                         SEQUENCE LISTING

<110>  European Molecular Biology Laboratory
 
<120>  POLYPEPTIDE FRAGMENTS COMPRISING CTD BINDING DOMAIN

<130>  492-59 PCT

<150>  16 178 396.4
<151>  July 7, 2016

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  713
<212>  PRT
<213>  Influenza A virus

<400>  1

Met Glu Asn Phe Val Arg Thr Asn Phe Asn Pro Met Ile Leu Glu Arg 
1               5                   10                  15      


Ala Glu Lys Thr Met Lys Glu Tyr Gly Glu Asn Pro Gln Asn Glu Gly 
            20                  25                  30          


Asn Lys Phe Ala Ala Ile Ser Thr His Met Glu Val Cys Phe Met Tyr 
        35                  40                  45              


Ser Asp Phe His Phe Ile Asp Leu Glu Gly Asn Thr Ile Val Lys Glu 
    50                  55                  60                  


Asn Asp Asp Asp Asn Ala Met Leu Lys His Arg Phe Glu Ile Ile Glu 
65                  70                  75                  80  


Gly Gln Glu Arg Asn Ile Ala Trp Thr Ile Val Asn Ser Ile Cys Asn 
                85                  90                  95      


Met Thr Glu Asn Ser Lys Pro Arg Phe Leu Pro Asp Leu Tyr Asp Tyr 
            100                 105                 110         


Lys Thr Asn Lys Phe Ile Glu Ile Gly Val Thr Arg Arg Lys Val Glu 
        115                 120                 125             


Asp Tyr Tyr Tyr Glu Lys Ala Ser Lys Leu Lys Gly Glu Asn Val Tyr 
    130                 135                 140                 


Ile His Ile Phe Ser Phe Asp Gly Glu Glu Met Ala Thr Asp Asp Glu 
145                 150                 155                 160 


Tyr Ile Leu Asp Glu Glu Ser Arg Ala Arg Ile Lys Thr Arg Leu Phe 
                165                 170                 175     


Val Leu Arg Gln Glu Leu Ala Thr Ala Gly Leu Trp Asp Ser Phe Arg 
            180                 185                 190         


Gln Ser Glu Lys Gly Glu Glu Thr Leu Glu Glu Glu Phe Ser Tyr Pro 
        195                 200                 205             


Pro Thr Phe Gln Arg Leu Ala Asn Gln Ser Leu Pro Pro Ser Phe Lys 
    210                 215                 220                 


Asp Tyr His Gln Phe Lys Ala Tyr Val Ser Ser Phe Lys Ala Asn Gly 
225                 230                 235                 240 


Asn Ile Glu Ala Lys Leu Gly Ala Met Ser Glu Lys Val Asn Ala Gln 
                245                 250                 255     


Ile Glu Ser Phe Asp Pro Arg Thr Ile Arg Glu Leu Glu Leu Pro Glu 
            260                 265                 270         


Gly Lys Phe Cys Thr Gln Arg Ser Lys Phe Leu Leu Met Asp Ala Met 
        275                 280                 285             


Lys Leu Ser Val Leu Asn Pro Ala His Glu Gly Glu Gly Ile Pro Met 
    290                 295                 300                 


Lys Asp Ala Lys Ala Cys Leu Asp Thr Phe Trp Gly Trp Lys Lys Ala 
305                 310                 315                 320 


Thr Ile Ile Lys Lys His Glu Lys Gly Val Asn Thr Asn Tyr Leu Met 
                325                 330                 335     


Ile Trp Glu Gln Leu Leu Glu Ser Ile Lys Glu Met Glu Gly Lys Phe 
            340                 345                 350         


Leu Asn Leu Lys Lys Thr Asn His Leu Lys Trp Gly Leu Gly Glu Gly 
        355                 360                 365             


Gln Ala Pro Glu Lys Met Asp Phe Glu Asp Cys Lys Glu Val Pro Asp 
    370                 375                 380                 


Leu Phe Gln Tyr Lys Ser Glu Pro Pro Glu Lys Arg Lys Leu Ala Ser 
385                 390                 395                 400 


Trp Ile Gln Ser Glu Phe Asn Lys Ala Ser Glu Leu Thr Asn Ser Asn 
                405                 410                 415     


Trp Ile Glu Phe Asp Glu Leu Gly Asn Asp Val Ala Pro Ile Glu His 
            420                 425                 430         


Ile Ala Ser Arg Arg Arg Asn Phe Phe Thr Ala Glu Val Ser Gln Cys 
        435                 440                 445             


Arg Ala Ser Glu Tyr Ile Met Lys Ala Val Tyr Ile Asn Thr Ala Leu 
    450                 455                 460                 


Leu Asn Ser Ser Cys Thr Ala Met Glu Glu Tyr Gln Val Ile Pro Ile 
465                 470                 475                 480 


Ile Thr Lys Cys Arg Asp Thr Ser Gly Gln Arg Arg Thr Asn Leu Tyr 
                485                 490                 495     


Gly Phe Ile Ile Lys Gly Arg Ser His Leu Arg Asn Asp Thr Asp Val 
            500                 505                 510         


Val Asn Phe Ile Ser Leu Glu Phe Ser Leu Thr Asp Pro Arg Asn Glu 
        515                 520                 525             


Ile His Lys Trp Glu Lys Tyr Cys Val Leu Glu Ile Gly Asp Met Glu 
    530                 535                 540                 


Ile Arg Thr Ser Ile Ser Thr Ile Met Lys Pro Val Tyr Leu Tyr Val 
545                 550                 555                 560 


Arg Thr Asn Gly Thr Ser Lys Ile Lys Met Lys Trp Gly Met Glu Met 
                565                 570                 575     


Arg Arg Cys Leu Leu Gln Ser Leu Gln Gln Val Glu Ser Met Ile Glu 
            580                 585                 590         


Ala Glu Ser Ala Val Lys Glu Lys Asp Met Thr Glu Pro Phe Phe Arg 
        595                 600                 605             


Asn Arg Glu Asn Asp Trp Pro Ile Gly Glu Ser Pro Gln Gly Ile Glu 
    610                 615                 620                 


Lys Gly Thr Ile Gly Lys Val Cys Arg Val Leu Leu Ala Lys Ser Val 
625                 630                 635                 640 


Phe Asn Ser Ile Tyr Ala Ser Ala Gln Leu Glu Gly Phe Ser Ala Glu 
                645                 650                 655     


Ser Arg Lys Leu Leu Leu Leu Ile Gln Ala Phe Arg Asp Asn Leu Asp 
            660                 665                 670         


Pro Gly Thr Phe Asp Leu Lys Gly Leu Tyr Glu Ala Ile Glu Glu Cys 
        675                 680                 685             


Ile Ile Asn Asp Pro Trp Val Leu Leu Asn Ala Ser Trp Phe Asn Ser 
    690                 695                 700                 


Phe Leu Lys Ala Val Gln Leu Ser Met 
705                 710             


<210>  2
<211>  726
<212>  PRT
<213>  Influenza B virus

<400>  2

Met Asp Thr Phe Ile Thr Arg Asn Phe Gln Thr Thr Ile Ile Gln Lys 
1               5                   10                  15      


Ala Lys Asn Thr Met Ala Glu Phe Ser Glu Asp Pro Glu Leu Gln Pro 
            20                  25                  30          


Ala Met Leu Phe Asn Ile Cys Val His Leu Glu Val Cys Tyr Val Ile 
        35                  40                  45              


Ser Asp Met Asn Phe Leu Asp Glu Glu Gly Lys Ala Tyr Thr Ala Leu 
    50                  55                  60                  


Glu Gly Gln Gly Lys Glu Gln Asn Leu Arg Pro Gln Tyr Glu Val Ile 
65                  70                  75                  80  


Glu Gly Met Pro Arg Thr Ile Ala Trp Met Val Gln Arg Ser Leu Ala 
                85                  90                  95      


Gln Glu His Gly Ile Glu Thr Pro Lys Tyr Leu Ala Asp Leu Phe Asp 
            100                 105                 110         


Tyr Lys Thr Lys Arg Phe Ile Glu Val Gly Ile Thr Lys Gly Leu Ala 
        115                 120                 125             


Asp Asp Tyr Phe Trp Lys Lys Lys Glu Lys Leu Gly Asn Ser Met Glu 
    130                 135                 140                 


Leu Met Ile Phe Ser Tyr Asn Gln Asp Tyr Ser Leu Ser Asn Glu Ser 
145                 150                 155                 160 


Ser Leu Asp Glu Glu Gly Lys Gly Arg Val Leu Ser Arg Leu Thr Glu 
                165                 170                 175     


Leu Gln Ala Glu Leu Ser Leu Lys Asn Leu Trp Gln Val Leu Ile Gly 
            180                 185                 190         


Glu Glu Asp Val Glu Lys Gly Ile Asp Phe Lys Leu Gly Gln Thr Ile 
        195                 200                 205             


Ser Arg Leu Arg Asp Ile Ser Val Pro Ala Gly Phe Ser Asn Phe Glu 
    210                 215                 220                 


Gly Met Arg Ser Tyr Ile Asp Asn Ile Asp Pro Lys Gly Ala Ile Glu 
225                 230                 235                 240 


Arg Asn Leu Ala Arg Met Ser Pro Leu Val Ser Val Thr Pro Lys Lys 
                245                 250                 255     


Leu Thr Trp Glu Asp Leu Arg Pro Ile Gly Pro His Ile Tyr Asn His 
            260                 265                 270         


Glu Leu Pro Glu Val Pro Tyr Asn Ala Phe Leu Leu Met Ser Asp Glu 
        275                 280                 285             


Leu Gly Leu Ala Asn Met Thr Glu Gly Lys Ser Lys Lys Pro Lys Thr 
    290                 295                 300                 


Leu Ala Lys Glu Cys Leu Glu Lys Tyr Ser Thr Leu Arg Asp Gln Thr 
305                 310                 315                 320 


Asp Pro Ile Leu Ile Met Lys Ser Glu Lys Ala Asn Glu Asn Phe Leu 
                325                 330                 335     


Trp Lys Leu Trp Arg Asp Cys Val Asn Thr Ile Ser Asn Glu Glu Met 
            340                 345                 350         


Ser Asn Glu Leu Gln Lys Thr Asn Tyr Ala Lys Trp Ala Thr Gly Asp 
        355                 360                 365             


Gly Leu Thr Tyr Gln Lys Ile Met Lys Glu Val Ala Ile Asp Asp Glu 
    370                 375                 380                 


Thr Met Cys Gln Glu Glu Pro Lys Ile Pro Asn Lys Cys Arg Val Ala 
385                 390                 395                 400 


Ala Trp Val Gln Thr Glu Met Asn Leu Leu Ser Thr Leu Thr Ser Lys 
                405                 410                 415     


Arg Ala Leu Asp Leu Pro Glu Ile Gly Pro Asp Val Ala Pro Val Glu 
            420                 425                 430         


His Val Gly Ser Glu Arg Arg Lys Tyr Phe Val Asn Glu Ile Asn Tyr 
        435                 440                 445             


Cys Lys Ala Ser Thr Val Met Met Lys Tyr Val Leu Phe His Thr Ser 
    450                 455                 460                 


Leu Leu Asn Glu Ser Asn Ala Ser Met Gly Lys Tyr Lys Val Ile Pro 
465                 470                 475                 480 


Ile Thr Asn Arg Val Val Asn Glu Lys Gly Glu Ser Phe Asp Met Leu 
                485                 490                 495     


Tyr Gly Leu Ala Val Lys Gly Gln Ser His Leu Arg Gly Asp Thr Asp 
            500                 505                 510         


Val Val Thr Val Val Thr Phe Glu Phe Ser Ser Thr Asp Pro Arg Val 
        515                 520                 525             


Asp Ser Gly Lys Trp Pro Lys Tyr Thr Val Phe Arg Ile Gly Ser Leu 
    530                 535                 540                 


Phe Val Ser Gly Arg Glu Lys Ser Val Tyr Leu Tyr Cys Arg Val Asn 
545                 550                 555                 560 


Gly Thr Asn Lys Ile Gln Met Lys Trp Gly Met Glu Ala Arg Arg Cys 
                565                 570                 575     


Leu Leu Gln Ser Met Gln Gln Met Glu Ala Ile Val Glu Gln Glu Ser 
            580                 585                 590         


Ser Ile Gln Gly Tyr Asp Met Thr Lys Ala Cys Phe Lys Gly Asp Arg 
        595                 600                 605             


Val Asn Ser Pro Lys Thr Phe Ser Ile Gly Thr Gln Glu Gly Lys Leu 
    610                 615                 620                 


Val Lys Gly Ser Phe Gly Lys Ala Leu Arg Val Ile Phe Thr Lys Cys 
625                 630                 635                 640 


Leu Met His Tyr Val Phe Gly Asn Ala Gln Leu Glu Gly Phe Ser Ala 
                645                 650                 655     


Glu Ser Arg Arg Leu Leu Leu Leu Ile Gln Ala Leu Lys Asp Arg Lys 
            660                 665                 670         


Gly Pro Trp Val Phe Asp Leu Glu Gly Met Tyr Ser Gly Ile Glu Glu 
        675                 680                 685             


Cys Ile Ser Asn Asn Pro Trp Val Ile Gln Ser Ala Tyr Trp Phe Asn 
    690                 695                 700                 


Glu Trp Leu Gly Phe Glu Lys Glu Gly Ser Lys Val Leu Glu Ser Val 
705                 710                 715                 720 


Asp Glu Ile Met Asp Glu 
                725     


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide

<400>  3

Gly Met Gly Ser Gly Met Ala 
1               5           


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AviTag

<400>  4

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  5
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Calmodulin-tag

<400>  5

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polyglutamate tag

<400>  6

Glu Glu Glu Glu Glu Glu 
1               5       


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-tag

<400>  7

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG-tag

<400>  8

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-tag

<400>  9

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tag

<400>  10

His His His His His His 
1               5       


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc-tag

<400>  11

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-tag

<400>  12

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  13
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SBP-tag

<400>  13

Met Asp Glu Lys Thr Thr Gly Trp Arg Gly Gly His Val Val Glu Gly 
1               5                   10                  15      


Leu Ala Gly Glu Leu Glu Gln Leu Arg Ala Arg Leu Glu His His Pro 
            20                  25                  30          


Gln Gly Gln Arg Glu Pro 
        35              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 1

<400>  14

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 3

<400>  15

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep-tag

<400>  16

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TC tag

<400>  17

Cys Cys Pro Gly Cys Cys 
1               5       


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  18

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSV

<400>  19

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xpress tag

<400>  20

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV protease recognition site

<400>  21

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Isopeptag

<400>  22

Thr Asp Lys Asp Met Thr Ile Thr Phe Thr Asn Lys Lys Asp Ala Glu 
1               5                   10                  15      


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpyTag

<400>  23

Ala His Ile Val Met Val Asp Ala Tyr Lys Pro Thr Lys 
1               5                   10              


<210>  24
<211>  13
<212>  RNA
<213>  Influenza A virus

<400>  24
aguagaaaca agg                                                          13


<210>  25
<211>  13
<212>  RNA
<213>  Influenza A virus

<400>  25
gccugcuucu gcu                                                          13


<210>  26
<211>  14
<212>  RNA
<213>  Influenza B virus

<400>  26
aguaguaaca agag                                                         14


<210>  27
<211>  13
<212>  RNA
<213>  Influenza B virus

<400>  27
cucugcuucu gcu                                                          13


<210>  28
<211>  14
<212>  RNA
<213>  Influenza A virus

<400>  28
aguaguaaca agag                                                         14


<210>  29
<211>  14
<212>  RNA
<213>  Influenza A virus

<400>  29
agcagaagca gagg                                                         14


<210>  30
<211>  18
<212>  RNA
<213>  Influenza A virus

<400>  30
uauaccucug cuucugcu                                                     18


<210>  31
<211>  18
<212>  RNA
<213>  Influenza A virus

<400>  31
uacccucuug uuacuacu                                                     18


<210>  32
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  capped primer

<400>  32
gaaucuauaa uag                                                          13


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer1

<400>  33
agtagaaaca aggtactttt ttgg                                              24


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer2

<400>  34
tgcaggacat tgagaatgag g                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  35
acctcaattc tggttcatca c                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
agcgaaagca ggtactgatc c                                                 21


<210>  37
<211>  716
<212>  PRT
<213>  Influenza A virus

<400>  37

Met Glu Asp Phe Val Arg Gln Cys Phe Asn Pro Met Ile Val Glu Leu 
1               5                   10                  15      


Ala Glu Lys Ala Met Lys Glu Tyr Gly Glu Asp Leu Lys Ile Glu Thr 
            20                  25                  30          


Asn Lys Phe Ala Ala Ile Cys Thr His Leu Glu Val Cys Phe Met Tyr 
        35                  40                  45              


Ser Asp Phe His Phe Ile Asp Glu Gln Gly Glu Ser Ile Val Val Glu 
    50                  55                  60                  


Leu Gly Asp Pro Asn Ala Leu Leu Lys His Arg Phe Glu Ile Ile Glu 
65                  70                  75                  80  


Gly Arg Asp Arg Thr Ile Ala Trp Thr Val Ile Asn Ser Ile Cys Asn 
                85                  90                  95      


Thr Thr Gly Ala Glu Lys Pro Lys Phe Leu Pro Asp Leu Tyr Asp Tyr 
            100                 105                 110         


Lys Lys Asn Arg Phe Ile Glu Ile Gly Val Thr Arg Arg Glu Val His 
        115                 120                 125             


Ile Tyr Tyr Leu Glu Lys Ala Asn Lys Ile Lys Ser Glu Lys Thr His 
    130                 135                 140                 


Ile His Ile Phe Ser Phe Thr Gly Glu Glu Met Ala Thr Lys Ala Asp 
145                 150                 155                 160 


Tyr Thr Leu Asp Glu Glu Ser Arg Ala Arg Ile Lys Thr Arg Leu Phe 
                165                 170                 175     


Thr Ile Arg Gln Glu Met Ala Ser Arg Gly Leu Trp Asp Ser Phe Arg 
            180                 185                 190         


Gln Ser Glu Arg Gly Glu Glu Thr Ile Glu Glu Arg Phe Glu Ile Thr 
        195                 200                 205             


Gly Thr Met Arg Lys Leu Ala Asp Gln Ser Leu Pro Pro Asn Phe Ser 
    210                 215                 220                 


Ser Leu Glu Asn Phe Arg Ala Tyr Val Asp Gly Phe Glu Pro Asn Gly 
225                 230                 235                 240 


Tyr Ile Glu Gly Lys Leu Ser Gln Met Ser Lys Glu Val Asn Ala Arg 
                245                 250                 255     


Ile Glu Pro Phe Leu Lys Ser Thr Pro Arg Pro Leu Arg Leu Pro Asp 
            260                 265                 270         


Gly Pro Pro Cys Ser Gln Arg Ser Lys Phe Leu Leu Met Asp Ala Leu 
        275                 280                 285             


Lys Leu Ser Ile Glu Asp Pro Ser His Glu Gly Glu Gly Ile Pro Leu 
    290                 295                 300                 


Tyr Asp Ala Ile Lys Cys Met Arg Thr Phe Phe Gly Trp Lys Glu Pro 
305                 310                 315                 320 


Asn Val Val Lys Pro His Glu Lys Gly Ile Asn Pro Asn Tyr Leu Leu 
                325                 330                 335     


Ser Trp Lys Gln Val Leu Ala Glu Leu Gln Asp Ile Glu Asn Glu Glu 
            340                 345                 350         


Lys Ile Pro Arg Thr Lys Asn Met Lys Lys Thr Ser Gln Leu Lys Trp 
        355                 360                 365             


Ala Leu Gly Glu Asn Met Ala Pro Glu Lys Val Asp Phe Asp Asp Cys 
    370                 375                 380                 


Lys Asp Val Gly Asp Leu Lys Gln Tyr Asp Ser Asp Glu Pro Glu Leu 
385                 390                 395                 400 


Arg Ser Leu Ala Ser Trp Ile Gln Asn Glu Phe Asn Lys Ala Cys Glu 
                405                 410                 415     


Leu Thr Asp Ser Ser Trp Ile Glu Leu Asp Glu Ile Gly Glu Asp Ala 
            420                 425                 430         


Ala Pro Ile Glu His Ile Ala Ser Met Arg Arg Asn Tyr Phe Thr Ala 
        435                 440                 445             


Glu Val Ser His Cys Arg Ala Thr Glu Tyr Ile Met Lys Gly Val Tyr 
    450                 455                 460                 


Ile Asn Thr Ala Leu Leu Asn Ala Ser Cys Ala Ala Met Asp Asp Phe 
465                 470                 475                 480 


Gln Leu Ile Pro Met Ile Ser Lys Cys Arg Thr Lys Glu Gly Arg Arg 
                485                 490                 495     


Lys Thr Asn Leu Tyr Gly Phe Ile Ile Lys Gly Arg Ser His Leu Arg 
            500                 505                 510         


Asn Asp Thr Asp Val Val Asn Phe Val Ser Met Glu Phe Ser Leu Thr 
        515                 520                 525             


Asp Pro Arg Leu Glu Pro His Lys Trp Glu Lys Tyr Cys Val Leu Glu 
    530                 535                 540                 


Val Gly Asp Met Leu Leu Arg Ser Ala Ile Gly His Val Ser Arg Pro 
545                 550                 555                 560 


Met Phe Leu Tyr Val Arg Thr Asn Gly Thr Ser Lys Ile Lys Met Lys 
                565                 570                 575     


Trp Gly Met Glu Met Arg Arg Cys Leu Leu Gln Ser Leu Gln Gln Ile 
            580                 585                 590         


Glu Ser Met Ile Glu Ala Glu Ser Ser Val Lys Glu Lys Asp Met Thr 
        595                 600                 605             


Lys Glu Phe Phe Glu Asn Lys Ser Glu Thr Trp Pro Val Gly Glu Ser 
    610                 615                 620                 


Pro Lys Gly Val Glu Glu Gly Ser Ile Gly Lys Val Cys Arg Thr Leu 
625                 630                 635                 640 


Leu Ala Lys Ser Val Phe Asn Ser Leu Tyr Ala Ser Pro Gln Leu Glu 
                645                 650                 655     


Gly Phe Ser Ala Glu Ser Arg Lys Leu Leu Leu Ile Val Gln Ala Leu 
            660                 665                 670         


Arg Asp Asn Leu Glu Pro Gly Thr Phe Asp Leu Gly Gly Leu Tyr Glu 
        675                 680                 685             


Ala Ile Glu Glu Cys Leu Ile Asn Asp Pro Trp Val Leu Leu Asn Ala 
    690                 695                 700                 


Ser Trp Phe Asn Ser Phe Leu Thr His Ala Leu Arg 
705                 710                 715     


<210>  38
<211>  716
<212>  PRT
<213>  Influenza A virus

<400>  38

Met Glu Asp Phe Val Arg Gln Cys Phe Asn Pro Met Ile Val Glu Leu 
1               5                   10                  15      


Ala Glu Lys Ala Met Lys Glu Tyr Gly Glu Asp Pro Lys Ile Glu Thr 
            20                  25                  30          


Asn Lys Phe Ala Ala Ile Cys Thr His Leu Glu Val Cys Phe Met Tyr 
        35                  40                  45              


Ser Asp Phe His Phe Ile Asp Glu Arg Ser Glu Ser Ile Ile Val Glu 
    50                  55                  60                  


Ser Gly Asp Pro Asn Ala Leu Leu Lys His Arg Phe Glu Ile Ile Glu 
65                  70                  75                  80  


Gly Arg Asp Arg Thr Met Ala Trp Thr Val Val Asn Ser Ile Cys Asn 
                85                  90                  95      


Thr Thr Gly Val Glu Lys Pro Lys Phe Leu Pro Asp Leu Tyr Asp Tyr 
            100                 105                 110         


Lys Glu Asn Arg Phe Ile Glu Ile Gly Val Thr Arg Arg Glu Val His 
        115                 120                 125             


Thr Tyr Tyr Leu Glu Lys Ala Asn Lys Ile Lys Ser Glu Lys Thr His 
    130                 135                 140                 


Ile His Ile Phe Ser Phe Thr Gly Glu Glu Met Ala Thr Lys Ala Asp 
145                 150                 155                 160 


Tyr Thr Leu Asp Glu Glu Ser Arg Ala Arg Ile Lys Thr Arg Leu Phe 
                165                 170                 175     


Thr Ile Arg Gln Glu Met Ala Ser Arg Gly Leu Trp Asp Ser Phe Arg 
            180                 185                 190         


Gln Ser Glu Arg Gly Glu Glu Thr Ile Glu Glu Lys Phe Glu Ile Thr 
        195                 200                 205             


Gly Thr Met Arg Arg Leu Ala Asp Gln Ser Leu Pro Pro Asn Phe Ser 
    210                 215                 220                 


Ser Leu Glu Asn Phe Arg Ala Tyr Val Asp Gly Phe Glu Pro Asn Gly 
225                 230                 235                 240 


Cys Ile Glu Gly Lys Leu Ser Gln Met Ser Lys Glu Val Asn Ala Arg 
                245                 250                 255     


Ile Glu Pro Phe Leu Lys Thr Thr Pro Arg Pro Leu Arg Leu Pro Asp 
            260                 265                 270         


Gly Pro Pro Cys Ser Gln Arg Ser Lys Phe Leu Leu Met Asp Ala Leu 
        275                 280                 285             


Lys Leu Ser Ile Glu Asp Pro Ser His Glu Gly Glu Gly Ile Pro Leu 
    290                 295                 300                 


Tyr Asp Ala Ile Lys Cys Met Lys Thr Phe Phe Gly Trp Lys Glu Pro 
305                 310                 315                 320 


Asn Ile Val Lys Pro His Glu Lys Gly Ile Asn Pro Asn Tyr Leu Leu 
                325                 330                 335     


Ala Trp Lys Gln Val Leu Ala Glu Leu Gln Asp Ile Glu Asn Glu Glu 
            340                 345                 350         


Lys Ile Pro Lys Thr Lys Asn Met Lys Lys Thr Ser Gln Leu Lys Trp 
        355                 360                 365             


Ala Leu Gly Glu Asn Met Ala Pro Glu Lys Val Asp Phe Glu Asp Cys 
    370                 375                 380                 


Lys Asp Val Ser Asp Leu Arg Gln Tyr Asp Ser Asp Glu Pro Glu Ser 
385                 390                 395                 400 


Arg Ser Leu Ala Ser Trp Ile Gln Ser Glu Phe Asn Lys Ala Cys Glu 
                405                 410                 415     


Leu Thr Asp Ser Ser Trp Ile Glu Leu Asp Glu Ile Gly Glu Asp Val 
            420                 425                 430         


Ala Pro Ile Glu His Ile Ala Ser Met Arg Arg Asn Tyr Phe Thr Ala 
        435                 440                 445             


Glu Val Ser His Cys Arg Ala Thr Glu Tyr Ile Met Lys Gly Val Tyr 
    450                 455                 460                 


Ile Asn Thr Ala Leu Leu Asn Ala Ser Cys Ala Ala Met Asp Asp Phe 
465                 470                 475                 480 


Gln Leu Ile Pro Met Ile Ser Lys Cys Arg Thr Lys Glu Gly Arg Arg 
                485                 490                 495     


Lys Thr Asn Leu Tyr Gly Phe Ile Ile Lys Gly Arg Ser His Leu Arg 
            500                 505                 510         


Asn Asp Thr Asp Val Val Asn Phe Val Ser Met Glu Phe Ser Leu Thr 
        515                 520                 525             


Asp Pro Arg Leu Glu Pro His Lys Trp Glu Lys Tyr Cys Val Leu Glu 
    530                 535                 540                 


Ile Gly Asp Met Leu Leu Arg Thr Ala Val Gly Gln Val Ser Arg Pro 
545                 550                 555                 560 


Met Phe Leu Tyr Val Arg Thr Asn Gly Thr Ser Lys Ile Lys Met Lys 
                565                 570                 575     


Trp Gly Met Glu Met Arg Arg Cys Leu Leu Gln Ser Leu Gln Gln Ile 
            580                 585                 590         


Glu Ser Met Ile Glu Ala Glu Ser Ser Val Lys Glu Lys Asp Met Thr 
        595                 600                 605             


Lys Glu Phe Phe Glu Asn Lys Ser Glu Thr Trp Pro Ile Gly Glu Ser 
    610                 615                 620                 


Pro Lys Gly Val Glu Glu Gly Ser Ile Gly Lys Val Cys Arg Thr Leu 
625                 630                 635                 640 


Leu Ala Lys Ser Val Phe Asn Ser Leu Tyr Ala Ser Pro Gln Leu Glu 
                645                 650                 655     


Gly Phe Ser Ala Glu Ser Arg Lys Leu Leu Leu Ile Ala Gln Ala Leu 
            660                 665                 670         


Arg Asp Asn Leu Glu Pro Gly Thr Phe Asp Leu Gly Gly Leu Tyr Glu 
        675                 680                 685             


Ala Ile Glu Glu Cys Leu Ile Asn Asp Pro Trp Val Leu Leu Asn Ala 
    690                 695                 700                 


Ser Trp Phe Asn Ser Phe Leu Ala His Ala Leu Lys 
705                 710                 715     


<210>  39
<211>  709
<212>  PRT
<213>  Influenza C virus

<400>  39

Met Ser Lys Thr Phe Ala Glu Ile Ala Glu Ala Phe Leu Glu Pro Glu 
1               5                   10                  15      


Ala Val Arg Ile Ala Lys Glu Ala Val Glu Glu Tyr Gly Asp His Glu 
            20                  25                  30          


Arg Lys Ile Ile Gln Ile Gly Ile His Phe Gln Val Cys Cys Met Phe 
        35                  40                  45              


Cys Asp Glu Tyr Leu Ser Thr Asn Gly Ser Asp Arg Phe Val Leu Ile 
    50                  55                  60                  


Glu Gly Arg Lys Arg Gly Thr Ala Val Ser Leu Gln Asn Glu Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Asp Leu Glu Pro Leu Pro Phe Leu Cys Asp Ile Phe Asp 
                85                  90                  95      


Arg Glu Glu Lys Gln Phe Val Glu Ile Gly Ile Thr Arg Lys Ala Asp 
            100                 105                 110         


Asp Ser Tyr Phe Gln Ser Lys Phe Gly Lys Leu Gly Asn Ser Cys Lys 
        115                 120                 125             


Ile Phe Val Phe Ser Tyr Asp Gly Arg Leu Asp Lys Asn Cys Glu Gly 
    130                 135                 140                 


Pro Met Glu Glu Gln Lys Leu Arg Ile Phe Ser Phe Leu Ala Thr Ala 
145                 150                 155                 160 


Ala Asp Phe Leu Arg Lys Glu Asn Met Phe Asn Glu Ile Phe Leu Pro 
                165                 170                 175     


Asp Asn Glu Glu Thr Ile Ile Glu Met Lys Lys Gly Lys Thr Phe Leu 
            180                 185                 190         


Glu Leu Arg Asp Glu Ser Val Pro Leu Pro Phe Gln Thr Tyr Glu Gln 
        195                 200                 205             


Met Lys Asp Tyr Cys Glu Lys Phe Lys Gly Asn Pro Arg Glu Leu Ala 
    210                 215                 220                 


Ser Lys Val Ser Gln Met Gln Ser Asn Ile Lys Leu Pro Ile Lys His 
225                 230                 235                 240 


Tyr Glu Gln Asn Lys Phe Arg Gln Ile Arg Leu Pro Lys Gly Pro Met 
                245                 250                 255     


Ala Pro Tyr Thr His Lys Phe Leu Met Glu Glu Ala Trp Met Phe Thr 
            260                 265                 270         


Lys Ile Ser Asp Pro Glu Arg Ser Arg Ala Gly Glu Ile Leu Ile Asp 
        275                 280                 285             


Phe Phe Lys Lys Gly Asn Leu Ser Ala Ile Arg Pro Lys Asp Lys Pro 
    290                 295                 300                 


Leu Gln Gly Lys Tyr Pro Ile His Tyr Lys Asn Leu Trp Asn Gln Ile 
305                 310                 315                 320 


Lys Ala Ala Ile Ala Asp Arg Thr Met Val Ile Asn Glu Asn Asp His 
                325                 330                 335     


Ser Glu Phe Leu Gly Gly Ile Gly Arg Ala Ser Lys Lys Ile Pro Glu 
            340                 345                 350         


Ile Ser Leu Thr Gln Asp Val Ile Thr Thr Glu Gly Leu Lys Gln Ser 
        355                 360                 365             


Glu Asn Lys Leu Pro Glu Pro Arg Ser Phe Pro Arg Trp Phe Asn Ala 
    370                 375                 380                 


Glu Trp Met Trp Ala Ile Lys Asp Ser Asp Leu Thr Gly Trp Val Pro 
385                 390                 395                 400 


Met Ala Glu Tyr Pro Pro Ala Asp Asn Glu Leu Glu Asp Tyr Ala Glu 
                405                 410                 415     


His Leu Asn Lys Thr Met Glu Gly Val Leu Gln Gly Thr Asn Cys Ala 
            420                 425                 430         


Arg Glu Met Gly Lys Cys Ile Leu Thr Val Gly Ala Leu Met Thr Glu 
        435                 440                 445             


Cys Arg Leu Phe Pro Gly Lys Ile Lys Val Val Pro Ile Tyr Ala Arg 
    450                 455                 460                 


Ser Lys Glu Arg Lys Ser Met Gln Glu Gly Leu Pro Val Pro Ser Glu 
465                 470                 475                 480 


Met Asp Cys Leu Phe Gly Ile Cys Val Lys Ser Lys Ser His Leu Asn 
                485                 490                 495     


Lys Asp Asp Gly Met Tyr Thr Ile Ile Thr Phe Glu Phe Ser Ile Arg 
            500                 505                 510         


Glu Pro Asn Leu Glu Lys His Gln Lys Tyr Thr Val Phe Glu Ala Gly 
        515                 520                 525             


His Thr Thr Val Arg Met Lys Lys Gly Glu Ser Val Ile Gly Arg Glu 
    530                 535                 540                 


Val Pro Leu Tyr Leu Tyr Cys Arg Thr Thr Ala Leu Ser Lys Ile Lys 
545                 550                 555                 560 


Asn Asp Trp Leu Ser Lys Ala Arg Arg Cys Phe Ile Thr Thr Met Asp 
                565                 570                 575     


Thr Val Glu Thr Ile Cys Leu Arg Glu Ser Ala Lys Ala Glu Glu Asn 
            580                 585                 590         


Leu Val Glu Lys Thr Leu Asn Glu Lys Gln Met Trp Ile Gly Lys Lys 
        595                 600                 605             


Asn Gly Glu Leu Ile Ala Gln Pro Leu Arg Glu Ala Leu Arg Val Gln 
    610                 615                 620                 


Leu Val Gln Gln Phe Tyr Phe Cys Ile Tyr Asn Asp Ser Gln Leu Glu 
625                 630                 635                 640 


Gly Phe Cys Asn Glu Gln Lys Lys Ile Leu Met Ala Leu Glu Gly Asp 
                645                 650                 655     


Lys Lys Asn Lys Ser Ser Phe Gly Phe Asn Pro Glu Gly Leu Leu Glu 
            660                 665                 670         


Lys Ile Glu Glu Cys Leu Ile Asn Asn Pro Met Cys Leu Phe Met Ala 
        675                 680                 685             


Gln Arg Leu Asn Glu Leu Val Ile Glu Ala Ser Lys Arg Gly Ala Lys 
    690                 695                 700                 


Phe Phe Lys Thr Asp 
705                 


<210>  40
<211>  710
<212>  PRT
<213>  Influenza virus

<400>  40

Met Ser Ser Ile Ile Arg Glu Ile Ala Lys Arg Phe Leu Glu Gln Ala 
1               5                   10                  15      


Thr Ile Asn Ile Ala Glu Glu Val Val Arg Glu Tyr Gly Asp His Glu 
            20                  25                  30          


Arg Thr Met Ile Ser Val Gly Val His Phe Gln Ala Cys Cys Leu Ile 
        35                  40                  45              


Ser Asp Glu Tyr Thr Leu Glu Asp Glu Thr Thr Pro Arg Tyr Val Leu 
    50                  55                  60                  


Leu Glu Gly Leu Arg Arg Gln Glu Ala Ile Ser Lys Gln Asn Asn Ile 
65                  70                  75                  80  


Cys Ser Thr Leu Gly Leu Glu Pro Leu Arg Asn Leu Ala Asp Ile Phe 
                85                  90                  95      


Asp Arg Lys Thr Arg Arg Phe Leu Glu Val Gly Ile Thr Lys Arg Glu 
            100                 105                 110         


Ser Asp Glu Tyr Tyr Gln Glu Lys Phe Asn Lys Ile Gly Asn Asp Met 
        115                 120                 125             


Asp Ile His Val Phe Thr Tyr Glu Gly Lys Tyr Phe Ser Asn Asn Pro 
    130                 135                 140                 


Asn Gly Leu Glu Asp Ile Gln Lys Thr Arg Ile Phe Thr Phe Leu Ser 
145                 150                 155                 160 


Phe Val Ser Asp Glu Leu Arg Lys Glu Asn Met Phe Thr Glu Met Tyr 
                165                 170                 175     


Val Thr Glu Glu Gly Ala Pro Glu Leu Glu Met Tyr Lys Ser Lys Leu 
            180                 185                 190         


Phe Ile Ala Met Arg Asp Glu Ser Val Pro Leu Pro Tyr Ile Asn Tyr 
        195                 200                 205             


Glu His Leu Arg Thr Arg Cys Glu Thr Phe Lys Arg Asn Gln Ala Glu 
    210                 215                 220                 


Cys Glu Ala Lys Val Ala Asp Val Ala Ser Arg Leu Lys Ile Lys Leu 
225                 230                 235                 240 


Glu His Leu Glu Glu Asn Lys Leu Arg Pro Leu Glu Ile Pro Lys Glu 
                245                 250                 255     


Arg Glu Ala Pro Tyr Thr His Lys Phe Met Met Lys Asp Ala Trp Phe 
            260                 265                 270         


Phe Ala Lys Pro His Asp Ser Glu Arg Ala Gln Pro Gln Gln Ile Leu 
        275                 280                 285             


Tyr Asp Phe Phe Glu Ala Ala Asn Met Gly Phe Met Thr Thr Ser Pro 
    290                 295                 300                 


Lys Pro Ile Phe Gly Lys Gln Gly Leu Met Tyr His Ser Leu Trp Gly 
305                 310                 315                 320 


Gln Ile Lys Arg Ala Ile Lys Asp Lys Arg Asn Glu Leu Glu Pro Ser 
                325                 330                 335     


Glu Gln Arg Asp Phe Leu Cys Gly Ile Gly Arg Ala Ser Lys Lys Ile 
            340                 345                 350         


Gln Glu Asp Lys Trp Gln Glu Ser Lys Glu Glu Glu Phe Lys Gln Glu 
        355                 360                 365             


Glu Thr Lys Gly Ala Ala Lys Arg Gly Phe Pro Thr Trp Phe Asn Glu 
    370                 375                 380                 


Glu Trp Leu Trp Ala Met Arg Asp Ser Gly Asp Gly Asp Asn Lys Ile 
385                 390                 395                 400 


Gly Asp Trp Ile Pro Met Ala Glu Met Pro Pro Cys Lys Asn Glu Met 
                405                 410                 415     


Glu Asp Tyr Ala Lys Lys Met Cys Glu Glu Leu Glu Ser Lys Ile Gln 
            420                 425                 430         


Gly Thr Asn Cys Ala Arg Glu Met Ser Lys Leu Ile His Thr Ile Gly 
        435                 440                 445             


Ser Leu His Thr Glu Cys Arg Asn Phe Pro Gly Lys Val Lys Ile Val 
    450                 455                 460                 


Pro Ile Tyr Cys Arg Gly Thr Leu Arg Gly Glu Ser Thr Asp Cys Leu 
465                 470                 475                 480 


Phe Gly Ile Ala Ile Lys Gly Lys Ser His Leu Asn Lys Asp Asp Gly 
                485                 490                 495     


Met Tyr Thr Val Val Thr Phe Glu Phe Ser Thr Glu Lys Pro Asn Pro 
            500                 505                 510         


Ser Lys His Glu Lys Tyr Thr Val Phe Glu Ala Gly Thr Val Pro Val 
        515                 520                 525             


Glu Ala Val Val Leu Thr Pro Lys Arg Glu Arg Val Leu Lys Glu Lys 
    530                 535                 540                 


Lys Leu Phe Leu Tyr Cys Arg Thr Thr Gly Met Ser Lys Leu Lys Asn 
545                 550                 555                 560 


Asp Trp Phe Ser Lys Cys Arg Arg Cys Leu Ile Pro Thr Met Glu Thr 
                565                 570                 575     


Val Glu Gln Ile Val Leu Lys Glu Cys Ala Leu Lys Glu Glu Asn Arg 
            580                 585                 590         


Val Ser Glu Met Leu Glu Asn Lys Arg Ala Trp Ile Ala His Glu Asn 
        595                 600                 605             


Gly Glu Asn Leu Thr Arg Leu Val Ser Thr Lys Leu Lys Asp Leu Cys 
    610                 615                 620                 


Arg Met Leu Ile Val Thr Gln Phe Tyr Tyr Cys Ile Tyr Asn Asp Asn 
625                 630                 635                 640 


Gln Leu Glu Gly Phe Cys Asn Glu Gln Lys Lys Phe Leu Met Phe Leu 
                645                 650                 655     


Gln Ala Asp Lys Asp Ser Lys Ser Ala Phe Thr Phe Asn Gln Lys Gly 
            660                 665                 670         


Leu Tyr Glu Lys Ile Glu Glu Cys Ile Val Ser Asn Pro Leu Cys Ile 
        675                 680                 685             


Phe Leu Ala Asp Arg Leu Asn Lys Leu Phe Leu Val Ala Lys Ser Asn 
    690                 695                 700                 


Gly Ala Lys Tyr Phe Glu 
705                 710 


<210>  41
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H7N9/PB1_full length

<400>  41

Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Val Pro Val Gln Asn 
1               5                   10                  15      


Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          


Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Lys 
        35                  40                  45              


Tyr Ser Glu Lys Gly Lys Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  


Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  


Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      


Glu Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         


Ile Val Gln Gln Thr Arg Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             


Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 


Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 


Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Asp Ser Met Asp Lys 
                165                 170                 175     


Glu Glu Met Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         


Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             


Lys Gln Arg Leu Asn Lys Arg Ser Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 


Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 


Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     


Ala Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         


Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             


Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 


Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 


Met Ile Thr Tyr Ile Thr Arg Asn Gln Pro Glu Trp Phe Arg Asn Val 
                325                 330                 335     


Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         


Lys Gly Tyr Met Phe Glu Ser Lys Ser Met Lys Leu Arg Thr Gln Val 
        355                 360                 365             


Pro Ala Glu Met Leu Ala Asn Ile Asp Leu Lys Tyr Phe Asn Lys Ser 
    370                 375                 380                 


Thr Arg Glu Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Asp Gly Thr 
385                 390                 395                 400 


Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     


Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Lys Tyr Thr 
            420                 425                 430         


Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             


Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 


Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 


Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     


Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         


Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Val Gly Val Thr 
        515                 520                 525             


Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 


Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 


Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ala Phe Glu Leu 
                565                 570                 575     


Lys Lys Leu Trp Glu Gln Thr Arg Ser Lys Ala Gly Leu Leu Val Ser 
            580                 585                 590         


Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             


Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Gln Gly Arg Leu 
    610                 615                 620                 


Cys Asn Pro Met Asn Pro Phe Val Ser His Lys Glu Ile Asp Ser Val 
625                 630                 635                 640 


Asn Asn Ala Val Val Met Pro Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     


Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         


Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             


Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 


Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 


Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     


Lys Glu Glu Phe Ala Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         


Leu Arg Arg Gln Lys 
        755         


<210>  42
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H7N9/PB2_1-127

<400>  42

Met Glu Arg Ile Lys Glu Leu Arg Asp Leu Met Ser Gln Ser Arg Thr 
1               5                   10                  15      


Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          


Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              


Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Met 
    50                  55                  60                  


Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  


Thr Asn Asp Ala Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      


Thr Trp Trp Asn Arg Asn Gly Pro Thr Thr Ser Thr Val His Tyr Pro 
            100                 105                 110         


Lys Val Tyr Lys Thr Tyr Phe Glu Lys Val Glu Arg Leu Lys His 
        115                 120                 125         


<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV-cleavable poly-histidine tag

<400>  43

Gly Ser Gly Ser Glu Asn Leu Tyr Phe Gln Gly Ser His His His His 
1               5                   10                  15      


His His His His 
            20  


<210>  44
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H7N9/PA full length

<400>  44

Met Glu Asp Phe Val Arg Gln Cys Phe Asn Pro Met Ile Val Glu Leu 
1               5                   10                  15      


Ala Glu Lys Ala Met Lys Glu Tyr Gly Glu Asp Pro Lys Ile Glu Thr 
            20                  25                  30          


Asn Lys Phe Ala Ser Ile Cys Thr His Leu Glu Val Cys Phe Met Tyr 
        35                  40                  45              


Ser Asp Phe His Phe Ile Asp Glu Arg Gly Glu Ser Thr Ile Ile Glu 
    50                  55                  60                  


Ser Gly Asp Pro Asn Val Leu Leu Lys His Arg Phe Glu Ile Ile Glu 
65                  70                  75                  80  


Gly Arg Asp Arg Thr Met Ala Trp Thr Val Val Asn Ser Ile Cys Asn 
                85                  90                  95      


Thr Thr Gly Val Glu Lys Pro Lys Phe Leu Pro Asp Leu Tyr Asp Tyr 
            100                 105                 110         


Lys Glu Asn Arg Phe Ile Glu Ile Gly Val Thr Arg Arg Glu Val His 
        115                 120                 125             


Ile Tyr Tyr Leu Glu Lys Ala Asn Lys Ile Lys Ser Glu Lys Thr His 
    130                 135                 140                 


Ile His Ile Phe Ser Phe Thr Gly Glu Glu Met Ala Thr Lys Ala Asp 
145                 150                 155                 160 


Tyr Thr Leu Asp Glu Glu Ser Arg Ala Arg Ile Lys Thr Arg Leu Phe 
                165                 170                 175     


Thr Ile Arg Gln Glu Met Ala Ser Arg Gly Leu Trp Asp Ser Phe Arg 
            180                 185                 190         


Gln Ser Glu Arg Gly Glu Glu Thr Ile Glu Glu Arg Phe Glu Ile Thr 
        195                 200                 205             


Gly Thr Met Arg Arg Leu Ala Asp Gln Ser Leu Pro Pro Asn Phe Ser 
    210                 215                 220                 


Ser Leu Glu Asn Phe Arg Ala Tyr Val Asp Gly Phe Glu Pro Asn Gly 
225                 230                 235                 240 


Cys Ile Glu Gly Lys Leu Ser Gln Met Ser Lys Glu Val Asn Ala Arg 
                245                 250                 255     


Ile Glu Pro Phe Leu Arg Thr Thr Pro Arg Pro Leu Arg Leu Pro Asp 
            260                 265                 270         


Gly Pro Pro Cys Ser Gln Arg Ser Lys Phe Leu Leu Met Asp Ala Leu 
        275                 280                 285             


Lys Leu Ser Ile Glu Asp Pro Ser His Glu Gly Glu Gly Ile Pro Leu 
    290                 295                 300                 


Tyr Asp Ala Ile Lys Cys Met Lys Thr Phe Phe Gly Trp Lys Glu Pro 
305                 310                 315                 320 


Asn Ile Ile Lys Pro His Glu Lys Gly Ile Asn Pro Asn Tyr Leu Leu 
                325                 330                 335     


Thr Trp Lys Gln Val Leu Ala Glu Leu Gln Asp Ile Glu Asn Glu Glu 
            340                 345                 350         


Lys Ile Pro Arg Thr Lys Asn Met Lys Lys Thr Ser Gln Leu Lys Trp 
        355                 360                 365             


Ala Leu Gly Glu Asn Met Ala Pro Glu Lys Val Asp Phe Glu Asp Cys 
    370                 375                 380                 


Lys Asp Val Asn Asp Leu Lys Gln Tyr Asp Ser Asp Glu Pro Glu Pro 
385                 390                 395                 400 


Arg Ser Leu Ala Cys Trp Ile Gln Ser Glu Phe Asn Lys Ala Cys Glu 
                405                 410                 415     


Leu Thr Asp Ser Ser Trp Val Glu Leu Asp Glu Ile Gly Glu Asp Val 
            420                 425                 430         


Ala Pro Ile Glu His Ile Ala Ser Met Arg Arg Asn Tyr Phe Thr Ala 
        435                 440                 445             


Glu Val Ser His Cys Arg Ala Thr Glu Tyr Ile Met Lys Gly Val Tyr 
    450                 455                 460                 


Ile Asn Thr Ala Leu Leu Asn Ala Ser Cys Ala Ala Met Asp Asp Phe 
465                 470                 475                 480 


Gln Leu Ile Pro Met Ile Ser Lys Cys Arg Thr Lys Glu Gly Arg Arg 
                485                 490                 495     


Lys Thr Asn Leu Tyr Gly Phe Ile Ile Lys Gly Arg Ser His Leu Arg 
            500                 505                 510         


Asn Asp Thr Asp Val Val Asn Phe Val Ser Met Glu Phe Ser Leu Thr 
        515                 520                 525             


Asp Pro Arg Leu Glu Pro His Lys Trp Glu Lys Tyr Cys Val Leu Glu 
    530                 535                 540                 


Ile Gly Asp Met Leu Leu Arg Thr Ala Val Gly Gln Val Ser Arg Pro 
545                 550                 555                 560 


Met Phe Leu Tyr Val Arg Thr Asn Gly Thr Ser Lys Ile Lys Met Lys 
                565                 570                 575     


Trp Gly Met Glu Met Arg Arg Cys Leu Leu Gln Ser Leu Gln Gln Ile 
            580                 585                 590         


Glu Ser Met Ile Glu Ala Glu Ser Ser Val Lys Glu Lys Asp Leu Thr 
        595                 600                 605             


Lys Glu Phe Phe Glu Asn Lys Ser Glu Thr Trp Pro Ile Gly Glu Ser 
    610                 615                 620                 


Pro Lys Gly Val Glu Glu Gly Ser Ile Gly Lys Val Cys Arg Thr Leu 
625                 630                 635                 640 


Leu Ala Lys Ser Val Phe Asn Ser Leu Tyr Ala Ser Pro Gln Leu Glu 
                645                 650                 655     


Gly Phe Ser Ala Glu Ser Arg Lys Leu Leu Leu Ile Val Gln Ala Leu 
            660                 665                 670         


Arg Asp Asn Leu Glu Pro Gly Thr Phe Asp Leu Glu Gly Leu Tyr Glu 
        675                 680                 685             


Ala Ile Glu Glu Cys Leu Ile Asn Asp Pro Trp Val Leu Leu Asn Ala 
    690                 695                 700                 


Ser Trp Phe Asn Ser Phe Leu Thr His Ala Leu Arg 
705                 710                 715     


<210>  45
<211>  12
<212>  RNA
<213>  Influenza A virus

<400>  45
aguaguaaca ag                                                           12


