                         SEQUENCE LISTING

<110>  Health Research Inc.
 
<120>  PHARMACEUTICAL COMPOSITIONS WITH ANTIFLAVIVIRAL ACTIVITY

<130>  0332064AWO

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  179
<212>  PRT
<213>  Dengue virus type 2

<400>  1

Ala Gly Val Leu Trp Asp Val Pro Ser Pro Pro Pro Met Gly Lys Ala 
1               5                   10                  15      


Glu Leu Glu Asp Gly Ala Tyr Arg Ile Lys Gln Lys Gly Ile Leu Gly 
            20                  25                  30          


Tyr Ser Gln Ile Gly Ala Gly Val Tyr Lys Glu Gly Thr Phe His Thr 
        35                  40                  45              


Met Trp His Val Thr Arg Gly Ala Val Leu Met His Lys Gly Lys Arg 
    50                  55                  60                  


Ile Glu Pro Ser Trp Ala Asp Val Lys Lys Asp Leu Ile Ser Tyr Gly 
65                  70                  75                  80  


Gly Gly Trp Lys Leu Glu Gly Glu Trp Lys Glu Gly Glu Glu Val Gln 
                85                  90                  95      


Val Leu Ala Leu Glu Pro Gly Lys Asn Pro Arg Ala Val Gln Thr Lys 
            100                 105                 110         


Pro Gly Leu Phe Lys Thr Asn Ala Gly Thr Ile Gly Ala Val Ser Leu 
        115                 120                 125             


Asp Phe Ser Pro Gly Thr Ser Gly Ser Pro Ile Ile Asp Lys Lys Gly 
    130                 135                 140                 


Lys Val Val Gly Leu Tyr Gly Asn Gly Val Val Thr Arg Ser Gly Ala 
145                 150                 155                 160 


Tyr Val Ser Ala Ile Ala Gln Thr Glu Lys Ser Ile Glu Asp Asn Pro 
                165                 170                 175     


Glu Ile Glu 
            


<210>  2
<211>  180
<212>  PRT
<213>  Dengue virus type 1

<400>  2

Ser Gly Val Leu Trp Asp Thr Pro Ser Pro Pro Glu Val Glu Arg Ala 
1               5                   10                  15      


Val Leu Asp Asp Gly Ile Tyr Arg Ile Leu Gln Arg Gly Leu Leu Gly 
            20                  25                  30          


Arg Ser Gln Val Gly Val Gly Val Phe Gln Glu Gly Val Phe His Thr 
        35                  40                  45              


Met Trp His Val Thr Arg Gly Ala Val Leu Met Tyr Gln Gly Lys Arg 
    50                  55                  60                  


Leu Glu Pro Ser Trp Ala Ser Val Lys Lys Asp Leu Ile Ser Tyr Gly 
65                  70                  75                  80  


Gly Gly Trp Arg Phe Gln Gly Ser Trp Asn Ala Gly Glu Glu Val Gln 
                85                  90                  95      


Val Ile Ala Val Glu Pro Gly Lys Asn Pro Lys Asn Val Gln Thr Ala 
            100                 105                 110         


Pro Gly Thr Phe Lys Thr Pro Glu Gly Glu Val Gly Ala Ile Ala Leu 
        115                 120                 125             


Asp Phe Lys Pro Gly Thr Ser Gly Ser Pro Ile Val Asn Arg Glu Gly 
    130                 135                 140                 


Lys Ile Val Gly Leu Tyr Gly Asn Gly Val Val Thr Thr Ser Gly Thr 
145                 150                 155                 160 


Tyr Val Ser Ala Ile Ala Gln Ala Lys Ala Ser Gln Glu Gly Pro Leu 
                165                 170                 175     


Pro Glu Ile Glu 
            180 


<210>  3
<211>  180
<212>  PRT
<213>  Dengue virus type 3

<400>  3

Ser Gly Val Leu Trp Asp Val Pro Ser Pro Pro Glu Thr Gln Lys Ala 
1               5                   10                  15      


Glu Leu Glu Glu Gly Val Tyr Arg Ile Lys Gln Gln Gly Ile Phe Gly 
            20                  25                  30          


Lys Thr Gln Val Gly Val Gly Val Gln Lys Glu Gly Val Phe His Thr 
        35                  40                  45              


Met Trp His Val Thr Arg Gly Ala Val Leu Thr His Asn Gly Lys Arg 
    50                  55                  60                  


Leu Glu Pro Asn Trp Ala Ser Val Lys Lys Asp Leu Ile Ser Tyr Gly 
65                  70                  75                  80  


Gly Gly Trp Arg Leu Ser Ala Gln Trp Gln Lys Gly Glu Glu Val Gln 
                85                  90                  95      


Val Ile Ala Val Glu Pro Gly Lys Asn Pro Lys Asn Phe Gln Thr Thr 
            100                 105                 110         


Pro Gly Thr Phe Gln Thr Thr Thr Gly Glu Ile Gly Ala Ile Ala Leu 
        115                 120                 125             


Asp Phe Lys Pro Gly Thr Ser Gly Ser Pro Ile Ile Asn Arg Glu Gly 
    130                 135                 140                 


Lys Val Val Gly Leu Tyr Gly Asn Gly Val Val Thr Lys Asn Gly Gly 
145                 150                 155                 160 


Tyr Val Ser Gly Ile Ala Gln Thr Asn Ala Glu Pro Asp Gly Pro Thr 
                165                 170                 175     


Pro Glu Leu Glu 
            180 


<210>  4
<211>  179
<212>  PRT
<213>  Dengue virus type 4

<400>  4

Ser Gly Ala Leu Trp Asp Val Pro Ser Pro Ala Ala Thr Lys Lys Ala 
1               5                   10                  15      


Ala Leu Ser Glu Gly Val Tyr Arg Ile Met Gln Arg Gly Leu Phe Gly 
            20                  25                  30          


Lys Thr Gln Val Gly Val Gly Ile His Met Glu Gly Val Phe His Thr 
        35                  40                  45              


Met Trp His Val Thr Arg Gly Ser Val Ile Cys His Glu Thr Gly Arg 
    50                  55                  60                  


Leu Glu Pro Ser Trp Ala Asp Val Arg Asn Asp Met Ile Ser Tyr Gly 
65                  70                  75                  80  


Gly Gly Trp Arg Leu Gly Asp Lys Trp Asp Lys Glu Glu Asp Val Gln 
                85                  90                  95      


Val Leu Ala Ile Glu Pro Gly Lys Asn Pro Lys His Val Gln Thr Lys 
            100                 105                 110         


Pro Gly Leu Phe Lys Thr Leu Thr Gly Glu Ile Gly Ala Val Thr Leu 
        115                 120                 125             


Asp Phe Lys Pro Gly Thr Ser Gly Ser Pro Ile Ile Asn Arg Lys Gly 
    130                 135                 140                 


Lys Val Ile Gly Leu Tyr Gly Asn Gly Val Val Thr Lys Ser Gly Asp 
145                 150                 155                 160 


Tyr Val Ser Ala Ile Thr Gln Ala Glu Arg Ile Gly Glu Pro Asp Tyr 
                165                 170                 175     


Glu Val Asp 
            


<210>  5
<211>  180
<212>  PRT
<213>  West Nile virus

<400>  5

Gly Gly Val Leu Trp Asp Thr Pro Ser Pro Lys Glu Tyr Lys Lys Gly 
1               5                   10                  15      


Asp Thr Thr Thr Gly Val Tyr Arg Ile Met Thr Arg Gly Leu Leu Gly 
            20                  25                  30          


Ser Tyr Gln Ala Gly Ala Gly Val Met Val Glu Gly Val Phe His Thr 
        35                  40                  45              


Leu Trp His Thr Thr Lys Gly Ala Ala Leu Met Ser Gly Glu Gly Arg 
    50                  55                  60                  


Leu Asp Pro Tyr Trp Gly Ser Val Lys Glu Asp Arg Leu Cys Tyr Gly 
65                  70                  75                  80  


Gly Pro Trp Lys Leu Gln His Lys Trp Asn Gly Gln Asp Glu Val Gln 
                85                  90                  95      


Met Ile Val Val Glu Pro Gly Lys Asn Val Lys Asn Val Gln Thr Lys 
            100                 105                 110         


Pro Gly Val Phe Lys Thr Pro Glu Gly Glu Ile Gly Ala Val Thr Leu 
        115                 120                 125             


Asp Phe Pro Thr Gly Thr Ser Gly Ser Pro Ile Val Asp Lys Asn Gly 
    130                 135                 140                 


Asp Val Ile Gly Leu Tyr Gly Asn Gly Val Ile Met Pro Asn Gly Ser 
145                 150                 155                 160 


Tyr Ile Ser Ala Ile Val Gln Gly Glu Arg Met Asp Glu Pro Ile Pro 
                165                 170                 175     


Ala Gly Phe Glu 
            180 


<210>  6
<211>  180
<212>  PRT
<213>  Japanese encephalitis virus

<400>  6

Gly Gly Val Phe Trp Asp Thr Pro Ser Pro Lys Pro Cys Ser Lys Gly 
1               5                   10                  15      


Asp Thr Thr Thr Gly Val Tyr Arg Ile Met Ala Arg Gly Ile Leu Gly 
            20                  25                  30          


Thr Tyr Gln Ala Gly Val Gly Val Met Tyr Glu Asn Val Phe His Thr 
        35                  40                  45              


Leu Trp His Thr Thr Arg Gly Ala Ala Ile Met Ser Gly Glu Gly Lys 
    50                  55                  60                  


Leu Thr Pro Tyr Trp Gly Ser Val Lys Glu Asp Arg Ile Ala Tyr Gly 
65                  70                  75                  80  


Gly Pro Trp Arg Phe Asp Arg Lys Trp Asn Gly Thr Asp Asp Val Gln 
                85                  90                  95      


Val Ile Val Val Glu Pro Gly Lys Ala Ala Val Asn Ile Gln Thr Lys 
            100                 105                 110         


Pro Gly Val Phe Arg Thr Pro Phe Gly Glu Val Gly Ala Val Ser Leu 
        115                 120                 125             


Asp Tyr Pro Arg Gly Thr Ser Gly Ser Pro Ile Leu Asp Ser Asn Gly 
    130                 135                 140                 


Asp Ile Ile Gly Leu Tyr Gly Asn Gly Val Glu Leu Gly Asp Gly Ser 
145                 150                 155                 160 


Tyr Val Ser Ala Ile Val Gln Gly Asp Arg Gln Glu Glu Pro Val Pro 
                165                 170                 175     


Glu Ala Tyr Thr 
            180 


<210>  7
<211>  180
<212>  PRT
<213>  St. Louis encephalitis virus

<400>  7

Gly Gly Ala Leu Trp Asp Val Pro Ser Pro Lys Val Tyr Pro Lys Cys 
1               5                   10                  15      


Glu Thr Lys Pro Gly Ile Tyr Arg Ile Met Thr Arg Gly Ile Leu Gly 
            20                  25                  30          


Thr Phe Gln Ala Gly Val Gly Val Met His Glu Gly Val Phe His Thr 
        35                  40                  45              


Met Trp His Ala Thr Glu Gly Ala Val Leu Arg Asn Gly Glu Gly Arg 
    50                  55                  60                  


Leu Asp Pro Tyr Ala Gly Asp Val Arg Asn Asp Leu Ile Ser Tyr Gly 
65                  70                  75                  80  


Gly Pro Trp Lys Leu Ser Ala Thr Trp Asp Gly Thr Glu Glu Val Gln 
                85                  90                  95      


Met Ile Ala Val Ala Pro Gly Lys Pro Ala Ile Asn Val Gln Thr Thr 
            100                 105                 110         


Pro Gly Val Phe Lys Thr Pro Leu Gly Thr Ile Gly Ala Val Thr Leu 
        115                 120                 125             


Asp Phe Pro Lys Gly Thr Ser Gly Ser Pro Ile Ile Asn Lys Lys Gly 
    130                 135                 140                 


Glu Ile Ile Gly Leu Tyr Gly Asn Gly Val Leu Ile Gly Gln Gly Glu 
145                 150                 155                 160 


Tyr Val Ser Gly Ile Ile Gln Gly Glu Arg Thr Glu Glu Pro Ile Pro 
                165                 170                 175     


Asp Ala Tyr Asn 
            180 


<210>  8
<211>  180
<212>  PRT
<213>  Zika virus

<400>  8

Ser Gly Ala Leu Trp Asp Val Pro Ala Pro Lys Glu Val Lys Lys Gly 
1               5                   10                  15      


Glu Thr Thr Asp Gly Val Tyr Arg Val Met Thr Arg Arg Leu Leu Gly 
            20                  25                  30          


Ser Thr Gln Val Gly Val Gly Val Met Gln Glu Gly Val Phe His Thr 
        35                  40                  45              


Met Trp His Val Thr Lys Gly Ala Ala Leu Arg Ser Gly Glu Gly Arg 
    50                  55                  60                  


Leu Asp Pro Tyr Trp Gly Asp Val Lys Gln Asp Leu Val Ser Tyr Cys 
65                  70                  75                  80  


Gly Pro Trp Lys Leu Asp Ala Ala Trp Asp Gly Leu Ser Glu Val Gln 
                85                  90                  95      


Leu Leu Ala Val Pro Pro Gly Glu Arg Ala Arg Asn Ile Gln Thr Leu 
            100                 105                 110         


Pro Gly Ile Phe Lys Thr Lys Asp Gly Asp Ile Gly Ala Val Ala Leu 
        115                 120                 125             


Asp Tyr Pro Ala Gly Thr Ser Gly Ser Pro Ile Leu Asp Lys Cys Gly 
    130                 135                 140                 


Arg Val Ile Gly Leu Tyr Gly Asn Gly Val Val Ile Lys Asn Gly Ser 
145                 150                 155                 160 


Tyr Val Ser Ala Ile Thr Gln Gly Lys Arg Glu Glu Glu Thr Pro Val 
                165                 170                 175     


Glu Cys Phe Glu 
            180 


<210>  9
<211>  183
<212>  PRT
<213>  Yellow fever virus

<400>  9

Ser Gly Asp Val Leu Trp Asp Ile Pro Thr Pro Lys Ile Ile Glu Glu 
1               5                   10                  15      


Cys Glu His Leu Glu Asp Gly Ile Tyr Gly Ile Phe Gln Ser Thr Phe 
            20                  25                  30          


Leu Gly Ala Ser Gln Arg Gly Val Gly Val Ala Gln Gly Gly Val Phe 
        35                  40                  45              


His Thr Met Trp His Val Thr Arg Gly Ala Phe Leu Val Arg Asn Gly 
    50                  55                  60                  


Lys Lys Leu Ile Pro Ser Trp Ala Ser Val Lys Glu Asp Leu Val Ala 
65                  70                  75                  80  


Tyr Gly Gly Ser Trp Lys Leu Glu Gly Arg Trp Asp Gly Glu Glu Glu 
                85                  90                  95      


Val Gln Leu Ile Ala Ala Val Pro Gly Lys Asn Val Val Asn Val Gln 
            100                 105                 110         


Thr Lys Pro Ser Leu Phe Lys Val Arg Asn Gly Gly Glu Ile Gly Ala 
        115                 120                 125             


Val Ala Leu Asp Tyr Pro Ser Gly Thr Ser Gly Ser Pro Ile Val Asn 
    130                 135                 140                 


Arg Asn Gly Glu Val Ile Gly Leu Tyr Gly Asn Gly Ile Leu Val Gly 
145                 150                 155                 160 


Asp Asn Ser Phe Val Ser Ala Ile Ser Gln Thr Glu Val Lys Glu Glu 
                165                 170                 175     


Gly Lys Glu Glu Leu Gln Glu 
            180             


<210>  10
<211>  182
<212>  PRT
<213>  Tick-borne encephalitis virus

<400>  10

Ser Asp Leu Val Phe Ser Gly Gln Gly Gly Arg Glu Arg Gly Asp Arg 
1               5                   10                  15      


Pro Phe Glu Val Lys Asp Gly Val Tyr Arg Ile Phe Ser Pro Gly Leu 
            20                  25                  30          


Phe Trp Gly Gln Asn Gln Val Gly Val Gly Tyr Gly Ser Lys Gly Val 
        35                  40                  45              


Leu His Thr Met Trp His Val Thr Arg Gly Ala Ala Leu Ser Ile Asp 
    50                  55                  60                  


Asp Ala Val Ala Gly Pro Tyr Trp Ala Asp Val Arg Glu Asp Val Val 
65                  70                  75                  80  


Cys Tyr Gly Gly Ala Trp Ser Leu Glu Glu Lys Trp Lys Gly Glu Thr 
                85                  90                  95      


Val Gln Val His Ala Phe Pro Pro Gly Arg Ala His Glu Val His Gln 
            100                 105                 110         


Cys Gln Pro Gly Glu Leu Ile Leu Asp Thr Gly Arg Lys Leu Gly Ala 
        115                 120                 125             


Ile Pro Ile Asp Leu Val Lys Gly Thr Ser Gly Ser Pro Ile Leu Asn 
    130                 135                 140                 


Ala Gln Gly Val Val Val Gly Leu Tyr Gly Asn Gly Leu Lys Thr Asn 
145                 150                 155                 160 


Glu Thr Tyr Val Ser Ser Ile Ala Gln Gly Glu Ala Glu Lys Ser Arg 
                165                 170                 175     


Pro Asn Leu Pro Gln Ala 
            180         


<210>  11
<211>  182
<212>  PRT
<213>  Powassan virus

<400>  11

Thr Asp Leu Val Phe Ser Gly Gln Leu Pro Asp Gln Gly Glu Lys Arg 
1               5                   10                  15      


Ser Phe Asp Ile Lys Glu Gly Val Tyr Arg Ile Tyr Ala Pro Gly Leu 
            20                  25                  30          


Phe Trp Gly Tyr Arg Gln Ile Gly Val Gly Tyr Gly Thr Lys Gly Val 
        35                  40                  45              


Leu His Thr Met Trp His Val Thr Arg Gly Ala Ala Leu Ser Val Glu 
    50                  55                  60                  


Gly Ala Thr Ser Gly Pro Tyr Trp Ala Asp Val Arg Glu Asp Val Val 
65                  70                  75                  80  


Cys Tyr Gly Gly Ala Trp Gly Leu Asp Lys Lys Trp Gly Gly Glu Val 
                85                  90                  95      


Val Gln Val His Ala Phe Pro Pro Asp Ser Gly His Lys Ile His Gln 
            100                 105                 110         


Cys Gln Pro Gly Lys Leu Asn Leu Glu Gly Gly Arg Val Leu Gly Ala 
        115                 120                 125             


Ile Pro Ile Asp Leu Pro Arg Gly Thr Ser Gly Ser Pro Ile Ile Asn 
    130                 135                 140                 


Ala Gln Gly Asp Val Leu Gly Leu Tyr Gly Asn Gly Leu Lys Ser Asn 
145                 150                 155                 160 


Asp Val Tyr Ile Ser Ser Ile Ala Gln Gly Asn Val Glu Lys Ser Arg 
                165                 170                 175     


Pro Glu Met Pro Leu Ala 
            180         


<210>  12
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory-synthesized sequence

<400>  12
cagactaatg ccggatccca tatggctgga gtattgtggg atgtc                       45


<210>  13
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  13
gtcgtgaaac agtacgtgat cttaagggtc actttcgaaa aatatcatct tcgatctctg       60


<210>  14
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  14
gatataccat gggcagcagc catcatcatc atcatcacga agacgccaaa aacataaag        59


<210>  15
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  15
ccatatggct agcgctggag tattgtggga tgtcc                                  35


<210>  16
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  16
gctcgaattc ggatccctat ccctttcgaa aaatatcatc ttc                         43


<210>  17
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  17
cggcgctagc catatggctg ccgcgcggca ccaggccgct tccatccttg tcaatcaagg       60


<210>  18
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  18
gtcaaatggg aagatcaggc ataaatatca ggaagcagtc caatc                       45


<210>  19
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  19
gattggactg cttcctgata tttatgcctg atcttcccat ttgac                       45


<210>  20
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  20
ggtggtagcg gcggcggtgg ggaagacgcc aaaaacataa ag                          42


<210>  21
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  21
gtcgacggag ctcgaattct catccatcct tgtcaatcaa ggcg                        44


<210>  22
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  22
cgccgatgtc aaatgggaag gcggtggtag cggtggtgaa gacgccaaaa acataaag         58


<210>  23
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  23
gtcgacggag ctcgaattct catccatcct tgtcaatcaa ggcg                        44


<210>  24
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  24
gttctgttcc agggtccact gggatcctcc ggttatgtaa acaatccgga ag               52


<210>  25
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  25
gggacatccc acaatactcc agccacggcg atctttccgc ccttc                       45


<210>  26
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  26
gaagggcgga aagatcgccg tggctggagt attgtgggat gtccc                       45


<210>  27
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  27
gtcacgatgc ggccgctcga gtcactttcg aaaaatatca tcttcgatct                  50


<210>  28
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  28
caatccagag atcgaagatg atattttttc cggttatgta aacaatccgg                  50


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Laboratory synthesized sequence

<400>  29
ccgggagctg catgtgtcag agg                                               23


