                         SEQUENCE LISTING

<110>  Bergen Teknologioverforing AS
       Bergenbio AS
 
<120>  ANTI-AXL ANTAGONISTIC ANTIBODIES

<130>  RKA/LP7288178

<150>  GB1610902.7
<151>  2016-06-22

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu10G5 VH(GH1)

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Ala Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Asp Phe 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  2
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu10G5 VH(GH2)

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Asp Phe 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Ala Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu10G5 VL(GL1)

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Pro Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Gly 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hu10G5 VL(GL2)

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Pro Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Gly 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example heavy chain constant region

<400>  5

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  6
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 GH1 Heavy chain

<400>  6

Glu Val Gln Leu Val Gln Ser Gly Ala Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Asp Phe 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  7
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 GH2 Heavy chain

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Asp Phe 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Ala Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  example light chain constant region

<400>  8

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  9
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 GL1 Light chain

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Pro Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Gly 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  10
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 GL2 Light chain

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Pro Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Gly 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  11
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu10G5 VH(GH1) nucleic acid

<400>  11
gaggtgcagc tggtccagtc cggagctgga ctggtgcagc caggcggatc tgtcagactg       60

agttgcgccg cttccggcta cagcttcacc gacttttata tcaactgggt cagacaggcc      120

cccggcaagg gtctggagtg gatcgctcgc attttccctg ggggtgacaa cacatactac      180

aacgaaaagt tcaaaggcag gttcaccctg tccgccgata cttccagctc taccgcatac      240

ctgcaactga actccctgag ggcagaagac acagccgtgt actattgtgc caggcggggc      300

ctgtactatg ctatggatta ttggggccag ggaaccctgg tgacagtctc gagc            354


<210>  12
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu10G5 VH(GH2) nucleic acid

<400>  12
gaggtgcagc tggtggaatc cggcggaggg ctggtgcagc caggtggcag cctgagactg       60

tcttgcgccg cttcaggata ctccttcacc gacttttata tcaactgggt cagacaggcc      120

cccggcaagg gcctggagtg ggtcgctcgc attttccctg gaggggacaa cacatactac      180

aacgaaaagt tcaaaggcag gttcaccctg agtgctgata cttctaaaag taccgcatac      240

ctgcaaatga atagcctgag ggcagaggac acagccgtgt actattgtgc caggcggggc      300

ctgtactatg ctatggatta ttggggacag gggaccctgg tgacagtctc gagc            354


<210>  13
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu10G5 VL(GL1) nucleic acid

<400>  13
gacatccaga tgacacagtc tccctccagc ctgagcgcct ctgtgggaga tagagtcacc       60

atcacatgca ggtctagtca gagcctggtg cactctaacg gcatccccta cctgcattgg      120

tatcagcaga agccagggaa agctcccaag ctgctgatct acagagtcag taatcggttc      180

tctggtgtcc cttcgaggtt tagtggctca ggctccggga cagacttcac tctgaccatt      240

tcatccctgc aaccagagga ttttgcaact tactattgta gccagggcac acacgtgccc      300

cctactttcg gtcagggcac caaagtcgaa attaag                                336


<210>  14
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu10G5 VL(GL2) nucleic acid

<400>  14
gacatccaga tgacacagtc tccctccagc ctgagcgcct ctgtgggcga tcgagtcacc       60

atcacatgca ggtctagtca gagcctggtg cactctaacg gcattcctta cctgcattgg      120

tatcagcaga agccaggaaa agctcccaag ctgctgatct acagagtcag taatcggttc      180

tctggcgtgc cctccaggtt ctccgggtca cgctccggaa cagacttcac tctgaccatt      240

tcatccctgc aaccagagga ttttgcaact tactattgta gccagggaac acacgtgccc      300

cctactttcg gccagggaac caaagtcgaa attaag                                336


<210>  15
<211>  990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example heavy chain constant region nucleic acid

<400>  15
gctagcacaa agggccctag tgtgtttcct ctggctccct cttccaaatc cacttctggt       60

ggcactgctg ctctgggatg cctggtgaag gattactttc ctgaacctgt gactgtctca      120

tggaactctg gtgctctgac ttctggtgtc cacactttcc ctgctgtgct gcagtctagt      180

ggactgtact ctctgtcatc tgtggtcact gtgccctctt catctctggg aacccagacc      240

tacatttgta atgtgaacca caaaccatcc aacactaaag tggacaaaaa agtggaaccc      300

aaatcctgtg acaaaaccca cacctgccca ccttgtcctg cccctgaact gctgggagga      360

ccttctgtgt ttctgttccc ccccaaacca aaggataccc tgatgatctc tagaacccct      420

gaggtgacat gtgtggtggt ggatgtgtct catgaggacc ctgaggtcaa attcaactgg      480

tacgtggatg gagtggaagt ccacaatgcc aaaaccaagc ctagagagga acagtacaat      540

tcaacctaca gagtggtcag tgtgctgact gtgctgcatc aggattggct gaatggcaag      600

gaatacaagt gtaaagtctc aaacaaggcc ctgcctgctc caattgagaa aacaatctca      660

aaggccaagg gacagcctag ggaaccccag gtctacaccc tgccaccttc aagagaggaa      720

atgaccaaaa accaggtgtc cctgacatgc ctggtcaaag gcttctaccc ttctgacatt      780

gctgtggagt gggagtcaaa tggacagcct gagaacaact acaaaacaac cccccctgtg      840

ctggattctg atggctcttt ctttctgtac tccaaactga ctgtggacaa gtctagatgg      900

cagcagggga atgtcttttc ttgctctgtc atgcatgagg ctctgcataa ccactacact      960

cagaaatccc tgtctctgtc tcccgggaaa                                       990


<210>  16
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10G5 GH1 Heavy chain nucleic acid

<400>  16
gaggtgcagc tggtccagtc cggagctgga ctggtgcagc caggcggatc tgtcagactg       60

agttgcgccg cttccggcta cagcttcacc gacttttata tcaactgggt cagacaggcc      120

cccggcaagg gtctggagtg gatcgctcgc attttccctg ggggtgacaa cacatactac      180

aacgaaaagt tcaaaggcag gttcaccctg tccgccgata cttccagctc taccgcatac      240

ctgcaactga actccctgag ggcagaagac acagccgtgt actattgtgc caggcggggc      300

ctgtactatg ctatggatta ttggggccag ggaaccctgg tgacagtctc gagcgctagc      360

acaaagggcc ctagtgtgtt tcctctggct ccctcttcca aatccacttc tggtggcact      420

gctgctctgg gatgcctggt gaaggattac tttcctgaac ctgtgactgt ctcatggaac      480

tctggtgctc tgacttctgg tgtccacact ttccctgctg tgctgcagtc tagtggactg      540

tactctctgt catctgtggt cactgtgccc tcttcatctc tgggaaccca gacctacatt      600

tgtaatgtga accacaaacc atccaacact aaagtggaca aaaaagtgga acccaaatcc      660

tgtgacaaaa cccacacctg cccaccttgt cctgcccctg aactgctggg aggaccttct      720

gtgtttctgt tcccccccaa accaaaggat accctgatga tctctagaac ccctgaggtg      780

acatgtgtgg tggtggatgt gtctcatgag gaccctgagg tcaaattcaa ctggtacgtg      840

gatggagtgg aagtccacaa tgccaaaacc aagcctagag aggaacagta caattcaacc      900

tacagagtgg tcagtgtgct gactgtgctg catcaggatt ggctgaatgg caaggaatac      960

aagtgtaaag tctcaaacaa ggccctgcct gctccaattg agaaaacaat ctcaaaggcc     1020

aagggacagc ctagggaacc ccaggtctac accctgccac cttcaagaga ggaaatgacc     1080

aaaaaccagg tgtccctgac atgcctggtc aaaggcttct acccttctga cattgctgtg     1140

gagtgggagt caaatggaca gcctgagaac aactacaaaa caaccccccc tgtgctggat     1200

tctgatggct ctttctttct gtactccaaa ctgactgtgg acaagtctag atggcagcag     1260

gggaatgtct tttcttgctc tgtcatgcat gaggctctgc ataaccacta cactcagaaa     1320

tccctgtctc tgtctcccgg gaaa                                            1344


<210>  17
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10G5 GH2 Heavy chain nucleic acid

<400>  17
gaggtgcagc tggtggaatc cggcggaggg ctggtgcagc caggtggcag cctgagactg       60

tcttgcgccg cttcaggata ctccttcacc gacttttata tcaactgggt cagacaggcc      120

cccggcaagg gcctggagtg ggtcgctcgc attttccctg gaggggacaa cacatactac      180

aacgaaaagt tcaaaggcag gttcaccctg agtgctgata cttctaaaag taccgcatac      240

ctgcaaatga atagcctgag ggcagaggac acagccgtgt actattgtgc caggcggggc      300

ctgtactatg ctatggatta ttggggacag gggaccctgg tgacagtctc gagcgctagc      360

acaaagggcc ctagtgtgtt tcctctggct ccctcttcca aatccacttc tggtggcact      420

gctgctctgg gatgcctggt gaaggattac tttcctgaac ctgtgactgt ctcatggaac      480

tctggtgctc tgacttctgg tgtccacact ttccctgctg tgctgcagtc tagtggactg      540

tactctctgt catctgtggt cactgtgccc tcttcatctc tgggaaccca gacctacatt      600

tgtaatgtga accacaaacc atccaacact aaagtggaca aaaaagtgga acccaaatcc      660

tgtgacaaaa cccacacctg cccaccttgt cctgcccctg aactgctggg aggaccttct      720

gtgtttctgt tcccccccaa accaaaggat accctgatga tctctagaac ccctgaggtg      780

acatgtgtgg tggtggatgt gtctcatgag gaccctgagg tcaaattcaa ctggtacgtg      840

gatggagtgg aagtccacaa tgccaaaacc aagcctagag aggaacagta caattcaacc      900

tacagagtgg tcagtgtgct gactgtgctg catcaggatt ggctgaatgg caaggaatac      960

aagtgtaaag tctcaaacaa ggccctgcct gctccaattg agaaaacaat ctcaaaggcc     1020

aagggacagc ctagggaacc ccaggtctac accctgccac cttcaagaga ggaaatgacc     1080

aaaaaccagg tgtccctgac atgcctggtc aaaggcttct acccttctga cattgctgtg     1140

gagtgggagt caaatggaca gcctgagaac aactacaaaa caaccccccc tgtgctggat     1200

tctgatggct ctttctttct gtactccaaa ctgactgtgg acaagtctag atggcagcag     1260

gggaatgtct tttcttgctc tgtcatgcat gaggctctgc ataaccacta cactcagaaa     1320

tccctgtctc tgtctcccgg gaaa                                            1344


<210>  18
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain constant region nucleic acid

<400>  18
cgtacggtcg cggcgccttc tgtgttcatt ttccccccat ctgatgaaca gctgaaatct       60

ggcactgctt ctgtggtctg tctgctgaac aacttctacc ctagagaggc caaagtccag      120

tggaaagtgg acaatgctct gcagagtggg aattcccagg aatctgtcac tgagcaggac      180

tctaaggata gcacatactc cctgtcctct actctgacac tgagcaaggc tgattacgag      240

aaacacaaag tgtacgcctg tgaagtcaca catcaggggc tgtctagtcc tgtgaccaaa      300

tccttcaata ggggagagtg c                                                321


<210>  19
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10G5 GL1 Light chain nucleic acid

<400>  19
gacatccaga tgacacagtc tccctccagc ctgagcgcct ctgtgggaga tagagtcacc       60

atcacatgca ggtctagtca gagcctggtg cactctaacg gcatccccta cctgcattgg      120

tatcagcaga agccagggaa agctcccaag ctgctgatct acagagtcag taatcggttc      180

tctggtgtcc cttcgaggtt tagtggctca ggctccggga cagacttcac tctgaccatt      240

tcatccctgc aaccagagga ttttgcaact tactattgta gccagggcac acacgtgccc      300

cctactttcg gtcagggcac caaagtcgaa attaagcgta cggtcgcggc gccttctgtg      360

ttcattttcc ccccatctga tgaacagctg aaatctggca ctgcttctgt ggtctgtctg      420

ctgaacaact tctaccctag agaggccaaa gtccagtgga aagtggacaa tgctctgcag      480

agtgggaatt cccaggaatc tgtcactgag caggactcta aggatagcac atactccctg      540

tcctctactc tgacactgag caaggctgat tacgagaaac acaaagtgta cgcctgtgaa      600

gtcacacatc aggggctgtc tagtcctgtg accaaatcct tcaatagggg agagtgc         657


<210>  20
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10G5 GL2 Light chain nucleic acid

<400>  20
gacatccaga tgacacagtc tccctccagc ctgagcgcct ctgtgggcga tcgagtcacc       60

atcacatgca ggtctagtca gagcctggtg cactctaacg gcattcctta cctgcattgg      120

tatcagcaga agccaggaaa agctcccaag ctgctgatct acagagtcag taatcggttc      180

tctggcgtgc cctccaggtt ctccgggtca cgctccggaa cagacttcac tctgaccatt      240

tcatccctgc aaccagagga ttttgcaact tactattgta gccagggaac acacgtgccc      300

cctactttcg gccagggaac caaagtcgaa attaagcgta cggtcgcggc gccttctgtg      360

ttcattttcc ccccatctga tgaacagctg aaatctggca ctgcttctgt ggtctgtctg      420

ctgaacaact tctaccctag agaggccaaa gtccagtgga aagtggacaa tgctctgcag      480

agtgggaatt cccaggaatc tgtcactgag caggactcta aggatagcac atactccctg      540

tcctctactc tgacactgag caaggctgat tacgagaaac acaaagtgta cgcctgtgaa      600

gtcacacatc aggggctgtc tagtcctgtg accaaatcct tcaatagggg agagtgc         657


<210>  21
<211>  626
<212>  PRT
<213>  Homo sapiens Axl

<400>  21

Met Gly Ile Gln Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr 
1               5                   10                  15      


Ser Gln Ala Ser Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His 
            20                  25                  30          


Pro His Thr Pro Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly 
        35                  40                  45              


Pro Ser Ser Trp Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val 
    50                  55                  60                  


Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln 
65                  70                  75                  80  


Ala Phe Val His Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu 
                85                  90                  95      


Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu 
            100                 105                 110         


Met Asp Ile Gly Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp 
        115                 120                 125             


Gly Ser Val Ser Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala 
    130                 135                 140                 


Gly Asp Gly Pro Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro 
145                 150                 155                 160 


Gly Gln Ala Gln Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro 
                165                 170                 175     


Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala 
            180                 185                 190         


Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys 
        195                 200                 205             


Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly 
    210                 215                 220                 


Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr 
225                 230                 235                 240 


Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu 
                245                 250                 255     


Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys 
            260                 265                 270         


Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn 
        275                 280                 285             


Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala 
    290                 295                 300                 


Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys 
305                 310                 315                 320 


Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys 
                325                 330                 335     


Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu 
            340                 345                 350         


Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg 
        355                 360                 365             


Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe 
    370                 375                 380                 


Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe 
385                 390                 395                 400 


Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met 
                405                 410                 415     


Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly 
            420                 425                 430         


Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile 
        435                 440                 445             


Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val 
    450                 455                 460                 


Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr 
465                 470                 475                 480 


Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln 
                485                 490                 495     


Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala 
            500                 505                 510         


Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe 
        515                 520                 525             


Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro 
    530                 535                 540                 


Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly 
545                 550                 555                 560 


Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr 
                565                 570                 575     


Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val 
            580                 585                 590         


His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro 
        595                 600                 605             


Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp 
    610                 615                 620                 


Gly Ala 
625     


<210>  22
<211>  879
<212>  PRT
<213>  Mus musculus Axl

<400>  22

Met Gly Arg Val Pro Leu Ala Trp Trp Leu Ala Leu Cys Cys Trp Gly 
1               5                   10                  15      


Cys Ala Ala His Lys Asp Thr Gln Thr Glu Ala Gly Ser Pro Phe Val 
            20                  25                  30          


Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu 
        35                  40                  45              


Arg Cys Glu Leu Gln Val Gln Gly Glu Pro Pro Glu Val Val Trp Leu 
    50                  55                  60                  


Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Asn Thr Gln Thr Gln Val 
65                  70                  75                  80  


Pro Leu Gly Glu Asp Trp Gln Asp Glu Trp Lys Val Val Ser Gln Leu 
                85                  90                  95      


Arg Ile Ser Ala Leu Gln Leu Ser Asp Ala Gly Glu Tyr Gln Cys Met 
            100                 105                 110         


Val His Leu Glu Gly Arg Thr Phe Val Ser Gln Pro Gly Phe Val Gly 
        115                 120                 125             


Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Lys Ala Val 
    130                 135                 140                 


Pro Ala Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro 
145                 150                 155                 160 


Glu Pro Val Thr Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Pro 
                165                 170                 175     


Val Thr Gly His Ser Ser Gln His Ser Leu Gln Thr Pro Gly Leu Asn 
            180                 185                 190         


Lys Thr Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr 
        195                 200                 205             


Thr Ser Arg Thr Ala Thr Ile Thr Val Leu Pro Gln Arg Pro His His 
    210                 215                 220                 


Leu His Val Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr 
225                 230                 235                 240 


Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr His Cys Asn Leu Gln Ala 
                245                 250                 255     


Val Leu Ser Asp Asp Gly Val Gly Ile Trp Leu Gly Lys Ser Asp Pro 
            260                 265                 270         


Pro Glu Asp Pro Leu Thr Leu Gln Val Ser Val Pro Pro His Gln Leu 
        275                 280                 285             


Arg Leu Glu Lys Leu Leu Pro His Thr Pro Tyr His Ile Arg Ile Ser 
    290                 295                 300                 


Cys Ser Ser Ser Gln Gly Pro Ser Pro Trp Thr His Trp Leu Pro Val 
305                 310                 315                 320 


Glu Thr Thr Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Val Ser Ala 
                325                 330                 335     


Met Arg Asn Gly Ser Gln Val Leu Val Arg Trp Gln Glu Pro Arg Val 
            340                 345                 350         


Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Arg Gly Gln 
        355                 360                 365             


Asp Thr Pro Glu Val Leu Met Asp Ile Gly Leu Thr Arg Glu Val Thr 
    370                 375                 380                 


Leu Glu Leu Arg Gly Asp Arg Pro Val Ala Asn Leu Thr Val Ser Val 
385                 390                 395                 400 


Thr Ala Tyr Thr Ser Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro 
                405                 410                 415     


Leu Glu Pro Trp Arg Pro Val Ser Glu Pro Pro Pro Arg Ala Phe Ser 
            420                 425                 430         


Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala Leu Val Ala Ala Ala Cys 
        435                 440                 445             


Val Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr 
    450                 455                 460                 


Arg Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val 
465                 470                 475                 480 


Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala 
                485                 490                 495     


Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg 
            500                 505                 510         


Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly 
        515                 520                 525             


Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp 
    530                 535                 540                 


Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr 
545                 550                 555                 560 


Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu 
                565                 570                 575     


Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly 
            580                 585                 590         


Ser Asp Arg Glu Gly Phe Pro Glu Pro Val Val Ile Leu Pro Phe Met 
        595                 600                 605             


Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp 
    610                 615                 620                 


Gln Pro Val Phe Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp 
625                 630                 635                 640 


Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg 
                645                 650                 655     


Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys 
            660                 665                 670         


Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr 
        675                 680                 685             


Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu 
    690                 695                 700                 


Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe 
705                 710                 715                 720 


Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro 
                725                 730                 735     


Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg 
            740                 745                 750         


Leu Lys Gln Pro Val Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser 
        755                 760                 765             


Arg Cys Trp Glu Leu Asn Pro Arg Asp Arg Pro Ser Phe Ala Glu Leu 
    770                 775                 780                 


Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu 
785                 790                 795                 800 


Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Ser His Leu 
                805                 810                 815     


Glu Pro Arg Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp 
            820                 825                 830         


Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Asp Val His Ser Ala 
        835                 840                 845             


Gly Arg Tyr Val Leu Cys Pro Ser Thr Ala Pro Gly Pro Thr Leu Ser 
    850                 855                 860                 


Ala Asp Arg Gly Cys Pro Ala Pro Pro Gly Gln Glu Asp Gly Ala 
865                 870                 875                 


<210>  23
<211>  890
<212>  PRT
<213>  Homo sapiens Tyro3

<400>  23

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 
1               5                   10                  15      


Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Ala Leu Ala Ser 
            20                  25                  30          


Leu Leu Leu Pro Glu Ser Ala Ala Ala Gly Leu Lys Leu Met Gly Ala 
        35                  40                  45              


Pro Val Lys Leu Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys 
    50                  55                  60                  


Ser Val Glu Gly Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly 
65                  70                  75                  80  


Ala Val Val Gln Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln 
                85                  90                  95      


His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Ser Asp Ala 
            100                 105                 110         


Gly Arg Tyr Trp Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser 
        115                 120                 125             


Gln Pro Val Trp Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu 
    130                 135                 140                 


Pro Lys Asp Leu Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys 
145                 150                 155                 160 


Glu Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly 
                165                 170                 175     


Thr Thr Lys Ile Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val 
            180                 185                 190         


Thr Gly Val Thr Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu 
        195                 200                 205             


Lys Gly Leu Ala Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu 
    210                 215                 220                 


Pro Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn 
225                 230                 235                 240 


Ala Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln 
                245                 250                 255     


Ser Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu 
            260                 265                 270         


Ala Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu 
        275                 280                 285             


Val Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu 
    290                 295                 300                 


Gly Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu 
305                 310                 315                 320 


Ala Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser 
                325                 330                 335     


Gly Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu 
            340                 345                 350         


Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr 
        355                 360                 365             


Gln Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp 
    370                 375                 380                 


Asp Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val 
385                 390                 395                 400 


Gly Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 
                405                 410                 415     


Ala Gly Gln Gln Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val 
            420                 425                 430         


Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu 
        435                 440                 445             


Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe 
    450                 455                 460                 


Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala 
465                 470                 475                 480 


Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp 
                485                 490                 495     


Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu 
            500                 505                 510         


Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu 
        515                 520                 525             


Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe 
    530                 535                 540                 


Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser 
545                 550                 555                 560 


Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp 
                565                 570                 575     


His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala 
            580                 585                 590         


Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His 
        595                 600                 605             


Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro 
    610                 615                 620                 


Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala 
625                 630                 635                 640 


Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu 
                645                 650                 655     


Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala 
            660                 665                 670         


Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln 
        675                 680                 685             


Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu 
    690                 695                 700                 


Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val 
705                 710                 715                 720 


Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile 
                725                 730                 735     


Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys 
            740                 745                 750         


Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys 
        755                 760                 765             


Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met 
    770                 775                 780                 


Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln 
785                 790                 795                 800 


Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly 
                805                 810                 815     


Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly 
            820                 825                 830         


Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg 
        835                 840                 845             


Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu 
    850                 855                 860                 


His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu 
865                 870                 875                 880 


Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
                885                 890 


<210>  24
<211>  999
<212>  PRT
<213>  Homo sapiens Mer

<400>  24

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  25
<211>  465
<212>  PRT
<213>  Homo sapiens Akt3

<400>  25

Met Ser Asp Val Thr Ile Val Lys Glu Gly Trp Val Gln Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Asn Trp Arg Pro Arg Tyr Phe Leu Leu Lys Thr Asp 
            20                  25                  30          


Gly Ser Phe Ile Gly Tyr Lys Glu Lys Pro Gln Asp Val Asp Leu Pro 
        35                  40                  45              


Tyr Pro Leu Asn Asn Phe Ser Val Ala Lys Cys Gln Leu Met Lys Thr 
    50                  55                  60                  


Glu Arg Pro Lys Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp Thr 
65                  70                  75                  80  


Thr Val Ile Glu Arg Thr Phe His Val Asp Thr Pro Glu Glu Arg Glu 
                85                  90                  95      


Glu Trp Thr Glu Ala Ile Gln Ala Val Ala Asp Arg Leu Gln Arg Gln 
            100                 105                 110         


Glu Glu Glu Arg Met Asn Cys Ser Pro Thr Ser Gln Ile Asp Asn Ile 
        115                 120                 125             


Gly Glu Glu Glu Met Asp Ala Ser Thr Thr His His Lys Arg Lys Thr 
    130                 135                 140                 


Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys Gly Thr Phe Gly 
145                 150                 155                 160 


Lys Val Ile Leu Val Arg Glu Lys Ala Ser Gly Lys Tyr Tyr Ala Met 
                165                 170                 175     


Lys Ile Leu Lys Lys Glu Val Ile Ile Ala Lys Asp Glu Val Ala His 
            180                 185                 190         


Thr Leu Thr Glu Ser Arg Val Leu Lys Asn Thr Arg His Pro Phe Leu 
        195                 200                 205             


Thr Ser Leu Lys Tyr Ser Phe Gln Thr Lys Asp Arg Leu Cys Phe Val 
    210                 215                 220                 


Met Glu Tyr Val Asn Gly Gly Glu Leu Phe Phe His Leu Ser Arg Glu 
225                 230                 235                 240 


Arg Val Phe Ser Glu Asp Arg Thr Arg Phe Tyr Gly Ala Glu Ile Val 
                245                 250                 255     


Ser Ala Leu Asp Tyr Leu His Ser Gly Lys Ile Val Tyr Arg Asp Leu 
            260                 265                 270         


Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile Lys Ile Thr 
        275                 280                 285             


Asp Phe Gly Leu Cys Lys Glu Gly Ile Thr Asp Ala Ala Thr Met Lys 
    290                 295                 300                 


Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu Glu Asp 
305                 310                 315                 320 


Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly Val Val Met 
                325                 330                 335     


Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln Asp His Glu 
            340                 345                 350         


Lys Leu Phe Glu Leu Ile Leu Met Glu Asp Ile Lys Phe Pro Arg Thr 
        355                 360                 365             


Leu Ser Ser Asp Ala Lys Ser Leu Leu Ser Gly Leu Leu Ile Lys Asp 
    370                 375                 380                 


Pro Asn Lys Arg Leu Gly Gly Gly Pro Asp Asp Ala Lys Glu Ile Met 
385                 390                 395                 400 


Arg His Ser Phe Phe Ser Gly Val Asn Trp Gln Asp Val Tyr Asp Lys 
                405                 410                 415     


Lys Leu Val Pro Pro Phe Lys Pro Gln Val Thr Ser Glu Thr Asp Thr 
            420                 425                 430         


Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Thr Ile Thr Ile Thr Pro 
        435                 440                 445             


Pro Glu Lys Cys Gln Gln Ser Asp Cys Gly Met Leu Gly Asn Trp Lys 
    450                 455                 460                 


Lys 
465 


<210>  26
<211>  678
<212>  PRT
<213>  Homo sapiens Gas6

<400>  26

Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 
            20                  25                  30          


Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 
        35                  40                  45              


Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 
    50                  55                  60                  


Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 
65                  70                  75                  80  


Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 
                85                  90                  95      


Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 
            100                 105                 110         


Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 
        115                 120                 125             


Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 
    130                 135                 140                 


Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys 
145                 150                 155                 160 


Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 
                165                 170                 175     


Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 
        195                 200                 205             


Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 
    210                 215                 220                 


Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp 
225                 230                 235                 240 


Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 
                245                 250                 255     


Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 
            260                 265                 270         


Asp Met Asp Thr Cys Glu Asp Ile Leu Pro Cys Val Pro Phe Ser Val 
        275                 280                 285             


Ala Lys Ser Val Lys Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr 
    290                 295                 300                 


Pro Val Ile Arg Leu Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val 
305                 310                 315                 320 


Ala Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe 
                325                 330                 335     


Ala Gly Gly His Gln Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala 
            340                 345                 350         


Gly Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr 
        355                 360                 365             


Ser Ser Gly Pro Val Ile Asn His Gly Met Trp Gln Thr Ile Ser Val 
    370                 375                 380                 


Glu Glu Leu Ala Arg Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val 
385                 390                 395                 400 


Met Lys Ile Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu 
                405                 410                 415     


Tyr His Leu Asn Leu Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp 
            420                 425                 430         


Leu Val Gln Pro Ile Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp 
        435                 440                 445             


Asn Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val 
    450                 455                 460                 


Asn Thr Arg Met Gln Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr 
465                 470                 475                 480 


Pro Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro 
                485                 490                 495     


Leu Asp Val Gly Thr Glu Ser Thr Trp Glu Val Glu Val Val Ala His 
            500                 505                 510         


Ile Arg Pro Ala Ala Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro 
        515                 520                 525             


Asp Leu Arg Ala Val Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser 
    530                 535                 540                 


Thr Lys Lys Leu Lys Lys Gln Leu Val Val Leu Ala Val Glu His Thr 
545                 550                 555                 560 


Ala Leu Ala Leu Met Glu Ile Lys Val Cys Asp Gly Gln Glu His Val 
                565                 570                 575     


Val Thr Val Ser Leu Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly 
            580                 585                 590         


Thr Arg Gly Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu 
        595                 600                 605             


Ala Val Leu Glu Arg His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly 
    610                 615                 620                 


Gly Leu Pro Asp Val Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr 
625                 630                 635                 640 


Arg Gly Cys Met Thr Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp 
                645                 650                 655     


Glu Ala Ala Tyr Lys His Ser Asp Ile Thr Ala His Ser Cys Pro Pro 
            660                 665                 670         


Val Glu Pro Ala Ala Ala 
        675             


<210>  27
<211>  894
<212>  PRT
<213>  Macaca fascicularis Axl

<400>  27

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Val Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Ala Ser Leu Gln Leu Ser Asp Ala 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Asn Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Asn Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Leu Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Thr Ser Ala Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Ile Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Leu Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ser Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Ala Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  28
<211>  118
<212>  PRT
<213>  Mus musculus 10G5 VH domain

<400>  28

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Phe 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Ile 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  29
<211>  112
<212>  PRT
<213>  Mus musculus 10G5 VL domain

<400>  29

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Ile Pro Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Gly 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 VH CDR1

<400>  30

Gly Tyr Ser Phe Thr Asp Phe Tyr Ile Asn 
1               5                   10  


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 VH CDR2

<400>  31

Arg Ile Phe Pro Gly Gly Asp Asn Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 VH CDR3

<400>  32

Arg Gly Leu Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 VL CDR1

<400>  33

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Ile Pro Tyr Leu His 
1               5                   10                  15      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 VL CDR2

<400>  34

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10G5 VL CDR3

<400>  35

Ser Gln Gly Thr His Val Pro Pro Thr 
1               5                   


