                         SEQUENCE LISTING

<110>  Inserm
 
<120>  GENOMIC SEQUENCES ENCODING FOR AN ATTENUATED MUTANT ZIKA VIRUS

<130>  BIO16263 GADEA / MC

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  10727
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Genomic sequence of parental ZIKVBR15-MC BeH819015 (10,727 nt)

<400>  1
tgtgaatcag actgcgacag ttcgagtttg aagcgaaagc tagcaacagt atcaacaggt       60

tttattttgg atttggaaac gagagtttct ggtcatgaaa aacccaaaaa agaaatccgg      120

aggattccgg attgtcaata tgctaaaacg cggagtagcc cgtgtgagcc cctttggggg      180

cttgaagagg ctgccagccg gacttctgct gggtcatggg cccatcagga tggtcttggc      240

gattctagcc tttttgagat tcacggcaat caagccatca ctgggtctca tcaatagatg      300

gggttcagtt gggaaaaaag aggctatgga aataataaag aagttcaaga aagatctggc      360

tgccatgctg agaataatca atgctaggaa ggagaagaag agacgaggcg cagatactag      420

tgtcggaatt gttggcctcc tgctgaccac agctatggca gcggaggtca ctagacgtgg      480

gagtgcatac tatatgtact tggacagaaa cgatgctggg gaggccatat cttttccaac      540

cacattgggg atgaataagt gttatataca gatcatggat cttggacaca tgtgtgatgc      600

caccatgagc tatgaatgcc ctatgctgga tgagggggtg gaaccagatg acgtcgattg      660

ttggtgcaac acgacgtcaa cttgggttgt gtacggaacc tgccatcaca aaaaaggtga      720

agcacggaga tctagaagag ctgtgacgct cccctcccat tccactagga agctgcaaac      780

gcggtcgcaa acctggttgg aatcaagaga atacacaaag cacttgatta gagtcgaaaa      840

ttggatattc aggaaccctg gcttcgcgtt agcagcagct gccatcgctt ggcttttggg      900

aagctcaacg agccaaaaag tcatatactt ggtcatgata ctgctgattg ccccggcata      960

cagcatcagg tgcataggag tcagcaatag ggactttgtg gaaggtatgt caggtgggac     1020

ttgggttgat gttgtcttgg aacatggagg ttgtgtcacc gtaatggcac aggacaaacc     1080

gactgtcgac atagagctgg ttacaacaac agtcagcaac atggcggagg taagatccta     1140

ctgctatgag gcatcaatat cagacatggc ttcggacagc cgctgcccaa cacaaggtga     1200

agcctacctt gacaagcaat cagacactca atatgtctgc aaaagaacgt tagtggacag     1260

aggctgggga aatggatgtg gactttttgg caaagggagc ctggtgacat gcgctaagtt     1320

tgcatgctcc aagaaaatga ccgggaagag catccagcca gagaatctgg agtaccggat     1380

aatgctgtca gttcatggct cccagcacag tgggatgatc gttaatgaca caggacatga     1440

aactgatgag aatagagcga aagttgagat aacgcccaat tcaccaagag ccgaagccac     1500

cctggggggt tttggaagcc taggacttga ttgtgaaccg aggacaggcc ttgacttttc     1560

agatttgtat tacttgacta tgaataacaa gcactggttg gttcacaagg agtggttcca     1620

cgacattcca ttaccttggc acgctggggc agacaccgga actccacact ggaacaacaa     1680

agaagcactg gtagagttca aggacgcaca tgccaaaagg caaactgtcg tggttctagg     1740

gagtcaagaa ggagcagttc acacggccct tgctggagct ctggaggctg agatggatgg     1800

tgcaaaggga aggctgtcct ctggccactt gaaatgtcgc ctgaaaatgg ataaacttag     1860

attgaagggc gtgtcatact ccttgtgtac tgcagcgttc acattcacca agatcccggc     1920

tgaaacactg cacgggacag tcacagtgga ggtacagtac gcagggacag atggaccttg     1980

caaggttcca gctcagatgg cggtggacat gcaaactctg accccagttg ggaggttgat     2040

aaccgctaac cccgtaatca ctgaaagcac tgagaactct aagatgatgc tggaacttga     2100

tccaccattt ggggactctt acattgtcat aggagtcggg gagaagaaga tcacccacca     2160

ctggcacagg agtggcagca ccattggaaa agcatttgaa gccactgtga gaggtgccaa     2220

gagaatggca gtcttgggag acacagcctg ggactttgga tcagttggag gcgctctcaa     2280

ctcattgggc aagggcatcc atcaaatttt tggagcagct ttcaaatcat tgtttggagg     2340

aatgtcctgg ttctcacaaa ttctcattgg aacgttgctg atgtggttgg gtctgaacac     2400

aaagaatgga tctatttccc ttatgtgctt ggccttaggg ggggtgttga tcttcttatc     2460

cacagccgtc tctgctgatg tggggtgctc ggtggacttc tcaaagaagg agacgagatg     2520

cggtacaggg gtgttcgtct ataacgacgt tgaagcctgg agggacaggt acaagtacca     2580

tcctgactcc ccccgtagat tggcagcagc agtcaagcaa gcctgggaag atggtatctg     2640

cgggatctcc tctgtttcaa gaatggaaaa catcatgtgg agatcagtag aaggggagct     2700

caacgcaatc ctggaagaga atggagttca actgacggtc gttgtgggat ctgtaaaaaa     2760

ccccatgtgg agaggtccac agagattgcc cgtgcctgtg aacgagctgc cccacggctg     2820

gaaggcttgg gggaaatcgt acttcgtcag agcagcaaag acaaataaca gctttgtcgt     2880

ggatggtgac acactgaagg aatgcccact caaacataga gcatggaaca gctttcttgt     2940

ggaggatcat gggttcgggg tatttcacac tagtgtctgg ctcaaggtta gagaagatta     3000

ttcattagag tgtgatccag ccgttattgg aacagctgtt aagggaaagg aggctgtaca     3060

cagtgatcta ggctactgga ttgagagtga gaagaatgac acatggaggc tgaagagggc     3120

ccatctgatc gagatgaaaa catgtgaatg gccaaagtcc cacacattgt ggacagatgg     3180

aatagaagag agtgatctga tcatacccaa gtctttagct gggccactca gccatcacaa     3240

taccagagag ggctacagga cccaaatgaa agggccatgg cacagtgaag agcttgaaat     3300

tcggtttgag gaatgcccag gcactaaggt ccacgtggag gaaacatgtg gaacaagagg     3360

accatctctg agatcaacca ctgcaagcgg aagggtgatc gaggaatggt gctgcaggga     3420

gtgcacaatg cccccactgt cgttccgggc taaagatggc tgttggtatg gaatggagat     3480

aaggcccagg aaagaaccag aaagcaactt agtaaggtca atggtgactg caggatcaac     3540

tgatcacatg gaccacttct cccttggagt gcttgtgatc ctgctcatgg tgcaggaagg     3600

gctgaagaag agaatgacca caaagatcat cataagcaca tcaatggcag tgctggtagc     3660

tatgatcctg ggaggatttt caatgagtga cctggctaag cttgcaattt tgatgggtgc     3720

caccttcgcg gaaatgaaca ctggaggaga tgtagctcat ctggcgctga tagcggcatt     3780

caaagtcaga ccagcgttgc tggtatcttt catcttcaga gctaattgga caccccgtga     3840

aagcatgctg ctggccttgg cctcgtgtct tttgcaaact gcgatctccg ccttggaagg     3900

cgacctgatg gttctcatca atggttttgc tttggcctgg ttggcaatac gagcgatggt     3960

tgttccacgc actgataaca tcaccttggc aatcctggct gctctgacac cactggcccg     4020

gggcacactg cttgtggcgt ggagagcagg ccttgctact tgcggggggt ttatgctcct     4080

ctctctgaag ggaaaaggca gtgtgaagaa gaacttacca tttgtcatgg ccctgggact     4140

aaccgctgtg aggctggtcg accccatcaa cgtggtggga ctgctgttac tcacaaggag     4200

tgggaagcgg agctggcccc ctagcgaagt actcacagct gttggcctga tatgcgcatt     4260

ggctggaggg ttcgccaagg cagatataga gatggctggg cccatggccg cggtcggtct     4320

gctaattgtc agttacgtgg tctcaggaaa gagtgtggac atgtacattg aaagagcagg     4380

tgacatcaca tgggaaaaag atgcggaagt cactggaaac agtccccggc tcgatgtggc     4440

gctagatgag agtggtgatt tctccctggt ggaggatgac ggtcccccca tgagagagat     4500

catactcaag gtggtcctga tgaccatctg tggcatgaat ccaatagcca taccctttgc     4560

agctggagcg tggtacgtat acgtgaagac tggaaaaagg agtggtgctc tatgggatgt     4620

gcctgctccc aaggaagtaa aaaaggggga gaccacagat ggagtgtaca gagtaatgac     4680

tcgtagactg ctaggttcaa cacaagttgg agtgggagtt atgcaagagg gggtctttca     4740

cactatgtgg cacgtcacaa aaggatccgc gctgagaagc ggtgaaggga gacttgatcc     4800

atactgggga gatgtcaagc aggatctggt gtcatactgt ggtccatgga agctagatgc     4860

cgcctgggac gggcacagcg aggtgcagct cttggccgtg ccccccggag agagagcgag     4920

gaacatccag actctgcccg gaatatttaa gacaaaggat ggggacattg gagcggttgc     4980

gctggattac ccagcaggaa cttcaggatc tccaatccta gacaagtgtg ggagagtgat     5040

aggactttat ggcaatgggg tcgtgatcaa aaatgggagt tatgttagtg ccatcaccca     5100

agggaggagg gaagaagaga ctcctgttga gtgcttcgag ccctcgatgc tgaagaagaa     5160

gcagctaact gtcttagact tgcatcctgg agctgggaaa accaggagag ttcttcctga     5220

aatagtccgt gaagccataa aaacaagact ccgtactgtg atcttagctc caaccagggt     5280

tgtcgctgct gaaatggagg aggcccttag agggcttcca gtgcgttata tgacaacagc     5340

agtcaatgtc acccactctg gaacagaaat cgtcgactta atgtgccatg ccaccttcac     5400

ttcacgtcta ctacagccaa tcagagtccc caactataat ctgtatatta tggatgaggc     5460

ccacttcaca gatccctcaa gtatagcagc aagaggatac atttcaacaa gggttgagat     5520

gggcgaggcg gctgccatct tcatgaccgc cacgccacca ggaacccgtg acgcatttcc     5580

ggactccaac tcaccaatta tggacaccga agtggaagtc ccagagagag cctggagctc     5640

aggctttgat tgggtgacgg atcattctgg aaaaacagtt tggtttgttc caagcgtgag     5700

gaacggcaat gagatcgcag cttgtctgac aaaggctgga aaacgggtca tacagctcag     5760

cagaaagact tttgagacag agttccagaa aacaaaacat caagagtggg actttgtcgt     5820

gacaactgac atttcagaga tgggcgccaa ctttaaagct gaccgtgtca tagattccag     5880

gagatgccta aagccggtca tacttgatgg cgagagagtc attctggctg gacccatgcc     5940

tgtcacacat gccagcgctg cccagaggag ggggcgcata ggcaggaatc ccaacaaacc     6000

tggagatgag tatctgtatg gaggtgggtg cgcagagact gacgaagacc atgcacactg     6060

gcttgaagca agaatgctcc ttgacaatat ttacctccaa gatggcctca tagcctcgct     6120

ctatcgacct gaggccgaca aagtagcagc cattgaggga gagttcaagc ttaggacgga     6180

gcaaaggaag acctttgtgg aactcatgaa aagaggagat cttcctgttt ggctggccta     6240

tcaggttgca tctgccggaa taacctacac agatagaaga tggtgctttg atggcacgac     6300

caacaacacc ataatggaag atagtgtgcc ggcagaggtg tggaccagac acggagagaa     6360

aagagtgctc aaaccgaggt ggatggacgc cagagtttgt tcagatcatg cggccctgaa     6420

gtcattcaag gagtttgccg ctgggaaaag aggagcggct tttggagtga tggaagccct     6480

gggaacactg ccaggacaca tgacagagag attccaggaa gccattgaca acctcgctgt     6540

gctcatgcgg gcagagactg gaagcaggcc ttacaaagcc gcggcggccc aattgccgga     6600

gaccctagag accataatgc ttttggggtt gctgggaaca gtctcgctgg gaatcttctt     6660

cgtcttgatg aggaacaagg gcatagggaa gatgggcttt ggaatggtga ctcttggggc     6720

cagcgcatgg ctcatgtggc tctcggaaat tgagccagcc agaattgcat gtgtcctcat     6780

tgttgtgttc ctattgctgg tggtgctcat acctgagcca gaaaagcaaa gatctcccca     6840

ggacaaccaa atggcaatca tcatcatggt agcagtaggt cttctgggct tgattaccgc     6900

caatgaactc ggatggttgg agagaacaaa gagtgaccta agccatctaa tgggaaggag     6960

agaggagggg gcaaccatag gattctcaat ggacattgac ctgcggccag cctcagcttg     7020

ggccatctat gctgccttga caactttcat taccccagcc gtccaacatg cagtgaccac     7080

ctcatacaac aactactcct taatggcgat ggccacgcaa gctggagtgt tgtttggtat     7140

gggcaaaggg atgccattct acgcatggga ctttggagtc ccgctgctaa tgataggttg     7200

ctactcacaa ttaacacccc tgaccctaat agtggccatc attttgctcg tggcgcacta     7260

catgtacttg atcccagggc tgcaggcagc agctgcgcgt gctgcccaga agagaacggc     7320

agctggcatc atgaagaacc ctgttgtgga tggaatagtg gtgactgaca ttgacacaat     7380

gacaattgac ccccaagtgg agaaaaagat gggacaggtg ctactcatag cagtagccgt     7440

ctccagcgcc atactgtcgc ggaccgcctg ggggtggggg gaggctgggg ccctgatcac     7500

agccgcaact tccactttgt gggaaggctc tccgaacaag tactggaact cctctacagc     7560

cacttcactg tgtaacattt ttaggggaag ttacttggct ggagcttctc taatctacac     7620

agtaacaaga aacgctggct tggtcaagag acgtgggggt ggaacaggag agaccctggg     7680

agagaaatgg aaggcccgct tgaaccagat gtcggccctg gagttctact cctacaaaaa     7740

gtcaggcatc accgaggtgt gcagagaaga ggcccgccgc gccctcaagg acggtgtggc     7800

aacgggaggc catgctgtgt cccgaggaag tgcaaagctg agatggttgg tggagcgggg     7860

atacctgcag ccctatggaa aggtcattga tcttggatgt ggcagagggg gctggagtta     7920

ctacgccgcc accatccgca aagttcaaga agtgaaagga tacacaaaag gaggccctgg     7980

tcatgaagaa cccgtgttgg tgcaaagcta tgggtggaac atagtccgtc ttaagagtgg     8040

ggtggacgtc tttcatatgg cggctgagcc gtgtgacacg ctgctgtgtg acataggtga     8100

gtcatcatct agtcctgaag tggaagaagc acggacgctc agagtcctct ccatggtggg     8160

ggattggctt gaaaaaagac caggagcctt ttgtataaaa gtgttgtgcc catacaccag     8220

cactatgatg gaaaccctgg agcgactgca gcgtaggtat gggggaggac tggtcagagt     8280

gccactctcc cgcaactcta cacatgagat gtactgggtc tctggagcga aaagcaacac     8340

cataaaaagt gtgtccacca cgagccagct cctcttgggg cgcatggacg ggcctaggag     8400

gccagtgaaa tatgaggagg atgtgaatct cggctctggc acgcgggctg tggtaagctg     8460

cgctgaagct cccaacatga agatcattgg taaccgcatt gaaaggatcc gcagtgagca     8520

cgcggaaacg tggttctttg acgagaacca cccatatagg acatgggctt accatggaag     8580

ctatgaggcc cccacacaag ggtcagcgtc ctctctaata aacggggttg tcaggctcct     8640

gtcaaaaccc tgggatgtgg tgactggagt cacaggaata gccatgaccg acaccacacc     8700

gtatggtcag caaagagttt tcaaggaaaa agtggacact agggtgccag acccccaaga     8760

aggcactcgt caggttatga gcatggtctc ttcctggttg tggaaagagc taggcaaaca     8820

caaacggcca cgagtctgta ccaaagaaga gttcatcaac aaggttcgta gcaatgcagc     8880

attaggggca atatttgaag aggaaaaaga gtggaagact gcagtggaag ctgtgaacga     8940

tccaaggttc tgggctctag tggacaagga aagagagcac cacctgagag gagagtgcca     9000

gagttgtgtg tataacatga tgggaaaaag agaaaagaaa caaggggaat ttggaaaggc     9060

caagggcagc cgcgccatct ggtatatgtg gctaggggct agatttctag agttcgaagc     9120

ccttggattc ttgaacgagg atcactggat ggggagagag aactcaggag gtggtgttga     9180

agggctggga ttacaaagac tcggatatgt cctagaagag atgagtcgta taccaggagg     9240

aaggatgtat gcagatgaca ctgctggctg ggacacccgc attagcaggt ttgatctgga     9300

gaatgaagct ctaatcacca accaaatgga gaaagggcac agggccttgg cattggccat     9360

aatcaagtac acataccaaa acaaagtggt aaaggtcctt agaccagctg aaaaagggaa     9420

aacagttatg gacattattt cgagacaaga ccaaaggggg agcggacaag ttgtcactta     9480

cgctcttaac acatttacca acctagtggt gcaactcatt cggaatatgg aggctgagga     9540

agttctagag atgcaagact tgtggctgct gcggaggtca gagaaagtga ccaactggtt     9600

gcagagcaac ggatgggata ggctcaaacg aatggcagtc agtggagatg attgcgttgt     9660

gaagccaatt gatgataggt ttgcacatgc cctcaggttc ttgaatgata tgggaaaagt     9720

tagaaaggac acacaagagt ggaaaccctc aactggatgg gacaactggg aagaagttcc     9780

gttttgctcc caccacttca acaagctcca tctcaaggac gggaggtcca ttgtggttcc     9840

ctgccgccac caagatgaac tgattggccg ggcccgcgtc tctccagggg cgggatggag     9900

catccgggag actgcttgcc tagcaaaatc atatgcgcag atgtggcagc tcctttattt     9960

ccacagaagg gacctccgac tgatggccaa tgccatttgt tcatctgtgc cagttgactg    10020

ggttccaact gggagaacta cctggtcaat ccatggaaag ggagaatgga tgaccactga    10080

agacatgctt gtggtgtgga acagagtgtg gattgaggag aacgaccaca tggaagacaa    10140

gaccccagtt acgaaatgga cagacattcc ctatttggga aaaagggaag acttgtggtg    10200

tggatctctc atagggcaca gaccgcgcac cacctgggct gagaacatta aaaacacagt    10260

caacatggtg cgcaggatca taggtgatga agaaaagtac atggactacc tatccaccca    10320

agttcgctac ttgggtgaag aagggtctac acctggagtg ctgtaagcac caatcttaat    10380

gttgtcaggc ctgctagtca gccacagctt ggggaaagct gtgcagcctg tgacccccca    10440

ggagaagctg ggaaaccaag cctatagtca ggccgagaac gccatggcac ggaagaagcc    10500

atgctgcctg tgagcccctc agaggatact gagtcaaaaa accccacgcg cttggaggcg    10560

caggatggga aaagaaggtg gcgaccttcc ccacccttca atctggggcc tgaactggag    10620

atcagctgtg gatccccaga agagggacta gtggttagag gagacccccc ggaaaacgca    10680

aaacagcata ttgacgctgg gaaagaccag agactccatg agtttcc                  10727


<210>  2
<211>  10807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Genomic sequence of chimeric ZIKVBR15-MC mutant miR4279 (10,807 
       nt)

<400>  2
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac       60

agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa      120

aaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtgag      180

cccctttggg ggcttgaaga ggctgccagc cggacttctg ctgggtcatg ggcccatcag      240

gatggtcttg gcgattctag cctttttgag attcacggca atcaagccat cactgggtct      300

catcaataga tggggttcag ttgggaaaaa agaggctatg gaaataataa agaagttcaa      360

gaaagatctg gctgccatgc tgagaataat caatgctagg aaggagaaga agagacgagg      420

cgcagatact agtgtcggaa ttgttggcct cctgctgacc acagctatgg cagcggaggt      480

cactagacgt gggagtgcat actatatgta cttggacaga aacgatgctg gggaggccat      540

atcttttcca accacattgg ggatgaataa gtgttatata cagatcatgg atcttggaca      600

catgtgtgat gccaccatga gctatgaatg ccctatgctg gatgaggggg tggaaccaga      660

tgacgtcgat tgttggtgca acacgacgtc aacttgggtt gtgtacggaa cctgccatca      720

caaaaaaggt gaagcacgga gatctagaag agctgtgacg ctcccctccc attccactag      780

gaagctgcaa acgcggtcgc aaacctggtt ggaatcaaga gaatacacaa agcacttgat      840

tagagtcgaa aattggatat tcaggaaccc tggcttcgcg ttagcagcag ctgccatcgc      900

ttggcttttg ggaagctcaa cgagccaaaa agtcatatac ttggtcatga tactgctgat      960

tgccccggca tacagcatca ggtgcatagg agtcagcaat agggactttg tggaaggtat     1020

gtcaggtggg acttgggttg atgttgtctt ggaacatgga ggttgtgtca ccgtaatggc     1080

acaggacaaa ccgactgtcg acatagagct ggttacaaca acagtcagca acatggcgga     1140

ggtacgatcg tactgctatg aggcatcaat atcagacatg gcttcggaca gccgctgccc     1200

aacacaaggt gaagcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac     1260

gttagtggac agaggctggg gaaatggatg tggacttttt ggcaaaggga gcctggtgac     1320

atgcgctaag tttgcatgct ccaagaaaat gaccgggaag agcatccagc cagagaatct     1380

ggagtaccgg ataatgctgt cagttcatgg ctcccagcac agtgggatga tcgttaatga     1440

cacaggacat gaaactgatg agaatagagc gaaagttgag ataacgccca attcaccaag     1500

agccgaagcc accctggggg gttttggaag cctaggactt gattgtgaac cgaggacagg     1560

ccttgacttt tcagatttgt attacttgac tatgaataac aagcactggt tggttcacaa     1620

ggagtggttc cacgacattc cattaccttg gcacgctggg gcagacaccg gaactccaca     1680

ctggaacaac aaagaagcac tggtagagtt caaggacgca catgccaaaa ggcaaactgt     1740

cgtggttcta gggagtcaag aaggagcagt tcacacggcc cttgctggag ctctggaggc     1800

tgagatggat ggtgcaaagg gaaggctgtc ctctggccac ttgaaatgtc gcctgaaaat     1860

ggataaactt agattgaagg gcgtgtcata ctccttgtgt actgcagcgt tcacattcac     1920

caagatcccg gctgaaacac tgcacgggac agtcacagtg gaggtacagt acgcagggac     1980

agatggacct tgcaaggttc cagctcagat ggcggtggac atgcaaactc tgaccccagt     2040

tgggaggttg ataaccgcta accccgtaat cactgaaagc actgagaact ctaagatgat     2100

gctggaactt gatccaccat ttggggactc ttacattgtc ataggagtcg gggagaagaa     2160

gatcacccac cactggcaca ggagtggcag caccattgga aaagcatttg aggccactgt     2220

gagaggcgcc aagagaatgg cagtcctggg ggacacagcc tgggactttg gatcagttgg     2280

aggcgctctc aactcattgg gcaagggcat ccatcaaatt tttggagcag ctttcaaatc     2340

attgtttgga ggaatgtcct ggttctcaca aattctcatt ggaacgttgc tgatgtggtt     2400

gggtctgaac acaaagaatg gatctatttc ccttatgtgc ttggccttag ggggggtgtt     2460

gatcttctta tccacagccg tctctgctga tgtggggtgc tcggtggact tctcaaagaa     2520

ggagacgaga tgcggtacag gggtgttcgt ctataacgac gttgaagcct ggagggacag     2580

gtacaagtac catcctgact ccccccgtag attggcagca gcagtcaagc aagcctggga     2640

agatggtatc tgcgggatct cctctgtttc aagaatggaa aacatcatgt ggagatcagt     2700

agaaggggag ctcaacgcta tcctagagga gaatggagtt caactgacgg tcgttgtggg     2760

atctgtaaaa aaccccatgt ggagaggtcc acagagattg cccgtgcctg tgaacgagct     2820

gccccacggc tggaaggctt gggggaaatc gtacttcgtc agagcagcaa agacaaataa     2880

cagctttgtc gtggatggtg acacactgaa ggaatgccca ctcaaacata gagcatggaa     2940

cagctttctt gtggaggatc atgggttcgg ggtatttcac actagtgtct ggctcaaggt     3000

tagagaagat tattcattag agtgtgatcc agccgttatt ggaacagctg ttaagggaaa     3060

ggaggctgta cacagtgatc taggctactg gattgagagt gagaagaatg acacatggag     3120

gctgaagagg gcccatctga tcgagatgaa aacatgtgaa tggccaaagt cccacacatt     3180

gtggacagat ggaatagaag agagtgatct gatcataccc aagtctttag ctgggccact     3240

cagccatcac aataccagag agggctacag gacccaaatg aaagggccat ggcacagtga     3300

agagcttgaa attcggtttg aggaatgccc aggcactaag gtttacgtgg aggagacatg     3360

tggaacaaga ggaccatctc tgagatcaac cactgcaagc ggaagggtga tcgaggaatg     3420

gtgctgcagg gagtgcacaa tgcccccact gtcgttccgg gctaaagatg gctgttggta     3480

tggaatggag ataaggccca ggaaagaacc agaaagcaac ttagtaaggt caatggtgac     3540

tgcaggatca actgatcaca tggaccactt ctcccttgga gtgcttgtga tcctgctcat     3600

ggtgcaggaa gggctgaaga agagaatgac cacaaagatc atcataagca catcaatggc     3660

agtgctggta gctatgatcc tgggaggatt ttcaatgagt gacctggcta agcttgcaat     3720

tttgatgggt gccaccttcg cggaaatgaa cactggagga gatgtagctc atctggcgct     3780

gatagcggca ttcaaagtca gaccagcgtt gctggtatct ttcatcttca gagctaattg     3840

gacaccccgt gaaagcatgc tgctggcctt ggcctcgtgt cttttgcaaa ctgcgatctc     3900

cgccttggaa ggcgacctga tggttctcat caatggtttt gctttggcct ggttggcaat     3960

acgagcgatg gttgttccac gcactgataa catcaccttg gcaatcctgg ctgctctgac     4020

accactggcc cggggcacac tgcttgtggc gtggagagca ggccttgcta cttgcggggg     4080

gtttatgctc ctctctctga agggaaaagg cagtgtgaag aagaacttac catttgtcat     4140

ggccctggga ctaaccgctg tgaggctggt cgaccccatc aacgtggtgg gactgctgtt     4200

actcacaagg agtgggaagc ggagctggcc ccctagcgaa gtactcacag ctgttggcct     4260

gatatgcgca ttggctggag ggttcgccaa ggcagatata gagatggctg ggcccatggc     4320

cgcggtcggt ctgctaattg tcagttacgt ggtctcagga aagagtgtgg acatgtacat     4380

tgaaagagca ggtgacatca catgggaaaa agatgcggaa gtcactggaa acagtccccg     4440

gctcgatgtg gcgctagatg agagtggtga tttctccctg gtggaggatg acggtccccc     4500

catgagagag atcatactca aggtggtcct gatgaccatc tgtggcatga atccaatagc     4560

catacccttt gcagctggag cgtggtacgt atacgtgaag actggaaaaa ggagtggtgc     4620

tctatgggat gtgcctgctc ccaaggaagt aaaaaagggg gagaccacag atggagtgta     4680

cagagtaatg actcgtagac tgctaggttc aacacaagtt ggagtgggag ttatgcaaga     4740

gggggtcttt cacactatgt ggcacgtcac aaaaggatcc gcgctgagaa gcggtgaagg     4800

gagacttgat ccatactggg gagatgtcaa gcaggatctg gtgtcatact gtggtccatg     4860

gaagctagat gccgcctggg acgggcacag cgaggtgcag ctcttggccg tgccccccgg     4920

agagagagcg aggaacatcc agactctgcc cggaatattt aagacaaagg atggggacat     4980

tggagcggtt gcgctggatt acccagcagg aacttcagga tctccaatcc tagacaagtg     5040

tgggagagtg ataggacttt atggcaatgg ggtcgtgatc aaaaatggga gttatgttag     5100

tgccatcacc caagggaaga gggaggagga gactcctgtt gagtgcttcg agccctcgat     5160

gctgaagaag aagcagctaa ctgtcttaga cttgcatcct ggagctggga aaaccaggag     5220

agttcttcct gaaatagtcc gtgaagccat aaaaacaaga ctccgtactg tgatcttagc     5280

tccaaccagg gttgtcgctg ctgaaatgga ggaggccctt agagggcttc cagtgcgtta     5340

tatgacaaca gcagtcaatg tcacccactc tggaacagaa atcgtcgact taatgtgcca     5400

tgccaccttc acttcacgtc tactacagcc aatcagagtc cccaactata atctgtatat     5460

tatggatgag gcccacttca cagatccctc aagtatagca gcaagaggat acatttcaac     5520

aagggttgag atgggcgagg cggctgccat cttcatgacc gccacgccac caggaacccg     5580

tgacgcattt ccggactcca actcaccaat tatggacacc gaagtggaag tcccagagag     5640

agcctggagc tcaggctttg attgggtgac ggatcattct ggaaaaacag tttggtttgt     5700

tccaagcgtg aggaacggca atgagatcgc agcttgtctg acaaaggctg gaaaacgggt     5760

catacagctc agcagaaaga cttttgagac agagttccag aaaacaaaac atcaagagtg     5820

ggactttgtc gtgacaactg acatttcaga gatgggcgcc aactttaaag ctgaccgtgt     5880

catagattcc aggagatgcc taaagccggt catacttgat ggcgagagag tcattctggc     5940

tggacccatg cctgtcacac atgccagcgc tgctcagagg agagggcgca taggcaggaa     6000

tcccaacaaa cctggagatg agtatctgta tggaggtggg tgcgcagaga ctgacgaaga     6060

ccatgcacac tggcttgaag caagaatgct ccttgacaat atttacctcc aagatggcct     6120

catagcctcg ctctatcgac ctgaggccga caaagtagca gccattgagg gagagttcaa     6180

gcttaggacg gagcaaagga agacctttgt ggaactcatg aagagaggag accttcctgt     6240

ttggctggcc tatcaggttg catctgccgg aataacctac acagatagaa gatggtgctt     6300

tgatggcacg accaacaaca ccataatgga agatagtgtg ccggcagagg tgtggaccag     6360

acacggagag aaaagagtgc tcaaaccgag gtggatggac gccagagttt gttcagatca     6420

tgcggccctg aagtcattca aggagtttgc cgctgggaaa agaggagcgg cttttggagt     6480

gatggaagcc ctgggaacac tgccaggaca catgacagag agattccagg aagccattga     6540

caacctcgct gtgctcatgc gggcagagac tggaagcagg ccttacaaag ccgcggcggc     6600

ccaattgccg gagaccctag agaccataat gcttttgggg ttgctgggaa cagtctcgct     6660

gggaatcttc ttcgtcttga tgaggaacaa gggcataggg aagatgggct ttggaatggt     6720

gactcttggg gccagcgcat ggctcatgtg gctctcggaa attgagccag ccagaattgc     6780

atgtgtcctc attgttgtgt tcctattgct ggtggtgctc atacctgagc cagaaaagca     6840

aagatctccc caggacaacc aaatggcaat catcatcatg gtagcagtag gtcttctggg     6900

cttgattacc gccaatgaac tcggatggtt ggagagaaca aagagtgacc taagccatct     6960

aatgggaagg agagaggagg gggcaaccat aggattctca atggacattg acctgcggcc     7020

agcctcagct tgggccatct atgctgcctt gacaactttc attaccccag ccgtccaaca     7080

tgcagtgacc acttcataca acaactactc cttaatggcg atggccacgc aagctggagt     7140

gttgtttggt atgggcaaag ggatgccatt ctacgcatgg gactttggag tcccgctgct     7200

aatgataggt tgctactcac aattaacacc cctgacccta atagtggcca tcattttgct     7260

cgtggcgcac tacatgtact tgatcccagg gctgcaggca gcagctgcgc gtgctgccca     7320

gaagagaacg gcagctggca tcatgaagaa ccctgttgtg gatggaatag tggtgactga     7380

cattgacaca atgacaattg acccccaagt ggagaaaaag atgggacagg tgctactcat     7440

agcagtagcc gtctccagcg ccatactgtc gcggaccgcc tgggggtggg gggaggctgg     7500

ggccctgatc acagccgcaa cttccacttt gtgggaaggc tctccgaaca agtactggaa     7560

ctcctctaca gccacttcac tgtgtaacat ttttagggga agttacttgg ctggagcttc     7620

tctaatctac acagtaacaa gaaacgctgg cttggtcaag agacgtgggg gtggaacagg     7680

agagaccctg ggagagaaat ggaaggcccg cttgaaccag atgtcggccc tggagttcta     7740

ctcctacaaa aagtcaggca tcaccgaggt gtgcagagaa gaggcccgcc gcgccctcaa     7800

ggacggtgtg gcaacgggag gccatgctgt gtcccgagga agtgcaaagc tgagatggtt     7860

ggtggagcgg ggatacctgc agccctatgg aaaggtcatt gatcttggat gtggcagagg     7920

gggctggagt tactacgccg ccaccatccg caaagttcaa gaagtgaaag gatacacaaa     7980

aggaggccct ggtcatgaag aacccgtgtt ggtgcaaagc tatgggtgga acatagtccg     8040

tcttaagagt ggggtggacg tctttcatat ggcggctgag ccgtgtgaca cgctgctgtg     8100

tgacataggt gagtcatcat ctagtcctga agtggaagaa gcacggacgc tcagagtcct     8160

ctccatggtg ggggattggc ttgaaaaaag accaggagcc ttttgtataa aagtgttgtg     8220

cccatacacc agcactatga tggaaaccct ggagcgactg cagcgtaggt atgggggagg     8280

actggtcaga gtgccactct cccgcaactc tacacatgag atgtactggg tctctggagc     8340

gaaaagcaac accataaaaa gtgtgtccac cacgagccag ctcctcttgg ggcgcatgga     8400

cgggcctagg aggccagtga aatatgagga ggatgtgaat ctcggctctg gcacgcgggc     8460

tgtggtaagc tgcgctgaag ctcccaacat gaagatcatt ggtaaccgca ttgaaaggat     8520

ccgcagtgag cacgcggaaa cgtggttctt tgacgagaac cacccatata ggacatgggc     8580

ttaccatgga agctatgagg cccccacaca agggtcagcg tcctctctaa taaacggggt     8640

tgtcaggctc ctgtcaaaac cctgggatgt ggtgactgga gtcacaggaa tagccatgac     8700

cgacaccaca ccgtatggtc agcaaagagt tttcaaggaa aaagtggaca ctagggtgcc     8760

agacccccaa gaaggcactc gtcaggttat gagcatggtc tcttcctggt tgtggaaaga     8820

gctaggcaaa cacaaacggc cacgagtctg taccaaagaa gagttcatca acaaggttcg     8880

tagcaatgca gcattagggg caatatttga agaggaaaaa gagtggaaga ctgcagtgga     8940

agctgtgaac gatccaaggt tctgggctct agtggacaag gaaagagagc accacctgag     9000

aggagagtgc cagagttgtg tgtataacat gatgggaaaa agagaaaaga aacaagggga     9060

atttggaaag gccaagggca gccgcgccat ctggtatatg tggctagggg ctagatttct     9120

agagttcgaa gcccttggat tcttgaacga ggatcactgg atggggagag agaactcagg     9180

aggtggtgtt gaagggctgg gattacaaag actcggatat gtcctagaag agatgagtcg     9240

tataccagga ggaaggatgt atgcagatga cactgctggc tgggacaccc gcattagcag     9300

gtttgatctg gagaatgaag ctctaatcac caaccaaatg gagaaagggc acagggcctt     9360

ggcattggcc ataatcaagt acacatacca aaacaaagtg gtaaaggtcc ttagaccagc     9420

tgaaaaaggg aaaacagtta tggacattat ttcgagacaa gaccaaaggg ggagcggaca     9480

agttgtcact tacgctctta acacatttac caacctagtg gtgcaactca ttcggaatat     9540

ggaggctgag gaagttctag agatgcaaga cttgtggctg ctgcggaggt cagagaaagt     9600

gaccaactgg ttgcagagca acggatggga taggctcaaa cgaatggcag tcagtggaga     9660

tgattgcgtt gtgaagccaa ttgatgatag gtttgcacat gccctcaggt tcttgaatga     9720

tatgggaaaa gttagaaagg acacacaaga gtggaaaccc tcaactggat gggacaactg     9780

ggaagaagtt ccgttttgct cccaccactt caacaagctc catctcaagg acgggaggtc     9840

cattgtggtt ccctgccgcc accaagatga actgattggc cgggcccgcg tctctccagg     9900

ggcgggatgg agcatccggg agactgcttg cctagcaaaa tcatatgcgc agatgtggca     9960

gctcctttat ttccacagaa gggacctccg actgatggcc aatgccattt gttcatctgt    10020

gccagttgac tgggttccaa ctgggagaac tacctggtca atccatggaa agggagaatg    10080

gatgaccact gaagacatgc ttgtggtgtg gaacagagtg tggattgagg agaacgacca    10140

catggaagac aagaccccag ttacgaaatg gacagacatt ccctatttgg gaaaaaggga    10200

agacttgtgg tgtggatctc tcatagggca cagaccgcgc accacctggg ctgagaacat    10260

taaaaacaca gtcaacatgg tgcgcaggat cataggtgat gaagaaaagt acatggacta    10320

cctatccacc caagttcgct acttgggtga agaagggtct acacctggag tgctgtaagc    10380

accaatttta gtgttgtcag gcctgctagt cagccacagt ttggggaaag ctgtgcagcc    10440

tgtaaccccc ccaggagaag ctgggaaacc aagctcatag tcaggccgag aacgccatgg    10500

cacggaagaa gccatgctgc ctgtgagccc ctcagaggac actgagtcaa aaaaccccac    10560

gcgcttggaa gcgcaggatg ggaaaagaag gtggcgacct tccccaccct tcaatctggg    10620

gcctgaactg gagactagct gtgaatctcc agcagaggga ctagtggtta gaggagaccc    10680

cccggaaaac gcaaaacagc atattgacgc tgggaaagac cagagactcc atgagtttcc    10740

accacgctgg ccgccaggca cagatcgccg aacagcggcg gccggtgtgg ggaaatccat    10800

ggtttct                                                              10807


<210>  3
<211>  10807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Genomic sequence of chimeric ZIKVBR15-MC mutant miR4279 (10,807 
       nt)

<400>  3
agttgttgat ctgtgtgagt cagactgcga cagttcgagt ctgaagcgag agctaacaac       60

agtatcaaca ggtttaattt ggatttggaa acgagagttt ctggtcatga aaaacccaaa      120

aaagaaatcc ggaggattcc ggattgtcaa tatgctaaaa cgcggagtag cccgtgtgag      180

cccctttggg ggcttgaaga ggctgccagc cggacttctg ctgggtcatg ggcccatcag      240

gatggtcttg gcgattctag cctttttgag attcacggca atcaagccat cactgggtct      300

catcaataga tggggttcag ttgggaaaaa agaggctatg gaaataataa agaagttcaa      360

gaaagatctg gctgccatgc tgagaataat caatgctagg aaggagaaga agagacgagg      420

cgcagatact agtgtcggaa ttgttggcct cctgctgacc acagctatgg cagcggaggt      480

cactagacgt gggagtgcat actatatgta cttggacaga aacgatgctg gggaggccat      540

atcttttcca accacattgg ggatgaataa gtgttatata cagatcatgg atcttggaca      600

catgtgtgat gccaccatga gctatgaatg ccctatgctg gatgaggggg tggaaccaga      660

tgacgtcgat tgttggtgca acacgacgtc aacttgggtt gtgtacggaa cctgccatca      720

caaaaaaggt gaagcacgga gatctagaag agctgtgacg ctcccctccc attccactag      780

gaagctgcaa acgcggtcgc aaacctggtt ggaatcaaga gaatacacaa agcacttgat      840

tagagtcgaa aattggatat tcaggaaccc tggcttcgcg ttagcagcag ctgccatcgc      900

ttggcttttg ggaagctcaa cgagccaaaa agtcatatac ttggtcatga tactgctgat      960

tgccccggca tacagcatca ggtgcatagg agtcagcaat agggactttg tggaaggtat     1020

gtcaggtggg acttgggttg atgttgtctt ggaacatgga ggttgtgtca ccgtaatggc     1080

acaggacaaa ccgactgtcg acatagagct ggttacaaca acagtcagca acatggcgga     1140

ggtacgatcg tactgctatg aggcatcaat atcagacatg gcttcggaca gccgctgccc     1200

aacacaaggt gaagcctacc ttgacaagca atcagacact caatatgtct gcaaaagaac     1260

gttagtggac agaggctggg gaaatggatg tggacttttt ggcaaaggga gcctggtgac     1320

atgcgctaag tttgcatgct ccaagaaaat gaccgggaag agcatccagc cagagaatct     1380

ggagtaccgg ataatgctgt cagttcatgg ctcccagcac agtgggatga ctgtcaatga     1440

tataggatat gaaactgatg agaatagagc gaaagttgag ataacgccca attcaccaag     1500

agccgaagcc accctggggg gttttggaag cctaggactt gattgtgaac cgaggacagg     1560

ccttgacttt tcagatttgt attacttgac tatgaataac aagcactggt tggttcacaa     1620

ggagtggttc cacgacattc cattaccttg gcacgctggg gcagacaccg gaactccaca     1680

ctggaacaac aaagaagcac tggtagagtt caaggacgca catgccaaaa ggcaaactgt     1740

cgtggttcta gggagtcaag aaggagcagt tcacacggcc cttgctggag ctctggaggc     1800

tgagatggat ggtgcaaagg gaaggctgtc ctctggccac ttgaaatgtc gcctgaaaat     1860

ggataaactt agattgaagg gcgtgtcata ctccttgtgt actgcagcgt tcacattcac     1920

caagatcccg gctgaaacac tgcacgggac agtcacagtg gaggtacagt acgcagggac     1980

agatggacct tgcaaggttc cagctcagat ggcggtggac atgcaaactc tgaccccagt     2040

tgggaggttg ataaccgcta accccgtaat cactgaaagc actgagaact ctaagatgat     2100

gctggaactt gatccaccat ttggggactc ttacattgtc ataggagtcg gggagaagaa     2160

gatcacccac cactggcaca ggagtggcag caccattgga aaagcatttg aggccactgt     2220

gagaggcgcc aagagaatgg cagtcctggg ggacacagcc tgggactttg gatcagttgg     2280

aggcgctctc aactcattgg gcaagggcat ccatcaaatt tttggagcag ctttcaaatc     2340

attgtttgga ggaatgtcct ggttctcaca aattctcatt ggaacgttgc tgatgtggtt     2400

gggtctgaac acaaagaatg gatctatttc ccttatgtgc ttggccttag ggggggtgtt     2460

gatcttctta tccacagccg tctctgctga tgtggggtgc tcggtggact tctcaaagaa     2520

ggagacgaga tgcggtacag gggtgttcgt ctataacgac gttgaagcct ggagggacag     2580

gtacaagtac catcctgact ccccccgtag attggcagca gcagtcaagc aagcctggga     2640

agatggtatc tgcgggatct cctctgtttc aagaatggaa aacatcatgt ggagatcagt     2700

agaaggggag ctcaacgcta tcctagagga gaatggagtt caactgacgg tcgttgtggg     2760

atctgtaaaa aaccccatgt ggagaggtcc acagagattg cccgtgcctg tgaacgagct     2820

gccccacggc tggaaggctt gggggaaatc gtacttcgtc agagcagcaa agacaaataa     2880

cagctttgtc gtggatggtg acacactgaa ggaatgccca ctcaaacata gagcatggaa     2940

cagctttctt gtggaggatc atgggttcgg ggtatttcac actagtgtct ggctcaaggt     3000

tagagaagat tattcattag agtgtgatcc agccgttatt ggaacagctg ttaagggaaa     3060

ggaggctgta cacagtgatc taggctactg gattgagagt gagaagaatg acacatggag     3120

gctgaagagg gcccatctga tcgagatgaa aacatgtgaa tggccaaagt cccacacatt     3180

gtggacagat ggaatagaag agagtgatct gatcataccc aagtctttag ctgggccact     3240

cagccatcac aataccagag agggctacag gacccaaatg aaagggccat ggcacagtga     3300

agagcttgaa attcggtttg aggaatgccc aggcactaag gtttacgtgg aggagacatg     3360

tggaacaaga ggaccatctc tgagatcaac cactgcaagc ggaagggtga tcgaggaatg     3420

gtgctgcagg gagtgcacaa tgcccccact gtcgttccgg gctaaagatg gctgttggta     3480

tggaatggag ataaggccca ggaaagaacc agaaagcaac ttagtaaggt caatggtgac     3540

tgcaggatca actgatcaca tggaccactt ctcccttgga gtgcttgtga tcctgctcat     3600

ggtgcaggaa gggctgaaga agagaatgac cacaaagatc atcataagca catcaatggc     3660

agtgctggta gctatgatcc tgggaggatt ttcaatgagt gacctggcta agcttgcaat     3720

tttgatgggt gccaccttcg cggaaatgaa cactggagga gatgtagctc atctggcgct     3780

gatagcggca ttcaaagtca gaccagcgtt gctggtatct ttcatcttca gagctaattg     3840

gacaccccgt gaaagcatgc tgctggcctt ggcctcgtgt cttttgcaaa ctgcgatctc     3900

cgccttggaa ggcgacctga tggttctcat caatggtttt gctttggcct ggttggcaat     3960

acgagcgatg gttgttccac gcactgataa catcaccttg gcaatcctgg ctgctctgac     4020

accactggcc cggggcacac tgcttgtggc gtggagagca ggccttgcta cttgcggggg     4080

gtttatgctc ctctctctga agggaaaagg cagtgtgaag aagaacttac catttgtcat     4140

ggccctggga ctaaccgctg tgaggctggt cgaccccatc aacgtggtgg gactgctgtt     4200

actcacaagg agtgggaagc ggagctggcc ccctagcgaa gtactcacag ctgttggcct     4260

gatatgcgca ttggctggag ggttcgccaa ggcagatata gagatggctg ggcccatggc     4320

cgcggtcggt ctgctaattg tcagttacgt ggtctcagga aagagtgtgg acatgtacat     4380

tgaaagagca ggtgacatca catgggaaaa agatgcggaa gtcactggaa acagtccccg     4440

gctcgatgtg gcgctagatg agagtggtga tttctccctg gtggaggatg acggtccccc     4500

catgagagag atcatactca aggtggtcct gatgaccatc tgtggcatga atccaatagc     4560

catacccttt gcagctggag cgtggtacgt atacgtgaag actggaaaaa ggagtggtgc     4620

tctatgggat gtgcctgctc ccaaggaagt aaaaaagggg gagaccacag atggagtgta     4680

cagagtaatg actcgtagac tgctaggttc aacacaagtt ggagtgggag ttatgcaaga     4740

gggggtcttt cacactatgt ggcacgtcac aaaaggatcc gcgctgagaa gcggtgaagg     4800

gagacttgat ccatactggg gagatgtcaa gcaggatctg gtgtcatact gtggtccatg     4860

gaagctagat gccgcctggg acgggcacag cgaggtgcag ctcttggccg tgccccccgg     4920

agagagagcg aggaacatcc agactctgcc cggaatattt aagacaaagg atggggacat     4980

tggagcggtt gcgctggatt acccagcagg aacttcagga tctccaatcc tagacaagtg     5040

tgggagagtg ataggacttt atggcaatgg ggtcgtgatc aaaaatggga gttatgttag     5100

tgccatcacc caagggaaga gggaggagga gactcctgtt gagtgcttcg agccctcgat     5160

gctgaagaag aagcagctaa ctgtcttaga cttgcatcct ggagctggga aaaccaggag     5220

agttcttcct gaaatagtcc gtgaagccat aaaaacaaga ctccgtactg tgatcttagc     5280

tccaaccagg gttgtcgctg ctgaaatgga ggaggccctt agagggcttc cagtgcgtta     5340

tatgacaaca gcagtcaatg tcacccactc tggaacagaa atcgtcgact taatgtgcca     5400

tgccaccttc acttcacgtc tactacagcc aatcagagtc cccaactata atctgtatat     5460

tatggatgag gcccacttca cagatccctc aagtatagca gcaagaggat acatttcaac     5520

aagggttgag atgggcgagg cggctgccat cttcatgacc gccacgccac caggaacccg     5580

tgacgcattt ccggactcca actcaccaat tatggacacc gaagtggaag tcccagagag     5640

agcctggagc tcaggctttg attgggtgac ggatcattct ggaaaaacag tttggtttgt     5700

tccaagcgtg aggaacggca atgagatcgc agcttgtctg acaaaggctg gaaaacgggt     5760

catacagctc agcagaaaga cttttgagac agagttccag aaaacaaaac atcaagagtg     5820

ggactttgtc gtgacaactg acatttcaga gatgggcgcc aactttaaag ctgaccgtgt     5880

catagattcc aggagatgcc taaagccggt catacttgat ggcgagagag tcattctggc     5940

tggacccatg cctgtcacac atgccagcgc tgctcagagg agagggcgca taggcaggaa     6000

tcccaacaaa cctggagatg agtatctgta tggaggtggg tgcgcagaga ctgacgaaga     6060

ccatgcacac tggcttgaag caagaatgct ccttgacaat atttacctcc aagatggcct     6120

catagcctcg ctctatcgac ctgaggccga caaagtagca gccattgagg gagagttcaa     6180

gcttaggacg gagcaaagga agacctttgt ggaactcatg aagagaggag accttcctgt     6240

ttggctggcc tatcaggttg catctgccgg aataacctac acagatagaa gatggtgctt     6300

tgatggcacg accaacaaca ccataatgga agatagtgtg ccggcagagg tgtggaccag     6360

acacggagag aaaagagtgc tcaaaccgag gtggatggac gccagagttt gttcagatca     6420

tgcggccctg aagtcattca aggagtttgc cgctgggaaa agaggagcgg cttttggagt     6480

gatggaagcc ctgggaacac tgccaggaca catgacagag agattccagg aagccattga     6540

caacctcgct gtgctcatgc gggcagagac tggaagcagg ccttacaaag ccgcggcggc     6600

ccaattgccg gagaccctag agaccataat gcttttgggg ttgctgggaa cagtctcgct     6660

gggaatcttc ttcgtcttga tgaggaacaa gggcataggg aagatgggct ttggaatggt     6720

gactcttggg gccagcgcat ggctcatgtg gctctcggaa attgagccag ccagaattgc     6780

atgtgtcctc attgttgtgt tcctattgct ggtggtgctc atacctgagc cagaaaagca     6840

aagatctccc caggacaacc aaatggcaat catcatcatg gtagcagtag gtcttctggg     6900

cttgattacc gccaatgaac tcggatggtt ggagagaaca aagagtgacc taagccatct     6960

aatgggaagg agagaggagg gggcaaccat aggattctca atggacattg acctgcggcc     7020

agcctcagct tgggccatct atgctgcctt gacaactttc attaccccag ccgtccaaca     7080

tgcagtgacc acttcataca acaactactc cttaatggcg atggccacgc aagctggagt     7140

gttgtttggt atgggcaaag ggatgccatt ctacgcatgg gactttggag tcccgctgct     7200

aatgataggt tgctactcac aattaacacc cctgacccta atagtggcca tcattttgct     7260

cgtggcgcac tacatgtact tgatcccagg gctgcaggca gcagctgcgc gtgctgccca     7320

gaagagaacg gcagctggca tcatgaagaa ccctgttgtg gatggaatag tggtgactga     7380

cattgacaca atgacaattg acccccaagt ggagaaaaag atgggacagg tgctactcat     7440

agcagtagcc gtctccagcg ccatactgtc gcggaccgcc tgggggtggg gggaggctgg     7500

ggccctgatc acagccgcaa cttccacttt gtgggaaggc tctccgaaca agtactggaa     7560

ctcctctaca gccacttcac tgtgtaacat ttttagggga agttacttgg ctggagcttc     7620

tctaatctac acagtaacaa gaaacgctgg cttggtcaag agacgtgggg gtggaacagg     7680

agagaccctg ggagagaaat ggaaggcccg cttgaaccag atgtcggccc tggagttcta     7740

ctcctacaaa aagtcaggca tcaccgaggt gtgcagagaa gaggcccgcc gcgccctcaa     7800

ggacggtgtg gcaacgggag gccatgctgt gtcccgagga agtgcaaagc tgagatggtt     7860

ggtggagcgg ggatacctgc agccctatgg aaaggtcatt gatcttggat gtggcagagg     7920

gggctggagt tactacgccg ccaccatccg caaagttcaa gaagtgaaag gatacacaaa     7980

aggaggccct ggtcatgaag aacccgtgtt ggtgcaaagc tatgggtgga acatagtccg     8040

tcttaagagt ggggtggacg tctttcatat ggcggctgag ccgtgtgaca cgctgctgtg     8100

tgacataggt gagtcatcat ctagtcctga agtggaagaa gcacggacgc tcagagtcct     8160

ctccatggtg ggggattggc ttgaaaaaag accaggagcc ttttgtataa aagtgttgtg     8220

cccatacacc agcactatga tggaaaccct ggagcgactg cagcgtaggt atgggggagg     8280

actggtcaga gtgccactct cccgcaactc tacacatgag atgtactggg tctctggagc     8340

gaaaagcaac accataaaaa gtgtgtccac cacgagccag ctcctcttgg ggcgcatgga     8400

cgggcctagg aggccagtga aatatgagga ggatgtgaat ctcggctctg gcacgcgggc     8460

tgtggtaagc tgcgctgaag ctcccaacat gaagatcatt ggtaaccgca ttgaaaggat     8520

ccgcagtgag cacgcggaaa cgtggttctt tgacgagaac cacccatata ggacatgggc     8580

ttaccatgga agctatgagg cccccacaca agggtcagcg tcctctctaa taaacggggt     8640

tgtcaggctc ctgtcaaaac cctgggatgt ggtgactgga gtcacaggaa tagccatgac     8700

cgacaccaca ccgtatggtc agcaaagagt tttcaaggaa aaagtggaca ctagggtgcc     8760

agacccccaa gaaggcactc gtcaggttat gagcatggtc tcttcctggt tgtggaaaga     8820

gctaggcaaa cacaaacggc cacgagtctg taccaaagaa gagttcatca acaaggttcg     8880

tagcaatgca gcattagggg caatatttga agaggaaaaa gagtggaaga ctgcagtgga     8940

agctgtgaac gatccaaggt tctgggctct agtggacaag gaaagagagc accacctgag     9000

aggagagtgc cagagttgtg tgtataacat gatgggaaaa agagaaaaga aacaagggga     9060

atttggaaag gccaagggca gccgcgccat ctggtatatg tggctagggg ctagatttct     9120

agagttcgaa gcccttggat tcttgaacga ggatcactgg atggggagag agaactcagg     9180

aggtggtgtt gaagggctgg gattacaaag actcggatat gtcctagaag agatgagtcg     9240

tataccagga ggaaggatgt atgcagatga cactgctggc tgggacaccc gcattagcag     9300

gtttgatctg gagaatgaag ctctaatcac caaccaaatg gagaaagggc acagggcctt     9360

ggcattggcc ataatcaagt acacatacca aaacaaagtg gtaaaggtcc ttagaccagc     9420

tgaaaaaggg aaaacagtta tggacattat ttcgagacaa gaccaaaggg ggagcggaca     9480

agttgtcact tacgctctta acacatttac caacctagtg gtgcaactca ttcggaatat     9540

ggaggctgag gaagttctag agatgcaaga cttgtggctg ctgcggaggt cagagaaagt     9600

gaccaactgg ttgcagagca acggatggga taggctcaaa cgaatggcag tcagtggaga     9660

tgattgcgtt gtgaagccaa ttgatgatag gtttgcacat gccctcaggt tcttgaatga     9720

tatgggaaaa gttagaaagg acacacaaga gtggaaaccc tcaactggat gggacaactg     9780

ggaagaagtt ccgttttgct cccaccactt caacaagctc catctcaagg acgggaggtc     9840

cattgtggtt ccctgccgcc accaagatga actgattggc cgggcccgcg tctctccagg     9900

ggcgggatgg agcatccggg agactgcttg cctagcaaaa tcatatgcgc agatgtggca     9960

gctcctttat ttccacagaa gggacctccg actgatggcc aatgccattt gttcatctgt    10020

gccagttgac tgggttccaa ctgggagaac tacctggtca atccatggaa agggagaatg    10080

gatgaccact gaagacatgc ttgtggtgtg gaacagagtg tggattgagg agaacgacca    10140

catggaagac aagaccccag ttacgaaatg gacagacatt ccctatttgg gaaaaaggga    10200

agacttgtgg tgtggatctc tcatagggca cagaccgcgc accacctggg ctgagaacat    10260

taaaaacaca gtcaacatgg tgcgcaggat cataggtgat gaagaaaagt acatggacta    10320

cctatccacc caagttcgct acttgggtga agaagggtct acacctggag tgctgtaagc    10380

accaatttta gtgttgtcag gcctgctagt cagccacagt ttggggaaag ctgtgcagcc    10440

tgtaaccccc ccaggagaag ctgggaaacc aagctcatag tcaggccgag aacgccatgg    10500

cacggaagaa gccatgctgc ctgtgagccc ctcagaggac actgagtcaa aaaaccccac    10560

gcgcttggaa gcgcaggatg ggaaaagaag gtggcgacct tccccaccct tcaatctggg    10620

gcctgaactg gagactagct gtgaatctcc agcagaggga ctagtggtta gaggagaccc    10680

cccggaaaac gcaaaacagc atattgacgc tgggaaagac cagagactcc atgagtttcc    10740

accacgctgg ccgccaggca cagatcgccg aacagcggcg gccggtgtgg ggaaatccat    10800

ggtttct                                                              10807


<210>  4
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence figure 1

<400>  4
ctatcctaga ggagaa                                                       16


<210>  5
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence figure 1

<400>  5
tttacgtgga ggaga                                                        15


<210>  6
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence figure 1

<400>  6
agagggagga ggagac                                                       16


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence figure 1

<400>  7
gctgctcaga ggagag                                                       16


<210>  8
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence figure 1

<400>  8
catgaagaga ggagac                                                       16


<210>  9
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence figure 1

<400>  9
catgaagaga ggagac                                                       16


