                         SEQUENCE LISTING

<110>  The National Institutes of Health, as represented by the 
       Secretary, Department of Health and Human Services
       Bonnemann, Carsten G.
       Bolduc, Veronique
       Wilton, Steve
       MacArthur, Daniel
       Lek, Monkol
       Cummings, Beryl
 
<120>  DIAGNOSING COL6-RELATED DISORDERS AND METHODS FOR TREATING SAME

<130>  6137NINDS-2-PCT

<140>  Not yet assigned
<141>  2017-07-05

<150>  62/358,482
<151>  2016-07-05

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  1
ggagaaaaag ggagccgtgg ggagaag                                           27


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Glu Lys Gly Ser Arg Gly Glu Lys 
1               5                   


<210>  3
<211>  479
<212>  DNA
<213>  Homo sapiens

<400>  3
gtgagtgagg ctcgacctcg gagctggtct ctccaggcgc agatgtgcca tcctggacga       60

gggtgtcccc ggggatgagg acagtgtccc tgacaggaga ccacgtgtcc tgcagacccg      120

ctccaccgcc cctcgccgtc ccctccatct ggaaggacaa ggacagccac ccaggcaccc      180

agcaaaggcg cctgtgtcac tttcacccca ccccagagca ggggtccccc gggcggttac      240

cctctgcgga gccgggggtc ccccgggcgg ttaccctctg cggagccggg ggtcccccgg      300

gcggttaccc tctgcagagc ggcccctccc catcactgtc agtccccatg attctcagca      360

gtgatgttgt cccctcgggt tgggggcacc caagcccctg cctcgcgtgg gcctaagcca      420

ggcttgccct gccctcccca ccccaaatac cccctcacac ccgcttcctg tctccgcag       479


<210>  4
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  4
acccgctcca ccgcccctcg ccgtcccctc catctggaag gacaaggaca gccacccagg       60

cacccagcaa ag                                                           72


<210>  5
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  5

Thr Arg Ser Thr Ala Pro Arg Arg Pro Leu His Leu Glu Gly Gln Gly 
1               5                   10                  15      


Gln Pro Pro Arg His Pro Ala Lys 
            20                  


<210>  6
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  6
acccaggcac ccagcaaagg cgcctgtgtc actttcaccc ct                          42


<210>  7
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  7
ggctccaggg gacccaaggg ctacaag                                           27


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Ser Arg Gly Pro Lys Gly Tyr Lys 
1               5                   


<210>  9
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  9
cgtggggaga agacccgctc cacc                                              24


<210>  10
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Gly Glu Lys Thr Arg Ser Thr 
1               5               


<210>  11
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  11
cacccagcaa agggctccag ggga                                              24


<210>  12
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  12

His Pro Ala Lys Gly Ser Arg Gly 
1               5               


<210>  13
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  13
cgtggggaga agggctccag ggga                                              24


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Gly Glu Lys Gly Ser Arg Gly 
1               5               


<210>  15
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15
guggagcggg ucugcaggac acgug                                             25


<210>  16
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16
ggcuguccuu guccucccag augga                                             25


<210>  17
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17
aggcaccuuu gcugggugcc ugggu                                             25


<210>  18
<211>  25
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18
ugaaagugac acaggcaccu uugcu                                             25


<210>  19
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19
ggugaaagug acacaggcaa ccu                                               23


<210>  20
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20
agauggaggg gacggcgagg                                                   20


<210>  21
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21
ggcuguccuu guccuuccag                                                   20


<210>  22
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22
gugccugggu ggcuguccuu                                                   20


<210>  23
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  23
cacguguccu gcagacccgc uccac                                             25


<210>  24
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  24
uccaucugga aggacaagga cagcc                                             25


<210>  25
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  25
acccaggcac ccagcaaagg ugccu                                             25


<210>  26
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  26
agcaaaggug ccugugucac uuuca                                             25


<210>  27
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  27
aggugccugu gucacuuuca cc                                                22


<210>  28
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  28
ccucgccguc cccuccaucu                                                   20


<210>  29
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  29
cuggaaggac aaggacagcc                                                   20


<210>  30
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  30
aaggacagcc acccaggcac                                                   20


<210>  31
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  31
aggacacctg gtctcctgtc aggga                                             25


<210>  32
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  32
gctgtccttg tccttccaga tggag                                             25


<210>  33
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  33
tgaaagtgac acaggcacct ttgct                                             25


<210>  34
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  34
gtggctgtcc ttgtccttcc agatg                                             25


<210>  35
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  35
ttgtccttcc agatggacgg gac                                               23


<210>  36
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  36
gtgcctgggt cgctgtcctt gtcct                                             25


<210>  37
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  37
tctgcaggac acgtggtctc ctgtc                                             25


<210>  38
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  38
ggtctgcagg acacgtggtc tcctg                                             25


<210>  39
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  39
ctgtccttgt ccttccagat ggagg                                             25


<210>  40
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  40
ggctgtcctt gtccttccag atgga                                             25


<210>  41
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  41
tggctgtcct tgtccttcca gatgg                                             25


<210>  42
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  42
ggtggctgtc cttgtccttc cagat                                             25


<210>  43
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  43
tggggtgaaa gtgacacagg cacct                                             25


<210>  44
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  44
ggtgaaagtg acacaggcac ctttg                                             25


<210>  45
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  45
ucccugacag gagaccacgu guccu                                             25


<210>  46
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  46
cuccaucugg aaggacaagg acagc                                             25


<210>  47
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  47
agcaaaggug ccugugucac uuuca                                             25


<210>  48
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  48
caucuggaag gacaaggaca gccac                                             25


<210>  49
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  49
guccccucca ucuggaagga caa                                               23


<210>  50
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  50
aggacaagga cagccaccca ggcac                                             25


<210>  51
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  51
gacaggagac cacguguccu gcaga                                             25


<210>  52
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  52
caggagacca cguguccugc agacc                                             25


<210>  53
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  53
ccuccaucug gaaggacaag gacag                                             25


<210>  54
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  54
uccaucugga aggacaagga cagcc                                             25


<210>  55
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  55
ccaucuggaa ggacaaggac agcca                                             25


<210>  56
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  56
aucuggaagg acaaggacag ccacc                                             25


<210>  57
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  57
aggugccugu gucacuuuca cccca                                             25


<210>  58
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  58
caaaggugcc ugugucacuu ucacc                                             25


<210>  59
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  59
agccgtgggg agaaggtgag tgaggctcga                                        30


<210>  60
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  60
ttcctgtctc cgcagggctc caggggaccc                                        30


<210>  61
<211>  4246
<212>  DNA
<213>  Homo sapiens

<400>  61
gctctcactc tggctgggag cagaaggcag cctcggtctc tgggcggcgg cggcggccca       60

ctctgccctg gccgcgctgt gtggtgaccg caggccccag acatgagggc ggcccgtgct      120

ctgctgcccc tgctgctgca ggcctgctgg acagccgcgc aggatgagcc ggagaccccg      180

agggccgtgg ccttccagga ctgccccgtg gacctgttct ttgtgctgga cacctctgag      240

agcgtggccc tgaggctgaa gccctacggg gccctcgtgg acaaagtcaa gtccttcacc      300

aagcgcttca tcgacaacct gagggacagg tactaccgct gtgaccgaaa cctggtgtgg      360

aacgcaggcg cgctgcacta cagtgacgag gtggagatca tccaaggcct cacgcgcatg      420

cctggcggcc gcgacgcact caaaagcagc gtggacgcgg tcaagtactt tgggaagggc      480

acctacaccg actgcgctat caagaagggg ctggagcagc tcctcgtggg gggctcccac      540

ctgaaggaga ataagtacct gattgtggtg accgacgggc accccctgga gggctacaag      600

gaaccctgtg gggggctgga ggatgctgtg aacgaggcca agcacctggg cgtcaaagtc      660

ttctcggtgg ccatcacacc cgaccacctg gagccgcgtc tgagcatcat cgccacggac      720

cacacgtacc ggcgcaactt cacggcggct gactggggcc agagccgcga cgcagaggag      780

gccatcagcc agaccatcga caccatcgtg gacatgatca aaaataacgt ggagcaagtg      840

tgctgctcct tcgaatgcca gcctgcaaga ggacctccgg ggctccgggg cgaccccggc      900

tttgagggag aacgaggcaa gccggggctc ccaggagaga agggagaagc cggagatcct      960

ggaagacccg gggacctcgg acctgttggg taccagggaa tgaagggaga aaaagggagc     1020

cgtggggaga agggctccag gggacccaag ggctacaagg gagagaaggg caagcgtggc     1080

atcgacgggg tggacggcgt gaagggggag atggggtacc caggcctgcc aggctgcaag     1140

ggctcgcccg ggtttgacgg cattcaagga ccccctggcc ccaagggaga ccccggtgcc     1200

tttggactga aaggagaaaa gggcgagcct ggagctgacg gggaggcggg gagaccaggg     1260

agctcgggac catctggaga cgagggccag ccgggagagc ctgggccccc cggagagaaa     1320

ggagaggcgg gcgacgaggg gaacccagga cctgacggtg cccccgggga gcggggtggc     1380

cctggagaga gaggaccacg ggggacccca ggcacgcggg gaccaagagg agaccctggt     1440

gaagctggcc cgcagggtga tcagggaaga gaaggccccg ttggtgtccc tggagacccg     1500

ggcgaggctg gccctatcgg acctaaaggc taccgaggcg atgagggtcc cccagggtcc     1560

gagggtgcca gaggagcccc aggacctgcc ggaccccctg gagacccggg gctgatgggt     1620

gaaaggggag aagacggccc cgctggaaat ggcaccgagg gcttccccgg cttccccggg     1680

tatccgggca acaggggcgc tcccgggata aacggcacga agggctaccc cggcctcaag     1740

ggggacgagg gagaagccgg ggaccccgga gacgataaca acgacattgc accccgagga     1800

gtcaaaggag caaaggggta ccggggtccc gagggccccc agggaccccc aggacaccaa     1860

ggaccgcctg ggccggacga atgcgagatt ttggacatca tcatgaaaat gtgctcttgc     1920

tgtgaatgca agtgcggccc catcgacctc ctgttcgtgc tggacagctc agagagcatt     1980

ggcctgcaga acttcgagat tgccaaggac ttcgtcgtca aggtcatcga ccggctgagc     2040

cgggacgagc tggtcaagtt cgagccaggg cagtcgtacg cgggtgtggt gcagtacagc     2100

cacagccaga tgcaggagca cgtgagcctg cgcagcccca gcatccggaa cgtgcaggag     2160

ctcaaggaag ccatcaagag cctgcagtgg atggcgggcg gcaccttcac gggggaggcc     2220

ctgcagtaca cgcgggacca gctgctgccg cccagcccga acaaccgcat cgccctggtc     2280

atcactgacg ggcgctcaga cactcagagg gacaccacac cgctcaacgt gctctgcagc     2340

cccggcatcc aggtggtctc cgtgggcatc aaagacgtgt ttgacttcat cccaggctca     2400

gaccagctca atgtcatttc ttgccaaggc ctggcaccat cccagggccg gcccggcctc     2460

tcgctggtca aggagaacta tgcagagctg ctggaggatg ccttcctgaa gaatgtcacc     2520

gcccagatct gcatagacaa gaagtgtcca gattacacct gccccatcac gttctcctcc     2580

ccggctgaca tcaccatcct gctggacggc tccgccagcg tgggcagcca caactttgac     2640

accaccaagc gcttcgccaa gcgcctggcc gagcgcttcc tcacagcggg caggacggac     2700

cccgcccacg acgtgcgggt ggcggtggtg cagtacagcg gcacgggcca gcagcgccca     2760

gagcgggcgt cgctgcagtt cctgcagaac tacacggccc tggccagtgc cgtcgatgcc     2820

atggacttta tcaacgacgc caccgacgtc aacgatgccc tgggctatgt gacccgcttc     2880

taccgcgagg cctcgtccgg cgctgccaag aagaggctgc tgctcttctc agatggcaac     2940

tcgcagggcg ccacgcccgc tgccatcgag aaggccgtgc aggaagccca gcgggcaggc     3000

atcgagatct tcgtggtggt cgtgggccgc caggtgaatg agccccacat ccgcgtcctg     3060

gtcaccggca agacggccga gtacgacgtg gcctacggcg agagccacct gttccgtgtc     3120

cccagctacc aggccctgct ccgcggtgtc ttccaccaga cagtctccag gaaggtggcg     3180

ctgggctagc ccaccctgca cgccggcacc aaaccctgtc ctcccacccc tccccactca     3240

tcactaaaca gagtaaaatg tgatgcgaat tttcccgacc aacctgattc gctagatttt     3300

ttttaaggaa aagcttggaa agccaggaca caacgctgct gcctgctttg tgcagggtcc     3360

tccggggctc agccctgagt tggcatcacc tgcgcagggc cctctggggc tcagccctga     3420

gctagtgtca cctgcacagg gccctctgag gctcagccct gagctggcgt cacctgtgca     3480

gggccctctg gggctcagcc ctgagctggc ctcacctggg ttccccaccc cgggctctcc     3540

tgccctgccc tcctgcccgc cctccctcct gcctgcgcag ctccttccct aggcacctct     3600

gtgctgcatc ccaccagcct gagcaagacg ccctctcggg gcctgtgccg cactagcctc     3660

cctctcctct gtccccatag ctggtttttc ccaccaatcc tcacctaaca gttactttac     3720

aattaaactc aaagcaagct cttctcctca gcttggggca gccattggcc tctgtctcgt     3780

tttgggaaac caaggtcagg aggccgttgc agacataaat ctcggcgact cggccccgtc     3840

tcctgagggt cctgctggtg accggcctgg accttggccc tacagccctg gaggccgctg     3900

ctgaccagca ctgaccccga cctcagagag tactcgcagg ggcgctggct gcactcaaga     3960

ccctcgagat taacggtgct aaccccgtct gctcctccct cccgcagaga ctggggcctg     4020

gactggacat gagagcccct tggtgccaca gagggctgtg tcttactaga aacaacgcaa     4080

acctctcctt cctcagaata gtgatgtgtt cgacgtttta tcaaaggccc cctttctatg     4140

ttcatgttag ttttgctcct tctgtgtttt tttctgaacc atatccatgt tgctgacttt     4200

tccaaataaa ggttttcact cctctaaaaa aaaaaaaaaa aaaaaa                    4246


<210>  62
<211>  1028
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp 
1               5                   10                  15      


Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln 
            20                  25                  30          


Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val 
        35                  40                  45              


Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser 
    50                  55                  60                  


Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys 
65                  70                  75                  80  


Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu 
                85                  90                  95      


Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala 
            100                 105                 110         


Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr 
        115                 120                 125             


Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly 
    130                 135                 140                 


Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val 
                165                 170                 175     


Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr 
            180                 185                 190         


Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr 
        195                 200                 205             


Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala 
    210                 215                 220                 


Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys 
225                 230                 235                 240 


Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg 
                245                 250                 255     


Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly 
            260                 265                 270         


Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg 
        275                 280                 285             


Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys 
    290                 295                 300                 


Gly Ser Arg Gly Glu Lys Gly Ser Arg Gly Pro Lys Gly Tyr Lys Gly 
305                 310                 315                 320 


Glu Lys Gly Lys Arg Gly Ile Asp Gly Val Asp Gly Val Lys Gly Glu 
                325                 330                 335     


Met Gly Tyr Pro Gly Leu Pro Gly Cys Lys Gly Ser Pro Gly Phe Asp 
            340                 345                 350         


Gly Ile Gln Gly Pro Pro Gly Pro Lys Gly Asp Pro Gly Ala Phe Gly 
        355                 360                 365             


Leu Lys Gly Glu Lys Gly Glu Pro Gly Ala Asp Gly Glu Ala Gly Arg 
    370                 375                 380                 


Pro Gly Ser Ser Gly Pro Ser Gly Asp Glu Gly Gln Pro Gly Glu Pro 
385                 390                 395                 400 


Gly Pro Pro Gly Glu Lys Gly Glu Ala Gly Asp Glu Gly Asn Pro Gly 
                405                 410                 415     


Pro Asp Gly Ala Pro Gly Glu Arg Gly Gly Pro Gly Glu Arg Gly Pro 
            420                 425                 430         


Arg Gly Thr Pro Gly Thr Arg Gly Pro Arg Gly Asp Pro Gly Glu Ala 
        435                 440                 445             


Gly Pro Gln Gly Asp Gln Gly Arg Glu Gly Pro Val Gly Val Pro Gly 
    450                 455                 460                 


Asp Pro Gly Glu Ala Gly Pro Ile Gly Pro Lys Gly Tyr Arg Gly Asp 
465                 470                 475                 480 


Glu Gly Pro Pro Gly Ser Glu Gly Ala Arg Gly Ala Pro Gly Pro Ala 
                485                 490                 495     


Gly Pro Pro Gly Asp Pro Gly Leu Met Gly Glu Arg Gly Glu Asp Gly 
            500                 505                 510         


Pro Ala Gly Asn Gly Thr Glu Gly Phe Pro Gly Phe Pro Gly Tyr Pro 
        515                 520                 525             


Gly Asn Arg Gly Ala Pro Gly Ile Asn Gly Thr Lys Gly Tyr Pro Gly 
    530                 535                 540                 


Leu Lys Gly Asp Glu Gly Glu Ala Gly Asp Pro Gly Asp Asp Asn Asn 
545                 550                 555                 560 


Asp Ile Ala Pro Arg Gly Val Lys Gly Ala Lys Gly Tyr Arg Gly Pro 
                565                 570                 575     


Glu Gly Pro Gln Gly Pro Pro Gly His Gln Gly Pro Pro Gly Pro Asp 
            580                 585                 590         


Glu Cys Glu Ile Leu Asp Ile Ile Met Lys Met Cys Ser Cys Cys Glu 
        595                 600                 605             


Cys Lys Cys Gly Pro Ile Asp Leu Leu Phe Val Leu Asp Ser Ser Glu 
    610                 615                 620                 


Ser Ile Gly Leu Gln Asn Phe Glu Ile Ala Lys Asp Phe Val Val Lys 
625                 630                 635                 640 


Val Ile Asp Arg Leu Ser Arg Asp Glu Leu Val Lys Phe Glu Pro Gly 
                645                 650                 655     


Gln Ser Tyr Ala Gly Val Val Gln Tyr Ser His Ser Gln Met Gln Glu 
            660                 665                 670         


His Val Ser Leu Arg Ser Pro Ser Ile Arg Asn Val Gln Glu Leu Lys 
        675                 680                 685             


Glu Ala Ile Lys Ser Leu Gln Trp Met Ala Gly Gly Thr Phe Thr Gly 
    690                 695                 700                 


Glu Ala Leu Gln Tyr Thr Arg Asp Gln Leu Leu Pro Pro Ser Pro Asn 
705                 710                 715                 720 


Asn Arg Ile Ala Leu Val Ile Thr Asp Gly Arg Ser Asp Thr Gln Arg 
                725                 730                 735     


Asp Thr Thr Pro Leu Asn Val Leu Cys Ser Pro Gly Ile Gln Val Val 
            740                 745                 750         


Ser Val Gly Ile Lys Asp Val Phe Asp Phe Ile Pro Gly Ser Asp Gln 
        755                 760                 765             


Leu Asn Val Ile Ser Cys Gln Gly Leu Ala Pro Ser Gln Gly Arg Pro 
    770                 775                 780                 


Gly Leu Ser Leu Val Lys Glu Asn Tyr Ala Glu Leu Leu Glu Asp Ala 
785                 790                 795                 800 


Phe Leu Lys Asn Val Thr Ala Gln Ile Cys Ile Asp Lys Lys Cys Pro 
                805                 810                 815     


Asp Tyr Thr Cys Pro Ile Thr Phe Ser Ser Pro Ala Asp Ile Thr Ile 
            820                 825                 830         


Leu Leu Asp Gly Ser Ala Ser Val Gly Ser His Asn Phe Asp Thr Thr 
        835                 840                 845             


Lys Arg Phe Ala Lys Arg Leu Ala Glu Arg Phe Leu Thr Ala Gly Arg 
    850                 855                 860                 


Thr Asp Pro Ala His Asp Val Arg Val Ala Val Val Gln Tyr Ser Gly 
865                 870                 875                 880 


Thr Gly Gln Gln Arg Pro Glu Arg Ala Ser Leu Gln Phe Leu Gln Asn 
                885                 890                 895     


Tyr Thr Ala Leu Ala Ser Ala Val Asp Ala Met Asp Phe Ile Asn Asp 
            900                 905                 910         


Ala Thr Asp Val Asn Asp Ala Leu Gly Tyr Val Thr Arg Phe Tyr Arg 
        915                 920                 925             


Glu Ala Ser Ser Gly Ala Ala Lys Lys Arg Leu Leu Leu Phe Ser Asp 
    930                 935                 940                 


Gly Asn Ser Gln Gly Ala Thr Pro Ala Ala Ile Glu Lys Ala Val Gln 
945                 950                 955                 960 


Glu Ala Gln Arg Ala Gly Ile Glu Ile Phe Val Val Val Val Gly Arg 
                965                 970                 975     


Gln Val Asn Glu Pro His Ile Arg Val Leu Val Thr Gly Lys Thr Ala 
            980                 985                 990         


Glu Tyr Asp Val Ala Tyr Gly Glu  Ser His Leu Phe Arg  Val Pro Ser 
        995                 1000                 1005             


Tyr Gln  Ala Leu Leu Arg Gly  Val Phe His Gln Thr  Val Ser Arg 
    1010                 1015                 1020             


Lys Val  Ala Leu Gly 
    1025             


<210>  63
<211>  1052
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Arg Ala Ala Arg Ala Leu Leu Pro Leu Leu Leu Gln Ala Cys Trp 
1               5                   10                  15      


Thr Ala Ala Gln Asp Glu Pro Glu Thr Pro Arg Ala Val Ala Phe Gln 
            20                  25                  30          


Asp Cys Pro Val Asp Leu Phe Phe Val Leu Asp Thr Ser Glu Ser Val 
        35                  40                  45              


Ala Leu Arg Leu Lys Pro Tyr Gly Ala Leu Val Asp Lys Val Lys Ser 
    50                  55                  60                  


Phe Thr Lys Arg Phe Ile Asp Asn Leu Arg Asp Arg Tyr Tyr Arg Cys 
65                  70                  75                  80  


Asp Arg Asn Leu Val Trp Asn Ala Gly Ala Leu His Tyr Ser Asp Glu 
                85                  90                  95      


Val Glu Ile Ile Gln Gly Leu Thr Arg Met Pro Gly Gly Arg Asp Ala 
            100                 105                 110         


Leu Lys Ser Ser Val Asp Ala Val Lys Tyr Phe Gly Lys Gly Thr Tyr 
        115                 120                 125             


Thr Asp Cys Ala Ile Lys Lys Gly Leu Glu Gln Leu Leu Val Gly Gly 
    130                 135                 140                 


Ser His Leu Lys Glu Asn Lys Tyr Leu Ile Val Val Thr Asp Gly His 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Lys Glu Pro Cys Gly Gly Leu Glu Asp Ala Val 
                165                 170                 175     


Asn Glu Ala Lys His Leu Gly Val Lys Val Phe Ser Val Ala Ile Thr 
            180                 185                 190         


Pro Asp His Leu Glu Pro Arg Leu Ser Ile Ile Ala Thr Asp His Thr 
        195                 200                 205             


Tyr Arg Arg Asn Phe Thr Ala Ala Asp Trp Gly Gln Ser Arg Asp Ala 
    210                 215                 220                 


Glu Glu Ala Ile Ser Gln Thr Ile Asp Thr Ile Val Asp Met Ile Lys 
225                 230                 235                 240 


Asn Asn Val Glu Gln Val Cys Cys Ser Phe Glu Cys Gln Pro Ala Arg 
                245                 250                 255     


Gly Pro Pro Gly Leu Arg Gly Asp Pro Gly Phe Glu Gly Glu Arg Gly 
            260                 265                 270         


Lys Pro Gly Leu Pro Gly Glu Lys Gly Glu Ala Gly Asp Pro Gly Arg 
        275                 280                 285             


Pro Gly Asp Leu Gly Pro Val Gly Tyr Gln Gly Met Lys Gly Glu Lys 
    290                 295                 300                 


Gly Ser Arg Gly Glu Lys Thr Arg Ser Thr Ala Pro Arg Arg Pro Leu 
305                 310                 315                 320 


His Leu Glu Gly Gln Gly Gln Pro Pro Arg His Pro Ala Lys Gly Ser 
                325                 330                 335     


Arg Gly Pro Lys Gly Tyr Lys Gly Glu Lys Gly Lys Arg Gly Ile Asp 
            340                 345                 350         


Gly Val Asp Gly Val Lys Gly Glu Met Gly Tyr Pro Gly Leu Pro Gly 
        355                 360                 365             


Cys Lys Gly Ser Pro Gly Phe Asp Gly Ile Gln Gly Pro Pro Gly Pro 
    370                 375                 380                 


Lys Gly Asp Pro Gly Ala Phe Gly Leu Lys Gly Glu Lys Gly Glu Pro 
385                 390                 395                 400 


Gly Ala Asp Gly Glu Ala Gly Arg Pro Gly Ser Ser Gly Pro Ser Gly 
                405                 410                 415     


Asp Glu Gly Gln Pro Gly Glu Pro Gly Pro Pro Gly Glu Lys Gly Glu 
            420                 425                 430         


Ala Gly Asp Glu Gly Asn Pro Gly Pro Asp Gly Ala Pro Gly Glu Arg 
        435                 440                 445             


Gly Gly Pro Gly Glu Arg Gly Pro Arg Gly Thr Pro Gly Thr Arg Gly 
    450                 455                 460                 


Pro Arg Gly Asp Pro Gly Glu Ala Gly Pro Gln Gly Asp Gln Gly Arg 
465                 470                 475                 480 


Glu Gly Pro Val Gly Val Pro Gly Asp Pro Gly Glu Ala Gly Pro Ile 
                485                 490                 495     


Gly Pro Lys Gly Tyr Arg Gly Asp Glu Gly Pro Pro Gly Ser Glu Gly 
            500                 505                 510         


Ala Arg Gly Ala Pro Gly Pro Ala Gly Pro Pro Gly Asp Pro Gly Leu 
        515                 520                 525             


Met Gly Glu Arg Gly Glu Asp Gly Pro Ala Gly Asn Gly Thr Glu Gly 
    530                 535                 540                 


Phe Pro Gly Phe Pro Gly Tyr Pro Gly Asn Arg Gly Ala Pro Gly Ile 
545                 550                 555                 560 


Asn Gly Thr Lys Gly Tyr Pro Gly Leu Lys Gly Asp Glu Gly Glu Ala 
                565                 570                 575     


Gly Asp Pro Gly Asp Asp Asn Asn Asp Ile Ala Pro Arg Gly Val Lys 
            580                 585                 590         


Gly Ala Lys Gly Tyr Arg Gly Pro Glu Gly Pro Gln Gly Pro Pro Gly 
        595                 600                 605             


His Gln Gly Pro Pro Gly Pro Asp Glu Cys Glu Ile Leu Asp Ile Ile 
    610                 615                 620                 


Met Lys Met Cys Ser Cys Cys Glu Cys Lys Cys Gly Pro Ile Asp Leu 
625                 630                 635                 640 


Leu Phe Val Leu Asp Ser Ser Glu Ser Ile Gly Leu Gln Asn Phe Glu 
                645                 650                 655     


Ile Ala Lys Asp Phe Val Val Lys Val Ile Asp Arg Leu Ser Arg Asp 
            660                 665                 670         


Glu Leu Val Lys Phe Glu Pro Gly Gln Ser Tyr Ala Gly Val Val Gln 
        675                 680                 685             


Tyr Ser His Ser Gln Met Gln Glu His Val Ser Leu Arg Ser Pro Ser 
    690                 695                 700                 


Ile Arg Asn Val Gln Glu Leu Lys Glu Ala Ile Lys Ser Leu Gln Trp 
705                 710                 715                 720 


Met Ala Gly Gly Thr Phe Thr Gly Glu Ala Leu Gln Tyr Thr Arg Asp 
                725                 730                 735     


Gln Leu Leu Pro Pro Ser Pro Asn Asn Arg Ile Ala Leu Val Ile Thr 
            740                 745                 750         


Asp Gly Arg Ser Asp Thr Gln Arg Asp Thr Thr Pro Leu Asn Val Leu 
        755                 760                 765             


Cys Ser Pro Gly Ile Gln Val Val Ser Val Gly Ile Lys Asp Val Phe 
    770                 775                 780                 


Asp Phe Ile Pro Gly Ser Asp Gln Leu Asn Val Ile Ser Cys Gln Gly 
785                 790                 795                 800 


Leu Ala Pro Ser Gln Gly Arg Pro Gly Leu Ser Leu Val Lys Glu Asn 
                805                 810                 815     


Tyr Ala Glu Leu Leu Glu Asp Ala Phe Leu Lys Asn Val Thr Ala Gln 
            820                 825                 830         


Ile Cys Ile Asp Lys Lys Cys Pro Asp Tyr Thr Cys Pro Ile Thr Phe 
        835                 840                 845             


Ser Ser Pro Ala Asp Ile Thr Ile Leu Leu Asp Gly Ser Ala Ser Val 
    850                 855                 860                 


Gly Ser His Asn Phe Asp Thr Thr Lys Arg Phe Ala Lys Arg Leu Ala 
865                 870                 875                 880 


Glu Arg Phe Leu Thr Ala Gly Arg Thr Asp Pro Ala His Asp Val Arg 
                885                 890                 895     


Val Ala Val Val Gln Tyr Ser Gly Thr Gly Gln Gln Arg Pro Glu Arg 
            900                 905                 910         


Ala Ser Leu Gln Phe Leu Gln Asn Tyr Thr Ala Leu Ala Ser Ala Val 
        915                 920                 925             


Asp Ala Met Asp Phe Ile Asn Asp Ala Thr Asp Val Asn Asp Ala Leu 
    930                 935                 940                 


Gly Tyr Val Thr Arg Phe Tyr Arg Glu Ala Ser Ser Gly Ala Ala Lys 
945                 950                 955                 960 


Lys Arg Leu Leu Leu Phe Ser Asp Gly Asn Ser Gln Gly Ala Thr Pro 
                965                 970                 975     


Ala Ala Ile Glu Lys Ala Val Gln Glu Ala Gln Arg Ala Gly Ile Glu 
            980                 985                 990         


Ile Phe Val Val Val Val Gly Arg  Gln Val Asn Glu Pro  His Ile Arg 
        995                 1000                 1005             


Val Leu  Val Thr Gly Lys Thr  Ala Glu Tyr Asp Val  Ala Tyr Gly 
    1010                 1015                 1020             


Glu Ser  His Leu Phe Arg Val  Pro Ser Tyr Gln Ala  Leu Leu Arg 
    1025                 1030                 1035             


Gly Val  Phe His Gln Thr Val  Ser Arg Lys Val Ala  Leu Gly 
    1040                 1045                 1050         


