                         SEQUENCE LISTING

<110>  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
 
<120>  INFLUENZA VIRUS HEMAGLUTTININ PROTEINS AND USES THEREOF

<130>  6923-261-228

<140>  TBA
<141>  On even date herewith

<150>  62/350,701
<151>  2016-06-15

<150>  62/355,679
<151>  2016-06-28

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Yamagata/16/88 120 loop

<400>  1

Asn Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Arg Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  2
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with 
amino acids from A/Vietnam/1203/04 

<400>  2

Lys Ile Gln Leu Ser Thr Lys Asn Val Ile Asn Ala Glu His Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Yamagata/16/88 150 loop

<400>  3

Asn Val Thr Ser Arg Asn Gly 
1               5           


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted 
with amino acids from A/Vietnam/1203/04 

<400>  4

Tyr Gln Gly Lys Ser Ser 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Yamagata/16/88 160 loop

<400>  5

Arg Asp Asn Lys Thr Ala 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with 
amino acids from A/Vietnam/1203/04 

<400>  6

Lys Lys Asn Ser Thr Tyr 
1               5       


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Yamagata/16/88 190 helix

<400>  7

Asn Lys Asn Gln Met Lys Asn 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted 
with amino acids from A/Vietnam/1203/04 

<400>  8

Asn Asp Ala Ala Met Gln Thr 
1               5           


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA signal peptide

<400>  9

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala 
1               5                   10                  15  


<210>  10
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA HA1 polypeptide (no signal peptide)

<400>  10

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Met Gly Thr Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Ala Arg Asn Val Thr Asn Ala Glu 
        115                 120                 125             


Thr Ala Pro Gly Gly Pro Tyr Ile Val Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
                165                 170                 175     


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
            180                 185                 190         


Asp Asp Glu Thr Gln Met Val Lys Leu Tyr Gly Asp Ser Lys Pro Gln 
        195                 200                 205             


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
    210                 215                 220                 


Ile Gly Gly Phe Pro Asn Gln Ala Glu Asp Glu Gly Leu Pro Gln Ser 
225                 230                 235                 240 


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
                245                 250                 255     


Thr Ile Ala Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
            260                 265                 270         


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
        275                 280                 285             


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
    290                 295                 300                 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
305                 310                 315                 320 


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
                325                 330                 335     


Pro Ala Lys Leu Leu Lys Glu Arg 
            340                 


<210>  11
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA HA2 polypeptide (no stop codon)

<400>  11

Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly Val 
            20                  25                  30          


Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile 
        35                  40                  45              


Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln 
    50                  55                  60                  


Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile 
                85                  90                  95      


Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp 
            100                 105                 110         


Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro 
        115                 120                 125             


Ser Ala Val Asp Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys 
    130                 135                 140                 


Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly 
145                 150                 155                 160 


Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser 
                165                 170                 175     


Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser 
            180                 185                 190         


Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala Ile Phe Ile 
        195                 200                 205             


Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
    210                 215                 220             


<210>  12
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Ectodomain  (excludes signal peptide, 
transmembrane domain, cytoplasmic tail domain)

<400>  12

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Met Gly Thr Ile Pro Ser Ala Lys 
65                  70                  75                  80  


Ala Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu Asn Ile Arg Leu Ser Ala Arg Asn Val Thr Asn Ala Glu 
        115                 120                 125             


Thr Ala Pro Gly Gly Pro Tyr Ile Val Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
                165                 170                 175     


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
            180                 185                 190         


Asp Asp Glu Thr Gln Met Val Lys Leu Tyr Gly Asp Ser Lys Pro Gln 
        195                 200                 205             


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
    210                 215                 220                 


Ile Gly Gly Phe Pro Asn Gln Ala Glu Asp Glu Gly Leu Pro Gln Ser 
225                 230                 235                 240 


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
                245                 250                 255     


Thr Ile Ala Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
            260                 265                 270         


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
        275                 280                 285             


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
    290                 295                 300                 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
305                 310                 315                 320 


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
                325                 330                 335     


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
        355                 360                 365             


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
385                 390                 395                 400 


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
                405                 410                 415     


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
            420                 425                 430         


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
        435                 440                 445             


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
    450                 455                 460                 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
                485                 490                 495     


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
            500                 505                 510         


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
        515                 520                 525             


His Thr 
    530 


<210>  13
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Transmembrane domain

<400>  13

Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr Leu 
1               5                   10                  15      


Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser 
            20                  25          


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Cytoplasmic domain (no stop codon)


<400>  14

Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
1               5                   10  


<210>  15
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Stem domain (encompasses alanines at 
interface; no signal peptide or stop codon) Piece 1:

<400>  15

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala 
        35                  40          


<210>  16
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Stem domain (encompasses alanines at 
interface; no signal peptide or stop codon) Piece 2:

<400>  16

Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
1               5                   10                  15      


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
            20                  25                  30          


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
        35                  40                  45              


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
    50                  55                  60                  


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
65                  70                  75                  80  


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
                85                  90                  95      


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
            100                 105                 110         


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
        115                 120                 125             


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
    130                 135                 140                 


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
145                 150                 155                 160 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
                165                 170                 175     


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
            180                 185                 190         


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
        195                 200                 205             


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
    210                 215                 220                 


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
225                 230                 235                 240 


Thr 
    


<210>  17
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B/Hong Kong/8/73 HA Globular head domain 
(not including alanines)

<400>  17

Asn Leu Lys Gly Thr Gln Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu 
1               5                   10                  15      


Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys Met Gly 
            20                  25                  30          


Thr Ile Pro Ser Ala Lys Ala Ser Ile Leu His Glu Val Lys Pro Val 
        35                  40                  45              


Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln 
    50                  55                  60                  


Leu Pro Asn Leu Leu Arg Gly Tyr Glu Asn Ile Arg Leu Ser Ala Arg 
65                  70                  75                  80  


Asn Val Thr Asn Ala Glu Thr Ala Pro Gly Gly Pro Tyr Ile Val Gly 
                85                  90                  95      


Thr Ser Gly Ser Cys Pro Asn Val Thr Asn Gly Asn Gly Phe Phe Ala 
            100                 105                 110         


Thr Met Ala Trp Ala Val Pro Lys Asn Lys Thr Ala Thr Asn Pro Leu 
        115                 120                 125             


Thr Val Glu Val Pro Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr 
    130                 135                 140                 


Val Trp Gly Phe His Ser Asp Asp Glu Thr Gln Met Val Lys Leu Tyr 
145                 150                 155                 160 


Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr 
                165                 170                 175     


Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Ala Glu Asp 
            180                 185                 190         


Glu Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln 
        195                 200                 205             


Lys Pro Gly Lys Thr Gly Thr Ile Ala Tyr Gln Arg Gly Val Leu Leu 
    210                 215                 220                 


Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly 
225                 230                 235                 240 


Ser Leu Pro Leu Ile Gly Glu 
                245         


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  influenza B/Yamagata/16/88 virus HA 150 loop (including N terminal P)

<400>  18

Pro Asn Val Thr Ser Arg Asn Gly 
1               5               


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from influenza A/Vietnam/1203/04(HALo) virus globular head 
domain (including N terminal P)

<400>  19

Pro Tyr Gln Gly Lys Ser Ser 
1               5           


<210>  20
<211>  1862
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding H5-4 loop chimeric HA for 
rescue in PR8

<400>  20
ccgaagttgg gggggagcaa aagcagggga aaataaaaac aaccaaaatg aaggcaaacc       60

tactggtcct gttaagtgca cttgcagctg cagatgcaga tcgaatctgc actgggataa      120

catcttcaaa ctcacctcat gtggtcaaaa cagctactca aggggaagtt aatgtgactg      180

gtgtgatacc actgacaaca acaccaacaa aatctcattt tgcaaatctc aaaggaacaa      240

agaccagagg gaaactatgc ccaaactgtc tcaactgcac agatctggat gtggccttgg      300

gcagaccaat gtgtatgggg ttcatacctt cggcaaaagc ttcaatactc cacgaagtca      360

gacctgttac atccgggtgc tttcctataa tgcacgacag aacaaaaatc agacagctac      420

ccaatcttct cagaggatat gaaaaaatcc agttatcaac caaaaacgtt atcaacgcag      480

aacatgcacc aggaggaccc tacagacttg gaacctcaga atcttgccca taccagggaa      540

agtcctcctt cttcgcaaca atggcttggg ctgtcccaaa aaagaacagt acatacacga      600

atccactaac agtagaagta ccatacattt gcacaaaagg agaagaccaa attactgttt      660

gggggttcca ttctgataat gatgcggcaa tgcagacact ctatggagac tcaaatcctc      720

aaaagttcac ctcatctgcc aatggagtaa ccacacatta tgtttctcag attggtgact      780

tcccaaatca aacagaagac ggagggctac cacaaagcgg cagaattgtt gttgattaca      840

tggtgcaaaa acctgggaaa acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc      900

aaaaggtgtg gtgcgcaagt ggcaggagca aggtaataaa agggtccttg cctttaattg      960

gtgaagcaga ttgccttcac gaaaaatacg gtggattaaa caaaagcaag ccttactaca     1020

caggagaaca tgcaaaagcc ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc     1080

ttgccaatgg aaccaaatat agacctcctg caaaactatt aaaggaaagg ggtttcttcg     1140

gagctattgc tggtttctta gagggaggat gggaaggaat gattgcaggt tggcacggat     1200

acacatctca tggagcacat ggagtggcag tggcagcaga ccttaagagc acgcaagaag     1260

ccataaacaa gataacaaaa aatctcaatt ctttgagtga gctagaagta aagaatcttc     1320

aaagactaag tggtgccatg gatgaactcc acaacgaaat actcgagctg gatgagaaag     1380

tggatgatct cagagctgac acaataagct cgcaaataga gcttgcagtc ttgctttcca     1440

acgaaggaat aataaacagt gaagatgagc atctattggc acttgagaga aaactaaaga     1500

aaatgctggg tccctctgct gtagacatag ggaatggatg cttcgaaacc aaacacaagt     1560

gcaaccagac ctgcttagac aggatagctg ctggcacctt taatgcagga gaattttctc     1620

ttcccacttt tgattcactg aatattactg ctgcatcttt aaatgatgat ggattggata     1680

attatcagat tctggcgatc tactcaactg tcgccagttc actggtgctt ttggtctccc     1740

tgggggcaat cagtttctgg atgtgttcta atggatcttt gcagtgcaga atatgcatct     1800

gagattagaa tttcagaaat atgaggaaaa acacccttgt ttctactaat aacccggcgg     1860

cc                                                                    1862


<210>  21
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H5-4 loop chimeric HA for rescue in PR8

<400>  21

Met Lys Ala Asn Leu Leu Val Leu Leu Ser Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val 
            20                  25                  30          


Val Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro 
        35                  40                  45              


Leu Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr 
    50                  55                  60                  


Lys Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu 
65                  70                  75                  80  


Asp Val Ala Leu Gly Arg Pro Met Cys Met Gly Phe Ile Pro Ser Ala 
                85                  90                  95      


Lys Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe 
            100                 105                 110         


Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu 
        115                 120                 125             


Arg Gly Tyr Glu Lys Ile Gln Leu Ser Thr Lys Asn Val Ile Asn Ala 
    130                 135                 140                 


Glu His Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Glu Ser Cys 
145                 150                 155                 160 


Pro Tyr Gln Gly Lys Ser Ser Phe Phe Ala Thr Met Ala Trp Ala Val 
                165                 170                 175     


Pro Lys Lys Asn Ser Thr Tyr Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Asp Ala Ala Met Gln Thr Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val 
545                 550                 555                 560 


Leu Leu Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly 
                565                 570                 575     


Ser Leu Gln Cys Arg Ile Cys Ile 
            580                 


<210>  22
<211>  1868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding H8-4 loop chimeric HA for 
rescue in PR8

<400>  22
ccgaagttgg gggggagcaa aagcagggga aaataaaaac aaccaaaatg aaggcaaacc       60

tactggtcct gttaagtgca cttgcagctg cagatgcaga tcgaatctgc actgggataa      120

catcttcaaa ctcacctcat gtggtcaaaa cagctactca aggggaagtt aatgtgactg      180

gtgtgatacc actgacaaca acaccaacaa aatctcattt tgcaaatctc aaaggaacaa      240

agaccagagg gaaactatgc ccaaactgtc tcaactgcac agatctggat gtggccttgg      300

gcagaccaat gtgtatgggg cacatacctt cggcaaaagc ttcaatactc cacgaagtca      360

gacctgttac atccgggtgc tttcctataa tgcacgacag aacaaaaatc agacagctac      420

ccaatcttct cagaggatat gaaaggatca gattatcaac ctacaacgtt atcaacgcag      480

aaaccgcacc aggaggaccc tacagacttg gaacctcaaa atcttgcaat gcttcaacag      540

gaggccaatc tttcttcgca acaatggctt gggctgtccc aaaaaagaaa cccgacacct      600

atacgaatcc actaacagta gaagtaccat acatttgcac aaaaggagaa gaccaaatta      660

ctgtttgggg gttccattct gatccggatg caaaaatgca aacactctat ggagactcaa      720

atcctcaaaa gttcacctca tctgccaatg gagtaaccac acattatgtt tctcagattg      780

gtgacttccc aaatcaaaca gaagacggag ggctaccaca aagcggcaga attgttgttg      840

attacatggt gcaaaaacct gggaaaacag gaacaattgt ctatcaaaga ggtgttttgt      900

tgcctcaaaa ggtgtggtgc gcaagtggca ggagcaaggt aataaaaggg tccttgcctt      960

taattggtga agcagattgc cttcacgaaa aatacggtgg attaaacaaa agcaagcctt     1020

actacacagg agaacatgca aaagccatag gaaattgccc aatatgggtg aaaacacctt     1080

tgaagcttgc caatggaacc aaatatagac ctcctgcaaa actattaaag gaaaggggtt     1140

tcttcggagc tattgctggt ttcttagagg gaggatggga aggaatgatt gcaggttggc     1200

acggatacac atctcatgga gcacatggag tggcagtggc agcagacctt aagagcacgc     1260

aagaagccat aaacaagata acaaaaaatc tcaattcttt gagtgagcta gaagtaaaga     1320

atcttcaaag actaagtggt gccatggatg aactccacaa cgaaatactc gagctggatg     1380

agaaagtgga tgatctcaga gctgacacaa taagctcgca aatagagctt gcagtcttgc     1440

tttccaacga aggaataata aacagtgaag atgagcatct attggcactt gagagaaaac     1500

taaagaaaat gctgggtccc tctgctgtag acatagggaa tggatgcttc gaaaccaaac     1560

acaagtgcaa ccagacctgc ttagacagga tagctgctgg cacctttaat gcaggagaat     1620

tttctcttcc cacttttgat tcactgaata ttactgctgc atctttaaat gatgatggat     1680

tggataatta tcagattctg gcgatctact caactgtcgc cagttcactg gtgcttttgg     1740

tctccctggg ggcaatcagt ttctggatgt gttctaatgg atctttgcag tgcagaatat     1800

gcatctgaga ttagaatttc agaaatatga ggaaaaacac ccttgtttct actaataacc     1860

cggcggcc                                                              1868


<210>  23
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H8-4 loop chimeric HA for rescue in PR8

<400>  23

Met Lys Ala Asn Leu Leu Val Leu Leu Ser Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val 
            20                  25                  30          


Val Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro 
        35                  40                  45              


Leu Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr 
    50                  55                  60                  


Lys Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu 
65                  70                  75                  80  


Asp Val Ala Leu Gly Arg Pro Met Cys Met Gly His Ile Pro Ser Ala 
                85                  90                  95      


Lys Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe 
            100                 105                 110         


Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu 
        115                 120                 125             


Arg Gly Tyr Glu Arg Ile Arg Leu Ser Thr Tyr Asn Val Ile Asn Ala 
    130                 135                 140                 


Glu Thr Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Lys Ser Cys 
145                 150                 155                 160 


Asn Ala Ser Thr Gly Gly Gln Ser Phe Phe Ala Thr Met Ala Trp Ala 
                165                 170                 175     


Val Pro Lys Lys Lys Pro Asp Thr Tyr Thr Asn Pro Leu Thr Val Glu 
            180                 185                 190         


Val Pro Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly 
        195                 200                 205             


Phe His Ser Asp Pro Asp Ala Lys Met Gln Thr Leu Tyr Gly Asp Ser 
    210                 215                 220                 


Asn Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr 
225                 230                 235                 240 


Val Ser Gln Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu 
                245                 250                 255     


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly 
            260                 265                 270         


Lys Thr Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys 
        275                 280                 285             


Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro 
    290                 295                 300                 


Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
305                 310                 315                 320 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
                325                 330                 335     


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
            340                 345                 350         


Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala 
        355                 360                 365             


Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp 
    370                 375                 380                 


His Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp 
385                 390                 395                 400 


Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn 
                405                 410                 415     


Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala 
            420                 425                 430         


Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp 
        435                 440                 445             


Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
    450                 455                 460                 


Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
465                 470                 475                 480 


Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile 
                485                 490                 495     


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
            500                 505                 510         


Asp Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro 
        515                 520                 525             


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly 
    530                 535                 540                 


Leu Asp Asn Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser 
545                 550                 555                 560 


Leu Val Leu Leu Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser 
                565                 570                 575     


Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
            580                 585     


<210>  24
<211>  1862
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding H11-4 loop chimeric HA for 
rescue in PR8

<400>  24
ccgaagttgg gggggagcaa aagcagggga aaataaaaac aaccaaaatg aaggcaaacc       60

tactggtcct gttaagtgca cttgcagctg cagatgcaga tcgaatctgc actgggataa      120

catcttcaaa ctcacctcat gtggtcaaaa cagctactca aggggaagtt aatgtgactg      180

gtgtgatacc actgacaaca acaccaacaa aatctcattt tgcaaatctc aaaggaacaa      240

agaccagagg gaaactatgc ccaaactgtc tcaactgcac agatctggat gtggccttgg      300

gcagaccaat gtgtatgggg ctaatacctt cggcaaaagc ttcaatactc cacgaagtca      360

gacctgttac atccgggtgc tttcctataa tgcacgacag aacaaaaatc agacagctac      420

ccaatcttct cagaggatat gaaaagatcg aattatcaac ctcaaacgtt atcaacgcag      480

aagtggcacc aggaggaccc tacagacttg gaacctcaaa atcttgcaaa ttcggaagct      540

ccaattcttt cttcgcaaca atggcttggg ctgtcccaca tcaatcagga acatatacga      600

atccactaac agtagaagta ccatacattt gcacaaaagg agaagaccaa attactgttt      660

gggggttcca ttctgatgcc acactgaaaa tgcaccaact ctatggagac tcaaatcctc      720

aaaagttcac ctcatctgcc aatggagtaa ccacacatta tgtttctcag attggtgact      780

tcccaaatca aacagaagac ggagggctac cacaaagcgg cagaattgtt gttgattaca      840

tggtgcaaaa acctgggaaa acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc      900

aaaaggtgtg gtgcgcaagt ggcaggagca aggtaataaa agggtccttg cctttaattg      960

gtgaagcaga ttgccttcac gaaaaatacg gtggattaaa caaaagcaag ccttactaca     1020

caggagaaca tgcaaaagcc ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc     1080

ttgccaatgg aaccaaatat agacctcctg caaaactatt aaaggaaagg ggtttcttcg     1140

gagctattgc tggtttctta gagggaggat gggaaggaat gattgcaggt tggcacggat     1200

acacatctca tggagcacat ggagtggcag tggcagcaga ccttaagagc acgcaagaag     1260

ccataaacaa gataacaaaa aatctcaatt ctttgagtga gctagaagta aagaatcttc     1320

aaagactaag tggtgccatg gatgaactcc acaacgaaat actcgagctg gatgagaaag     1380

tggatgatct cagagctgac acaataagct cgcaaataga gcttgcagtc ttgctttcca     1440

acgaaggaat aataaacagt gaagatgagc atctattggc acttgagaga aaactaaaga     1500

aaatgctggg tccctctgct gtagacatag ggaatggatg cttcgaaacc aaacacaagt     1560

gcaaccagac ctgcttagac aggatagctg ctggcacctt taatgcagga gaattttctc     1620

ttcccacttt tgattcactg aatattactg ctgcatcttt aaatgatgat ggattggata     1680

attatcagat tctggcgatc tactcaactg tcgccagttc actggtgctt ttggtctccc     1740

tgggggcaat cagtttctgg atgtgttcta atggatcttt gcagtgcaga atatgcatct     1800

gagattagaa tttcagaaat atgaggaaaa acacccttgt ttctactaat aacccggcgg     1860

cc                                                                    1862


<210>  25
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H11-4 loop chimeric HA for rescue in PR8

<400>  25

Met Lys Ala Asn Leu Leu Val Leu Leu Ser Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val 
            20                  25                  30          


Val Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro 
        35                  40                  45              


Leu Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr 
    50                  55                  60                  


Lys Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu 
65                  70                  75                  80  


Asp Val Ala Leu Gly Arg Pro Met Cys Met Gly Leu Ile Pro Ser Ala 
                85                  90                  95      


Lys Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe 
            100                 105                 110         


Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu 
        115                 120                 125             


Arg Gly Tyr Glu Lys Ile Glu Leu Ser Thr Ser Asn Val Ile Asn Ala 
    130                 135                 140                 


Glu Val Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Lys Ser Cys 
145                 150                 155                 160 


Lys Phe Gly Ser Ser Asn Ser Phe Phe Ala Thr Met Ala Trp Ala Val 
                165                 170                 175     


Pro His Gln Ser Gly Thr Tyr Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Ala Thr Leu Lys Met His Gln Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val 
545                 550                 555                 560 


Leu Leu Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly 
                565                 570                 575     


Ser Leu Gln Cys Arg Ile Cys Ile 
            580                 


<210>  26
<211>  1865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding H12-4 loop chimeric HA for 
rescue in PR8

<400>  26
ccgaagttgg gggggagcaa aagcagggga aaataaaaac aaccaaaatg aaggcaaacc       60

tactggtcct gttaagtgca cttgcagctg cagatgcaga tcgaatctgc actgggataa      120

catcttcaaa ctcacctcat gtggtcaaaa cagctactca aggggaagtt aatgtgactg      180

gtgtgatacc actgacaaca acaccaacaa aatctcattt tgcaaatctc aaaggaacaa      240

agaccagagg gaaactatgc ccaaactgtc tcaactgcac agatctggat gtggccttgg      300

gcagaccaat gtgtatgggg tatatacctt cggcaaaagc ttcaatactc cacgaagtca      360

gacctgttac atccgggtgc tttcctataa tgcacgacag aacaaaaatc agacagctac      420

ccaatcttct cagaggatat gaaagaatca agttatcaac cttcaacgtt atcaacgcag      480

aaacggcacc aggaggaccc tacagacttg gaacctcaaa atcttgcaac aatacatcaa      540

accaaggctc attcttcgca acaatggctt gggctgtccc attaaaatca ggacaattca      600

cgaatccact aacagtagaa gtaccataca tttgcacaaa aggagaagac caaattactg      660

tttgggggtt ccattctgat ccaacatctg atatgcagat actctatgga gactcaaatc      720

ctcaaaagtt cacctcatct gccaatggag taaccacaca ttatgtttct cagattggtg      780

acttcccaaa tcaaacagaa gacggagggc taccacaaag cggcagaatt gttgttgatt      840

acatggtgca aaaacctggg aaaacaggaa caattgtcta tcaaagaggt gttttgttgc      900

ctcaaaaggt gtggtgcgca agtggcagga gcaaggtaat aaaagggtcc ttgcctttaa      960

ttggtgaagc agattgcctt cacgaaaaat acggtggatt aaacaaaagc aagccttact     1020

acacaggaga acatgcaaaa gccataggaa attgcccaat atgggtgaaa acacctttga     1080

agcttgccaa tggaaccaaa tatagacctc ctgcaaaact attaaaggaa aggggtttct     1140

tcggagctat tgctggtttc ttagagggag gatgggaagg aatgattgca ggttggcacg     1200

gatacacatc tcatggagca catggagtgg cagtggcagc agaccttaag agcacgcaag     1260

aagccataaa caagataaca aaaaatctca attctttgag tgagctagaa gtaaagaatc     1320

ttcaaagact aagtggtgcc atggatgaac tccacaacga aatactcgag ctggatgaga     1380

aagtggatga tctcagagct gacacaataa gctcgcaaat agagcttgca gtcttgcttt     1440

ccaacgaagg aataataaac agtgaagatg agcatctatt ggcacttgag agaaaactaa     1500

agaaaatgct gggtccctct gctgtagaca tagggaatgg atgcttcgaa accaaacaca     1560

agtgcaacca gacctgctta gacaggatag ctgctggcac ctttaatgca ggagaatttt     1620

ctcttcccac ttttgattca ctgaatatta ctgctgcatc tttaaatgat gatggattgg     1680

ataattatca gattctggcg atctactcaa ctgtcgccag ttcactggtg cttttggtct     1740

ccctgggggc aatcagtttc tggatgtgtt ctaatggatc tttgcagtgc agaatatgca     1800

tctgagatta gaatttcaga aatatgagga aaaacaccct tgtttctact aataacccgg     1860

cggcc                                                                 1865


<210>  27
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of H12-4 loop chimeric HA for rescue in PR8

<400>  27

Met Lys Ala Asn Leu Leu Val Leu Leu Ser Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val 
            20                  25                  30          


Val Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro 
        35                  40                  45              


Leu Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr 
    50                  55                  60                  


Lys Thr Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu 
65                  70                  75                  80  


Asp Val Ala Leu Gly Arg Pro Met Cys Met Gly Tyr Ile Pro Ser Ala 
                85                  90                  95      


Lys Ala Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe 
            100                 105                 110         


Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu 
        115                 120                 125             


Arg Gly Tyr Glu Arg Ile Lys Leu Ser Thr Phe Asn Val Ile Asn Ala 
    130                 135                 140                 


Glu Thr Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Lys Ser Cys 
145                 150                 155                 160 


Asn Asn Thr Ser Asn Gln Gly Ser Phe Phe Ala Thr Met Ala Trp Ala 
                165                 170                 175     


Val Pro Leu Lys Ser Gly Gln Phe Thr Asn Pro Leu Thr Val Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Pro Thr Ser Asp Met Gln Ile Leu Tyr Gly Asp Ser Asn 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu 
545                 550                 555                 560 


Val Leu Leu Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn 
                565                 570                 575     


Gly Ser Leu Gln Cys Arg Ile Cys Ile 
            580                 585 


<210>  28
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza B/Hong Kong/8/73 virus HA

<400>  28

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Gln Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Met Gly Thr Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Lys Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Ala Arg Asn Val Thr Asn Ala Glu Thr 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Ile Val Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asp Glu Thr Gln Met Val Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Gly Phe Pro Asn Gln Ala Glu Asp Glu Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Ala Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  29
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza A/Puerto Rico/8/34 virus HA

<400>  29

Met Lys Ala Asn Leu Leu Val Leu Leu Ser Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Ile Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Thr Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  30
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza B/Yamagata/16/88 virus HA

<400>  30

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Thr Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Arg 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Glu Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Ser Arg Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Arg Asp Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
            180                 185                 190         


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
        195                 200                 205             


Asp Asn Lys Asn Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln 
    210                 215                 220                 


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
225                 230                 235                 240 


Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser 
                245                 250                 255     


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
            260                 265                 270         


Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
        275                 280                 285             


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
    290                 295                 300                 


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
305                 310                 315                 320 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
                325                 330                 335     


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
            340                 345                 350         


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
        355                 360                 365             


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
    370                 375                 380                 


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
385                 390                 395                 400 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
                405                 410                 415     


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
            420                 425                 430         


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
        435                 440                 445             


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    450                 455                 460                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
465                 470                 475                 480 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
                485                 490                 495     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            500                 505                 510         


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        515                 520                 525             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
    530                 535                 540                 


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
545                 550                 555                 560 


Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn 
                565                 570                 575     


Val Ser Cys Ser Ile Cys Leu 
            580             


<210>  31
<211>  1742
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding influenza A/mallard/Sweden/24/2002 
virus HA

<400>  31
gcaaaagcag gggtcacaat ggagaagttc atcataatgg caatgctctt ggtgagcaca       60

aatgcatatg ataggatatg cattggatac caatcaaaca actccactga cacagtaaac      120

acactcatag agcaaaatgt gccagtcacc cagacaatgg aactagtgga aaccgagaaa      180

catcctgcct attgcaatac tgatttgggt gctccactag agttgcgtga ttgcaagatt      240

gaggcggtga tctatgggaa cccaaaatgt gacatccact tgaaagacca aggttggtca      300

tacatagtgg agagacccag tgcaccagag gggatgtgct accctggatc agtggagaat      360

ctcgaagagt tgaggtttgt tttctccagt gctgcttcct acaaaaggat aagattgttt      420

gattactcca gatggaatgt taccagatct gggacaagca aggcatgcaa tgcttcaaca      480

ggaggccaat ctttctatcg gagcatcaat tggctaacta aaaagaaacc cgacacctat      540

gacttcaatg aggggactta tatcaataat gaagatgggg acataatttt cttatggggg      600

attcatcacc caccggatgc aaaagagcaa acaacactgt acaagaatgc aaatactttg      660

agtagtgtta ctaccaacac tataaacagg agcttccaac ccaatatcgg gcccaggcca      720

ctggtgagag ggcaacaagg gcggatggac tattattggg gcattttgaa gaggggagaa      780

actttaaaaa ttagaaccaa tgggaacctg atcgcgcctg aattcggtta tctgctcaaa      840

ggggagagcc atggcagaat aattcaaaat gaggacatac caattgggag ttgtcacacg      900

aaatgtcaga catacgcagg agcaattaat agcagcaaac cctttcagaa trcaagcagg      960

cactacatgg gagaatgtcc caagtatgtg aagaaggaaa gcttacggct ggcagttgga     1020

cttagaaaca ctccttctat tgaacccaga ggcttgtttg gagccattgc tggttttatt     1080

gaagggggat ggtctgggat gattgatgga tggtatgggt ttcaccatag taattcagaa     1140

ggaacaggaa tggcggccga tcagaaatcg acacaagaag caattgacaa aatcaccaat     1200

aaggtcaata atatagttga taaaatgaac agggaatttg aagtagtgaa ccatgagttt     1260

tccgaagtcg aaaaaagaat aaacatgata aatgacaaaa ttgatgacca gattgaagat     1320

ctttgggcct acaatgcaga gcttctggtc ctcctagaga accagaaaac actggatgaa     1380

cacgactcca atgtcaaaaa tctctttgat gaagtaagaa ggagactttc agccaatgca     1440

atagatactg ggaatggctg cttcgacata ctccacaaat gtgacaacga gtgcatggag     1500

accataaaga atgggactta taaccataaa gagtatgagg aagaggccaa gctggaaagg     1560

agcaagatta acggagtaaa gctagaggaa aataccacct ataaaattct cagcatttac     1620

agtacggtgg cggccagtct ttgcttggca atcctgattg ctggaggtct aatcctgggc     1680

atgcaaaatg gatcttgtag atgcatgttc tgtatttaag aaaaaacacc cttgtttcta     1740

ct                                                                    1742


<210>  32
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of influenza A/mallard/Sweden/24/2002 virus HA

<220>
<221>  misc_feature
<222>  (312)..(312)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Met Glu Lys Phe Ile Ile Met Ala Met Leu Leu Val Ser Thr Asn Ala 
1               5                   10                  15      


Tyr Asp Arg Ile Cys Ile Gly Tyr Gln Ser Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asn Thr Leu Ile Glu Gln Asn Val Pro Val Thr Gln Thr Met Glu 
        35                  40                  45              


Leu Val Glu Thr Glu Lys His Pro Ala Tyr Cys Asn Thr Asp Leu Gly 
    50                  55                  60                  


Ala Pro Leu Glu Leu Arg Asp Cys Lys Ile Glu Ala Val Ile Tyr Gly 
65                  70                  75                  80  


Asn Pro Lys Cys Asp Ile His Leu Lys Asp Gln Gly Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Arg Pro Ser Ala Pro Glu Gly Met Cys Tyr Pro Gly Ser Val 
            100                 105                 110         


Glu Asn Leu Glu Glu Leu Arg Phe Val Phe Ser Ser Ala Ala Ser Tyr 
        115                 120                 125             


Lys Arg Ile Arg Leu Phe Asp Tyr Ser Arg Trp Asn Val Thr Arg Ser 
    130                 135                 140                 


Gly Thr Ser Lys Ala Cys Asn Ala Ser Thr Gly Gly Gln Ser Phe Tyr 
145                 150                 155                 160 


Arg Ser Ile Asn Trp Leu Thr Lys Lys Lys Pro Asp Thr Tyr Asp Phe 
                165                 170                 175     


Asn Glu Gly Thr Tyr Ile Asn Asn Glu Asp Gly Asp Ile Ile Phe Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asp Ala Lys Glu Gln Thr Thr Leu Tyr 
        195                 200                 205             


Lys Asn Ala Asn Thr Leu Ser Ser Val Thr Thr Asn Thr Ile Asn Arg 
    210                 215                 220                 


Ser Phe Gln Pro Asn Ile Gly Pro Arg Pro Leu Val Arg Gly Gln Gln 
225                 230                 235                 240 


Gly Arg Met Asp Tyr Tyr Trp Gly Ile Leu Lys Arg Gly Glu Thr Leu 
                245                 250                 255     


Lys Ile Arg Thr Asn Gly Asn Leu Ile Ala Pro Glu Phe Gly Tyr Leu 
            260                 265                 270         


Leu Lys Gly Glu Ser His Gly Arg Ile Ile Gln Asn Glu Asp Ile Pro 
        275                 280                 285             


Ile Gly Ser Cys His Thr Lys Cys Gln Thr Tyr Ala Gly Ala Ile Asn 
    290                 295                 300                 


Ser Ser Lys Pro Phe Gln Asn Xaa Ser Arg His Tyr Met Gly Glu Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Lys Glu Ser Leu Arg Leu Ala Val Gly Leu Arg 
                325                 330                 335     


Asn Thr Pro Ser Ile Glu Pro Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Ser Gly Met Ile Asp Gly Trp Tyr Gly Phe 
        355                 360                 365             


His His Ser Asn Ser Glu Gly Thr Gly Met Ala Ala Asp Gln Lys Ser 
    370                 375                 380                 


Thr Gln Glu Ala Ile Asp Lys Ile Thr Asn Lys Val Asn Asn Ile Val 
385                 390                 395                 400 


Asp Lys Met Asn Arg Glu Phe Glu Val Val Asn His Glu Phe Ser Glu 
                405                 410                 415     


Val Glu Lys Arg Ile Asn Met Ile Asn Asp Lys Ile Asp Asp Gln Ile 
            420                 425                 430         


Glu Asp Leu Trp Ala Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Gln Lys Thr Leu Asp Glu His Asp Ser Asn Val Lys Asn Leu Phe Asp 
    450                 455                 460                 


Glu Val Arg Arg Arg Leu Ser Ala Asn Ala Ile Asp Thr Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Asp Ile Leu His Lys Cys Asp Asn Glu Cys Met Glu Thr Ile 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asn His Lys Glu Tyr Glu Glu Glu Ala Lys Leu 
            500                 505                 510         


Glu Arg Ser Lys Ile Asn Gly Val Lys Leu Glu Glu Asn Thr Thr Tyr 
        515                 520                 525             


Lys Ile Leu Ser Ile Tyr Ser Thr Val Ala Ala Ser Leu Cys Leu Ala 
    530                 535                 540                 


Ile Leu Ile Ala Gly Gly Leu Ile Leu Gly Met Gln Asn Gly Ser Cys 
545                 550                 555                 560 


Arg Cys Met Phe Cys Ile 
                565     


<210>  33
<211>  1840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding influenza A/Vietnam/1203/04 (HALo) virus HA

<400>  33
cggatgttgc ccagccggcg ccagcgagga ggctgggacc atgccggcca gcaaaagcag       60

gggttcaatc tgtcaaaatg gagaaaatag tgcttctttt tgcaatagtc agtcttgtta      120

aaagtgatca gatttgcatt ggttaccatg caaacaactc gacagagcag gttgacacaa      180

taatggaaaa gaacgttact gttacacatg cccaagacat actggaaaag aaacacaacg      240

ggaagctctg cgatctagat ggagtgaagc ctctaatttt gagagattgt agcgtagctg      300

gatggctcct cggaaaccca atgtgtgacg aattcatcaa tgtgccggaa tggtcttaca      360

tagtggagaa ggccaatcca gtcaatgacc tctgttaccc aggggatttc aatgactatg      420

aagaattgaa acacctattg agcagaataa accattttga gaaaattcag atcatcccca      480

aaagttcttg gtccagtcat gaagcctcat taggggtgag ctcagcatgt ccataccagg      540

gaaagtcctc ctttttcaga aatgtggtat ggcttatcaa aaagaacagt acatacccaa      600

caataaagag gagctacaat aataccaacc aagaagatct tttggtactg tgggggattc      660

accatcctaa tgatgcggca gagcagacaa agctctatca aaacccaacc acctatattt      720

ccgttgggac atcaacacta aaccagagat tggtaccaag aatagctact agatccaaag      780

taaacgggca aagtggaagg atggagttct tctggacaat tttaaagccg aatgatgcaa      840

tcaacttcga gagtaatgga aatttcattg ctccagaata tgcatacaaa attgtcaaga      900

aaggggactc aacaattatg aaaagtgaat tggaatatgg taactgcaac accaagtgtc      960

aaactccaat gggggcgata aactctagca tgccattcca caatatacac cctctcacca     1020

ttggggaatg ccccaaatat gtgaaatcaa acagattagt ccttgcgact gggctcagaa     1080

atagccctca gcgggagacg cggggattat ttggagctat agcaggtttt atagagggag     1140

gatggcaggg aatggtagat ggttggtatg ggtaccacca tagcaatgag caggggagtg     1200

ggtacgctgc agacaaagaa tccactcaaa aggcaataga tggagtcacc aataaggtca     1260

actcgatcat tgacaaaatg aacactcagt ttgaggccgt tggaagggaa tttaacaact     1320

tagaaaggag aatagagaat ttaaacaaga agatggaaga cgggttccta gatgtctgga     1380

cttataatgc tgaacttctg gttctcatgg aaaatgagag aactctagac tttcatgact     1440

caaatgtcaa gaacctttac gacaaggtcc gactacagct tagggataat gcaaaggagc     1500

tgggtaacgg ttgtttcgag ttctatcata aatgtgataa tgaatgtatg gaaagtgtaa     1560

gaaatggaac gtatgactac ccgcagtatt cagaagaagc gagactaaaa agagaggaaa     1620

taagtggagt aaaattggaa tcaataggaa tttaccaaat actgtcaatt tattctacag     1680

tggcgagttc cctagcactg gcaatcatgg tagctggtct atccttatgg atgtgctcca     1740

atgggtcgtt acaatgcaga atttgcattt aaatttgtga gttcagattg tagttaaaaa     1800

cacccttgtt tctactaata acccggcggc ccaaaatgcc                           1840


<210>  34
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa sequence of influenza A/Vietnam/1203/04 (HALo) virus HA

<400>  34

Met Glu Lys Ile Val Leu Leu Phe Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Lys His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser 
    130                 135                 140                 


Leu Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
        355                 360                 365             


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
385                 390                 395                 400 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
                405                 410                 415     


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
            420                 425                 430         


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
        435                 440                 445             


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
    450                 455                 460                 


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
            500                 505                 510         


Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Ile Tyr Gln Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met 
    530                 535                 540                 


Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys 
545                 550                 555                 560 


Arg Ile Cys Ile Ile Cys Glu Phe Arg Leu Leu Lys Thr Pro Leu Phe 
                565                 570                 575     


Leu Leu Ile Thr Arg Arg Pro Lys Met 
            580                 585 


<210>  35
<211>  1745
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding influenza A/northern 
shoveler/Netherlands/18/99 virus HA

<400>  35
aaagcagggg ttctattaag aaatcaaaat gaagaaagca ctgctatttg cagctatttt       60

cctttatgca aaggcagatg aaatctgtat cggctactta agcaacaact caacagacaa      120

agttgacaca ataatcgaga acaatgtcac agtgactagc tcagtggaac tagtcgaaac      180

agaacacact gggtcattct gctcaatcaa tggaaaacaa ccgataagtc ttggagactg      240

ctcttttgct gggtggatat taggtaatcc catgtgtgat gatctaattg gtaagacttc      300

atggtcctac attgtggaga agcccaaccc aacaaatgga atttgttacc ctggaacttt      360

ggaggatgaa gaagaactga gactgaaatt cagtggagtc ctggaattca gcaagttcga      420

agcattcaca tcaaatggat ggggtgctgt gaattcggga gcaggagtga ctgctgcatg      480

caaattcgga agctccaatt ctttcttccg aaacatggta tggcttatac atcaatcagg      540

aacatatcct gtaataaaga ggacttttaa caataccaaa ggaagagatg tgttgatcgt      600

ttggggaatt catcaccctg ccacactgaa agagcaccaa gacctataca agaaagacag      660

ttcctatgta gcagtgggtt cagaaactta caacagaaga ttcaccccag aaatcagcac      720

taggcccaaa gtcaatggac aggctggacg gatgacattt tattggacaa tggtcaaacc      780

aggagagtca ataacatttg agtctaatgg tgcattcttg gctcctagat atgcttttga      840

gattgtctct gttggaaatg ggaaattatt cagaagcgaa ctgagtattg aatcatgctc      900

taccaaatgc caaacagaag taggagggat taatacaaac aaaagtttcc acagtgttca      960

taggaacact attggagact gtcccaaata tgtgaatgtc aaatccctaa agcttgccac     1020

aggacttaga aatgttccag caatagcatc aagaggattg tttggagcaa tagccggatt     1080

tatagaaggt gggtggccag ggcttatcaa tggatggtac ggttttcaac acagaaatga     1140

ggaaggaaca ggcatagcag cagacaggga gtcaactcaa aaggcagtag accagataac     1200

atccaaagta aacaacatcg tcgacagaat gaatacaaat ttcgagtctg tgcaacacga     1260

attcagtgaa atagaggaga ggataaacca attgtcgaaa cacgtagatg attctgtggt     1320

tgacatctgg tcatataacg cacaactcct cgtttggctt gaaaatgaga aaactctgga     1380

tctccacgat tccaatgtta ggaatcttca tgagaaagtc agaaggatgc taaaggacaa     1440

tgccaaagat gagggaaatg gatgcttcac cttttaccac aagtgtgaca acgaatgcat     1500

cgaaaaggtt agaaacggaa catatgatca caaagaattc gaagaagaat caagaatcaa     1560

tcgccaggag attgagggag tgagattaga ttctagtggg aatgtgtata aaatactgtc     1620

aatttacagc tgcatcgcaa gcagtcttgt attagcagca ctcatcatgg gtttcatcct     1680

atgggcgtgc agcaatggat catgtagatg taccatttgc atttagaatt gtggcaaaaa     1740

caccc                                                                 1745


<210>  36
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of influenza A/northern 
shoveler/Netherlands/18/99 virus HA

<400>  36

Met Lys Lys Ala Leu Leu Phe Ala Ala Ile Phe Leu Tyr Ala Lys Ala 
1               5                   10                  15      


Asp Glu Ile Cys Ile Gly Tyr Leu Ser Asn Asn Ser Thr Asp Lys Val 
            20                  25                  30          


Asp Thr Ile Ile Glu Asn Asn Val Thr Val Thr Ser Ser Val Glu Leu 
        35                  40                  45              


Val Glu Thr Glu His Thr Gly Ser Phe Cys Ser Ile Asn Gly Lys Gln 
    50                  55                  60                  


Pro Ile Ser Leu Gly Asp Cys Ser Phe Ala Gly Trp Ile Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Asp Leu Ile Gly Lys Thr Ser Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Pro Asn Pro Thr Asn Gly Ile Cys Tyr Pro Gly Thr Leu Glu 
            100                 105                 110         


Asp Glu Glu Glu Leu Arg Leu Lys Phe Ser Gly Val Leu Glu Phe Ser 
        115                 120                 125             


Lys Phe Glu Ala Phe Thr Ser Asn Gly Trp Gly Ala Val Asn Ser Gly 
    130                 135                 140                 


Ala Gly Val Thr Ala Ala Cys Lys Phe Gly Ser Ser Asn Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Met Val Trp Leu Ile His Gln Ser Gly Thr Tyr Pro Val Ile 
                165                 170                 175     


Lys Arg Thr Phe Asn Asn Thr Lys Gly Arg Asp Val Leu Ile Val Trp 
            180                 185                 190         


Gly Ile His His Pro Ala Thr Leu Lys Glu His Gln Asp Leu Tyr Lys 
        195                 200                 205             


Lys Asp Ser Ser Tyr Val Ala Val Gly Ser Glu Thr Tyr Asn Arg Arg 
    210                 215                 220                 


Phe Thr Pro Glu Ile Ser Thr Arg Pro Lys Val Asn Gly Gln Ala Gly 
225                 230                 235                 240 


Arg Met Thr Phe Tyr Trp Thr Met Val Lys Pro Gly Glu Ser Ile Thr 
                245                 250                 255     


Phe Glu Ser Asn Gly Ala Phe Leu Ala Pro Arg Tyr Ala Phe Glu Ile 
            260                 265                 270         


Val Ser Val Gly Asn Gly Lys Leu Phe Arg Ser Glu Leu Ser Ile Glu 
        275                 280                 285             


Ser Cys Ser Thr Lys Cys Gln Thr Glu Val Gly Gly Ile Asn Thr Asn 
    290                 295                 300                 


Lys Ser Phe His Ser Val His Arg Asn Thr Ile Gly Asp Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Asn Val Lys Ser Leu Lys Leu Ala Thr Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Ala Ile Ala Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln His 
        355                 360                 365             


Arg Asn Glu Glu Gly Thr Gly Ile Ala Ala Asp Arg Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Val Asp Gln Ile Thr Ser Lys Val Asn Asn Ile Val Asp Arg 
385                 390                 395                 400 


Met Asn Thr Asn Phe Glu Ser Val Gln His Glu Phe Ser Glu Ile Glu 
                405                 410                 415     


Glu Arg Ile Asn Gln Leu Ser Lys His Val Asp Asp Ser Val Val Asp 
            420                 425                 430         


Ile Trp Ser Tyr Asn Ala Gln Leu Leu Val Trp Leu Glu Asn Glu Lys 
        435                 440                 445             


Thr Leu Asp Leu His Asp Ser Asn Val Arg Asn Leu His Glu Lys Val 
    450                 455                 460                 


Arg Arg Met Leu Lys Asp Asn Ala Lys Asp Glu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Thr Phe Tyr His Lys Cys Asp Asn Glu Cys Ile Glu Lys Val Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asp His Lys Glu Phe Glu Glu Glu Ser Arg Ile Asn Arg 
            500                 505                 510         


Gln Glu Ile Glu Gly Val Arg Leu Asp Ser Ser Gly Asn Val Tyr Lys 
        515                 520                 525             


Ile Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Leu Val Leu Ala Ala 
    530                 535                 540                 


Leu Ile Met Gly Phe Ile Leu Trp Ala Cys Ser Asn Gly Ser Cys Arg 
545                 550                 555                 560 


Cys Thr Ile Cys Ile 
                565 


<210>  37
<211>  1712
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding A_mallard_interior Alaska_7MP0167_2007 virus HA

<400>  37
ggtcacaatg gaaaaattca tcattttgag cactgtcctg gcagtaagct ttgcatatga       60

caaaatttgc attggatatc aaacaaacaa ctcgactgag acagtaaaca cactaatcga      120

gcaaaacgtt ccggtgacac aggtggaaga actcgtgcat ggtgggatcg atccggtcct      180

atgtggaacg gagctagggt caccattagt gcttgatgac tgttcactcg aaggtctcat      240

tctaggcaat cccaaatgtg atctttatct gaatggcagg gaatggtcat acatagtaga      300

gaggcccaaa gaaatggaag gagtttgcta cccaggatca attgaaaatc aagaggagtt      360

gagatctctg ttttcttcca tcaagaagta tgaaagagtg aagatgtttg atttcaccaa      420

atggaatgtc acgtacactg gaaccagcaa ggcctgcaac aatacatcaa accaaggctc      480

attctatagg agcatgagat ggttaacctt aaaatcagga caattcccag tccagacaga      540

tgagtacaag aacaccagag attcggacat tgtcttcacc tgggccatcc atcacccacc      600

aacatctgat gaacagataa agttatacaa aaatccggat accctctcct cagtcaccac      660

tgatgaaatc aataggagtt tcaagcctaa cataggacca aggccattag tgagaggaca      720

acaggggaga atggattact actgggctgt cctcaaacct ggacaaactg tcaaaataca      780

gaccaatggt aatcttattg cacctgaata tggtcactta attacaggga aatcacatgg      840

caggatactc aagaataact tgcccatagg acagtgtgtg actgagtgcc agttgaatga      900

aggggtgatg aatacaagta aacctttcca gaacactagt aagcactata ttgggaaatg      960

tcccaaatac ataccatcag gaagcctgaa attggcgata gggctcagaa atgttccaca     1020

agttcagaac agaggactat ttggagcaaa agcaggtttc atagagggcg gatggccagg     1080

actagtggct ggttggtatg gatttcagca tcaaaatgca gaggggacag gcatagccgc     1140

agacagagac agcactcaga aggcaataga caatatgcaa aacaaactca acaatgtcat     1200

tgacaaaatg aacaaacaat ttgaagtggt gaatcatgag ttttcagaag tggaaagcag     1260

aataaacatg attaattccc aaattgatga tcaaataact gacatatggg catacaatgc     1320

tgaactgctt gtcctattgg aaaatcagaa gacattagat gagcatgatg ctaatgtaag     1380

aaacttacac gatagagtca gaagagtcct aagagaaaat gcaattgata caggagatgg     1440

ttgctttgaa attctgcata aatgtgacaa caattgcatg gacacaatca gaaatgggac     1500

atacaatcac aaggagtatg aggaagaaag caaaatcgaa cgacagaaaa ttaatggtgt     1560

caaacttgag gagaattcta catataaaat tctgagcatc tacagcagtg ttgcctcaag     1620

cttagttcta ctgctcatga ttattggggg tttcattttc gggtgtcaaa atggaaatgt     1680

tcgttgtact ttctgtattt aattaaaaac ac                                   1712


<210>  38
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of A_mallard_interior Alaska_7MP0167_2007 virus HA

<400>  38

Met Glu Lys Phe Ile Ile Leu Ser Thr Val Leu Ala Val Ser Phe Ala 
1               5                   10                  15      


Tyr Asp Lys Ile Cys Ile Gly Tyr Gln Thr Asn Asn Ser Thr Glu Thr 
            20                  25                  30          


Val Asn Thr Leu Ile Glu Gln Asn Val Pro Val Thr Gln Val Glu Glu 
        35                  40                  45              


Leu Val His Gly Gly Ile Asp Pro Val Leu Cys Gly Thr Glu Leu Gly 
    50                  55                  60                  


Ser Pro Leu Val Leu Asp Asp Cys Ser Leu Glu Gly Leu Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Lys Cys Asp Leu Tyr Leu Asn Gly Arg Glu Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Arg Pro Lys Glu Met Glu Gly Val Cys Tyr Pro Gly Ser Ile 
            100                 105                 110         


Glu Asn Gln Glu Glu Leu Arg Ser Leu Phe Ser Ser Ile Lys Lys Tyr 
        115                 120                 125             


Glu Arg Val Lys Met Phe Asp Phe Thr Lys Trp Asn Val Thr Tyr Thr 
    130                 135                 140                 


Gly Thr Ser Lys Ala Cys Asn Asn Thr Ser Asn Gln Gly Ser Phe Tyr 
145                 150                 155                 160 


Arg Ser Met Arg Trp Leu Thr Leu Lys Ser Gly Gln Phe Pro Val Gln 
                165                 170                 175     


Thr Asp Glu Tyr Lys Asn Thr Arg Asp Ser Asp Ile Val Phe Thr Trp 
            180                 185                 190         


Ala Ile His His Pro Pro Thr Ser Asp Glu Gln Ile Lys Leu Tyr Lys 
        195                 200                 205             


Asn Pro Asp Thr Leu Ser Ser Val Thr Thr Asp Glu Ile Asn Arg Ser 
    210                 215                 220                 


Phe Lys Pro Asn Ile Gly Pro Arg Pro Leu Val Arg Gly Gln Gln Gly 
225                 230                 235                 240 


Arg Met Asp Tyr Tyr Trp Ala Val Leu Lys Pro Gly Gln Thr Val Lys 
                245                 250                 255     


Ile Gln Thr Asn Gly Asn Leu Ile Ala Pro Glu Tyr Gly His Leu Ile 
            260                 265                 270         


Thr Gly Lys Ser His Gly Arg Ile Leu Lys Asn Asn Leu Pro Ile Gly 
        275                 280                 285             


Gln Cys Val Thr Glu Cys Gln Leu Asn Glu Gly Val Met Asn Thr Ser 
    290                 295                 300                 


Lys Pro Phe Gln Asn Thr Ser Lys His Tyr Ile Gly Lys Cys Pro Lys 
305                 310                 315                 320 


Tyr Ile Pro Ser Gly Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Gln Val Gln Asn Arg Gly Leu Phe Gly Ala Lys Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His 
        355                 360                 365             


Gln Asn Ala Glu Gly Thr Gly Ile Ala Ala Asp Arg Asp Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Asn Met Gln Asn Lys Leu Asn Asn Val Ile Asp Lys 
385                 390                 395                 400 


Met Asn Lys Gln Phe Glu Val Val Asn His Glu Phe Ser Glu Val Glu 
                405                 410                 415     


Ser Arg Ile Asn Met Ile Asn Ser Gln Ile Asp Asp Gln Ile Thr Asp 
            420                 425                 430         


Ile Trp Ala Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys 
        435                 440                 445             


Thr Leu Asp Glu His Asp Ala Asn Val Arg Asn Leu His Asp Arg Val 
    450                 455                 460                 


Arg Arg Val Leu Arg Glu Asn Ala Ile Asp Thr Gly Asp Gly Cys Phe 
465                 470                 475                 480 


Glu Ile Leu His Lys Cys Asp Asn Asn Cys Met Asp Thr Ile Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asn His Lys Glu Tyr Glu Glu Glu Ser Lys Ile Glu Arg 
            500                 505                 510         


Gln Lys Ile Asn Gly Val Lys Leu Glu Glu Asn Ser Thr Tyr Lys Ile 
        515                 520                 525             


Leu Ser Ile Tyr Ser Ser Val Ala Ser Ser Leu Val Leu Leu Leu Met 
    530                 535                 540                 


Ile Ile Gly Gly Phe Ile Phe Gly Cys Gln Asn Gly Asn Val Arg Cys 
545                 550                 555                 560 


Thr Phe Cys Ile 
                


<210>  39
<211>  1775
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding influenza A/Puerto Rico/8/34 virus HA

<400>  39
agcaaaagca ggggaaaata aaaacaacca aaatgaaggc aaacctactg gtcctgttaa       60

gtgcacttgc agctgcagat gcagacacaa tatgtatagg ctaccatgcg aacaattcaa      120

ccgacactgt tgacacagta ctcgagaaga atgtgacagt gacacactct gttaacctgc      180

tcgaagacag ccacaacgga aaactatgta gattaaaagg aatagcccca ctacaattgg      240

ggaaatgtaa catcgccgga tggctcttgg gaaacccaga atgcgaccca ctgcttccag      300

tgagatcatg gtcctacatt gtagaaacac caaactctga gaatggaata tgttatccag      360

gagatttcat cgactatgag gagctgaggg agcaattgag ctcagtgtca tcattcgaaa      420

gattcgaaat atttcccaaa gaaagctcat ggcccaacca caacacaaac ggagtaacgg      480

cagcatgctc ccatgagggg aaaagcagtt tttacagaaa tttgctatgg ctgacggaga      540

aggagggctc atacccaaag ctgaaaaatt cttatgtgaa caaaaaaggg aaagaagtcc      600

ttgtactgtg gggtattcat cacccgccta acagtaagga acaacagaat atctatcaga      660

atgaaaatgc ttatgtctct gtagtgactt caaattataa caggagattt accccggaaa      720

tagcagaaag acccaaagta agagatcaag ctgggaggat gaactattac tggaccttgc      780

taaaacccgg agacacaata atatttgagg caaatggaaa tctaatagca ccaatgtatg      840

ctttcgcact gagtagaggc tttgggtccg gcatcatcac ctcaaacgca tcaatgcatg      900

agtgtaacac gaagtgtcaa acacccctgg gagctataaa cagcagtctc ccttaccaga      960

atatacaccc agtcacaata ggagagtgcc caaaatacgt caggagtgcc aaattgagga     1020

tggttacagg actaaggaac actccgtcca ttcaatccag aggtctattt ggagccattg     1080

ccggttttat tgaaggggga tggactggaa tgatagatgg atggtatggt tatcatcatc     1140

agaatgaaca gggatcaggc tatgcagcgg atcaaaaaag cacacaaaat gccattaacg     1200

ggattacaaa caaggtgaac actgttatcg agaaaatgaa cattcaattc acagctgtgg     1260

gtaaagaatt caacaaatta gaaaaaagga tggaaaattt aaataaaaaa gttgatgatg     1320

gatttctgga catttggaca tataatgcag aattgttagt tctactggaa aatgaaagga     1380

ctctggattt ccatgactca aatgtgaaga atctgtatga gaaagtaaaa agccaattaa     1440

agaataatgc caaagaaatc ggaaatggat gttttgagtt ctaccacaag tgtgacaatg     1500

aatgcatgga aagtgtaaga aatgggactt atgattatcc caaatattca gaagagtcaa     1560

agttgaacag ggaaaaggta gatggagtga aattggaatc aatggggatc tatcagattc     1620

tggcgatcta ctcaactgtc gccagttcac tggtgctttt ggtctccctg ggggcaatca     1680

gtttctggat gtgttctaat ggatctttgc agtgcagaat atgcatctga gattagaatt     1740

tcagaaatat gaggaaaaac acccttgttt ctact                                1775


<210>  40
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of influenza A/Puerto Rico/8/34 virus HA

<400>  40

Met Lys Ala Asn Leu Leu Val Leu Leu Ser Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Ile Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Thr Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


<210>  41
<211>  1879
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding influenza B/Yamagata/16/88 virus HA

<400>  41
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

accatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaaatatca gattatcaac ccataacgtt atcaacgcag aaagggcacc aggaggaccc      480

tacagacttg gaacctcaga atcttgccct aacgttacca gtagaaacgg attcttcgca      540

acaatggctt gggctgtccc aagggacaac aaaacagcaa cgaatccact aacagtagaa      600

gtaccataca tttgcacaaa aggagaagac caaattactg tttgggggtt ccattctgat      660

aacaaaaacc aaatgaaaaa cctctatgga gactcaaatc ctcaaaagtt cacctcatct      720

gccaatggag taaccacaca ttatgtttct cagattggtg acttcccaaa tcaaacagaa      780

gacggagggc taccacaaag cggcagaatt gttgttgatt acatggtgca aaaacctggg      840

aaaacaggaa caattgtcta tcaaagaggt gttttgttgc ctcaaaaggt gtggtgcgca      900

agtggcagga gcaaggtaat aaaagggtcc ttgcctttaa ttggtgaagc agattgcctt      960

cacgaaaaat acggtggatt aaacaaaagc aagccttact acacaggaga acatgcaaaa     1020

gccataggaa attgcccaat atgggtgaaa acacctttga agcttgccaa tggaaccaaa     1080

tatagacctc ctgcaaaact attaaaggaa aggggtttct tcggagctat tgctggtttc     1140

ttagagggag gatgggaagg aatgattgca ggttggcacg gatacacatc tcatggagca     1200

catggagtgg cagtggcagc agaccttaag agcacgcaag aagccataaa caagataaca     1260

aaaaatctca attctttgag tgagctagaa gtaaagaatc ttcaaagact aagtggtgcc     1320

atggatgaac tccacaacga aatactcgag ctggatgaga aagtggatga tctcagagct     1380

gacacaataa gctcgcaaat agagcttgca gtcttgcttt ccaacgaagg aataataaac     1440

agtgaagatg agcatctatt ggcacttgag agaaaactaa agaaaatgct gggtccctct     1500

gctgtagaca tagggaatgg atgcttcgaa accaaacaca agtgcaacca gacctgctta     1560

gacaggatag ctgctggcac ctttaatgca ggagaatttt ctcttcccac ttttgattca     1620

ctgaatatta ctgctgcatc tttaaatgat gatggattgg ataatcatac tatactgctc     1680

tactactcaa ctgctgcttc tagtttggcc gtaacattga tgatagctat ttttattgtt     1740

tatatggtct ccagagacaa tgtttcttgc tccatctgtc tataaggaaa attaagccct     1800

gtattttcct ttattgtagt gcttgtttgc ttgttaccat tacaaagaaa cgttattgaa     1860

aaatgctctt gttactact                                                  1879


<210>  42
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of influenza B/Yamagata/16/88 virus HA

<400>  42

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Thr Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Arg 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Glu Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Ser Arg Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Arg Asp Asn Lys Thr Ala Thr Asn Pro Leu Thr Val Glu Val Pro Tyr 
            180                 185                 190         


Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser 
        195                 200                 205             


Asp Asn Lys Asn Gln Met Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln 
    210                 215                 220                 


Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln 
225                 230                 235                 240 


Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser 
                245                 250                 255     


Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly 
            260                 265                 270         


Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys 
        275                 280                 285             


Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly 
    290                 295                 300                 


Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys 
305                 310                 315                 320 


Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile 
                325                 330                 335     


Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro 
            340                 345                 350         


Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
        355                 360                 365             


Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
    370                 375                 380                 


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
385                 390                 395                 400 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
                405                 410                 415     


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
            420                 425                 430         


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
        435                 440                 445             


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
    450                 455                 460                 


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
465                 470                 475                 480 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
                485                 490                 495     


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
            500                 505                 510         


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
        515                 520                 525             


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
    530                 535                 540                 


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
545                 550                 555                 560 


Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn 
                565                 570                 575     


Val Ser Cys Ser Ile Cys Leu 
            580             


<210>  43
<211>  1876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding mH5/B chimeric HA for rescue in B/Yamagata/16/88

<400>  43
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

ttcatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaaaaatcc agttatcaac caaaaacgtt atcaacgcag aacatgcacc aggaggaccc      480

tacagacttg gaacctcaaa atcttgccca taccagggaa agtcctcctt cttcgcaaca      540

atggcttggg ctgtcccaaa aaagaacagt acatacacga atccactaac agtagaagta      600

ccatacattt gcacaaaagg agaagaccaa attactgttt gggggttcca ttctgataat      660

gatgcggcaa tgcagacact ctatggagac tcaaatcctc aaaagttcac ctcatctgcc      720

aatggagtaa ccacacatta tgtttctcag attggtgact tcccaaatca aacagaagac      780

ggagggctac cacaaagcgg cagaattgtt gttgattaca tggtgcaaaa acctgggaaa      840

acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc aaaaggtgtg gtgcgcaagt      900

ggcaggagca aggtaataaa agggtccttg cctttaattg gtgaagcaga ttgccttcac      960

gaaaaatacg gtggattaaa caaaagcaag ccttactaca caggagaaca tgcaaaagcc     1020

ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc ttgccaatgg aaccaaatat     1080

agacctcctg caaaactatt aaaggaaagg ggtttcttcg gagctattgc tggtttctta     1140

gagggaggat gggaaggaat gattgcaggt tggcacggat acacatctca tggagcacat     1200

ggagtggcag tggcagcaga ccttaagagc acgcaagaag ccataaacaa gataacaaaa     1260

aatctcaatt ctttgagtga gctagaagta aagaatcttc aaagactaag tggtgccatg     1320

gatgaactcc acaacgaaat actcgagctg gatgagaaag tggatgatct cagagctgac     1380

acaataagct cgcaaataga gcttgcagtc ttgctttcca acgaaggaat aataaacagt     1440

gaagatgagc atctattggc acttgagaga aaactaaaga aaatgctggg tccctctgct     1500

gtagacatag ggaatggatg cttcgaaacc aaacacaagt gcaaccagac ctgcttagac     1560

aggatagctg ctggcacctt taatgcagga gaattttctc ttcccacttt tgattcactg     1620

aatattactg ctgcatcttt aaatgatgat ggattggata atcatactat actgctctac     1680

tactcaactg ctgcttctag tttggccgta acattgatga tagctatttt tattgtttat     1740

atggtctcca gagacaatgt ttcttgctcc atctgtctat aaggaaaatt aagccctgta     1800

ttttccttta ttgtagtgct tgtttgcttg ttaccattac aaagaaacgt tattgaaaaa     1860

tgctcttgtt actact                                                     1876


<210>  44
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of mH5/B chimeric HA for rescue in B/Yamagata/16/88

<400>  44

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Phe Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Lys Ile Gln Leu Ser Thr Lys Asn Val Ile Asn Ala Glu His 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Lys Ser Cys Pro Tyr 
145                 150                 155                 160 


Gln Gly Lys Ser Ser Phe Phe Ala Thr Met Ala Trp Ala Val Pro Lys 
                165                 170                 175     


Lys Asn Ser Thr Tyr Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Asn Asp Ala Ala Met Gln Thr Leu Tyr Gly Asp Ser Asn Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  45
<211>  1882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding mH8/B chimeric HA for rescue in B/Yamagata/16/88

<400>  45
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

cacatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaaggatca gattatcaac ctacaacgtt atcaacgcag aaaccgcacc aggaggaccc      480

tacagacttg gaacctcaaa atcttgcaat gcttcaacag gaggccaatc tttcttcgca      540

acaatggctt gggctgtccc aaaaaagaaa gcagacacct atacgaatcc actaacagta      600

gaagtaccat acatttgcac aaaaggagaa gaccaaatta ctgtttgggg gttccattct      660

gatgcagatg caaaaatgca aacactctat ggagactcaa atcctcaaaa gttcacctca      720

tctgccaatg gagtaaccac acattatgtt tctcagattg gtgacttccc aaatcaaaca      780

gaagacggag ggctaccaca aagcggcaga attgttgttg attacatggt gcaaaaacct      840

gggaaaacag gaacaattgt ctatcaaaga ggtgttttgt tgcctcaaaa ggtgtggtgc      900

gcaagtggca ggagcaaggt aataaaaggg tccttgcctt taattggtga agcagattgc      960

cttcacgaaa aatacggtgg attaaacaaa agcaagcctt actacacagg agaacatgca     1020

aaagccatag gaaattgccc aatatgggtg aaaacacctt tgaagcttgc caatggaacc     1080

aaatatagac ctcctgcaaa actattaaag gaaaggggtt tcttcggagc tattgctggt     1140

ttcttagagg gaggatggga aggaatgatt gcaggttggc acggatacac atctcatgga     1200

gcacatggag tggcagtggc agcagacctt aagagcacgc aagaagccat aaacaagata     1260

acaaaaaatc tcaattcttt gagtgagcta gaagtaaaga atcttcaaag actaagtggt     1320

gccatggatg aactccacaa cgaaatactc gagctggatg agaaagtgga tgatctcaga     1380

gctgacacaa taagctcgca aatagagctt gcagtcttgc tttccaacga aggaataata     1440

aacagtgaag atgagcatct attggcactt gagagaaaac taaagaaaat gctgggtccc     1500

tctgctgtag acatagggaa tggatgcttc gaaaccaaac acaagtgcaa ccagacctgc     1560

ttagacagga tagctgctgg cacctttaat gcaggagaat tttctcttcc cacttttgat     1620

tcactgaata ttactgctgc atctttaaat gatgatggat tggataatca tactatactg     1680

ctctactact caactgctgc ttctagtttg gccgtaacat tgatgatagc tatttttatt     1740

gtttatatgg tctccagaga caatgtttct tgctccatct gtctataagg aaaattaagc     1800

cctgtatttt cctttattgt agtgcttgtt tgcttgttac cattacaaag aaacgttatt     1860

gaaaaatgct cttgttacta ct                                              1882


<210>  46
<211>  584
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of mH8/B chimeric HA for rescue in B/Yamagata/16/88

<400>  46

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly His Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Arg Ile Arg Leu Ser Thr Tyr Asn Val Ile Asn Ala Glu Thr 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Lys Ser Cys Asn Ala 
145                 150                 155                 160 


Ser Thr Gly Gly Gln Ser Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Lys Lys Ala Asp Thr Tyr Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Ala Asp Ala Lys Met Gln Thr Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
        355                 360                 365             


Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly 
    370                 375                 380                 


Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys 
385                 390                 395                 400 


Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu 
                405                 410                 415     


Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp 
            420                 425                 430         


Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu 
        435                 440                 445             


Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser 
    450                 455                 460                 


Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu 
465                 470                 475                 480 


Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn 
                485                 490                 495     


Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg 
            500                 505                 510         


Ile Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe 
        515                 520                 525             


Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp 
    530                 535                 540                 


Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala 
545                 550                 555                 560 


Val Thr Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp 
                565                 570                 575     


Asn Val Ser Cys Ser Ile Cys Leu 
            580                 


<210>  47
<211>  1972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding mH11/B chimeric HA for rescue in B/Yamagata/16/88

<400>  47
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

ctaatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaaagatcg aattatcaac ctcaaacgtt atcaacgcag aagtggcacc aggaggaccc      480

tacagacttg gaacctcaga atcttgccct ttcggaagct ccaattcttt cttcgcaaca      540

atggcttggg ctgtcccaca tcaatcagga acatatacga atccactaac agtagaagta      600

ccatacattt gcacaaaagg agaagaccaa attactgttt gggggttcca ttctgatacc      660

acactgaaaa tgcaccaact ctatggagac tcaaatcctc aaaagttcac ctcatctgcc      720

aatggagtaa ccacacatta tgtttctcag attggtgact tcccaaatca aacagaagac      780

gaagggctac cacaaagcgg cagaattgtt gttgattaca tggtgcaaaa acctgggaaa      840

acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc aaaaggtgtg gtgcgcaagt      900

ggcaggagca aggtaataaa agggtccttg cctttaattg gtgaagcaga ttgccttcac      960

gaaaaatacg gtggattaaa caaaagcaag ccttactaca caggagaaca tgcaaaagcc     1020

ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc ttgccaatgg aaccaaatat     1080

agacctcctg caaaactatt aaaggaaagg ggtttcttcg gagctattgc tggtttctta     1140

gagggaggat gggaaggaat gattgcaggt tggcacggat acacatctca tggagcacat     1200

ggagtggcag tggcagcaga ccttaagagc acgcaagaag ccataaacaa gataacaaaa     1260

aatctcaatt ctttgagtga gctagaagta aagaatcttc aaagactaag tggtgccatg     1320

gatgaactcc acaacgaaat actcgagctg gatgagaaag tggatgatct cagagctgac     1380

acaataagct cgcaaataga gcttgcagtc ttgctttcca acgaaggaat aataaacagt     1440

gaagatgagc atctattggc acttgagaga aaactaaaga aaatgctggg tccctctgct     1500

gtagacatag ggaatggatg cttcgaaacc aaacacaagt gcaaccagac ctgcttagac     1560

aggatagctg ctggcacctt taatgcagga gaattttctc ttcccacttt tgattcactg     1620

aatattactg ctgcatcttt aaatgatgat ggattggata atcatactat actgctctac     1680

tactcaactg ctgcttctag tttggccgta acattgatga tagctatttt tattgtttat     1740

atggtctcca gagacaatgt ttcttgctcc atctgtctat aaggaaaatt aagccctgta     1800

ttttccttta ttgtagtgct tgtttgcttg ttaccattac aaagaaacgt tattgaaaaa     1860

tgctcttgtt tactactagg aaaattaagc cctgtatttt cctttattgt agtgcttgtt     1920

tgcttgttac cattacaaag aaacgttatt gaaaaatgct cttgttacta ct             1972


<210>  48
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of mH11/B chimeric HA for rescue in B/Yamagata/16/88

<400>  48

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Leu Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Lys Ile Glu Leu Ser Thr Ser Asn Val Ile Asn Ala Glu Val 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Glu Ser Cys Pro Phe 
145                 150                 155                 160 


Gly Ser Ser Asn Ser Phe Phe Ala Thr Met Ala Trp Ala Val Pro His 
                165                 170                 175     


Gln Ser Gly Thr Tyr Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Thr Thr Leu Lys Met His Gln Leu Tyr Gly Asp Ser Asn Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Asp Phe Pro Asn Gln Thr Glu Asp Glu Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  49
<211>  1870
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding mH13/B chimeric HA for rescue in B/Yamagata/16/88

<400>  49
agcagaagca gagcattttc taatatccac aaaatgaagg caataattgt actactcatg       60

gtagtaacat ccaacgcaga tcgaatctgc actgggataa catcttcaaa ctcacctcat      120

gtggtcaaaa cagctactca aggggaagtt aatgtgactg gtgtgatacc actgacaaca      180

acaccaacaa aatctcattt tgcaaatctc aaaggaacaa agaccagagg gaaactatgc      240

ccaaactgtc tcaactgcac agatctggat gtggccttgg gcagaccaat gtgtatgggg      300

aacatacctt cggcaaaagc ttcaatactc cacgaagtca gacctgttac atccgggtgc      360

tttcctataa tgcacgacag aacaaaaatc agacagctac ccaatcttct cagaggatat      420

gaaagaatcg agttatcaac ccataacgtt atcaacgcag aagtggcacc aggaggaccc      480

tacagacttg gaacctcaaa atcttgccca gataaaggag ccagcagctt cttcgcaaca      540

atggcttggg ctgtcccaaa gagaggaaat cagtatacga atccactaac agtagaagta      600

ccatacattt gcacaaaagg agaagaccaa attactgttt gggggttcca ttctgatgtt      660

tccacaaaca tggcgaaact ctatggagac tcaaatcctc aaaagttcac ctcatctgcc      720

aatggagtaa ccacacatta tgtttctcag attggtgact tcccaaatca aacagaagac      780

ggagggctac cacaaagcgg cagaattgtt gttgattaca tggtgcaaaa acctgggaaa      840

acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc aaaaggtgtg gtgcgcaagt      900

ggcaggagca aggtaataaa agggtccttg cctttaattg gtgaagcaga ttgccttcac      960

gaaaaatacg gtggattaaa caaaagcaag ccttactaca caggagaaca tgcaaaagcc     1020

ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc ttgccaatgg aaccaaatat     1080

agacctcctg caaaactatt aaaggaaagg ggtttcttcg gagctattgc tggtttctta     1140

gagggaggat gggaaggaat gattgcaggt tggcacggat acacatctca tggagcacat     1200

ggagtggcag tggcagcaga ccttaagagc acgcaagaag ccataaacaa gataacaaaa     1260

aatctcaatt ctttgagtga gctagaagta aagaatcttc aaagactaag tggtgccatg     1320

gatgaactcc acaacgaaat actcgagctg gatgagaaag tggatgatct cagagctgac     1380

acaataagct cgcaaataga gcttgcagtc ttgctttcca acgaaggaat aataaacagt     1440

gaagatgagc atctattggc acttgagaga aaactaaaga aaatgctggg tccctctgct     1500

gtagacatag ggaatggatg cttcgaaacc aaacacaagt gcaaccagac ctgcttagac     1560

aggatagctg ctggcacctt taatgcagga gaattttctc ttcccacttt tgattcactg     1620

aatattactg ctgcatcttt aaatgatgat ggattggata atcatactat actgctctac     1680

tactcaactg ctgcttctag tttggccgta acattgatga tagctatttt tattgtttat     1740

atggtctcca gagacaatgt ttcttgctcc atctgtctat aaggaaaatt aagccctgta     1800

ttttccttta ttgtagtgct tgtttgcttg ttaccattac aaagaaacgt tattgaaaaa     1860

tgctcttgtt                                                            1870


<210>  50
<211>  582
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of mH13/B chimeric HA for rescue in amino acids from 
B/Yamagata/16/88

<400>  50

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Lys Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asn Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Met Gly Asn Ile Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Arg Ile Glu Leu Ser Thr His Asn Val Ile Asn Ala Glu Val 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Lys Ser Cys Pro Asp 
145                 150                 155                 160 


Lys Gly Ala Ser Ser Phe Phe Ala Thr Met Ala Trp Ala Val Pro Lys 
                165                 170                 175     


Arg Gly Asn Gln Tyr Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile 
            180                 185                 190         


Cys Thr Lys Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp 
        195                 200                 205             


Val Ser Thr Asn Met Ala Lys Leu Tyr Gly Asp Ser Asn Pro Gln Lys 
    210                 215                 220                 


Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile 
225                 230                 235                 240 


Gly Asp Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly 
                245                 250                 255     


Arg Ile Val Val Asp Tyr Met Val Gln Lys Pro Gly Lys Thr Gly Thr 
            260                 265                 270         


Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala 
        275                 280                 285             


Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
    290                 295                 300                 


Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
305                 310                 315                 320 


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
                325                 330                 335     


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
            340                 345                 350         


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
        355                 360                 365             


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
    370                 375                 380                 


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
385                 390                 395                 400 


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
                405                 410                 415     


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
            420                 425                 430         


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
        435                 440                 445             


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
    450                 455                 460                 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
465                 470                 475                 480 


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly Cys 
                485                 490                 495     


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
            500                 505                 510         


Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
        515                 520                 525             


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
    530                 535                 540                 


Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr 
545                 550                 555                 560 


Leu Met Ile Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn Val 
                565                 570                 575     


Ser Cys Ser Ile Cys Leu 
            580         


<210>  51
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with 
amino acids from A/Mallard/Sweden/24/2002 virus (H8)

<400>  51

Arg Ile Arg Leu Ser Thr Tyr Asn Val Ile Asn Ala Glu Thr Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with 
amino acids from A/Mallard/Sweden/24/2002 virus (H8)

<400>  52

Asn Ala Ser Thr Gly Gly Gln Ser 
1               5               


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with 
amino acids from A/Mallard/Sweden/24/2002 virus (H8)

<400>  53

Lys Lys Lys Ala Asp Thr Tyr 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with 
amino acids from A/Mallard/Sweden/24/2002 virus (H8)

<400>  54

Ala Asp Ala Lys Met Gln Thr 
1               5           


<210>  55
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with 
amino acids from A/northern shoveler/Netherlands/18/99 

<400>  55

Lys Ile Glu Leu Ser Thr Ser Asn Val Ile Asn Ala Glu Val Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with 
amino acids from A/northern shoveler/Netherlands/18/99 

<400>  56

Pro Phe Gly Ser Ser Asn Ser 
1               5           


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with 
amino acids from A/northern shoveler/Netherlands/18/99 

<400>  57

His Gln Ser Gly Thr Tyr 
1               5       


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with 
amino acids from A/northern shoveler/Netherlands/18/99 

<400>  58

Thr Thr Leu Lys Met His Gln 
1               5           


<210>  59
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with 
amino acids from A/black headed gull/Sweden/1/99

<400>  59

Arg Ile Glu Leu Ser Thr His Asn Val Ile Asn Ala Glu Val Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with 
amino acids from A/black headed gull/Sweden/1/99

<400>  60

Pro Asp Lys Gly Ala Ser Ser 
1               5           


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with 
amino acids from A/black headed gull/Sweden/1/99

<400>  61

Lys Arg Gly Asn Gln Tyr 
1               5       


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with 
amino acids from A/black headed gull/Sweden/1/99

<400>  62

Val Ser Thr Asn Met Ala Lys 
1               5           


<210>  63
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 120 loop substituted with 
amino acids from A/mallard/interior Alaska/7MP0167/2007

<400>  63

Arg Ile Lys Leu Ser Thr Phe Asn Val Ile Asn Ala Glu Thr Ala Pro 
1               5                   10                  15      


Gly Gly Pro Tyr Arg Leu 
            20          


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with 
amino acids from A/mallard/interior Alaska/7MP0167/2007

<400>  64

Asn Asn Thr Ser Asn Gln Gly Ser 
1               5               


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with 
amino acids from A/mallard/interior Alaska/7MP0167/2007

<400>  65

Leu Lys Ser Gly Gln Phe 
1               5       


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with 
amino acids from A/mallard/interior Alaska/7MP0167/2007

<400>  66

Pro Thr Ser Asp Met Gln Ile 
1               5           


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 150 loop substituted with 
amino acids from A/northern shoveler/Netherlands/18/99 

<400>  67

Lys Phe Gly Ser Ser Asn Ser 
1               5           


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 160 loop substituted with 
amino acids from A/mallard/Sweden/24/2002 

<400>  68

Lys Lys Lys Pro Asp Thr Tyr 
1               5           


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with 
amino acids from A/mallard/Sweden/24/2002 

<400>  69

Pro Asp Ala Lys Met Gln Thr 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary B/Yamagata/16/88 190 helix substituted with 
amino acids from A/northern shoveler/Netherlands/18/99 

<400>  70

Ala Thr Leu Lys Met His Gln 
1               5           


<210>  71
<211>  1765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding influenza A/black headed 
gull/Sweden/1/99 virus HA

<400>  71
agcaaaagca ggggaaaatt tcaacaaact gatacaagag aaatggacat cccagtagtc       60

gcattcttga tattaaccag tacatgcgta caggctgata ggatatgtgt tgggtactta      120

agcaccaact catcagaaaa ggttgacaca ctgttagaaa acgatgttcc ggttacaagc      180

tctgttgatc tggttgagac taaccacaca ggaacatatt gttctttggg tggaatcagt      240

ccggtgcacc tgggagactg tagcttcgag ggctggattg tagggaaccc tgcctgtgcc      300

agcaacctgg ggatcagaga atggtcatac ttgattgaag atccttctgc tcctcatgga      360

ttgtgctacc caggggagtt agacaacaat ggagaattga ggcacttgtt cagtggaatc      420

agatctttca gtagaacaga gttgattgca cctacttctt ggggggcagt gaatgatgga      480

gtatcgtcgg cctgtccaga taaaggagcc agcagctttt accggaactt ggtatggttt      540

gtgaagagag gaaatcagta tcctgtaatc cgcgggacct acaacaacac tactggcaga      600

gatgttttgg ttatatgggg tatacatcac cctgtttcca cagacgaagc gaaacaacta      660

tatgtcaata acaacccata cacgttggta tctaccagtt catggagtag gaaatacaac      720

ttagagactg gaacccggcc tggatacaat ggccaaaaga gttggatgaa gatttactgg      780

tatttgatgc acccagggga gtcaatcagt ttcgaaagca atggaggatt attggcaccc      840

agatatggtt atattattga ggaatatgga aaagggcgaa ttttccaaag ccgcattcga      900

attgctaaat gcaatactaa gtgccaaaca tctgtcggtg ggataaatac caacaaaaca      960

tttcaaaaca tagagagaaa tgcacttggg gattgcccga aatacataaa atctggacag     1020

ctcaagttag ccaccggact taggaatgta cctgccatat caaacagagg gttgttcggg     1080

gctattgcag gcttcataga aggtggttgg ccaggattaa taaatggttg gtatggattc     1140

caacatcaga acgaacaagg agtgggcatg gctgcagaca aagagtcaac acaaaaggct     1200

attgatcaaa taacaaccaa gataaacaat atcattgaaa aaatgaatgg gaattatgac     1260

tccatacgag gtgaattcaa tcaggtggaa caaagaataa atatgcttgc agacagaata     1320

gatgatgctg taactgatgt atggtcatac aatgcaaagc ttcttgtgtt actagagaac     1380

gataaaactc tagacatgca tgatgctaat gttagaaacc tgcatgatca agtccgtaga     1440

gcactaaaga ccaatgcaat tgatgaggga aatggatgtt tcgaactcct ccataaatgc     1500

aatgactctt gcatggagac aataagaaat ggaacgtaca atcatacaga atatgaggaa     1560

gaatccaaat taaagagaca ggaaatagaa ggaataaagc tgaagtcaga cgatagtgtt     1620

tataaagcac tatcgattta cagctgcatt gcaagcagta ttgtattggt aggactcata     1680

cttacattca tcatgtgggc atgcagcagt ggcaattgcc ggttcaatat ttgtatataa     1740

gtagaaaaaa cacccttgtt ctact                                           1765


<210>  72
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of influenza A/black headed gull/Sweden/1/99 virus HA

<400>  72

Met Asp Ile Pro Val Val Ala Phe Leu Ile Leu Thr Ser Thr Cys Val 
1               5                   10                  15      


Gln Ala Asp Arg Ile Cys Val Gly Tyr Leu Ser Thr Asn Ser Ser Glu 
            20                  25                  30          


Lys Val Asp Thr Leu Leu Glu Asn Asp Val Pro Val Thr Ser Ser Val 
        35                  40                  45              


Asp Leu Val Glu Thr Asn His Thr Gly Thr Tyr Cys Ser Leu Gly Gly 
    50                  55                  60                  


Ile Ser Pro Val His Leu Gly Asp Cys Ser Phe Glu Gly Trp Ile Val 
65                  70                  75                  80  


Gly Asn Pro Ala Cys Ala Ser Asn Leu Gly Ile Arg Glu Trp Ser Tyr 
                85                  90                  95      


Leu Ile Glu Asp Pro Ser Ala Pro His Gly Leu Cys Tyr Pro Gly Glu 
            100                 105                 110         


Leu Asp Asn Asn Gly Glu Leu Arg His Leu Phe Ser Gly Ile Arg Ser 
        115                 120                 125             


Phe Ser Arg Thr Glu Leu Ile Ala Pro Thr Ser Trp Gly Ala Val Asn 
    130                 135                 140                 


Asp Gly Val Ser Ser Ala Cys Pro Asp Lys Gly Ala Ser Ser Phe Tyr 
145                 150                 155                 160 


Arg Asn Leu Val Trp Phe Val Lys Arg Gly Asn Gln Tyr Pro Val Ile 
                165                 170                 175     


Arg Gly Thr Tyr Asn Asn Thr Thr Gly Arg Asp Val Leu Val Ile Trp 
            180                 185                 190         


Gly Ile His His Pro Val Ser Thr Asp Glu Ala Lys Gln Leu Tyr Val 
        195                 200                 205             


Asn Asn Asn Pro Tyr Thr Leu Val Ser Thr Ser Ser Trp Ser Arg Lys 
    210                 215                 220                 


Tyr Asn Leu Glu Thr Gly Thr Arg Pro Gly Tyr Asn Gly Gln Lys Ser 
225                 230                 235                 240 


Trp Met Lys Ile Tyr Trp Tyr Leu Met His Pro Gly Glu Ser Ile Ser 
                245                 250                 255     


Phe Glu Ser Asn Gly Gly Leu Leu Ala Pro Arg Tyr Gly Tyr Ile Ile 
            260                 265                 270         


Glu Glu Tyr Gly Lys Gly Arg Ile Phe Gln Ser Arg Ile Arg Ile Ala 
        275                 280                 285             


Lys Cys Asn Thr Lys Cys Gln Thr Ser Val Gly Gly Ile Asn Thr Asn 
    290                 295                 300                 


Lys Thr Phe Gln Asn Ile Glu Arg Asn Ala Leu Gly Asp Cys Pro Lys 
305                 310                 315                 320 


Tyr Ile Lys Ser Gly Gln Leu Lys Leu Ala Thr Gly Leu Arg Asn Val 
                325                 330                 335     


Pro Ala Ile Ser Asn Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
            340                 345                 350         


Glu Gly Gly Trp Pro Gly Leu Ile Asn Gly Trp Tyr Gly Phe Gln His 
        355                 360                 365             


Gln Asn Glu Gln Gly Val Gly Met Ala Ala Asp Lys Glu Ser Thr Gln 
    370                 375                 380                 


Lys Ala Ile Asp Gln Ile Thr Thr Lys Ile Asn Asn Ile Ile Glu Lys 
385                 390                 395                 400 


Met Asn Gly Asn Tyr Asp Ser Ile Arg Gly Glu Phe Asn Gln Val Glu 
                405                 410                 415     


Gln Arg Ile Asn Met Leu Ala Asp Arg Ile Asp Asp Ala Val Thr Asp 
            420                 425                 430         


Val Trp Ser Tyr Asn Ala Lys Leu Leu Val Leu Leu Glu Asn Asp Lys 
        435                 440                 445             


Thr Leu Asp Met His Asp Ala Asn Val Arg Asn Leu His Asp Gln Val 
    450                 455                 460                 


Arg Arg Ala Leu Lys Thr Asn Ala Ile Asp Glu Gly Asn Gly Cys Phe 
465                 470                 475                 480 


Glu Leu Leu His Lys Cys Asn Asp Ser Cys Met Glu Thr Ile Arg Asn 
                485                 490                 495     


Gly Thr Tyr Asn His Thr Glu Tyr Glu Glu Glu Ser Lys Leu Lys Arg 
            500                 505                 510         


Gln Glu Ile Glu Gly Ile Lys Leu Lys Ser Asp Asp Ser Val Tyr Lys 
        515                 520                 525             


Ala Leu Ser Ile Tyr Ser Cys Ile Ala Ser Ser Ile Val Leu Val Gly 
    530                 535                 540                 


Leu Ile Leu Thr Phe Ile Met Trp Ala Cys Ser Ser Gly Asn Cys Arg 
545                 550                 555                 560 


Phe Asn Ile Cys Ile 
                565 


<210>  73
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus HA

<220>
<221>  misc_feature
<222>  (212)..(212)
<223>  Xaa = Asn or Ser

<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa = Asn, Ile, Thr or Ser

<400>  73

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Xaa Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide of mouse adapted Influenza 
B/Malaysia/2506/2004 virus HA

<400>  74

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala 
1               5                   10                  15  


<210>  75
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA1 of mouse adapted Influenza B/Malaysia/2506/2004 virus HA

<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  Xaa = Asn or Ser

<220>
<221>  misc_feature
<222>  (199)..(199)
<223>  Xaa = Asn, Ile, Thr or Ser

<400>  75

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg 
65                  70                  75                  80  


Val Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu 
                165                 170                 175     


Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly 
            180                 185                 190         


Phe His Ser Asp Xaa Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser 
        195                 200                 205             


Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr 
    210                 215                 220                 


Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu 
225                 230                 235                 240 


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly 
                245                 250                 255     


Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys 
            260                 265                 270         


Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro 
        275                 280                 285             


Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
    290                 295                 300                 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
305                 310                 315                 320 


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
                325                 330                 335     


Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg 
            340                 345         



<210>  76
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA2 of mouse adapted Influenza B/Malaysia/2506/2004 virus HA

<400>  76

Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly Val 
            20                  25                  30          


Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile 
        35                  40                  45              


Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln 
    50                  55                  60                  


Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile 
                85                  90                  95      


Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp 
            100                 105                 110         


Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro 
        115                 120                 125             


Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys 
    130                 135                 140                 


Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly 
145                 150                 155                 160 


Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser 
                165                 170                 175     


Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser 
            180                 185                 190         


Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala Ile Phe Val 
        195                 200                 205             


Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
    210                 215                 220             


<210>  77
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Head Sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus HA

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  Xaa = Asn or Ser

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa = Asn, Ile, Thr or Ser

<400>  77

Asn Leu Lys Gly Thr Glu Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu 
1               5                   10                  15      


Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys Thr Gly 
            20                  25                  30          


Asn Ile Pro Ser Ala Arg Val Ser Ile Leu His Glu Val Arg Pro Val 
        35                  40                  45              


Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln 
    50                  55                  60                  


Leu Pro Asn Leu Leu Arg Gly Tyr Glu His Ile Arg Leu Ser Thr His 
65                  70                  75                  80  


Asn Val Ile Asn Ala Glu Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly 
                85                  90                  95      


Thr Ser Gly Ser Cys Pro Asn Val Thr Asn Gly Asn Gly Phe Phe Ala 
            100                 105                 110         


Thr Met Ala Trp Ala Val Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr 
        115                 120                 125             


Asn Ser Leu Thr Ile Glu Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp 
    130                 135                 140                 


Gln Ile Thr Val Trp Gly Phe His Ser Asp Xaa Glu Xaa Gln Met Ala 
145                 150                 155                 160 


Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn 
                165                 170                 175     


Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asn Gln 
            180                 185                 190         


Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp Tyr 
        195                 200                 205             


Met Val Gln Lys Ser Gly Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly 
    210                 215                 220                 


Ile Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys Val 
225                 230                 235                 240 


Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
                245                 250 


<210>  78
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal segment of Stalk of mouse adapted Influenza 
B/Malaysia/2506/2004 virus HA

<400>  78

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala 
        35                  40          


<210>  79
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal segment of Stalk of mouse adapted Influenza 
B/Malaysia/2506/2004 virus HA

<400>  79

Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
1               5                   10                  15      


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
            20                  25                  30          


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
        35                  40                  45              


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
    50                  55                  60                  


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
65                  70                  75                  80  


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
                85                  90                  95      


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
            100                 105                 110         


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
        115                 120                 125             


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
    130                 135                 140                 


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
145                 150                 155                 160 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
                165                 170                 175     


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
            180                 185                 190         


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
        195                 200                 205             


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
    210                 215                 220                 


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
225                 230                 235                 240 


Thr 
    


<210>  80
<211>  2312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus PB1

<400>  80
aatataaatc cttatttcct cttcatagat gtgcccatac aggcagcaat ttcaacaaca       60

ttcccataca ctggtgttcc cccttattcc catggaacgg gaacaggcta cacaatagac      120

accgtgatca gaacacatga gtactcaarc aaggggaaac agtacatttc tgatgttaca      180

ggatgcacaa tggtagatcc aacaaatggc ccattacccg aagataatga gccgagtgcc      240

tatgcgcaat tagattgcgt tttagaggct ttggatagaa tggatgaaga acacccaggt      300

ctgtttcaag cagcctcaca gaatgctatg gaggccctaa tggtcacaac tgtagacaaa      360

ttaacccagg ggagacagac ttttgattgg acagtatgca gaaaccaacc tgctgcaacg      420

gcactgaaca caacaataac ctcttttagg ttgaatgatt taaatggagc cgacaaaggt      480

ggattagtac ctttttgcca ggatatcatt gattcattag acagacctga aatgactttc      540

ttctcagtaa agaatataaa gaaaaaattg cctgccaaaa acagaaaggg tttcctcata      600

aagaggatac caatgaaggt aaaggacaaa ataaccaaag tggaatacat caaaagagca      660

ttatcattaa acacaatgac aaaagacgct gaaagaggca aactaaaaag aagagcgatt      720

gccaccgctg gaatacaaat cagagggttt gtattagtag ttgaaaactt ggctaaaaat      780

atatgtgaaa atctagaaca aagtggttta ccagtaggtg gaaacgagaa gaaagccaaa      840

ctgtcaaacg cagtggcaaa aatgctcagt aactgcccac ctggagggat cagcatgaca      900

gtaacaggag acaatactaa atggaatgaa tgtttaaacc caagaatctt tttggctatg      960

actgaaagaa taaccagaga cagcccaatt tggttcaggg atttttgtag tatagcaccg     1020

gtcctgttct ccaataagat agccagattg gggaaagggt ttatgataac aagcaaaaca     1080

aagagactga aggctcaaat accttgtcct gatctgttta gtatatcatt agaaagatat     1140

aatgaagaaa caagggcaaa attgaaaaag ctaaaaccat tcttcaatga agaaggaact     1200

gcatctttgt cacctgggat gatgatggga atgtttaata tgctatctac cgtgttgggg     1260

gtagctgcac taggtatcaa gaacattgga aacaaagaat acttatggga tggactgcaa     1320

tcttctgatg attttgctct atttgttaat gcaaaggatg aagaaacatg tatggaagga     1380

ataaacgact tttaccgaac atgtaaatta ttgggaataa acatgagcaa aaagaaaagt     1440

tactgtaatg agactggaat gtttgaattt acaagcatgt tctacagaga tggatttgta     1500

tctaattttg caatggaact cccttcattt ggggttgctg gagtaaatga atcagcagat     1560

atggcaatag ggatgacaat aataaagaac aacatgatca acaatggaat gggtccggca     1620

acagcacaaa cagccataca gttattcata gctgattata gatacaccta caaatgccac     1680

aggggagatt ccaaagtaga gggaaagaga atgaaaatca taaaggagtt atgggaaaac     1740

actaaaggaa gagatggtct attagtagca gatggtgggc ccaacattta caatttgaga     1800

aacttgcata ttccagaaat agtattaaag tataacttaa tggaccctga atacaaaggg     1860

cggttacttc atcctcaaaa tccctttgtg ggacatttgt ctattgaggg catcaaagag     1920

gcagatataa ccccagcaca tggtccagta aagaaaatgg actacgatgc ggtgtctgga     1980

actcatagtt ggagaaccaa aagaaacaga tctatactaa acactgatca gaggaacatg     2040

attcttgagg aacaatgcta cgctaagtgt tgcaacctat ttgaggcctg ttttaacagt     2100

gcatcataca ggaagccagt gggtcaacat agcatgcttg aggctatggc ccacagatta     2160

agaatggatg cacgattaga ttatgaatca ggaagaatgt caaaggatga ttttgagaaa     2220

gcaatggctc accttggtga gattgggtac atataagctt cgaagatgtc tatggggtta     2280

ttggtcatca ttgaatacat gcgatacaca aa                                   2312


<210>  81
<211>  2358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus PB2

<400>  81
ttcaagatga cattggccaa aattgaattg ttaaaacaac tgctaaggga caatgaagcc       60

aaaacagttt tgaagcaaac aacggtagac caatataaca taataagaaa attcaataca      120

tcaaggattg aaaagaatcc ttcactaagg atgaaatggg ccatgtgttc taattttccc      180

ttggctctaa ccaagggcga catggcaaat agaatcccct tggaatacaa aggaatacaa      240

cttaaaacaa atgctgaaga cataggaacc aaaggccaaa tgtgctcaat agcagcagtt      300

acttggtgga atacatatgg accaatagga gatactgaag gtttcgaaag ggtctacgaa      360

agcttttttc tcagaaaaat gagacttgac aatgccactt ggggccgaat aacttttggc      420

ccagttgaaa gagtgagaaa aagggtactg ctaaaccctc tcaccaagga aatgcctcca      480

gatgaggcga gcaatgtgat aatggaaata ttgttcccta aagaagcagg aataccaaga      540

gaatccactt ggatacatag rgaactgata aaagaaaaaa gagaaaaatt gaaaggaaca      600

atgataactc caatcgtact ggcatacatg cttgaaagag aactggttgc tcgaagaaga      660

ttcttgccag tggcaggagc aacatcagct gagttcatag aaatgctaca ctgcttacaa      720

ggtgaaaatt ggagacaaat atatcaccca ggagggaata aattaactga gtctaggtct      780

caatcaatga tagtagcttg tagaaaaata atcagaagat caatagtcgc ttcaaaccca      840

ctggagctag ctgtagaaat tgcaaacaag actgtgatag atactgaacc tttaaagtca      900

tgtctggcag ccatagacgg aggtgatgta gcttgtgaca taataagagc tgcattagga      960

ctaaagatca gacaaagaca aagatttgga cggcttgagt taaaaagaat atcaggaaga     1020

ggattcaaaa atgatgaaga aatattaata gggaacggaa caatacagaa gattggaata     1080

tgggacgggg aagaggagtt ccatgtaaga tgtggtgaat gcaggggaat attaaaaaag     1140

agtaaaatga aactggaaaa actactaata aattcagcca aaaaggagga catgagagat     1200

ttaataatct tatgcatggt attttctcaa gacactagga tgttccaagg ggtgagagga     1260

gaaataaatt ttcttaatcg agcaggccaa cttttatctc caatgtacca actccaacga     1320

tattttttga atagaagcaa cgaccttttt gatcaatggg ggtatgagga atcacccaaa     1380

gcaagtgaac tatatgggat aaatgaatca atgaatgcat ctgactatac attgaaaggg     1440

gttgtagtga caagaaatgt aattgacgac tttagctcta ctgaaacaga aaaagtatcc     1500

ataacaaaaa atcttagttt aataaaaagg actggggaag tcataatggg agctaatgac     1560

gtgagtgaat tagaatcaca agcacagctg atgataacat atgatacacc taagatgtgg     1620

gaaatgggaa caaccaaaga actggtgcaa aacacttatc aatgggtgct aaaaaacttg     1680

gtaacactga aggctcagtt tcttctagga aaagaggaca tgttccaatg ggatgcattt     1740

gaagcatttg agagcataat tcctcagaag atggctggtc agtacagtgg atttgcaaga     1800

gcagtgctca aacaaatgag agaccaggag gttatgaaaa ctgaccagtt cataaagttg     1860

ttgccttttt gtttctcacc accaaaatta aggagcaatg gggagcctta tcaattctta     1920

aaacttgtat tgaaaggagg aggggaaaat ttcatcgaag taaggaaagg gtcccctcta     1980

ttttcctata atccacaaac agaagtccta accatatgcg gcagaatgat gtcattaaaa     2040

gggaaaattg aagatgaaga aaggaataga tcaatgggga atgcagtatt agcaggcttt     2100

ctcgttagtg gcaagtatga cccagatctt ggagatttca aaactattga agaacttgaa     2160

aggctgaaac cgggggaaaa ggcaaatatc ttactttatc aaggaaagcc agttaaagta     2220

gttaaaagga aaaggtatag tgctttgtcc aatgacattt cacaaggaat taagagacaa     2280

agaatgacag ttgagtccat ggggtgggcc ttgagctaat ataaatttat ccattaattc     2340

aatgaacgca attgagtg                                                   2358


<210>  82
<211>  2248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus PA

<400>  82
atacttttat tacaagaaac ttccaaacta caataataca aaaggccaga aacacaatgg       60

cagaatttag tgaagatcct gaattacaac cagcaatgct attcaatatc tgcgtccatc      120

tagaggtttg ctatgtaata agtgacatga attttcttga cgaagaagga aaagcatata      180

cagcattaga aggacaaggg aaagaacaaa atttgagacc acaatatgaa gtaattgagg      240

gaatgccaag aaccatagca tggatggtcc aaagatcctt agctcaagag catggaatag      300

agactcccaa gtatctggct gatttgtttg attataaaac caagagattt atagaagttg      360

gaataacaaa aggattggct gatgattact tttggaaaaa gaaagaaaag ttgggaaata      420

gcatggaact gatgatattc agctacaatc aagactactc gttaagtaat gaatcctcat      480

tggatgagga agggaaaggg agagtgctaa gcagactcac agaacttcag gctgaattaa      540

gtctgaaaaa cctatggcaa gttctcatag gagaagaaga tgttgaaaag ggaattgact      600

ttaaacttgg acaaacaata tctagactaa gggatatatc tgttcccgct ggtttctcca      660

attttgaagg aatgaggagc tacatagaca atatagaccc aaaaggagca atagagagaa      720

atctagcaag gatgtctccc ttagtatcag tcacacctaa aaagttgaca tgggaggacc      780

taagaccaat agggcctcac atttacaacc atgagctacc agaagttcca tataatgcct      840

ttcttctaat gtctgatgaa ctggggctgg ccaatatgac tgagggaaag tccaaaaaac      900

cgaagacatt agccaaagaa tgtctagaaa agtactcaac actacgggat caaactracc      960

caatattaat aatgaaaagc gaaaaagcta atgaaaattt cctatggaag ctttggagag     1020

actgtgtaaa tacaataagt aatgaggaaa tgagtaacga gttacagaaa accaattatg     1080

ccaagtgggc cacaggggat ggattaacat accagaaaat aatgaaagaa gtagcaatag     1140

atgacgaaac aatgtgccaa gaagagccta aaatccctaa taaatgtaga gtggctgctt     1200

gggttcaaac agagatgaat ctattgagca ctctgacaag taaaagagct ctggacctac     1260

cagaaatagg gccagacgta gcacccgtgg agcatgtagg gagtgaaaga aggaaatact     1320

ttgttaatga aatcaactac tgtaaggcct ctacagttat gatgaagtat gtgctttttc     1380

acacttcatt gttgaatgaa agcaatgcca gcatgggaaa atacaaagta ataccaataa     1440

ccaatagagt agtaaatgaa acaggagaaa gtttcgacat gctttatggt ctggcggtta     1500

aaggacaatc tcatctgagg ggagatactg atgttgtaac agttgtaact ttcgaattta     1560

gtagtacaga cccaagagtg gactcaggaa agtggccaaa atatactgtg tttaggattg     1620

gctccctatt tgtgagtggg agggaaaaat ctgtgtacct gtattgccga gtgaatggca     1680

caaataagat ccaaatgaaa tggggaatgg aagctagaag atgtctgctt caatcaatgc     1740

aacaaatgga agcaattgtt gaacaggaat catcgataca gggatatgac atgaccaagg     1800

cttgtttcaa gggagacaga gtaaatagcc ccaaaacttt cagtattgga actcaagaag     1860

ggaaactagt aaaaggatcc tttggaaaag cactaagagt aatatttact aaatgtttga     1920

tgcactatgt atttggaaat gcccaattgg aggggtttag tgccgagtct aggagacttc     1980

tactgttgat ccaagcatta aaggacagaa agggcccttg ggtgttcgac ttagagggaa     2040

tgtattctgg aatagaagaa tgtattagca acaacccttg ggtaatacag agtgcatact     2100

ggtttaatga atggttgggc tttgaaaagg aggggagtaa agtgttagaa tcagtggatg     2160

aaataatgga tgaataaaag gacatggtac tcaatttggt actattttgt tcattatgta     2220

tctaaacatc caataaaaag aaccaaga                                        2248


<210>  83
<211>  1824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus HA


<220>
<221>  misc_feature
<222>  (641)..(641)
<223>  n is a, c, g, or t

<400>  83
atgaaggcaa taattgtact actcatggta gtaacatcca atgcagatcg aatctgcact       60

gggataacat cgtcaaactc accacatgtt gtcaaaactg ctactcaagg ggaggtcaat      120

gtgactggtg taataccact gacaacaaca cccaccaaat ctcattttgc aaatctcaaa      180

ggaacagaaa ccagagggaa actatgccca aaatgcctca actgcacaga tctggacgtg      240

gccttgggca gaccaaaatg cacggggaac ataccctcgg caagagtttc aatactccat      300

gaagtcagac ctgttacatc tgggtgcttt cctataatgc acgacagaac aaaaattaga      360

cagctgccta accttctcag aggatacgaa catatcaggt tatcaactca taacgttatc      420

aatgcagaaa atgcaccagg aggaccctac aaaattggaa cctcagggtc ttgccctaac      480

gttaccaatg gaaacggatt tttcgcaaca atggcttggg ccgtcccaaa aaacgacaac      540

aacaaaacag caacaaattc attaacaata gaagtaccat acatttgtac agaaggagaa      600

gaccaaatta ccgtttgggg gttccactct gatarcgaaa nccaaatggc aaagctctat      660

ggggactcaa agccccagaa gttcacctca tctgccaacg gagtgaccac acattacgtt      720

tcacagattg gtggcttccc aaatcaaaca gaagacggag gactaccaca aagtggtaga      780

attgttgttg attacatggt gcaaaaatct gggaaaacag gaacaattac ctatcaaaga      840

ggtattttat tgcctcaaaa agtgtggtgc gcaagtggca ggagcaaggt aataaaagga      900

tccttgcctt taattggaga agcagattgc ctccacgaaa aatacggtgg attaaacaaa      960

agcaagcctt actacacagg ggaacatgca aaggccatag gaaattgccc aatatgggtg     1020

aaaacaccct tgaagctggc caatggaacc aaatatagac ctcctgcaaa actattaaag     1080

gaaaggggtt tcttcggagc tattgctggt ttcttagaag gaggatggga aggaatgatt     1140

gcaggttggc acggatacac atcccatggg gcacatggag tagcggtggc agcagacctt     1200

aagagcactc aagaggccat aaacaagata acaaaaaatc tcaactcttt gagtgagctg     1260

gaagtaaaga atcttcaaag actaagcggt gccatggatg aactccacaa cgaaatacta     1320

gaactagacg agaaagtgga tgatctcaga gctgatacaa taagctcaca aatagaactc     1380

gcagtcctgc tttccaatga aggaataata aacagtgaag atgagcatct cttggcgctt     1440

gaaagaaagc tgaagaaaat gctgggcccc tctgctgtag agatagggaa tggatgcttt     1500

gaaaccaaac acaagtgcaa ccagacctgt ctcgacagaa tagctgctgg tacctttgat     1560

gcaggagaat tttctctccc cacttttgat tcactgaata ttactgctgc atctttaaat     1620

gacgatggat tggataatca tactatactg ctttactact caactgctgc ctccagtttg     1680

gctgtaacat tgatgatagc tatctttgtt gtttatatgg tctccagaga caatgtttct     1740

tgctccatct gtctataagg aaagttaaac cctgtatttt cctttattgt agtgcttgtt     1800

tgcttgttac cattacaaaa aacg                                            1824


<210>  84
<211>  1772
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus NP

<400>  84
caacaaaaga actgaaaatc aaaatgtcca acatggatat tgacggtatc aacactggga       60

caattgacaa agcaccggaa gaaataactt ctggaaccag tgggacaacc agaccaatca      120

tcagaccagc aacccttgcc ccaccaagca acaaacgaac ccggaaccca tccccggaaa      180

gagcaaccac aatcagtgaa gctgatgtcg gaaggaaaac ccaaaagaaa cagaccccga      240

cagagataaa gaagagcgtc tacaatatgg tagtgaaact gggtgaattc tataaccaga      300

tgatggtcaa agctggactt aacgatgaca tggagagaaa cctaattcaa aatgcgcatg      360

ctgtggaaag aattctattg gctgccactg atgacaagaa aactgaattc cagaagaaaa      420

agaatgccag agatgtcaaa gaagggaaag aagaaataga tcacaacaaa acagggggca      480

ccttttacaa gatggtaaga gatgataaaa ccatctactt cagccctata agagtcacct      540

ttttaaaaga agaagtaaaa acaatgtaca aaaccaccat ggggagtgat ggcttcagcg      600

gactaaatca cataatgatt gggcattcac agatgaatga tgtctgtttc caaagatcaa      660

aggcactaaa aagagttgga cttgaccctt cattaatcag tacctttgca ggaagcacac      720

tccccagaag atcaggtgca actggtgttg cgatcaaagg aggtggaact ctagtggctg      780

aagccattcg atttatagga agagcaatgg cagacagagg gctattgaga gacatcaaag      840

ccaagactgc gtatgaaaag attcttctga acctaaaaaa caaatgctct gcgccccaac      900

agaaggctct agttgatcaa gtgatcggaa gtagaaatcc agggattgca gacattgaag      960

acctaaccct acttgctcgt agtatggtcg ttgttaggcc ctctgtggcg agcaaagtag     1020

tgcttcccat aagcatttac gccaaaatac ctcaactagg gttcaacgtt gaagagtact     1080

ctatggttgg gtatgaagcc atggctcttt acaatatggc aacacctgtt tccatattaa     1140

gagtgggaga tgatgcaaag gacaaatcac aattattctt catgtcttgc ttcggagctg     1200

cctatgaaga cctgagagtt ttgtctgcat taacaggcac agaattcaag cctagatcag     1260

cattaaaatg caagggtttc catgttccag caaaggaaca ggtggaagga atgggggcag     1320

ctctgatgtc catcaagctc cagttttggg ctccaatgac cagatctggg ggaaacgaag     1380

taggtggaga cggggggtct ggccaaataa gttgcagccc agtgtttgca gtagaaagac     1440

ctattgctct aagcaagcaa gctgtaagaa gaatgctgtc aatgaatatt gagggacgtg     1500

atgcagatgt caaaggaaat ctactcaaga tgatgaatga ctcaatggct aagaaaacca     1560

atggaaatgc tttcattggg aagaaaatgt ttcaaatatc agacaaaaac aaaaccaatc     1620

ccgttgaaat tccaattaag caaaccatcc ccaatttctt ctttgggagg gacacagcag     1680

aggattatga tgacctcgat tattaaagca acaaaataga cactatgact gtgattgttt     1740

caatacgttt ggaatgtggg tgtttactct ta                                   1772


<210>  85
<211>  1483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus NA

<400>  85
aaatgaacaa tgctaccttc aactatacaa acgttaaccc tatttctcac atcaggggga       60

gtattattat cactatatgt gtcagcttca ttgtcatact tactatattc ggatatattg      120

ctaaaattcc catcaacaga aattactgca ccaacaatgc cattggattg tgcaaacgca      180

tcaaatgttc aggctgtgaa ccgttctgca acaaaagggg tgacacttct tctcccagaa      240

ccggagtgga catacccgcg tttatcttgc ccgggctcaa cctttcagaa agcactccta      300

attagccctc atagattcgg agaaaccaaa ggaaactcag ctcccttgat aataagggaa      360

ccttttattg cttgtggacc aaaggaatgc aaacactttg ctctaaccca ctatgcagcc      420

caaccagggg gatactacaa tggaacaaga ggagacagaa acaagctgag gcatctaatt      480

tcagtcaaat tgggcaaaat cccaacagta gaaaactcca ttttccacat ggcagcatgg      540

agcgggtccg catgccatga tggtaaggaa tggacatata tcggagttga tggccctgac      600

aataatgcat tgctcaaaat aaaatatgga gaagcatata ctgacacata ccattcctat      660

gcaaacaaca tcctaagaac acaagaaagt gcctgcaatt gcatcggggg aaattgttat      720

cttatgataa ctgatggctc agcttcaggt gttagtgaat gcagatttct taagattcga      780

gagggccgaa taataaaaga aatatttcca acaggaagaa taaaacatac tgaagaatgc      840

acatgcggat ttgctagcaa taaaaccata gaatgtgcct gtagagataa cagttacaca      900

gcaaaaagac cctttgtcaa attaaacgtg gagactgata cagcagaaat aagattgatg      960

tgcacagaga cttatttgga cacccccaga ccagatgatg gaagcataac agggccttgt     1020

gaatctaatg gggacaaagg gagtggaggc atcaagggag gatttgtcca tcaaagaatg     1080

gcatccaaga ttggaaggtg gtactctcga acgatgtcta aaactaaaag gatggggatg     1140

gggctgtatg tcaartatga tggagaccca tgggctgaca gtgatgccct tgcttttagt     1200

ggagtaatgg tttcaatgga agaacctggt tggtactcct ttggcttcga aataaaagac     1260

aagaaatgtg atgtcccctg tattgggata gagatggtac atgatggtgg aaaagagact     1320

tggcactcag cagctacagc catttactgt ttaatgggct caggacagct gctgtgggac     1380

actgtcacag gtgttaatat ggctctgtaa tggaggaatg gttgagtctg ttctaaaccc     1440

tttgttccta ttttgtttga acaattgtcc ttactgaact taa                       1483


<210>  86
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus M

<400>  86
cgctgtttgg agacacaatt gcctacctgc tttcattgac agaagatgga gaaggcaaag       60

cagaactagc agaaaaatta cactgttggt ttggtgggaa agaatttgac ctagactctg      120

ccttggaatg gataaaaaac aaaagatgct taactgatat acaaaaagca ctaattggtg      180

cctctatatg ctttttaaaa cccaaagacc aggaaagaaa aagaagattc atcacagaac      240

ccttatcagg aatgggaaca acagcaacaa aaaagaaagg cctgattctg gctgagagaa      300

aaatgagaag atgtgtgagc tttcatgaag catttgaaat agcagaaggc catgaaagct      360

cagcgctact atactgtctc atggtcatgt acctgaatcc tggaaattat tcaatgcaag      420

taaaactagg aacgctctgt gctttatgcg agaaacaagc atcacattca cacagggctc      480

atagcagagc agcgagatct tcagtgcctg gagtgagacg agaaatgcag atggtctcag      540

ctatgaacac agcgaaaaca atgaatggaa tgggaaaagg agaagacgtc caaaagctgg      600

cagaagagct gcaaagcaac attggagtgc tgagatctct tggggcaagt caaaagaatg      660

gggaaggaat tgcaaargat gtaatggaag tgctaaagca gagctctatg ggaaattcag      720

ctcttgtgaa gaaatatcta taatgctcga accatttcag attctttcaa tttgttcttt      780

tatcttatca gctctccatt tcatggcttg gacaataggg catttgaatc aaataaaaag      840

aggaataaac atgaaaatac gaataaaagg tccaaacaaa gagacaataa acagagaggt      900

atcaattttg agacacagtt accaaaaaga aatccaggcc aaagaaacaa tgaaggaagt      960

actctctgac aacatggagg tattgagtga ccacataata attgaggggc tttctgccga     1020

agagataata aaaatgggtg aaacagtttt ggagatagaa gaattgcatt aaattcaatt     1080

tttactgtat ttcttactat gcatttaagc aaattgtaat caatgtcagc aaataaactg     1140


<210>  87
<211>  1033
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of mouse adapted Influenza 
B/Malaysia/2506/2004 virus NS

<400>  87
cgaacaacat gaccacaaca caaattgagg tgggtccggg agcaaccaat gccaccataa       60

actttgaagc aggaattctg gagtgctatg aaaggctttc atggcaaaga gcccttgact      120

accctggtca agaccgccta aacagactaa agagaaaatt agagtcaaga ataaagactc      180

acaacaaaag tgagcctgaa agtaaaagga tgtcccttga agagagaaaa gcaattggag      240

taaaaatgat gaaagtactc ctatttatgg atccgtctgc tggaattgaa gggtttgagc      300

catactgtat gaaaagttcc tcaaatagca actgtacgaa atacaattgg accgattacc      360

cttcaacacc agggaggtgc cttgatgaca tagaagaaga accagaggat gttgatggcc      420

caactgaaat agtattaagg gacatgaaca acaaagatgc aaggcaaaag ataaaggagg      480

aagtaaacac tcagaaagaa gggaagttcc gtttgacaat aaaaagggat atgcgtaatg      540

tattgtcctt gagagtgttg gtaaacggaa cattcctcaa acatcccaat ggatacaagt      600

ccttatcaac tctgcataga ttgaatgcat atgaccagag tggaaggctt gttgctaaac      660

ttgttgctac tgatgatctt acagtggagg atgaagaaga tggccatcgg atcctcaact      720

cactcttcga gcgtcttaat gaaggacatt caaagccaat tcgagcagct gaaactgcgg      780

tgggagtctt atcccaattt ggtcaagagc accgattatc accagaagag ggagacaatt      840

agactggtca cggaagaact ttatctttta agtaaaagaa ttgatgataa catattgttc      900

cacaaaacag taatagctaa cagctccata atagctgaca tggttgtatc attatcatta      960

ttagaaacat tgtatgaaat gaaggatgta gttgaagtgt acagcaggca gtgcttgtga     1020

atttaaaata aaa                                                        1033


<210>  88
<211>  585
<212>  PRT
<213>  influenza B/Malaysia/2506/20/03

<220>
<223>  full length amino acid sequence for influenza 
B/Malaysia/2506/20/03 HA 

<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa = Ile or Thr

<400>  88

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg Val 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu Asn 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu Val 
            180                 185                 190         


Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe 
        195                 200                 205             


His Ser Asp Asn Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser Lys 
    210                 215                 220                 


Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val 
225                 230                 235                 240 


Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu Pro 
                245                 250                 255     


Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly Lys 
            260                 265                 270         


Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys Val 
        275                 280                 285             


Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu 
    290                 295                 300                 


Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys 
305                 310                 315                 320 


Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys 
                325                 330                 335     


Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr 
            340                 345                 350         


Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
        355                 360                 365             


Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His 
    370                 375                 380                 


Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu 
385                 390                 395                 400 


Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser 
                405                 410                 415     


Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met 
            420                 425                 430         


Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp 
        435                 440                 445             


Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu 
    450                 455                 460                 


Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu 
465                 470                 475                 480 


Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly 
                485                 490                 495     


Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp 
            500                 505                 510         


Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr 
        515                 520                 525             


Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu 
    530                 535                 540                 


Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Ala Val Thr Leu Met Ile Ala Ile Phe Val Val Tyr Met Val Ser Arg 
                565                 570                 575     


Asp Asn Val Ser Cys Ser Ile Cys Leu 
            580                 585 


<210>  89
<211>  15
<212>  PRT
<213>  influenza B/Malaysia/2506/20/03

<220>
<223>  Signal Peptide

<400>  89

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala 
1               5                   10                  15  


<210>  90
<211>  347
<212>  PRT
<213>  influenza B/Malaysia/2506/20/03

<220>
<223>  HA1 Domain

<220>
<221>  misc_feature
<222>  (199)..(199)
<223>  Xaa = Ile or Thr

<400>  90

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg 
65                  70                  75                  80  


Val Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu 
                165                 170                 175     


Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly 
            180                 185                 190         


Phe His Ser Asp Asn Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser 
        195                 200                 205             


Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr 
    210                 215                 220                 


Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu 
225                 230                 235                 240 


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly 
                245                 250                 255     


Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys 
            260                 265                 270         


Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro 
        275                 280                 285             


Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
    290                 295                 300                 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
305                 310                 315                 320 


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
                325                 330                 335     


Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg 
            340                 345         


<210>  91
<211>  223
<212>  PRT
<213>  influenza B/Malaysia/2506/20/03

<220>
<223>  HA2 Domain

<400>  91

Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly Val 
            20                  25                  30          


Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile 
        35                  40                  45              


Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln 
    50                  55                  60                  


Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu 
65                  70                  75                  80  


Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile 
                85                  90                  95      


Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp 
            100                 105                 110         


Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro 
        115                 120                 125             


Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys 
    130                 135                 140                 


Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly 
145                 150                 155                 160 


Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser 
                165                 170                 175     


Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr Ser 
            180                 185                 190         


Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala Ile Phe Val 
        195                 200                 205             


Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
    210                 215                 220             


<210>  92
<211>  42
<212>  PRT
<213>  influenza B/Malaysia/2506/20/03

<220>
<223>  N-Terminal Segment of Stalk (encompasses alanine at 
interface with globular head domain) 

<400>  92

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala 
        35                  40          


<210>  93
<211>  241
<212>  PRT
<213>  influenza B/Malaysia/2506/20/03

<220>
<223>  C-Terminal Segment of Stalk (encompasses alanine at 
interface with globular head domain)

<400>  93

Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro 
1               5                   10                  15      


Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp 
            20                  25                  30          


Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro 
        35                  40                  45              


Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe 
    50                  55                  60                  


Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr 
65                  70                  75                  80  


Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr 
                85                  90                  95      


Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu 
            100                 105                 110         


Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu 
        115                 120                 125             


His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala 
    130                 135                 140                 


Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu 
145                 150                 155                 160 


Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys 
                165                 170                 175     


Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys 
            180                 185                 190         


Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala 
        195                 200                 205             


Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser 
    210                 215                 220                 


Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His 
225                 230                 235                 240 


Thr 
    


<210>  94
<211>  250
<212>  PRT
<213>  influenza B/Malaysia/2506/20/03

<220>
<223>  Globular Head Domain

<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  Xaa = Ile or Thr

<400>  94

Asn Leu Lys Gly Thr Glu Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu 
1               5                   10                  15      


Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys Thr Gly 
            20                  25                  30          


Asn Ile Pro Ser Ala Arg Val Ser Ile Leu His Glu Val Arg Pro Val 
        35                  40                  45              


Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile Arg Gln 
    50                  55                  60                  


Leu Pro Asn Leu Leu Arg Gly Tyr Glu His Ile Arg Leu Ser Thr His 
65                  70                  75                  80  


Asn Val Ile Asn Ala Glu Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly 
                85                  90                  95      


Thr Ser Gly Ser Cys Pro Asn Val Thr Asn Gly Asn Gly Phe Phe Ala 
            100                 105                 110         


Thr Met Ala Trp Ala Val Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr 
        115                 120                 125             


Asn Ser Leu Thr Ile Glu Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp 
    130                 135                 140                 


Gln Ile Thr Val Trp Gly Phe His Ser Asp Asn Glu Xaa Gln Met Ala 
145                 150                 155                 160 


Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn 
                165                 170                 175     


Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asn Gln 
            180                 185                 190         


Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp Tyr 
        195                 200                 205             


Met Val Gln Lys Ser Gly Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly 
    210                 215                 220                 


Ile Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys Val 
225                 230                 235                 240 


Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu 
                245                 250


<210>  95
<211>  533
<212>  PRT
<213>  influenza B/Malaysia/2506/20/03

<220>
<223>  Ectodomain

<220>
<221>  misc_feature
<222>  (199)..(199)
<223>  Xaa = Ile or Thr

<400>  95

Asp Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val 
1               5                   10                  15      


Lys Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu 
            20                  25                  30          


Thr Thr Thr Pro Thr Lys Ser His Phe Ala Asn Leu Lys Gly Thr Glu 
        35                  40                  45              


Thr Arg Gly Lys Leu Cys Pro Lys Cys Leu Asn Cys Thr Asp Leu Asp 
    50                  55                  60                  


Val Ala Leu Gly Arg Pro Lys Cys Thr Gly Asn Ile Pro Ser Ala Arg 
65                  70                  75                  80  


Val Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro 
                85                  90                  95      


Ile Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg 
            100                 105                 110         


Gly Tyr Glu His Ile Arg Leu Ser Thr His Asn Val Ile Asn Ala Glu 
        115                 120                 125             


Asn Ala Pro Gly Gly Pro Tyr Lys Ile Gly Thr Ser Gly Ser Cys Pro 
    130                 135                 140                 


Asn Val Thr Asn Gly Asn Gly Phe Phe Ala Thr Met Ala Trp Ala Val 
145                 150                 155                 160 


Pro Lys Asn Asp Asn Asn Lys Thr Ala Thr Asn Ser Leu Thr Ile Glu 
                165                 170                 175     


Val Pro Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly 
            180                 185                 190         


Phe His Ser Asp Asn Glu Xaa Gln Met Ala Lys Leu Tyr Gly Asp Ser 
        195                 200                 205             


Lys Pro Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr 
    210                 215                 220                 


Val Ser Gln Ile Gly Gly Phe Pro Asn Gln Thr Glu Asp Gly Gly Leu 
225                 230                 235                 240 


Pro Gln Ser Gly Arg Ile Val Val Asp Tyr Met Val Gln Lys Ser Gly 
                245                 250                 255     


Lys Thr Gly Thr Ile Thr Tyr Gln Arg Gly Ile Leu Leu Pro Gln Lys 
            260                 265                 270         


Val Trp Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro 
        275                 280                 285             


Leu Ile Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn 
    290                 295                 300                 


Lys Ser Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
305                 310                 315                 320 


Cys Pro Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys 
                325                 330                 335     


Tyr Arg Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala 
            340                 345                 350         


Ile Ala Gly Phe Leu Glu Gly Gly Trp Glu Gly Met Ile Ala Gly Trp 
        355                 360                 365             


His Gly Tyr Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp 
    370                 375                 380                 


Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn 
385                 390                 395                 400 


Ser Leu Ser Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala 
                405                 410                 415     


Met Asp Glu Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp 
            420                 425                 430         


Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu 
        435                 440                 445             


Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala 
    450                 455                 460                 


Leu Glu Arg Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Glu Ile 
465                 470                 475                 480 


Gly Asn Gly Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu 
                485                 490                 495     


Asp Arg Ile Ala Ala Gly Thr Phe Asp Ala Gly Glu Phe Ser Leu Pro 
            500                 505                 510         


Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly 
        515                 520                 525             


Leu Asp Asn His Thr 
    530             