                         SEQUENCE LISTING

<110>  YALE UNIVERSITY
       HANSEN, JAMES
       ZHOU, JIANGBING
 
<120>  ANTI-GUANOSINE ANTIBODY AS A MOLECULAR DELIVERY VEHICLE

<130>  YU 7041 PCT

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  1

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ile Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  2
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  2

Arg Ala Ser Gln Ser Ile Ser Asn Tyr Leu His 
1               5                   10      


<210>  3
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  3

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  4
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  5
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  5

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Ser Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Leu Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Tyr Thr Met Tyr Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  6
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Tyr Tyr Met Asn 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  7

Arg Val Asn Pro Ser Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  8

Gly Pro Tyr Thr Met Tyr Tyr 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  9

Gly Gln Ser Ser Arg Ser Ser 
1               5           


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  10

Gly Gln Ser Ser Arg Ser Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  11

Gly Ser Gly Ser 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  12

Gly Gly Gly Ser 
1               


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  16

Arg Ala Asp Ala Ala Pro 
1               5       


<210>  17
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  18

Leu Glu Ser Ser Gly Ser 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  19

Pro Leu Gly Leu Ala Gly 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  20

Arg Leu Gln Leu Lys Leu 
1               5       


<210>  21
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  21

Ala Gly Ile His Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
1               5                   10                  15      


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser 
            20                  25                  30          


Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser 
    50                  55                  60                  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln His Ser Arg Glu Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys Arg Ala Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala 
145                 150                 155                 160 


Ser Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala 
                165                 170                 175     


Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser 
            180                 185                 190         


Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser 
    210                 215                 220                 


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys 
                245                 250                 255     


Gly Pro Ser Val Phe Pro Leu Ala Pro Leu Glu Ser Ser Gly Ser Asp 
            260                 265                 270         


Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln 
        275                 280                 285             


Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ser 
    290                 295                 300                 


Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Lys Tyr Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala Arg 
                325                 330                 335     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His Pro 
            340                 345                 350         


Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
        355                 360                 365             


Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
    370                 375                 380                 


Asp Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
                405                 410                 415     


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            420                 425                 430         


Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
        435                 440                 445             


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Ile Tyr Tyr Ala 
    450                 455                 460                 


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
465                 470                 475                 480 


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
                485                 490                 495     


Tyr Tyr Cys Ala Arg Arg Gly Leu Leu Leu Asp Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Thr Leu Thr Val Ser Ser Leu Glu Gln Lys Leu Ile Ser Glu Glu 
        515                 520                 525             


Asp Leu Asn Ser Ala Val Asp His His His His His His 
    530                 535                 540     


<210>  22
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  22

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ile Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Asp Ala Ala Pro 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
145                 150                 155                 160 


Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
                165                 170                 175     


Arg Val Asn Pro Ser Asn Gly Gly Ile Ser Tyr Asn Gln Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Leu Ser Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Gly Pro Tyr Thr Met Tyr Tyr Trp Gly Gln Gly Thr Ser Val Thr 
225                 230                 235                 240 


Val Ser Ser His His His His His His 
                245                 


<210>  23
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  23

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val 
            20                  25                  30          


Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ile Ser 
                85                  90                  95      


Val Glu Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser 
            100                 105                 110         


Trp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Ala Asp 
        115                 120                 125             


Ala Ala Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
145                 150                 155                 160 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                165                 170                 175     


Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
            180                 185                 190         


Trp Ile Gly Arg Val Asn Pro Ser Asn Gly Gly Ile Ser Tyr Asn Gln 
        195                 200                 205             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Leu Ser Thr 
    210                 215                 220                 


Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Arg Gly Pro Tyr Thr Met Tyr Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser His His His His His His 
            260                 265             


<210>  24
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  24
gaattcccgc cgccaccatg ggctggtcct gcatcattct gtttctggtg gccacagcca       60

ccggcgtgca ctctgatatt gtgctgacac agagccccgc cacactgtct gttacccctg      120

gcgatagagt gtccctgagc tgtagagcca gccagagcat cagcaactac ctgcactggt      180

atcagcagaa gtcccacgag agccccagac tgctgattaa gtacgccagc cagtctatca      240

gcggcatccc cagcagattt tctggcagcg gctctggcac cgacttcacc ctgtctatca      300

tcagcgtgga aaccgaggac ttcgggatgt acttctgcca gcagtccaac agctggcccc      360

tgacatttgg cgccggaaca aagctggaac tgaaggccga tgctgctcct ggtggcggag      420

gatctggcgg aggtggaagc ggcggaggcg gatctgaagt tcagctgcag caaagcggac      480

ccgagctggt taagcctggc gcctctgtga agatgagctg caaggccagc ggctacacct      540

tcaccgacta ctacatgaac tgggtcaagc agagccacgg caagagcctg gaatggatcg      600

gcagagtgaa ccccagcaat ggcggcatca gctacaacca gaagttcaag ggcaaagcca      660

cactgaccgt ggataagagc ctgagcaccg cctacatgca gctcaacagc ctgaccagcg      720

aggacagcgc cgtgtactat tgtgccagag gaccctacac catgtactac tggggccagg      780

gcacaagcgt gaccgtgtct agccaccacc accatcacca ctgataagct t               831


