                         SEQUENCE LISTING

<110>  Commissariat  l'Energie Atomique et aux Energies 
       Alternatives
 
<120>  Antibody directed against the endothelin receptor sub-type B and 
       uses thereof

<130>  S60677 PCT SG-T

<140>  PCT/EPXX/XXXXX
<141>  2017-06-22

<150>  FR 1655915
<151>  2016-06-24

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  PRT
<213>  Unknown

<220>
<223>  Ordered juxtaposition of the CDRs of the heavy chain variable 
       region

<400>  1

Gly Tyr Thr Phe Ile Ser Tyr Trp Ile Asp Pro Asp Ser Gly Gly Thr 
1               5                   10                  15      


Ala Arg Glu Gly Asp Tyr Ala Trp Phe Ala Tyr 
            20                  25          


<210>  2
<211>  23
<212>  PRT
<213>  Unknown

<220>
<223>  Ordered juxtaposition of the CDRs of the light chain variable 
       region

<400>  2

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Lys Val Ser Phe Gln 
1               5                   10                  15      


Gly Ser His Val Pro Trp Thr 
            20              


<210>  3
<211>  8
<212>  PRT
<213>  unknown

<220>
<223>  Consensus sequence for CDR1H


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X represents any amino acid and, in particular, either I, or T

<400>  3

Gly Tyr Thr Phe Xaa Ser Tyr Trp 
1               5               


<210>  4
<211>  24
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(24)
<223>  CDR1H of Rendomab B49

<400>  4
ggc tac acc ttc atc agc tac tgg                                         24
Gly Tyr Thr Phe Ile Ser Tyr Trp                                           
1               5                                                         


<210>  5
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  5

Gly Tyr Thr Phe Ile Ser Tyr Trp 
1               5               


<210>  6
<211>  24
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(24)
<223>  CDR1H of Rendomab B41 and Rendomab B36

<400>  6
ggc tac acc ttc acc agc tac tgg                                         24
Gly Tyr Thr Phe Thr Ser Tyr Trp                                           
1               5                                                         


<210>  7
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Consensus sequence for CDR2H


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X represents any amino acid and, in particular, either D, or N

<400>  8

Ile Asp Pro Xaa Ser Gly Gly Thr 
1               5               


<210>  9
<211>  24
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  Sequence coding CDR2H of Rendomab B49 (N = C) or of Rendomab B41 
       (N = T)

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  N represents either C, or T

<400>  9
attgatcctg atagnggtgg tact                                              24


<210>  10
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  DOMAIN
<222>  (1)..(8)
<223>  CDR2H of Rendomab B49 and of Rendomab B41

<400>  10

Ile Asp Pro Asp Ser Gly Gly Thr 
1               5               


<210>  11
<211>  24
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(24)
<223>  CDR2H of Rendomab B36

<400>  11
att gat cct aat agt ggt ggc act                                         24
Ile Asp Pro Asn Ser Gly Gly Thr                                           
1               5                                                         


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Ile Asp Pro Asn Ser Gly Gly Thr 
1               5               


<210>  13
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Consensus sequence for CDR3H


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents any amino acid and, in particular, is selected from 
       A, D, Y, E, F, V and W and, more particularly, it is either A, or
       V

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X represents any amino acid and, in particular, is selected from 
       A, D, Y, E, F, V and W and, more particularly, is selected from 
       D, W and E

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents any amino acid and, in particular, is selected from 
       A, D, Y, E, F, V and W and, more particularly, is selected from 
       Y, D and F

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents any amino acid and, in particular, is selected from 
       A, D, Y, E, F, V and W and, more particularly, is either A, or V

<400>  13

Xaa Arg Glu Gly Xaa Xaa Ala Trp Phe Xaa Tyr 
1               5                   10      


<210>  14
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(33)
<223>  CDR3H of Rendomab B49

<400>  14
gca aga gaa ggg gat tac gcc tgg ttt gct tac                             33
Ala Arg Glu Gly Asp Tyr Ala Trp Phe Ala Tyr                               
1               5                   10                                    


<210>  15
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  15

Ala Arg Glu Gly Asp Tyr Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  16
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(33)
<223>  CDR3H of Rendomab B41

<400>  16
gta aga gaa ggg tgg gac gcc tgg ttt gtt tac                             33
Val Arg Glu Gly Trp Asp Ala Trp Phe Val Tyr                               
1               5                   10                                    


<210>  17
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  17

Val Arg Glu Gly Trp Asp Ala Trp Phe Val Tyr 
1               5                   10      


<210>  18
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(33)
<223>  CDR3H of Rendomab B36

<400>  18
gca aga gag ggg gaa ttc gcc tgg ttt gct tac                             33
Ala Arg Glu Gly Glu Phe Ala Trp Phe Ala Tyr                               
1               5                   10                                    


<210>  19
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  19

Ala Arg Glu Gly Glu Phe Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Consensus sequence for CDR1L


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents any amino acid and, in particular, is selected from 
       N, Y and S and, more particularly, is either N, or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X represents any amino acid and, in particular, is selected from 
       N, Y and S and, more particularly, is either N, or Y

<400>  20

Gln Xaa Ile Val His Ser Asn Gly Xaa Thr Tyr 
1               5                   10      


<210>  21
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(33)
<223>  CDR1L of Rendomab B49 and of Rendomab B41

<400>  21
cag agc att gta cat agt aat gga aac acc tat                             33
Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr                               
1               5                   10                                    


<210>  22
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  22

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  23
<211>  33
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(33)
<223>  CDR1L of Rendomab B36

<400>  23
cag aac att gtc cat agt aat gga tac acc tat                             33
Gln Asn Ile Val His Ser Asn Gly Tyr Thr Tyr                               
1               5                   10                                    


<210>  24
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  24

Gln Asn Ile Val His Ser Asn Gly Tyr Thr Tyr 
1               5                   10      


<210>  25
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Consensus sequence for CDR3L


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X represents any amino acid and, in particular, is either W, or L

<400>  25

Phe Gln Gly Ser His Val Pro Xaa Thr 
1               5                   


<210>  26
<211>  27
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(27)
<223>  CDR3L of Rendomab B49

<400>  26
ttt caa ggt tca cat gtt ccg tgg acg                                     27
Phe Gln Gly Ser His Val Pro Trp Thr                                       
1               5                                                         


<210>  27
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  27

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  28
<211>  27
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  Sequence coding CDR3L of Rendomab B41 and of Rendomab B36

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  N represents either G, or T

<400>  28
tttcaaggtt cacatgttcc nctcacg                                           27


<210>  29
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  DOMAIN
<222>  (1)..(9)
<223>  CDR3L of Rendomab B41 and of Rendomab B36

<400>  29

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  30
<211>  354
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(354)
<223>  Heavy chain variable region of Rendomab B49

<400>  30
cag gtc caa ctg cag cag cct ggg gct gcg ctt gtg aag cct ggg gct         48
Gln Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag ctg tcc tgc aag gct tct ggc tac acc ttc atc agc tac         96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr           
            20                  25                  30                    

tgg atg ctc tgg gtg aag cag agg cct gga cga ggc ctt gag tgg att        144
Trp Met Leu Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga agg att gat cct gat agc ggt ggt act aag tac aat gag aag ttc        192
Gly Arg Ile Asp Pro Asp Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aag agc aag gcc aca ctg act gta gac aaa tcc tcc agc aca gcc tac        240
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg cag ctc agc agc ctg aca tct gag gac tct gcg gtc tat tat tgt        288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga gaa ggg gat tac gcc tgg ttt gct tac tgg ggc caa ggg act        336
Ala Arg Glu Gly Asp Tyr Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc cct gtc tct gca                                                354
Leu Val Pro Val Ser Ala                                                   
        115                                                               


<210>  31
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  31

Gln Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          


Trp Met Leu Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Asp Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asp Tyr Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Pro Val Ser Ala 
        115             


<210>  32
<211>  354
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(354)
<223>  Heavy chain variable region of Rendomab B41

<400>  32
cag gtc caa ctg cag cag cct ggg gct gag ctt gtg aag cct ggg gct         48
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag ctg tcc tgc aag gct tct ggc tac acc ttc acc agc tac         96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

tgg atg cac tgg gtg aag cag agg cct gga cga ggc ctt gag tgg att        144
Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga agg att gat cct gat agt ggt ggt act aaa tac aat gag aag ttc        192
Gly Arg Ile Asp Pro Asp Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aag agc aag gcc aca ctg act gta gac aaa ccc tcc aac aca gcc aac        240
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Asn Thr Ala Asn           
65                  70                  75                  80            

atg cag ctc agc agc ctg aca tct gaa gac tct gcg gtc tat tat tgt        288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

gta aga gaa ggg tgg gac gcc tgg ttt gtt tac tgg ggc caa ggg act        336
Val Arg Glu Gly Trp Asp Ala Trp Phe Val Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg ctc act gtc tct gca                                                354
Leu Leu Thr Val Ser Ala                                                   
        115                                                               


<210>  33
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  33

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Asp Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Asn Thr Ala Asn 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Gly Trp Asp Ala Trp Phe Val Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Leu Thr Val Ser Ala 
        115             


<210>  34
<211>  354
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(354)
<223>  Heavy chain variable region of Rendomab B36

<400>  34
cag gtc caa ctg cag cag cct ggg gct gaa ctt gtg aag cct ggg gct         48
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag ctg tcc tgc aag gct tct ggc tac acc ttc acc agc tac         96
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

tgg ata cac tgg gta aat cag agg cct gga cga ggc ctt gag tgg att        144
Trp Ile His Trp Val Asn Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga agg att gat cct aat agt ggt ggc act aag tac aat gag aag ttc        192
Gly Arg Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aag agt aag gcc aca ctg act gta gac aaa acc tcc agc aca gcc tac        240
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Thr Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg cag ttc agc agc ctg aca tct gag gac tct gcg gtc tat tat tgt        288
Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga gag ggg gaa ttc gcc tgg ttt gct tac tgg ggc caa ggg act        336
Ala Arg Glu Gly Glu Phe Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc act gtc tct gca                                                354
Leu Val Thr Val Ser Ala                                                   
        115                                                               


<210>  35
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  35

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Asn Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Thr Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Glu Phe Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  36
<211>  336
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(336)
<223>  Light chain variable region of Rendomab B49

<400>  36
gat gtt ttg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga         48
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gat caa gcc tcc atc tct tgc aga tct agt cag agc att gta cat agt         96
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser           
            20                  25                  30                    

aat gga aac acc tat tta gaa tgg tac ctg cag aaa cca ggc cag tct        144
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca aag ctc ctg atc tac aaa gtt tcc aac cga ttt tct ggg gtc cca        192
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggg aca gat ttc aca ctc aag atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat ctg gga gtt tat tac tgc ttt caa ggt        288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly           
                85                  90                  95                

tca cat gtt ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa        336
Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   


<210>  37
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  37

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  38
<211>  339
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(339)
<223>  Light chain variable region of Rendomab B41

<400>  38
gat gtt ttg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga         48
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gat caa gcc tcc atc tct tgc aga tct agt cag agc att gta cat agt         96
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser           
            20                  25                  30                    

aat gga aac acc tat tta gaa tgg tac ttg cag aaa cca ggc cag tct        144
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca aag ctc ctg atc tac aaa gtt ttc aac cga ttt tct ggg gtc cca        192
Pro Lys Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggg aca gat ttc aca ctc aag atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat ctg gga gtt tat tac tgc ttt caa ggt        288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly           
                85                  90                  95                

tca cat gtt ccg ctc acg ttc ggt gct ggg acc aag ctg gag ctg aaa        336
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys           
            100                 105                 110                   

cgg                                                                    339
Arg                                                                       
                                                                          


<210>  39
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  39

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Phe Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  40
<211>  339
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(339)
<223>  Light chain variable region of Rendomab B36

<400>  40
gat gtt ttg atg acc caa act cca ctc tcc ctg cct gtc agt ctt gga         48
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gat caa gcc tcc atc tct tgc aga tct agt cag aac att gtc cat agt         96
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser           
            20                  25                  30                    

aat gga tac acc tat tta gaa tgg tac ctg cag aaa cca ggc cag tct        144
Asn Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca aag ctc ctg atc tac aaa gtt tcc aac cga ttt tct ggg gtc cca        192
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggg aca gat ttc aca ctc aag atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat ctg gga gtt tat tac tgc ttt caa ggt        288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly           
                85                  90                  95                

tca cat gtt cct ctc acg ttc ggc tcg ggg aca aag ttg gaa ata aaa        336
Ser His Val Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   

cgg                                                                    339
Arg                                                                       
                                                                          


<210>  41
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  41

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Tyr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  42
<211>  442
<212>  PRT
<213>  Homo sapiens


<220>
<221>  CHAIN
<222>  (1)..(442)
<223>  Sequence of the human endothelin receptor sub-type B

<220>
<221>  CHAIN
<222>  (1)..(101)
<223>  Extracellular region

<220>
<221>  SIGNAL
<222>  (1)..(26)
<223>  Signal peptide

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Proteolysis site

<220>
<221>  CHAIN
<222>  (65)..(76)
<223>  Peptide C5

<220>
<221>  CHAIN
<222>  (66)..(77)
<223>  Peptide C6

<220>
<221>  CHAIN
<222>  (67)..(78)
<223>  Peptide C7

<220>
<221>  CHAIN
<222>  (68)..(79)
<223>  Peptide C8

<220>
<221>  CHAIN
<222>  (69)..(80)
<223>  Peptide C9

<220>
<221>  CHAIN
<222>  (70)..(81)
<223>  Peptide C10

<220>
<221>  CHAIN
<222>  (70)..(76)
<223>  Epitope recognized by Rendomab-B49

<220>
<221>  CHAIN
<222>  (71)..(82)
<223>  Peptide C11

<220>
<221>  CHAIN
<222>  (72)..(83)
<223>  Peptide C12

<220>
<221>  CHAIN
<222>  (102)..(126)
<223>  Transmembrane region

<220>
<221>  CHAIN
<222>  (127)..(137)
<223>  Intracellular region

<220>
<221>  CHAIN
<222>  (138)..(163)
<223>  Transmembrane region

<220>
<221>  CHAIN
<222>  (164)..(175)
<223>  Extracellular region

<220>
<221>  CHAIN
<222>  (176)..(197)
<223>  Transmembrane region

<220>
<221>  CHAIN
<222>  (198)..(218)
<223>  Intracellular region

<220>
<221>  CHAIN
<222>  (219)..(243)
<223>  Transmembrane region

<220>
<221>  CHAIN
<222>  (244)..(274)
<223>  Extracellular region

<220>
<221>  CHAIN
<222>  (275)..(296)
<223>  Transmembrane region

<220>
<221>  CHAIN
<222>  (297)..(324)
<223>  Intracellular region

<220>
<221>  CHAIN
<222>  (325)..(350)
<223>  Transmembrane region

<220>
<221>  CHAIN
<222>  (351)..(362)
<223>  Extracellular region

<220>
<221>  CHAIN
<222>  (363)..(389)
<223>  Transmembrane region

<220>
<221>  CHAIN
<222>  (390)..(442)
<223>  Intracellular region

<400>  42

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


