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<110>  PHOTEOMIX
 
<120>  BIOMARQUEUR POUR LE DIAGNOSTIC DE MALADIES INFLAMMATOIRES

<130>  WOB 15 BY PHO AKPE

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X est un acide amin naturel ou non naturel

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X est un acide amin naturel ou non naturel

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X est S ou T

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X est un acide amin naturel choisi parmi L, F, V, I, Q, R, M, K, 
       H et C ou un acide amin non naturel de caractre hydrophobe et 
       d'un poids molculaire de 100  200 Da

<400>  1

Arg Xaa Xaa Xaa Xaa 
1               5   


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X est un acide amin naturel ou non naturel

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X est un acide amin naturel ou non naturel

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X est un acide amin naturel ou non naturel

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X est un acide amin naturel ou non naturel

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X est S ou T

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X est un acide amin naturel choisi parmi L, F, V, I, Q, R, M, K, 
       H et C ou un acide amin non naturel de caractre hydrophobe et 
       d'un poids molculaire de 100  200 Da

<400>  2

Arg Xaa Xaa Arg Xaa Xaa Xaa Xaa 
1               5               


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X est un acide amin naturel ou non naturel

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X est un acide amin naturel ou non naturel

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X est un acide amin naturel ou non naturel

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X est S ou T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X est un acide amin naturel choisi parmi L, F, V, I, Q, R, M, K, 
       H et C ou un acide amin non naturel de caractre hydrophobe et 
       d'un poids molculaire de 100  200 Da

<400>  3

Arg Xaa Arg Xaa Xaa Xaa Xaa 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  4

Leu Arg Arg Ala Ser Leu Gly 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  5

Pro Arg Arg Pro Ser Leu Gly 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  6

Leu Pro Arg Arg Pro Ser Ile 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  7

Pro Arg Arg Ala Ser Leu Gly 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  8

Pro Arg Arg Trp Ser Leu Gly 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  9

Pro Arg Arg Lys Ser Leu Gly 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  10

Pro Arg Arg Leu Ser Leu Gly 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  11

Pro Arg Arg Arg Ser Leu Gly 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  12

Pro Arg Arg Thr Ser Leu Gly 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  13

Pro Arg Arg Gly Ser Leu Gly 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  14

Pro Arg Arg Glu Ser Leu Gly 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  15

Pro Arg Arg Ser Ser Leu Gly 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  16

Pro Arg Arg Tyr Ser Leu Gly 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  17

Pro Arg Arg His Ser Leu Gly 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  18

Pro Arg Arg Val Ser Leu Gly 
1               5           


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  19

Pro Arg Arg Asn Ser Leu Gly 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  20

Pro Arg Arg Cys Ser Leu Gly 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  21

Pro Arg Arg Gln Ser Leu Gly 
1               5           


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  22

Pro Arg Arg Asp Ser Leu Gly 
1               5           


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  23

Pro Arg Arg Ala Ser Phe Gly 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  24

Pro Arg Arg Ala Ser Val Gly 
1               5           


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  25

Pro Arg Arg Ala Ser Ile Gly 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  26

Pro Arg Arg Ala Ser Met Gly 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  27

Pro Arg Arg Ala Ser Gln Gly 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  28

Pro Arg Arg Ala Ser Asn Gly 
1               5           


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  29

Pro Arg Arg Ala Ser Cys Gly 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  30

Arg Asp Leu Arg Arg Ala Ser Leu Val 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  31

Arg Tyr Leu Arg Arg Ala Thr Leu Val 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  32

Arg Tyr Leu Arg Arg Pro Ser Leu Gly 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  33

Arg Pro Pro Arg Arg Ala Ser Leu Gly 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Y est sous la forme D-isomre

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  L est sous la forme D-isomre

<400>  34

Arg Tyr Leu Arg Arg Ala Ser Leu Gly 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Y est sous la forme D-isomre

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  L est sous la forme D-isomre

<400>  35

Arg Tyr Leu Arg Arg Pro Ser Leu Gly 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  36

Arg Pro Pro Arg Lys Ala Ser Leu Gly 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  37

Arg Pro Pro Arg Arg Pro Ser Leu Gly 
1               5                   


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  38

Arg Pro Pro Arg Arg Pro Ser Ile 
1               5               


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  39

Pro Arg Arg Pro Thr Ile 
1               5       


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  40

Arg Tyr Leu Arg Arg Ala Ser Leu Gly 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X est un acide amin naturel

<400>  41

Val Asp Pro Arg Arg Ala Ser Xaa Gly 
1               5                   


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  42

Arg Arg Ala Ser Gly Gly 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  43

Arg Arg Ala Ser Ala Gly 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  44

Arg Arg Ala Ser Val Gly 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  45

Arg Arg Ala Ser Leu Gly 
1               5       


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  46

Arg Arg Ala Ser Ile Gly 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  47

Arg Arg Ala Ser Phe Gly 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  48

Arg Arg Ala Ser Trp Gly 
1               5       


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  49

Arg Arg Ala Ser Pro Gly 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  50

Arg Arg Ala Ser Tyr Gly 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  51

Arg Arg Ala Ser Cys Gly 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  52

Arg Arg Ala Ser Gln Gly 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  53

Arg Arg Ala Ser Ser Gly 
1               5       


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  54

Arg Arg Ala Ser Thr Gly 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  55

Arg Arg Ala Ser Lys Gly 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  56

Arg Arg Ala Ser Arg Gly 
1               5       


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  57

Arg Arg Ala Ser His Gly 
1               5       


<210>  58
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  58

Arg Arg Ala Ser Glu Gly 
1               5       


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide substrat

<400>  59

Arg Arg Ala Ser Asp Gly 
1               5       


<210>  60
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gly Asn Ala Ala Ala Ala Lys Lys Gly Ser Glu Gln Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Ser Pro Ala Gln Asn Thr Ala His Leu Asp Gln Phe Glu Arg Ile Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Glu Thr Gly Asn His Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Lys Leu Glu Phe Ser Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


Gln Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Asn Asp Ile Lys Asn His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Lys 
305                 310                 315                 320 


Gly Pro Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile 
                325                 330                 335     


Arg Val Ser Ile Asn Glu Lys Cys Gly Lys Glu Phe Ser Glu Phe 
            340                 345                 350     


<210>  61
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Gly Asn Ala Ala Thr Ala Lys Lys Gly Ser Glu Val Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Asn Pro Thr Gln Asn Asn Ala Gly Leu Glu Asp Phe Glu Arg Lys Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Ala Thr Glu Gln Tyr Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Arg Leu Glu Tyr Ala Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


His Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Ser Asp Ile Lys Thr His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Arg 
305                 310                 315                 320 


Gly Ser Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Asp Ile 
                325                 330                 335     


Arg Val Ser Ile Thr Glu Lys Cys Ala Lys Glu Phe Gly Glu Phe 
            340                 345                 350     


<210>  62
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gly Asn Ala Pro Ala Lys Lys Asp Thr Glu Gln Glu Glu Ser Val 
1               5                   10                  15      


Asn Glu Phe Leu Ala Lys Ala Arg Gly Asp Phe Leu Tyr Arg Trp Gly 
            20                  25                  30          


Asn Pro Ala Gln Asn Thr Ala Ser Ser Asp Gln Phe Glu Arg Leu Arg 
        35                  40                  45              


Thr Leu Gly Met Gly Ser Phe Gly Arg Val Met Leu Val Arg His Gln 
    50                  55                  60                  


Glu Thr Gly Gly His Tyr Ala Met Lys Ile Leu Asn Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Met Lys Gln Val Glu His Ile Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Ile Asp Phe Pro Phe Leu Val Lys Leu Gln Phe Ser Phe Lys 
            100                 105                 110         


Asp Asn Ser Tyr Leu Tyr Leu Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser Arg Leu Gln Arg Val Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Cys Phe Tyr Ala Ala Gln Val Val Leu Ala Val Gln Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile His Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


Gln Gln Gly Tyr Leu Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Val Gly Phe Pro Pro Phe Tyr 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Arg Val 
                245                 250                 255     


Arg Phe Pro Ser Lys Leu Ser Ser Asp Leu Lys His Leu Leu Arg Ser 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Arg Asn Gly 
        275                 280                 285             


Val Gly Asp Ile Lys Asn His Lys Trp Phe Ala Thr Thr Ser Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Glu Lys Lys Val Glu Ala Pro Phe Ile Pro Lys Tyr Thr 
305                 310                 315                 320 


Gly Pro Gly Asp Ala Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Leu 
                325                 330                 335     


Arg Ile Ser Ile Asn Glu Lys Cys Ala Lys Glu Phe Ser Glu Phe 
            340                 345                 350     


