                         SEQUENCE LISTING

<110>  Institute for Cancer Research d/b/a The Research Institute 
       of Fox Chase Cancer Center
       Balachandran, Siddharth
       Thapa, Roshan
 
<120>  RNA Virus Vectors Carrying DNA-Dependent Activator Of 
       Interferon-Regulatory Factors (DAI) And Receptor-Interacting 
       Serine/Threonine-Protein Kinase 3 (RIPK3)

<130>  185300.05402WO

<150>  62/359,465
<151>  2016-07-07

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  1297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZBP1 (DAI) cDNA

<400>  1
agagctgcaa gaagcaccag gctcggccac ttcagaagcc ccagcctcga cctagcccac       60

cctctcaggg ccacagtgca gaagcctgca cacctgccaa gtctctccga ctccttgcag      120

ctgctgtcag catggcccag gctcctgctg acccgggcag agaaggccac cttgaacaaa      180

gaatcctgca ggtgctgaca gaggctggct ccccggtgaa acttgcccag ctggtgaagg      240

aatgccaagc acccaagagg gagctcaacc aagtcctcta ccgaatgaaa aaggagttga      300

aagtctccct cacatcccct gccacctggt gcttgggcgg gactgatcct gaaggcgagg      360

gtcctgcaga gctggccttg tccagccctg ccgagaggcc ccagcaacat gcagctacaa      420

ttccagagac ccctggccct cagttcagcc aacaacggga ggaagacatc tacaggtttc      480

tcaaagacaa tggtccccag agggccctgg tcatcgccca agcactggga atgaggacag      540

caaaagatgt gaaccgagac ttgtacagga tgaagagcag gcaccttctg gacatggatg      600

agcagtccaa agcatggacg atttaccgcc cagaagattc tggaagaaga gcaaagtcag      660

cctcaattat ttaccagcac aatccaatca acatgatctg ccagaatgga cccaacagct      720

ggatttccat tgcaaactcc gaagccatcc agattggaca cgggaacatc attacaagac      780

agacagtctc cagggaggac ggttccgccg gtccacgcca cctcccttca atggcaccag      840

gtgattcctc aacttggggg accctagttg atccctgggg gccccaggac atccacatgg      900

agcagtccat actgagacgg gtgcagctgg gacacagcaa tgagatgagg ctccacggcg      960

tcccgtccga gggccctgcc cacatccccc ctggcagccc cccagtgttc cagtgcagtg     1020

ggaagcaggc agcagaggag agaggagctg aatcccagag gaagacactg acgtccagat     1080

cagccgggcg ggatcagtgg ggcagaccca ctgcgggatc agtggagcag aaagacgctt     1140

cccagacagc acaacagcac gagcggagtc tctgccactg ctgccggccc agaagcttcg     1200

tttgaagcaa gaattcccag tccaggaact caccctgagg gggaagccgc ccagagaatc     1260

cacatgaaat cgtgctttct cgaggacgcc accatcg                              1297


<210>  2
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RIPK3 cDNA

<400>  2
atgtcgtgcg tcaagttatg gcccagcggt gcccccgccc ccttggtgtc catcgaggaa       60

ctggagaacc aggagctcgt cggcaaaggc gggttcggca cagtgttccg ggcgcaacat      120

aggaagtggg gctacgatgt ggcggtcaag atcgtaaact caaaggcgat atccagggag      180

gtcaaggcca tggcaagtct ggataacgaa ttcgtgctgc gcctagaagg ggttatcgag      240

aaggtgaact gggaccaaga tcccaagccg gctctggtga ctaaattcat ggagaacggc      300

tccttgtcgg ggctgctgca gtcccagtgc cctcggccct ggccgctcct ttgccgcctg      360

ctgaaagaag tggtgcttgg gatgttttac ctgcacgacc agaacccggt gctcctgcac      420

cgggacctca agccatccaa cgtcctgctg gacccagagc tgcacgtcaa gctggcagat      480

tttggcctgt ccacatttca gggaggctca cagtcaggga cagggtccgg ggagccaggg      540

ggcaccctgg gctacttggc cccagaactg tttgttaacg taaaccggaa ggcctccaca      600

gccagtgacg tctacagctt cgggatccta atgtgggcag tgcttgctgg aagagaagtt      660

gagttgccaa ccgaaccatc actcgtgtac gaagcagtgt gcaacaggca gaaccggcct      720

tcattggctg agctgcccca agccgggcct gagactcccg gcttagaagg actgaaggag      780

ctaatgcagc tctgctggag cagtgagccc aaggacagac cctccttcca ggaatgccta      840

ccaaaaactg atgaagtctt ccagatggtg gagaacaata tgaatgctgc tgtctccacg      900

gtaaaggatt tcctgtctca gctcaggagc agcaatagga gattttctat cccagagtca      960

ggccaaggag ggacagaaat ggatggcttt aggagaacca tagaaaacca gcactctcgt     1020

aatgatgtca tggtttctga gtggctaaac aaactgaatc tagaggagcc tcccagctct     1080

gttcctaaaa aatgcccgag ccttaccaag aggagcaggg cacaagagga gcaggttcca     1140

caagcctgga cagcaggcac atcttcagat tcgatggccc aacctcccca gactccagag     1200

acctcaactt tcagaaacca gatgcccagc cctacctcaa ctggaacacc aagtcctgga     1260

ccccgaggga atcagggggc tgagagacaa ggcatgaact ggtcctgcag gaccccggag     1320

ccaaatccag taacagggcg accgctcgtt aacatataca actgctctgg ggtgcaagtt     1380

ggagacaaca actacttgac tatgcaacag acaactgcct tgcccacatg gggcttggca     1440

ccttcgggca aggggagggg cttgcagcac cccccaccag taggttcgca agaaggccct     1500

aaagatcctg aagcctggag caggccacag ggttggtata atcatagcgg gaaataa        1557


<210>  3
<211>  1682
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MLKL cDNA

<400>  3
atccagcaca gagaagcaaa caccagaagc ttctctccaa ctttcagttt ttctctaaac       60

ttccagtcct tctcatactg tgtcctggtt ataatagttg ctgggacctt attctattct      120

gaatccccag cccctaaaga aggcttggta ctgacgtgta cagcgtagtt acccagtgac      180

tttggggaag gcaggaagag tgtggaaagg acaggaggaa ggaagggagg ggccgtggct      240

ccgagctgcc tagaaagcgg ctccagggag ccagggcacc gtgagcctgg tggttggcag      300

ctggagccac gtcggagggg gaagtgtcgc agcattctct gcaggcatca cagacctgag      360

gcagtggcct ccggagggca ctggacagaa acagccatcc aagtggctga gtggagggac      420

cctgctcaag tgcagctgca gtggccgggg tttccctcag gtagggatcg gggcgccttg      480

tcgccgccag ccacgtgtgg cgtccggtac agtcagcaga gtgcagggtg cgggcaccag      540

gaaagggggc gcaggggaac tcccgcgggc ctcgcgtttg caaacttctc gcctgggcag      600

gaggcggtcg tgggaaagaa ggtggaagag cgagcttttt ggaactgtgc acgggacaga      660

ttggacgcac acccctcggg aggcgcgaag gcatggaaaa tttgaagcat attatcaccc      720

ttggccaggt catccacaaa cggtgtgaag agatgaaata ctgcaagaaa cagtgccggc      780

gcctgggcca ccgcgtcctc ggcctgatca agcctctgga gatgctccag gaccaaggaa      840

agaggagcgt gccctctgag aagttaacca cagccatgaa ccgcttcaag gctgccctgg      900

aggaggctaa tggggagata gaaaagttca gcaatagatc caatatctgc aggtttctaa      960

cagcaagcca ggacaaaata ctcttcaagg acgtgaacag gaagctgagt gatgtctgga     1020

aggagctctc gctgttactt caggttgagc aacgcatgcc tgtttcaccc ataagccaag     1080

gagcgtcctg ggcacaggaa gatcagcagg atgcagacga agacaggcga gctttccaga     1140

tgctaagaag agataatgaa aaaatagaag cttcactgag acgattagaa atcaacatga     1200

aagaaatcaa ggaaactttg aggcagtatt taccaccaaa atgcatgcag gagatcccgc     1260

aagagcaaat caaggagatc aagaaggagc agctttcagg atccccgtgg attctgctaa     1320

gggaaaatga agtcagcaca ctttataaag gagaatacca cagagctcca gtggccataa     1380

aagtattcaa aaaactccag gctggcagca ttgcaatagt gaggcagact ttcaataagg     1440

agatcaaaac catgaagaaa ttcgaatctc ccaacatcct gcgtatattt gggatttgca     1500

ttgatgaaac aggctacacc attcagaagc acctgaactc cacggaaaaa tcagaagctc     1560

aaacttcctg gtaactcaag gctaccaagt gaagatttgg gtacctggct gagtttgggg     1620

ctggcagcct tcagcacacc aatggtgtca atggcaggtg tgcatgggac aagaacatat     1680

gc                                                                    1682


<210>  4
<211>  1295
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ZBP1 (DAI) RNA

<400>  4
agagcugcaa gaagcaccag gcucggccac uucagaagcc ccagccucga ccuagcccac       60

ccucucaggg ccacagugca gaagccugca caccugccaa gucucuccga cuccuugcag      120

cugcugucag cauggcccag gcuccugcug cccgggcaga gaaggccacc uugaacaaag      180

aauccugcag gugcugacag aggcuggcuc cccggugaaa cuugcccagu ggugaaggaa      240

ugccaagcac ccaagaggga gcucaaccaa guccucuacc gaaugaaaaa ggaguugaaa      300

gucucccuca cauccccugc caccuggugc uugggcggga cugauccuga aggcgagggu      360

ccugcagagc uggccuuguc cagcccugcc gagaggcccc agcaacaugc agcuacaauu      420

ccagagaccc cuggcccuca guucagccaa caacgggagg aagacaucua cagguuucuc      480

aaagacaaug guccccagag ggcccugguc aucgcccaag cacugggaau gaggacagca      540

aaagauguga accgagacuu guacaggaug aagagcaggc accuucugga cauggaugag      600

caguccaaag cauggacgau uuaccgccca gaagauucug gaagaagagc aaagucagcc      660

ucaauuauuu accagcacaa uccaaucaac augaucugcc agaauggacc caacagcugg      720

auuuccauug caaacuccga agccauccag auuggacacg ggaacaucau uacaagacag      780

acagucucca gggaggacgg uuccgccggu ccacgccacc ucccuucaau ggcaccaggu      840

gauuccucaa cuugggggac ccuaguugau cccugggggc cccaggacau ccacauggag      900

caguccauac ugagacgggu gcagcuggga cacagcaaug agaugaggcu ccacggcguc      960

ccguccgagg gcccugccca cauccccccu ggcagccccc caguguucca gugcaguggg     1020

aagcaggcag cagaggagag aggagcugaa ucccagagga agacacugac guccagauca     1080

gccgggcggg aucagugggg cagacccacu gcgggaucag uggagcagaa agacgcuucc     1140

cagacagcac aacagcacga gcggagucuc ugccacugcu gccggcccag aagcuucguu     1200

ugaagcaaga auucccaguc caggaacuca cccugagggg gaagccgccc agagaaucca     1260

caugaaaucg ugcuuucucg aggacgccac caucg                                1295


<210>  5
<211>  1557
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RIPK3 RNA

<400>  5
augucgugcg ucaaguuaug gcccagcggu gcccccgccc ccuugguguc caucgaggaa       60

cuggagaacc aggagcucgu cggcaaaggc ggguucggca caguguuccg ggcgcaacau      120

aggaaguggg gcuacgaugu ggcggucaag aucguaaacu caaaggcgau auccagggag      180

gucaaggcca uggcaagucu ggauaacgaa uucgugcugc gccuagaagg gguuaucgag      240

aaggugaacu gggaccaaga ucccaagccg gcucugguga cuaaauucau ggagaacggc      300

uccuugucgg ggcugcugca gucccagugc ccucggcccu ggccgcuccu uugccgccug      360

cugaaagaag uggugcuugg gauguuuuac cugcacgacc agaacccggu gcuccugcac      420

cgggaccuca agccauccaa cguccugcug gacccagagc ugcacgucaa gcuggcagau      480

uuuggccugu ccacauuuca gggaggcuca cagucaggga caggguccgg ggagccaggg      540

ggcacccugg gcuacuuggc cccagaacug uuuguuaacg uaaaccggaa ggccuccaca      600

gccagugacg ucuacagcuu cgggauccua augugggcag ugcuugcugg aagagaaguu      660

gaguugccaa ccgaaccauc acucguguac gaagcagugu gcaacaggca gaaccggccu      720

ucauuggcug agcugcccca agccgggccu gagacucccg gcuuagaagg acugaaggag      780

cuaaugcagc ucugcuggag cagugagccc aaggacagac ccuccuucca ggaaugccua      840

ccaaaaacug augaagucuu ccagauggug gagaacaaua ugaaugcugc ugucuccacg      900

guaaaggauu uccugucuca gcucaggagc agcaauagga gauuuucuau cccagaguca      960

ggccaaggag ggacagaaau ggauggcuuu aggagaacca uagaaaacca gcacucucgu     1020

aaugauguca ugguuucuga guggcuaaac aaacugaauc uagaggagcc ucccagcucu     1080

guuccuaaaa aaugcccgag ccuuaccaag aggagcaggg cacaagagga gcagguucca     1140

caagccugga cagcaggcac aucuucagau ucgauggccc aaccucccca gacuccagag     1200

accucaacuu ucagaaacca gaugcccagc ccuaccucaa cuggaacacc aaguccugga     1260

ccccgaggga aucagggggc ugagagacaa ggcaugaacu gguccugcag gaccccggag     1320

ccaaauccag uaacagggcg accgcucguu aacauauaca acugcucugg ggugcaaguu     1380

ggagacaaca acuacuugac uaugcaacag acaacugccu ugcccacaug gggcuuggca     1440

ccuucgggca aggggagggg cuugcagcac cccccaccag uagguucgca agaaggcccu     1500

aaagauccug aagccuggag caggccacag gguugguaua aucauagcgg gaaauaa        1557


<210>  6
<211>  1682
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MLKL RNA

<400>  6
auccagcaca gagaagcaaa caccagaagc uucucuccaa cuuucaguuu uucucuaaac       60

uuccaguccu ucucauacug uguccugguu auaauaguug cugggaccuu auucuauucu      120

gaauccccag ccccuaaaga aggcuuggua cugacgugua cagcguaguu acccagugac      180

uuuggggaag gcaggaagag uguggaaagg acaggaggaa ggaagggagg ggccguggcu      240

ccgagcugcc uagaaagcgg cuccagggag ccagggcacc gugagccugg ugguuggcag      300

cuggagccac gucggagggg gaagugucgc agcauucucu gcaggcauca cagaccugag      360

gcaguggccu ccggagggca cuggacagaa acagccaucc aaguggcuga guggagggac      420

ccugcucaag ugcagcugca guggccgggg uuucccucag guagggaucg gggcgccuug      480

ucgccgccag ccacgugugg cguccgguac agucagcaga gugcagggug cgggcaccag      540

gaaagggggc gcaggggaac ucccgcgggc cucgcguuug caaacuucuc gccugggcag      600

gaggcggucg ugggaaagaa gguggaagag cgagcuuuuu ggaacugugc acgggacaga      660

uuggacgcac accccucggg aggcgcgaag gcauggaaaa uuugaagcau auuaucaccc      720

uuggccaggu cauccacaaa cggugugaag agaugaaaua cugcaagaaa cagugccggc      780

gccugggcca ccgcguccuc ggccugauca agccucugga gaugcuccag gaccaaggaa      840

agaggagcgu gcccucugag aaguuaacca cagccaugaa ccgcuucaag gcugcccugg      900

aggaggcuaa uggggagaua gaaaaguuca gcaauagauc caauaucugc agguuucuaa      960

cagcaagcca ggacaaaaua cucuucaagg acgugaacag gaagcugagu gaugucugga     1020

aggagcucuc gcuguuacuu cagguugagc aacgcaugcc uguuucaccc auaagccaag     1080

gagcguccug ggcacaggaa gaucagcagg augcagacga agacaggcga gcuuuccaga     1140

ugcuaagaag agauaaugaa aaaauagaag cuucacugag acgauuagaa aucaacauga     1200

aagaaaucaa ggaaacuuug aggcaguauu uaccaccaaa augcaugcag gagaucccgc     1260

aagagcaaau caaggagauc aagaaggagc agcuuucagg auccccgugg auucugcuaa     1320

gggaaaauga agucagcaca cuuuauaaag gagaauacca cagagcucca guggccauaa     1380

aaguauucaa aaaacuccag gcuggcagca uugcaauagu gaggcagacu uucaauaagg     1440

agaucaaaac caugaagaaa uucgaaucuc ccaacauccu gcguauauuu gggauuugca     1500

uugaugaaac aggcuacacc auucagaagc accugaacuc cacggaaaaa ucagaagcuc     1560

aaacuuccug guaacucaag gcuaccaagu gaagauuugg guaccuggcu gaguuugggg     1620

cuggcagccu ucagcacacc aaugguguca auggcaggug ugcaugggac aagaacauau     1680

gc                                                                    1682


<210>  7
<211>  1297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ZBP1 cDNA complement (DAI)

<400>  7
tctcgacgtt cttcgtggtc cgagccggtg aagtcttcgg ggtcggagct ggatcgggtg       60

ggagagtccc ggtgtcacgt cttcggacgt gtggacggtt cagagaggct gaggaacgtc      120

gacgacagtc gtaccgggtc cgaggacgac tgggcccgtc tcttccggtg gaacttgttt      180

cttaggacgt ccacgactgt ctccgaccga ggggccactt tgaacgggtc gaccacttcc      240

ttacggttcg tgggttctcc ctcgagttgg ttcaggagat ggcttacttt ttcctcaact      300

ttcagaggga gtgtagggga cggtggacca cgaacccgcc ctgactagga cttccgctcc      360

caggacgtct cgaccggaac aggtcgggac ggctctccgg ggtcgttgta cgtcgatgtt      420

aaggtctctg gggaccggga gtcaagtcgg ttgttgccct ccttctgtag atgtccaaag      480

agtttctgtt accaggggtc tcccgggacc agtagcgggt tcgtgaccct tactcctgtc      540

gttttctaca cttggctctg aacatgtcct acttctcgtc cgtggaagac ctgtacctac      600

tcgtcaggtt tcgtacctgc taaatggcgg gtcttctaag accttcttct cgtttcagtc      660

ggagttaata aatggtcgtg ttaggttagt tgtactagac ggtcttacct gggttgtcga      720

cctaaaggta acgtttgagg cttcggtagg tctaacctgt gcccttgtag taatgttctg      780

tctgtcagag gtccctcctg ccaaggcggc caggtgcggt ggagggaagt taccgtggtc      840

cactaaggag ttgaaccccc tgggatcaac tagggacccc cggggtcctg taggtgtacc      900

tcgtcaggta tgactctgcc cacgtcgacc ctgtgtcgtt actctactcc gaggtgccgc      960

agggcaggct cccgggacgg gtgtaggggg gaccgtcggg gggtcacaag gtcacgtcac     1020

ccttcgtccg tcgtctcctc tctcctcgac ttagggtctc cttctgtgac tgcaggtcta     1080

gtcggcccgc cctagtcacc ccgtctgggt gacgccctag tcacctcgtc tttctgcgaa     1140

gggtctgtcg tgttgtcgtg ctcgcctcag agacggtgac gacggccggg tcttcgaagc     1200

aaacttcgtt cttaagggtc aggtccttga gtgggactcc cccttcggcg ggtctcttag     1260

gtgtacttta gcacgaaaga gctcctgcgg tggtagc                              1297


<210>  8
<211>  1557
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RIPK3 cDNA complement

<400>  8
tacagcacgc agttcaatac cgggtcgcca cgggggcggg ggaaccacag gtagctcctt       60

gacctcttgg tcctcgagca gccgtttccg cccaagccgt gtcacaaggc ccgcgttgta      120

tccttcaccc cgatgctaca ccgccagttc tagcatttga gtttccgcta taggtccctc      180

cagttccggt accgttcaga cctattgctt aagcacgacg cggatcttcc ccaatagctc      240

ttccacttga ccctggttct agggttcggc cgagaccact gatttaagta cctcttgccg      300

aggaacagcc ccgacgacgt cagggtcacg ggagccggga ccggcgagga aacggcggac      360

gactttcttc accacgaacc ctacaaaatg gacgtgctgg tcttgggcca cgaggacgtg      420

gccctggagt tcggtaggtt gcaggacgac ctgggtctcg acgtgcagtt cgaccgtcta      480

aaaccggaca ggtgtaaagt ccctccgagt gtcagtccct gtcccaggcc cctcggtccc      540

ccgtgggacc cgatgaaccg gggtcttgac aaacaattgc atttggcctt ccggaggtgt      600

cggtcactgc agatgtcgaa gccctaggat tacacccgtc acgaacgacc ttctcttcaa      660

ctcaacggtt ggcttggtag tgagcacatg cttcgtcaca cgttgtccgt cttggccgga      720

agtaaccgac tcgacggggt tcggcccgga ctctgagggc cgaatcttcc tgacttcctc      780

gattacgtcg agacgacctc gtcactcggg ttcctgtctg ggaggaaggt ccttacggat      840

ggtttttgac tacttcagaa ggtctaccac ctcttgttat acttacgacg acagaggtgc      900

catttcctaa aggacagagt cgagtcctcg tcgttatcct ctaaaagata gggtctcagt      960

ccggttcctc cctgtcttta cctaccgaaa tcctcttggt atcttttggt cgtgagagca     1020

ttactacagt accaaagact caccgatttg tttgacttag atctcctcgg agggtcgaga     1080

caaggatttt ttacgggctc ggaatggttc tcctcgtccc gtgttctcct cgtccaaggt     1140

gttcggacct gtcgtccgtg tagaagtcta agctaccggg ttggaggggt ctgaggtctc     1200

tggagttgaa agtctttggt ctacgggtcg ggatggagtt gaccttgtgg ttcaggacct     1260

ggggctccct tagtcccccg actctctgtt ccgtacttga ccaggacgtc ctggggcctc     1320

ggtttaggtc attgtcccgc tggcgagcaa ttgtatatgt tgacgagacc ccacgttcaa     1380

cctctgttgt tgatgaactg atacgttgtc tgttgacgga acgggtgtac cccgaaccgt     1440

ggaagcccgt tcccctcccc gaacgtcgtg gggggtggtc atccaagcgt tcttccggga     1500

tttctaggac ttcggacctc gtccggtgtc ccaaccatat tagtatcgcc ctttatt        1557


<210>  9
<211>  1682
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MLKL cDNA complement

<400>  9
taggtcgtgt ctcttcgttt gtggtcttcg aagagaggtt gaaagtcaaa aagagatttg       60

aaggtcagga agagtatgac acaggaccaa tattatcaac gaccctggaa taagataaga      120

cttaggggtc ggggatttct tccgaaccat gactgcacat gtcgcatcaa tgggtcactg      180

aaaccccttc cgtccttctc acacctttcc tgtcctcctt ccttccctcc ccggcaccga      240

ggctcgacgg atctttcgcc gaggtccctc ggtcccgtgg cactcggacc accaaccgtc      300

gacctcggtg cagcctcccc cttcacagcg tcgtaagaga cgtccgtagt gtctggactc      360

cgtcaccgga ggcctcccgt gacctgtctt tgtcggtagg ttcaccgact cacctccctg      420

ggacgagttc acgtcgacgt caccggcccc aaagggagtc catccctagc cccgcggaac      480

agcggcggtc ggtgcacacc gcaggccatg tcagtcgtct cacgtcccac gcccgtggtc      540

ctttcccccg cgtccccttg agggcgcccg gagcgcaaac gtttgaagag cggacccgtc      600

ctccgccagc accctttctt ccaccttctc gctcgaaaaa ccttgacacg tgccctgtct      660

aacctgcgtg tggggagccc tccgcgcttc cgtacctttt aaacttcgta taatagtggg      720

aaccggtcca gtaggtgttt gccacacttc tctactttat gacgttcttt gtcacggccg      780

cggacccggt ggcgcaggag ccggactagt tcggagacct ctacgaggtc ctggttcctt      840

tctcctcgca cgggagactc ttcaattggt gtcggtactt ggcgaagttc cgacgggacc      900

tcctccgatt acccctctat cttttcaagt cgttatctag gttatagacg tccaaagatt      960

gtcgttcggt cctgttttat gagaagttcc tgcacttgtc cttcgactca ctacagacct     1020

tcctcgagag cgacaatgaa gtccaactcg ttgcgtacgg acaaagtggg tattcggttc     1080

ctcgcaggac ccgtgtcctt ctagtcgtcc tacgtctgct tctgtccgct cgaaaggtct     1140

acgattcttc tctattactt ttttatcttc gaagtgactc tgctaatctt tagttgtact     1200

ttctttagtt cctttgaaac tccgtcataa atggtggttt tacgtacgtc ctctagggcg     1260

ttctcgttta gttcctctag ttcttcctcg tcgaaagtcc taggggcacc taagacgatt     1320

cccttttact tcagtcgtgt gaaatatttc ctcttatggt gtctcgaggt caccggtatt     1380

ttcataagtt ttttgaggtc cgaccgtcgt aacgttatca ctccgtctga aagttattcc     1440

tctagttttg gtacttcttt aagcttagag ggttgtagga cgcatataaa ccctaaacgt     1500

aactactttg tccgatgtgg taagtcttcg tggacttgag gtgccttttt agtcttcgag     1560

tttgaaggac cattgagttc cgatggttca cttctaaacc catggaccga ctcaaacccc     1620

gaccgtcgga agtcgtgtgg ttaccacagt taccgtccac acgtaccctg ttcttgtata     1680

cg                                                                    1682


<210>  10
<211>  1297
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ZBP1 (DAI) RNA complement

<400>  10
ucucgacguu cuucgugguc cgagccggug aagucuucgg ggucggagcu ggaucgggug       60

ggagaguccc ggugucacgu cuucggacgu guggacgguu cagagaggcu gaggaacguc      120

gacgacaguc guaccggguc cgaggacgac ugggcccguc ucuuccggug gaacuuguuu      180

cuuaggacgu ccacgacugu cuccgaccga ggggccacuu ugaacggguc gaccacuucc      240

uuacgguucg uggguucucc cucgaguugg uucaggagau ggcuuacuuu uuccucaacu      300

uucagaggga guguagggga cgguggacca cgaacccgcc cugacuagga cuuccgcucc      360

caggacgucu cgaccggaac aggucgggac ggcucuccgg ggucguugua cgucgauguu      420

aaggucucug gggaccggga gucaagucgg uuguugcccu ccuucuguag auguccaaag      480

aguuucuguu accagggguc ucccgggacc aguagcgggu ucgugacccu uacuccuguc      540

guuuucuaca cuuggcucug aacauguccu acuucucguc cguggaagac cuguaccuac      600

ucgucagguu ucguaccugc uaaauggcgg gucuucuaag accuucuucu cguuucaguc      660

ggaguuaaua aauggucgug uuagguuagu uguacuagac ggucuuaccu ggguugucga      720

ccuaaaggua acguuugagg cuucgguagg ucuaaccugu gcccuuguag uaauguucug      780

ucugucagag gucccuccug ccaaggcggc caggugcggu ggagggaagu uaccgugguc      840

cacuaaggag uugaaccccc ugggaucaac uagggacccc cgggguccug uagguguacc      900

ucgucaggua ugacucugcc cacgucgacc cugugucguu acucuacucc gaggugccgc      960

agggcaggcu cccgggacgg guguaggggg gaccgucggg gggucacaag gucacgucac     1020

ccuucguccg ucgucuccuc ucuccucgac uuagggucuc cuucugugac ugcaggucua     1080

gucggcccgc ccuagucacc ccgucugggu gacgcccuag ucaccucguc uuucugcgaa     1140

gggucugucg uguugucgug cucgccucag agacggugac gacggccggg ucuucgaagc     1200

aaacuucguu cuuaaggguc agguccuuga gugggacucc cccuucggcg ggucucuuag     1260

guguacuuua gcacgaaaga gcuccugcgg ugguagc                              1297


<210>  11
<211>  1557
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RIPK3 RNA complement

<400>  11
uacagcacgc aguucaauac cgggucgcca cgggggcggg ggaaccacag guagcuccuu       60

gaccucuugg uccucgagca gccguuuccg cccaagccgu gucacaaggc ccgcguugua      120

uccuucaccc cgaugcuaca ccgccaguuc uagcauuuga guuuccgcua uaggucccuc      180

caguuccggu accguucaga ccuauugcuu aagcacgacg cggaucuucc ccaauagcuc      240

uuccacuuga cccugguucu aggguucggc cgagaccacu gauuuaagua ccucuugccg      300

aggaacagcc ccgacgacgu cagggucacg ggagccggga ccggcgagga aacggcggac      360

gacuuucuuc accacgaacc cuacaaaaug gacgugcugg ucuugggcca cgaggacgug      420

gcccuggagu ucgguagguu gcaggacgac cugggucucg acgugcaguu cgaccgucua      480

aaaccggaca gguguaaagu cccuccgagu gucagucccu gucccaggcc ccucgguccc      540

ccgugggacc cgaugaaccg gggucuugac aaacaauugc auuuggccuu ccggaggugu      600

cggucacugc agaugucgaa gcccuaggau uacacccguc acgaacgacc uucucuucaa      660

cucaacgguu ggcuugguag ugagcacaug cuucgucaca cguuguccgu cuuggccgga      720

aguaaccgac ucgacggggu ucggcccgga cucugagggc cgaaucuucc ugacuuccuc      780

gauuacgucg agacgaccuc gucacucggg uuccugucug ggaggaaggu ccuuacggau      840

gguuuuugac uacuucagaa ggucuaccac cucuuguuau acuuacgacg acagaggugc      900

cauuuccuaa aggacagagu cgaguccucg ucguuauccu cuaaaagaua gggucucagu      960

ccgguuccuc ccugucuuua ccuaccgaaa uccucuuggu aucuuuuggu cgugagagca     1020

uuacuacagu accaaagacu caccgauuug uuugacuuag aucuccucgg agggucgaga     1080

caaggauuuu uuacgggcuc ggaaugguuc uccucguccc guguucuccu cguccaaggu     1140

guucggaccu gucguccgug uagaagucua agcuaccggg uuggaggggu cugaggucuc     1200

uggaguugaa agucuuuggu cuacgggucg ggauggaguu gaccuugugg uucaggaccu     1260

ggggcucccu uagucccccg acucucuguu ccguacuuga ccaggacguc cuggggccuc     1320

gguuuagguc auugucccgc uggcgagcaa uuguauaugu ugacgagacc ccacguucaa     1380

ccucuguugu ugaugaacug auacguuguc uguugacgga acggguguac cccgaaccgu     1440

ggaagcccgu uccccucccc gaacgucgug gggggugguc auccaagcgu ucuuccggga     1500

uuucuaggac uucggaccuc guccgguguc ccaaccauau uaguaucgcc cuuuauu        1557


<210>  12
<211>  1682
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MLKL RNA complement

<400>  12
uaggucgugu cucuucguuu guggucuucg aagagagguu gaaagucaaa aagagauuug       60

aaggucagga agaguaugac acaggaccaa uauuaucaac gacccuggaa uaagauaaga      120

cuuagggguc ggggauuucu uccgaaccau gacugcacau gucgcaucaa ugggucacug      180

aaaccccuuc cguccuucuc acaccuuucc uguccuccuu ccuucccucc ccggcaccga      240

ggcucgacgg aucuuucgcc gaggucccuc ggucccgugg cacucggacc accaaccguc      300

gaccucggug cagccucccc cuucacagcg ucguaagaga cguccguagu gucuggacuc      360

cgucaccgga ggccucccgu gaccugucuu ugucgguagg uucaccgacu caccucccug      420

ggacgaguuc acgucgacgu caccggcccc aaagggaguc caucccuagc cccgcggaac      480

agcggcgguc ggugcacacc gcaggccaug ucagucgucu cacgucccac gcccgugguc      540

cuuucccccg cguccccuug agggcgcccg gagcgcaaac guuugaagag cggacccguc      600

cuccgccagc acccuuucuu ccaccuucuc gcucgaaaaa ccuugacacg ugcccugucu      660

aaccugcgug uggggagccc uccgcgcuuc cguaccuuuu aaacuucgua uaauaguggg      720

aaccggucca guagguguuu gccacacuuc ucuacuuuau gacguucuuu gucacggccg      780

cggacccggu ggcgcaggag ccggacuagu ucggagaccu cuacgagguc cugguuccuu      840

ucuccucgca cgggagacuc uucaauuggu gucgguacuu ggcgaaguuc cgacgggacc      900

uccuccgauu accccucuau cuuuucaagu cguuaucuag guuauagacg uccaaagauu      960

gucguucggu ccuguuuuau gagaaguucc ugcacuuguc cuucgacuca cuacagaccu     1020

uccucgagag cgacaaugaa guccaacucg uugcguacgg acaaaguggg uauucgguuc     1080

cucgcaggac ccguguccuu cuagucgucc uacgucugcu ucuguccgcu cgaaaggucu     1140

acgauucuuc ucuauuacuu uuuuaucuuc gaagugacuc ugcuaaucuu uaguuguacu     1200

uucuuuaguu ccuuugaaac uccgucauaa auggugguuu uacguacguc cucuagggcg     1260

uucucguuua guuccucuag uucuuccucg ucgaaagucc uaggggcacc uaagacgauu     1320

cccuuuuacu ucagucgugu gaaauauuuc cucuuauggu gucucgaggu caccgguauu     1380

uucauaaguu uuuugagguc cgaccgucgu aacguuauca cuccgucuga aaguuauucc     1440

ucuaguuuug guacuucuuu aagcuuagag gguuguagga cgcauauaaa cccuaaacgu     1500

aacuacuuug uccgaugugg uaagucuucg uggacuugag gugccuuuuu agucuucgag     1560

uuugaaggac cauugaguuc cgaugguuca cuucuaaacc cauggaccga cucaaacccc     1620

gaccgucgga agucgugugg uuaccacagu uaccguccac acguacccug uucuuguaua     1680

cg                                                                    1682


<210>  13
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZBP1 (DAI) Protein

<400>  13

Met Ala Gln Ala Pro Ala Asp Pro Gly Arg Glu Gly His Leu Glu Gln 
1               5                   10                  15      

Arg Ile Leu Gln Val Leu Thr Glu Ala Gly Ser Pro Val Lys Leu Ala 
            20                  25                  30          

Gln Leu Val Lys Glu Cys Gln Ala Pro Lys Arg Glu Leu Asn Gln Val 
        35                  40                  45              

Leu Tyr Arg Met Lys Lys Glu Leu Lys Val Ser Leu Thr Ser Pro Ala 
    50                  55                  60                  

Thr Trp Cys Leu Gly Gly Thr Asp Pro Glu Gly Glu Gly Pro Ala Glu 
65                  70                  75                  80  

Leu Ala Leu Ser Ser Pro Ala Lys Arg Pro Gln Gln His Ala Ala Thr 
                85                  90                  95      

Ile Pro Glu Thr Pro Gly Pro Gln Phe Ser Gln Gln Arg Glu Glu Asp 
            100                 105                 110         

Ile Tyr Arg Phe Leu Lys Asp Asn Gly Pro Gln Arg Ala Leu Val Ile 
        115                 120                 125             

Ala Gln Ala Leu Gly Met Arg Thr Ala Lys Asp Val Asn Arg Asp Leu 
    130                 135                 140                 

Tyr Arg Met Lys Ser Arg His Leu Leu Asp Met Asp Glu Gln Ser Lys 
145                 150                 155                 160 

Ala Trp Thr Ile Tyr Arg Pro Glu Asp Ser Gly Arg Arg Ala Lys Ser 
                165                 170                 175     

Ala Ser Ile Ile Tyr Gln His Asn Pro Ile Asn Met Ile Cys Gln Asn 
            180                 185                 190         

Gly Pro Asn Ser Trp Ile Ser Ile Ala Asn Ser Glu Ala Ile Gln Ile 
        195                 200                 205             

Gly His Gly Asn Ile Ile Thr Arg Gln Thr Val Ser Arg Glu Asp Gly 
    210                 215                 220                 

Ser Ala Gly Pro Arg His Leu Pro Ser Met Ala Pro Gly Asp Ser Ser 
225                 230                 235                 240 

Thr Trp Gly Thr Leu Val Asp Pro Trp Gly Pro Gln Asp Ile His Met 
                245                 250                 255     


Glu Arg Ser Ile Leu Arg Arg Val Gln Leu Gly His Ser Asn Glu Met 
            260                 265                 270         

Arg Leu His Gly Val Pro Ser Glu Gly Pro Ala His Ile Pro Pro Gly 
        275                 280                 285             

Ser Pro Pro Val Ser Ala Thr Ala Ala Gly Pro Glu Ala Ser Phe Glu 
    290                 295                 300                 

Ala Arg Ile Pro Ser Pro Gly Thr His Pro Glu Gly Glu Ala Ala Gln 
305                 310                 315                 320 

Arg Ile His Met Lys Ser Cys Phe Leu Glu Asp Ala Thr Ile Gly Asn 
                325                 330                 335     

Ser Asn Lys Met Ser Ile Ser Pro Gly Val Ala Gly Pro Gly Gly Val 
            340                 345                 350         

Ala Gly Ser Gly Glu Gly Glu Pro Gly Glu Asp Ala Gly Arg Arg Pro 
        355                 360                 365             

Ala Asp Thr Gln Ser Arg Ser His Phe Pro Arg Asp Ile Gly Gln Pro 
    370                 375                 380                 

Ile Thr Pro Ser His Ser Lys Leu Thr Pro Lys Leu Glu Thr Met Thr 
385                 390                 395                 400 

Leu Gly Asn Arg Ser His Lys Ala Ala Glu Gly Ser His Tyr Val Asp 
                405                 410                 415     

Glu Ala Ser His Glu Gly Ser Trp Trp Gly Gly Gly Ile 
            420                 425                 


<210>  14
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RIPK3 Protein

<400>  14

Met Ser Cys Val Lys Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val 
1               5                   10                  15      

Ser Ile Glu Glu Leu Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe 
            20                  25                  30          

Gly Thr Val Phe Arg Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala 
        35                  40                  45              

Val Lys Ile Val Asn Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met 
    50                  55                  60                  

Ala Ser Leu Asp Asn Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu 
65                  70                  75                  80  

Lys Val Asn Trp Asp Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe 
                85                  90                  95      

Met Glu Asn Gly Ser Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg 
            100                 105                 110         

Pro Trp Pro Leu Leu Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met 
        115                 120                 125             

Phe Tyr Leu His Asp Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys 
    130                 135                 140                 

Pro Ser Asn Val Leu Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp 
145                 150                 155                 160 

Phe Gly Leu Ser Thr Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser 
                165                 170                 175     

Gly Glu Pro Gly Gly Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val 
            180                 185                 190         

Asn Val Asn Arg Lys Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly 
        195                 200                 205             

Ile Leu Met Trp Ala Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr 
    210                 215                 220                 

Glu Pro Ser Leu Val Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro 
225                 230                 235                 240 

Ser Leu Ala Glu Leu Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu 
                245                 250                 255     

Gly Leu Lys Glu Leu Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp 
            260                 265                 270         

Arg Pro Ser Phe Gln Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln 
        275                 280                 285             

Met Val Glu Asn Asn Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe 
    290                 295                 300                 

Leu Ser Gln Leu Arg Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser 
305                 310                 315                 320 

Gly Gln Gly Gly Thr Glu Met Asp Gly Phe Arg Arg Thr Ile Glu Asn 
                325                 330                 335     

Gln His Ser Arg Asn Asp Val Met Val Ser Glu Trp Leu Asn Lys Leu 
            340                 345                 350         

Asn Leu Glu Glu Pro Pro Ser Ser Val Pro Lys Lys Cys Pro Ser Leu 
        355                 360                 365             

Thr Lys Arg Ser Arg Ala Gln Glu Glu Gln Val Pro Gln Ala Trp Thr 
    370                 375                 380                 


Ala Gly Thr Ser Ser Asp Ser Met Ala Gln Pro Pro Gln Thr Pro Glu 
385                 390                 395                 400 

Thr Ser Thr Phe Arg Asn Gln Met Pro Ser Pro Thr Ser Thr Gly Thr 
                405                 410                 415     

Pro Ser Pro Gly Pro Arg Gly Asn Gln Gly Ala Glu Arg Gln Gly Met 
            420                 425                 430         

Asn Trp Ser Cys Arg Thr Pro Glu Pro Asn Pro Val Thr Gly Arg Pro 
        435                 440                 445             

Leu Val Asn Ile Tyr Asn Cys Ser Gly Val Gln Val Gly Asp Asn Asn 
    450                 455                 460                 


Tyr Leu Thr Met Gln Gln Thr Thr Ala Leu Pro Thr Trp Gly Leu Ala 
465                 470                 475                 480 

Pro Ser Gly Lys Gly Arg Gly Leu Gln His Pro Pro Pro Val Gly Ser 
                485                 490                 495     

Gln Glu Gly Pro Lys Asp Pro Glu Ala Trp Ser Arg Pro Gln Gly Trp 
            500                 505                 510         

Tyr Asn His Ser Gly Lys 
        515             


<210>  15
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MLKL Protein

<400>  15

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      

Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          

His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              

Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  

Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  

Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      

Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         

Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             

Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 

Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 

Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     

Arg Gln Tyr Leu Pro Pro Lys Cys Met Gln Glu Ile Pro Gln Glu Gln 
            180                 185                 190         

Ile Lys Glu Ile Lys Lys Glu Gln Leu Ser Gly Ser Pro Trp Ile Leu 
        195                 200                 205             

Leu Arg Glu Asn Glu Val Ser Thr Leu Tyr Lys Gly Glu Tyr His Arg 
    210                 215                 220                 

Ala Pro Val Ala Ile Lys Val Phe Lys Lys Leu Gln Ala Gly Ser Ile 
225                 230                 235                 240 

Ala Ile Val Arg Gln Thr Phe Asn Lys Glu Ile Lys Thr Met Lys Lys 
                245                 250                 255     

Phe Glu Ser Pro Asn Ile Leu Arg Ile Phe Gly Ile Cys Ile Asp Glu 
            260                 265                 270         

Thr Val Thr Pro Pro Gln Phe Ser Ile Val Met Glu Tyr Cys Glu Leu 
        275                 280                 285             


Gly Thr Leu Arg Glu Leu Leu Asp Arg Glu Lys Asp Leu Thr Leu Gly 
    290                 295                 300                 

Lys Arg Met Val Leu Val Leu Gly Ala Ala Arg Gly Leu Tyr Arg Leu 
305                 310                 315                 320 

His His Ser Glu Ala Pro Glu Leu His Gly Lys Ile Arg Ser Ser Asn 
                325                 330                 335     

Phe Leu Val Thr Gln Gly Tyr Gln Val Lys Leu Ala Gly Phe Glu Leu 
            340                 345                 350         

Arg Lys Thr Gln Thr Ser Met Ser Leu Gly Thr Thr Arg Glu Lys Thr 
        355                 360                 365             

Asp Arg Val Lys Ser Thr Ala Tyr Leu Ser Pro Gln Glu Leu Glu Asp 
    370                 375                 380                 

Val Phe Tyr Gln Tyr Asp Val Lys Ser Glu Ile Tyr Ser Phe Gly Ile 
385                 390                 395                 400 

Val Leu Trp Glu Ile Ala Thr Gly Asp Ile Pro Phe Gln Gly Cys Asn 
                405                 410                 415     

Ser Glu Lys Ile Arg Lys Leu Val Ala Val Lys Arg Gln Gln Glu Pro 
            420                 425                 430         

Leu Gly Glu Asp Cys Pro Ser Glu Leu Arg Glu Ile Ile Asp Glu Cys 
        435                 440                 445             

Arg Ala His Asp Pro Ser Val Arg Pro Ser Val Asp Glu Ile Leu Lys 
    450                 455                 460                 

Lys Leu Ser Thr Phe Ser Lys 
465                 470     


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR 1

<400>  16
tctggagtca cacaagagtc ccct                                              24


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR 2

<400>  17
gctcagtaca tctacatgga caagtccttg                                        30


<210>  18
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Universal genomic viral RNA (vRNA) primer

<400>  18
agcaaaagca gg                                                           12


<210>  19
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 1

<400>  19
atggaaagaa taaaagaact aag                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer 2

<400>  20
ctaattgatg gccatccgaa ttc                                               23


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targeted sequence

<400>  21
tgagaacgtt ctgctcctgc                                                   20


