                         SEQUENCE LISTING

<110>  Alma Mater Studiorum Universita di Bologna
       Ciani, Elisabetta
       Laccone, Franco
 
<120>  TATk-CDKL5 Fusion Proteins, Compositions, Formulations, and Use 
       Thereof

<130>  ACS0052-00WO

<150>  US 62/355,579
<151>  2016-06-28

<150>  US 62/381,886
<151>  2016-08-31

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  3087
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKL5 115 isoform cDNA

<400>  1
aagattccta acattggtaa tgtgatgaat aaatttgaga tccttggggt tgtaggtgaa       60

ggagcctatg gagttgtact taaatgcaga cacaaggaaa cacatgaaat tgtggcgatc      120

aagaaattca aggacagtga agaaaatgaa gaagtcaaag aaacgacttt acgagagctt      180

aaaatgcttc ggactctcaa gcaggaaaac attgtggagt tgaaggaagc atttcgtcgg      240

aggggaaagt tgtacttggt gtttgagtat gttgaaaaaa atatgctcga attgctggaa      300

gaaatgccaa atggagttcc acctgagaaa gtaaaaagct acatctatca gctaatcaag      360

gctattcact ggtgccataa gaatgatatt gtccatcgag atataaaacc agaaaatctc      420

ttaatcagcc acaatgatgt cctaaaactg tgtgactttg gttttgctcg taatctgtca      480

gaaggcaata atgctaatta cacagagtac gttgccacca gatggtatcg gtccccagaa      540

ctcttacttg gcgctcccta tggaaagtcc gtggacatgt ggtcggtggg ctgtattctt      600

ggggagctta gcgatggaca gcctttattt cctggagaaa gtgaaattga ccaacttttt      660

actattcaga aggtgctagg accacttcca tctgagcaga tgaagctttt ctacagtaat      720

cctcgcttcc atgggctccg gtttccagct gttaaccatc ctcagtcctt ggaaagaaga      780

taccttggaa ttttgaatag tgttctactt gacctaatga agaatttact gaagttggac      840

ccagctgaca gatacttgac agaacagtgt ttgaatcacc ctacatttca aacccagaga      900

cttctggatc gttctccttc aaggtcagca aaaagaaaac cttaccatgt ggaaagcagc      960

acattgtcta atagaaacca agccggcaaa agtactgctt tgcagtctca ccacagatct     1020

aacagcaagg acatccagaa cctgagtgta ggcctgcccc gggctgacga aggtctccct     1080

gccaatgaaa gcttcctaaa tggaaacctt gctggagcta gtcttagtcc actgcacacc     1140

aaaacctacc aagcaagcag ccagcctggg tctaccagca aagatctcac caacaacaac     1200

ataccacacc ttcttagccc aaaagaagcc aagtcaaaaa cagagtttga ttttaatatt     1260

gacccaaagc cttcagaagg cccagggaca aagtacctca agtcaaacag cagatctcag     1320

cagaaccgcc actcattcat ggaaagctct caaagcaaag ctgggacact gcagcccaat     1380

gaaaagcaga gtcggcatag ctatattgac acaattcccc agtcctctag gagtccctcc     1440

tacaggacca aggccaaaag ccatggggca ctgagtgact ccaagtctgt gagcaacctt     1500

tctgaagcca gggcccaaat tgcggagccc agtaccagta ggtacttccc atctagctgc     1560

ttagacttga attctcccac cagcccaacc cccaccagac acagtgacac gagaactttg     1620

ctcagccctt ctggaagaaa taaccgaaat gagggaacgc tggactcacg tcgaaccaca     1680

accagacatt ctaagacgat ggaggaattg aagctgccgg agcacatgga cagtagccat     1740

tcccattcac tgtctgcacc tcacgaatct ttttcttatg gactgggcta caccagcccc     1800

ttttcttccc agcaacgtcc tcataggcat tctatgtatg tgacccgtga caaagtgaga     1860

gccaagggct tggatggaag cttgagcata gggcaaggga tggcagctag agccaacagc     1920

ctgcaactct tgtcacccca gcctggagaa cagctccctc cagagatgac tgtggcaaga     1980

tcttcggtca aagagacctc cagagaaggc acctcttcct tccatacacg ccagaagtct     2040

gagggtggag tgtatcatga cccacactct gatgatggca cagcccccaa agaaaataga     2100

cacctataca atgatcctgt gccaaggaga gttggtagct tttacagagt gccatctcca     2160

cgtccagaca attctttcca tgaaaataat gtgtcaacta gagtttcttc tctaccatca     2220

gagagcagtt ctggaaccaa ccactcaaaa agacaaccag cattcgatcc atggaaaagt     2280

cctgaaaata ttagtcattc agagcaactc aaggaaaaag agaagcaagg atttttcagg     2340

tcaatgaaaa agaaaaagaa gaaatctcaa acagtaccca attccgacag ccctgatctt     2400

ctgacgttgc agaaatccat tcattctgct agcactccaa gcagcagacc aaaggagtgg     2460

cgccccgaga agatctcaga tctgcagacc caaagccagc cattaaaatc actgcgcaag     2520

ttgttacatc tctcttcggc ctcaaatcac ccggcttcct cagatccccg cttccagccc     2580

ttaacagctc aacaaaccaa aaattccttc tcagaaattc ggattcaccc cctgagccag     2640

gcctctggcg ggagcagcaa catccggcag gaacccgcac cgaagggcag gccagccctc     2700

cagctgccag acggtggatg tgatggcaga agacagagac accattctgg accccaagat     2760

agacgcttca tgttaaggac gacagaacaa caaggagaat acttctgctg tggtgaccca     2820

aagaagcctc acactccgtg cgtcccaaac cgagcccttc atcgtccaat ctccagtcct     2880

gctccctatc cagtactcca ggtccgaggc acttccatgt gcccgacact ccaggtccga     2940

ggcactgatg ctttcagctg cccaacccag caatccgggt tctctttctt cgtgagacac     3000

gttatgaggg aagccctgat tcacagggcc caggtaaacc aagctgcgct cctgacatac     3060

catgagaatg cggcactgac gggcaag                                         3087


<210>  2
<211>  1029
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL5 isoform 115 polypeptide

<400>  2

Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu Gly 
1               5                   10                  15      


Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His Lys 
            20                  25                  30          


Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu Glu 
        35                  40                  45              


Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu Arg 
    50                  55                  60                  


Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg Arg 
65                  70                  75                  80  


Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met Leu 
                85                  90                  95      


Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val Lys 
            100                 105                 110         


Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys Asn 
        115                 120                 125             


Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser His 
    130                 135                 140                 


Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu Ser 
145                 150                 155                 160 


Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp Tyr 
                165                 170                 175     


Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val Asp 
            180                 185                 190         


Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln Pro 
        195                 200                 205             


Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln Lys 
    210                 215                 220                 


Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser Asn 
225                 230                 235                 240 


Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln Ser 
                245                 250                 255     


Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp Leu 
            260                 265                 270         


Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr Glu 
        275                 280                 285             


Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp Arg 
    290                 295                 300                 


Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser Ser 
305                 310                 315                 320 


Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser 
                325                 330                 335     


His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly Leu 
            340                 345                 350         


Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly 
        355                 360                 365             


Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr Gln 
    370                 375                 380                 


Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn 
385                 390                 395                 400 


Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe 
                405                 410                 415     


Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr 
            420                 425                 430         


Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met Glu 
        435                 440                 445             


Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser 
    450                 455                 460                 


Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser 
465                 470                 475                 480 


Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys Ser 
                485                 490                 495     


Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr 
            500                 505                 510         


Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser 
        515                 520                 525             


Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser 
    530                 535                 540                 


Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr 
545                 550                 555                 560 


Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His Met 
                565                 570                 575     


Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe Ser 
            580                 585                 590         


Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro His 
        595                 600                 605             


Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly Leu 
    610                 615                 620                 


Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn Ser 
625                 630                 635                 640 


Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu Met 
                645                 650                 655     


Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr Ser 
            660                 665                 670         


Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp Pro 
        675                 680                 685             


His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr Asn 
    690                 695                 700                 


Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser Pro 
705                 710                 715                 720 


Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val Ser 
                725                 730                 735     


Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg Gln 
            740                 745                 750         


Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser Glu 
        755                 760                 765             


Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys Lys 
    770                 775                 780                 


Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp Leu 
785                 790                 795                 800 


Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser Arg 
                805                 810                 815     


Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln Ser 
            820                 825                 830         


Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala Ser 
        835                 840                 845             


Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala Gln 
    850                 855                 860                 


Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser Gln 
865                 870                 875                 880 


Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys Gly 
                885                 890                 895     


Arg Pro Ala Leu Gln Leu Pro Asp Gly Gly Cys Asp Gly Arg Arg Gln 
            900                 905                 910         


Arg His His Ser Gly Pro Gln Asp Arg Arg Phe Met Leu Arg Thr Thr 
        915                 920                 925             


Glu Gln Gln Gly Glu Tyr Phe Cys Cys Gly Asp Pro Lys Lys Pro His 
    930                 935                 940                 


Thr Pro Cys Val Pro Asn Arg Ala Leu His Arg Pro Ile Ser Ser Pro 
945                 950                 955                 960 


Ala Pro Tyr Pro Val Leu Gln Val Arg Gly Thr Ser Met Cys Pro Thr 
                965                 970                 975     


Leu Gln Val Arg Gly Thr Asp Ala Phe Ser Cys Pro Thr Gln Gln Ser 
            980                 985                 990         


Gly Phe Ser Phe Phe Val Arg His  Val Met Arg Glu Ala  Leu Ile His 
        995                 1000                 1005             


Arg Ala  Gln Val Asn Gln Ala  Ala Leu Leu Thr Tyr  His Glu Asn 
    1010                 1015                 1020             


Ala Ala  Leu Thr Gly Lys 
    1025                 


<210>  3
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TATk polynucleotide

<400>  3
tacgccagaa aggccgccag gcaggccagg gca                                    33


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TATk polypeptide

<400>  4

Tyr Ala Arg Lys Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  5
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Igk-chain leader polynucleotide

<400>  5
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Igk-chain leader polypeptide

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  7
<211>  3318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKL5 115 isoform fusion protein polynucleotide

<400>  7
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacgcggccc agccggccag gcgcgcgcgc cgtacgaagc ttgcggccta cgccagaaag      120

gccgccaggc aggccagggc accggtgaag attcctaaca ttggtaatgt gatgaataaa      180

tttgagatcc ttggggttgt aggtgaagga gcctatggag ttgtacttaa atgcagacac      240

aaggaaacac atgaaattgt ggcgatcaag aaattcaagg acagtgaaga aaatgaagaa      300

gtcaaagaaa cgactttacg agagcttaaa atgcttcgga ctctcaagca ggaaaacatt      360

gtggagttga aggaagcatt tcgtcggagg ggaaagttgt acttggtgtt tgagtatgtt      420

gaaaaaaata tgctcgaatt gctggaagaa atgccaaatg gagttccacc tgagaaagta      480

aaaagctaca tctatcagct aatcaaggct attcactggt gccataagaa tgatattgtc      540

catcgagata taaaaccaga aaatctctta atcagccaca atgatgtcct aaaactgtgt      600

gactttggtt ttgctcgtaa tctgtcagaa ggcaataatg ctaattacac agagtacgtt      660

gccaccagat ggtatcggtc cccagaactc ttacttggcg ctccctatgg aaagtccgtg      720

gacatgtggt cggtgggctg tattcttggg gagcttagcg atggacagcc tttatttcct      780

ggagaaagtg aaattgacca actttttact attcagaagg tgctaggacc acttccatct      840

gagcagatga agcttttcta cagtaatcct cgcttccatg ggctccggtt tccagctgtt      900

aaccatcctc agtccttgga aagaagatac cttggaattt tgaatagtgt tctacttgac      960

ctaatgaaga atttactgaa gttggaccca gctgacagat acttgacaga acagtgtttg     1020

aatcacccta catttcaaac ccagagactt ctggatcgtt ctccttcaag gtcagcaaaa     1080

agaaaacctt accatgtgga aagcagcaca ttgtctaata gaaaccaagc cggcaaaagt     1140

actgctttgc agtctcacca cagatctaac agcaaggaca tccagaacct gagtgtaggc     1200

ctgccccggg ctgacgaagg tctccctgcc aatgaaagct tcctaaatgg aaaccttgct     1260

ggagctagtc ttagtccact gcacaccaaa acctaccaag caagcagcca gcctgggtct     1320

accagcaaag atctcaccaa caacaacata ccacaccttc ttagcccaaa agaagccaag     1380

tcaaaaacag agtttgattt taatattgac ccaaagcctt cagaaggccc agggacaaag     1440

tacctcaagt caaacagcag atctcagcag aaccgccact cattcatgga aagctctcaa     1500

agcaaagctg ggacactgca gcccaatgaa aagcagagtc ggcatagcta tattgacaca     1560

attccccagt cctctaggag tccctcctac aggaccaagg ccaaaagcca tggggcactg     1620

agtgactcca agtctgtgag caacctttct gaagccaggg cccaaattgc ggagcccagt     1680

accagtaggt acttcccatc tagctgctta gacttgaatt ctcccaccag cccaaccccc     1740

accagacaca gtgacacgag aactttgctc agcccttctg gaagaaataa ccgaaatgag     1800

ggaacgctgg actcacgtcg aaccacaacc agacattcta agacgatgga ggaattgaag     1860

ctgccggagc acatggacag tagccattcc cattcactgt ctgcacctca cgaatctttt     1920

tcttatggac tgggctacac cagccccttt tcttcccagc aacgtcctca taggcattct     1980

atgtatgtga cccgtgacaa agtgagagcc aagggcttgg atggaagctt gagcataggg     2040

caagggatgg cagctagagc caacagcctg caactcttgt caccccagcc tggagaacag     2100

ctccctccag agatgactgt ggcaagatct tcggtcaaag agacctccag agaaggcacc     2160

tcttccttcc atacacgcca gaagtctgag ggtggagtgt atcatgaccc acactctgat     2220

gatggcacag cccccaaaga aaatagacac ctatacaatg atcctgtgcc aaggagagtt     2280

ggtagctttt acagagtgcc atctccacgt ccagacaatt ctttccatga aaataatgtg     2340

tcaactagag tttcttctct accatcagag agcagttctg gaaccaacca ctcaaaaaga     2400

caaccagcat tcgatccatg gaaaagtcct gaaaatatta gtcattcaga gcaactcaag     2460

gaaaaagaga agcaaggatt tttcaggtca atgaaaaaga aaaagaagaa atctcaaaca     2520

gtacccaatt ccgacagccc tgatcttctg acgttgcaga aatccattca ttctgctagc     2580

actccaagca gcagaccaaa ggagtggcgc cccgagaaga tctcagatct gcagacccaa     2640

agccagccat taaaatcact gcgcaagttg ttacatctct cttcggcctc aaatcacccg     2700

gcttcctcag atccccgctt ccagccctta acagctcaac aaaccaaaaa ttccttctca     2760

gaaattcgga ttcaccccct gagccaggcc tctggcggga gcagcaacat ccggcaggaa     2820

cccgcaccga agggcaggcc agccctccag ctgccagacg gtggatgtga tggcagaaga     2880

cagagacacc attctggacc ccaagataga cgcttcatgt taaggacgac agaacaacaa     2940

ggagaatact tctgctgtgg tgacccaaag aagcctcaca ctccgtgcgt cccaaaccga     3000

gcccttcatc gtccaatctc cagtcctgct ccctatccag tactccaggt ccgaggcact     3060

tccatgtgcc cgacactcca ggtccgaggc actgatgctt tcagctgccc aacccagcaa     3120

tccgggttct ctttcttcgt gagacacgtt atgagggaag ccctgattca cagggcccag     3180

gtaaaccaag ctgcgctcct gacataccat gagaatgcgg cactgacggg caagtccgct     3240

cgaggagggc ccgaacaaaa actcatctca gaagaggatc tgaatagcgc cgtcgaccat     3300

catcatcatc atcattga                                                   3318


<210>  8
<211>  1105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL5 115 isoform fusion protein polypeptide

<400>  8

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Ala Ala Tyr Ala Arg Lys Ala Ala Arg Gln Ala Arg Ala Pro 
        35                  40                  45              


Val Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
    50                  55                  60                  


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
65                  70                  75                  80  


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
                85                  90                  95      


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
            100                 105                 110         


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
        115                 120                 125             


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
    130                 135                 140                 


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
145                 150                 155                 160 


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
                165                 170                 175     


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
            180                 185                 190         


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
        195                 200                 205             


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
    210                 215                 220                 


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
225                 230                 235                 240 


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
                245                 250                 255     


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
            260                 265                 270         


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
        275                 280                 285             


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
    290                 295                 300                 


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
305                 310                 315                 320 


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
                325                 330                 335     


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
            340                 345                 350         


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
        355                 360                 365             


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
    370                 375                 380                 


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
385                 390                 395                 400 


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
                405                 410                 415     


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
            420                 425                 430         


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
        435                 440                 445             


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
    450                 455                 460                 


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
465                 470                 475                 480 


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
                485                 490                 495     


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
            500                 505                 510         


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
        515                 520                 525             


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
    530                 535                 540                 


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
545                 550                 555                 560 


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
                565                 570                 575     


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
            580                 585                 590         


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
        595                 600                 605             


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
    610                 615                 620                 


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
625                 630                 635                 640 


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
                645                 650                 655     


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
            660                 665                 670         


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
        675                 680                 685             


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
    690                 695                 700                 


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
705                 710                 715                 720 


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
                725                 730                 735     


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
            740                 745                 750         


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
        755                 760                 765             


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
    770                 775                 780                 


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
785                 790                 795                 800 


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
                805                 810                 815     


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
            820                 825                 830         


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
        835                 840                 845             


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
    850                 855                 860                 


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
865                 870                 875                 880 


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
                885                 890                 895     


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
            900                 905                 910         


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
        915                 920                 925             


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
    930                 935                 940                 


Gly Arg Pro Ala Leu Gln Leu Pro Asp Gly Gly Cys Asp Gly Arg Arg 
945                 950                 955                 960 


Gln Arg His His Ser Gly Pro Gln Asp Arg Arg Phe Met Leu Arg Thr 
                965                 970                 975     


Thr Glu Gln Gln Gly Glu Tyr Phe Cys Cys Gly Asp Pro Lys Lys Pro 
            980                 985                 990         


His Thr Pro Cys Val Pro Asn Arg  Ala Leu His Arg Pro  Ile Ser Ser 
        995                 1000                 1005             


Pro Ala  Pro Tyr Pro Val Leu  Gln Val Arg Gly Thr  Ser Met Cys 
    1010                 1015                 1020             


Pro Thr  Leu Gln Val Arg Gly  Thr Asp Ala Phe Ser  Cys Pro Thr 
    1025                 1030                 1035             


Gln Gln  Ser Gly Phe Ser Phe  Phe Val Arg His Val  Met Arg Glu 
    1040                 1045                 1050             


Ala Leu  Ile His Arg Ala Gln  Val Asn Gln Ala Ala  Leu Leu Thr 
    1055                 1060                 1065             


Tyr His  Glu Asn Ala Ala Leu  Thr Gly Lys Ser Ala  Arg Gly Gly 
    1070                 1075                 1080             


Pro Glu  Gln Lys Leu Ile Ser  Glu Glu Asp Leu Asn  Ser Ala Val 
    1085                 1090                 1095             


Asp His  His His His His His  
    1100                 1105 


<210>  9
<211>  4072
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKL5 115 isoform fusion protein polynucleotide


<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  methionine initiator codon

<400>  9
gctagccacc atggagacag acacactcct gctatgggta ctgctgctct gggttccagg       60

ttccactggt gacgcggccc agccggccag gcgcgcgcgc cgtacgaagc ttgcggccta      120

cgccagaaag gccgccaggc aggccagggc accggtcgcc accatggtga gcaagggcga      180

ggagctgttc accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca      240

caagttcagc gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa      300

gttcatctgc accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac      360

ctacggcgtg cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa      420

gtccgccatg cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa      480

ctacaagacc cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct      540

gaagggcatc gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta      600

caacagccac aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt      660

caagatccgc cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa      720

cacccccatc ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc      780

cgccctgagc aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac      840

cgccgccggg atcactctcg gcatggacga gctgtacaag tccggactca gatctcgagc      900

gaagattcct aacattggta atgtgatgaa taaatttgag atccttgggg ttgtaggtga      960

aggagcctat ggagttgtac ttaaatgcag acacaaggaa acacatgaaa ttgtggcgat     1020

caagaaattc aaggacagtg aagaaaatga agaagtcaaa gaaacgactt tacgagagct     1080

taaaatgctt cggactctca agcaggaaaa cattgtggag ttgaaggaag catttcgtcg     1140

gaggggaaag ttgtacttgg tgtttgagta tgttgaaaaa aatatgctcg aattgctgga     1200

agaaatgcca aatggagttc cacctgagaa agtaaaaagc tacatctatc agctaatcaa     1260

ggctattcac tggtgccata agaatgatat tgtccatcga gatataaaac cagaaaatct     1320

cttaatcagc cacaatgatg tcctaaaact gtgtgacttt ggttttgctc gtaatctgtc     1380

agaaggcaat aatgctaatt acacagagta cgttgccacc agatggtatc ggtccccaga     1440

actcttactt ggcgctccct atggaaagtc cgtggacatg tggtcggtgg gctgtattct     1500

tggggagctt agcgatggac agcctttatt tcctggagaa agtgaaattg accaactttt     1560

tactattcag aaggtgctag gaccacttcc atctgagcag atgaagcttt tctacagtaa     1620

tcctcgcttc catgggctcc ggtttccagc tgttaaccat cctcagtcct tggaaagaag     1680

ataccttgga attttgaata gtgttctact tgacctaatg aagaatttac tgaagttgga     1740

cccagctgac agatacttga cagaacagtg tttgaatcac cctacatttc aaacccagag     1800

acttctggat cgttctcctt caaggtcagc aaaaagaaaa ccttaccatg tggaaagcag     1860

cacattgtct aatagaaacc aagccggcaa aagtactgct ttgcagtctc accacagatc     1920

taacagcaag gacatccaga acctgagtgt aggcctgccc cgggctgacg aaggtctccc     1980

tgccaatgaa agcttcctaa atggaaacct tgctggagct agtcttagtc cactgcacac     2040

caaaacctac caagcaagca gccagcctgg gtctaccagc aaagatctca ccaacaacaa     2100

cataccacac cttcttagcc caaaagaagc caagtcaaaa acagagtttg attttaatat     2160

tgacccaaag ccttcagaag gcccagggac aaagtacctc aagtcaaaca gcagatctca     2220

gcagaaccgc cactcattca tggaaagctc tcaaagcaaa gctgggacac tgcagcccaa     2280

tgaaaagcag agtcggcata gctatattga cacaattccc cagtcctcta ggagtccctc     2340

ctacaggacc aaggccaaaa gccatggggc actgagtgac tccaagtctg tgagcaacct     2400

ttctgaagcc agggcccaaa ttgcggagcc cagtaccagt aggtacttcc catctagctg     2460

cttagacttg aattctccca ccagcccaac ccccaccaga cacagtgaca cgagaacttt     2520

gctcagccct tctggaagaa ataaccgaaa tgagggaacg ctggactcac gtcgaaccac     2580

aaccagacat tctaagacga tggaggaatt gaagctgccg gagcacatgg acagtagcca     2640

ttcccattca ctgtctgcac ctcacgaatc tttttcttat ggactgggct acaccagccc     2700

cttttcttcc cagcaacgtc ctcataggca ttctatgtat gtgacccgtg acaaagtgag     2760

agccaagggc ttggatggaa gcttgagcat agggcaaggg atggcagcta gagccaacag     2820

cctgcaactc ttgtcacccc agcctggaga acagctccct ccagagatga ctgtggcaag     2880

atcttcggtc aaagagacct ccagagaagg cacctcttcc ttccatacac gccagaagtc     2940

tgagggtgga gtgtatcatg acccacactc tgatgatggc acagccccca aagaaaatag     3000

acacctatac aatgatcctg tgccaaggag agttggtagc ttttacagag tgccatctcc     3060

acgtccagac aattctttcc atgaaaataa tgtgtcaact agagtttctt ctctaccatc     3120

agagagcagt tctggaacca accactcaaa aagacaacca gcattcgatc catggaaaag     3180

tcctgaaaat attagtcatt cagagcaact caaggaaaaa gagaagcaag gatttttcag     3240

gtcaatgaaa aagaaaaaga agaaatctca aacagtaccc aattccgaca gccctgatct     3300

tctgacgttg cagaaatcca ttcattctgc tagcactcca agcagcagac caaaggagtg     3360

gcgccccgag aagatctcag atctgcagac ccaaagccag ccattaaaat cactgcgcaa     3420

gttgttacat ctctcttcgg cctcaaatca cccggcttcc tcagatcccc gcttccagcc     3480

cttaacagct caacaaacca aaaattcctt ctcagaaatt cggattcacc ccctgagcca     3540

ggcctctggc gggagcagca acatccggca ggaacccgca ccgaagggca ggccagccct     3600

ccagctgcca gacggtggat gtgatggcag aagacagaga caccattctg gaccccaaga     3660

tagacgcttc atgttaagga cgacagaaca acaaggagaa tacttctgct gtggtgaccc     3720

aaagaagcct cacactccgt gcgtcccaaa ccgagccctt catcgtccaa tctccagtcc     3780

tgctccctat ccagtactcc aggtccgagg cacttccatg tgcccgacac tccaggtccg     3840

aggcactgat gctttcagct gcccaaccca gcaatccggg ttctctttct tcgtgagaca     3900

cgttatgagg gaagccctga ttcacagggc ccaggtaaac caagctgcgc tcctgacata     3960

ccatgagaat gcggcactga cgggcaagtc cgctcgagga gggcccgaac aaaaactcat     4020

ctcagaagag gatctgaata gcgccgtcga ccatcatcat catcatcatt ga             4072


<210>  10
<211>  1353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL5 115 isoform fusion protein polypeptide

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Ala Ala Tyr Ala Arg Lys Ala Ala Arg Gln Ala Arg Ala Pro 
        35                  40                  45              


Val Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
    50                  55                  60                  


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
65                  70                  75                  80  


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
                85                  90                  95      


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
            100                 105                 110         


Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
        115                 120                 125             


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
    130                 135                 140                 


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
145                 150                 155                 160 


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
                165                 170                 175     


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
            180                 185                 190         


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
        195                 200                 205             


Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
    210                 215                 220                 


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
225                 230                 235                 240 


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
                245                 250                 255     


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
            260                 265                 270         


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
        275                 280                 285             


Tyr Lys Ser Gly Leu Arg Ser Arg Ala Lys Ile Pro Asn Ile Gly Asn 
    290                 295                 300                 


Val Met Asn Lys Phe Glu Ile Leu Gly Val Val Gly Glu Gly Ala Tyr 
305                 310                 315                 320 


Gly Val Val Leu Lys Cys Arg His Lys Glu Thr His Glu Ile Val Ala 
                325                 330                 335     


Ile Lys Lys Phe Lys Asp Ser Glu Glu Asn Glu Glu Val Lys Glu Thr 
            340                 345                 350         


Thr Leu Arg Glu Leu Lys Met Leu Arg Thr Leu Lys Gln Glu Asn Ile 
        355                 360                 365             


Val Glu Leu Lys Glu Ala Phe Arg Arg Arg Gly Lys Leu Tyr Leu Val 
    370                 375                 380                 


Phe Glu Tyr Val Glu Lys Asn Met Leu Glu Leu Leu Glu Glu Met Pro 
385                 390                 395                 400 


Asn Gly Val Pro Pro Glu Lys Val Lys Ser Tyr Ile Tyr Gln Leu Ile 
                405                 410                 415     


Lys Ala Ile His Trp Cys His Lys Asn Asp Ile Val His Arg Asp Ile 
            420                 425                 430         


Lys Pro Glu Asn Leu Leu Ile Ser His Asn Asp Val Leu Lys Leu Cys 
        435                 440                 445             


Asp Phe Gly Phe Ala Arg Asn Leu Ser Glu Gly Asn Asn Ala Asn Tyr 
    450                 455                 460                 


Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu Leu Leu 
465                 470                 475                 480 


Gly Ala Pro Tyr Gly Lys Ser Val Asp Met Trp Ser Val Gly Cys Ile 
                485                 490                 495     


Leu Gly Glu Leu Ser Asp Gly Gln Pro Leu Phe Pro Gly Glu Ser Glu 
            500                 505                 510         


Ile Asp Gln Leu Phe Thr Ile Gln Lys Val Leu Gly Pro Leu Pro Ser 
        515                 520                 525             


Glu Gln Met Lys Leu Phe Tyr Ser Asn Pro Arg Phe His Gly Leu Arg 
    530                 535                 540                 


Phe Pro Ala Val Asn His Pro Gln Ser Leu Glu Arg Arg Tyr Leu Gly 
545                 550                 555                 560 


Ile Leu Asn Ser Val Leu Leu Asp Leu Met Lys Asn Leu Leu Lys Leu 
                565                 570                 575     


Asp Pro Ala Asp Arg Tyr Leu Thr Glu Gln Cys Leu Asn His Pro Thr 
            580                 585                 590         


Phe Gln Thr Gln Arg Leu Leu Asp Arg Ser Pro Ser Arg Ser Ala Lys 
        595                 600                 605             


Arg Lys Pro Tyr His Val Glu Ser Ser Thr Leu Ser Asn Arg Asn Gln 
    610                 615                 620                 


Ala Gly Lys Ser Thr Ala Leu Gln Ser His His Arg Ser Asn Ser Lys 
625                 630                 635                 640 


Asp Ile Gln Asn Leu Ser Val Gly Leu Pro Arg Ala Asp Glu Gly Leu 
                645                 650                 655     


Pro Ala Asn Glu Ser Phe Leu Asn Gly Asn Leu Ala Gly Ala Ser Leu 
            660                 665                 670         


Ser Pro Leu His Thr Lys Thr Tyr Gln Ala Ser Ser Gln Pro Gly Ser 
        675                 680                 685             


Thr Ser Lys Asp Leu Thr Asn Asn Asn Ile Pro His Leu Leu Ser Pro 
    690                 695                 700                 


Lys Glu Ala Lys Ser Lys Thr Glu Phe Asp Phe Asn Ile Asp Pro Lys 
705                 710                 715                 720 


Pro Ser Glu Gly Pro Gly Thr Lys Tyr Leu Lys Ser Asn Ser Arg Ser 
                725                 730                 735     


Gln Gln Asn Arg His Ser Phe Met Glu Ser Ser Gln Ser Lys Ala Gly 
            740                 745                 750         


Thr Leu Gln Pro Asn Glu Lys Gln Ser Arg His Ser Tyr Ile Asp Thr 
        755                 760                 765             


Ile Pro Gln Ser Ser Arg Ser Pro Ser Tyr Arg Thr Lys Ala Lys Ser 
    770                 775                 780                 


His Gly Ala Leu Ser Asp Ser Lys Ser Val Ser Asn Leu Ser Glu Ala 
785                 790                 795                 800 


Arg Ala Gln Ile Ala Glu Pro Ser Thr Ser Arg Tyr Phe Pro Ser Ser 
                805                 810                 815     


Cys Leu Asp Leu Asn Ser Pro Thr Ser Pro Thr Pro Thr Arg His Ser 
            820                 825                 830         


Asp Thr Arg Thr Leu Leu Ser Pro Ser Gly Arg Asn Asn Arg Asn Glu 
        835                 840                 845             


Gly Thr Leu Asp Ser Arg Arg Thr Thr Thr Arg His Ser Lys Thr Met 
    850                 855                 860                 


Glu Glu Leu Lys Leu Pro Glu His Met Asp Ser Ser His Ser His Ser 
865                 870                 875                 880 


Leu Ser Ala Pro His Glu Ser Phe Ser Tyr Gly Leu Gly Tyr Thr Ser 
                885                 890                 895     


Pro Phe Ser Ser Gln Gln Arg Pro His Arg His Ser Met Tyr Val Thr 
            900                 905                 910         


Arg Asp Lys Val Arg Ala Lys Gly Leu Asp Gly Ser Leu Ser Ile Gly 
        915                 920                 925             


Gln Gly Met Ala Ala Arg Ala Asn Ser Leu Gln Leu Leu Ser Pro Gln 
    930                 935                 940                 


Pro Gly Glu Gln Leu Pro Pro Glu Met Thr Val Ala Arg Ser Ser Val 
945                 950                 955                 960 


Lys Glu Thr Ser Arg Glu Gly Thr Ser Ser Phe His Thr Arg Gln Lys 
                965                 970                 975     


Ser Glu Gly Gly Val Tyr His Asp Pro His Ser Asp Asp Gly Thr Ala 
            980                 985                 990         


Pro Lys Glu Asn Arg His Leu Tyr  Asn Asp Pro Val Pro  Arg Arg Val 
        995                 1000                 1005             


Gly Ser  Phe Tyr Arg Val Pro  Ser Pro Arg Pro Asp  Asn Ser Phe 
    1010                 1015                 1020             


His Glu  Asn Asn Val Ser Thr  Arg Val Ser Ser Leu  Pro Ser Glu 
    1025                 1030                 1035             


Ser Ser  Ser Gly Thr Asn His  Ser Lys Arg Gln Pro  Ala Phe Asp 
    1040                 1045                 1050             


Pro Trp  Lys Ser Pro Glu Asn  Ile Ser His Ser Glu  Gln Leu Lys 
    1055                 1060                 1065             


Glu Lys  Glu Lys Gln Gly Phe  Phe Arg Ser Met Lys  Lys Lys Lys 
    1070                 1075                 1080             


Lys Lys  Ser Gln Thr Val Pro  Asn Ser Asp Ser Pro  Asp Leu Leu 
    1085                 1090                 1095             


Thr Leu  Gln Lys Ser Ile His  Ser Ala Ser Thr Pro  Ser Ser Arg 
    1100                 1105                 1110             


Pro Lys  Glu Trp Arg Pro Glu  Lys Ile Ser Asp Leu  Gln Thr Gln 
    1115                 1120                 1125             


Ser Gln  Pro Leu Lys Ser Leu  Arg Lys Leu Leu His  Leu Ser Ser 
    1130                 1135                 1140             


Ala Ser  Asn His Pro Ala Ser  Ser Asp Pro Arg Phe  Gln Pro Leu 
    1145                 1150                 1155             


Thr Ala  Gln Gln Thr Lys Asn  Ser Phe Ser Glu Ile  Arg Ile His 
    1160                 1165                 1170             


Pro Leu  Ser Gln Ala Ser Gly  Gly Ser Ser Asn Ile  Arg Gln Glu 
    1175                 1180                 1185             


Pro Ala  Pro Lys Gly Arg Pro  Ala Leu Gln Leu Pro  Asp Gly Gly 
    1190                 1195                 1200             


Cys Asp  Gly Arg Arg Gln Arg  His His Ser Gly Pro  Gln Asp Arg 
    1205                 1210                 1215             


Arg Phe  Met Leu Arg Thr Thr  Glu Gln Gln Gly Glu  Tyr Phe Cys 
    1220                 1225                 1230             


Cys Gly  Asp Pro Lys Lys Pro  His Thr Pro Cys Val  Pro Asn Arg 
    1235                 1240                 1245             


Ala Leu  His Arg Pro Ile Ser  Ser Pro Ala Pro Tyr  Pro Val Leu 
    1250                 1255                 1260             


Gln Val  Arg Gly Thr Ser Met  Cys Pro Thr Leu Gln  Val Arg Gly 
    1265                 1270                 1275             


Thr Asp  Ala Phe Ser Cys Pro  Thr Gln Gln Ser Gly  Phe Ser Phe 
    1280                 1285                 1290             


Phe Val  Arg His Val Met Arg  Glu Ala Leu Ile His  Arg Ala Gln 
    1295                 1300                 1305             


Val Asn  Gln Ala Ala Leu Leu  Thr Tyr His Glu Asn  Ala Ala Leu 
    1310                 1315                 1320             


Thr Gly  Lys Ser Ala Arg Gly  Gly Pro Glu Gln Lys  Leu Ile Ser 
    1325                 1330                 1335             


Glu Glu  Asp Leu Asn Ser Ala  Val Asp His His His  His His His 
    1340                 1345                 1350             


<210>  11
<211>  3852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKL5 107 isoform fusion protein polynucleotide

<400>  11
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacgcggccc agccggccag gcgcgcgcgc cgtacgaagc ttgcggccta cgccagaaag      120

gccgccaggc aggccagggc accggtcgcc accatggtga gcaagggcga ggagctgttc      180

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc      240

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc      300

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg      360

cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg      420

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc      480

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc      540

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac      600

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc      660

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc      720

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc      780

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg      840

atcactctcg gcatggacga gctgtacaag tccggactca gatctcgagc gaagattcct      900

aacattggta atgtgatgaa taaatttgag atccttgggg ttgtaggtga aggagcctat      960

ggagttgtac ttaaatgcag acacaaggaa acacatgaaa ttgtggcgat caagaaattc     1020

aaggacagtg aagaaaatga agaagtcaaa gaaacgactt tacgagagct taaaatgctt     1080

cggactctca agcaggaaaa cattgtggag ttgaaggaag catttcgtcg gaggggaaag     1140

ttgtacttgg tgtttgagta tgttgaaaaa aatatgctcg aattgctgga agaaatgcca     1200

aatggagttc cacctgagaa agtaaaaagc tacatctatc agctaatcaa ggctattcac     1260

tggtgccata agaatgatat tgtccatcga gatataaaac cagaaaatct cttaatcagc     1320

cacaatgatg tcctaaaact gtgtgacttt ggttttgctc gtaatctgtc agaaggcaat     1380

aatgctaatt acacagagta cgttgccacc agatggtatc ggtccccaga actcttactt     1440

ggcgctccct atggaaagtc cgtggacatg tggtcggtgg gctgtattct tggggagctt     1500

agcgatggac agcctttatt tcctggagaa agtgaaattg accaactttt tactattcag     1560

aaggtgctag gaccacttcc atctgagcag atgaagcttt tctacagtaa tcctcgcttc     1620

catgggctcc ggtttccagc tgttaaccat cctcagtcct tggaaagaag ataccttgga     1680

attttgaata gtgttctact tgacctaatg aagaatttac tgaagttgga cccagctgac     1740

agatacttga cagaacagtg tttgaatcac cctacatttc aaacccagag acttctggat     1800

cgttctcctt caaggtcagc aaaaagaaaa ccttaccatg tggaaagcag cacattgtct     1860

aatagaaacc aagccggcaa aagtactgct ttgcagtctc accacagatc taacagcaag     1920

gacatccaga acctgagtgt aggcctgccc cgggctgacg aaggtctccc tgccaatgaa     1980

agcttcctaa atggaaacct tgctggagct agtcttagtc cactgcacac caaaacctac     2040

caagcaagca gccagcctgg gtctaccagc aaagatctca ccaacaacaa cataccacac     2100

cttcttagcc caaaagaagc caagtcaaaa acagagtttg attttaatat tgacccaaag     2160

ccttcagaag gcccagggac aaagtacctc aagtcaaaca gcagatctca gcagaaccgc     2220

cactcattca tggaaagctc tcaaagcaaa gctgggacac tgcagcccaa tgaaaagcag     2280

agtcggcata gctatattga cacaattccc cagtcctcta ggagtccctc ctacaggacc     2340

aaggccaaaa gccatggggc actgagtgac tccaagtctg tgagcaacct ttctgaagcc     2400

agggcccaaa ttgcggagcc cagtaccagt aggtacttcc catctagctg cttagacttg     2460

aattctccca ccagcccaac ccccaccaga cacagtgaca cgagaacttt gctcagccct     2520

tctggaagaa ataaccgaaa tgagggaacg ctggactcac gtcgaaccac aaccagacat     2580

tctaagacga tggaggaatt gaagctgccg gagcacatgg acagtagcca ttcccattca     2640

ctgtctgcac ctcacgaatc tttttcttat ggactgggct acaccagccc cttttcttcc     2700

cagcaacgtc ctcataggca ttctatgtat gtgacccgtg acaaagtgag agccaagggc     2760

ttggatggaa gcttgagcat agggcaaggg atggcagcta gagccaacag cctgcaactc     2820

ttgtcacccc agcctggaga acagctccct ccagagatga ctgtggcaag atcttcggtc     2880

aaagagacct ccagagaagg cacctcttcc ttccatacac gccagaagtc tgagggtgga     2940

gtgtatcatg acccacactc tgatgatggc acagccccca aagaaaatag acacctatac     3000

aatgatcctg tgccaaggag agttggtagc ttttacagag tgccatctcc acgtccagac     3060

aattctttcc atgaaaataa tgtgtcaact agagtttctt ctctaccatc agagagcagt     3120

tctggaacca accactcaaa aagacaacca gcattcgatc catggaaaag tcctgaaaat     3180

attagtcatt cagagcaact caaggaaaaa gagaagcaag gatttttcag gtcaatgaaa     3240

aagaaaaaga agaaatctca aacagtaccc aattccgaca gccctgatct tctgacgttg     3300

cagaaatcca ttcattctgc tagcactcca agcagcagac caaaggagtg gcgccccgag     3360

aagatctcag atctgcagac ccaaagccag ccattaaaat cactgcgcaa gttgttacat     3420

ctctcttcgg cctcaaatca cccggcttcc tcagatcccc gcttccagcc cttaacagct     3480

caacaaacca aaaattcctt ctcagaaatt cggattcacc ccctgagcca ggcctctggc     3540

gggagcagca acatccggca ggaacccgca ccgaagggca ggccagccct ccagctgcca     3600

ggtcagatgg atcctggttg gcatgtgtcc tctgtgacca ggagtgccac agagggccct     3660

tcctactctg aacagctggg tgccaaaagt gggccaaatg ggcaccccta taacagaaca     3720

aatcgctcac gaatgccaaa tctgaatgat ttaaaagaga cagccttgtc cgctcgagga     3780

gggcccgaac aaaaactcat ctcagaagag gatctgaata gcgccgtcga ccatcatcat     3840

catcatcatt ga                                                         3852


<210>  12
<211>  1283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL5 107 isoform fusion protein polypeptide

<400>  12

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Ala Ala Tyr Ala Arg Lys Ala Ala Arg Gln Ala Arg Ala Pro 
        35                  40                  45              


Val Ala Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
    50                  55                  60                  


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
65                  70                  75                  80  


Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu 
                85                  90                  95      


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
            100                 105                 110         


Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
        115                 120                 125             


His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
    130                 135                 140                 


Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr 
145                 150                 155                 160 


Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
                165                 170                 175     


Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
            180                 185                 190         


Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys 
        195                 200                 205             


Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu 
    210                 215                 220                 


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
225                 230                 235                 240 


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
                245                 250                 255     


Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
            260                 265                 270         


Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
        275                 280                 285             


Tyr Lys Ser Gly Leu Arg Ser Arg Ala Lys Ile Pro Asn Ile Gly Asn 
    290                 295                 300                 


Val Met Asn Lys Phe Glu Ile Leu Gly Val Val Gly Glu Gly Ala Tyr 
305                 310                 315                 320 


Gly Val Val Leu Lys Cys Arg His Lys Glu Thr His Glu Ile Val Ala 
                325                 330                 335     


Ile Lys Lys Phe Lys Asp Ser Glu Glu Asn Glu Glu Val Lys Glu Thr 
            340                 345                 350         


Thr Leu Arg Glu Leu Lys Met Leu Arg Thr Leu Lys Gln Glu Asn Ile 
        355                 360                 365             


Val Glu Leu Lys Glu Ala Phe Arg Arg Arg Gly Lys Leu Tyr Leu Val 
    370                 375                 380                 


Phe Glu Tyr Val Glu Lys Asn Met Leu Glu Leu Leu Glu Glu Met Pro 
385                 390                 395                 400 


Asn Gly Val Pro Pro Glu Lys Val Lys Ser Tyr Ile Tyr Gln Leu Ile 
                405                 410                 415     


Lys Ala Ile His Trp Cys His Lys Asn Asp Ile Val His Arg Asp Ile 
            420                 425                 430         


Lys Pro Glu Asn Leu Leu Ile Ser His Asn Asp Val Leu Lys Leu Cys 
        435                 440                 445             


Asp Phe Gly Phe Ala Arg Asn Leu Ser Glu Gly Asn Asn Ala Asn Tyr 
    450                 455                 460                 


Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu Leu Leu 
465                 470                 475                 480 


Gly Ala Pro Tyr Gly Lys Ser Val Asp Met Trp Ser Val Gly Cys Ile 
                485                 490                 495     


Leu Gly Glu Leu Ser Asp Gly Gln Pro Leu Phe Pro Gly Glu Ser Glu 
            500                 505                 510         


Ile Asp Gln Leu Phe Thr Ile Gln Lys Val Leu Gly Pro Leu Pro Ser 
        515                 520                 525             


Glu Gln Met Lys Leu Phe Tyr Ser Asn Pro Arg Phe His Gly Leu Arg 
    530                 535                 540                 


Phe Pro Ala Val Asn His Pro Gln Ser Leu Glu Arg Arg Tyr Leu Gly 
545                 550                 555                 560 


Ile Leu Asn Ser Val Leu Leu Asp Leu Met Lys Asn Leu Leu Lys Leu 
                565                 570                 575     


Asp Pro Ala Asp Arg Tyr Leu Thr Glu Gln Cys Leu Asn His Pro Thr 
            580                 585                 590         


Phe Gln Thr Gln Arg Leu Leu Asp Arg Ser Pro Ser Arg Ser Ala Lys 
        595                 600                 605             


Arg Lys Pro Tyr His Val Glu Ser Ser Thr Leu Ser Asn Arg Asn Gln 
    610                 615                 620                 


Ala Gly Lys Ser Thr Ala Leu Gln Ser His His Arg Ser Asn Ser Lys 
625                 630                 635                 640 


Asp Ile Gln Asn Leu Ser Val Gly Leu Pro Arg Ala Asp Glu Gly Leu 
                645                 650                 655     


Pro Ala Asn Glu Ser Phe Leu Asn Gly Asn Leu Ala Gly Ala Ser Leu 
            660                 665                 670         


Ser Pro Leu His Thr Lys Thr Tyr Gln Ala Ser Ser Gln Pro Gly Ser 
        675                 680                 685             


Thr Ser Lys Asp Leu Thr Asn Asn Asn Ile Pro His Leu Leu Ser Pro 
    690                 695                 700                 


Lys Glu Ala Lys Ser Lys Thr Glu Phe Asp Phe Asn Ile Asp Pro Lys 
705                 710                 715                 720 


Pro Ser Glu Gly Pro Gly Thr Lys Tyr Leu Lys Ser Asn Ser Arg Ser 
                725                 730                 735     


Gln Gln Asn Arg His Ser Phe Met Glu Ser Ser Gln Ser Lys Ala Gly 
            740                 745                 750         


Thr Leu Gln Pro Asn Glu Lys Gln Ser Arg His Ser Tyr Ile Asp Thr 
        755                 760                 765             


Ile Pro Gln Ser Ser Arg Ser Pro Ser Tyr Arg Thr Lys Ala Lys Ser 
    770                 775                 780                 


His Gly Ala Leu Ser Asp Ser Lys Ser Val Ser Asn Leu Ser Glu Ala 
785                 790                 795                 800 


Arg Ala Gln Ile Ala Glu Pro Ser Thr Ser Arg Tyr Phe Pro Ser Ser 
                805                 810                 815     


Cys Leu Asp Leu Asn Ser Pro Thr Ser Pro Thr Pro Thr Arg His Ser 
            820                 825                 830         


Asp Thr Arg Thr Leu Leu Ser Pro Ser Gly Arg Asn Asn Arg Asn Glu 
        835                 840                 845             


Gly Thr Leu Asp Ser Arg Arg Thr Thr Thr Arg His Ser Lys Thr Met 
    850                 855                 860                 


Glu Glu Leu Lys Leu Pro Glu His Met Asp Ser Ser His Ser His Ser 
865                 870                 875                 880 


Leu Ser Ala Pro His Glu Ser Phe Ser Tyr Gly Leu Gly Tyr Thr Ser 
                885                 890                 895     


Pro Phe Ser Ser Gln Gln Arg Pro His Arg His Ser Met Tyr Val Thr 
            900                 905                 910         


Arg Asp Lys Val Arg Ala Lys Gly Leu Asp Gly Ser Leu Ser Ile Gly 
        915                 920                 925             


Gln Gly Met Ala Ala Arg Ala Asn Ser Leu Gln Leu Leu Ser Pro Gln 
    930                 935                 940                 


Pro Gly Glu Gln Leu Pro Pro Glu Met Thr Val Ala Arg Ser Ser Val 
945                 950                 955                 960 


Lys Glu Thr Ser Arg Glu Gly Thr Ser Ser Phe His Thr Arg Gln Lys 
                965                 970                 975     


Ser Glu Gly Gly Val Tyr His Asp Pro His Ser Asp Asp Gly Thr Ala 
            980                 985                 990         


Pro Lys Glu Asn Arg His Leu Tyr  Asn Asp Pro Val Pro  Arg Arg Val 
        995                 1000                 1005             


Gly Ser  Phe Tyr Arg Val Pro  Ser Pro Arg Pro Asp  Asn Ser Phe 
    1010                 1015                 1020             


His Glu  Asn Asn Val Ser Thr  Arg Val Ser Ser Leu  Pro Ser Glu 
    1025                 1030                 1035             


Ser Ser  Ser Gly Thr Asn His  Ser Lys Arg Gln Pro  Ala Phe Asp 
    1040                 1045                 1050             


Pro Trp  Lys Ser Pro Glu Asn  Ile Ser His Ser Glu  Gln Leu Lys 
    1055                 1060                 1065             


Glu Lys  Glu Lys Gln Gly Phe  Phe Arg Ser Met Lys  Lys Lys Lys 
    1070                 1075                 1080             


Lys Lys  Ser Gln Thr Val Pro  Asn Ser Asp Ser Pro  Asp Leu Leu 
    1085                 1090                 1095             


Thr Leu  Gln Lys Ser Ile His  Ser Ala Ser Thr Pro  Ser Ser Arg 
    1100                 1105                 1110             


Pro Lys  Glu Trp Arg Pro Glu  Lys Ile Ser Asp Leu  Gln Thr Gln 
    1115                 1120                 1125             


Ser Gln  Pro Leu Lys Ser Leu  Arg Lys Leu Leu His  Leu Ser Ser 
    1130                 1135                 1140             


Ala Ser  Asn His Pro Ala Ser  Ser Asp Pro Arg Phe  Gln Pro Leu 
    1145                 1150                 1155             


Thr Ala  Gln Gln Thr Lys Asn  Ser Phe Ser Glu Ile  Arg Ile His 
    1160                 1165                 1170             


Pro Leu  Ser Gln Ala Ser Gly  Gly Ser Ser Asn Ile  Arg Gln Glu 
    1175                 1180                 1185             


Pro Ala  Pro Lys Gly Arg Pro  Ala Leu Gln Leu Pro  Gly Gln Met 
    1190                 1195                 1200             


Asp Pro  Gly Trp His Val Ser  Ser Val Thr Arg Ser  Ala Thr Glu 
    1205                 1210                 1215             


Gly Pro  Ser Tyr Ser Glu Gln  Leu Gly Ala Lys Ser  Gly Pro Asn 
    1220                 1225                 1230             


Gly His  Pro Tyr Asn Arg Thr  Asn Arg Ser Arg Met  Pro Asn Leu 
    1235                 1240                 1245             


Asn Asp  Leu Lys Glu Thr Ala  Leu Ser Ala Arg Gly  Gly Pro Glu 
    1250                 1255                 1260             


Gln Lys  Leu Ile Ser Glu Glu  Asp Leu Asn Ser Ala  Val Asp His 
    1265                 1270                 1275             


His His  His His His 
    1280             


<210>  13
<211>  3120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKL5 107 isoform fusion protein polynucleotide


<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  methionine initiator codon

<400>  13
ctagccacca tggagacaga cacactcctg ctatgggtac tgctgctctg ggttccaggt       60

tccactggtg acgcggccca gccggccagg cgcgcgcgcc gtacgaagct tgcggcctac      120

gccagaaagg ccgccaggca ggccagggca ccggtgaaga ttcctaacat tggtaatgtg      180

atgaataaat ttgagatcct tggggttgta ggtgaaggag cctatggagt tgtacttaaa      240

tgcagacaca aggaaacaca tgaaattgtg gcgatcaaga aattcaagga cagtgaagaa      300

aatgaagaag tcaaagaaac gactttacga gagcttaaaa tgcttcggac tctcaagcag      360

gaaaacattg tggagttgaa ggaagcattt cgtcggaggg gaaagttgta cttggtgttt      420

gagtatgttg aaaaaaatat gctcgaattg ctggaagaaa tgccaaatgg agttccacct      480

gagaaagtaa aaagctacat ctatcagcta atcaaggcta ttcactggtg ccataagaat      540

gatattgtcc atcgagatat aaaaccagaa aatctcttaa tcagccacaa tgatgtccta      600

aaactgtgtg actttggttt tgctcgtaat ctgtcagaag gcaataatgc taattacaca      660

gagtacgttg ccaccagatg gtatcggtcc ccagaactct tacttggcgc tccctatgga      720

aagtccgtgg acatgtggtc ggtgggctgt attcttgggg agcttagcga tggacagcct      780

ttatttcctg gagaaagtga aattgaccaa ctttttacta ttcagaaggt gctaggacca      840

cttccatctg agcagatgaa gcttttctac agtaatcctc gcttccatgg gctccggttt      900

ccagctgtta accatcctca gtccttggaa agaagatacc ttggaatttt gaatagtgtt      960

ctacttgacc taatgaagaa tttactgaag ttggacccag ctgacagata cttgacagaa     1020

cagtgtttga atcaccctac atttcaaacc cagagacttc tggatcgttc tccttcaagg     1080

tcagcaaaaa gaaaacctta ccatgtggaa agcagcacat tgtctaatag aaaccaagcc     1140

ggcaaaagta ctgctttgca gtctcaccac agatctaaca gcaaggacat ccagaacctg     1200

agtgtaggcc tgccccgggc tgacgaaggt ctccctgcca atgaaagctt cctaaatgga     1260

aaccttgctg gagctagtct tagtccactg cacaccaaaa cctaccaagc aagcagccag     1320

cctgggtcta ccagcaaaga tctcaccaac aacaacatac cacaccttct tagcccaaaa     1380

gaagccaagt caaaaacaga gtttgatttt aatattgacc caaagccttc agaaggccca     1440

gggacaaagt acctcaagtc aaacagcaga tctcagcaga accgccactc attcatggaa     1500

agctctcaaa gcaaagctgg gacactgcag cccaatgaaa agcagagtcg gcatagctat     1560

attgacacaa ttccccagtc ctctaggagt ccctcctaca ggaccaaggc caaaagccat     1620

ggggcactga gtgactccaa gtctgtgagc aacctttctg aagccagggc ccaaattgcg     1680

gagcccagta ccagtaggta cttcccatct agctgcttag acttgaattc tcccaccagc     1740

ccaaccccca ccagacacag tgacacgaga actttgctca gcccttctgg aagaaataac     1800

cgaaatgagg gaacgctgga ctcacgtcga accacaacca gacattctaa gacgatggag     1860

gaattgaagc tgccggagca catggacagt agccattccc attcactgtc tgcacctcac     1920

gaatcttttt cttatggact gggctacacc agcccctttt cttcccagca acgtcctcat     1980

aggcattcta tgtatgtgac ccgtgacaaa gtgagagcca agggcttgga tggaagcttg     2040

agcatagggc aagggatggc agctagagcc aacagcctgc aactcttgtc accccagcct     2100

ggagaacagc tccctccaga gatgactgtg gcaagatctt cggtcaaaga gacctccaga     2160

gaaggcacct cttccttcca tacacgccag aagtctgagg gtggagtgta tcatgaccca     2220

cactctgatg atggcacagc ccccaaagaa aatagacacc tatacaatga tcctgtgcca     2280

aggagagttg gtagctttta cagagtgcca tctccacgtc cagacaattc tttccatgaa     2340

aataatgtgt caactagagt ttcttctcta ccatcagaga gcagttctgg aaccaaccac     2400

tcaaaaagac aaccagcatt cgatccatgg aaaagtcctg aaaatattag tcattcagag     2460

caactcaagg aaaaagagaa gcaaggattt ttcaggtcaa tgaaaaagaa aaagaagaaa     2520

tctcaaacag tacccaattc cgacagccct gatcttctga cgttgcagaa atccattcat     2580

tctgctagca ctccaagcag cagaccaaag gagtggcgcc ccgagaagat ctcagatctg     2640

cagacccaaa gccagccatt aaaatcactg cgcaagttgt tacatctctc ttcggcctca     2700

aatcacccgg cttcctcaga tccccgcttc cagcccttaa cagctcaaca aaccaaaaat     2760

tccttctcag aaattcggat tcaccccctg agccaggcct ctggcgggag cagcaacatc     2820

cggcaggaac ccgcaccgaa gggcaggcca gccctccagc tgccaggtca gatggatcct     2880

ggttggcatg tgtcctctgt gaccaggagt gccacagagg gcccttccta ctctgaacag     2940

ctgggtgcca aaagtgggcc aaatgggcac ccctataaca gaacaaatcg ctcacgaatg     3000

ccaaatctga atgatttaaa agagacagcc ttgtctagag gatcccgggc tgactacaaa     3060

gaccatgacg gtgattataa agatcatgac atcgactaca aggatgacga tgacaagtag     3120


<210>  14
<211>  1036
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL5 107 isoform fusion protein polypeptide

<400>  14

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Ala Ala Tyr Ala Arg Lys Ala Ala Arg Gln Ala Arg Ala Pro 
        35                  40                  45              


Val Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
    50                  55                  60                  


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
65                  70                  75                  80  


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
                85                  90                  95      


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
            100                 105                 110         


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
        115                 120                 125             


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
    130                 135                 140                 


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
145                 150                 155                 160 


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
                165                 170                 175     


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
            180                 185                 190         


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
        195                 200                 205             


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
    210                 215                 220                 


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
225                 230                 235                 240 


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
                245                 250                 255     


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
            260                 265                 270         


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
        275                 280                 285             


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
    290                 295                 300                 


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
305                 310                 315                 320 


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
                325                 330                 335     


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
            340                 345                 350         


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
        355                 360                 365             


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
    370                 375                 380                 


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
385                 390                 395                 400 


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
                405                 410                 415     


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
            420                 425                 430         


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
        435                 440                 445             


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
    450                 455                 460                 


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
465                 470                 475                 480 


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
                485                 490                 495     


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
            500                 505                 510         


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
        515                 520                 525             


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
    530                 535                 540                 


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
545                 550                 555                 560 


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
                565                 570                 575     


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
            580                 585                 590         


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
        595                 600                 605             


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
    610                 615                 620                 


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
625                 630                 635                 640 


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
                645                 650                 655     


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
            660                 665                 670         


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
        675                 680                 685             


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
    690                 695                 700                 


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
705                 710                 715                 720 


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
                725                 730                 735     


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
            740                 745                 750         


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
        755                 760                 765             


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
    770                 775                 780                 


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
785                 790                 795                 800 


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
                805                 810                 815     


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
            820                 825                 830         


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
        835                 840                 845             


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
    850                 855                 860                 


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
865                 870                 875                 880 


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
                885                 890                 895     


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
            900                 905                 910         


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
        915                 920                 925             


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
    930                 935                 940                 


Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His 
945                 950                 955                 960 


Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu 
                965                 970                 975     


Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr 
            980                 985                 990         


Asn Arg Ser Arg Met Pro Asn Leu  Asn Asp Leu Lys Glu  Thr Ala Leu 
        995                 1000                 1005             


Ser Arg  Gly Ser Arg Ala Asp  Tyr Lys Asp His Asp  Gly Asp Tyr 
    1010                 1015                 1020             


Lys Asp  His Asp Ile Asp Tyr  Lys Asp Asp Asp Asp  Lys 
    1025                 1030                 1035     


<210>  15
<211>  2877
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDKL5 107 isoform polynucleotide

<400>  15
aagattccta acattggtaa tgtgatgaat aaatttgaga tccttggggt tgtaggtgaa       60

ggagcctatg gagttgtact taaatgcaga cacaaggaaa cacatgaaat tgtggcgatc      120

aagaaattca aggacagtga agaaaatgaa gaagtcaaag aaacgacttt acgagagctt      180

aaaatgcttc ggactctcaa gcaggaaaac attgtggagt tgaaggaagc atttcgtcgg      240

aggggaaagt tgtacttggt gtttgagtat gttgaaaaaa atatgctcga attgctggaa      300

gaaatgccaa atggagttcc acctgagaaa gtaaaaagct acatctatca gctaatcaag      360

gctattcact ggtgccataa gaatgatatt gtccatcgag atataaaacc agaaaatctc      420

ttaatcagcc acaatgatgt cctaaaactg tgtgactttg gttttgctcg taatctgtca      480

gaaggcaata atgctaatta cacagagtac gttgccacca gatggtatcg gtccccagaa      540

ctcttacttg gcgctcccta tggaaagtcc gtggacatgt ggtcggtggg ctgtattctt      600

ggggagctta gcgatggaca gcctttattt cctggagaaa gtgaaattga ccaacttttt      660

actattcaga aggtgctagg accacttcca tctgagcaga tgaagctttt ctacagtaat      720

cctcgcttcc atgggctccg gtttccagct gttaaccatc ctcagtcctt ggaaagaaga      780

taccttggaa ttttgaatag tgttctactt gacctaatga agaatttact gaagttggac      840

ccagctgaca gatacttgac agaacagtgt ttgaatcacc ctacatttca aacccagaga      900

cttctggatc gttctccttc aaggtcagca aaaagaaaac cttaccatgt ggaaagcagc      960

acattgtcta atagaaacca agccggcaaa agtactgctt tgcagtctca ccacagatct     1020

aacagcaagg acatccagaa cctgagtgta ggcctgcccc gggctgacga aggtctccct     1080

gccaatgaaa gcttcctaaa tggaaacctt gctggagcta gtcttagtcc actgcacacc     1140

aaaacctacc aagcaagcag ccagcctggg tctaccagca aagatctcac caacaacaac     1200

ataccacacc ttcttagccc aaaagaagcc aagtcaaaaa cagagtttga ttttaatatt     1260

gacccaaagc cttcagaagg cccagggaca aagtacctca agtcaaacag cagatctcag     1320

cagaaccgcc actcattcat ggaaagctct caaagcaaag ctgggacact gcagcccaat     1380

gaaaagcaga gtcggcatag ctatattgac acaattcccc agtcctctag gagtccctcc     1440

tacaggacca aggccaaaag ccatggggca ctgagtgact ccaagtctgt gagcaacctt     1500

tctgaagcca gggcccaaat tgcggagccc agtaccagta ggtacttccc atctagctgc     1560

ttagacttga attctcccac cagcccaacc cccaccagac acagtgacac gagaactttg     1620

ctcagccctt ctggaagaaa taaccgaaat gagggaacgc tggactcacg tcgaaccaca     1680

accagacatt ctaagacgat ggaggaattg aagctgccgg agcacatgga cagtagccat     1740

tcccattcac tgtctgcacc tcacgaatct ttttcttatg gactgggcta caccagcccc     1800

ttttcttccc agcaacgtcc tcataggcat tctatgtatg tgacccgtga caaagtgaga     1860

gccaagggct tggatggaag cttgagcata gggcaaggga tggcagctag agccaacagc     1920

ctgcaactct tgtcacccca gcctggagaa cagctccctc cagagatgac tgtggcaaga     1980

tcttcggtca aagagacctc cagagaaggc acctcttcct tccatacacg ccagaagtct     2040

gagggtggag tgtatcatga cccacactct gatgatggca cagcccccaa agaaaataga     2100

cacctataca atgatcctgt gccaaggaga gttggtagct tttacagagt gccatctcca     2160

cgtccagaca attctttcca tgaaaataat gtgtcaacta gagtttcttc tctaccatca     2220

gagagcagtt ctggaaccaa ccactcaaaa agacaaccag cattcgatcc atggaaaagt     2280

cctgaaaata ttagtcattc agagcaactc aaggaaaaag agaagcaagg atttttcagg     2340

tcaatgaaaa agaaaaagaa gaaatctcaa acagtaccca attccgacag ccctgatctt     2400

ctgacgttgc agaaatccat tcattctgct agcactccaa gcagcagacc aaaggagtgg     2460

cgccccgaga agatctcaga tctgcagacc caaagccagc cattaaaatc actgcgcaag     2520

ttgttacatc tctcttcggc ctcaaatcac ccggcttcct cagatccccg cttccagccc     2580

ttaacagctc aacaaaccaa aaattccttc tcagaaattc ggattcaccc cctgagccag     2640

gcctctggcg ggagcagcaa catccggcag gaacccgcac cgaagggcag gccagccctc     2700

cagctgccag gtcagatgga tcctggttgg catgtgtcct ctgtgaccag gagtgccaca     2760

gagggccctt cctactctga acagctgggt gccaaaagtg ggccaaatgg gcacccctat     2820

aacagaacaa atcgctcacg aatgccaaat ctgaatgatt taaaagagac agccttg        2877


<210>  16
<211>  959
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDKL5 107 isoform polypeptide

<400>  16

Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu Gly 
1               5                   10                  15      


Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His Lys 
            20                  25                  30          


Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu Glu 
        35                  40                  45              


Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu Arg 
    50                  55                  60                  


Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg Arg 
65                  70                  75                  80  


Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met Leu 
                85                  90                  95      


Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val Lys 
            100                 105                 110         


Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys Asn 
        115                 120                 125             


Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser His 
    130                 135                 140                 


Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu Ser 
145                 150                 155                 160 


Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp Tyr 
                165                 170                 175     


Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val Asp 
            180                 185                 190         


Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln Pro 
        195                 200                 205             


Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln Lys 
    210                 215                 220                 


Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser Asn 
225                 230                 235                 240 


Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln Ser 
                245                 250                 255     


Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp Leu 
            260                 265                 270         


Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr Glu 
        275                 280                 285             


Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp Arg 
    290                 295                 300                 


Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser Ser 
305                 310                 315                 320 


Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser 
                325                 330                 335     


His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly Leu 
            340                 345                 350         


Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly 
        355                 360                 365             


Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr Gln 
    370                 375                 380                 


Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn 
385                 390                 395                 400 


Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe 
                405                 410                 415     


Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr 
            420                 425                 430         


Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met Glu 
        435                 440                 445             


Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser 
    450                 455                 460                 


Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser 
465                 470                 475                 480 


Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys Ser 
                485                 490                 495     


Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr 
            500                 505                 510         


Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser 
        515                 520                 525             


Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser 
    530                 535                 540                 


Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr 
545                 550                 555                 560 


Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His Met 
                565                 570                 575     


Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe Ser 
            580                 585                 590         


Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro His 
        595                 600                 605             


Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly Leu 
    610                 615                 620                 


Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn Ser 
625                 630                 635                 640 


Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu Met 
                645                 650                 655     


Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr Ser 
            660                 665                 670         


Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp Pro 
        675                 680                 685             


His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr Asn 
    690                 695                 700                 


Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser Pro 
705                 710                 715                 720 


Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val Ser 
                725                 730                 735     


Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg Gln 
            740                 745                 750         


Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser Glu 
        755                 760                 765             


Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys Lys 
    770                 775                 780                 


Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp Leu 
785                 790                 795                 800 


Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser Arg 
                805                 810                 815     


Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln Ser 
            820                 825                 830         


Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala Ser 
        835                 840                 845             


Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala Gln 
    850                 855                 860                 


Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser Gln 
865                 870                 875                 880 


Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys Gly 
                885                 890                 895     


Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His Val 
            900                 905                 910         


Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu Gln 
        915                 920                 925             


Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr Asn 
    930                 935                 940                 


Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
945                 950                 955                 


