lys Pro Leu  Asp Asp Arg 
    3485                 3490                 3495             


Phe Ala  Thr Ser Leu His Phe  Leu Asn Ala Met Ser  Lys Val Arg 
    3500                 3505                 3510             


Lys Asp  Ile Gln Glu Trp Lys  Pro Ser Thr Gly Trp  Tyr Asp Trp 
    3515                 3520                 3525             


Gln Gln  Val Pro Phe Cys Ser  Asn His Phe Thr Glu  Leu Ile Met 
    3530                 3535                 3540             


Lys Asp  Gly Arg Thr Leu Val  Val Pro Cys Arg Gly  Gln Asp Glu 
    3545                 3550                 3555             


Leu Val  Gly Arg Ala Arg Ile  Ser Pro Gly Ala Gly  Trp Asn Val 
    3560                 3565                 3570             


Arg Asp  Thr Ala Cys Leu Ala  Lys Ser Tyr Ala Gln  Met Trp Leu 
    3575                 3580                 3585             


Leu Leu  Tyr Phe His Arg Arg  Asp Leu Arg Leu Met  Ala Asn Ala 
    3590                 3595                 3600             


Ile Cys  Ser Ala Val Pro Val  Asn Trp Val Pro Thr  Gly Arg Thr 
    3605                 3610                 3615             


Thr Trp  Ser Ile His Ala Gly  Gly Glu Trp Met Thr  Thr Glu Asp 
    3620                 3625                 3630             


Met Leu  Glu Val Trp Asn Arg  Val Trp Ile Glu Glu  Asn Glu Trp 
    3635                 3640                 3645             


Met Glu  Asp Lys Thr Pro Val  Glu Lys Trp Ser Asp  Val Pro Tyr 
    3650                 3655                 3660             


Ser Gly  Lys Arg Glu Asp Ile  Trp Cys Gly Ser Leu  Ile Gly Thr 
    3665                 3670                 3675             


Arg Ala  Arg Ala Thr Trp Ala  Glu Asn Ile Gln Val  Ala Ile Asn 
    3680                 3685                 3690             


Gln Val  Arg Ala Ile Ile Gly  Asp Glu Lys Tyr Val  Asp Tyr Met 
    3695                 3700                 3705             


Ser Ser  Leu Lys Arg Tyr Glu  Asp Thr Thr Leu Val  Glu Asp Thr 
    3710                 3715                 3720             


Val Leu  
    3725 


<210>  13
<211>  10807
<212>  DNA
<213>  Zika virus strain R103451

<400>  13
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      240

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gtggggaaaa aagaggctat ggaaataata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcgcagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aaacgatgct ggggaggcca      540

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      660

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      720

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacta      780

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      840

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgccatcg      900

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcagacat ggcttcggac agccgctgcc     1200

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1440

acacaggaca tgaaactgat gagaatagag cgaaggttga gataacgccc aattcaccaa     1500

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggttcaca     1620

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1680

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg taccgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2400

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggagtgt     2460

tgatcttctt atccacagcc gtctctgctg atgtggggtg ctcggtggac ttctcaaaga     2520

aggagacgag atgcggtaca ggggtgttcg tctataacga cgttgaagcc tggagggaca     2580

ggtacaagta ccatcctgac tccccccgta gattggcagc agcagtcaag caagcctggg     2640

aagatggtat ctgcgggatc tcctctgttt caagaatgga aaacatcatg tggagatcag     2700

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg     2760

gatctgtaaa aaaccccatg tggagagctc cacagagatt gcccgtgcct gtgaacgagc     2820

tgccccacgg ctggaaggct tgggggaaat cgtacttcgt cagagcagca aagacaaata     2880

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     2940

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     3000

ttagagaaga ttattcatta gagtgtgatc cagccgttat tggaacagct gttaagggaa     3060

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaat gacacatgga     3120

ggctgaagag ggcccatctg atcgagatga aaacatgtga atggccaaag tcccacacat     3180

tgtggacaga tggaatagaa gagagtgatc tgatcatacc caagtcttta gctgggccac     3240

tcagccatca caataccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     3300

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     3360

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3420

ggtgctgcag ggagtgcaca atgcccccac tgtcgttccg ggctaaagat ggctgttggt     3480

atggaatgga gataaggccc aggaaagaac cagaaagcaa cttagtaagg tcaatggtga     3540

ctgcaggatc aactgatcac atggatcact tctcccttgg agtgcttgtg attctgctca     3600

tggtgcagga agggctaaag aagagaatga ccacaaagat catcataagc acatcaatgg     3660

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     3720

ttttgatggg tgccaccttc gcggaaatga acactggagg agatgtagct catctggcgc     3780

tgatagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     3840

ggacaccccg tgaaagcatg ctactggcct tggcctcgtg tcttttgcaa actgcgatct     3900

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3960

tacgagcgat ggttgttcca cgcactgata acatcacctt ggcaatcctg gctgctctga     4020

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4080

ggtttatgct cctctctctg aagggaaaag gcagtgtgaa gaagaactta ccatttgtca     4140

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4200

tgctcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     4260

tgatatgcgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     4320

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4380

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agtcactgga aacagtcccc     4440

ggctcgatgt ggcgctagat gagagtggtg atttctccct ggtggaggat gacggtcccc     4500

ccatgagaga gatcatactc aaggtggtcc tgatgaccat ctgtggcatg aacccaatag     4560

ccataccctt cgcagctgga gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg     4620

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     4680

acagagtaat gactcgtaga ctgctaggtt caacacaagt tggagtggga gttatgcaag     4740

agggggtctt tcacactatg tggcacgtca caaaaggatc cgcactgaga agcggtgaag     4800

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccat     4860

ggaagctaga tgccgcctgg gacgggcaca gcgaggtgca gctcttggcc gtgccccccg     4920

gagagagagc gaggaacatc cagactctgc ccggaatatt taagacaaag gatggggaca     4980

ttggagcggt tgcgctggat tacccagcag gaacttcagg atctccaatc ctagacaagt     5040

gtgggagagt gataggactt tatggcaatg gggtcgtgat caaaaatggg agttatgtta     5100

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccttcga     5160

tgctgaagaa gaagcagcta actgtcttag acttacatcc tggagctggg aaaaccagga     5220

gagttcttcc tgaaatagtc cgtgaagcca taaaaacaag actccgtact gtgatcttag     5280

ctccaaccag ggttgtcgct gctgaaatgg aggaggccct tagagggctt ccagtgcgtt     5340

atatgacaac agcagtcaat gtcacccact ctggaacaga aatcgtcgac ttaatgtgcc     5400

atgccacctt cacttcacgt ctactacagc caatcagagt ccccaactat aatctgtata     5460

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     5520

caagggttga gatgggcgag gcggctgcca tcttcatgac cgccacgcca ccaggaaccc     5580

gtgacgcatt tccggactcc aactcaccaa ttatggacac cgaagtggaa gtcccagaga     5640

gagcctggag ctcaggcttt gattgggtga cggatcattc tggaaaaaca gtttggtttg     5700

ttccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     5760

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacaaaa catcaagagt     5820

gggactttgt cgtgacaact gacatttcag agatgggcgc caactttaaa gctgaccgtg     5880

tcatagattc caggagatgc ctaaagccgg tcatacttga tggcgagaga gtcattctgg     5940

ctggacccat gcctgtcaca catgccagcg ctgcccagag gagggggcgc ataggcagga     6000

atcccaacaa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgacgaag     6060

accatgcaca ctggcttgaa gcaagaatgc tccttgacaa tatttacctc caagatggcc     6120

tcatagcctc gctctatcga cctgaggccg acaaagtagc agccattgag ggagagttca     6180

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttcctg     6240

tttggctggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     6300

ttgatggcac gaccaacaac accatactgg aagacagcgt gccggcagag gtgtggacca     6360

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6420

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6480

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6540

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6600

cccaattgcc ggagacccta gagaccatta tgcttttggg gttgctggga acagtctcgc     6660

tgggaatctt tttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     6720

tgacccttgg ggccagtgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6780

catgcgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6840

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6900

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6960

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     7020

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     7080

atgcagtgac cacttcatac aacaactact ccttaatggc gatggccacg caagctggag     7140

tgttgtttgg tatgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7200

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     7260

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc     7320

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7380

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7440

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7500

gggccctgat cacagccgca acttccactt tgtgggaagg ctctccgaac aagtactgga     7560

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagcct     7620

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7680

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7740

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7800

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7860

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7920

ggggctggag ttactacgcc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7980

aaggaggccc tggtcatgaa gaacccgtgt tggtgcaaag ctatgggtgg aacattgtcc     8040

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgttgctgt     8100

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8160

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8220

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8280

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8340

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8400

acgggcctag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8460

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8520

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8580

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     8640

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8700

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8760

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8820

agctaggcaa acacaaacgg ccacgagtct gtaccaaaga agagttcatc aacaaggttc     8880

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8940

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     9000

gaggagagtg ccagagttgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     9060

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9120

tagagttcga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     9180

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtt     9240

gcataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcatcagca     9300

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     9360

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9420

ctgaaaaagg gaaaacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     9480

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9540

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9600

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9660

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9720

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9780

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     9840

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     9900

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg caaatgtggc     9960

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg    10020

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10080

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10140

acatggaaga caagacccca gttacgaaat ggacagacat tccctatttg ggaaaaaggg    10200

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10260

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10320

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag    10380

caccaatctt aacgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc cccaggagaa gctgggaaac caagcctata gtcaggccga gaacgccatg    10500

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca    10560

cgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg    10620

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggagacc    10680

ccccggaaaa cgcaaaacag catattgacg ctgggaaaga ccagagactc catgagtttc    10740

caccacgctg gccgccaggc acagatcgcc gaatagcggc ggccggtgtg gggaaatcca    10800

tgggtct                                                              10807


<210>  14
<211>  3423
<212>  PRT
<213>  Zika virus strain R103451

<400>  14

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Ala Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Leu Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Cys  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  15
<211>  10807
<212>  DNA
<213>  Zika virus strain PRVABC59

<400>  15
agttgttgat ctgtgtgaat cagactgcga cagttcgagt ttgaagcgaa agctagcaac       60

agtatcaaca ggttttattt tggatttgga aacgagagtt tctggtcatg aaaaacccaa      120

aaaagaaatc cggaggattc cggattgtca atatgctaaa acgcggagta gcccgtgtga      180

gcccctttgg gggcttgaag aggctgccag ccggacttct gctgggtcat gggcccatca      240

ggatggtctt ggcgattcta gcctttttga gattcacggc aatcaagcca tcactgggtc      300

tcatcaatag atggggttca gtggggaaaa aagaggctat ggaaacaata aagaagttca      360

agaaagatct ggctgccatg ctgagaataa tcaatgctag gaaggagaag aagagacgag      420

gcgcagatac tagtgtcgga attgttggcc tcctgctgac cacagctatg gcagcggagg      480

tcactagacg tgggagtgca tactatatgt acttggacag aaacgatgct ggggaggcca      540

tatcttttcc aaccacattg gggatgaata agtgttatat acagatcatg gatcttggac      600

acatgtgtga tgccaccatg agctatgaat gccctatgct ggatgagggg gtggaaccag      660

atgacgtcga ttgttggtgc aacacgacgt caacttgggt tgtgtacgga acctgccatc      720

acaaaaaagg tgaagcacgg agatctagaa gagctgtgac gctcccctcc cattccacca      780

ggaagctgca aacgcggtcg caaacctggt tggaatcaag agaatacaca aagcacttga      840

ttagagtcga aaattggata ttcaggaacc ctggcttcgc gttagcagca gctgccatcg      900

cttggctttt gggaagctca acgagccaaa aagtcatata cttggtcatg atactgctga      960

ttgccccggc atacagcatc aggtgcatag gagtcagcaa tagggacttt gtggaaggta     1020

tgtcaggtgg gacttgggtt gatgttgtct tggaacatgg aggttgtgtc accgtaatgg     1080

cacaggacaa accgactgtc gacatagagc tggttacaac aacagtcagc aacatggcgg     1140

aggtaagatc ctactgctat gaggcatcaa tatcagacat ggcttctgac agccgctgcc     1200

caacacaagg tgaagcctac cttgacaagc aatcagacac tcaatatgtc tgcaaaagaa     1260

cgttagtgga cagaggctgg ggaaatggat gtggactttt tggcaaaggg agcctggtga     1320

catgcgctaa gtttgcatgc tccaagaaaa tgaccgggaa gagcatccag ccagagaatc     1380

tggagtaccg gataatgctg tcagttcatg gctcccagca cagtgggatg atcgttaatg     1440

acacaggaca tgaaactgat gagaatagag cgaaagttga gataacgccc aattcaccga     1500

gagccgaagc caccctgggg ggttttggaa gcctaggact tgattgtgaa ccgaggacag     1560

gccttgactt ttcagatttg tattacttga ctatgaataa caagcactgg ttggttcaca     1620

aggagtggtt ccacgacatt ccattacctt ggcacgctgg ggcagacacc ggaactccac     1680

actggaacaa caaagaagca ctggtagagt tcaaggacgc acatgccaaa aggcaaactg     1740

tcgtggttct agggagtcaa gaaggagcag ttcacacggc ccttgctgga gctctggagg     1800

ctgagatgga tggtgcaaag ggaaggctgt cctctggcca cttgaaatgt cgcctgaaaa     1860

tggataaact tagattgaag ggcgtgtcat actccttgtg tactgcagcg ttcacattca     1920

ccaagatccc ggctgaaaca ctgcacggga cagtcacagt ggaggtacag tacgcaggga     1980

cagatggacc ttgcaaggtt ccagctcaga tggcggtgga catgcaaact ctgaccccag     2040

ttgggaggtt gataaccgct aaccccgtaa tcactgaaag cactgagaac tctaagatga     2100

tgctggaact tgatccacca tttggggact cttacattgt cataggagtc ggggagaaga     2160

agatcaccca ccactggcac aggagtggca gcaccattgg aaaagcattt gaagccactg     2220

tgagaggtgc caagagaatg gcagtcttgg gagacacagc ctgggacttt ggatcagttg     2280

gaggcgctct caactcattg ggcaagggca tccatcaaat ttttggagca gctttcaaat     2340

cattgtttgg aggaatgtcc tggttctcac aaattctcat tggaacgttg ctgatgtggt     2400

tgggtctgaa cacaaagaat ggatctattt cccttatgtg cttggcctta gggggagtgt     2460

tgatcttctt atccacagcc gtctctgctg atgtggggtg ctcggtggac ttctcaaaga     2520

aggagacgag atgcggtaca ggggtgttcg tctataacga cgttgaagcc tggagggaca     2580

ggtacaagta ccatcctgac tccccccgta gattggcagc agcagtcaag caagcctggg     2640

aagatggtat ctgcgggatc tcctctgttt caagaatgga aaacatcatg tggagatcag     2700

tagaagggga gctcaacgca atcctggaag agaatggagt tcaactgacg gtcgttgtgg     2760

gatctgtaaa aaaccccatg tggagaggtc cacagagatt gcccgtgcct gtgaacgagc     2820

tgccccacgg ctggaaggct tgggggaaat cgtatttcgt cagagcagca aagacaaata     2880

acagctttgt cgtggatggt gacacactga aggaatgccc actcaaacat agagcatgga     2940

acagctttct tgtggaggat catgggttcg gggtatttca cactagtgtc tggctcaagg     3000

ttagagaaga ttattcatta gagtgtgatc cagccgttat tggaacagct gttaagggaa     3060

aggaggctgt acacagtgat ctaggctact ggattgagag tgagaagaat gacacatgga     3120

ggctgaagag ggcccatctg atcgagatga aaacatgtga atggccaaag tcccacacat     3180

tgtggacaga tggaatagaa gagagtgatc tgatcatacc caagtcttta gctgggccac     3240

tcagccatca caataccaga gagggctaca ggacccaaat gaaagggcca tggcacagtg     3300

aagagcttga aattcggttt gaggaatgcc caggcactaa ggtccacgtg gaggaaacat     3360

gtggaacaag aggaccatct ctgagatcaa ccactgcaag cggaagggtg atcgaggaat     3420

ggtgctgcag ggagtgcaca atgcccccac tgtcgttccg ggctaaagat ggctgttggt     3480

atggaatgga gataaggccc aggaaagaac cagaaagcaa cttagtaagg tcaatggtga     3540

ctgcaggatc aactgatcac atggaccact tctcccttgg agtgcttgtg atcctgctca     3600

tggtgcagga agggctgaag aagagaatga ccacaaagat catcataagc acatcaatgg     3660

cagtgctggt agctatgatc ctgggaggat tttcaatgag tgacctggct aagcttgcaa     3720

ttttgatggg tgccaccttc gcggaaatga acactggagg agatgtagct catctggcgc     3780

tgatagcggc attcaaagtc agaccagcgt tgctggtatc tttcatcttc agagctaatt     3840

ggacaccccg tgaaagcatg ctgctggcct tggcctcgtg tcttttgcaa actgcgatct     3900

ccgccttgga aggcgacctg atggttctca tcaatggttt tgctttggcc tggttggcaa     3960

tacgagcgat ggttgttcca cgcactgata acatcacctt ggcaatcctg gctgctctga     4020

caccactggc ccggggcaca ctgcttgtgg cgtggagagc aggccttgct acttgcgggg     4080

ggtttatgct cctctctctg aagggaaaag gcagtgtgaa gaagaactta ccatttgtca     4140

tggccctggg actaaccgct gtgaggctgg tcgaccccat caacgtggtg ggactgctgt     4200

tgctcacaag gagtgggaag cggagctggc cccctagcga agtactcaca gctgttggcc     4260

tgatatgcgc attggctgga gggttcgcca aggcagatat agagatggct gggcccatgg     4320

ccgcggtcgg tctgctaatt gtcagttacg tggtctcagg aaagagtgtg gacatgtaca     4380

ttgaaagagc aggtgacatc acatgggaaa aagatgcgga agtcactgga aacagtcccc     4440

ggctcgatgt ggcgctagat gagagtggtg atttctccct ggtggaggat gacggtcccc     4500

ccatgagaga gatcatactc aaggtggtcc tgatgaccat ctgtggcatg aacccaatag     4560

ccataccctt tgcagctgga gcgtggtacg tatacgtgaa gactggaaaa aggagtggtg     4620

ctctatggga tgtgcctgct cccaaggaag taaaaaaggg ggagaccaca gatggagtgt     4680

acagagtaat gactcgtaga ctgctaggtt caacacaagt tggagtggga gttatgcaag     4740

agggggtctt tcacactatg tggcacgtca caaaaggatc cgcgctgaga agcggtgaag     4800

ggagacttga tccatactgg ggagatgtca agcaggatct ggtgtcatac tgtggtccat     4860

ggaagctaga tgccgcctgg gatgggcaca gcgaggtgca gctcttggcc gtgccccccg     4920

gagagagagc gaggaacatc cagactctgc ccggaatatt taagacaaag gatggggaca     4980

ttggagcggt tgcgctggat tacccagcag gaacttcagg atctccaatc ctagacaagt     5040

gtgggagagt gataggactt tatggcaatg gggtcgtgat caaaaacggg agttatgtta     5100

gtgccatcac ccaagggagg agggaggaag agactcctgt tgagtgcttc gagccctcga     5160

tgctgaagaa gaagcagcta actgtcttag acttgcatcc tggagctggg aaaaccagga     5220

gagttcttcc tgaaatagtc cgtgaagcca taaaaacaag actccgtact gtgatcttag     5280

ctccaaccag ggttgtcgct gctgaaatgg aggaggccct tagagggctt ccagtgcgtt     5340

atatgacaac agcagtcaat gtcacccact ctggaacaga aatcgtcgac ttaatgtgcc     5400

atgccacctt cacttcacgt ctactacagc caatcagagt ccccaactat aatctgtata     5460

ttatggatga ggcccacttc acagatccct caagtatagc agcaagagga tacatttcaa     5520

caagggttga gatgggcgag gcggctgcca tcttcatgac cgccacgcca ccaggaaccc     5580

gtgacgcatt tccggactcc aactcaccaa ttatggacac cgaagtggaa gtcccagaga     5640

gagcctggag ctcaggcttt gattgggtga cggatcattc tggaaaaaca gtttggtttg     5700

ttccaagcgt gaggaacggc aatgagatcg cagcttgtct gacaaaggct ggaaaacggg     5760

tcatacagct cagcagaaag acttttgaga cagagttcca gaaaacaaaa catcaagagt     5820

gggactttgt cgtgacaact gacatttcag agatgggcgc caactttaaa gctgaccgtg     5880

tcatagattc caggagatgc ctaaagccgg tcatacttga tggcgagaga gtcattctgg     5940

ctggacccat gcctgtcaca catgccagcg ctgcccagag gagggggcgc ataggcagga     6000

atcccaacaa acctggagat gagtatctgt atggaggtgg gtgcgcagag actgacgaag     6060

accatgcaca ctggcttgaa gcaagaatgc tccttgacaa tatttacctc caagatggcc     6120

tcatagcctc gctctatcga cctgaggccg acaaagtagc agccattgag ggagagttca     6180

agcttaggac ggagcaaagg aagacctttg tggaactcat gaaaagagga gatcttcctg     6240

tttggctggc ctatcaggtt gcatctgccg gaataaccta cacagataga agatggtgct     6300

ttgatggcac gaccaacaac accataatgg aagacagtgt gccggcagag gtgtggacca     6360

gacacggaga gaaaagagtg ctcaaaccga ggtggatgga cgccagagtt tgttcagatc     6420

atgcggccct gaagtcattc aaggagtttg ccgctgggaa aagaggagcg gcttttggag     6480

tgatggaagc cctgggaaca ctgccaggac acatgacaga gagattccag gaagccattg     6540

acaacctcgc tgtgctcatg cgggcagaga ctggaagcag gccttacaaa gccgcggcgg     6600

cccaattgcc ggagacccta gagaccataa tgcttttggg gttgctggga acagtctcgc     6660

tgggaatctt cttcgtcttg atgaggaaca agggcatagg gaagatgggc tttggaatgg     6720

tgactcttgg ggccagcgca tggctcatgt ggctctcgga aattgagcca gccagaattg     6780

catgtgtcct cattgttgtg ttcctattgc tggtggtgct catacctgag ccagaaaagc     6840

aaagatctcc ccaggacaac caaatggcaa tcatcatcat ggtagcagta ggtcttctgg     6900

gcttgattac cgccaatgaa ctcggatggt tggagagaac aaagagtgac ctaagccatc     6960

taatgggaag gagagaggag ggggcaacca taggattctc aatggacatt gacctgcggc     7020

cagcctcagc ttgggccatc tatgctgcct tgacaacttt cattacccca gccgtccaac     7080

atgcagtgac cacctcatac aacaactact ccttaatggc gatggccacg caagctggag     7140

tgttgtttgg catgggcaaa gggatgccat tctacgcatg ggactttgga gtcccgctgc     7200

taatgatagg ttgctactca caattaacac ccctgaccct aatagtggcc atcattttgc     7260

tcgtggcgca ctacatgtac ttgatcccag ggctgcaggc agcagctgcg cgtgctgccc     7320

agaagagaac ggcagctggc atcatgaaga accctgttgt ggatggaata gtggtgactg     7380

acattgacac aatgacaatt gacccccaag tggagaaaaa gatgggacag gtgctactca     7440

tagcagtagc cgtctccagc gccatactgt cgcggaccgc ctgggggtgg ggggaggctg     7500

gggctctgat cacagccgca acttccactt tgtgggaagg ctctccgaac aagtactgga     7560

actcctctac agccacttca ctgtgtaaca tttttagggg aagttacttg gctggagctt     7620

ctctaatcta cacagtaaca agaaacgctg gcttggtcaa gagacgtggg ggtggaacag     7680

gagagaccct gggagagaaa tggaaggccc gcttgaacca gatgtcggcc ctggagttct     7740

actcctacaa aaagtcaggc atcaccgagg tgtgcagaga agaggcccgc cgcgccctca     7800

aggacggtgt ggcaacggga ggccatgctg tgtcccgagg aagtgcaaag ctgagatggt     7860

tggtggagcg gggatacctg cagccctatg gaaaggtcat tgatcttgga tgtggcagag     7920

ggggctggag ttactacgtc gccaccatcc gcaaagttca agaagtgaaa ggatacacaa     7980

aaggaggccc tggtcatgaa gaacccgtgt tggtgcaaag ctatgggtgg aacatagtcc     8040

gtcttaagag tggggtggac gtctttcata tggcggctga gccgtgtgac acgttgctgt     8100

gtgacatagg tgagtcatca tctagtcctg aagtggaaga agcacggacg ctcagagtcc     8160

tctccatggt gggggattgg cttgaaaaaa gaccaggagc cttttgtata aaagtgttgt     8220

gcccatacac cagcactatg atggaaaccc tggagcgact gcagcgtagg tatgggggag     8280

gactggtcag agtgccactc tcccgcaact ctacacatga gatgtactgg gtctctggag     8340

cgaaaagcaa caccataaaa agtgtgtcca ccacgagcca gctcctcttg gggcgcatgg     8400

acgggcctag gaggccagtg aaatatgagg aggatgtgaa tctcggctct ggcacgcggg     8460

ctgtggtaag ctgcgctgaa gctcccaaca tgaagatcat tggtaaccgc attgaaagga     8520

tccgcagtga gcacgcggaa acgtggttct ttgacgagaa ccacccatat aggacatggg     8580

cttaccatgg aagctatgag gcccccacac aagggtcagc gtcctctcta ataaacgggg     8640

ttgtcaggct cctgtcaaaa ccctgggatg tggtgactgg agtcacagga atagccatga     8700

ccgacaccac accgtatggt cagcaaagag ttttcaagga aaaagtggac actagggtgc     8760

cagaccccca agaaggcact cgtcaggtta tgagcatggt ctcttcctgg ttgtggaaag     8820

agctaggcaa acacaaacgg ccacgagtct gcaccaaaga agagttcatc aacaaggttc     8880

gtagcaatgc agcattaggg gcaatatttg aagaggaaaa agagtggaag actgcagtgg     8940

aagctgtgaa cgatccaagg ttctgggctc tagtggacaa ggaaagagag caccacctga     9000

gaggagagtg ccagagctgt gtgtacaaca tgatgggaaa aagagaaaag aaacaagggg     9060

aatttggaaa ggccaagggc agccgcgcca tctggtatat gtggctaggg gctagatttc     9120

tagagttcga agcccttgga ttcttgaacg aggatcactg gatggggaga gagaactcag     9180

gaggtggtgt tgaagggctg ggattacaaa gactcggata tgtcctagaa gagatgagtc     9240

gtataccagg aggaaggatg tatgcagatg acactgctgg ctgggacacc cgcattagca     9300

ggtttgatct ggagaatgaa gctctaatca ccaaccaaat ggagaaaggg cacagggcct     9360

tggcattggc cataatcaag tacacatacc aaaacaaagt ggtaaaggtc cttagaccag     9420

ctgaaaaagg gaaaacagtt atggacatta tttcgagaca agaccaaagg gggagcggac     9480

aagttgtcac ttacgctctt aacacattta ccaacctagt ggtgcaactc attcggaata     9540

tggaggctga ggaagttcta gagatgcaag acttgtggct gctgcggagg tcagagaaag     9600

tgaccaactg gttgcagagc aacggatggg ataggctcaa acgaatggca gtcagtggag     9660

atgattgcgt tgtgaagcca attgatgata ggtttgcaca tgccctcagg ttcttgaatg     9720

atatgggaaa agttaggaag gacacacaag agtggaaacc ctcaactgga tgggacaact     9780

gggaagaagt tccgttttgc tcccaccact tcaacaagct ccatctcaag gacgggaggt     9840

ccattgtggt tccctgccgc caccaagatg aactgattgg ccgggcccgc gtctctccag     9900

gggcgggatg gagcatccgg gagactgctt gcctagcaaa atcatatgcg caaatgtggc     9960

agctccttta tttccacaga agggacctcc gactgatggc caatgccatt tgttcatctg    10020

tgccagttga ctgggttcca actgggagaa ctacctggtc aatccatgga aagggagaat    10080

ggatgaccac tgaagacatg cttgtggtgt ggaacagagt gtggattgag gagaacgacc    10140

acatggaaga caagacccca gttacgaaat ggacagacat tccctatttg ggaaaaaggg    10200

aagacttgtg gtgtggatct ctcatagggc acagaccgcg caccacctgg gctgagaaca    10260

ttaaaaacac agtcaacatg gtgcgcagga tcataggtga tgaagaaaag tacatggact    10320

acctatccac ccaagttcgc tacttgggtg aagaagggtc tacacctgga gtgctgtaag    10380

caccaatctt aatgttgtca ggcctgctag tcagccacag cttggggaaa gctgtgcagc    10440

ctgtgacccc cccaggagaa gctgggaaac caagcctata gtcaggccga gaacgccatg    10500

gcacggaaga agccatgctg cctgtgagcc cctcagagga cactgagtca aaaaacccca    10560

cgcgcttgga ggcgcaggat gggaaaagaa ggtggcgacc ttccccaccc ttcaatctgg    10620

ggcctgaact ggagatcagc tgtggatctc cagaagaggg actagtggtt agaggagacc    10680

ccccggaaaa cgcaaaacag catattgacg ctgggaaaga ccagagactc catgagtttc    10740

caccacgctg gccgccaggc acagatcgcc gaatagcggc ggccggtgtg gggaaatcca    10800

tgggtct                                                              10807


<210>  16
<211>  3423
<212>  PRT
<213>  Zika virus strain PRVABC59

<400>  16

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Thr 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Val Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Val Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  17
<211>  11029
<212>  DNA
<213>  West Nile virus

<400>  17
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc      120

ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt      180

ggactgaaga gggctatgtt gagcctgatc gacggcaagg ggccaatacg atttgtgttg      240

gctctcttgg cgttcttcag gttcacagca attgctccga cccgagcagt gctggatcga      300

tggagaggtg tgaacaaaca aacagcgatg aaacaccttc tgagttttaa gaaggaacta      360

gggaccttga ccagtgctat caatcggcgg agctcaaaac aaaagaaaag aggaggaaag      420

accggaattg cagtcatgat tggcctgatc gccagcgtag gagcagttac cctctctaac      480

ttccaaggga aggtgatgat gacggtaaat gctactgacg tcacagatgt catcacgatt      540

ccaacagctg ctggaaagaa cctatgcatt gtcagagcaa tggatgtggg atacatgtgc      600

gatgatacta tcacttatga atgcccagtg ctgtcggctg gtaatgatcc agaagacatc      660

gactgttggt gcacaaagtc agcagtctac gtcaggtatg gaagatgcac caagacacgc      720

cactcaagac gcagtcggag gtcactgaca gtgcagacac acggagaaag cactctagcg      780

aacaagaagg gggcttggat ggacagcacc aaggccacaa ggtatttggt aaaaacagaa      840

tcatggatct tgaggaaccc tggatatgcc ctggtggcag ccgtcattgg ttggatgctt      900

gggagcaaca ccatgcagag agttgtgttt gtcgtgctat tgcttttggt ggccccagct      960

tacagcttca actgccttgg aatgagcaac agagacttct tggaaggagt gtctggagca     1020

acatgggtgg atttggttct cgaaggcgac agctgcgtga ctatcatgtc taaggacaag     1080

cctaccatcg atgtgaagat gatgaatatg gaggcggcca acctggcaga ggtccgcagt     1140

tattgctatt tggctaccgt cagcgatctc tccaccaaag ctgcgtgccc gaccatggga     1200

gaagctcaca atgacaaacg tgctgaccca gcttttgtgt gcagacaagg agtggtggac     1260

aggggctggg gcaacggctg cggactattt ggcaaaggaa gcattgacac atgcgccaaa     1320

tttgcctgct ctaccaaggc aataggaaga accatcttga aagagaatat caagtacgaa     1380

gtggccattt ttgtccatgg accaactact gtggagtcgc acggaaacta ctccacacag     1440

gttggagcca ctcaggcagg gagattcagc atcactcctg cggcgccttc atacacacta     1500

aagcttggag aatatggaga ggtgacagtg gactgtgaac cacggtcagg gattgacacc     1560

aatgcatact acgtgatgac tgttggaaca aagacgttct tggtccatcg tgagtggttc     1620

atggacctca acctcccttg gagcagtgct ggaagtactg tgtggaggaa cagagagacg     1680

ttaatggagt ttgaggaacc acacgccacg aagcagtctg tgatagcatt gggctcacaa     1740

gagggagctc tgcatcaagc tttggctgga gccattcctg tggaattttc aagcaacact     1800

gtcaagttga cgtcgggtca tttgaagtgt agagtgaaga tggaaaaatt gcagttgaag     1860

ggaacaacct atggcgtctg ttcaaaggct ttcaagtttc ttgggactcc cgcagacaca     1920

ggtcacggca ctgtggtgtt ggaattgcag tacactggca cggatggacc ttgcaaagtt     1980

cctatctcgt cagtggcttc attgaacgac ctaacgccag tgggcagatt ggtcactgtc     2040

aacccttttg tttcagtggc cacggccaac gctaaggtcc tgattgaatt ggaaccaccc     2100

tttggagact catacatagt ggtgggcaga ggagaacaac agatcaatca ccattggcac     2160

aagtctggaa gcagcattgg caaagccttt acaaccaccc tcaaaggagc gcagagacta     2220

gccgctctag gagacacagc ttgggacttt ggatcagttg gaggggtgtt cacctcagtt     2280

gggaaggctg tccatcaagt gttcggagga gcattccgct cactgttcgg aggcatgtcc     2340

tggataacgc aaggattgct gggggctctc ctgttgtgga tgggcatcaa tgctcgtgat     2400

aggtccatag ctctcacgtt tctcgcagtt ggaggagttc tgctcttcct ctccgtgaac     2460

gtgcacgctg acactgggtg tgccatagac atcagccggc aagagctgag atgtggaagt     2520

ggagtgttca tacacaatga tgtggaggct tggatggacc ggtacaagta ttaccctgaa     2580

acgccacaag gcctagccaa gatcattcag aaagctcata aggaaggagt gtgcggtcta     2640

cgatcagttt ccagactgga gcatcaaatg tgggaagcag tgaaggacga gctgaacact     2700

cttttgaagg agaatggtgt ggaccttagt gtcgtggttg agaaacagga gggaatgtac     2760

aagtcagcac ctaaacgcct caccgccacc acggaaaaat tggaaattgg ctggaaggcc     2820

tggggaaaga gtattttatt tgcaccagaa ctcgccaaca acacctttgt ggttgatggt     2880

ccggagacca aggaatgtcc gactcagaat cgcgcttgga atagcttaga agtggaggat     2940

tttggatttg gtctcaccag cactcggatg ttcctgaagg tcagagagag caacacaact     3000

gaatgtgact cgaagatcat tggaacggct gtcaagaaca acttggcgat ccacagtgac     3060

ctgtcctatt ggattgaaag caggctcaat gatacgtgga agcttgaaag ggcagttctg     3120

ggtgaagtca aatcatgtac gtggcctgag acgcatacct tgtggggcga tggaatcctt     3180

gagagtgact tgataatacc agtcacactg gcgggaccac gaagcaatca caatcggaga     3240

cctgggtaca agacacaaaa ccagggccca tgggacgaag gccgggtaga gattgacttc     3300

gattactgcc caggaactac ggtcaccctg agtgagagct gcggacaccg tggacctgcc     3360

actcgcacca ccacagagag cggaaagttg ataacagatt ggtgctgcag gagctgcacc     3420

ttaccaccac tgcgctacca aactgacagc ggctgttggt atggtatgga gatcagacca     3480

cagagacatg atgaaaagac cctcgtgcag tcacaagtga atgcttataa tgctgatatg     3540

attgaccctt ttcagttggg ccttctggtc gtgttcttgg ccacccagga ggtccttcgc     3600

aagaggtgga cagccaagat cagcatgcca gctatactga ttgctctgct agtcctggtg     3660

tttgggggca ttacttacac tgatgtgtta cgctatgtca tcttggtggg ggcagctttc     3720

gcagaatcta attcgggagg agacgtggta cacttggcgc tcatggcgac cttcaagata     3780

caaccagtgt ttatggtggc atcgtttctc aaagcgagat ggaccaacca ggagaacatt     3840

ttgttgatgt tggcggctgt tttctttcaa atggcttatc acgatgcccg ccaaattctg     3900

ctctgggaga tccctgatgt gttgaattca ctggcggtag cttggatgat actgagagcc     3960

ataacattca caacgacatc aaacgtggtt gttccgctgc tagccctgct aacacccggg     4020

ctgagatgct tgaatctgga tgtgtacagg atactgctgt tgatggtcgg aataggcagc     4080

ttgatcaggg agaagaggag tgcagctgca aaaaagaaag gagcaagtct gctatgcttg     4140

gctctagcct caacaggact tttcaacccc atgatccttg ctgctggact gattgcatgt     4200

gatcccaacc gtaaacgcgg atggcccgca actgaagtga tgacagctgt cggcctaatg     4260

tttgccatcg tcggagggct ggcagagctt gacattgact ccatggccat tccaatgact     4320

atcgcggggc tcatgtttgc tgctttcgtg atttctggga aatcaacaga tatgtggatt     4380

gagagaacgg cggacatttc ctgggaaagt gatgcagaaa ttacaggctc gagcgaaaga     4440

gttgatgtgc ggcttgatga tgatggaaac ttccagctca tgaatgatcc aggagcacct     4500

tggaagatat ggatgctcag aatggtctgt ctcgcgatta gtgcgtacac cccctgggca     4560

atcttgccct cagtagttgg attttggata actctccaat acacaaagag aggaggcgtg     4620

ttgtgggaca ctccctcacc aaaggagtac aaaaaggggg acacgaccac cggcgtctac     4680

aggatcatga ctcgtgggct gctcggcagt tatcaagcag gagcgggcgt gatggttgaa     4740

ggtgttttcc acaccctttg gcatacaaca aaaggagccg ctttgatgag cggagagggc     4800

cgcctggacc catactgggg cagtgtcaag gaggatcgac tttgttacgg aggaccctgg     4860

aaattgcagc acaagtggaa cgggcaggat gaggtgcaga tgattgtggt ggaacctggc     4920

aagaacgtta agaacgtcca gacgaaacca ggggtgttca aaacacctga aggagaaatc     4980

ggggccgtga ctttggactt ccccactgga acatcaggct caccaatagt ggacaaaaac     5040

ggtgatgtga ttgggcttta tggcaatgga gtcataatgc ccaacggctc atacataagc     5100

gcgatagtgc agggtgaaag gatggatgag ccaatcccag ccggattcga acctgagatg     5160

ctgaggaaaa aacagatcac tgtactggat ctccatcccg gcgccggtaa aacaaggagg     5220

attctgccac agatcatcaa agaggccata aacagaagac tgagaacagc cgtgctagca     5280

ccaaccaggg ttgtggctgc tgagatggct gaagcactga gaggactgcc catccggtac     5340

cagacatccg cagtgcccag agaacataat ggaaatgaga ttgttgatgt catgtgtcat     5400

gctaccctca cccacaggct gatgtctcct cacagggtgc cgaactacaa cctgttcgtg     5460

atggatgagg ctcatttcac cgacccagct agcattgcag caagaggtta catttccaca     5520

aaggtcgagc taggggaggc ggcggcaata ttcatgacag ccaccccacc aggcacttca     5580

gatccattcc cagagtccaa ttcaccaatt tccgacttac agactgagat cccggatcga     5640

gcttggaact ctggatacga atggatcaca gaatacaccg ggaagacggt ttggtttgtg     5700

cctagtgtca agatggggaa tgagattgcc ctttgcctac aacgtgctgg aaagaaagta     5760

gtccaattga acagaaagtc gtacgagacg gagtacccaa aatgtaagaa cgatgattgg     5820

gactttgtta tcacaacaga catatctgaa atgggggcta acttcaaggc gagcagggtg     5880

attgacagcc ggaagagtgt gaaaccaacc atcataacag aaggagaagg gagagtgatc     5940

ctgggagaac catctgcagt gacagcagct agtgccgccc agagacgtgg acgtatcggt     6000

agaaatccgt cgcaagttgg tgatgagtac tgttatgggg ggcacacgaa tgaagacgac     6060

tcgaacttcg cccattggac tgaggcacga atcatgctgg acaacatcaa catgccaaac     6120

ggactgatcg ctcaattcta ccaaccagag cgtgagaagg tatataccat ggatggggaa     6180

taccggctca gaggagaaga gagaaaaaac tttctggaac tgttgaggac tgcagatctg     6240

ccagtttggc tggcttacaa ggttgcagcg gctggagtgt cataccacga ccggaggtgg     6300

tgctttgatg gtcctaggac aaacacaatt ttagaagaca acaacgaagt ggaagtcatc     6360

acgaagcttg gtgaaaggaa gattctgagg ccgcgctgga ttgacgccag ggtgtactcg     6420

gatcaccagg cactaaaggc gttcaaggac ttcgcctcgg gaaaacgttc tcagataggg     6480

ctcattgagg ttctgggaaa gatgcctgag cacttcatgg ggaagacatg ggaagcactt     6540

gacaccatgt acgttgtggc cactgcagag aaaggaggaa gagctcacag aatggccctg     6600

gaggaactgc cagatgctct tcagacaatt gccttgattg ccttattgag tgtgatgacc     6660

atgggagtat tcttcctcct catgcagcgg aagggcattg gaaagatagg tttgggaggc     6720

gctgtcttgg gagtcgcgac ctttttctgt tggatggctg aagttccagg aacgaagatc     6780

gccggaatgt tgctgctctc ccttctcttg atgattgtgc taattcctga gccagagaag     6840

caacgttcgc agacagacaa ccagctagcc gtgttcctga tttgtgtcat gacccttgtg     6900

agcgcagtgg cagccaacga gatgggttgg ctagataaga ccaagagtga cataagcagt     6960

ttgtttgggc aaagaattga ggtcaaggag aatttcagca tgggagagtt tcttttggac     7020

ttgaggccgg caacagcctg gtcactgtac gctgtgacaa cagcggtcct cactccactg     7080

ctaaagcatt tgatcacgtc agattacatc aacacctcat tgacctcaat aaacgttcag     7140

gcaagtgcac tattcacact cgcgcgaggc ttccccttcg tcgatgttgg agtgtcggct     7200

ctcctgctag cagccggatg ctggggacaa gtcaccctca ccgttacggt aacagcggca     7260

acactccttt tttgccacta tgcctacatg gttcccggtt ggcaagctga ggcaatgcgc     7320

tcagcccagc ggcggacagc ggccggaatc atgaagaacg ctgtagtgga tggcatcgtg     7380

gccacggacg tcccagaatt agagcgcacc acacccatca tgcagaagaa agttggacag     7440

atcatgctga tcttggtgtc tctagctgca gtagtagtga acccgtctgt gaagacagta     7500

cgagaagccg gaattttgat cacggccgca gcggtgacgc tttgggagaa tggagcaagc     7560

tctgtttgga acgcaacaac tgccatcgga ctctgccaca tcatgcgtgg gggttggttg     7620

tcatgtctat ccataacatg gacactcata aagaacatgg aaaaaccagg actaaaaaga     7680

ggtggggcaa aaggacgcac cttgggagag gtttggaaag aaagactcaa ccagatgaca     7740

aaagaagagt tcactaggta ccgcaaagag gccatcatcg aagtcgatcg ctcagcggca     7800

aaacacgcca ggaaagaagg caatgtcact ggagggcatc cagtctctag gggcacagca     7860

aaactgagat ggctggtcga acggaggttt ctcgaaccgg tcggaaaagt gattgacctt     7920

ggatgtggaa gaggcggttg gtgttactat atggcaaccc aaaaaagagt ccaagaagtc     7980

agagggtaca caaagggcgg tcccggacat gaagagcccc aactagtgca aagttatgga     8040

tggaacattg tcaccatgaa gagtggagtg gatgtgttct acagaccttc tgagtgttgt     8100

gacaccctcc tttgtgacat cggagagtcc tcgtcaagtg ctgaggttga agagcatagg     8160

acgattcggg tccttgaaat ggttgaggac tggctgcacc gagggccaag ggaattttgc     8220

gtgaaggtgc tctgccccta catgccgaaa gtcatagaga agatggagct gctccaacgc     8280

cggtatgggg ggggactggt cagaaaccca ctctcacgga attccacgca cgagatgtat     8340

tgggtgagtc gagcttcagg caatgtggta cattcagtga atatgaccag ccaggtgctc     8400

ctaggaagaa tggaaaaaag gacctggaag ggaccccaat acgaggaaga tgtaaacttg     8460

ggaagtggaa ccagggcggt gggaaaaccc ctgctcaact cagacaccag taaaatcaag     8520

aacaggattg aacgactcag gcgtgagtac agttcgacgt ggcaccacga tgagaaccac     8580

ccatatagaa cctggaacta tcacggcagt tatgatgtga agcccacagg ctccgccagt     8640

tcgctggtca atggagtggt caggctcctc tcaaaaccat gggacaccat cacgaatgtt     8700

accaccatgg ccatgactga cactactccc ttcgggcagc agcgagtgtt caaagagaag     8760

gtggacacga aagctcctga accgccagaa ggagtgaagt acgtgctcaa tgagaccacc     8820

aactggttgt gggcgttttt ggccagagaa aaacgtccca gaatgtgctc tcgagaggaa     8880

ttcataagaa aggtcaacag caatgcagct ttgggtgcca tgtttgaaga gcagaatcaa     8940

tggaggagcg ccagagaagc agttgaagat ccaaaatttt gggagatggt ggatgaggag     9000

cgcgaggcac atctgcgggg ggaatgtcac acttgcattt acaacatgat gggaaagaga     9060

gagaaaaaac ccggagagtt cggaaaggcc aagggaagca gagccatttg gttcatgtgg     9120

ctcggagctc gctttctgga gttcgaggct ctgggttttc tcaatgaaga ccactggctt     9180

ggaagaaaga actcaggagg aggtgtcgag ggcttgggcc tccaaaaact gggttacatc     9240

ctgcgtgaag ttggcacccg gcctgggggc aagatctatg ctgatgacac agctggctgg     9300

gacacccgca tcacgagagc tgacttggaa aatgaagcta aggtgcttga gctgcttgat     9360

ggggaacatc ggcgtcttgc cagggccatc attgagctca cctatcgtca caaagttgtg     9420

aaagtgatgc gcccggctgc tgatggaaga accgtcatgg atgttatctc cagagaagat     9480

cagaggggga gtggacaagt tgtcacctac gccctaaaca ctttcaccaa cctggccgtc     9540

cagctggtga ggatgatgga aggggaagga gtgattggcc cagatgatgt ggagaaactc     9600

acaaaaggga aaggacccaa agtcaggacc tggctgtttg agaatgggga agaaagactc     9660

agccgcatgg ctgtcagtgg agatgactgt gtggtaaagc ccctggacga tcgctttgcc     9720

acctcgctcc acttcctcaa tgctatgtca aaggttcgca aagacatcca agagtggaaa     9780

ccgtcaactg gatggtatga ttggcagcag gttccatttt gctcaaacca tttcactgaa     9840

ttgatcatga aagatggaag aacactggtg gttccatgcc gaggacagga tgaattggta     9900

ggcagagctc gcatatctcc aggggccgga tggaacgtcc gcgacactgc ttgtctggct     9960

aagtcttatg cccagatgtg gctgcttctg tacttccaca gaagagacct gcggctcatg    10020

gccaacgcca tttgctccgc tgtccctgtg aattgggtcc ctaccggaag aaccacgtgg    10080

tccatccatg caggaggaga gtggatgaca acagaggaca tgttggaggt ctggaaccgt    10140

gtttggatag aggagaatga atggatggaa gacaaaaccc cagtggagaa atggagtgac    10200

gtcccatatt caggaaaacg agaggacatc tggtgtggca gcctgattgg cacaagagcc    10260

cgagccacgt gggcagaaaa catccaggtg gctatcaacc aagtcagagc aatcatcgga    10320

gatgagaagt atgtggatta catgagttca ctaaagagat atgaagacac aactttggtt    10380

gaggacacag tactgtagat atttaatcaa ttgtaaatag acaatataag tatgcataaa    10440

agtgtagttt tatagtagta tttagtggtg ttagtgtaaa tagttaagaa aattttgagg    10500

agaaagtcag gccgggaagt tcccgccacc ggaagttgag tagacggtgc tgcctgcgac    10560

tcaaccccag gaggactggg tgaacaaagc cgcgaagtga tccatgtaag ccctcagaac    10620

cgtctcggaa ggaggacccc acatgttgta acttcaaagc ccaatgtcag accacgctac    10680

ggcgtgctac tctgcggaga gtgcagtctg cgatagtgcc ccaggaggac tgggttaaca    10740

aaggcaaacc aacgccccac gcggccctag ccccggtaat ggtgttaacc agggcgaaag    10800

gactagaggt tagaggagac cccgcggttt aaagtgcacg gcccagcctg actgaagctg    10860

taggtcaggg gaaggactag aggttagtgg agaccccgtg ccacaaaaca ccacaacaaa    10920

acagcatatt gacacctggg atagactagg agatcttctg ctctgcacaa ccagccacac    10980

ggcacagtgc gccgacaatg gtggctggtg gtgcgagaac acaggatct                11029


<210>  18
<211>  3433
<212>  PRT
<213>  West Nile virus

<400>  18

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
        35                  40                  45              


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
    50                  55                  60                  


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
65                  70                  75                  80  


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
                85                  90                  95      


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala 
            100                 105                 110         


Val Met Ile Gly Leu Ile Ala Ser Val Gly Ala Val Thr Leu Ser Asn 
        115                 120                 125             


Phe Gln Gly Lys Val Met Met Thr Val Asn Ala Thr Asp Val Thr Asp 
    130                 135                 140                 


Val Ile Thr Ile Pro Thr Ala Ala Gly Lys Asn Leu Cys Ile Val Arg 
145                 150                 155                 160 


Ala Met Asp Val Gly Tyr Met Cys Asp Asp Thr Ile Thr Tyr Glu Cys 
                165                 170                 175     


Pro Val Leu Ser Ala Gly Asn Asp Pro Glu Asp Ile Asp Cys Trp Cys 
            180                 185                 190         


Thr Lys Ser Ala Val Tyr Val Arg Tyr Gly Arg Cys Thr Lys Thr Arg 
        195                 200                 205             


His Ser Arg Arg Ser Arg Arg Ser Leu Thr Val Gln Thr His Gly Glu 
    210                 215                 220                 


Ser Thr Leu Ala Asn Lys Lys Gly Ala Trp Met Asp Ser Thr Lys Ala 
225                 230                 235                 240 


Thr Arg Tyr Leu Val Lys Thr Glu Ser Trp Ile Leu Arg Asn Pro Gly 
                245                 250                 255     


Tyr Ala Leu Val Ala Ala Val Ile Gly Trp Met Leu Gly Ser Asn Thr 
            260                 265                 270         


Met Gln Arg Val Val Phe Val Val Leu Leu Leu Leu Val Ala Pro Ala 
        275                 280                 285             


Tyr Ser Phe Asn Cys Leu Gly Met Ser Asn Arg Asp Phe Leu Glu Gly 
    290                 295                 300                 


Val Ser Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys 
305                 310                 315                 320 


Val Thr Ile Met Ser Lys Asp Lys Pro Thr Ile Asp Val Lys Met Met 
                325                 330                 335     


Asn Met Glu Ala Ala Asn Leu Ala Glu Val Arg Ser Tyr Cys Tyr Leu 
            340                 345                 350         


Ala Thr Val Ser Asp Leu Ser Thr Lys Ala Ala Cys Pro Thr Met Gly 
        355                 360                 365             


Glu Ala His Asn Asp Lys Arg Ala Asp Pro Ala Phe Val Cys Arg Gln 
    370                 375                 380                 


Gly Val Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Ile Asp Thr Cys Ala Lys Phe Ala Cys Ser Thr Lys Ala Ile 
                405                 410                 415     


Gly Arg Thr Ile Leu Lys Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe 
            420                 425                 430         


Val His Gly Pro Thr Thr Val Glu Ser His Gly Asn Tyr Ser Thr Gln 
        435                 440                 445             


Val Gly Ala Thr Gln Ala Gly Arg Phe Ser Ile Thr Pro Ala Ala Pro 
    450                 455                 460                 


Ser Tyr Thr Leu Lys Leu Gly Glu Tyr Gly Glu Val Thr Val Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Ser Gly Ile Asp Thr Asn Ala Tyr Tyr Val Met Thr Val 
                485                 490                 495     


Gly Thr Lys Thr Phe Leu Val His Arg Glu Trp Phe Met Asp Leu Asn 
            500                 505                 510         


Leu Pro Trp Ser Ser Ala Gly Ser Thr Val Trp Arg Asn Arg Glu Thr 
        515                 520                 525             


Leu Met Glu Phe Glu Glu Pro His Ala Thr Lys Gln Ser Val Ile Ala 
    530                 535                 540                 


Leu Gly Ser Gln Glu Gly Ala Leu His Gln Ala Leu Ala Gly Ala Ile 
545                 550                 555                 560 


Pro Val Glu Phe Ser Ser Asn Thr Val Lys Leu Thr Ser Gly His Leu 
                565                 570                 575     


Lys Cys Arg Val Lys Met Glu Lys Leu Gln Leu Lys Gly Thr Thr Tyr 
            580                 585                 590         


Gly Val Cys Ser Lys Ala Phe Lys Phe Leu Gly Thr Pro Ala Asp Thr 
        595                 600                 605             


Gly His Gly Thr Val Val Leu Glu Leu Gln Tyr Thr Gly Thr Asp Gly 
    610                 615                 620                 


Pro Cys Lys Val Pro Ile Ser Ser Val Ala Ser Leu Asn Asp Leu Thr 
625                 630                 635                 640 


Pro Val Gly Arg Leu Val Thr Val Asn Pro Phe Val Ser Val Ala Thr 
                645                 650                 655     


Ala Asn Ala Lys Val Leu Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser 
            660                 665                 670         


Tyr Ile Val Val Gly Arg Gly Glu Gln Gln Ile Asn His His Trp His 
        675                 680                 685             


Lys Ser Gly Ser Ser Ile Gly Lys Ala Phe Thr Thr Thr Leu Lys Gly 
    690                 695                 700                 


Ala Gln Arg Leu Ala Ala Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser 
705                 710                 715                 720 


Val Gly Gly Val Phe Thr Ser Val Gly Lys Ala Val His Gln Val Phe 
                725                 730                 735     


Gly Gly Ala Phe Arg Ser Leu Phe Gly Gly Met Ser Trp Ile Thr Gln 
            740                 745                 750         


Gly Leu Leu Gly Ala Leu Leu Leu Trp Met Gly Ile Asn Ala Arg Asp 
        755                 760                 765             


Arg Ser Ile Ala Leu Thr Phe Leu Ala Val Gly Gly Val Leu Leu Phe 
    770                 775                 780                 


Leu Ser Val Asn Val His Ala Asp Thr Gly Cys Ala Ile Asp Ile Ser 
785                 790                 795                 800 


Arg Gln Glu Leu Arg Cys Gly Ser Gly Val Phe Ile His Asn Asp Val 
                805                 810                 815     


Glu Ala Trp Met Asp Arg Tyr Lys Tyr Tyr Pro Glu Thr Pro Gln Gly 
            820                 825                 830         


Leu Ala Lys Ile Ile Gln Lys Ala His Lys Glu Gly Val Cys Gly Leu 
        835                 840                 845             


Arg Ser Val Ser Arg Leu Glu His Gln Met Trp Glu Ala Val Lys Asp 
    850                 855                 860                 


Glu Leu Asn Thr Leu Leu Lys Glu Asn Gly Val Asp Leu Ser Val Val 
865                 870                 875                 880 


Val Glu Lys Gln Glu Gly Met Tyr Lys Ser Ala Pro Lys Arg Leu Thr 
                885                 890                 895     


Ala Thr Thr Glu Lys Leu Glu Ile Gly Trp Lys Ala Trp Gly Lys Ser 
            900                 905                 910         


Ile Leu Phe Ala Pro Glu Leu Ala Asn Asn Thr Phe Val Val Asp Gly 
        915                 920                 925             


Pro Glu Thr Lys Glu Cys Pro Thr Gln Asn Arg Ala Trp Asn Ser Leu 
    930                 935                 940                 


Glu Val Glu Asp Phe Gly Phe Gly Leu Thr Ser Thr Arg Met Phe Leu 
945                 950                 955                 960 


Lys Val Arg Glu Ser Asn Thr Thr Glu Cys Asp Ser Lys Ile Ile Gly 
                965                 970                 975     


Thr Ala Val Lys Asn Asn Leu Ala Ile His Ser Asp Leu Ser Tyr Trp 
            980                 985                 990         


Ile Glu Ser Arg Leu Asn Asp Thr  Trp Lys Leu Glu Arg  Ala Val Leu 
        995                 1000                 1005             


Gly Glu  Val Lys Ser Cys Thr  Trp Pro Glu Thr His  Thr Leu Trp 
    1010                 1015                 1020             


Gly Asp  Gly Ile Leu Glu Ser  Asp Leu Ile Ile Pro  Val Thr Leu 
    1025                 1030                 1035             


Ala Gly  Pro Arg Ser Asn His  Asn Arg Arg Pro Gly  Tyr Lys Thr 
    1040                 1045                 1050             


Gln Asn  Gln Gly Pro Trp Asp  Glu Gly Arg Val Glu  Ile Asp Phe 
    1055                 1060                 1065             


Asp Tyr  Cys Pro Gly Thr Thr  Val Thr Leu Ser Glu  Ser Cys Gly 
    1070                 1075                 1080             


His Arg  Gly Pro Ala Thr Arg  Thr Thr Thr Glu Ser  Gly Lys Leu 
    1085                 1090                 1095             


Ile Thr  Asp Trp Cys Cys Arg  Ser Cys Thr Leu Pro  Pro Leu Arg 
    1100                 1105                 1110             


Tyr Gln  Thr Asp Ser Gly Cys  Trp Tyr Gly Met Glu  Ile Arg Pro 
    1115                 1120                 1125             


Gln Arg  His Asp Glu Lys Thr  Leu Val Gln Ser Gln  Val Asn Ala 
    1130                 1135                 1140             


Tyr Asn  Ala Asp Met Ile Asp  Pro Phe Gln Leu Gly  Leu Leu Val 
    1145                 1150                 1155             


Val Phe  Leu Ala Thr Gln Glu  Val Leu Arg Lys Arg  Trp Thr Ala 
    1160                 1165                 1170             


Lys Ile  Ser Met Pro Ala Ile  Leu Ile Ala Leu Leu  Val Leu Val 
    1175                 1180                 1185             


Phe Gly  Gly Ile Thr Tyr Thr  Asp Val Leu Arg Tyr  Val Ile Leu 
    1190                 1195                 1200             


Val Gly  Ala Ala Phe Ala Glu  Ser Asn Ser Gly Gly  Asp Val Val 
    1205                 1210                 1215             


His Leu  Ala Leu Met Ala Thr  Phe Lys Ile Gln Pro  Val Phe Met 
    1220                 1225                 1230             


Val Ala  Ser Phe Leu Lys Ala  Arg Trp Thr Asn Gln  Glu Asn Ile 
    1235                 1240                 1245             


Leu Leu  Met Leu Ala Ala Val  Phe Phe Gln Met Ala  Tyr His Asp 
    1250                 1255                 1260             


Ala Arg  Gln Ile Leu Leu Trp  Glu Ile Pro Asp Val  Leu Asn Ser 
    1265                 1270                 1275             


Leu Ala  Val Ala Trp Met Ile  Leu Arg Ala Ile Thr  Phe Thr Thr 
    1280                 1285                 1290             


Thr Ser  Asn Val Val Val Pro  Leu Leu Ala Leu Leu  Thr Pro Gly 
    1295                 1300                 1305             


Leu Arg  Cys Leu Asn Leu Asp  Val Tyr Arg Ile Leu  Leu Leu Met 
    1310                 1315                 1320             


Val Gly  Ile Gly Ser Leu Ile  Arg Glu Lys Arg Ser  Ala Ala Ala 
    1325                 1330                 1335             


Lys Lys  Lys Gly Ala Ser Leu  Leu Cys Leu Ala Leu  Ala Ser Thr 
    1340                 1345                 1350             


Gly Leu  Phe Asn Pro Met Ile  Leu Ala Ala Gly Leu  Ile Ala Cys 
    1355                 1360                 1365             


Asp Pro  Asn Arg Lys Arg Gly  Trp Pro Ala Thr Glu  Val Met Thr 
    1370                 1375                 1380             


Ala Val  Gly Leu Met Phe Ala  Ile Val Gly Gly Leu  Ala Glu Leu 
    1385                 1390                 1395             


Asp Ile  Asp Ser Met Ala Ile  Pro Met Thr Ile Ala  Gly Leu Met 
    1400                 1405                 1410             


Phe Ala  Ala Phe Val Ile Ser  Gly Lys Ser Thr Asp  Met Trp Ile 
    1415                 1420                 1425             


Glu Arg  Thr Ala Asp Ile Ser  Trp Glu Ser Asp Ala  Glu Ile Thr 
    1430                 1435                 1440             


Gly Ser  Ser Glu Arg Val Asp  Val Arg Leu Asp Asp  Asp Gly Asn 
    1445                 1450                 1455             


Phe Gln  Leu Met Asn Asp Pro  Gly Ala Pro Trp Lys  Ile Trp Met 
    1460                 1465                 1470             


Leu Arg  Met Val Cys Leu Ala  Ile Ser Ala Tyr Thr  Pro Trp Ala 
    1475                 1480                 1485             


Ile Leu  Pro Ser Val Val Gly  Phe Trp Ile Thr Leu  Gln Tyr Thr 
    1490                 1495                 1500             


Lys Arg  Gly Gly Val Leu Trp  Asp Thr Pro Ser Pro  Lys Glu Tyr 
    1505                 1510                 1515             


Lys Lys  Gly Asp Thr Thr Thr  Gly Val Tyr Arg Ile  Met Thr Arg 
    1520                 1525                 1530             


Gly Leu  Leu Gly Ser Tyr Gln  Ala Gly Ala Gly Val  Met Val Glu 
    1535                 1540                 1545             


Gly Val  Phe His Thr Leu Trp  His Thr Thr Lys Gly  Ala Ala Leu 
    1550                 1555                 1560             


Met Ser  Gly Glu Gly Arg Leu  Asp Pro Tyr Trp Gly  Ser Val Lys 
    1565                 1570                 1575             


Glu Asp  Arg Leu Cys Tyr Gly  Gly Pro Trp Lys Leu  Gln His Lys 
    1580                 1585                 1590             


Trp Asn  Gly Gln Asp Glu Val  Gln Met Ile Val Val  Glu Pro Gly 
    1595                 1600                 1605             


Lys Asn  Val Lys Asn Val Gln  Thr Lys Pro Gly Val  Phe Lys Thr 
    1610                 1615                 1620             


Pro Glu  Gly Glu Ile Gly Ala  Val Thr Leu Asp Phe  Pro Thr Gly 
    1625                 1630                 1635             


Thr Ser  Gly Ser Pro Ile Val  Asp Lys Asn Gly Asp  Val Ile Gly 
    1640                 1645                 1650             


Leu Tyr  Gly Asn Gly Val Ile  Met Pro Asn Gly Ser  Tyr Ile Ser 
    1655                 1660                 1665             


Ala Ile  Val Gln Gly Glu Arg  Met Asp Glu Pro Ile  Pro Ala Gly 
    1670                 1675                 1680             


Phe Glu  Pro Glu Met Leu Arg  Lys Lys Gln Ile Thr  Val Leu Asp 
    1685                 1690                 1695             


Leu His  Pro Gly Ala Gly Lys  Thr Arg Arg Ile Leu  Pro Gln Ile 
    1700                 1705                 1710             


Ile Lys  Glu Ala Ile Asn Arg  Arg Leu Arg Thr Ala  Val Leu Ala 
    1715                 1720                 1725             


Pro Thr  Arg Val Val Ala Ala  Glu Met Ala Glu Ala  Leu Arg Gly 
    1730                 1735                 1740             


Leu Pro  Ile Arg Tyr Gln Thr  Ser Ala Val Pro Arg  Glu His Asn 
    1745                 1750                 1755             


Gly Asn  Glu Ile Val Asp Val  Met Cys His Ala Thr  Leu Thr His 
    1760                 1765                 1770             


Arg Leu  Met Ser Pro His Arg  Val Pro Asn Tyr Asn  Leu Phe Val 
    1775                 1780                 1785             


Met Asp  Glu Ala His Phe Thr  Asp Pro Ala Ser Ile  Ala Ala Arg 
    1790                 1795                 1800             


Gly Tyr  Ile Ser Thr Lys Val  Glu Leu Gly Glu Ala  Ala Ala Ile 
    1805                 1810                 1815             


Phe Met  Thr Ala Thr Pro Pro  Gly Thr Ser Asp Pro  Phe Pro Glu 
    1820                 1825                 1830             


Ser Asn  Ser Pro Ile Ser Asp  Leu Gln Thr Glu Ile  Pro Asp Arg 
    1835                 1840                 1845             


Ala Trp  Asn Ser Gly Tyr Glu  Trp Ile Thr Glu Tyr  Thr Gly Lys 
    1850                 1855                 1860             


Thr Val  Trp Phe Val Pro Ser  Val Lys Met Gly Asn  Glu Ile Ala 
    1865                 1870                 1875             


Leu Cys  Leu Gln Arg Ala Gly  Lys Lys Val Val Gln  Leu Asn Arg 
    1880                 1885                 1890             


Lys Ser  Tyr Glu Thr Glu Tyr  Pro Lys Cys Lys Asn  Asp Asp Trp 
    1895                 1900                 1905             


Asp Phe  Val Ile Thr Thr Asp  Ile Ser Glu Met Gly  Ala Asn Phe 
    1910                 1915                 1920             


Lys Ala  Ser Arg Val Ile Asp  Ser Arg Lys Ser Val  Lys Pro Thr 
    1925                 1930                 1935             


Ile Ile  Thr Glu Gly Glu Gly  Arg Val Ile Leu Gly  Glu Pro Ser 
    1940                 1945                 1950             


Ala Val  Thr Ala Ala Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly 
    1955                 1960                 1965             


Arg Asn  Pro Ser Gln Val Gly  Asp Glu Tyr Cys Tyr  Gly Gly His 
    1970                 1975                 1980             


Thr Asn  Glu Asp Asp Ser Asn  Phe Ala His Trp Thr  Glu Ala Arg 
    1985                 1990                 1995             


Ile Met  Leu Asp Asn Ile Asn  Met Pro Asn Gly Leu  Ile Ala Gln 
    2000                 2005                 2010             


Phe Tyr  Gln Pro Glu Arg Glu  Lys Val Tyr Thr Met  Asp Gly Glu 
    2015                 2020                 2025             


Tyr Arg  Leu Arg Gly Glu Glu  Arg Lys Asn Phe Leu  Glu Leu Leu 
    2030                 2035                 2040             


Arg Thr  Ala Asp Leu Pro Val  Trp Leu Ala Tyr Lys  Val Ala Ala 
    2045                 2050                 2055             


Ala Gly  Val Ser Tyr His Asp  Arg Arg Trp Cys Phe  Asp Gly Pro 
    2060                 2065                 2070             


Arg Thr  Asn Thr Ile Leu Glu  Asp Asn Asn Glu Val  Glu Val Ile 
    2075                 2080                 2085             


Thr Lys  Leu Gly Glu Arg Lys  Ile Leu Arg Pro Arg  Trp Ile Asp 
    2090                 2095                 2100             


Ala Arg  Val Tyr Ser Asp His  Gln Ala Leu Lys Ala  Phe Lys Asp 
    2105                 2110                 2115             


Phe Ala  Ser Gly Lys Arg Ser  Gln Ile Gly Leu Ile  Glu Val Leu 
    2120                 2125                 2130             


Gly Lys  Met Pro Glu His Phe  Met Gly Lys Thr Trp  Glu Ala Leu 
    2135                 2140                 2145             


Asp Thr  Met Tyr Val Val Ala  Thr Ala Glu Lys Gly  Gly Arg Ala 
    2150                 2155                 2160             


His Arg  Met Ala Leu Glu Glu  Leu Pro Asp Ala Leu  Gln Thr Ile 
    2165                 2170                 2175             


Ala Leu  Ile Ala Leu Leu Ser  Val Met Thr Met Gly  Val Phe Phe 
    2180                 2185                 2190             


Leu Leu  Met Gln Arg Lys Gly  Ile Gly Lys Ile Gly  Leu Gly Gly 
    2195                 2200                 2205             


Ala Val  Leu Gly Val Ala Thr  Phe Phe Cys Trp Met  Ala Glu Val 
    2210                 2215                 2220             


Pro Gly  Thr Lys Ile Ala Gly  Met Leu Leu Leu Ser  Leu Leu Leu 
    2225                 2230                 2235             


Met Ile  Val Leu Ile Pro Glu  Pro Glu Lys Gln Arg  Ser Gln Thr 
    2240                 2245                 2250             


Asp Asn  Gln Leu Ala Val Phe  Leu Ile Cys Val Met  Thr Leu Val 
    2255                 2260                 2265             


Ser Ala  Val Ala Ala Asn Glu  Met Gly Trp Leu Asp  Lys Thr Lys 
    2270                 2275                 2280             


Ser Asp  Ile Ser Ser Leu Phe  Gly Gln Arg Ile Glu  Val Lys Glu 
    2285                 2290                 2295             


Asn Phe  Ser Met Gly Glu Phe  Leu Leu Asp Leu Arg  Pro Ala Thr 
    2300                 2305                 2310             


Ala Trp  Ser Leu Tyr Ala Val  Thr Thr Ala Val Leu  Thr Pro Leu 
    2315                 2320                 2325             


Leu Lys  His Leu Ile Thr Ser  Asp Tyr Ile Asn Thr  Ser Leu Thr 
    2330                 2335                 2340             


Ser Ile  Asn Val Gln Ala Ser  Ala Leu Phe Thr Leu  Ala Arg Gly 
    2345                 2350                 2355             


Phe Pro  Phe Val Asp Val Gly  Val Ser Ala Leu Leu  Leu Ala Ala 
    2360                 2365                 2370             


Gly Cys  Trp Gly Gln Val Thr  Leu Thr Val Thr Val  Thr Ala Ala 
    2375                 2380                 2385             


Thr Leu  Leu Phe Cys His Tyr  Ala Tyr Met Val Pro  Gly Trp Gln 
    2390                 2395                 2400             


Ala Glu  Ala Met Arg Ser Ala  Gln Arg Arg Thr Ala  Ala Gly Ile 
    2405                 2410                 2415             


Met Lys  Asn Ala Val Val Asp  Gly Ile Val Ala Thr  Asp Val Pro 
    2420                 2425                 2430             


Glu Leu  Glu Arg Thr Thr Pro  Ile Met Gln Lys Lys  Val Gly Gln 
    2435                 2440                 2445             


Ile Met  Leu Ile Leu Val Ser  Leu Ala Ala Val Val  Val Asn Pro 
    2450                 2455                 2460             


Ser Val  Lys Thr Val Arg Glu  Ala Gly Ile Leu Ile  Thr Ala Ala 
    2465                 2470                 2475             


Ala Val  Thr Leu Trp Glu Asn  Gly Ala Ser Ser Val  Trp Asn Ala 
    2480                 2485                 2490             


Thr Thr  Ala Ile Gly Leu Cys  His Ile Met Arg Gly  Gly Trp Leu 
    2495                 2500                 2505             


Ser Cys  Leu Ser Ile Thr Trp  Thr Leu Ile Lys Asn  Met Glu Lys 
    2510                 2515                 2520             


Pro Gly  Leu Lys Arg Gly Gly  Ala Lys Gly Arg Thr  Leu Gly Glu 
    2525                 2530                 2535             


Val Trp  Lys Glu Arg Leu Asn  Gln Met Thr Lys Glu  Glu Phe Thr 
    2540                 2545                 2550             


Arg Tyr  Arg Lys Glu Ala Ile  Ile Glu Val Asp Arg  Ser Ala Ala 
    2555                 2560                 2565             


Lys His  Ala Arg Lys Glu Gly  Asn Val Thr Gly Gly  His Pro Val 
    2570                 2575                 2580             


Ser Arg  Gly Thr Ala Lys Leu  Arg Trp Leu Val Glu  Arg Arg Phe 
    2585                 2590                 2595             


Leu Glu  Pro Val Gly Lys Val  Ile Asp Leu Gly Cys  Gly Arg Gly 
    2600                 2605                 2610             


Gly Trp  Cys Tyr Tyr Met Ala  Thr Gln Lys Arg Val  Gln Glu Val 
    2615                 2620                 2625             


Arg Gly  Tyr Thr Lys Gly Gly  Pro Gly His Glu Glu  Pro Gln Leu 
    2630                 2635                 2640             


Val Gln  Ser Tyr Gly Trp Asn  Ile Val Thr Met Lys  Ser Gly Val 
    2645                 2650                 2655             


Asp Val  Phe Tyr Arg Pro Ser  Glu Cys Cys Asp Thr  Leu Leu Cys 
    2660                 2665                 2670             


Asp Ile  Gly Glu Ser Ser Ser  Ser Ala Glu Val Glu  Glu His Arg 
    2675                 2680                 2685             


Thr Ile  Arg Val Leu Glu Met  Val Glu Asp Trp Leu  His Arg Gly 
    2690                 2695                 2700             


Pro Arg  Glu Phe Cys Val Lys  Val Leu Cys Pro Tyr  Met Pro Lys 
    2705                 2710                 2715             


Val Ile  Glu Lys Met Glu Leu  Leu Gln Arg Arg Tyr  Gly Gly Gly 
    2720                 2725                 2730             


Leu Val  Arg Asn Pro Leu Ser  Arg Asn Ser Thr His  Glu Met Tyr 
    2735                 2740                 2745             


Trp Val  Ser Arg Ala Ser Gly  Asn Val Val His Ser  Val Asn Met 
    2750                 2755                 2760             


Thr Ser  Gln Val Leu Leu Gly  Arg Met Glu Lys Arg  Thr Trp Lys 
    2765                 2770                 2775             


Gly Pro  Gln Tyr Glu Glu Asp  Val Asn Leu Gly Ser  Gly Thr Arg 
    2780                 2785                 2790             


Ala Val  Gly Lys Pro Leu Leu  Asn Ser Asp Thr Ser  Lys Ile Lys 
    2795                 2800                 2805             


Asn Arg  Ile Glu Arg Leu Arg  Arg Glu Tyr Ser Ser  Thr Trp His 
    2810                 2815                 2820             


His Asp  Glu Asn His Pro Tyr  Arg Thr Trp Asn Tyr  His Gly Ser 
    2825                 2830                 2835             


Tyr Asp  Val Lys Pro Thr Gly  Ser Ala Ser Ser Leu  Val Asn Gly 
    2840                 2845                 2850             


Val Val  Arg Leu Leu Ser Lys  Pro Trp Asp Thr Ile  Thr Asn Val 
    2855                 2860                 2865             


Thr Thr  Met Ala Met Thr Asp  Thr Thr Pro Phe Gly  Gln Gln Arg 
    2870                 2875                 2880             


Val Phe  Lys Glu Lys Val Asp  Thr Lys Ala Pro Glu  Pro Pro Glu 
    2885                 2890                 2895             


Gly Val  Lys Tyr Val Leu Asn  Glu Thr Thr Asn Trp  Leu Trp Ala 
    2900                 2905                 2910             


Phe Leu  Ala Arg Glu Lys Arg  Pro Arg Met Cys Ser  Arg Glu Glu 
    2915                 2920                 2925             


Phe Ile  Arg Lys Val Asn Ser  Asn Ala Ala Leu Gly  Ala Met Phe 
    2930                 2935                 2940             


Glu Glu  Gln Asn Gln Trp Arg  Ser Ala Arg Glu Ala  Val Glu Asp 
    2945                 2950                 2955             


Pro Lys  Phe Trp Glu Met Val  Asp Glu Glu Arg Glu  Ala His Leu 
    2960                 2965                 2970             


Arg Gly  Glu Cys His Thr Cys  Ile Tyr Asn Met Met  Gly Lys Arg 
    2975                 2980                 2985             


Glu Lys  Lys Pro Gly Glu Phe  Gly Lys Ala Lys Gly  Ser Arg Ala 
    2990                 2995                 3000             


Ile Trp  Phe Met Trp Leu Gly  Ala Arg Phe Leu Glu  Phe Glu Ala 
    3005                 3010                 3015             


Leu Gly  Phe Leu Asn Glu Asp  His Trp Leu Gly Arg  Lys Asn Ser 
    3020                 3025                 3030             


Gly Gly  Gly Val Glu Gly Leu  Gly Leu Gln Lys Leu  Gly Tyr Ile 
    3035                 3040                 3045             


Leu Arg  Glu Val Gly Thr Arg  Pro Gly Gly Lys Ile  Tyr Ala Asp 
    3050                 3055                 3060             


Asp Thr  Ala Gly Trp Asp Thr  Arg Ile Thr Arg Ala  Asp Leu Glu 
    3065                 3070                 3075             


Asn Glu  Ala Lys Val Leu Glu  Leu Leu Asp Gly Glu  His Arg Arg 
    3080                 3085                 3090             


Leu Ala  Arg Ala Ile Ile Glu  Leu Thr Tyr Arg His  Lys Val Val 
    3095                 3100                 3105             


Lys Val  Met Arg Pro Ala Ala  Asp Gly Arg Thr Val  Met Asp Val 
    3110                 3115                 3120             


Ile Ser  Arg Glu Asp Gln Arg  Gly Ser Gly Gln Val  Val Thr Tyr 
    3125                 3130                 3135             


Ala Leu  Asn Thr Phe Thr Asn  Leu Ala Val Gln Leu  Val Arg Met 
    3140                 3145                 3150             


Met Glu  Gly Glu Gly Val Ile  Gly Pro Asp Asp Val  Glu Lys Leu 
    3155                 3160                 3165             


Thr Lys  Gly Lys Gly Pro Lys  Val Arg Thr Trp Leu  Phe Glu Asn 
    3170                 3175                 3180             


Gly Glu  Glu Arg Leu Ser Arg  Met Ala Val Ser Gly  Asp Asp Cys 
    3185                 3190                 3195             


Val Val  Lys Pro Leu Asp Asp  Arg Phe Ala Thr Ser  Leu His Phe 
    3200                 3205                 3210             


Leu Asn  Ala Met Ser Lys Val  Arg Lys Asp Ile Gln  Glu Trp Lys 
    3215                 3220                 3225             


Pro Ser  Thr Gly Trp Tyr Asp  Trp Gln Gln Val Pro  Phe Cys Ser 
    3230                 3235                 3240             


Asn His  Phe Thr Glu Leu Ile  Met Lys Asp Gly Arg  Thr Leu Val 
    3245                 3250                 3255             


Val Pro  Cys Arg Gly Gln Asp  Glu Leu Val Gly Arg  Ala Arg Ile 
    3260                 3265                 3270             


Ser Pro  Gly Ala Gly Trp Asn  Val Arg Asp Thr Ala  Cys Leu Ala 
    3275                 3280                 3285             


Lys Ser  Tyr Ala Gln Met Trp  Leu Leu Leu Tyr Phe  His Arg Arg 
    3290                 3295                 3300             


Asp Leu  Arg Leu Met Ala Asn  Ala Ile Cys Ser Ala  Val Pro Val 
    3305                 3310                 3315             


Asn Trp  Val Pro Thr Gly Arg  Thr Thr Trp Ser Ile  His Ala Gly 
    3320                 3325                 3330             


Gly Glu  Trp Met Thr Thr Glu  Asp Met Leu Glu Val  Trp Asn Arg 
    3335                 3340                 3345             


Val Trp  Ile Glu Glu Asn Glu  Trp Met Glu Asp Lys  Thr Pro Val 
    3350                 3355                 3360             


Glu Lys  Trp Ser Asp Val Pro  Tyr Ser Gly Lys Arg  Glu Asp Ile 
    3365                 3370                 3375             


Trp Cys  Gly Ser Leu Ile Gly  Thr Arg Ala Arg Ala  Thr Trp Ala 
    3380                 3385                 3390             


Glu Asn  Ile Gln Val Ala Ile  Asn Gln Val Arg Ala  Ile Ile Gly 
    3395                 3400                 3405             


Asp Glu  Lys Tyr Val Asp Tyr  Met Ser Ser Leu Lys  Arg Tyr Glu 
    3410                 3415                 3420             


Asp Thr  Thr Leu Val Glu Asp  Thr Val Leu 
    3425                 3430             


<210>  19
<211>  11905
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
agtagttcgc ctgtgtgagc tgacaaactt agtagtgttt gtgaggatta acaacaatta       60

acacagtgcg agctgtttct tagcacgaag atctcgatgt ctaagaaacc aggagggccc      120

ggcaagagcc gggctgtcaa tatgctaaaa cgcggaatgc cccgcgtgtt gtccttgatt      180

ggactgaaga gggctatgtt gatggctcag tcaaagcacg gtctaacaaa agaaatgaca      240

atgaaatacc gtatggaagg gtgcgtcgat ggacataaat ttgtgatcac gggagagggc      300

attggatatc cgttcaaagg gaaacaggct attaatctgt gtgtggtcga aggtggacca      360

ttgccatttg ccgaagacat attgtcagct gcctttatgt acggaaacag ggttttcact      420

gaatatcctc aagacatagc tgactatttc aagaactcgt gtcctgctgg ttatacatgg      480

gacaggtctt ttctctttga ggatggagca gtttgcatat gtaatgcaga tataacagtg      540

agtgttgaag aaaactgcat gtatcatgag tccaaatttt atggagtgaa ttttcctgct      600

gatggacctg tgatgaaaaa gatgacagat aactgggagc catcctgcga gaagatcata      660

ccagtaccta agcaggggat attgaaaggg gatgtctcca tgtacctcct tctgaaggat      720

ggtgggcgtt tacggtgcca attcgacaca gtttacaaag caaagtctgt gccaagaaag      780

atgccggact ggcacttcat ccagcataag ctcacccgtg aagaccgcag cgatgctaag      840

aatcagaaat ggcatctgac agaacatgct attgcatccg gatctgcatt gcccggaagc      900

ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct      960

atgtccaaaa agcccggcgg tcctgggaaa tccagagccg tgaacatgtt gaaaaggggg     1020

atgccacggg tactgagtct gatcggcctc aaaagagcca tgttgagcct gatcgacggc     1080

aaggggccaa tacgatttgt gttggctctc ttggcgttct tcaggttcac agcaattgct     1140

ccgacccgag cagtgctgga tcgatggaga ggtgtgaaca aacaaacagc gatgaaacac     1200

cttctgagtt ttaagaagga actagggacc ttgaccagtg ctatcaatcg gcggagttcg     1260

aaacaaaaga aaagaggagg aaagaccgga attgcagtca tgattggcct gatcgccagc     1320

gctatggcag cggaggtcac tagacgtggg agtgcatact atatgtactt ggacagaaac     1380

gatgctgggg aggccatatc ttttccaacc acattgggga tgaataagtg ttatatacag     1440

atcatggatc ttggacacat gtgtgatgcc accatgagct atgaatgccc tatgctggat     1500

gagggggtgg aaccagatga cgtcgattgt tggtgcaaca cgacgtcaac ttgggttgtg     1560

tacggaacct gccatcacaa aaaaggtgaa gcacggagaa gtagaagagc tgtgacgctc     1620

ccctcccatt ccactaggaa gctgcaaacg cggtcgcaaa cctggttgga atcaagagaa     1680

tacacaaagc acttgattag agtcgaaaat tggatattca ggaaccctgg cttcgcgtta     1740

gcagcagctg ccatcgcttg gcttttggga agctcaacga gccaaaaagt catatacttg     1800

gtcatgatac tgctgattgc cccggcatac agcatcaggt gcataggagt cagcaatagg     1860

gactttgtgg aaggtatgtc aggtgggact tgggttgatg ttgtcttgga acatggaggt     1920

tgtgtcaccg taatggcaca ggacaaaccg actgtcgaca tagagctggt tacaacaaca     1980

gtcagcaaca tggcggaggt aagatcctac tgctatgagg catcaatatc agacatggct     2040

tcggacagcc gctgcccaac acaaggtgaa gcctaccttg acaagcaatc agacactcaa     2100

tatgtctgca aaagaacgtt agtggacaga ggctggggaa atggatgtgg actttttggc     2160

aaagggagtc tggtgacatg cgctaagttt gcatgctcca agaaaatgac cgggaagagc     2220

atccagccag agaatctgga gtaccggata atgctgtcag ttcatggctc ccagcacagt     2280

gggatgatcg ttaatgacac aggacatgaa actgatgaga atagagcgaa ggttgagata     2340

acgcccaatt caccaagagc cgaagccacc ctggggggtt ttggaagcct aggacttgat     2400

tgtgaaccga ggacaggcct tgacttttca gatttgtatt acttgactat gaataacaag     2460

cactggttgg ttcacaagga gtggttccac gacattccat taccttggca cgctggggca     2520

gacaccggaa ctccacactg gaacaacaaa gaagcactgg tagagttcaa ggacgcacat     2580

gccaaaaggc aaactgtcgt ggttctaggg agtcaagaag gagcagttca cacggccctt     2640

gctggagctc tggaggctga gatggatggt gcaaagggaa ggctgtcctc tggccacttg     2700

aaatgtcgcc tgaaaatgga taaacttaga ttgaagggcg tgtcatactc cttgtgtacc     2760

gcagcgttca cattcaccaa gatcccggct gaaacactgc acgggacagt cacagtggag     2820

gtacagtacg cagggacaga tggaccttgc aaggttccag ctcagatggc ggtggacatg     2880

caaactctga ccccagttgg gaggttgata accgctaacc ccgtaatcac tgaaagcact     2940

gagaactcta agatgatgct ggaacttgat ccaccatttg gggactctta cattgtcata     3000

ggagtcgggg agaagaagat cacccaccac tggcacagga gtggcagcac cattggaaaa     3060

gcatttgaag ccactgtgag aggtgccaag agaatggcag tcttgggaga cacagcctgg     3120

gactttggat cagttggagg cgctctcaac tcattgggca agggcatcca tcaaattttt     3180

ggagcagctt tcaaatcatt gtttggagga atgtcctggt tctcacaaat tctcattgga     3240

acgttgctga tgtggttggg tctgaacaca aagaatggat ctatttccct tatgtgcttg     3300

gccttagggg gagtgttgat cttcttatcc acagccgtct ctgctgattc cggatgtgcc     3360

atagacatca gccggcaaga gctgagatgt ggaagtggag tgttcataca caatgatgtg     3420

gaggcttgga tggaccggta caagtattac cctgaaacgc cacaaggcct agccaagatc     3480

attcagaaag ctcataagga aggagtgtgc ggtctacgat cagtttccag actggagcat     3540

caaatgtggg aagcagtgaa ggacgagctg aacactcttt tgaaggagaa tggtgtggac     3600

cttagtgtcg tggttgagaa acaggaggga atgtacaagt cagcacctaa acgcctcacc     3660

gccaccacgg aaaaattgga aattggctgg aaggcctggg gaaagagtat tttatttgca     3720

ccagaactcg ccaacaacac ctttgtggtt gatggtccgg agaccaagga atgtccgact     3780

cagaatcgcg cttggaatag cttagaagtg gaggattttg gatttggtct caccagcact     3840

cggatgttcc tgaaggtcag agagagcaac acaactgaat gtgactcgaa gatcattgga     3900

acggctgtca agaacaactt ggcgatccac agtgacctgt cctattggat tgaaagcagg     3960

ctcaatgata cgtggaagct tgaaagggca gttctgggtg aagtcaaatc atgtacgtgg     4020

cctgagacgc ataccttgtg gggcgatgga atccttgaga gtgacttgat aataccagtc     4080

acactggcgg gaccacgaag caatcacaat cggagacctg ggtacaagac acaaaaccag     4140

ggcccatggg acgaaggccg ggtagagatt gacttcgatt actgcccagg aactacggtc     4200

accctgagtg agagctgcgg acaccgtgga cctgccactc gcaccaccac agagagcgga     4260

aagttgataa cagattggtg ctgcaggagc tgcaccttac caccactgcg ctaccaaact     4320

gacagcggct gttggtatgg tatggagatc agaccacaga gacatgatga aaagaccctc     4380

gtgcagtcac aagtgaatgc ttataatgct gatatgattg acccttttca gttgggcctt     4440

ctggtcgtgt tcttggccac ccaggaggtc cttcgcaaga ggtggacagc caagatcagc     4500

atgccagcta tactgattgc tctgctagtc ctggtgtttg ggggcattac ttacactgat     4560

gtgttacgct atgtcatctt ggtgggggca gctttcgcag aatctaattc gggaggagac     4620

gtggtacact tggcgctcat ggcgaccttc aagatacaac cagtgtttat ggtggcatcg     4680

tttctcaaag cgagatggac caaccaggag aacattttgt tgatgttggc ggctgttttc     4740

tttcaaatgg cttattacga tgcccgccaa attctgctct gggagatccc tgatgtgttg     4800

aattcactgg cggtagcttg gatgatactg agagccataa cattcacaac gacatcaaac     4860

gtggttgttc cgctgctagc cctgctaaca cccgggctga gatgcttgaa tctggatgtg     4920

tacaggatac tgctgttgat ggtcggaata ggcagcttga tcagggagaa gaggagtgca     4980

gctgcaaaaa agaaaggagc aagtctgcta tgcttggctc tagcctcaac aggacttttc     5040

aaccccatga tccttgctgc tggactgatt gcatgtgatc ccaaccgtaa acgcggatgg     5100

cccgcaactg aagtgatgac agctgtcggc ctaatgtttg ccatcgtcgg agggctggca     5160

gagcttgaca ttgactccat ggccattcca atgactatcg cggggctcat gtttgctgct     5220

ttcgtgattt ctgggaaatc aacagatatg tggattgaga gaacggcgga catttcctgg     5280

gaaagtgatg cagaaattac aggctcgagc gaaagagttg atgtgcggct tgatgatgat     5340

ggaaacttcc agctcatgaa tgatccagga gcaccttgga agatatggat gctcagaatg     5400

gtctgtctcg cgattagtgc gtacaccccc tgggcaatct tgccctcagt agttggattt     5460

tggataactc tccaatacac aaagagagga ggcgtgttgt gggacactcc ctcaccaaag     5520

gagtacaaaa agggggacac gaccaccggc gtctacagga tcatgactcg tgggctgctc     5580

ggcagttatc aagcaggagc gggcgtgatg gttgaaggtg ttttccacac cctttggcat     5640

acaacaaaag gagccgcttt gatgagcgga gagggccgcc tggacccata ctggggcagt     5700

gtcaaggagg atcgactttg ttacggagga ccctggaaat tgcagcacaa gtggaacggg     5760

caggatgagg tgcagatgat tgtggtggaa cctggcagga acgttaagaa cgtccagacg     5820

aaaccagggg tgttcaaaac acctgaagga gaaatcgggg ccgtgacttt ggacttcccc     5880

actggaacat caggctcacc aatagtggac aaaaacggtg atgtgattgg gctttatggc     5940

aatggagtca taatgcccaa cggctcatac ataagcgcga tagtgcaggg tgaaaggatg     6000

gatgagccaa tcccagccgg attcgaacct gagatgctga ggaaaaaaca gatcactgta     6060

ctggatctcc atcccggcgc cggtaaaaca aggaggattc tgccacagat catcaaagag     6120

gccataaaca gaagactgag aacagccgtg ctagcaccaa ccagggttgt ggctgctgag     6180

atggctgaag cactgagagg actgcccatc cggtaccaga catccgcagt gcccagagaa     6240

cataatggaa atgagattgt tgatgtcatg tgtcatgcta ccctcaccca caggctgatg     6300

tctcctcaca gggtgccgaa ctacaacctg ttcgtgatgg atgaggctca tttcaccgac     6360

ccagctagca ttgcagcaag aggttacatt tccacaaagg tcgagctagg ggaggcggcg     6420

gcaatattca tgacagccac cccaccaggc acttcagatc cattcccaga gtccaattca     6480

ccaatttccg acttacagac tgagatcccg gatcgagctt ggaactctgg atacgaatgg     6540

atcacagaat acaccgggaa gacggtttgg tttgtgccta gtgtcaagat ggggaatgag     6600

attgcccttt gcctacaacg tgctggaaag aaagtagtcc aattgaacag aaagtcgtac     6660

gagacggagt acccaaaatg taagaacgat gattgggact ttgttatcac aacagacata     6720

tctgaaatgg gggctaactt caaggcgagc agggtgattg acagccggaa gagtgtgaaa     6780

ccaaccatca taacagaagg agaagggaga gtgatcctgg gagaaccatc tgcagtgaca     6840

gcagctagtg ccgcccagag acgtggacgt atcggtagaa atccgtcgca agttggtgat     6900

gagtactgtt atggggggca cacgaatgaa gacgactcga acttcgccca ttggactgag     6960

gcacgaatca tgctggacaa catcaacatg ccaaacggac tgatcgctca attctaccaa     7020

ccagagcgtg agaaggtata taccatggat ggggaatacc ggctcagagg agaagagaga     7080

aaaaactttc tggaactgtt gaggactgca gatctgccag tttggctggc ttacaaggtt     7140

gcagcggctg gagtgtcata ccacgaccgg aggtggtgct ttgatggtcc taggacaaac     7200

acaattttag aagacaacaa cgaagtggaa gtcatcacga agcttggtga aaggaagatt     7260

ctgaggccgc gctggattga cgccagggtg tactcggatc accaggcact aaaggcgttc     7320

aaggacttcg cctcgggaaa acgttctcag atagggctca ttgaggttct gggaaagatg     7380

cctgagcact tcatggggaa gacatgggaa gcacttgaca ccatgtacgt tgtggccact     7440

gcagagaaag gaggaagagc tcacagaatg gccctggagg aactgccaga tgctcttcag     7500

acaattgcct tgattgcctt attgagtgtg atgaccatgg gagtattctt cctcctcatg     7560

cagcggaagg gcattggaaa gataggtttg ggaggcgctg tcttgggagt cgcgaccttt     7620

ttctgttgga tggctgaagt tccaggaacg aagatcgccg gaatgttgct gctctccctt     7680

ctcttgatga ttgtgctaat tcctgagcca gagaagcaac gttcgcagac agacaaccag     7740

ctagccgtgt tcctgatttg tgtcatgacc cttgtgagcg cagtggcagc caacgagatg     7800

ggttggctag ataagaccaa gagtgacata agcagtttgt ttgggcaaag aattgaggtc     7860

aaggagaatt tcagcatggg agagtttctt ttggacttga ggcctgcaac agcctggtca     7920

ctgtacgctg tgacaacagc ggtcctcact ccactgctaa agcatttgat cacgtcagat     7980

tacatcaaca cctcattgac ctcaataaac gttcaggcaa gtgcactatt cacactcgcg     8040

cgaggcttcc ccttcgtcga tgttggagtg tcggctctcc tgctagcagc cggatgctgg     8100

ggacaagtca ccctcaccgt tacggtaaca gcggcaacac tccttttttg ccactatgcc     8160

tacatggttc ccggttggca agctgaggca atgcgctcag cccagcggcg gacagcggcc     8220

ggaatcatga agaacgctgt agtggatggc atcgtggcca cggacgtccc agaattagag     8280

cgcaccacac ccatcatgca gaagaaagtt ggacagatca tgctgatctt ggtgtctcta     8340

gctgcagtag tagtgaaccc gtctgtgaag acagtacgag aagccggaat tttgatcacg     8400

gccgcagcgg tgacgctttg ggagaatgga gcaagctctg tttggaacgc aacaactgcc     8460

atcggactct gccacatcat gcgtgggggt tggttgtcat gtctatccat aacatggaca     8520

ctcataaaga acatggaaaa accaggacta aaaagaggtg gggcaaaagg acgcaccttg     8580

ggagaggttt ggaaagaaag actcaaccag atgacaaaag aagagttcac taggtaccgc     8640

aaagaggcca tcatcgaagt cgatcgctca gcggcaaaac acgccaggaa agaaggcaat     8700

gtcactggag ggcatccagt ctctaggggc acagcaaaac tgagatggct ggtcgaacgg     8760

aggtttctcg aaccggtcgg aaaagtgatt gaccttggat gtggaagagg cggttggtgt     8820

tactatatgg caacccaaaa aagagtccaa gaagtcagag ggtacacaaa gggcggtccc     8880

ggacatgaag agccccaact agtgcaaagt tatggatgga acattgtcac catgaagagt     8940

ggagtggatg tgttctacag accttctgag tgttgtgaca ccctcctttg tgacatcgga     9000

gagtcctcgt caagtgctga ggttgaagag cataggacga ttcgggtcct tgaaatggtt     9060

gaggactggc tgcaccgagg gccaagggaa ttttgcgtga aggtgctctg cccctacatg     9120

ccgaaagtca tagagaagat ggagctgctc caacgccggt atgggggggg actggtcaga     9180

aacccactct cacggaattc cacgcacgag atgtattggg tgagtcgagc ttcaggcaat     9240

gtggtacatt cagtgaatat gaccagccag gtgctcctag gaagaatgga aaaaaggacc     9300

tggaagggac cccaatacga ggaagatgta aacttgggaa gtggaaccag ggcggtggga     9360

aaacccctgc tcaactcaga caccagtaaa atcaagaaca ggattgaacg actcaggcgt     9420

gagtacagtt cgacgtggca ccacgatgag aaccacccat atagaacctg gaactatcac     9480

ggcagttatg atgtgaagcc cacaggctcc gccagttcgc tggtcaatgg agtggtcagg     9540

ctcctctcaa aaccatggga caccatcacg aatgttacca ccatggccat gactgacact     9600

actcccttcg ggcagcagcg agtgttcaaa gagaaggtgg acacgaaagc tcctgaaccg     9660

ccagaaggag tgaagtacgt gctcaacgag accaccaact ggttgtgggc gtttttggcc     9720

agagaaaaac gtcccagaat gtgctctcga gaggaattca taagaaaggt caacagcaat     9780

gcagctttgg gtgccatgtt tgaagagcag aatcaatgga ggagcgccag agaagcagtt     9840

gaagatccaa aattttggga gatggtggat gaggagcgcg aggcacatct gcggggggaa     9900

tgtcacactt gcatttacaa catgatggga aagagagaga aaaaacccgg agagttcgga     9960

aaggccaagg gaagcagagc catttggttc atgtggctcg gagctcgctt tctggagttc    10020

gaggctctgg gttttctcaa tgaagaccac tggcttggaa gaaagaactc aggaggaggt    10080

gtcgagggct tgggcctcca aaaactgggt tacatcctgc gtgaagttgg cacccggcct    10140

gggggcaaga tctatgctga tgacacagct ggctgggaca cccgcatcac gagagctgac    10200

ttggaaaatg aagctaaggt gcttgagctg cttgatgggg aacatcggcg tcttgccagg    10260

gccatcattg agctcaccta tcgtcacaaa gttgtgaaag tgatgcgccc ggctgctgat    10320

ggaagaaccg tcatggatgt tatctccaga gaagatcaga gggggagtgg acaagttgtc    10380

acctacgccc taaacacttt caccaacctg gccgtccagc tggtgaggat gatggaaggg    10440

gaaggagtga ttggcccaga tgatgtggag aaactcacaa aagggaaagg acccaaagtc    10500

aggacctggc tgtttgagaa tggggaagaa agactcagcc gcatggctgt cagtggagat    10560

gactgtgtgg taaagcccct ggacgatcgc tttgccacct cgctccactt cctcaatgct    10620

atgtcaaagg ttcgcaaaga catccaagag tggaaaccgt caactggatg gtatgattgg    10680

cagcaggttc cattttgctc aaaccatttc actgaattga tcatgaaaga tggaagaaca    10740

ctggtggttc catgccgagg acaggatgaa ttggtaggca gagctcgcat atctccaggg    10800

gccggatgga acgtccgcga cactgcttgt ctggctaagt cttatgccca gatgtggctg    10860

cttctgtact tccacagaag agacctgcgg ctcatggcca acgccatttg ctccgctgtc    10920

cctgtgaatt gggtccctac cggaagaacc acgtggtcca tccatgcagg aggagagtgg    10980

atgacaacag aggacatgtt ggaggtctgg aaccgtgttt ggatagagga gaatgaatgg    11040

atggaagaca aaaccccagt ggagaaatgg agtgacgtcc catattcagg aaaacgagag    11100

gacatctggt gtggcagcct gattggcaca agagcccgag ccacgtgggc agaaaacatc    11160

caggtggcta tcaaccaagt cagagcaatc atcggagatg agaagtatgt ggattacatg    11220

agttcactaa agagatatga agacacaact ttggttgagg acacagtact gtagatattt    11280

aatcaattgt aaatagacaa tataagtatg cataaaagtg tagttttata gtagtattta    11340

gtggtgttag tgtaaatagt taagaaaatt ttgaggagaa agtcaggccg ggaagttccc    11400

gccaccggaa gttgagtaga cggtgctgcc tgcgactcaa ccccaggagg actgggtgaa    11460

caaagccgcg aagtgatcca tgtaagccct cagaaccgtc tcggaaggag gaccccacat    11520

gttgtaactt caaagcccaa tgtcagacca cgctacggcg tgctactctg cggagagtgc    11580

agtctgcgat agtgccccag gaggactggg ttaacaaagg caaaccaacg ccccacgcgg    11640

ccctagcccc ggtaatggtg ttaaccaggg cgaaaggact agaggttaga ggagaccccg    11700

cggtttaaag tgcacggccc agcctggctg aagctgtagg tcaggggaag gactagaggt    11760

tagtggagac cccgtgccac aaaacaccac aacaaaacag catattgaca cctgggatag    11820

actaggagat cttctgctct gcacaaccag ccacacggca cagtgcgccg acaatggtgg    11880

ctggtggtgc gagaacacag gatct                                          11905


<210>  20
<211>  3725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
            20                  25                  30          


Ala Met Leu Met Ala Gln Ser Lys His Gly Leu Thr Lys Glu Met Thr 
        35                  40                  45              


Met Lys Tyr Arg Met Glu Gly Cys Val Asp Gly His Lys Phe Val Ile 
    50                  55                  60                  


Thr Gly Glu Gly Ile Gly Tyr Pro Phe Lys Gly Lys Gln Ala Ile Asn 
65                  70                  75                  80  


Leu Cys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Glu Asp Ile Leu 
                85                  90                  95      


Ser Ala Ala Phe Met Tyr Gly Asn Arg Val Phe Thr Glu Tyr Pro Gln 
            100                 105                 110         


Asp Ile Ala Asp Tyr Phe Lys Asn Ser Cys Pro Ala Gly Tyr Thr Trp 
        115                 120                 125             


Asp Arg Ser Phe Leu Phe Glu Asp Gly Ala Val Cys Ile Cys Asn Ala 
    130                 135                 140                 


Asp Ile Thr Val Ser Val Glu Glu Asn Cys Met Tyr His Glu Ser Lys 
145                 150                 155                 160 


Phe Tyr Gly Val Asn Phe Pro Ala Asp Gly Pro Val Met Lys Lys Met 
                165                 170                 175     


Thr Asp Asn Trp Glu Pro Ser Cys Glu Lys Ile Ile Pro Val Pro Lys 
            180                 185                 190         


Gln Gly Ile Leu Lys Gly Asp Val Ser Met Tyr Leu Leu Leu Lys Asp 
        195                 200                 205             


Gly Gly Arg Leu Arg Cys Gln Phe Asp Thr Val Tyr Lys Ala Lys Ser 
    210                 215                 220                 


Val Pro Arg Lys Met Pro Asp Trp His Phe Ile Gln His Lys Leu Thr 
225                 230                 235                 240 


Arg Glu Asp Arg Ser Asp Ala Lys Asn Gln Lys Trp His Leu Thr Glu 
                245                 250                 255     


His Ala Ile Ala Ser Gly Ser Ala Leu Pro Gly Ser Gly Ala Thr Asn 
            260                 265                 270         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        275                 280                 285             


Met Ser Lys Lys Pro Gly Gly Pro Gly Lys Ser Arg Ala Val Asn Met 
    290                 295                 300                 


Leu Lys Arg Gly Met Pro Arg Val Leu Ser Leu Ile Gly Leu Lys Arg 
305                 310                 315                 320 


Ala Met Leu Ser Leu Ile Asp Gly Lys Gly Pro Ile Arg Phe Val Leu 
                325                 330                 335     


Ala Leu Leu Ala Phe Phe Arg Phe Thr Ala Ile Ala Pro Thr Arg Ala 
            340                 345                 350         


Val Leu Asp Arg Trp Arg Gly Val Asn Lys Gln Thr Ala Met Lys His 
        355                 360                 365             


Leu Leu Ser Phe Lys Lys Glu Leu Gly Thr Leu Thr Ser Ala Ile Asn 
    370                 375                 380                 


Arg Arg Ser Ser Lys Gln Lys Lys Arg Gly Gly Lys Thr Gly Ile Ala 
385                 390                 395                 400 


Val Met Ile Gly Leu Ile Ala Ser Ala Met Ala Ala Glu Val Thr Arg 
                405                 410                 415     


Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu 
            420                 425                 430         


Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln 
        435                 440                 445             


Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys 
    450                 455                 460                 


Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys 
465                 470                 475                 480 


Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys 
                485                 490                 495     


Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser 
            500                 505                 510         


Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu 
        515                 520                 525             


Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro 
    530                 535                 540                 


Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser 
545                 550                 555                 560 


Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro 
                565                 570                 575     


Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu 
            580                 585                 590         


Gly Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly 
        595                 600                 605             


Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu 
    610                 615                 620                 


Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr 
625                 630                 635                 640 


Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln 
                645                 650                 655     


Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys 
            660                 665                 670         


Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly 
        675                 680                 685             


Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met 
    690                 695                 700                 


Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu 
705                 710                 715                 720 


Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly 
                725                 730                 735     


His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser 
            740                 745                 750         


Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp 
        755                 760                 765             


Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr 
    770                 775                 780                 


Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile 
785                 790                 795                 800 


Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn 
                805                 810                 815     


Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln 
            820                 825                 830         


Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu 
        835                 840                 845             


Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser 
    850                 855                 860                 


Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys 
865                 870                 875                 880 


Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile 
                885                 890                 895     


Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala 
            900                 905                 910         


Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met 
        915                 920                 925             


Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile 
    930                 935                 940                 


Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro 
945                 950                 955                 960 


Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr 
                965                 970                 975     


His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala 
            980                 985                 990         


Thr Val Arg Gly Ala Lys Arg Met  Ala Val Leu Gly Asp  Thr Ala Trp 
        995                 1000                 1005             


Asp Phe  Gly Ser Val Gly Gly  Ala Leu Asn Ser Leu  Gly Lys Gly 
    1010                 1015                 1020             


Ile His  Gln Ile Phe Gly Ala  Ala Phe Lys Ser Leu  Phe Gly Gly 
    1025                 1030                 1035             


Met Ser  Trp Phe Ser Gln Ile  Leu Ile Gly Thr Leu  Leu Met Trp 
    1040                 1045                 1050             


Leu Gly  Leu Asn Thr Lys Asn  Gly Ser Ile Ser Leu  Met Cys Leu 
    1055                 1060                 1065             


Ala Leu  Gly Gly Val Leu Ile  Phe Leu Ser Thr Ala  Val Ser Ala 
    1070                 1075                 1080             


Asp Ser  Gly Cys Ala Ile Asp  Ile Ser Arg Gln Glu  Leu Arg Cys 
    1085                 1090                 1095             


Gly Ser  Gly Val Phe Ile His  Asn Asp Val Glu Ala  Trp Met Asp 
    1100                 1105                 1110             


Arg Tyr  Lys Tyr Tyr Pro Glu  Thr Pro Gln Gly Leu  Ala Lys Ile 
    1115                 1120                 1125             


Ile Gln  Lys Ala His Lys Glu  Gly Val Cys Gly Leu  Arg Ser Val 
    1130                 1135                 1140             


Ser Arg  Leu Glu His Gln Met  Trp Glu Ala Val Lys  Asp Glu Leu 
    1145                 1150                 1155             


Asn Thr  Leu Leu Lys Glu Asn  Gly Val Asp Leu Ser  Val Val Val 
    1160                 1165                 1170             


Glu Lys  Gln Glu Gly Met Tyr  Lys Ser Ala Pro Lys  Arg Leu Thr 
    1175                 1180                 1185             


Ala Thr  Thr Glu Lys Leu Glu  Ile Gly Trp Lys Ala  Trp Gly Lys 
    1190                 1195                 1200             


Ser Ile  Leu Phe Ala Pro Glu  Leu Ala Asn Asn Thr  Phe Val Val 
    1205                 1210                 1215             


Asp Gly  Pro Glu Thr Lys Glu  Cys Pro Thr Gln Asn  Arg Ala Trp 
    1220                 1225                 1230             


Asn Ser  Leu Glu Val Glu Asp  Phe Gly Phe Gly Leu  Thr Ser Thr 
    1235                 1240                 1245             


Arg Met  Phe Leu Lys Val Arg  Glu Ser Asn Thr Thr  Glu Cys Asp 
    1250                 1255                 1260             


Ser Lys  Ile Ile Gly Thr Ala  Val Lys Asn Asn Leu  Ala Ile His 
    1265                 1270                 1275             


Ser Asp  Leu Ser Tyr Trp Ile  Glu Ser Arg Leu Asn  Asp Thr Trp 
    1280                 1285                 1290             


Lys Leu  Glu Arg Ala Val Leu  Gly Glu Val Lys Ser  Cys Thr Trp 
    1295                 1300                 1305             


Pro Glu  Thr His Thr Leu Trp  Gly Asp Gly Ile Leu  Glu Ser Asp 
    1310                 1315                 1320             


Leu Ile  Ile Pro Val Thr Leu  Ala Gly Pro Arg Ser  Asn His Asn 
    1325                 1330                 1335             


Arg Arg  Pro Gly Tyr Lys Thr  Gln Asn Gln Gly Pro  Trp Asp Glu 
    1340                 1345                 1350             


Gly Arg  Val Glu Ile Asp Phe  Asp Tyr Cys Pro Gly  Thr Thr Val 
    1355                 1360                 1365             


Thr Leu  Ser Glu Ser Cys Gly  His Arg Gly Pro Ala  Thr Arg Thr 
    1370                 1375                 1380             


Thr Thr  Glu Ser Gly Lys Leu  Ile Thr Asp Trp Cys  Cys Arg Ser 
    1385                 1390                 1395             


Cys Thr  Leu Pro Pro Leu Arg  Tyr Gln Thr Asp Ser  Gly Cys Trp 
    1400                 1405                 1410             


Tyr Gly  Met Glu Ile Arg Pro  Gln Arg His Asp Glu  Lys Thr Leu 
    1415                 1420                 1425             


Val Gln  Ser Gln Val Asn Ala  Tyr Asn Ala Asp Met  Ile Asp Pro 
    1430                 1435                 1440             


Phe Gln  Leu Gly Leu Leu Val  Val Phe Leu Ala Thr  Gln Glu Val 
    1445                 1450                 1455             


Leu Arg  Lys Arg Trp Thr Ala  Lys Ile Ser Met Pro  Ala Ile Leu 
    1460                 1465                 1470             


Ile Ala  Leu Leu Val Leu Val  Phe Gly Gly Ile Thr  Tyr Thr Asp 
    1475                 1480                 1485             


Val Leu  Arg Tyr Val Ile Leu  Val Gly Ala Ala Phe  Ala Glu Ser 
    1490                 1495                 1500             


Asn Ser  Gly Gly Asp Val Val  His Leu Ala Leu Met  Ala Thr Phe 
    1505                 1510                 1515             


Lys Ile  Gln Pro Val Phe Met  Val Ala Ser Phe Leu  Lys Ala Arg 
    1520                 1525                 1530             


Trp Thr  Asn Gln Glu Asn Ile  Leu Leu Met Leu Ala  Ala Val Phe 
    1535                 1540                 1545             


Phe Gln  Met Ala Tyr Tyr Asp  Ala Arg Gln Ile Leu  Leu Trp Glu 
    1550                 1555                 1560             


Ile Pro  Asp Val Leu Asn Ser  Leu Ala Val Ala Trp  Met Ile Leu 
    1565                 1570                 1575             


Arg Ala  Ile Thr Phe Thr Thr  Thr Ser Asn Val Val  Val Pro Leu 
    1580                 1585                 1590             


Leu Ala  Leu Leu Thr Pro Gly  Leu Arg Cys Leu Asn  Leu Asp Val 
    1595                 1600                 1605             


Tyr Arg  Ile Leu Leu Leu Met  Val Gly Ile Gly Ser  Leu Ile Arg 
    1610                 1615                 1620             


Glu Lys  Arg Ser Ala Ala Ala  Lys Lys Lys Gly Ala  Ser Leu Leu 
    1625                 1630                 1635             


Cys Leu  Ala Leu Ala Ser Thr  Gly Leu Phe Asn Pro  Met Ile Leu 
    1640                 1645                 1650             


Ala Ala  Gly Leu Ile Ala Cys  Asp Pro Asn Arg Lys  Arg Gly Trp 
    1655                 1660                 1665             


Pro Ala  Thr Glu Val Met Thr  Ala Val Gly Leu Met  Phe Ala Ile 
    1670                 1675                 1680             


Val Gly  Gly Leu Ala Glu Leu  Asp Ile Asp Ser Met  Ala Ile Pro 
    1685                 1690                 1695             


Met Thr  Ile Ala Gly Leu Met  Phe Ala Ala Phe Val  Ile Ser Gly 
    1700                 1705                 1710             


Lys Ser  Thr Asp Met Trp Ile  Glu Arg Thr Ala Asp  Ile Ser Trp 
    1715                 1720                 1725             


Glu Ser  Asp Ala Glu Ile Thr  Gly Ser Ser Glu Arg  Val Asp Val 
    1730                 1735                 1740             


Arg Leu  Asp Asp Asp Gly Asn  Phe Gln Leu Met Asn  Asp Pro Gly 
    1745                 1750                 1755             


Ala Pro  Trp Lys Ile Trp Met  Leu Arg Met Val Cys  Leu Ala Ile 
    1760                 1765                 1770             


Ser Ala  Tyr Thr Pro Trp Ala  Ile Leu Pro Ser Val  Val Gly Phe 
    1775                 1780                 1785             


Trp Ile  Thr Leu Gln Tyr Thr  Lys Arg Gly Gly Val  Leu Trp Asp 
    1790                 1795                 1800             


Thr Pro  Ser Pro Lys Glu Tyr  Lys Lys Gly Asp Thr  Thr Thr Gly 
    1805                 1810                 1815             


Val Tyr  Arg Ile Met Thr Arg  Gly Leu Leu Gly Ser  Tyr Gln Ala 
    1820                 1825                 1830             


Gly Ala  Gly Val Met Val Glu  Gly Val Phe His Thr  Leu Trp His 
    1835                 1840                 1845             


Thr Thr  Lys Gly Ala Ala Leu  Met Ser Gly Glu Gly  Arg Leu Asp 
    1850                 1855                 1860             


Pro Tyr  Trp Gly Ser Val Lys  Glu Asp Arg Leu Cys  Tyr Gly Gly 
    1865                 1870                 1875             


Pro Trp  Lys Leu Gln His Lys  Trp Asn Gly Gln Asp  Glu Val Gln 
    1880                 1885                 1890             


Met Ile  Val Val Glu Pro Gly  Arg Asn Val Lys Asn  Val Gln Thr 
    1895                 1900                 1905             


Lys Pro  Gly Val Phe Lys Thr  Pro Glu Gly Glu Ile  Gly Ala Val 
    1910                 1915                 1920             


Thr Leu  Asp Phe Pro Thr Gly  Thr Ser Gly Ser Pro  Ile Val Asp 
    1925                 1930                 1935             


Lys Asn  Gly Asp Val Ile Gly  Leu Tyr Gly Asn Gly  Val Ile Met 
    1940                 1945                 1950             


Pro Asn  Gly Ser Tyr Ile Ser  Ala Ile Val Gln Gly  Glu Arg Met 
    1955                 1960                 1965             


Asp Glu  Pro Ile Pro Ala Gly  Phe Glu Pro Glu Met  Leu Arg Lys 
    1970                 1975                 1980             


Lys Gln  Ile Thr Val Leu Asp  Leu His Pro Gly Ala  Gly Lys Thr 
    1985                 1990                 1995             


Arg Arg  Ile Leu Pro Gln Ile  Ile Lys Glu Ala Ile  Asn Arg Arg 
    2000                 2005                 2010             


Leu Arg  Thr Ala Val Leu Ala  Pro Thr Arg Val Val  Ala Ala Glu 
    2015                 2020                 2025             


Met Ala  Glu Ala Leu Arg Gly  Leu Pro Ile Arg Tyr  Gln Thr Ser 
    2030                 2035                 2040             


Ala Val  Pro Arg Glu His Asn  Gly Asn Glu Ile Val  Asp Val Met 
    2045                 2050                 2055             


Cys His  Ala Thr Leu Thr His  Arg Leu Met Ser Pro  His Arg Val 
    2060                 2065                 2070             


Pro Asn  Tyr Asn Leu Phe Val  Met Asp Glu Ala His  Phe Thr Asp 
    2075                 2080                 2085             


Pro Ala  Ser Ile Ala Ala Arg  Gly Tyr Ile Ser Thr  Lys Val Glu 
    2090                 2095                 2100             


Leu Gly  Glu Ala Ala Ala Ile  Phe Met Thr Ala Thr  Pro Pro Gly 
    2105                 2110                 2115             


Thr Ser  Asp Pro Phe Pro Glu  Ser Asn Ser Pro Ile  Ser Asp Leu 
    2120                 2125                 2130             


Gln Thr  Glu Ile Pro Asp Arg  Ala Trp Asn Ser Gly  Tyr Glu Trp 
    2135                 2140                 2145             


Ile Thr  Glu Tyr Thr Gly Lys  Thr Val Trp Phe Val  Pro Ser Val 
    2150                 2155                 2160             


Lys Met  Gly Asn Glu Ile Ala  Leu Cys Leu Gln Arg  Ala Gly Lys 
    2165                 2170                 2175             


Lys Val  Val Gln Leu Asn Arg  Lys Ser Tyr Glu Thr  Glu Tyr Pro 
    2180                 2185                 2190             


Lys Cys  Lys Asn Asp Asp Trp  Asp Phe Val Ile Thr  Thr Asp Ile 
    2195                 2200                 2205             


Ser Glu  Met Gly Ala Asn Phe  Lys Ala Ser Arg Val  Ile Asp Ser 
    2210                 2215                 2220             


Arg Lys  Ser Val Lys Pro Thr  Ile Ile Thr Glu Gly  Glu Gly Arg 
    2225                 2230                 2235             


Val Ile  Leu Gly Glu Pro Ser  Ala Val Thr Ala Ala  Ser Ala Ala 
    2240                 2245                 2250             


Gln Arg  Arg Gly Arg Ile Gly  Arg Asn Pro Ser Gln  Val Gly Asp 
    2255                 2260                 2265             


Glu Tyr  Cys Tyr Gly Gly His  Thr Asn Glu Asp Asp  Ser Asn Phe 
    2270                 2275                 2280             


Ala His  Trp Thr Glu Ala Arg  Ile Met Leu Asp Asn  Ile Asn Met 
    2285                 2290                 2295             


Pro Asn  Gly Leu Ile Ala Gln  Phe Tyr Gln Pro Glu  Arg Glu Lys 
    2300                 2305                 2310             


Val Tyr  Thr Met Asp Gly Glu  Tyr Arg Leu Arg Gly  Glu Glu Arg 
    2315                 2320                 2325             


Lys Asn  Phe Leu Glu Leu Leu  Arg Thr Ala Asp Leu  Pro Val Trp 
    2330                 2335                 2340             


Leu Ala  Tyr Lys Val Ala Ala  Ala Gly Val Ser Tyr  His Asp Arg 
    2345                 2350                 2355             


Arg Trp  Cys Phe Asp Gly Pro  Arg Thr Asn Thr Ile  Leu Glu Asp 
    2360                 2365                 2370             


Asn Asn  Glu Val Glu Val Ile  Thr Lys Leu Gly Glu  Arg Lys Ile 
    2375                 2380                 2385             


Leu Arg  Pro Arg Trp Ile Asp  Ala Arg Val Tyr Ser  Asp His Gln 
    2390                 2395                 2400             


Ala Leu  Lys Ala Phe Lys Asp  Phe Ala Ser Gly Lys  Arg Ser Gln 
    2405                 2410                 2415             


Ile Gly  Leu Ile Glu Val Leu  Gly Lys Met Pro Glu  His Phe Met 
    2420                 2425                 2430             


Gly Lys  Thr Trp Glu Ala Leu  Asp Thr Met Tyr Val  Val Ala Thr 
    2435                 2440                 2445             


Ala Glu  Lys Gly Gly Arg Ala  His Arg Met Ala Leu  Glu Glu Leu 
    2450                 2455                 2460             


Pro Asp  Ala Leu Gln Thr Ile  Ala Leu Ile Ala Leu  Leu Ser Val 
    2465                 2470                 2475             


Met Thr  Met Gly Val Phe Phe  Leu Leu Met Gln Arg  Lys Gly Ile 
    2480                 2485                 2490             


Gly Lys  Ile Gly Leu Gly Gly  Ala Val Leu Gly Val  Ala Thr Phe 
    2495                 2500                 2505             


Phe Cys  Trp Met Ala Glu Val  Pro Gly Thr Lys Ile  Ala Gly Met 
    2510                 2515                 2520             


Leu Leu  Leu Ser Leu Leu Leu  Met Ile Val Leu Ile  Pro Glu Pro 
    2525                 2530                 2535             


Glu Lys  Gln Arg Ser Gln Thr  Asp Asn Gln Leu Ala  Val Phe Leu 
    2540                 2545                 2550             


Ile Cys  Val Met Thr Leu Val  Ser Ala Val Ala Ala  Asn Glu Met 
    2555                 2560                 2565             


Gly Trp  Leu Asp Lys Thr Lys  Ser Asp Ile Ser Ser  Leu Phe Gly 
    2570                 2575                 2580             


Gln Arg  Ile Glu Val Lys Glu  Asn Phe Ser Met Gly  Glu Phe Leu 
    2585                 2590                 2595             


Leu Asp  Leu Arg Pro Ala Thr  Ala Trp Ser Leu Tyr  Ala Val Thr 
    2600                 2605                 2610             


Thr Ala  Val Leu Thr Pro Leu  Leu Lys His Leu Ile  Thr Ser Asp 
    2615                 2620                 2625             


Tyr Ile  Asn Thr Ser Leu Thr  Ser Ile Asn Val Gln  Ala Ser Ala 
    2630                 2635                 2640             


Leu Phe  Thr Leu Ala Arg Gly  Phe Pro Phe Val Asp  Val Gly Val 
    2645                 2650                 2655             


Ser Ala  Leu Leu Leu Ala Ala  Gly Cys Trp Gly Gln  Val Thr Leu 
    2660                 2665                 2670             


Thr Val  Thr Val Thr Ala Ala  Thr Leu Leu Phe Cys  His Tyr Ala 
    2675                 2680                 2685             


Tyr Met  Val Pro Gly Trp Gln  Ala Glu Ala Met Arg  Ser Ala Gln 
    2690                 2695                 2700             


Arg Arg  Thr Ala Ala Gly Ile  Met Lys Asn Ala Val  Val Asp Gly 
    2705                 2710                 2715             


Ile Val  Ala Thr Asp Val Pro  Glu Leu Glu Arg Thr  Thr Pro Ile 
    2720                 2725                 2730             


Met Gln  Lys Lys Val Gly Gln  Ile Met Leu Ile Leu  Val Ser Leu 
    2735                 2740                 2745             


Ala Ala  Val Val Val Asn Pro  Ser Val Lys Thr Val  Arg Glu Ala 
    2750                 2755                 2760             


Gly Ile  Leu Ile Thr Ala Ala  Ala Val Thr Leu Trp  Glu Asn Gly 
    2765                 2770                 2775             


Ala Ser  Ser Val Trp Asn Ala  Thr Thr Ala Ile Gly  Leu Cys His 
    2780                 2785                 2790             


Ile Met  Arg Gly Gly Trp Leu  Ser Cys Leu Ser Ile  Thr Trp Thr 
    2795                 2800                 2805             


Leu Ile  Lys Asn Met Glu Lys  Pro Gly Leu Lys Arg  Gly Gly Ala 
    2810                 2815                 2820             


Lys Gly  Arg Thr Leu Gly Glu  Val Trp Lys Glu Arg  Leu Asn Gln 
    2825                 2830                 2835             


Met Thr  Lys Glu Glu Phe Thr  Arg Tyr Arg Lys Glu  Ala Ile Ile 
    2840                 2845                 2850             


Glu Val  Asp Arg Ser Ala Ala  Lys His Ala Arg Lys  Glu Gly Asn 
    2855                 2860                 2865             


Val Thr  Gly Gly His Pro Val  Ser Arg Gly Thr Ala  Lys Leu Arg 
    2870                 2875                 2880             


Trp Leu  Val Glu Arg Arg Phe  Leu Glu Pro Val Gly  Lys Val Ile 
    2885                 2890                 2895             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Cys Tyr Tyr  Met Ala Thr 
    2900                 2905                 2910             


Gln Lys  Arg Val Gln Glu Val  Arg Gly Tyr Thr Lys  Gly Gly Pro 
    2915                 2920                 2925             


Gly His  Glu Glu Pro Gln Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2930                 2935                 2940             


Val Thr  Met Lys Ser Gly Val  Asp Val Phe Tyr Arg  Pro Ser Glu 
    2945                 2950                 2955             


Cys Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2960                 2965                 2970             


Ala Glu  Val Glu Glu His Arg  Thr Ile Arg Val Leu  Glu Met Val 
    2975                 2980                 2985             


Glu Asp  Trp Leu His Arg Gly  Pro Arg Glu Phe Cys  Val Lys Val 
    2990                 2995                 3000             


Leu Cys  Pro Tyr Met Pro Lys  Val Ile Glu Lys Met  Glu Leu Leu 
    3005                 3010                 3015             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Asn Pro  Leu Ser Arg 
    3020                 3025                 3030             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Arg Ala  Ser Gly Asn 
    3035                 3040                 3045             


Val Val  His Ser Val Asn Met  Thr Ser Gln Val Leu  Leu Gly Arg 
    3050                 3055                 3060             


Met Glu  Lys Arg Thr Trp Lys  Gly Pro Gln Tyr Glu  Glu Asp Val 
    3065                 3070                 3075             


Asn Leu  Gly Ser Gly Thr Arg  Ala Val Gly Lys Pro  Leu Leu Asn 
    3080                 3085                 3090             


Ser Asp  Thr Ser Lys Ile Lys  Asn Arg Ile Glu Arg  Leu Arg Arg 
    3095                 3100                 3105             


Glu Tyr  Ser Ser Thr Trp His  His Asp Glu Asn His  Pro Tyr Arg 
    3110                 3115                 3120             


Thr Trp  Asn Tyr His Gly Ser  Tyr Asp Val Lys Pro  Thr Gly Ser 
    3125                 3130                 3135             


Ala Ser  Ser Leu Val Asn Gly  Val Val Arg Leu Leu  Ser Lys Pro 
    3140                 3145                 3150             


Trp Asp  Thr Ile Thr Asn Val  Thr Thr Met Ala Met  Thr Asp Thr 
    3155                 3160                 3165             


Thr Pro  Phe Gly Gln Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr 
    3170                 3175                 3180             


Lys Ala  Pro Glu Pro Pro Glu  Gly Val Lys Tyr Val  Leu Asn Glu 
    3185                 3190                 3195             


Thr Thr  Asn Trp Leu Trp Ala  Phe Leu Ala Arg Glu  Lys Arg Pro 
    3200                 3205                 3210             


Arg Met  Cys Ser Arg Glu Glu  Phe Ile Arg Lys Val  Asn Ser Asn 
    3215                 3220                 3225             


Ala Ala  Leu Gly Ala Met Phe  Glu Glu Gln Asn Gln  Trp Arg Ser 
    3230                 3235                 3240             


Ala Arg  Glu Ala Val Glu Asp  Pro Lys Phe Trp Glu  Met Val Asp 
    3245                 3250                 3255             


Glu Glu  Arg Glu Ala His Leu  Arg Gly Glu Cys His  Thr Cys Ile 
    3260                 3265                 3270             


Tyr Asn  Met Met Gly Lys Arg  Glu Lys Lys Pro Gly  Glu Phe Gly 
    3275                 3280                 3285             


Lys Ala  Lys Gly Ser Arg Ala  Ile Trp Phe Met Trp  Leu Gly Ala 
    3290                 3295                 3300             


Arg Phe  Leu Glu Phe Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His 
    3305                 3310                 3315             


Trp Leu  Gly Arg Lys Asn Ser  Gly Gly Gly Val Glu  Gly Leu Gly 
    3320                 3325                 3330             


Leu Gln  Lys Leu Gly Tyr Ile  Leu Arg Glu Val Gly  Thr Arg Pro 
    3335                 3340                 3345             


Gly Gly  Lys Ile Tyr Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg 
    3350                 3355                 3360             


Ile Thr  Arg Ala Asp Leu Glu  Asn Glu Ala Lys Val  Leu Glu Leu 
    3365                 3370                 3375             


Leu Asp  Gly Glu His Arg Arg  Leu Ala Arg Ala Ile  Ile Glu Leu 
    3380                 3385                 3390             


Thr Tyr  Arg His Lys Val Val  Lys Val Met Arg Pro  Ala Ala Asp 
    3395                 3400                 3405             


Gly Arg  Thr Val Met Asp Val  Ile Ser Arg Glu Asp  Gln Arg Gly 
    3410                 3415                 3420             


Ser Gly  Gln Val Val Thr Tyr  Ala Leu Asn Thr Phe  Thr Asn Leu 
    3425                 3430                 3435             


Ala Val  Gln Leu Val Arg Met  Met Glu Gly Glu Gly  Val Ile Gly 
    3440                 3445                 3450             


Pro Asp  Asp Val Glu Lys Leu  Thr Lys Gly Lys Gly  Pro Lys Val 
    3455                 3460                 3465             


Arg Thr  Trp Leu Phe Glu Asn  Gly Glu Glu Arg Leu  Ser Arg Met 
    3470                 3475                 3480             


Ala Val  Ser Gly Asp Asp Cys  Val Val Lys Pro Leu  Asp Asp Arg 
    3485                 3490                 3495             


Phe Ala  Thr Ser Leu His Phe  Leu Asn Ala Met Ser  Lys Val Arg 
    3500                 3505                 3510             


Lys Asp  Ile Gln Glu Trp Lys  Pro Ser Thr Gly Trp  Tyr Asp Trp 
    3515                 3520                 3525             


Gln Gln  Val Pro Phe Cys Ser  Asn His Phe Thr Glu  Leu Ile Met 
    3530                 3535                 3540             


Lys Asp  Gly Arg Thr Leu Val  Val Pro Cys Arg Gly  Gln Asp Glu 
    3545                 3550                 3555             


Leu Val  Gly Arg Ala Arg Ile  Ser Pro Gly Ala Gly  Trp Asn Val 
    3560                 3565                 3570             


Arg Asp  Thr Ala Cys Leu Ala  Lys Ser Tyr Ala Gln  Met Trp Leu 
    3575                 3580                 3585             


Leu Leu  Tyr Phe His Arg Arg  Asp Leu Arg Leu Met  Ala Asn Ala 
    3590                 3595                 3600             


Ile Cys  Ser Ala Val Pro Val  Asn Trp Val Pro Thr  Gly Arg Thr 
    3605                 3610                 3615             


Thr Trp  Ser Ile His Ala Gly  Gly Glu Trp Met Thr  Thr Glu Asp 
    3620                 3625                 3630             


Met Leu  Glu Val Trp Asn Arg  Val Trp Ile Glu Glu  Asn Glu Trp 
    3635                 3640                 3645             


Met Glu  Asp Lys Thr Pro Val  Glu Lys Trp Ser Asp  Val Pro Tyr 
    3650                 3655                 3660             


Ser Gly  Lys Arg Glu Asp Ile  Trp Cys Gly Ser Leu  Ile Gly Thr 
    3665                 3670                 3675             


Arg Ala  Arg Ala Thr Trp Ala  Glu Asn Ile Gln Val  Ala Ile Asn 
    3680                 3685                 3690             


Gln Val  Arg Ala Ile Ile Gly  Asp Glu Lys Tyr Val  Asp Tyr Met 
    3695                 3700                 3705             


Ser Ser  Leu Lys Arg Tyr Glu  Asp Thr Thr Leu Val  Glu Asp Thr 
    3710                 3715                 3720             


Val Leu  
    3725 


