                         SEQUENCE LISTING

<110>  LifeSeq Limited Corporation
 
<120>  ߼弰߼ƷӵĹＰӦ

<130>  PIDC3163330P

<160>  160   

<170>  PatentIn version 3.3

<210>  1
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  İ

<400>  1

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Ser 
            180                 185                 190         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        195                 200                 205             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    210                 215                 220                 


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
225                 230                 235                 240 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                245                 250                 255     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            260                 265                 270         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        275                 280                 285             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    290                 295                 300                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
305                 310                 315                 320 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                325                 330                 335     


Met Gln Ala Leu Pro Pro Arg 
            340             


<210>  2
<211>  346
<212>  PRT
<213>  Artificial

<220>
<223>  İ

<400>  2

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Leu Phe 
145                 150                 155                 160 


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
                165                 170                 175     


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            180                 185                 190         


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
        195                 200                 205             


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
    210                 215                 220                 


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
225                 230                 235                 240 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
                245                 250                 255     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            260                 265                 270         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        275                 280                 285             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    290                 295                 300                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
305                 310                 315                 320 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                325                 330                 335     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345     


<210>  3
<211>  1032
<212>  DNA
<213>  Artificial

<220>
<223>  ĺĺ

<400>  3
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc    480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc    540

ctggtgctgc tagtctgggt cctggccgtc atcagtaaga ggagcaggct cctgcacagt    600

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat    660

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac    720

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    780

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    840

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    900

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    960

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1020

ccccctcgct aa                                                       1032


<210>  4
<211>  1041
<212>  DNA
<213>  Artificial

<220>
<223>  ĺĺ

<400>  4
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacccaag tcccctattt    480

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat    540

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc    600

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac    660

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg    720

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta    780

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg    840

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag    900

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac    960

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg   1020

caggccctgc cccctcgcta a                                             1041


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  5
ggccaggatg gttcttagac t                                               21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  6
ggatttccag tggcgagaga a                                               21


<210>  7
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  7
gccuguguuc ucuguggacu aug                                             23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  8
ggugcugcua gucugggucc ugg                                             23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  9
gacagagaga agggcagaag ugc                                             23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  10
cagcuucucc aacacaucgg aga                                             23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  11
ccgugucaca caacugccca acg                                             23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  12
uaugccacca uugucuuucc uag                                             23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  13
ugcuaaacug guaccgcaug agc                                             23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  14
gugacagaga gaagggcaga agu                                             23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  15
cugaggaugg acacugcucu ugg                                             23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PD1siRNA

<400>  16
aucggagagc uucgugcuaa acu                                             23


<210>  17
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  17
ggcaacggaa cccagattta t                                               21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  18
ggaacccaaa ttacgtgtac t                                               21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  19
gaacccaaat tacgtgtact a                                               21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  20
gggagaagac tatattgtac a                                               21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  21
gacgtttata gccgaaatga t                                               21


<210>  22
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  22
gacactaata caccaggtag a                                               21


<210>  23
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  23
accucacuau ccaaggacug agg                                             23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  24
augaguugac cuuccuagau gau                                             23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  25
ggggaaugag uugaccuucc uag                                             23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  26
cucuggaucc uugcagcagu uag                                             23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  27
cuccucugga uccuugcagc agu                                             23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  28
uuugugugug aguaugcauc ucc                                             23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  29
caccuccagu ggaaaucaag uga                                             23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  30
cacgggacuc uacaucugca agg                                             23


<210>  31
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  31
uucugacuuc cuccucugga ucc                                             23


<210>  32
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CTLA4siRNA

<400>  32
aagucugugc ggcaaccuac aug                                             23


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  33
ggtcggtcag aatgcctatc t                                               21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  34
gccaatgact tacgggactc t                                               21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  35
gcagagggaa ttcgctcaga a                                               21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  36
ggaaattcgg gcacatcata t                                               21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  37
gattaagaga tgactggact a                                               21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  38
gagatgactg gactaggtct a                                               21


<210>  39
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  39
aggaaauucg ggcacaucau aug                                             23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  40
gacugaugaa agggauguga auu                                             23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  41
gccacugauu uucaaagaga ucu                                             23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  42
agcagaguuu ucccauuuuc aga                                             23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  43
aacuuaaaca ggcaugucau ugc                                             23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  44
uucagaagau aaugacucac aug                                             23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  45
gccucuguau uuaagccaac aga                                             23


<210>  46
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  46
ugcucaugug auuguggagu aga                                             23


<210>  47
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  47
auguuuucac aucuucccuu uga                                             23


<210>  48
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  TIM3siRNA

<400>  48
gagagacuuc acugcagccu uuc                                             23


<210>  49
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  49
gattgcctct actcatcact a                                               21


<210>  50
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  50
uccuaaugac aaugggucau acc                                             23


<210>  51
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  51
aagacauugc cugccaugcu ugg                                             23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  52
gucauaccgc uguucugcaa auu                                             23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  53
cuccuguaua guuuacuucc uuu                                             23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  54
uaccgcuguu cugcaaauuu uca                                             23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  55
aaaacaaacc aggcauuguu uau                                             23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  56
aacuagaaug cccugugaaa uac                                             23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  57
gugacuuggu gcaagcucaa ugg                                             23


<210>  58
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  58
auccauggga aagaaucaug uga                                             23


<210>  59
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  BTLAsiRNA

<400>  59
uggugcaagc ucaauggaac aac                                             23


<210>  60
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  60
gctgctcacc cttatgaacc t                                               21


<210>  61
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  61
aggacauggu gguggacgag ugc                                             23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  62
ugcucuuccu gcacgauauc agu                                             23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  63
accucuacug guuccuguac auc                                             23


<210>  64
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  64
cccuccaacu cugcuccucu agg                                             23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  65
cccugagugg acagucgucu ucg                                             23


<210>  66
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  66
cugcuccagg gaagcuucua ugg                                             23


<210>  67
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  67
cgcucaaggu ccuguaugcc acc                                             23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  68
gaguucacca agcucaacau uua                                             23


<210>  69
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  69
ugcugcugcu cacccuuaug aac                                             23


<210>  70
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  LAG1siRNA

<400>  70
cccaucuccg ugcucuucuu uga                                             23


<210>  71
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  71
gggacatcgt cgagctattc a                                               21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  72
ggacatcgtc gagctattca t                                               21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  73
gccaatgtca ccgtggataa t                                               21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  74
gtcatctgtg gcagtatatc a                                               21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  75
ggatgtagag tagtgttaga t                                               21


<210>  76
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  76
ggcaaagtta agaccatcaa t                                               21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  77
gaccaaatcc acgctcaatt a                                               21


<210>  78
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  78
uacugcuuaa aucuuccauc agc                                             23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  79
gacugagaag uucugucuga uuu                                             23


<210>  80
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  80
cuguuucauc acccaaacau acu                                             23


<210>  81
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  81
gaagauccuc ccacaucacu aaa                                             23


<210>  82
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  82
uagaccaagg uaaaagugga aca                                             23


<210>  83
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  83
aagagguuuu uaucugagcu uga                                             23


<210>  84
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  84
uaccugcaca acguucaacc aug                                             23


<210>  85
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  85
gccuggauuc augucucuca uuu                                             23


<210>  86
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  86
cccucggaau uucucugcca agc                                             23


<210>  87
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  IRAK-M (ϸ-1ؼø3) siRNA

<400>  87
ugcugaagau ccucccacau cac                                             23


<210>  88
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  88
gcacctccta cctcttcatg t                                               21


<210>  89
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  89
cgcacuuccg cacauuccgu ucg                                             23


<210>  90
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  90
ggggaggguc ucuggcuuua uuu                                             23


<210>  91
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  91
cagcauuaac ugggaugccg ugu                                             23


<210>  92
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  92
ccaggaccug aacucgcacc ucc                                             23


<210>  93
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  93
uacauauacc caguaucuuu gca                                             23


<210>  94
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  94
gccgacaaug cagucuccac agc                                             23


<210>  95
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  95
ccccugguug uuguagcagc uua                                             23


<210>  96
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  96
cugcugugca gaauccuauu uua                                             23


<210>  97
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  97
ugggaugccg uguuauuuug uua                                             23


<210>  98
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  SOCS1ϸźת1siRNA

<400>  98
ucgcaccucc uaccucuuca ugu                                             23


<210>  99
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  99
gcggaaagct gtgaagatac g                                               21


<210>  100
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  100
acaaagccct catcgacaga a                                               21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  101
atgccacttc tcagtacatg t                                               21


<210>  102
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  102
gtggacttca gtacaactca c                                               21


<210>  103
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  103
gtggaattta cttgcctctc c                                               21


<210>  104
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  104
gttggatgaa gctaacttac c                                               21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  105
actgggaaga cgtgtaactc t                                               21


<210>  106
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  106
aaggaattgc atccaaggta t                                               21


<210>  107
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  107
ggaattgcat ccaaggtata c                                               21


<210>  108
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  108
ggatgagact ggcaatggtc a                                               21


<210>  109
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  109
uccucaguuu cgggagauca ucc                                             23


<210>  110
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  110
gagucucuca aaucucagga auu                                             23


<210>  111
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  111
agcucuaguc cuuuuugugu aau                                             23


<210>  112
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  112
cacuggaaau guucagaacu ugc                                             23


<210>  113
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  113
augaugaaug ggacaaucuu auc                                             23


<210>  114
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  114
cacacugugu uucaucgagu aca                                             23


<210>  115
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  115
gcagaaccau ccauggacug uga                                             23


<210>  116
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  116
aaagaugugg ccuuuuguga ugg                                             23


<210>  117
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  117
uucagaacuu gccaguuuug ucc                                             23


<210>  118
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  A20 (-յA20) siRNA

<400>  118
augagacugg caauggucac agg                                             23


<210>  119
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CBL-BsiRNA

<400>  119
gtcaattcca gggagataac t                                               21


<210>  120
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CBL-BsiRNA

<400>  120
gcctggaagc aatggctcta a                                               21


<210>  121
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CBL-BsiRNA

<400>  121
gcaccaaacc cggaagctat a                                               21


<210>  122
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CBL-BsiRNA

<400>  122
gttgcactcg attgggacag t                                               21


<210>  123
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CBL-BsiRNA

<400>  123
ggattatgtg aacctacacc t                                               21


<210>  124
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CBL-BsiRNA

<400>  124
ggaatcacag cgagttcaaa t                                               21


<210>  125
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  125
gcaaggcata gtctcattga a                                               21


<210>  126
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  126
ggtgaagaga gccttagaga t                                               21


<210>  127
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  127
gtgaagagag ccttagagat a                                               21


<210>  128
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  128
aggagcuaag gucuuuucca aug                                             23


<210>  129
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  129
augucgaugc aaaaauugca aaa                                             23


<210>  130
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  130
gucacaugcu ggcagaaauc aaa                                             23


<210>  131
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  131
uccagguuac auggcauuuc uca                                             23


<210>  132
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  132
uugaacuuug aaccugugaa aug                                             23


<210>  133
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  133
uccacaucaa cagcuaaauc auu                                             23


<210>  134
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  134
augcuggcag aaaucaaagc aau                                             23


<210>  135
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  135
ugcagagaau gacaaagaug uca                                             23


<210>  136
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  (CBL-BsiRNA

<400>  136
ggcagaacuc accagucaca uca                                             23


<210>  137
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CBL-BsiRNA

<400>  137
ucgguccugu gauaaugguc acu                                             23


<210>  138
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  ޹EGFRİ

<400>  138

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Arg Lys Val Cys Asn Gly Ile Gly Ile 
            20                  25                  30          


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
        35                  40                  45              


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
    50                  55                  60                  


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
65                  70                  75                  80  


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
                85                  90                  95      


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
            100                 105                 110         


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
        115                 120                 125             


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
    130                 135                 140                 


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
145                 150                 155                 160 


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
                165                 170                 175     


Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr 
            180                 185                 190         


Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro 
        195                 200                 205             


Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu 
    210                 215                 220                 


Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val 
225                 230                 235                 240 


Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala 
                245                 250                 255     


Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys 
            260                 265                 270         


Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly 
        275                 280                 285             


Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly 
    290                 295                 300                 


His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly 
305                 310                 315                 320 


Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile 
                325                 330                 335     


Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu 
            340                 345                 350         


Gly Ile Gly Leu Phe Met Arg Arg 
        355                 360 


<210>  139
<211>  1083
<212>  DNA
<213>  Artificial

<220>
<223>  ޹EGFRĺӵĺ

<400>  139
atggctctgc ccgtcaccgc tctgctgctg cctctggctc tgctgctgca cgccgcacgc     60

cctgggagtc gcaaagtctg taatgggatc ggcatcggcg agttcaagga cagcctgtcc    120

atcaacgcca ccaatatcaa gcactttaag aattgcacat ctatcagcgg cgacctgcac    180

atcctgccag tggccttccg gggcgattct tttacccaca caccccctct ggaccctcag    240

gagctggata tcctgaagac cgtgaaggag atcacaggct tcctgctgat ccaggcctgg    300

cctgagaaca gaaccgatct gcacgccttt gagaatctgg agatcatccg gggcagaaca    360

aagcagcacg gccagttctc cctggccgtg gtgtctctga acatcaccag cctgggcctg    420

aggtccctga aggagatctc tgacggcgat gtgatcatct ccggcaacaa gaacctgtgc    480

tacgccaaca caatcaattg gaagaagctg tttggcacct ctggccagaa gacaaagatc    540

atctctaacc ggggcgagaa tagctgcaag gcaaccggac aggtgtgcca cgcactgtgc    600

agcccagagg gatgttgggg cccagagcca cgggactgcg tgagctgtag aaacgtgtcc    660

aggggccgcg agtgcgtgga taagtgtaat ctgctggagg gcgagccaag ggagttcgtg    720

gagaactccg agtgcatcca gtgtcacccc gagtgcctgc ctcaggccat gaacatcacc    780

tgtacaggcc gcggccccga caattgcatc cagtgtgccc actatatcga tggccctcac    840

tgcgtgaaga cctgtccagc cggcgtgatg ggcgagaaca atacactggt gtggaagtac    900

gcagacgcag gacacgtgtg ccacctgtgc caccccaatt gcacctatgg ctgtacagga    960

ccaggcctgg agggatgccc aaccaacggc cctaagatcc caagcatcgc cacaggcatg   1020

gtgggggcac tgctgctgct gctggtggtg gctctgggga ttgggctgtt tatgagaagg   1080

taa                                                                 1083


<210>  140
<211>  3346
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD-TM)-CD28 (IC)-CD3zeta-IRES- tEGFR-pA-U6-shPD1

<400>  140
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc    480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc    540

ctggtgctgc tagtctgggt cctggccgtc atcagtaaga ggagcaggct cctgcacagt    600

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat    660

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac    720

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    780

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    840

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    900

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    960

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1020

ccccctcgct aaaagcttgg taccctcgag gttaacgaat tcgaatttaa atcggatccg   1080

cggccgcgcc cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa   1140

ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg   1200

agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc   1260

gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct   1320

tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac   1380

aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc   1440

cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta   1500

ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg   1560

cctcggtgca catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg   1620

aaccacgggg acgtggtttt cctttgaaaa acacgatgat aatatggcca caaccatggc   1680

gtccggaatg gctctgcccg tcaccgctct gctgctgcct ctggctctgc tgctgcacgc   1740

cgcacgccct gggagtcgca aagtctgtaa tgggatcggc atcggcgagt tcaaggacag   1800

cctgtccatc aacgccacca atatcaagca ctttaagaat tgcacatcta tcagcggcga   1860

cctgcacatc ctgccagtgg ccttccgggg cgattctttt acccacacac cccctctgga   1920

ccctcaggag ctggatatcc tgaagaccgt gaaggagatc acaggcttcc tgctgatcca   1980

ggcctggcct gagaacagaa ccgatctgca cgcctttgag aatctggaga tcatccgggg   2040

cagaacaaag cagcacggcc agttctccct ggccgtggtg tctctgaaca tcaccagcct   2100

gggcctgagg tccctgaagg agatctctga cggcgatgtg atcatctccg gcaacaagaa   2160

cctgtgctac gccaacacaa tcaattggaa gaagctgttt ggcacctctg gccagaagac   2220

aaagatcatc tctaaccggg gcgagaatag ctgcaaggca accggacagg tgtgccacgc   2280

actgtgcagc ccagagggat gttggggccc agagccacgg gactgcgtga gctgtagaaa   2340

cgtgtccagg ggccgcgagt gcgtggataa gtgtaatctg ctggagggcg agccaaggga   2400

gttcgtggag aactccgagt gcatccagtg tcaccccgag tgcctgcctc aggccatgaa   2460

catcacctgt acaggccgcg gccccgacaa ttgcatccag tgtgcccact atatcgatgg   2520

ccctcactgc gtgaagacct gtccagccgg cgtgatgggc gagaacaata cactggtgtg   2580

gaagtacgca gacgcaggac acgtgtgcca cctgtgccac cccaattgca cctatggctg   2640

tacaggacca ggcctggagg gatgcccaac caacggccct aagatcccaa gcatcgccac   2700

aggcatggtg ggggcactgc tgctgctgct ggtggtggct ctggggattg ggctgtttat   2760

gagaaggtaa tcctactgcg aattctcgag cgactgtgcc ttctagttgc cagccatctg   2820

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt   2880

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg   2940

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg   3000

atgcggtggg ctctatgggt cgaccaaggt cgggcaggaa gagggcctat ttcccatgat   3060

tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac   3120

tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta   3180

gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa   3240

gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacacct ccccaggcgc   3300

agatcaaaga gagttcaaga gactctcttt gatctgcgcc tttttt                  3346


<210>  141
<211>  3338
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD-TM)-CD28 (IC)-CD3zeta-IRES- tEGFR-pA-U6-sh 
       CTLA4ĺӵ

<400>  141
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc    480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc    540

ctggtgctgc tagtctgggt cctggccgtc atcagtaaga ggagcaggct cctgcacagt    600

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat    660

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac    720

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    780

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    840

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    900

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    960

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1020

ccccctcgct aaaagcttgg taccctcgag gttaacgaat tcgaatttaa atcggatccg   1080

cggccgcgcc cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa   1140

ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg   1200

agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc   1260

gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct   1320

tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac   1380

aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc   1440

cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta   1500

ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg   1560

cctcggtgca catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg   1620

aaccacgggg acgtggtttt cctttgaaaa acacgatgat aatatggcca caaccatggc   1680

gtccggaatg gctctgcccg tcaccgctct gctgctgcct ctggctctgc tgctgcacgc   1740

cgcacgccct gggagtcgca aagtctgtaa tgggatcggc atcggcgagt tcaaggacag   1800

cctgtccatc aacgccacca atatcaagca ctttaagaat tgcacatcta tcagcggcga   1860

cctgcacatc ctgccagtgg ccttccgggg cgattctttt acccacacac cccctctgga   1920

ccctcaggag ctggatatcc tgaagaccgt gaaggagatc acaggcttcc tgctgatcca   1980

ggcctggcct gagaacagaa ccgatctgca cgcctttgag aatctggaga tcatccgggg   2040

cagaacaaag cagcacggcc agttctccct ggccgtggtg tctctgaaca tcaccagcct   2100

gggcctgagg tccctgaagg agatctctga cggcgatgtg atcatctccg gcaacaagaa   2160

cctgtgctac gccaacacaa tcaattggaa gaagctgttt ggcacctctg gccagaagac   2220

aaagatcatc tctaaccggg gcgagaatag ctgcaaggca accggacagg tgtgccacgc   2280

actgtgcagc ccagagggat gttggggccc agagccacgg gactgcgtga gctgtagaaa   2340

cgtgtccagg ggccgcgagt gcgtggataa gtgtaatctg ctggagggcg agccaaggga   2400

gttcgtggag aactccgagt gcatccagtg tcaccccgag tgcctgcctc aggccatgaa   2460

catcacctgt acaggccgcg gccccgacaa ttgcatccag tgtgcccact atatcgatgg   2520

ccctcactgc gtgaagacct gtccagccgg cgtgatgggc gagaacaata cactggtgtg   2580

gaagtacgca gacgcaggac acgtgtgcca cctgtgccac cccaattgca cctatggctg   2640

tacaggacca ggcctggagg gatgcccaac caacggccct aagatcccaa gcatcgccac   2700

aggcatggtg ggggcactgc tgctgctgct ggtggtggct ctggggattg ggctgtttat   2760

gagaaggtaa tcctactgcg aattctcgag cgactgtgcc ttctagttgc cagccatctg   2820

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt   2880

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg   2940

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg   3000

atgcggtggg ctctatgggt cgaccaaggt cgggcaggaa gagggcctat ttcccatgat   3060

tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac   3120

tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta   3180

gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa   3240

gtatttcgat ttcttggctt tatatatctt gtggaaagga ctccccgcat cacttgggat   3300

taatattcaa gagatattaa tcccaagtga tgcttttt                           3338


<210>  142
<211>  3342
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD-TM)-CD28 (IC)-CD3zeta-IRES- tEGFR-pA-U6-sh 
       CBL-Bĺӵ

<400>  142
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc    480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc    540

ctggtgctgc tagtctgggt cctggccgtc atcagtaaga ggagcaggct cctgcacagt    600

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat    660

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac    720

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    780

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    840

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    900

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    960

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1020

ccccctcgct aaaagcttgg taccctcgag gttaacgaat tcgaatttaa atcggatccg   1080

cggccgcgcc cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa   1140

ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg   1200

agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc   1260

gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct   1320

tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac   1380

aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc   1440

cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta   1500

ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg   1560

cctcggtgca catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg   1620

aaccacgggg acgtggtttt cctttgaaaa acacgatgat aatatggcca caaccatggc   1680

gtccggaatg gctctgcccg tcaccgctct gctgctgcct ctggctctgc tgctgcacgc   1740

cgcacgccct gggagtcgca aagtctgtaa tgggatcggc atcggcgagt tcaaggacag   1800

cctgtccatc aacgccacca atatcaagca ctttaagaat tgcacatcta tcagcggcga   1860

cctgcacatc ctgccagtgg ccttccgggg cgattctttt acccacacac cccctctgga   1920

ccctcaggag ctggatatcc tgaagaccgt gaaggagatc acaggcttcc tgctgatcca   1980

ggcctggcct gagaacagaa ccgatctgca cgcctttgag aatctggaga tcatccgggg   2040

cagaacaaag cagcacggcc agttctccct ggccgtggtg tctctgaaca tcaccagcct   2100

gggcctgagg tccctgaagg agatctctga cggcgatgtg atcatctccg gcaacaagaa   2160

cctgtgctac gccaacacaa tcaattggaa gaagctgttt ggcacctctg gccagaagac   2220

aaagatcatc tctaaccggg gcgagaatag ctgcaaggca accggacagg tgtgccacgc   2280

actgtgcagc ccagagggat gttggggccc agagccacgg gactgcgtga gctgtagaaa   2340

cgtgtccagg ggccgcgagt gcgtggataa gtgtaatctg ctggagggcg agccaaggga   2400

gttcgtggag aactccgagt gcatccagtg tcaccccgag tgcctgcctc aggccatgaa   2460

catcacctgt acaggccgcg gccccgacaa ttgcatccag tgtgcccact atatcgatgg   2520

ccctcactgc gtgaagacct gtccagccgg cgtgatgggc gagaacaata cactggtgtg   2580

gaagtacgca gacgcaggac acgtgtgcca cctgtgccac cccaattgca cctatggctg   2640

tacaggacca ggcctggagg gatgcccaac caacggccct aagatcccaa gcatcgccac   2700

aggcatggtg ggggcactgc tgctgctgct ggtggtggct ctggggattg ggctgtttat   2760

gagaaggtaa tcctactgcg aattctcgag cgactgtgcc ttctagttgc cagccatctg   2820

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt   2880

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg   2940

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg   3000

atgcggtggg ctctatgggt cgaccaaggt cgggcaggaa gagggcctat ttcccatgat   3060

tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac   3120

tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta   3180

gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa   3240

gtatttcgat ttcttggctt tatatatctt gtggaaagga ctccccaaca cagacgccat   3300

gatttgcttc aagagagcaa atcatggcgt ctgtgttttt tt                      3342


<210>  143
<211>  3342
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD-TM)-CD28 (IC)-CD3zeta-IRES- tEGFR-pA-U6-sh SOCS1

<400>  143
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc    480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc    540

ctggtgctgc tagtctgggt cctggccgtc atcagtaaga ggagcaggct cctgcacagt    600

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat    660

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac    720

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    780

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    840

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    900

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    960

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1020

ccccctcgct aaaagcttgg taccctcgag gttaacgaat tcgaatttaa atcggatccg   1080

cggccgcgcc cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa   1140

ggccggtgtg cgtttgtcta tatgttattt tccaccatat tgccgtcttt tggcaatgtg   1200

agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc   1260

gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct   1320

tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac   1380

aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc   1440

cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta   1500

ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg   1560

cctcggtgca catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg   1620

aaccacgggg acgtggtttt cctttgaaaa acacgatgat aatatggcca caaccatggc   1680

gtccggaatg gctctgcccg tcaccgctct gctgctgcct ctggctctgc tgctgcacgc   1740

cgcacgccct gggagtcgca aagtctgtaa tgggatcggc atcggcgagt tcaaggacag   1800

cctgtccatc aacgccacca atatcaagca ctttaagaat tgcacatcta tcagcggcga   1860

cctgcacatc ctgccagtgg ccttccgggg cgattctttt acccacacac cccctctgga   1920

ccctcaggag ctggatatcc tgaagaccgt gaaggagatc acaggcttcc tgctgatcca   1980

ggcctggcct gagaacagaa ccgatctgca cgcctttgag aatctggaga tcatccgggg   2040

cagaacaaag cagcacggcc agttctccct ggccgtggtg tctctgaaca tcaccagcct   2100

gggcctgagg tccctgaagg agatctctga cggcgatgtg atcatctccg gcaacaagaa   2160

cctgtgctac gccaacacaa tcaattggaa gaagctgttt ggcacctctg gccagaagac   2220

aaagatcatc tctaaccggg gcgagaatag ctgcaaggca accggacagg tgtgccacgc   2280

actgtgcagc ccagagggat gttggggccc agagccacgg gactgcgtga gctgtagaaa   2340

cgtgtccagg ggccgcgagt gcgtggataa gtgtaatctg ctggagggcg agccaaggga   2400

gttcgtggag aactccgagt gcatccagtg tcaccccgag tgcctgcctc aggccatgaa   2460

catcacctgt acaggccgcg gccccgacaa ttgcatccag tgtgcccact atatcgatgg   2520

ccctcactgc gtgaagacct gtccagccgg cgtgatgggc gagaacaata cactggtgtg   2580

gaagtacgca gacgcaggac acgtgtgcca cctgtgccac cccaattgca cctatggctg   2640

tacaggacca ggcctggagg gatgcccaac caacggccct aagatcccaa gcatcgccac   2700

aggcatggtg ggggcactgc tgctgctgct ggtggtggct ctggggattg ggctgtttat   2760

gagaaggtaa tcctactgcg aattctcgag cgactgtgcc ttctagttgc cagccatctg   2820

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt   2880

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg   2940

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg   3000

atgcggtggg ctctatgggt cgaccaaggt cgggcaggaa gagggcctat ttcccatgat   3060

tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa ttaatttgac   3120

tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta   3180

gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa   3240

gtatttcgat ttcttggctt tatatatctt gtggaaagga ctccccaaca cgcacttccg   3300

cacattcttc aagagagaat gtgcggaagt gcgtgttttt tt                      3342


<210>  144
<211>  3361
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD)-CD28 (TM-IC)-CD3zeta-IRES- tEGFR-pA-U6-sh PD1

<400>  144
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacccaag tcccctattt    480

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat    540

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc    600

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac    660

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg    720

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta    780

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg    840

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag    900

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac    960

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg   1020

caggccctgc cccctcgcta aaagcttggt accctcgagg ttaacgaatt cgaatttaaa   1080

tcggatccgc ggccgcgccc ctctccctcc ccccccccta acgttactgg ccgaagccgc   1140

ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt gccgtctttt   1200

ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc taggggtctt   1260

tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg   1320

gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg gaacccccca   1380

cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg   1440

gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa atggctctcc   1500

tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct   1560

gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta   1620

ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata atatggccac   1680

aaccatggcg tccggatcta gaatggctct gcccgtcacc gctctgctgc tgcctctggc   1740

tctgctgctg cacgccgcac gccctgggag tcgcaaagtc tgtaatggga tcggcatcgg   1800

cgagttcaag gacagcctgt ccatcaacgc caccaatatc aagcacttta agaattgcac   1860

atctatcagc ggcgacctgc acatcctgcc agtggccttc cggggcgatt cttttaccca   1920

cacaccccct ctggaccctc aggagctgga tatcctgaag accgtgaagg agatcacagg   1980

cttcctgctg atccaggcct ggcctgagaa cagaaccgat ctgcacgcct ttgagaatct   2040

ggagatcatc cggggcagaa caaagcagca cggccagttc tccctggccg tggtgtctct   2100

gaacatcacc agcctgggcc tgaggtccct gaaggagatc tctgacggcg atgtgatcat   2160

ctccggcaac aagaacctgt gctacgccaa cacaatcaat tggaagaagc tgtttggcac   2220

ctctggccag aagacaaaga tcatctctaa ccggggcgag aatagctgca aggcaaccgg   2280

acaggtgtgc cacgcactgt gcagcccaga gggatgttgg ggcccagagc cacgggactg   2340

cgtgagctgt agaaacgtgt ccaggggccg cgagtgcgtg gataagtgta atctgctgga   2400

gggcgagcca agggagttcg tggagaactc cgagtgcatc cagtgtcacc ccgagtgcct   2460

gcctcaggcc atgaacatca cctgtacagg ccgcggcccc gacaattgca tccagtgtgc   2520

ccactatatc gatggccctc actgcgtgaa gacctgtcca gccggcgtga tgggcgagaa   2580

caatacactg gtgtggaagt acgcagacgc aggacacgtg tgccacctgt gccaccccaa   2640

ttgcacctat ggctgtacag gaccaggcct ggagggatgc ccaaccaacg gccctaagat   2700

cccaagcatc gccacaggca tggtgggggc actgctgctg ctgctggtgg tggctctggg   2760

gattgggctg tttatgagaa ggtaatccta ctgcgaattc tcgagcgact gtgccttcta   2820

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca   2880

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc   2940

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata   3000

gcaggcatgc tggggatgcg gtgggctcta tgggtcgacc aaggtcgggc aggaagaggg   3060

cctatttccc atgattcctt catatttgca tatacgatac aaggctgtta gagagataat   3120

tagaattaat ttgactgtaa acacaaagat attagtacaa aatacgtgac gtagaaagta   3180

ataatttctt gggtagtttg cagttttaaa attatgtttt aaaatggact atcatatgct   3240

taccgtaact tgaaagtatt tcgatttctt ggctttatat atcttgtgga aaggacgaaa   3300

cacctcccca ggcgcagatc aaagagagtt caagagactc tctttgatct gcgccttttt   3360

t                                                                   3361


<210>  145
<211>  3353
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD)-CD28 (TM-IC)-CD3zeta-IRES- tEGFR-pA-U6-sh CTLA4

<400>  145
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacccaag tcccctattt    480

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat    540

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc    600

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac    660

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg    720

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta    780

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg    840

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag    900

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac    960

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg   1020

caggccctgc cccctcgcta aaagcttggt accctcgagg ttaacgaatt cgaatttaaa   1080

tcggatccgc ggccgcgccc ctctccctcc ccccccccta acgttactgg ccgaagccgc   1140

ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt gccgtctttt   1200

ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc taggggtctt   1260

tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg   1320

gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg gaacccccca   1380

cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg   1440

gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa atggctctcc   1500

tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct   1560

gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta   1620

ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata atatggccac   1680

aaccatggcg tccggatcta gaatggctct gcccgtcacc gctctgctgc tgcctctggc   1740

tctgctgctg cacgccgcac gccctgggag tcgcaaagtc tgtaatggga tcggcatcgg   1800

cgagttcaag gacagcctgt ccatcaacgc caccaatatc aagcacttta agaattgcac   1860

atctatcagc ggcgacctgc acatcctgcc agtggccttc cggggcgatt cttttaccca   1920

cacaccccct ctggaccctc aggagctgga tatcctgaag accgtgaagg agatcacagg   1980

cttcctgctg atccaggcct ggcctgagaa cagaaccgat ctgcacgcct ttgagaatct   2040

ggagatcatc cggggcagaa caaagcagca cggccagttc tccctggccg tggtgtctct   2100

gaacatcacc agcctgggcc tgaggtccct gaaggagatc tctgacggcg atgtgatcat   2160

ctccggcaac aagaacctgt gctacgccaa cacaatcaat tggaagaagc tgtttggcac   2220

ctctggccag aagacaaaga tcatctctaa ccggggcgag aatagctgca aggcaaccgg   2280

acaggtgtgc cacgcactgt gcagcccaga gggatgttgg ggcccagagc cacgggactg   2340

cgtgagctgt agaaacgtgt ccaggggccg cgagtgcgtg gataagtgta atctgctgga   2400

gggcgagcca agggagttcg tggagaactc cgagtgcatc cagtgtcacc ccgagtgcct   2460

gcctcaggcc atgaacatca cctgtacagg ccgcggcccc gacaattgca tccagtgtgc   2520

ccactatatc gatggccctc actgcgtgaa gacctgtcca gccggcgtga tgggcgagaa   2580

caatacactg gtgtggaagt acgcagacgc aggacacgtg tgccacctgt gccaccccaa   2640

ttgcacctat ggctgtacag gaccaggcct ggagggatgc ccaaccaacg gccctaagat   2700

cccaagcatc gccacaggca tggtgggggc actgctgctg ctgctggtgg tggctctggg   2760

gattgggctg tttatgagaa ggtaatccta ctgcgaattc tcgagcgact gtgccttcta   2820

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca   2880

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc   2940

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata   3000

gcaggcatgc tggggatgcg gtgggctcta tgggtcgacc aaggtcgggc aggaagaggg   3060

cctatttccc atgattcctt catatttgca tatacgatac aaggctgtta gagagataat   3120

tagaattaat ttgactgtaa acacaaagat attagtacaa aatacgtgac gtagaaagta   3180

ataatttctt gggtagtttg cagttttaaa attatgtttt aaaatggact atcatatgct   3240

taccgtaact tgaaagtatt tcgatttctt ggctttatat atcttgtgga aaggactccc   3300

cgcatcactt gggattaata ttcaagagat attaatccca agtgatgctt ttt          3353


<210>  146
<211>  3357
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD)-CD28 (TM-IC)-CD3zeta-IRES- tEGFR-pA-U6-sh CBL-B

<400>  146
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacccaag tcccctattt    480

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat    540

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc    600

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac    660

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg    720

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta    780

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg    840

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag    900

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac    960

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg   1020

caggccctgc cccctcgcta aaagcttggt accctcgagg ttaacgaatt cgaatttaaa   1080

tcggatccgc ggccgcgccc ctctccctcc ccccccccta acgttactgg ccgaagccgc   1140

ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt gccgtctttt   1200

ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc taggggtctt   1260

tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg   1320

gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg gaacccccca   1380

cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg   1440

gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa atggctctcc   1500

tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct   1560

gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta   1620

ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata atatggccac   1680

aaccatggcg tccggatcta gaatggctct gcccgtcacc gctctgctgc tgcctctggc   1740

tctgctgctg cacgccgcac gccctgggag tcgcaaagtc tgtaatggga tcggcatcgg   1800

cgagttcaag gacagcctgt ccatcaacgc caccaatatc aagcacttta agaattgcac   1860

atctatcagc ggcgacctgc acatcctgcc agtggccttc cggggcgatt cttttaccca   1920

cacaccccct ctggaccctc aggagctgga tatcctgaag accgtgaagg agatcacagg   1980

cttcctgctg atccaggcct ggcctgagaa cagaaccgat ctgcacgcct ttgagaatct   2040

ggagatcatc cggggcagaa caaagcagca cggccagttc tccctggccg tggtgtctct   2100

gaacatcacc agcctgggcc tgaggtccct gaaggagatc tctgacggcg atgtgatcat   2160

ctccggcaac aagaacctgt gctacgccaa cacaatcaat tggaagaagc tgtttggcac   2220

ctctggccag aagacaaaga tcatctctaa ccggggcgag aatagctgca aggcaaccgg   2280

acaggtgtgc cacgcactgt gcagcccaga gggatgttgg ggcccagagc cacgggactg   2340

cgtgagctgt agaaacgtgt ccaggggccg cgagtgcgtg gataagtgta atctgctgga   2400

gggcgagcca agggagttcg tggagaactc cgagtgcatc cagtgtcacc ccgagtgcct   2460

gcctcaggcc atgaacatca cctgtacagg ccgcggcccc gacaattgca tccagtgtgc   2520

ccactatatc gatggccctc actgcgtgaa gacctgtcca gccggcgtga tgggcgagaa   2580

caatacactg gtgtggaagt acgcagacgc aggacacgtg tgccacctgt gccaccccaa   2640

ttgcacctat ggctgtacag gaccaggcct ggagggatgc ccaaccaacg gccctaagat   2700

cccaagcatc gccacaggca tggtgggggc actgctgctg ctgctggtgg tggctctggg   2760

gattgggctg tttatgagaa ggtaatccta ctgcgaattc tcgagcgact gtgccttcta   2820

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca   2880

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc   2940

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata   3000

gcaggcatgc tggggatgcg gtgggctcta tgggtcgacc aaggtcgggc aggaagaggg   3060

cctatttccc atgattcctt catatttgca tatacgatac aaggctgtta gagagataat   3120

tagaattaat ttgactgtaa acacaaagat attagtacaa aatacgtgac gtagaaagta   3180

ataatttctt gggtagtttg cagttttaaa attatgtttt aaaatggact atcatatgct   3240

taccgtaact tgaaagtatt tcgatttctt ggctttatat atcttgtgga aaggactccc   3300

caacacagac gccatgattt gcttcaagag agcaaatcat ggcgtctgtg ttttttt      3357


<210>  147
<211>  3357
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD)-CD28(TM-IC)-CD3zeta-IRES- tEGFR-pA-U6-shSOCS1

<400>  147
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacccaag tcccctattt    480

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat    540

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc    600

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac    660

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg    720

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta    780

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg    840

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag    900

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac    960

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg   1020

caggccctgc cccctcgcta aaagcttggt accctcgagg ttaacgaatt cgaatttaaa   1080

tcggatccgc ggccgcgccc ctctccctcc ccccccccta acgttactgg ccgaagccgc   1140

ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt gccgtctttt   1200

ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc taggggtctt   1260

tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg   1320

gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg gaacccccca   1380

cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg   1440

gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa atggctctcc   1500

tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct   1560

gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta   1620

ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata atatggccac   1680

aaccatggcg tccggatcta gaatggctct gcccgtcacc gctctgctgc tgcctctggc   1740

tctgctgctg cacgccgcac gccctgggag tcgcaaagtc tgtaatggga tcggcatcgg   1800

cgagttcaag gacagcctgt ccatcaacgc caccaatatc aagcacttta agaattgcac   1860

atctatcagc ggcgacctgc acatcctgcc agtggccttc cggggcgatt cttttaccca   1920

cacaccccct ctggaccctc aggagctgga tatcctgaag accgtgaagg agatcacagg   1980

cttcctgctg atccaggcct ggcctgagaa cagaaccgat ctgcacgcct ttgagaatct   2040

ggagatcatc cggggcagaa caaagcagca cggccagttc tccctggccg tggtgtctct   2100

gaacatcacc agcctgggcc tgaggtccct gaaggagatc tctgacggcg atgtgatcat   2160

ctccggcaac aagaacctgt gctacgccaa cacaatcaat tggaagaagc tgtttggcac   2220

ctctggccag aagacaaaga tcatctctaa ccggggcgag aatagctgca aggcaaccgg   2280

acaggtgtgc cacgcactgt gcagcccaga gggatgttgg ggcccagagc cacgggactg   2340

cgtgagctgt agaaacgtgt ccaggggccg cgagtgcgtg gataagtgta atctgctgga   2400

gggcgagcca agggagttcg tggagaactc cgagtgcatc cagtgtcacc ccgagtgcct   2460

gcctcaggcc atgaacatca cctgtacagg ccgcggcccc gacaattgca tccagtgtgc   2520

ccactatatc gatggccctc actgcgtgaa gacctgtcca gccggcgtga tgggcgagaa   2580

caatacactg gtgtggaagt acgcagacgc aggacacgtg tgccacctgt gccaccccaa   2640

ttgcacctat ggctgtacag gaccaggcct ggagggatgc ccaaccaacg gccctaagat   2700

cccaagcatc gccacaggca tggtgggggc actgctgctg ctgctggtgg tggctctggg   2760

gattgggctg tttatgagaa ggtaatccta ctgcgaattc tcgagcgact gtgccttcta   2820

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca   2880

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc   2940

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata   3000

gcaggcatgc tggggatgcg gtgggctcta tgggtcgacc aaggtcgggc aggaagaggg   3060

cctatttccc atgattcctt catatttgca tatacgatac aaggctgtta gagagataat   3120

tagaattaat ttgactgtaa acacaaagat attagtacaa aatacgtgac gtagaaagta   3180

ataatttctt gggtagtttg cagttttaaa attatgtttt aaaatggact atcatatgct   3240

taccgtaact tgaaagtatt tcgatttctt ggctttatat atcttgtgga aaggactccc   3300

caacacgcac ttccgcacat tcttcaagag agaatgtgcg gaagtgcgtg ttttttt      3357


<210>  148
<211>  1638
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD-TM)-CD28 (IC)-CD3zeta -pA-U6-shPD1

<400>  148
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc    480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc    540

ctggtgctgc tagtctgggt cctggccgtc atcagtaaga ggagcaggct cctgcacagt    600

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat    660

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac    720

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    780

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    840

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    900

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    960

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1020

ccccctcgct aaaagcttgg taccctcgag gttaacgaat tctcctactg cgaattctcg   1080

agcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt   1140

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca   1200

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga   1260

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg gtcgaccaag   1320

gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag   1380

gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat   1440

acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa   1500

atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc   1560

ttgtggaaag gacgaaacac ctccccaggc gcagatcaaa gagagttcaa gagactctct   1620

ttgatctgcg cctttttt                                                 1638


<210>  149
<211>  1630
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD-TM)-CD28 (IC)-CD3zeta-pA-U6-sh CTLA4

<400>  149
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc    480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc    540

ctggtgctgc tagtctgggt cctggccgtc atcagtaaga ggagcaggct cctgcacagt    600

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat    660

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac    720

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    780

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    840

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    900

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    960

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1020

ccccctcgct aaaagcttgg taccctcgag gttaacgaat tctcctactg cgaattctcg   1080

agcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt   1140

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca   1200

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga   1260

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg gtcgaccaag   1320

gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag   1380

gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat   1440

acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa   1500

atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc   1560

ttgtggaaag gactccccgc atcacttggg attaatattc aagagatatt aatcccaagt   1620

gatgcttttt                                                          1630


<210>  150
<211>  1634
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD-TM)-CD28 (IC)-CD3zeta -pA-U6-sh CBL-B

<400>  150
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc    480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc    540

ctggtgctgc tagtctgggt cctggccgtc atcagtaaga ggagcaggct cctgcacagt    600

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat    660

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac    720

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    780

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    840

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    900

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    960

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1020

ccccctcgct aaaagcttgg taccctcgag gttaacgaat tctcctactg cgaattctcg   1080

agcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt   1140

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca   1200

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga   1260

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg gtcgaccaag   1320

gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag   1380

gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat   1440

acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa   1500

atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc   1560

ttgtggaaag gactccccaa cacagacgcc atgatttgct tcaagagagc aaatcatggc   1620

gtctgtgttt tttt                                                     1634


<210>  151
<211>  1634
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD-TM)-CD28 (IC)-CD3zeta-pA-U6-sh SOCS1

<400>  151
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc    480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc    540

ctggtgctgc tagtctgggt cctggccgtc atcagtaaga ggagcaggct cctgcacagt    600

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat    660

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac    720

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga    780

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg    840

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag    900

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt    960

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg   1020

ccccctcgct aaaagcttgg taccctcgag gttaacgaat tctcctactg cgaattctcg   1080

agcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt   1140

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca   1200

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga   1260

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg gtcgaccaag   1320

gtcgggcagg aagagggcct atttcccatg attccttcat atttgcatat acgatacaag   1380

gctgttagag agataattag aattaatttg actgtaaaca caaagatatt agtacaaaat   1440

acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa   1500

atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc   1560

ttgtggaaag gactccccaa cacgcacttc cgcacattct tcaagagaga atgtgcggaa   1620

gtgcgtgttt tttt                                                     1634


<210>  152
<211>  1673
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD)-CD28 (TM-IC)-CD3zeta -pA-U6-sh PD1

<400>  152
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacccaag tcccctattt    480

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat    540

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc    600

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac    660

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg    720

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta    780

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg    840

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag    900

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac    960

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg   1020

caggccctgc cccctcgcta aaagcttggt accctcgagg ttaacgaatt cgaatttaaa   1080

tcggatccgc ggccgcgtcc tactgcgaat tctcgagcga ctgtgccttc tagttgccag   1140

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact   1200

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt   1260

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat   1320

gctggggatg cggtgggctc tatgggtcga ccaaggtcgg gcaggaagag ggcctatttc   1380

ccatgattcc ttcatatttg catatacgat acaaggctgt tagagagata attagaatta   1440

atttgactgt aaacacaaag atattagtac aaaatacgtg acgtagaaag taataatttc   1500

ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga ctatcatatg cttaccgtaa   1560

cttgaaagta tttcgatttc ttggctttat atatcttgtg gaaaggacga aacacctccc   1620

caggcgcaga tcaaagagag ttcaagagac tctctttgat ctgcgccttt ttt          1673


<210>  153
<211>  1665
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD)-CD28 (TM-IC)-CD3zeta -pA-U6-sh CTLA4

<400>  153
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacccaag tcccctattt    480

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat    540

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc    600

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac    660

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg    720

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta    780

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg    840

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag    900

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac    960

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg   1020

caggccctgc cccctcgcta aaagcttggt accctcgagg ttaacgaatt cgaatttaaa   1080

tcggatccgc ggccgcgtcc tactgcgaat tctcgagcga ctgtgccttc tagttgccag   1140

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact   1200

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt   1260

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat   1320

gctggggatg cggtgggctc tatgggtcga ccaaggtcgg gcaggaagag ggcctatttc   1380

ccatgattcc ttcatatttg catatacgat acaaggctgt tagagagata attagaatta   1440

atttgactgt aaacacaaag atattagtac aaaatacgtg acgtagaaag taataatttc   1500

ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga ctatcatatg cttaccgtaa   1560

cttgaaagta tttcgatttc ttggctttat atatcttgtg gaaaggactc cccgcatcac   1620

ttgggattaa tattcaagag atattaatcc caagtgatgc ttttt                   1665


<210>  154
<211>  1669
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD)-CD28 (TM-IC)-CD3zeta -pA-U6-sh CBL-B

<400>  154
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacccaag tcccctattt    480

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat    540

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc    600

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac    660

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg    720

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta    780

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg    840

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag    900

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac    960

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg   1020

caggccctgc cccctcgcta aaagcttggt accctcgagg ttaacgaatt cgaatttaaa   1080

tcggatccgc ggccgcgtcc tactgcgaat tctcgagcga ctgtgccttc tagttgccag   1140

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact   1200

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt   1260

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat   1320

gctggggatg cggtgggctc tatgggtcga ccaaggtcgg gcaggaagag ggcctatttc   1380

ccatgattcc ttcatatttg catatacgat acaaggctgt tagagagata attagaatta   1440

atttgactgt aaacacaaag atattagtac aaaatacgtg acgtagaaag taataatttc   1500

ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga ctatcatatg cttaccgtaa   1560

cttgaaagta tttcgatttc ttggctttat atatcttgtg gaaaggactc cccaacacag   1620

acgccatgat ttgcttcaag agagcaaatc atggcgtctg tgttttttt               1669


<210>  155
<211>  1669
<212>  DNA
<213>  Artificial

<220>
<223>  PD1(ECD)-CD28(TM-IC)-CD3zeta -pA-U6-shSOCS1

<400>  155
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg     60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc    120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg    180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc    240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg    300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc    360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca    420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacccaag tcccctattt    480

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat    540

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc    600

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac    660

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccagagtgaa gttcagcagg    720

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta    780

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg    840

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag    900

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac    960

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg   1020

caggccctgc cccctcgcta aaagcttggt accctcgagg ttaacgaatt cgaatttaaa   1080

tcggatccgc ggccgcgtcc tactgcgaat tctcgagcga ctgtgccttc tagttgccag   1140

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact   1200

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt   1260

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat   1320

gctggggatg cggtgggctc tatgggtcga ccaaggtcgg gcaggaagag ggcctatttc   1380

ccatgattcc ttcatatttg catatacgat acaaggctgt tagagagata attagaatta   1440

atttgactgt aaacacaaag atattagtac aaaatacgtg acgtagaaag taataatttc   1500

ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga ctatcatatg cttaccgtaa   1560

cttgaaagta tttcgatttc ttggctttat atatcttgtg gaaaggactc cccaacacgc   1620

acttccgcac attcttcaag agagaatgtg cggaagtgcg tgttttttt               1669


<210>  156
<211>  587
<212>  DNA
<213>  Artificial

<220>
<223>  ڲĺ

<400>  156
cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg     60

tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg    120

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg    180

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca    240

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct    300

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca    360

cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa    420

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg    480

cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg    540

ggacgtggtt ttcctttgaa aaacacgatg ataatatggc cacaacc                  587


<210>  157
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  ĵİ

<400>  157

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  158
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  ĵİ

<400>  158

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  159
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  ĵİ

<400>  159

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  160
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  ĵİ

<400>  160

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


