                         SEQUENCE LISTING

<110>  ȫ޹˾
 
<120>  ͷ߾ǻøͻ塢ͻDNAʹøͻķӦ

<130>  UP-171668-59:52

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  957
<212>  DNA
<213>  ״ù(Streptomyces clavuligerus)

<400>  1
atggcagata ccccggtgcc gattttcaac ctggcagctc tgcgtgaagg tgccgaccaa       60

gaaaaatttc gcgaatgtgt gaccggcatg ggtgttttct atctgacggg ctacggtgca      120

ggcgataaag accaccgtct ggccaccgat acggcaatgg actttttcgc taatggtacc      180

gaagcggaaa aagcggccgt caccacggat gtgccgacga tgcgtcgcgg ctattctgct      240

ctggaagcgg aaagtaccgc ccaggttacc cgcaccggta gctatacgga ttacagtatg      300

tccttttcaa tgggcatttc cggtaacgtt tttccgtcac cggaattcga acgtgtctgg      360

accgaatatt tcgataaact gtacgcagct gcgcaagaaa ccgcacgtct ggttctgacg      420

gcatctggcg gttatgatgc tgaaatcgtc ggtagtctgg acgaactgct ggatgcggac      480

ccggttctgc gtctgcgcta ttttccggaa gttccggaac atcgttcggc agaacacgaa      540

ccgcgtcgta tggcaccgca ttacgatctg agcattatca cctttattca ccagacgccg      600

tgcgcaaatg gcttcgtctc cctgcaagct gaaatcggcg gtgaactggt gtcactgccg      660

gtggttgaag atgccgtcgt ggttatgtgt ggtgctatgg caccgctggc aacccagggt      720

gctctgccgg caccgcgtca tcacgtgcgc tcgccgggtg ccggtatgcg tgaaggtagc      780

gatcgcacca gctctgtttt ttttctgcgt ccgacgaccg acttttcgtt cagcgtggcc      840

aaagcacgca gctatggcct ggcagttgat ctggacatgg aaaccgcgac gtttggtgat      900

tggatcggca ccaactacgt tacgatgcat gcaaaaaatg aaccgcaggc gggctaa         957


<210>  2
<211>  318
<212>  PRT
<213>  ״ù(Streptomyces clavuligerus)

<400>  2

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr Gly Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Ala Gly Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Arg Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Thr 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  3
<211>  318
<212>  PRT
<213>  ˹

<400>  3

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr His Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Ala Gly Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Arg Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Thr 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  4
<211>  318
<212>  PRT
<213>  ˹

<400>  4

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr Gly Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Leu Gly Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Arg Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Thr 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  5
<211>  318
<212>  PRT
<213>  ˹

<400>  5

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr Gly Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Ala Thr Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Arg Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Thr 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  6
<211>  318
<212>  PRT
<213>  ˹

<400>  6

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr Gly Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Ala Gly Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Asp Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Thr 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  7
<211>  318
<212>  PRT
<213>  ˹

<400>  7

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr Gly Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Ala Gly Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Arg Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Arg 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  8
<211>  318
<212>  PRT
<213>  ˹

<400>  8

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr His Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Ala Thr Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Arg Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Thr 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  9
<211>  318
<212>  PRT
<213>  ˹

<400>  9

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr His Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Ala Thr Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Arg Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Arg 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  10
<211>  318
<212>  PRT
<213>  ˹

<400>  10

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr His Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Leu Thr Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Arg Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Arg 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  11
<211>  318
<212>  PRT
<213>  ˹

<400>  11

Met Ala Asp Thr Pro Val Pro Ile Phe Asn Leu Ala Ala Leu Arg Glu 
1               5                   10                  15      


Gly Ala Asp Gln Glu Lys Phe Arg Glu Cys Val Thr His Met Gly Val 
            20                  25                  30          


Phe Tyr Leu Thr Gly Tyr Gly Leu Thr Asp Lys Asp His Arg Leu Ala 
        35                  40                  45              


Thr Asp Thr Ala Met Asp Phe Phe Ala Asn Gly Thr Glu Ala Glu Lys 
    50                  55                  60                  


Ala Ala Val Thr Thr Asp Val Pro Thr Met Arg Arg Gly Tyr Ser Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Ser Thr Ala Gln Val Thr Arg Thr Gly Ser Tyr Thr 
                85                  90                  95      


Asp Tyr Ser Met Ser Phe Ser Met Gly Ile Ser Gly Asn Val Phe Pro 
            100                 105                 110         


Ser Pro Glu Phe Glu Arg Val Trp Thr Glu Tyr Phe Asp Lys Leu Tyr 
        115                 120                 125             


Ala Ala Ala Gln Glu Thr Ala Arg Leu Val Leu Thr Ala Ser Gly Gly 
    130                 135                 140                 


Tyr Asp Ala Glu Ile Val Gly Ser Leu Asp Glu Leu Leu Asp Ala Asp 
145                 150                 155                 160 


Pro Val Leu Arg Leu Arg Tyr Phe Pro Glu Val Pro Glu His Arg Ser 
                165                 170                 175     


Ala Glu His Glu Pro Asp Arg Met Ala Pro His Tyr Asp Leu Ser Ile 
            180                 185                 190         


Ile Thr Phe Ile His Gln Thr Pro Cys Ala Asn Gly Phe Val Ser Leu 
        195                 200                 205             


Gln Ala Glu Ile Gly Gly Glu Leu Val Ser Leu Pro Val Val Glu Asp 
    210                 215                 220                 


Ala Val Val Val Met Cys Gly Ala Met Ala Pro Leu Ala Thr Gln Gly 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Arg His His Val Arg Ser Pro Gly Ala Gly Met 
                245                 250                 255     


Arg Glu Gly Ser Asp Arg Thr Ser Ser Val Phe Phe Leu Arg Pro Arg 
            260                 265                 270         


Thr Asp Phe Ser Phe Ser Val Ala Lys Ala Arg Ser Tyr Gly Leu Ala 
        275                 280                 285             


Val Asp Leu Asp Met Glu Thr Ala Thr Phe Gly Asp Trp Ile Gly Thr 
    290                 295                 300                 


Asn Tyr Val Thr Met His Ala Lys Asn Glu Pro Gln Ala Gly 
305                 310                 315             


<210>  12
<211>  2852
<212>  DNA
<213>  ˹

<400>  12
gatctcgatc ccgcgaaatt aatacgactc actataggga gaccacaacg gtttccctct       60

agaaataatt ttgtttaact ttaagaagga gatatacata tgcggggttc tcatcatcat      120

catcatcatg gtatggctag catgactggt ggacagcaaa tgggtcggga tctgtacgac      180

gatgacgata aggatcgatg gggatccgag ctcgagatct gcagctggta ccatggaatt      240

cgaagcttga tccggctgct aacaaagccc gaaaggaagc tgagttggct gctgccaccg      300

ctgagcaata actagcataa ccccttgggg cctctaaacg ggtcttgagg ggttttttgc      360

tgaaaggagg aactatatcc ggatctggcg taatagcgaa gaggcccgca ccgatcgccc      420

ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg ccctgtagcg gcgcattaag      480

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc      540

cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc      600

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa      660

aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg      720

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac      780

actcaaccct atcgcggtct attcttttga tttataaggg attttgccga tttcggccta      840

ttggttaaaa aatgagctga tttaacaaat atttaacgcg aattttaaca aaatattaac      900

gcttacaatt taggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt      960

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     1020

taatattgaa aaaggaagag tatgagtcat attcaacggg aaacgtcttg ctctaggccg     1080

cgattaaatt ccaacatgga tgctgattta tatgggtata aatgggctcg cgataatgtc     1140

gggcaatcag gtgcgacaat ctatcgattg tatgggaagc ccgatgcgcc agagttgttt     1200

ctgaaacatg gcaaaggtag cgttgccaat gatgttacag atgagatggt cagactaaac     1260

tggctgacgg aatttatgcc tcttccgacc atcaagcatt ttatccgtac tcctgatgat     1320

gcatggttac tcaccactgc gatccccggg aaaacagcat tccaggtatt agaagaatat     1380

cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg gttgcattcg     1440

attcctgttt gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc tcaggcgcaa     1500

tcacgaatga ataacggttt ggttgatgcg agtgattttg atgacgagcg taatggctgg     1560

cctgttgaac aagtctggaa agaaatgcat aaacttttgc cattctcacc ggattcagtc     1620

gtcactcatg gtgatttctc acttgataac cttatttttg acgaggggaa attaataggt     1680

tgtattgatg ttggacgagt cggaatcgca gaccgatacc aggatcttgc catcctatgg     1740

aactgcctcg gtgagttttc tccttcatta cagaaacggc tttttcaaaa atatggtatt     1800

gataatcctg atatgaataa attgcagttt catttgatgc tcgatgagtt tttctaactg     1860

tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa     1920

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     1980

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     2040

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     2100

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     2160

ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta     2220

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     2280

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     2340

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     2400

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     2460

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     2520

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     2580

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     2640

cggttcctgg gcttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat     2700

tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg     2760

accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg caaaccgcct     2820

ctccccgcgc gttggccgat tcattaatgc ag                                   2852


