                         SEQUENCE LISTING

<110>  AiCuris Anti-infective Cures GmbH
 
<120>  HCMV entry inhibitors

<130>  A75124WO

<140>  -
<141>  2017-06-27

<150>  EP16176520.1
<151>  2016-06-27

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  2
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
1               5                   10                  15      


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
            20                  25                  30          


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
        35                  40                  45              


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
    50                  55                  60                  


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
65                  70                  75                  80  


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
                85                  90                  95      


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
            100                 105                 110         


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Cys Arg 
        115                 120                 125             


Thr Thr Asp Pro Glu Thr Pro Val Thr Leu His Asn Ser Glu Gly Val 
    130                 135                 140                 


Val Pro Ala Ser Tyr Asp Ser Arg Gln Gly Phe Asn Gly Thr Phe Thr 
145                 150                 155                 160 


Val Gly Pro Tyr Ile Cys Glu Ala Thr Val Lys Gly Lys Lys Phe Gln 
                165                 170                 175     


Thr Ile Pro Phe Asn Val Tyr Ala Leu Lys Ala Thr Ser Glu Leu Asp 
            180                 185                 190         


Leu Glu Met Glu Ala Leu Lys Thr Val Tyr Lys Ser Gly Glu Thr Ile 
        195                 200                 205             


Val Val Thr Cys Ala Val Phe Asn Asn Glu Val Val Asp Leu Gln Trp 
    210                 215                 220                 


Thr Tyr Pro Gly Glu Val Lys Gly Lys Gly Ile Thr Met Leu Glu Glu 
225                 230                 235                 240 


Ile Lys Val Pro Ser Ile Lys Leu Val Tyr Thr Leu Thr Val Pro Glu 
                245                 250                 255     


Ala Thr Val Lys Asp Ser Gly Asp Tyr Glu Cys Ala Ala Arg Gln Ala 
            260                 265                 270         


Thr Arg Glu Val Lys Glu Met Lys Lys Val Thr Ile Ser Val His Glu 
        275                 280                 285             


Lys Gly Phe Ile Glu Ile Lys Pro Thr Phe Ser Gln Leu Glu Ala Val 
    290                 295                 300                 


Asn Leu His Glu Val Lys His Phe Val Val Glu Val Arg Ala Tyr Pro 
305                 310                 315                 320 


Pro Pro Arg Ile Ser Trp Leu Lys Asn Asn Leu Thr Leu Ile Glu Asn 
                325                 330                 335     


Leu Thr Glu Ile Thr Thr Asp Val Glu Lys Ile Gln Glu Ile Arg Tyr 
            340                 345                 350         


Arg Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly His 
        355                 360                 365             


Tyr Thr Ile Val Ala Gln Asn Glu Asp Ala Val Lys Ser Tyr Thr Phe 
    370                 375                 380                 


Glu Leu Leu Thr Gln Val Pro Ser Ser Ile Leu Asp Leu Val Asp Asp 
385                 390                 395                 400 


His His Gly Ser Thr Gly Gly Gln Thr Val Arg Cys Thr Ala Glu Gly 
                405                 410                 415     


Thr Pro Leu Pro Asp Ile Glu Trp Met Ile Cys Lys Asp Ile Lys Lys 
            420                 425                 430         


Cys Asn Asn Glu Thr Ser Trp Thr Ile Leu Ala Asn Asn Val Ser Asn 
        435                 440                 445             


Ile Ile Thr Glu Ile His Ser Arg Asp Arg Ser Thr Val Glu Gly Arg 
    450                 455                 460                 


Val Thr Phe Ala Lys Val Glu Glu Thr Ile Ala Val Arg Cys Leu Ala 
465                 470                 475                 480 


Lys Asn Leu Leu Gly Ala Glu Asn Arg Glu Leu Lys Leu Val Ala Pro 
                485                 490                 495     


Thr Leu Arg Ser Glu 
            500     


<210>  3
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
1               5                   10                  15      


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
            20                  25                  30          


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
        35                  40                  45              


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
    50                  55                  60                  


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
65                  70                  75                  80  


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
                85                  90                  95      


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
            100                 105                 110         


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Glu Ala 
        115                 120                 125             


Thr Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala 
    130                 135                 140                 


Leu Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr 
145                 150                 155                 160 


Val Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn 
                165                 170                 175     


Asn Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly 
            180                 185                 190         


Lys Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu 
        195                 200                 205             


Val Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp 
    210                 215                 220                 


Tyr Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys 
225                 230                 235                 240 


Lys Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro 
                245                 250                 255     


Thr Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe 
            260                 265                 270         


Val Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys 
        275                 280                 285             


Asn Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val 
    290                 295                 300                 


Glu Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg 
305                 310                 315                 320 


Ala Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu 
                325                 330                 335     


Asp Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser 
            340                 345                 350         


Ser Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln 
        355                 360                 365             


Thr Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp 
    370                 375                 380                 


Met Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr 
385                 390                 395                 400 


Ile Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg 
                405                 410                 415     


Asp Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu 
            420                 425                 430         


Thr Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn 
        435                 440                 445             


Arg Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu 
    450                 455                 460     


<210>  4
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
1               5                   10                  15      


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
            20                  25                  30          


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
        35                  40                  45              


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
    50                  55                  60                  


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
65                  70                  75                  80  


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
                85                  90                  95      


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
            100                 105                 110         


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Cys Ala 
        115                 120                 125             


Val Phe Asn Asn Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu 
    130                 135                 140                 


Val Lys Gly Lys Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser 
145                 150                 155                 160 


Ile Lys Leu Val Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp 
                165                 170                 175     


Ser Gly Asp Tyr Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys 
            180                 185                 190         


Glu Met Lys Lys Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu 
        195                 200                 205             


Ile Lys Pro Thr Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val 
    210                 215                 220                 


Lys His Phe Val Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser 
225                 230                 235                 240 


Trp Leu Lys Asn Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr 
                245                 250                 255     


Thr Asp Val Glu Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys 
            260                 265                 270         


Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala 
        275                 280                 285             


Gln Asn Glu Asp Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln 
    290                 295                 300                 


Val Pro Ser Ser Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr 
305                 310                 315                 320 


Gly Gly Gln Thr Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp 
                325                 330                 335     


Ile Glu Trp Met Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr 
            340                 345                 350         


Ser Trp Thr Ile Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile 
        355                 360                 365             


His Ser Arg Asp Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys 
    370                 375                 380                 


Val Glu Glu Thr Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly 
385                 390                 395                 400 


Ala Glu Asn Arg Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu 
                405                 410                 415     


<210>  5
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
1               5                   10                  15      


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
            20                  25                  30          


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
        35                  40                  45              


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
    50                  55                  60                  


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
65                  70                  75                  80  


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
                85                  90                  95      


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
            100                 105                 110         


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Ala Ala 
        115                 120                 125             


Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys Val Thr Ile Ser 
    130                 135                 140                 


Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr Phe Ser Gln Leu 
145                 150                 155                 160 


Glu Ala Val Asn Leu His Glu Val Lys His Phe Val Val Glu Val Arg 
                165                 170                 175     


Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn Asn Leu Thr Leu 
            180                 185                 190         


Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu Lys Ile Gln Glu 
        195                 200                 205             


Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp 
    210                 215                 220                 


Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp Ala Val Lys Ser 
225                 230                 235                 240 


Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser Ile Leu Asp Leu 
                245                 250                 255     


Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr Val Arg Cys Thr 
            260                 265                 270         


Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met Ile Cys Lys Asp 
        275                 280                 285             


Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile Leu Ala Asn Asn 
    290                 295                 300                 


Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp Arg Ser Thr Val 
305                 310                 315                 320 


Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr Ile Ala Val Arg 
                325                 330                 335     


Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg Glu Leu Lys Leu 
            340                 345                 350         


Val Ala Pro Thr Leu Arg Ser Glu 
        355                 360 


<210>  6
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
1               5                   10                  15      


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
            20                  25                  30          


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
        35                  40                  45              


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
    50                  55                  60                  


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
65                  70                  75                  80  


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
                85                  90                  95      


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
            100                 105                 110         


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro 
        115                 120                 125     


<210>  7
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  7

Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His 
1               5                   10                  15      


Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly 
            20                  25                  30          


Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile 
        35                  40                  45              


Pro 
    


<210>  8
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Fc-sequence plus linker (Residues 1 to 6 of SEQ ID NO. 1)

<400>  8

Leu Thr Val Ala Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  9
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr 
1               5                   10                  15      


Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg 
            20                  25                  30          


His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu 
        35                  40                  45              


Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile 
    50                  55                  60                  


Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr Leu His Asn 
65                  70                  75                  80  


<210>  10
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  10

Ile Lys Val Pro Ser Ile Lys Leu Val Tyr Thr Leu Thr Val Pro Glu 
1               5                   10                  15      


Ala Thr Val Lys Asp Ser Gly Asp Tyr Glu Cys Ala Ala Arg Gln Ala 
            20                  25                  30          


Thr Arg Glu Val Lys Glu Met Lys 
        35                  40  


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  11

Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe Val 
1               5                   10                  15      


Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp 
            20                  25                  30  


<210>  12
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  12

Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe Val 
1               5                   10                  15      


Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp Ser 
            20                  25                  30          


Ala Ile Ile Pro Cys Arg Thr Thr 
        35                  40  


<210>  13
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  13

Asn Val Tyr Ala Leu Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu 
1               5                   10                  15      


Ala Leu Lys Thr Val Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys 
            20                  25                  30          


Ala Val Phe Asn Asn Glu Val Val 
        35                  40  


