                         SEQUENCE LISTING

<110>  BISSIG , Karl-Dimiter
 
<120>  HUMAN LIVER CHIMERIC NON-HUMAN ANIMAL WITH DEFICIENT P450 
       OXIDOREDUCTASE AND METHODS OF USING SAME

<130>  KARL-001/001WO

<150>  US 62/355,102
<151>  2016-06-27

<150>  US 62/509,942
<151>  2017-05-23

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
ggcctcagag aggacatagt gccc                                              24


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  2
gccctctggt gtcaggtccc                                                   20


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
cctcacgcag cttaatgtgg cc                                                22


<210>  4
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
ggaagttaag gacgtgatta cagggagc                                          28


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
ctgggttgca tactggtggg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
aaacagggtc tttgctgctg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
acaaaggtgt ggcaagggtt                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
ccaccggaag ctacgacaaa                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
gggggaattg gaggcattct                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
cttcttcccg tgctaccctc                                                   20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
cctcccacct cttcgttatc c                                                 21


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
agtctgaggg gcttttgcta                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
agtctgaggg gcttttgcta                                                   20


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
ggccccacct gtcaaagaga gcagc                                             25


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
caaacttgac acccgtgagg tcc                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
tctatggctc ccagacggga acc                                               23


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
ccaatcatag aagtcctgcg cg                                                22


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
ccaatcatag aagtcctgcg cg                                                22


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
accttggccg catctatgtc gg                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
agaacatcat ccctgcatcc a                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
cagatccacg acggacacat t                                                 21


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
cagaacatca tccctgcctc tac                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  23
ttgaagtcag aggagaccac ctg                                               23


<210>  24
<211>  2509
<212>  DNA
<213>  Homo sapiens

<400>  24
gaaggcggtg gtagcgcctc agtggtgtgg gcctgagccc tgcccaggtg cccgcagaga       60

gcagccgggc tgccagcgtt tcatgatcaa catgggagac tcccacgtgg acaccagctc      120

caccgtgtcc gaggcggtgg ccgaagaagt atctcttttc agcatgacgg acatgattct      180

gttttcgctc atcgtgggtc tcctaaccta ctggttcctc ttcagaaaga aaaaagaaga      240

agtccccgag ttcaccaaaa ttcagacatt gacctcctct gtcagagaga gcagctttgt      300

ggaaaagatg aagaaaacgg ggaggaacat catcgtgttc tacggctccc agacggggac      360

tgcagaggag tttgccaacc gcctgtccaa ggacgcccac cgctacggga tgcgaggcat      420

gtcagcggac cctgaggagt atgacctggc cgacctgagc agcctgccag agatcgacaa      480

cgccctggtg gttttctgca tggccaccta cggtgaggga gaccccaccg acaatgccca      540

ggacttctac gactggctgc aggagacaga cgtggatctc tctggggtca agttcgcggt      600

gtttggtctt gggaacaaga cctacgagca cttcaatgcc atgggcaagt acgtggacaa      660

gcggctggag cagctcggcg cccagcgcat ctttgagctg gggttgggcg acgacgatgg      720

gaacttggag gaggacttca tcacctggcg agagcagttc tggccggccg tgtgtgaaca      780

ctttggggtg gaagccactg gcgaggagtc cagcattcgc cagtacgagc ttgtggtcca      840

caccgacata gatgcggcca aggtgtacat gggggagatg ggccggctga agagctacga      900

gaaccagaag cccccctttg atgccaagaa tccgttcctg gctgcagtca ccaccaaccg      960

gaagctgaac cagggaaccg agcgccacct catgcacctg gaattggaca tctcggactc     1020

caaaatcagg tatgaatctg gggaccacgt ggctgtgtac ccagccaacg actctgctct     1080

cgtcaaccag ctgggcaaaa tcctgggtgc cgacctggac gtcgtcatgt ccctgaacaa     1140

cctggatgag gagtccaaca agaagcaccc attcccgtgc cctacgtcct accgcacggc     1200

cctcacctac tacctggaca tcaccaaccc gccgcgtacc aacgtgctgt acgagctggc     1260

gcagtacgcc tcggagccct cggagcagga gctgctgcgc aagatggcct cctcctccgg     1320

cgagggcaag gagctgtacc tgagctgggt ggtggaggcc cggaggcaca tcctggccat     1380

cctgcaggac tgcccgtccc tgcggccccc catcgaccac ctgtgtgagc tgctgccgcg     1440

cctgcaggcc cgctactact ccatcgcctc atcctccaag gtccacccca actctgtgca     1500

catctgtgcg gtggttgtgg agtacgagac caaggctggc cgcatcaaca agggcgtggc     1560

caccaactgg ctgcgggcca aggagcctgc cggggagaac ggcggccgtg cgctggtgcc     1620

catgttcgtg cgcaagtccc agttccgcct gcccttcaag gccaccacgc ctgtcatcat     1680

ggtgggcccc ggcaccgggg tggcaccctt cataggcttc atccaggagc gggcctggct     1740

gcgacagcag ggcaaggagg tgggggagac gctgctgtac tacggctgcc gccgctcgga     1800

tgaggactac ctgtaccggg aggagctggc gcagttccac agggacggtg cgctcaccca     1860

gctcaacgtg gccttctccc gggagcagtc ccacaaggtc tacgtccagc acctgctaaa     1920

gcaagaccga gagcacctgt ggaagttgat cgaaggcggt gcccacatct acgtctgtgg     1980

ggatgcacgg aacatggcca gggatgtgca gaacaccttc tacgacatcg tggctgagct     2040

cggggccatg gagcacgcgc aggcggtgga ctacatcaag aaactgatga ccaagggccg     2100

ctactccctg gacgtgtgga gctaggggcc tgcctgcccc acccacccca cagactccgg     2160

cctgtaatca gctctcctgg ctccctcccg tagtctcctg ggtgtgtttg gcttggcctt     2220

ggcatgggcg caggcccagt gacaaagact cctctgggcc tggggtgcat cctcctcagc     2280

ccccaggcca ggtgaggtcc accggcccct ggcagcacag cccagggcct gcatgggggc     2340

accgggctcc atgcctctgg aggcctctgg ccctcggtgg ctgcacagaa gggctctttc     2400

tctctgctga gctgggccca gcccctccac gtgatttcca gtgagtgtaa ataattttaa     2460

ataacctctg gcccttggaa taaagttctg ttttctgtaa aaaaaaaaa                 2509


<210>  25
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ile Asn Met Gly Asp Ser His Val Asp Thr Ser Ser Thr Val Ser 
1               5                   10                  15      


Glu Ala Val Ala Glu Glu Val Ser Leu Phe Ser Met Thr Asp Met Ile 
            20                  25                  30          


Leu Phe Ser Leu Ile Val Gly Leu Leu Thr Tyr Trp Phe Leu Phe Arg 
        35                  40                  45              


Lys Lys Lys Glu Glu Val Pro Glu Phe Thr Lys Ile Gln Thr Leu Thr 
    50                  55                  60                  


Ser Ser Val Arg Glu Ser Ser Phe Val Glu Lys Met Lys Lys Thr Gly 
65                  70                  75                  80  


Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Glu 
                85                  90                  95      


Phe Ala Asn Arg Leu Ser Lys Asp Ala His Arg Tyr Gly Met Arg Gly 
            100                 105                 110         


Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu Ala Asp Leu Ser Ser Leu 
        115                 120                 125             


Pro Glu Ile Asp Asn Ala Leu Val Val Phe Cys Met Ala Thr Tyr Gly 
    130                 135                 140                 


Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp Phe Tyr Asp Trp Leu Gln 
145                 150                 155                 160 


Glu Thr Asp Val Asp Leu Ser Gly Val Lys Phe Ala Val Phe Gly Leu 
                165                 170                 175     


Gly Asn Lys Thr Tyr Glu His Phe Asn Ala Met Gly Lys Tyr Val Asp 
            180                 185                 190         


Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg Ile Phe Glu Leu Gly Leu 
        195                 200                 205             


Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp Phe Ile Thr Trp Arg Glu 
    210                 215                 220                 


Gln Phe Trp Pro Ala Val Cys Glu His Phe Gly Val Glu Ala Thr Gly 
225                 230                 235                 240 


Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu Val Val His Thr Asp Ile 
                245                 250                 255     


Asp Ala Ala Lys Val Tyr Met Gly Glu Met Gly Arg Leu Lys Ser Tyr 
            260                 265                 270         


Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys Asn Pro Phe Leu Ala Ala 
        275                 280                 285             


Val Thr Thr Asn Arg Lys Leu Asn Gln Gly Thr Glu Arg His Leu Met 
    290                 295                 300                 


His Leu Glu Leu Asp Ile Ser Asp Ser Lys Ile Arg Tyr Glu Ser Gly 
305                 310                 315                 320 


Asp His Val Ala Val Tyr Pro Ala Asn Asp Ser Ala Leu Val Asn Gln 
                325                 330                 335     


Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp Val Val Met Ser Leu Asn 
            340                 345                 350         


Asn Leu Asp Glu Glu Ser Asn Lys Lys His Pro Phe Pro Cys Pro Thr 
        355                 360                 365             


Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu Asp Ile Thr Asn Pro Pro 
    370                 375                 380                 


Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln Tyr Ala Ser Glu Pro Ser 
385                 390                 395                 400 


Glu Gln Glu Leu Leu Arg Lys Met Ala Ser Ser Ser Gly Glu Gly Lys 
                405                 410                 415     


Glu Leu Tyr Leu Ser Trp Val Val Glu Ala Arg Arg His Ile Leu Ala 
            420                 425                 430         


Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro Pro Ile Asp His Leu Cys 
        435                 440                 445             


Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr Tyr Ser Ile Ala Ser Ser 
    450                 455                 460                 


Ser Lys Val His Pro Asn Ser Val His Ile Cys Ala Val Val Val Glu 
465                 470                 475                 480 


Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys Gly Val Ala Thr Asn Trp 
                485                 490                 495     


Leu Arg Ala Lys Glu Pro Ala Gly Glu Asn Gly Gly Arg Ala Leu Val 
            500                 505                 510         


Pro Met Phe Val Arg Lys Ser Gln Phe Arg Leu Pro Phe Lys Ala Thr 
        515                 520                 525             


Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Ile 
    530                 535                 540                 


Gly Phe Ile Gln Glu Arg Ala Trp Leu Arg Gln Gln Gly Lys Glu Val 
545                 550                 555                 560 


Gly Glu Thr Leu Leu Tyr Tyr Gly Cys Arg Arg Ser Asp Glu Asp Tyr 
                565                 570                 575     


Leu Tyr Arg Glu Glu Leu Ala Gln Phe His Arg Asp Gly Ala Leu Thr 
            580                 585                 590         


Gln Leu Asn Val Ala Phe Ser Arg Glu Gln Ser His Lys Val Tyr Val 
        595                 600                 605             


Gln His Leu Leu Lys Gln Asp Arg Glu His Leu Trp Lys Leu Ile Glu 
    610                 615                 620                 


Gly Gly Ala His Ile Tyr Val Cys Gly Asp Ala Arg Asn Met Ala Arg 
625                 630                 635                 640 


Asp Val Gln Asn Thr Phe Tyr Asp Ile Val Ala Glu Leu Gly Ala Met 
                645                 650                 655     


Glu His Ala Gln Ala Val Asp Tyr Ile Lys Lys Leu Met Thr Lys Gly 
            660                 665                 670         


Arg Tyr Ser Leu Asp Val Trp Ser 
        675                 680 


<210>  26
<211>  2527
<212>  DNA
<213>  Mus musculus

<400>  26
gggccgtggt agcgcctcag tggtgcgggc ttgcgtccgg ccccagtgcc tcagagacct       60

acaggaccgc gcgcggtgtg tgatctggtc ggtaccgagg agcgcaggtt gtgtcaccaa      120

catgggggac tctcacgaag acaccagtgc cacagtgcct gaggcagtgg ctgaagaagt      180

gtctctattc agcacaacgg acattgttct gttttctctc atcgtggggg tcctgaccta      240

ctggttcatc tttaaaaaga agaaagaaga gataccggag ttcagcaaga tccagacaac      300

ggccccacct gtcaaagaga gcagcttcgt ggaaaagatg aagaaaacgg gaaggaacat      360

tattgtattc tatggctccc agacgggaac cgcggaggag tttgccaacc ggctgtccaa      420

ggatgcccac cgctatggga tgcggggcat gtctgcagac cctgaagagt atgacttggc      480

cgacctgagc agcctgcctg agatcgacaa gtccctggta gtcttctgca tggccacata      540

cggagaaggc gaccccaccg acaacgcgca ggacttctat gattggctgc aggagactga      600

cgtggacctc acgggtgtca agtttgctgt gtttggtctc gggaacaaga cctatgagca      660

cttcaacgcc atgggcaagt atgtggacca gcggctggag cagcttggcg cccagcgaat      720

ctttgagttg ggccttggtg atgacgacgg gaacttggaa gaggatttca tcacatggag      780

ggagcagttc tggccagctg tgtgcgagtt cttcggggtg gaagccactg gggaggagtc      840

gagcatccgc cagtacgagc tcgtggtcca cgaagacatg gacacagcca aggtgtacac      900

gggtgagatg ggccgtctga agagctacga gaaccagaaa ccccccttcg atgccaagaa      960

tccattcctg gctgctgtca ccacgaaccg gaagctgaac caaggcactg agaggcatct     1020

aatgcacctg gaattggaca tctcagactc caagatcagg tatgaatctg gagatcacgt     1080

ggctgtgtac ccagccaacg actccaccct ggtcaaccag attggggaga tcctgggggc     1140

tgacctggat gtcatcatgt ctctaaacaa tctcgatgag gagtcgaata agaagcatcc     1200

gttcccctgc cccaccacct accgcacggc cctcacctac tacctggaca tcactaaccc     1260

gccacgaacc aacgtgctct acgagctggc ccagtacgcc tcagagccct cggagcagga     1320

acacctgcac aagatggcgt cctcctccgg cgagggcaag gagctgtacc tgagctgggt     1380

ggtggaggcc cggaggcaca tcctagccat tctccaagac tacccgtccc tgcggccacc     1440

catcgaccac ctgtgcgagc tcctcccgag gctgcaggcc cgctactatt ccattgcctc     1500

gtcgtctaag gtccacccca actccgtgca catctgcgcc gtggctgtgg agtatgaagc     1560

gaagtctgga cgagtgaaca agggggtggc caccagctgg cttcggacca aggaaccagc     1620

aggagagaat ggccgccggg ccctggtccc catgttcgtc cgcaagtccc agttccgctt     1680

gcctttcaag cccaccacac ctgttatcat ggtgggcccc ggcactgggg ttgccccttt     1740

catgggcttc atccaggagc gggcttggct tcgagagcaa ggcaaggagg tcggagagac     1800

gctgctctac tacggctgcc ggcgctcgga tgaggactat ctgtaccgcg aggagctggc     1860

gcgcttccac aaggacggcg ccctcacgca gcttaatgtg gccttttccc gtgagcaggc     1920

ccacaaggtc tatgttcagc acctgctcaa gagggacaaa gagcacctgt ggaagctgat     1980

ccacgaaggt ggtgcccaca tctatgtctg cggggatgct cgaaatatgg ccaaagatgt     2040

gcagaacaca ttctatgaca tcgtggccga gtttgggccc atggagcaca cccaggctgt     2100

ggactatgtt aagaagctca tgaccaaggg ccgctactcg ctggatgtat ggagctagga     2160

gctgccgccc cccacccctc gctccctgta atcacgtcct taacttcctt ctgccgacct     2220

ccacctctgg tggttcctgc cctgcctgga cacagggagg cccagggact gactcctggc     2280

ctgagtgatg ccctcctggg cccttaggca gagcctggtc cattgtacca ggcagcctag     2340

cccagcccag ggcacatggc aagagggact ggacccacct ttgggtgatg ggtgccttag     2400

gtccccagca gctgtacaga aggggctctt ctctccacag agctggggtg cagccccaac     2460

atgtgatttt gaatgagtgt aaataatttt aaataacctg gcccttggaa taaagttgtt     2520

ttctgta                                                               2527


<210>  27
<211>  678
<212>  PRT
<213>  Mus musculus

<400>  27

Met Gly Asp Ser His Glu Asp Thr Ser Ala Thr Val Pro Glu Ala Val 
1               5                   10                  15      


Ala Glu Glu Val Ser Leu Phe Ser Thr Thr Asp Ile Val Leu Phe Ser 
            20                  25                  30          


Leu Ile Val Gly Val Leu Thr Tyr Trp Phe Ile Phe Lys Lys Lys Lys 
        35                  40                  45              


Glu Glu Ile Pro Glu Phe Ser Lys Ile Gln Thr Thr Ala Pro Pro Val 
    50                  55                  60                  


Lys Glu Ser Ser Phe Val Glu Lys Met Lys Lys Thr Gly Arg Asn Ile 
65                  70                  75                  80  


Ile Val Phe Tyr Gly Ser Gln Thr Gly Thr Ala Glu Glu Phe Ala Asn 
                85                  90                  95      


Arg Leu Ser Lys Asp Ala His Arg Tyr Gly Met Arg Gly Met Ser Ala 
            100                 105                 110         


Asp Pro Glu Glu Tyr Asp Leu Ala Asp Leu Ser Ser Leu Pro Glu Ile 
        115                 120                 125             


Asp Lys Ser Leu Val Val Phe Cys Met Ala Thr Tyr Gly Glu Gly Asp 
    130                 135                 140                 


Pro Thr Asp Asn Ala Gln Asp Phe Tyr Asp Trp Leu Gln Glu Thr Asp 
145                 150                 155                 160 


Val Asp Leu Thr Gly Val Lys Phe Ala Val Phe Gly Leu Gly Asn Lys 
                165                 170                 175     


Thr Tyr Glu His Phe Asn Ala Met Gly Lys Tyr Val Asp Gln Arg Leu 
            180                 185                 190         


Glu Gln Leu Gly Ala Gln Arg Ile Phe Glu Leu Gly Leu Gly Asp Asp 
        195                 200                 205             


Asp Gly Asn Leu Glu Glu Asp Phe Ile Thr Trp Arg Glu Gln Phe Trp 
    210                 215                 220                 


Pro Ala Val Cys Glu Phe Phe Gly Val Glu Ala Thr Gly Glu Glu Ser 
225                 230                 235                 240 


Ser Ile Arg Gln Tyr Glu Leu Val Val His Glu Asp Met Asp Thr Ala 
                245                 250                 255     


Lys Val Tyr Thr Gly Glu Met Gly Arg Leu Lys Ser Tyr Glu Asn Gln 
            260                 265                 270         


Lys Pro Pro Phe Asp Ala Lys Asn Pro Phe Leu Ala Ala Val Thr Thr 
        275                 280                 285             


Asn Arg Lys Leu Asn Gln Gly Thr Glu Arg His Leu Met His Leu Glu 
    290                 295                 300                 


Leu Asp Ile Ser Asp Ser Lys Ile Arg Tyr Glu Ser Gly Asp His Val 
305                 310                 315                 320 


Ala Val Tyr Pro Ala Asn Asp Ser Thr Leu Val Asn Gln Ile Gly Glu 
                325                 330                 335     


Ile Leu Gly Ala Asp Leu Asp Val Ile Met Ser Leu Asn Asn Leu Asp 
            340                 345                 350         


Glu Glu Ser Asn Lys Lys His Pro Phe Pro Cys Pro Thr Thr Tyr Arg 
        355                 360                 365             


Thr Ala Leu Thr Tyr Tyr Leu Asp Ile Thr Asn Pro Pro Arg Thr Asn 
    370                 375                 380                 


Val Leu Tyr Glu Leu Ala Gln Tyr Ala Ser Glu Pro Ser Glu Gln Glu 
385                 390                 395                 400 


His Leu His Lys Met Ala Ser Ser Ser Gly Glu Gly Lys Glu Leu Tyr 
                405                 410                 415     


Leu Ser Trp Val Val Glu Ala Arg Arg His Ile Leu Ala Ile Leu Gln 
            420                 425                 430         


Asp Tyr Pro Ser Leu Arg Pro Pro Ile Asp His Leu Cys Glu Leu Leu 
        435                 440                 445             


Pro Arg Leu Gln Ala Arg Tyr Tyr Ser Ile Ala Ser Ser Ser Lys Val 
    450                 455                 460                 


His Pro Asn Ser Val His Ile Cys Ala Val Ala Val Glu Tyr Glu Ala 
465                 470                 475                 480 


Lys Ser Gly Arg Val Asn Lys Gly Val Ala Thr Ser Trp Leu Arg Thr 
                485                 490                 495     


Lys Glu Pro Ala Gly Glu Asn Gly Arg Arg Ala Leu Val Pro Met Phe 
            500                 505                 510         


Val Arg Lys Ser Gln Phe Arg Leu Pro Phe Lys Pro Thr Thr Pro Val 
        515                 520                 525             


Ile Met Val Gly Pro Gly Thr Gly Val Ala Pro Phe Met Gly Phe Ile 
    530                 535                 540                 


Gln Glu Arg Ala Trp Leu Arg Glu Gln Gly Lys Glu Val Gly Glu Thr 
545                 550                 555                 560 


Leu Leu Tyr Tyr Gly Cys Arg Arg Ser Asp Glu Asp Tyr Leu Tyr Arg 
                565                 570                 575     


Glu Glu Leu Ala Arg Phe His Lys Asp Gly Ala Leu Thr Gln Leu Asn 
            580                 585                 590         


Val Ala Phe Ser Arg Glu Gln Ala His Lys Val Tyr Val Gln His Leu 
        595                 600                 605             


Leu Lys Arg Asp Lys Glu His Leu Trp Lys Leu Ile His Glu Gly Gly 
    610                 615                 620                 


Ala His Ile Tyr Val Cys Gly Asp Ala Arg Asn Met Ala Lys Asp Val 
625                 630                 635                 640 


Gln Asn Thr Phe Tyr Asp Ile Val Ala Glu Phe Gly Pro Met Glu His 
                645                 650                 655     


Thr Gln Ala Val Asp Tyr Val Lys Lys Leu Met Thr Lys Gly Arg Tyr 
            660                 665                 670         


Ser Leu Asp Val Trp Ser 
        675             


<210>  28
<211>  1560
<212>  DNA
<213>  Homo sapiens

<400>  28
agaggaaacg tgtgggtggg gaggggtagt gggtgaggga cccaggttcc tgacacagac       60

agactacacc cagggaatga agagcaagcg ccatgttgaa gccatcatta ccattcacat      120

ccctcttatt cctgcagctg cccctgctgg gagtggggct gaacacgaca attctgacgc      180

ccaatgggaa tgaagacacc acagctgatt tcttcctgac cactatgccc actgactccc      240

tcagtgtttc cactctgccc ctcccagagg ttcagtgttt tgtgttcaat gtcgagtaca      300

tgaattgcac ttggaacagc agctctgagc cccagcctac caacctcact ctgcattatt      360

ggtacaagaa ctcggataat gataaagtcc agaagtgcag ccactatcta ttctctgaag      420

aaatcacttc tggctgtcag ttgcaaaaaa aggagatcca cctctaccaa acatttgttg      480

ttcagctcca ggacccacgg gaacccagga gacaggccac acagatgcta aaactgcaga      540

atctggtgat cccctgggct ccagagaacc taacacttca caaactgagt gaatcccagc      600

tagaactgaa ctggaacaac agattcttga accactgttt ggagcacttg gtgcagtacc      660

ggactgactg ggaccacagc tggactgaac aatcagtgga ttatagacat aagttctcct      720

tgcctagtgt ggatgggcag aaacgctaca cgtttcgtgt tcggagccgc tttaacccac      780

tctgtggaag tgctcagcat tggagtgaat ggagccaccc aatccactgg gggagcaata      840

cttcaaaaga gaatcctttc ctgtttgcat tggaagccgt ggttatctct gttggctcca      900

tgggattgat tatcagcctt ctctgtgtgt atttctggct ggaacggacg atgccccgaa      960

ttcccaccct gaagaaccta gaggatcttg ttactgaata ccacgggaac ttttcggcct     1020

ggagtggtgt gtctaaggga ctggctgaga gtctgcagcc agactacagt gaacgactct     1080

gcctcgtcag tgagattccc ccaaaaggag gggcccttgg ggaggggcct ggggcctccc     1140

catgcaacca gcatagcccc tactgggccc ccccatgtta caccctaaag cctgaaacct     1200

gaaccccaat cctctgacag aagaacccca gggtcctgta gccctaagtg gtactaactt     1260

tccttcattc aacccacctg cgtctcatac tcacctcacc ccactgtggc tgatttggaa     1320

ttttgtgccc ccatgtaagc accccttcat ttggcattcc ccacttgaga attacccttt     1380

tgccccgaac atgtttttct tctccctcag tctggccctt ccttttcgca ggattcttcc     1440

tccctccctc tttccctccc ttcctctttc catctaccct ccgattgttc ctgaaccgat     1500

gagaaataaa gtttctgttg ataatcatca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560


<210>  29
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            260                 265                 270         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        275                 280                 285             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            340                 345                 350         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        355                 360                 365             


Thr 
    


<210>  30
<211>  1663
<212>  DNA
<213>  Mus musculus

<400>  30
aggaaatgta tgggtgggga gggcttgtgg gagagtggtt cagggttctg acacagacta       60

cacccagaga aagaagagca agcaccatgt tgaaactatt attgtcacct agatccttct      120

tagtccttca gctgctcctg ctgagggcag ggtggagctc caaggtcctc atgtccagtg      180

cgaatgaaga catcaaagct gatttgatcc tgacttctac agcccctgaa cacctcagtg      240

ctcctactct gccccttcca gaggttcagt gctttgtgtt caacatagag tacatgaatt      300

gcacttggaa tagcagttct gagcctcagg caaccaacct cacgctgcac tataggtaca      360

aggtatctga taataataca ttccaggagt gcagtcacta tttgttctcc aaagagatta      420

cttctggctg tcagatacaa aaagaagata tccagctcta ccagacattt gttgtccagc      480

tccaggaccc ccagaaaccc cagaggcgag ctgtacagaa gctaaaccta cagaatcttg      540

tgatcccacg ggctccagaa aatctaacac tcagcaatct gagtgaatcc cagctagagc      600

tgagatggaa aagcagacat attaaagaac gctgtttaca atacttggtg cagtaccgga      660

gcaacagaga tcgaagctgg acggaactaa tagtgaatca tgaacctaga ttctccctgc      720

ctagtgtgga tgagctgaaa cggtacacat ttcgggttcg gagccgctat aacccaatct      780

gtggaagttc tcaacagtgg agtaaatgga gccagcctgt ccactggggg agtcatactg      840

tagaggagaa tccttccttg tttgcactgg aagctgtgct tatccctgtt ggcaccatgg      900

ggttgattat taccctgatc tttgtgtact gttggttgga acgaatgcct ccaattcccc      960

ccatcaagaa tctagaggat ctggttactg aataccaagg gaacttttcg gcctggagtg     1020

gtgtgtctaa agggctgact gagagtctgc agccagacta cagtgaacgg ttctgccacg     1080

tcagcgagat tccccccaaa ggaggggccc taggagaggg gcctggaggt tctccttgca     1140

gcctgcatag cccttactgg cctcccccat gttattctct gaagccggaa gcctgaacat     1200

caatcctttg atggaacctc aaagtcctat agtcctaagt gacgctaacc tcccctactc     1260

accttggcaa tctggatcca atgctcactg ccttcccttg gggctaagtt tcgatttcct     1320

gtcccatgta actgcttttc tgttccatat gccctacttg agagtgtccc ttgccctctt     1380

tccctgcaca agccctccca tgcccagcct aacacctttc cactttcttt gaagagagtc     1440

ttaccctgta gcccagggtg gctgggagct cactatgtag gccaggttgg cctccaactc     1500

acaggctatc ctcccacctc tgcctcataa gagttggggt tactggcatg caccaccaca     1560

cccagcatgg tccttctctt ttataggatt ctccctccct ttttctacct atgattcaac     1620

tgtttccaaa tcaacaagaa ataaagtttt taaccaatga tca                       1663


<210>  31
<211>  369
<212>  PRT
<213>  Mus musculus

<400>  31

Met Leu Lys Leu Leu Leu Ser Pro Arg Ser Phe Leu Val Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Arg Ala Gly Trp Ser Ser Lys Val Leu Met Ser Ser Ala 
            20                  25                  30          


Asn Glu Asp Ile Lys Ala Asp Leu Ile Leu Thr Ser Thr Ala Pro Glu 
        35                  40                  45              


His Leu Ser Ala Pro Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Ile Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Ala Thr Asn Leu Thr Leu His Tyr Arg Tyr Lys Val Ser Asp Asn 
                85                  90                  95      


Asn Thr Phe Gln Glu Cys Ser His Tyr Leu Phe Ser Lys Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Ile Gln Lys Glu Asp Ile Gln Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Gln Lys Pro Gln Arg Arg Ala Val Gln 
    130                 135                 140                 


Lys Leu Asn Leu Gln Asn Leu Val Ile Pro Arg Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu Ser Asn Leu Ser Glu Ser Gln Leu Glu Leu Arg Trp Lys Ser 
                165                 170                 175     


Arg His Ile Lys Glu Arg Cys Leu Gln Tyr Leu Val Gln Tyr Arg Ser 
            180                 185                 190         


Asn Arg Asp Arg Ser Trp Thr Glu Leu Ile Val Asn His Glu Pro Arg 
        195                 200                 205             


Phe Ser Leu Pro Ser Val Asp Glu Leu Lys Arg Tyr Thr Phe Arg Val 
    210                 215                 220                 


Arg Ser Arg Tyr Asn Pro Ile Cys Gly Ser Ser Gln Gln Trp Ser Lys 
225                 230                 235                 240 


Trp Ser Gln Pro Val His Trp Gly Ser His Thr Val Glu Glu Asn Pro 
                245                 250                 255     


Ser Leu Phe Ala Leu Glu Ala Val Leu Ile Pro Val Gly Thr Met Gly 
            260                 265                 270         


Leu Ile Ile Thr Leu Ile Phe Val Tyr Cys Trp Leu Glu Arg Met Pro 
        275                 280                 285             


Pro Ile Pro Pro Ile Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr Gln 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Thr Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Phe Cys His Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Gly Ser Pro Cys Ser 
            340                 345                 350         


Leu His Ser Pro Tyr Trp Pro Pro Pro Cys Tyr Ser Leu Lys Pro Glu 
        355                 360                 365             


Ala 
    


<210>  32
<211>  2457
<212>  DNA
<213>  Homo sapiens

<400>  32
attagatcag tgttcataag aacatctgta ggcacacata cacactctct ttacagtcag       60

ccttctgctt gccacagtca tagtgggcag tcagtgaatc ttccccaagt gctgacaatt      120

aatacctggt ttagcggcaa agattcagag aggcgtgagc agcccctctg gccttcagac      180

aaaaatctac gtaccatcag aaactatgtc tctgcagatg gtaacagtca gtaataacat      240

agccttaatt cagccaggct tctcactgat gaattttgat ggacaagttt tcttctttgg      300

acaaaaaggc tggcccaaaa gatcctgccc cactggagtt ttccatctgg atgtaaagca      360

taaccatgtc aaactgaagc ctacaatttt ctctaaggat tcctgctacc tccctcctct      420

tcgctaccca gccacttgca cattcaaagg cagcttggag tctgaaaagc atcaatacat      480

catccatgga gggaaaacac caaacaatga ggtttcagat aagatttatg tcatgtctat      540

tgtttgcaag aacaacaaaa aggttacttt tcgctgcaca gagaaagact tggtaggaga      600

tgttcctgaa gccagatatg gtcattccat taatgtggtg tacagccgag ggaaaagtat      660

gggtgttctc tttggaggac gctcatacat gccttctacc cacagaacca cagaaaaatg      720

gaatagtgta gctgactgcc tgccctgtgt tttcctggtg gattttgaat ttgggtgtgc      780

tacatcatac attcttccag aacttcagga tgggctatct tttcatgtct ctattgccaa      840

aaatgacacc atctatattt taggaggaca ttcacttgcc aataatatcc ggcctgccaa      900

cctgtacaga ataagggttg atcttcccct gggtagccca gctgtgaatt gcacagtctt      960

gccaggagga atctctgtct ccagtgcaat cctgactcaa actaacaatg atgaatttgt     1020

tattgttggt ggctatcagc ttgaaaatca aaaaagaatg atctgcaaca tcatctcttt     1080

agaggacaac aagatagaaa ttcgtgagat ggagacccca gattggaccc cagacattaa     1140

gcacagcaag atatggtttg gaagcaacat gggaaatgga actgtttttc ttggcatacc     1200

aggagacaat aaacaagttg tttcagaagg attctatttc tatatgttga aatgtgctga     1260

agatgatact aatgaagagc agacaacatt cacaaacagt caaacatcaa cagaagatcc     1320

aggggattcc actccctttg aagactctga agaattttgt ttcagtgcag aagcaaatag     1380

ttttgatggt gatgatgaat ttgacaccta taatgaagat gatgaagaag atgagtctga     1440

gacaggctac tggattacat gctgccctac ttgtgatgtg gatatcaaca cttgggtacc     1500

attctattca actgagctca acaaacccgc catgatctac tgctctcatg gggatgggca     1560

ctgggtccat gctcagtgca tggatctggc agaacgcaca ctcatccatc tgtcagcagg     1620

aagcaacaag tattactgca atgagcatgt ggagatagca agagctctac acactcccca     1680

aagagtccta cccttaaaaa agcctccaat gaaatccctc cgtaaaaaag gttctggaaa     1740

aatcttgact cctgccaaga aatcctttct tagaaggttg tttgattagt tttgcaaaag     1800

cctttcagat tcaggtgtat ggaatttttg aatctatttt taaaatcata acattgattt     1860

taaaaataca tttttgttta tttaaaatgc ctatgttttc ttttagttac atgaattaag     1920

ggccagaaaa aagtgtttat aatgcaatga taaataaagt cattctagac cctatacatt     1980

ttgaaaatat tttacccaaa tactcaattt actaatttat tcttcactga ggatttctga     2040

tctgattttt tattcaacaa accttaaaca cccagaagca gtaataatca tcgaggtatg     2100

tttatattta ttatataagt cttggtaaca aataacctat aaagtgttta tgacaaattt     2160

agccaataaa gaaattaaca cccaaaagaa ttaaattgat tattttgtgc aacataacaa     2220

ttcggcagtt ggccaaaact taaaagcaag atctactaca tcccacatta gtgttcttta     2280

tataccttca agcaaccctt tggattatgc ccatgaacaa gttagtttct catagcttta     2340

cagatgtaga tataaatata aatatatgta tacatataga tagataatgt tctccactga     2400

cacaaaagaa gaaataaata atctacatca aaaaaaaaaa aaaaaaaaaa aaaaaaa        2457


<210>  33
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Leu Gln Met Val Thr Val Ser Asn Asn Ile Ala Leu Ile Gln 
1               5                   10                  15      


Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly 
            20                  25                  30          


Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Leu 
        35                  40                  45              


Asp Val Lys His Asn His Val Lys Leu Lys Pro Thr Ile Phe Ser Lys 
    50                  55                  60                  


Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Thr Phe 
65                  70                  75                  80  


Lys Gly Ser Leu Glu Ser Glu Lys His Gln Tyr Ile Ile His Gly Gly 
                85                  90                  95      


Lys Thr Pro Asn Asn Glu Val Ser Asp Lys Ile Tyr Val Met Ser Ile 
            100                 105                 110         


Val Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp 
        115                 120                 125             


Leu Val Gly Asp Val Pro Glu Ala Arg Tyr Gly His Ser Ile Asn Val 
    130                 135                 140                 


Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser 
145                 150                 155                 160 


Tyr Met Pro Ser Thr His Arg Thr Thr Glu Lys Trp Asn Ser Val Ala 
                165                 170                 175     


Asp Cys Leu Pro Cys Val Phe Leu Val Asp Phe Glu Phe Gly Cys Ala 
            180                 185                 190         


Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val 
        195                 200                 205             


Ser Ile Ala Lys Asn Asp Thr Ile Tyr Ile Leu Gly Gly His Ser Leu 
    210                 215                 220                 


Ala Asn Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu 
225                 230                 235                 240 


Pro Leu Gly Ser Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile 
                245                 250                 255     


Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val 
            260                 265                 270         


Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Ile Cys Asn 
        275                 280                 285             


Ile Ile Ser Leu Glu Asp Asn Lys Ile Glu Ile Arg Glu Met Glu Thr 
    290                 295                 300                 


Pro Asp Trp Thr Pro Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser 
305                 310                 315                 320 


Asn Met Gly Asn Gly Thr Val Phe Leu Gly Ile Pro Gly Asp Asn Lys 
                325                 330                 335     


Gln Val Val Ser Glu Gly Phe Tyr Phe Tyr Met Leu Lys Cys Ala Glu 
            340                 345                 350         


Asp Asp Thr Asn Glu Glu Gln Thr Thr Phe Thr Asn Ser Gln Thr Ser 
        355                 360                 365             


Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe 
    370                 375                 380                 


Cys Phe Ser Ala Glu Ala Asn Ser Phe Asp Gly Asp Asp Glu Phe Asp 
385                 390                 395                 400 


Thr Tyr Asn Glu Asp Asp Glu Glu Asp Glu Ser Glu Thr Gly Tyr Trp 
                405                 410                 415     


Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro 
            420                 425                 430         


Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His 
        435                 440                 445             


Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Ala Glu Arg 
    450                 455                 460                 


Thr Leu Ile His Leu Ser Ala Gly Ser Asn Lys Tyr Tyr Cys Asn Glu 
465                 470                 475                 480 


His Val Glu Ile Ala Arg Ala Leu His Thr Pro Gln Arg Val Leu Pro 
                485                 490                 495     


Leu Lys Lys Pro Pro Met Lys Ser Leu Arg Lys Lys Gly Ser Gly Lys 
            500                 505                 510         


Ile Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp 
        515                 520                 525         


<210>  34
<211>  3393
<212>  DNA
<213>  Mus musculus

<400>  34
actctaccct gcagccttca gcttggcaca aactaaacag tgactcttcc ccaagtgccg       60

agtttaattc ctggcttggc cgaaaggatt cagagaggga taagcagccc ctctggcctt      120

cagtgccaaa ataagaaaga gtatttcaca tccacaagca ggaagtacac ttcatacctc      180

tctaagataa aagacctatt cacaatcaaa aatgtccctg cagatggtaa cagtgggtca      240

taacatagcc ttaattcaac caggcttctc acttatgaat tttgatggcc aagttttctt      300

ctttggccag aaaggctggc ctaagagatc ctgtcctact ggagtctttc attttgatat      360

aaaacaaaat catctcaaac tgaagcctgc aatcttctct aaagattcct gctacctccc      420

acctcttcgt tatccagcta cttgctcata caaaggcagc atagactctg acaagcatca      480

atatatcatt cacggaggga aaacaccaaa caatgagctt tccgataaga tttatatcat      540

gtctgtcgct tgcaagaata acaaaaaagt tactttccgt tgcacagaga aagacttagt      600

aggagatgtc cctgaaccca gatacggcca ttccattgac gtggtgtata gtcgagggaa      660

aagcatgggt gttctctttg gaggacgttc atacatgcct tctacccaga gaaccacaga      720

aaaatggaat agtgtagctg actgcctacc ccatgttttc ttgatagatt ttgaatttgg      780

gtgtgctaca tcatatattc tcccagaact tcaggatggg ctgtcttttc atgtttctat      840

tgccagaaac gataccgttt atattttggg aggacactca cttgccagta atatacgccc      900

tgctaacttg tatagaataa gagtggacct tcccctgggt accccagcag tgaattgcac      960

agtcttgcca ggaggaatct ctgtctccag tgcaatcctc actcaaacaa acaatgatga     1020

atttgttatt gtgggtggtt atcagctgga aaatcagaaa aggatggtct gcagccttgt     1080

ctctctaggg gacaacacga ttgaaatcag tgagatggag actcctgact ggacctcaga     1140

tattaagcat agcaaaatat ggtttggaag caacatggga aacgggacta ttttccttgg     1200

cataccagga gacaataagc aggctatgtc agaagcattc tatttctata ctttgagatg     1260

ctctgaagag gatttgagtg aagatcagaa aattgtctcc aacagtcaga catcaacaga     1320

agatcctggg gactccactc cctttgaaga ctcagaggaa ttttgtttca gtgctgaagc     1380

aaccagtttt gatggtgacg atgaatttga cacctacaat gaagatgatg aagatgacga     1440

gtctgtaacc ggctactgga taacatgttg ccctacttgt gatgttgaca tcaatacctg     1500

ggttccgttc tattcaacgg agctcaataa acccgccatg atctattgtt ctcatgggga     1560

tgggcactgg gtacatgccc agtgcatgga tttggaagaa cgcacactca tccacttgtc     1620

agaaggaagc aacaagtatt attgcaatga acatgtacag atagcaagag cattgcaaac     1680

tcccaaaaga aaccccccct tacaaaaacc tccaatgaaa tccctccaca aaaaaggctc     1740

tgggaaagtc ttgactcctg ccaagaaatc cttccttaga agactgtttg attaatttag     1800

caaaagcccc tcagactcag gtatattgct ctctgaatct actttcaatc ataaacatta     1860

ttttgatttt tgtttactga aatctctatg ttatgtttta gttatgtgaa ttaagtgctg     1920

ttgtgattta ttgttaagta taactattct aatgtgtgtt ttttaacatc ttatccagga     1980

atgtcttaaa tgagaaatgt tatacagttt tccattaagg atatcagtga taaagtatag     2040

aactcttaca ttattttgta acaatctaca tattgaatag taactaaata ccaataaata     2100

aactaatgca caaaaagtta agttcttttg tgtaataagt agcctatagt tggtttaaac     2160

agttaaaacc aacagctata tcccacacta ctgctgttta taaattttaa ggtggcctct     2220

ggtttatact tatgagcaga attatatata ttggtcaata ccatgaagaa aaatttaatt     2280

ctatatcaag ccaggcatgg tgatggtgat acatgcctgt aatcctggca cttaggaagt     2340

ggaagaagga agtttgtgag tttgatgctt gttgaggtat gaccttttgc tatgtattgt     2400

agtgtatgag ccccaagacc tgcttgaccc agagacaaga gagtccacac atagatccaa     2460

gtaatgctat gtgaccttgc cccccggtta cttgtgatta ggtgaataaa gatgtcaaca     2520

gccaatagct gggcagaaga gccaaaagtg gggattgagg gtaccctggc ttgatgtagg     2580

aggagaccat gaggaaaggg gagaaaaaag tgatggagga ggagaaagat gccatgagct     2640

aggagttaag aaagcatggc catgagtgct ggccaattgg agttaagagc agcccagatg     2700

aaacatagta agtaataact cagggttatc gatagaaaat agattttagt gccgtactct     2760

ccccagccct agagctgact atggcttact gtaaatataa agtttgtatg tgtcttttat     2820

ccaggaacta aatggtcaaa ggtggagtag aaactctgga ttgggattaa atttttctac     2880

aacaaatgct ggcctgggct agattttatc tcatatccga aggctgacag aacacagagc     2940

actggtaaca ttgccacctg ccatgcacaa agacctgagt ctaatactgt ggacattttc     3000

ttgaagtatc tacatgtact tctggagtga aaacatattc caacaatatg cctttgttta     3060

aatcactcac tcactttggg ccctcacatt atatcctttc aaaatcaatg gttcacccct     3120

ttgaaaatgc ttagccatag tccctcatct tccttaaaga cagttgtcat ctctggaaat     3180

agtcacatgt cattcaaggt ccaatactgt gcagctctga agtatggcat taccacttta     3240

agtgaaaagt gaaatatgaa catgagctca gacaaaggtt tgggactatc actctcaagg     3300

aggctctact gctaagtcct gaactgcttt cacatgaata cagaaattat aacaaaaaat     3360

atgtaatcaa taaaaagaaa actttcatat tcc                                  3393


<210>  35
<211>  527
<212>  PRT
<213>  Mus musculus

<400>  35

Met Ser Leu Gln Met Val Thr Val Gly His Asn Ile Ala Leu Ile Gln 
1               5                   10                  15      


Pro Gly Phe Ser Leu Met Asn Phe Asp Gly Gln Val Phe Phe Phe Gly 
            20                  25                  30          


Gln Lys Gly Trp Pro Lys Arg Ser Cys Pro Thr Gly Val Phe His Phe 
        35                  40                  45              


Asp Ile Lys Gln Asn His Leu Lys Leu Lys Pro Ala Ile Phe Ser Lys 
    50                  55                  60                  


Asp Ser Cys Tyr Leu Pro Pro Leu Arg Tyr Pro Ala Thr Cys Ser Tyr 
65                  70                  75                  80  


Lys Gly Ser Ile Asp Ser Asp Lys His Gln Tyr Ile Ile His Gly Gly 
                85                  90                  95      


Lys Thr Pro Asn Asn Glu Leu Ser Asp Lys Ile Tyr Ile Met Ser Val 
            100                 105                 110         


Ala Cys Lys Asn Asn Lys Lys Val Thr Phe Arg Cys Thr Glu Lys Asp 
        115                 120                 125             


Leu Val Gly Asp Val Pro Glu Pro Arg Tyr Gly His Ser Ile Asp Val 
    130                 135                 140                 


Val Tyr Ser Arg Gly Lys Ser Met Gly Val Leu Phe Gly Gly Arg Ser 
145                 150                 155                 160 


Tyr Met Pro Ser Thr Gln Arg Thr Thr Glu Lys Trp Asn Ser Val Ala 
                165                 170                 175     


Asp Cys Leu Pro His Val Phe Leu Ile Asp Phe Glu Phe Gly Cys Ala 
            180                 185                 190         


Thr Ser Tyr Ile Leu Pro Glu Leu Gln Asp Gly Leu Ser Phe His Val 
        195                 200                 205             


Ser Ile Ala Arg Asn Asp Thr Val Tyr Ile Leu Gly Gly His Ser Leu 
    210                 215                 220                 


Ala Ser Asn Ile Arg Pro Ala Asn Leu Tyr Arg Ile Arg Val Asp Leu 
225                 230                 235                 240 


Pro Leu Gly Thr Pro Ala Val Asn Cys Thr Val Leu Pro Gly Gly Ile 
                245                 250                 255     


Ser Val Ser Ser Ala Ile Leu Thr Gln Thr Asn Asn Asp Glu Phe Val 
            260                 265                 270         


Ile Val Gly Gly Tyr Gln Leu Glu Asn Gln Lys Arg Met Val Cys Ser 
        275                 280                 285             


Leu Val Ser Leu Gly Asp Asn Thr Ile Glu Ile Ser Glu Met Glu Thr 
    290                 295                 300                 


Pro Asp Trp Thr Ser Asp Ile Lys His Ser Lys Ile Trp Phe Gly Ser 
305                 310                 315                 320 


Asn Met Gly Asn Gly Thr Ile Phe Leu Gly Ile Pro Gly Asp Asn Lys 
                325                 330                 335     


Gln Ala Met Ser Glu Ala Phe Tyr Phe Tyr Thr Leu Arg Cys Ser Glu 
            340                 345                 350         


Glu Asp Leu Ser Glu Asp Gln Lys Ile Val Ser Asn Ser Gln Thr Ser 
        355                 360                 365             


Thr Glu Asp Pro Gly Asp Ser Thr Pro Phe Glu Asp Ser Glu Glu Phe 
    370                 375                 380                 


Cys Phe Ser Ala Glu Ala Thr Ser Phe Asp Gly Asp Asp Glu Phe Asp 
385                 390                 395                 400 


Thr Tyr Asn Glu Asp Asp Glu Asp Asp Glu Ser Val Thr Gly Tyr Trp 
                405                 410                 415     


Ile Thr Cys Cys Pro Thr Cys Asp Val Asp Ile Asn Thr Trp Val Pro 
            420                 425                 430         


Phe Tyr Ser Thr Glu Leu Asn Lys Pro Ala Met Ile Tyr Cys Ser His 
        435                 440                 445             


Gly Asp Gly His Trp Val His Ala Gln Cys Met Asp Leu Glu Glu Arg 
    450                 455                 460                 


Thr Leu Ile His Leu Ser Glu Gly Ser Asn Lys Tyr Tyr Cys Asn Glu 
465                 470                 475                 480 


His Val Gln Ile Ala Arg Ala Leu Gln Thr Pro Lys Arg Asn Pro Pro 
                485                 490                 495     


Leu Gln Lys Pro Pro Met Lys Ser Leu His Lys Lys Gly Ser Gly Lys 
            500                 505                 510         


Val Leu Thr Pro Ala Lys Lys Ser Phe Leu Arg Arg Leu Phe Asp 
        515                 520                 525         


<210>  36
<211>  1810
<212>  DNA
<213>  Homo sapiens

<400>  36
gagaccaaaa gtcaggtagg agcctccggg gtccctgctg tgtcacccgg acaggccgtg       60

ggggcgggca ggggggcggg gccgggcctg accacagcgg ccgagttcag tcctgctctc      120

cgcacgccac cttaggcccg cagccgtgcc gggtgctctt cagcatgtcc ttcatcccgg      180

tggccgagga ttccgacttc cccatccaca acctgcccta cggcgtcttc tcgaccagag      240

gcgacccaag accgaggata ggtgtggcca ttggcgacca gatcctggac ctcagcatca      300

tcaagcacct ctttactggt cctgtcctct ccaaacacca ggatgtcttc aatcagccta      360

cactcaacag cttcatgggc ctgggtcagg ctgcctggaa ggaggcgaga gtgttcttgc      420

agaacttgct gtctgtgagc caagccaggc tcagagatga caccgaactt cggaagtgtg      480

cattcatctc ccaggcttct gccacgatgc accttccagc caccatagga gactacacag      540

acttctattc ctctcggcag catgctacca acgtcggaat catgttcagg gacaaggaga      600

atgcgttgat gccaaattgg ctgcacttac cagtgggcta ccatggccgt gcctcctctg      660

tcgtggtgtc tggcacccca atccgaaggc ccatgggaca gatgaaacct gatgactcta      720

agcctcccgt atatggtgcc tgcaagctct tggacatgga gctggaaatg gctttttttg      780

taggccctgg aaacagattg ggagagccga tccccatttc caaggcccat gagcacattt      840

ttggaatggt ccttatgaac gactggagtg cacgagacat tcagaagtgg gagtatgtcc      900

ctctcgggcc attccttggg aagagttttg ggaccactgt ctctccgtgg gtggtgccca      960

tggatgctct catgcccttt gctgtgccca acccgaagca ggaccccagg cccctgccgt     1020

atctgtgcca tgacgagccc tacacatttg acatcaacct ctctgttaac ctgaaaggag     1080

aaggaatgag ccaggcggct accatatgca agtccaattt taagtacatg tactggacga     1140

tgctgcagca gctcactcac cactctgtca acggctgcaa cctgcggccg ggggacctcc     1200

tggcttctgg gaccatcagc gggccggagc cagaaaactt cggctccatg ttggaactgt     1260

cgtggaaggg aacgaagccc atagacctgg ggaatggtca gaccaggaag tttctgctgg     1320

acggggatga agtcatcata acagggtact gccaggggga tggttaccgc atcggctttg     1380

gccagtgtgc tggaaaagtg ctgcctgctc tcctgccatc atgagatttt ctctgctctt     1440

ctggaaacaa agggctcaag cacccctttc aaccctgtga ctggggtcct ccctcgggct     1500

gtaggcctgg tccgccattc agtgacaaat aaagccattg tgctctgagg cctgcactgc     1560

cgcagatgca gctgtgtcca cttatgatcg tgatttgatc cagtgggtca aggtgtgtaa     1620

agcctccctg ccagatattc attaatatgt tttctcactc ttattagtga ggtcaggggt     1680

ctttgtggga ttttcttatt agacatccca ggcctcctgg tattccatgg aatttgaaaa     1740

gagactggca cctgtagtag tcagggctct ccagagaaat agaaccaagg agaaagaaaa     1800

aaaaaaaaaa                                                            1810


<210>  37
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ser Phe Ile Pro Val Ala Glu Asp Ser Asp Phe Pro Ile His Asn 
1               5                   10                  15      


Leu Pro Tyr Gly Val Phe Ser Thr Arg Gly Asp Pro Arg Pro Arg Ile 
            20                  25                  30          


Gly Val Ala Ile Gly Asp Gln Ile Leu Asp Leu Ser Ile Ile Lys His 
        35                  40                  45              


Leu Phe Thr Gly Pro Val Leu Ser Lys His Gln Asp Val Phe Asn Gln 
    50                  55                  60                  


Pro Thr Leu Asn Ser Phe Met Gly Leu Gly Gln Ala Ala Trp Lys Glu 
65                  70                  75                  80  


Ala Arg Val Phe Leu Gln Asn Leu Leu Ser Val Ser Gln Ala Arg Leu 
                85                  90                  95      


Arg Asp Asp Thr Glu Leu Arg Lys Cys Ala Phe Ile Ser Gln Ala Ser 
            100                 105                 110         


Ala Thr Met His Leu Pro Ala Thr Ile Gly Asp Tyr Thr Asp Phe Tyr 
        115                 120                 125             


Ser Ser Arg Gln His Ala Thr Asn Val Gly Ile Met Phe Arg Asp Lys 
    130                 135                 140                 


Glu Asn Ala Leu Met Pro Asn Trp Leu His Leu Pro Val Gly Tyr His 
145                 150                 155                 160 


Gly Arg Ala Ser Ser Val Val Val Ser Gly Thr Pro Ile Arg Arg Pro 
                165                 170                 175     


Met Gly Gln Met Lys Pro Asp Asp Ser Lys Pro Pro Val Tyr Gly Ala 
            180                 185                 190         


Cys Lys Leu Leu Asp Met Glu Leu Glu Met Ala Phe Phe Val Gly Pro 
        195                 200                 205             


Gly Asn Arg Leu Gly Glu Pro Ile Pro Ile Ser Lys Ala His Glu His 
    210                 215                 220                 


Ile Phe Gly Met Val Leu Met Asn Asp Trp Ser Ala Arg Asp Ile Gln 
225                 230                 235                 240 


Lys Trp Glu Tyr Val Pro Leu Gly Pro Phe Leu Gly Lys Ser Phe Gly 
                245                 250                 255     


Thr Thr Val Ser Pro Trp Val Val Pro Met Asp Ala Leu Met Pro Phe 
            260                 265                 270         


Ala Val Pro Asn Pro Lys Gln Asp Pro Arg Pro Leu Pro Tyr Leu Cys 
        275                 280                 285             


His Asp Glu Pro Tyr Thr Phe Asp Ile Asn Leu Ser Val Asn Leu Lys 
    290                 295                 300                 


Gly Glu Gly Met Ser Gln Ala Ala Thr Ile Cys Lys Ser Asn Phe Lys 
305                 310                 315                 320 


Tyr Met Tyr Trp Thr Met Leu Gln Gln Leu Thr His His Ser Val Asn 
                325                 330                 335     


Gly Cys Asn Leu Arg Pro Gly Asp Leu Leu Ala Ser Gly Thr Ile Ser 
            340                 345                 350         


Gly Pro Glu Pro Glu Asn Phe Gly Ser Met Leu Glu Leu Ser Trp Lys 
        355                 360                 365             


Gly Thr Lys Pro Ile Asp Leu Gly Asn Gly Gln Thr Arg Lys Phe Leu 
    370                 375                 380                 


Leu Asp Gly Asp Glu Val Ile Ile Thr Gly Tyr Cys Gln Gly Asp Gly 
385                 390                 395                 400 


Tyr Arg Ile Gly Phe Gly Gln Cys Ala Gly Lys Val Leu Pro Ala Leu 
                405                 410                 415     


Leu Pro Ser 
            


<210>  38
<211>  1597
<212>  DNA
<213>  Mus musculus

<400>  38
gggtgctaaa agaatcacta gggtggggag gcggtcccag tggggcgggt aggggtgtgt       60

gccaggtggt accgggtatt ggctggagga agggcagccc ggggttcggg gcggtccctg      120

aatctaaagg ccctcggcta gtctgatcct tgccctaagc atagtcccgt tagccaaccc      180

cctacccgcc gtgggctctg ctgcccggtg ctcgtcagca tgtcctttat tccagtggcc      240

gaggactccg actttcccat ccaaaacctg ccctatggtg ttttctccac tcaaagcaac      300

ccaaagccac ggattggtgt agccatcggt gaccagatct tggacctgag tgtcattaaa      360

cacctcttta ccggacctgc cctttccaaa catcaacatg tcttcgatga gacaactctc      420

aataacttca tgggtctggg tcaagctgca tggaaggagg caagagcatc cttacagaac      480

ttactgtctg ccagccaagc ccggctcaga gatgacaagg agcttcggca gcgtgcattc      540

acctcccagg cttctgcgac aatgcacctt cctgctacca taggagacta cacggacttc      600

tactcttctc ggcagcatgc caccaatgtt ggcattatgt tcagaggcaa ggagaatgcg      660

ctgttgccaa attggctcca cttacctgtg ggataccatg gccgagcttc ctccattgtg      720

gtatctggaa ccccgattcg aagacccatg gggcagatga gacctgataa ctcaaagcct      780

cctgtgtatg gtgcctgcag actcttagac atggagttgg aaatggcttt cttcgtaggc      840

cctgggaaca gattcggaga gccaatcccc atttccaaag cccatgaaca cattttcggg      900

atggtcctca tgaacgactg gagcgcacga gacatccagc aatgggagta cgtcccactt      960

gggccattcc tggggaaaag ctttggaacc acaatctccc cgtgggtggt gcctatggat     1020

gccctcatgc cctttgtggt gccaaaccca aagcaggacc ccaagccctt gccatatctc     1080

tgccacagcc agccctacac atttgatatc aacctgtctg tctctttgaa aggagaagga     1140

atgagccagg cggctaccat ctgcaggtct aactttaagc acatgtactg gaccatgctg     1200

cagcaactca cacaccactc tgttaatgga tgcaacctga gacctgggga cctcttggct     1260

tctggaacca tcagtggatc agaccctgaa agctttggct ccatgctgga actgtcctgg     1320

aagggaacaa aggccatcga tgtggagcag gggcagacca ggaccttcct gctggacggc     1380

gatgaagtca tcataacagg tcactgccag ggggacggct accgtgttgg ctttggccag     1440

tgtgctggga aagtgctgcc tgccctttca ccagcctgaa gctccggaag tcacaagaca     1500

cacccttgcc ttatgaggat catgctacca ctgcatcagt caggaatgaa taaagctact     1560

ttgattgtgg gaaatgccac agaaaaaaaa aaaaaaa                              1597


<210>  39
<211>  419
<212>  PRT
<213>  Mus musculus

<400>  39

Met Ser Phe Ile Pro Val Ala Glu Asp Ser Asp Phe Pro Ile Gln Asn 
1               5                   10                  15      


Leu Pro Tyr Gly Val Phe Ser Thr Gln Ser Asn Pro Lys Pro Arg Ile 
            20                  25                  30          


Gly Val Ala Ile Gly Asp Gln Ile Leu Asp Leu Ser Val Ile Lys His 
        35                  40                  45              


Leu Phe Thr Gly Pro Ala Leu Ser Lys His Gln His Val Phe Asp Glu 
    50                  55                  60                  


Thr Thr Leu Asn Asn Phe Met Gly Leu Gly Gln Ala Ala Trp Lys Glu 
65                  70                  75                  80  


Ala Arg Ala Ser Leu Gln Asn Leu Leu Ser Ala Ser Gln Ala Arg Leu 
                85                  90                  95      


Arg Asp Asp Lys Glu Leu Arg Gln Arg Ala Phe Thr Ser Gln Ala Ser 
            100                 105                 110         


Ala Thr Met His Leu Pro Ala Thr Ile Gly Asp Tyr Thr Asp Phe Tyr 
        115                 120                 125             


Ser Ser Arg Gln His Ala Thr Asn Val Gly Ile Met Phe Arg Gly Lys 
    130                 135                 140                 


Glu Asn Ala Leu Leu Pro Asn Trp Leu His Leu Pro Val Gly Tyr His 
145                 150                 155                 160 


Gly Arg Ala Ser Ser Ile Val Val Ser Gly Thr Pro Ile Arg Arg Pro 
                165                 170                 175     


Met Gly Gln Met Arg Pro Asp Asn Ser Lys Pro Pro Val Tyr Gly Ala 
            180                 185                 190         


Cys Arg Leu Leu Asp Met Glu Leu Glu Met Ala Phe Phe Val Gly Pro 
        195                 200                 205             


Gly Asn Arg Phe Gly Glu Pro Ile Pro Ile Ser Lys Ala His Glu His 
    210                 215                 220                 


Ile Phe Gly Met Val Leu Met Asn Asp Trp Ser Ala Arg Asp Ile Gln 
225                 230                 235                 240 


Gln Trp Glu Tyr Val Pro Leu Gly Pro Phe Leu Gly Lys Ser Phe Gly 
                245                 250                 255     


Thr Thr Ile Ser Pro Trp Val Val Pro Met Asp Ala Leu Met Pro Phe 
            260                 265                 270         


Val Val Pro Asn Pro Lys Gln Asp Pro Lys Pro Leu Pro Tyr Leu Cys 
        275                 280                 285             


His Ser Gln Pro Tyr Thr Phe Asp Ile Asn Leu Ser Val Ser Leu Lys 
    290                 295                 300                 


Gly Glu Gly Met Ser Gln Ala Ala Thr Ile Cys Arg Ser Asn Phe Lys 
305                 310                 315                 320 


His Met Tyr Trp Thr Met Leu Gln Gln Leu Thr His His Ser Val Asn 
                325                 330                 335     


Gly Cys Asn Leu Arg Pro Gly Asp Leu Leu Ala Ser Gly Thr Ile Ser 
            340                 345                 350         


Gly Ser Asp Pro Glu Ser Phe Gly Ser Met Leu Glu Leu Ser Trp Lys 
        355                 360                 365             


Gly Thr Lys Ala Ile Asp Val Glu Gln Gly Gln Thr Arg Thr Phe Leu 
    370                 375                 380                 


Leu Asp Gly Asp Glu Val Ile Ile Thr Gly His Cys Gln Gly Asp Gly 
385                 390                 395                 400 


Tyr Arg Val Gly Phe Gly Gln Cys Ala Gly Lys Val Leu Pro Ala Leu 
                405                 410                 415     


Ser Pro Ala 
            


<210>  40
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  II2-rg WT-guide RNA

<400>  40
tccaaggtcc tcatgtccag tgcgaatgaa gacatcaagc ttatccctgt tggcacatgg       60

ggttgattat ta                                                           72


<210>  41
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Il2-rg genomic deletion

<400>  41
tccaaggttg attatta                                                      17


<210>  42
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Rag2 WT- guide RNA

<400>  42
ccagatacgg ccattccatt gacgtggcct gggttccgtt ctattcaacg gagc             54


<210>  43
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Rag2 gene Deletion-1 guide RNA

<400>  43
ccagatacgg ccattccatt ctattcaacg gagc                                   34


<210>  44
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Rag2 genomic Deletion-2 guide RNA

<400>  44
ccagatacgg ccattcaacg gagc                                              24


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Rag2 genomic Deletion-3 guide RNA

<400>  45
aagttactat tcaacggagc                                                   20


<210>  46
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Rag2 genomic Deletion-4 guide RNA

<400>  46
ccagatacgg ccatattcaa cggagc                                            26


<210>  47
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
gtgcccctga ttctgtttca gtgcattatg ttgggcatta tgttcagagg ca               52


<210>  48
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Fah genomic Deletion-1 guide RNA

<400>  48
gtgcccctga ttctgtttca gtgcattatg ttgggcatta tgttcagagg ca               52


<210>  49
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Fah genomic Deletion-2 guide RNA

<400>  49
gtgcccctga ttctgtttca gtgcattatg ttcagaggca                             40


<210>  50
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<223>  Il2rg-/- Del-1, Frame shift mutation from aminoacid 28

<400>  50

Leu Cys Trp His Tyr Val Gln Arg Gln Gly Glu Cys Ala Val Ala Lys 
1               5                   10                  15      


Leu Ala Pro Leu Thr Cys Gly Ile Pro Trp Pro Ser Phe Leu His Cys 
            20                  25                  30          


Gly Ile Trp Asn Pro Asp Ser Lys Thr His Gly Ala Asp Glu Thr 
        35                  40                  45          


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Rag2-/- Del-1; Frame shift from aminoacid 143

<400>  51

Ile Leu Phe Asn Gly Ala Gln 
1               5           


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Rag2-/- Del-2; Frame shift from aminoacid 141

<400>  52

Ile Gln Arg Ser Ser Ile Asn Pro Pro 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Rag2-/- Del-3; Frame shift from aminoacid 122

<400>  53

Ile Gln Arg Ser Ser Ile Asn Pro Pro 
1               5                   


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Rag2-/- Del-4; Frame shift from aminoacid 142

<400>  54

Thr Lys Lys Ala Leu Gly Lys Ser 
1               5               


<210>  55
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Fah-/- Del-1; Frame shift from aminoacid 107

<400>  55

Leu Cys Trp His Tyr Val Gln Arg Gln Gly Glu Cys Ala Val Ala Lys 
1               5                   10                  15      


Leu Ala Pro Leu Thr Cys Gly Ile Pro Trp Pro Ser Phe Leu His Cys 
            20                  25                  30          


Gly Ile Trp Asn Pro Asp Ser Lys Thr His Gly Ala Asp Glu Thr 
        35                  40                  45          


<210>  56
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Fah-/- Del-2; Frame shift from aminoacid 107

<400>  56

Leu Cys Ser Glu Ala Arg Arg Met Arg Cys Cys Gln Ile Gly Ser Thr 
1               5                   10                  15      


Tyr Leu Trp Asp Thr Met Ala Glu Leu Pro Pro Leu Trp Leu Glu Pro 
            20                  25                  30          


Arg Phe Glu Asp Pro Trp Gly Arg 
        35                  40  


