                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  Consequences Of A Defective Switch In Cutaneous Squamous Cell 
       Carcinoma (SCC)

<130>  9869SG4510

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human microRNA-198 (miRNA-198) DNA sequence

<400>  1
ggtccagagg ggagataggt tc                                                22


<210>  2
<211>  8
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5' section of human microRNA-198 (miRNA-198)

<400>  2
gtccagag                                                                 8


<210>  3
<211>  308
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Follistatin-related protein 1 (FSTL1)

<400>  3

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala Glu Glu Glu Leu Arg Ser Lys Ser Lys Ile Cys Ala 
            20                  25                  30          


Asn Val Phe Cys Gly Ala Gly Arg Glu Cys Ala Val Thr Glu Lys Gly 
        35                  40                  45              


Glu Pro Thr Cys Leu Cys Ile Glu Gln Cys Lys Pro His Lys Arg Pro 
    50                  55                  60                  


Val Cys Gly Ser Asn Gly Lys Thr Tyr Leu Asn His Cys Glu Leu His 
65                  70                  75                  80  


Arg Asp Ala Cys Leu Thr Gly Ser Lys Ile Gln Val Asp Tyr Asp Gly 
                85                  90                  95      


His Cys Lys Glu Lys Lys Ser Val Ser Pro Ser Ala Ser Pro Val Val 
            100                 105                 110         


Cys Tyr Gln Ser Asn Arg Asp Glu Leu Arg Arg Arg Ile Ile Gln Trp 
        115                 120                 125             


Leu Glu Ala Glu Ile Ile Pro Asp Gly Trp Phe Ser Lys Gly Ser Asn 
    130                 135                 140                 


Tyr Ser Glu Ile Leu Asp Lys Tyr Phe Lys Asn Phe Asp Asn Gly Asp 
145                 150                 155                 160 


Ser Arg Leu Asp Ser Ser Glu Phe Leu Lys Phe Val Glu Gln Asn Glu 
                165                 170                 175     


Thr Ala Ile Asn Ile Thr Thr Tyr Pro Asp Gln Glu Asn Asn Lys Leu 
            180                 185                 190         


Leu Arg Gly Leu Cys Val Asp Ala Leu Ile Glu Leu Ser Asp Glu Asn 
        195                 200                 205             


Ala Asp Trp Lys Leu Ser Phe Gln Glu Phe Leu Lys Cys Leu Asn Pro 
    210                 215                 220                 


Ser Phe Asn Pro Pro Glu Lys Lys Cys Ala Leu Glu Asp Glu Thr Tyr 
225                 230                 235                 240 


Ala Asp Gly Ala Glu Thr Glu Val Asp Cys Asn Arg Cys Val Cys Ala 
                245                 250                 255     


Cys Gly Asn Trp Val Cys Thr Ala Met Thr Cys Asp Gly Lys Asn Gln 
            260                 265                 270         


Lys Gly Ala Gln Thr Gln Thr Glu Glu Glu Met Thr Arg Tyr Val Gln 
        275                 280                 285             


Glu Leu Gln Lys His Gln Glu Thr Ala Glu Lys Thr Lys Arg Val Ser 
    290                 295                 300                 


Thr Lys Glu Ile 
305             


<210>  4
<211>  1272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Protein diaphanous homolog 1 (DIAPH1)

<400>  4

Met Glu Pro Pro Gly Gly Ser Leu Gly Pro Gly Arg Gly Thr Arg Asp 
1               5                   10                  15      


Lys Lys Lys Gly Arg Ser Pro Asp Glu Leu Pro Ser Ala Gly Gly Asp 
            20                  25                  30          


Gly Gly Lys Ser Lys Lys Phe Thr Leu Lys Arg Leu Met Ala Asp Glu 
        35                  40                  45              


Leu Glu Arg Phe Thr Ser Met Arg Ile Lys Lys Glu Lys Glu Lys Pro 
    50                  55                  60                  


Asn Ser Ala His Arg Asn Ser Ser Ala Ser Tyr Gly Asp Asp Pro Thr 
65                  70                  75                  80  


Ala Gln Ser Leu Gln Asp Val Ser Asp Glu Gln Val Leu Val Leu Phe 
                85                  90                  95      


Glu Gln Met Leu Leu Asp Met Asn Leu Asn Glu Glu Lys Gln Gln Pro 
            100                 105                 110         


Leu Arg Glu Lys Asp Ile Ile Ile Lys Arg Glu Met Val Ser Gln Tyr 
        115                 120                 125             


Leu Tyr Thr Ser Lys Ala Gly Met Ser Gln Lys Glu Ser Ser Lys Ser 
    130                 135                 140                 


Ala Met Met Tyr Ile Gln Glu Leu Arg Ser Gly Leu Arg Asp Met Pro 
145                 150                 155                 160 


Leu Leu Ser Cys Leu Glu Ser Leu Arg Val Ser Leu Asn Asn Asn Pro 
                165                 170                 175     


Val Ser Trp Val Gln Thr Phe Gly Ala Glu Gly Leu Ala Ser Leu Leu 
            180                 185                 190         


Asp Ile Leu Lys Arg Leu His Asp Glu Lys Glu Glu Thr Ala Gly Ser 
        195                 200                 205             


Tyr Asp Ser Arg Asn Lys His Glu Ile Ile Arg Cys Leu Lys Ala Phe 
    210                 215                 220                 


Met Asn Asn Lys Phe Gly Ile Lys Thr Met Leu Glu Thr Glu Glu Gly 
225                 230                 235                 240 


Ile Leu Leu Leu Val Arg Ala Met Asp Pro Ala Val Pro Asn Met Met 
                245                 250                 255     


Ile Asp Ala Ala Lys Leu Leu Ser Ala Leu Cys Ile Leu Pro Gln Pro 
            260                 265                 270         


Glu Asp Met Asn Glu Arg Val Leu Glu Ala Met Thr Glu Arg Ala Glu 
        275                 280                 285             


Met Asp Glu Val Glu Arg Phe Gln Pro Leu Leu Asp Gly Leu Lys Ser 
    290                 295                 300                 


Gly Thr Thr Ile Ala Leu Lys Val Gly Cys Leu Gln Leu Ile Asn Ala 
305                 310                 315                 320 


Leu Ile Thr Pro Ala Glu Glu Leu Asp Phe Arg Val His Ile Arg Ser 
                325                 330                 335     


Glu Leu Met Arg Leu Gly Leu His Gln Val Leu Gln Asp Leu Arg Glu 
            340                 345                 350         


Ile Glu Asn Glu Asp Met Arg Val Gln Leu Asn Val Phe Asp Glu Gln 
        355                 360                 365             


Gly Glu Glu Asp Ser Tyr Asp Leu Lys Gly Arg Leu Asp Asp Ile Arg 
    370                 375                 380                 


Met Glu Met Asp Asp Phe Asn Glu Val Phe Gln Ile Leu Leu Asn Thr 
385                 390                 395                 400 


Val Lys Asp Ser Lys Ala Glu Pro His Phe Leu Ser Ile Leu Gln His 
                405                 410                 415     


Leu Leu Leu Val Arg Asn Asp Tyr Glu Ala Arg Pro Gln Tyr Tyr Lys 
            420                 425                 430         


Leu Ile Glu Glu Cys Ile Ser Gln Ile Val Leu His Lys Asn Gly Ala 
        435                 440                 445             


Asp Pro Asp Phe Lys Cys Arg His Leu Gln Ile Glu Ile Glu Gly Leu 
    450                 455                 460                 


Ile Asp Gln Met Ile Asp Lys Thr Lys Val Glu Lys Ser Glu Ala Lys 
465                 470                 475                 480 


Ala Ala Glu Leu Glu Lys Lys Leu Asp Ser Glu Leu Thr Ala Arg His 
                485                 490                 495     


Glu Leu Gln Val Glu Met Lys Lys Met Glu Ser Asp Phe Glu Gln Lys 
            500                 505                 510         


Leu Gln Asp Leu Gln Gly Glu Lys Asp Ala Leu His Ser Glu Lys Gln 
        515                 520                 525             


Gln Ile Ala Thr Glu Lys Gln Asp Leu Glu Ala Glu Val Ser Gln Leu 
    530                 535                 540                 


Thr Gly Glu Val Ala Lys Leu Thr Lys Glu Leu Glu Asp Ala Lys Lys 
545                 550                 555                 560 


Glu Met Ala Ser Leu Ser Ala Ala Ala Ile Thr Val Pro Pro Ser Val 
                565                 570                 575     


Pro Ser Arg Ala Pro Val Pro Pro Ala Pro Pro Leu Pro Gly Asp Ser 
            580                 585                 590         


Gly Thr Ile Ile Pro Pro Pro Pro Ala Pro Gly Asp Ser Thr Thr Pro 
        595                 600                 605             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Gly 
    610                 615                 620                 


Val Cys Ile Ser Ser Pro Pro Ser Leu Pro Gly Gly Thr Ala Ile Ser 
625                 630                 635                 640 


Pro Pro Pro Pro Leu Ser Gly Asp Ala Thr Ile Pro Pro Pro Pro Pro 
                645                 650                 655     


Leu Pro Glu Gly Val Gly Ile Pro Ser Pro Ser Ser Leu Pro Gly Gly 
            660                 665                 670         


Thr Ala Ile Pro Pro Pro Pro Pro Leu Pro Gly Ser Ala Arg Ile Pro 
        675                 680                 685             


Pro Pro Pro Pro Pro Leu Pro Gly Ser Ala Gly Ile Pro Pro Pro Pro 
    690                 695                 700                 


Pro Pro Leu Pro Gly Glu Ala Gly Met Pro Pro Pro Pro Pro Pro Leu 
705                 710                 715                 720 


Pro Gly Gly Pro Gly Ile Pro Pro Pro Pro Pro Phe Pro Gly Gly Pro 
                725                 730                 735     


Gly Ile Pro Pro Pro Pro Pro Gly Met Gly Met Pro Pro Pro Pro Pro 
            740                 745                 750         


Phe Gly Phe Gly Val Pro Ala Ala Pro Val Leu Pro Phe Gly Leu Thr 
        755                 760                 765             


Pro Lys Lys Leu Tyr Lys Pro Glu Val Gln Leu Arg Arg Pro Asn Trp 
    770                 775                 780                 


Ser Lys Leu Val Ala Glu Asp Leu Ser Gln Asp Cys Phe Trp Thr Lys 
785                 790                 795                 800 


Val Lys Glu Asp Arg Phe Glu Asn Asn Glu Leu Phe Ala Lys Leu Thr 
                805                 810                 815     


Leu Thr Phe Ser Ala Gln Thr Lys Thr Ser Lys Ala Lys Lys Asp Gln 
            820                 825                 830         


Glu Gly Gly Glu Glu Lys Lys Ser Val Gln Lys Lys Lys Val Lys Glu 
        835                 840                 845             


Leu Lys Val Leu Asp Ser Lys Thr Ala Gln Asn Leu Ser Ile Phe Leu 
    850                 855                 860                 


Gly Ser Phe Arg Met Pro Tyr Gln Glu Ile Lys Asn Val Ile Leu Glu 
865                 870                 875                 880 


Val Asn Glu Ala Val Leu Thr Glu Ser Met Ile Gln Asn Leu Ile Lys 
                885                 890                 895     


Gln Met Pro Glu Pro Glu Gln Leu Lys Met Leu Ser Glu Leu Lys Asp 
            900                 905                 910         


Glu Tyr Asp Asp Leu Ala Glu Ser Glu Gln Phe Gly Val Val Met Gly 
        915                 920                 925             


Thr Val Pro Arg Leu Arg Pro Arg Leu Asn Ala Ile Leu Phe Lys Leu 
    930                 935                 940                 


Gln Phe Ser Glu Gln Val Glu Asn Ile Lys Pro Glu Ile Val Ser Val 
945                 950                 955                 960 


Thr Ala Ala Cys Glu Glu Leu Arg Lys Ser Glu Ser Phe Ser Asn Leu 
                965                 970                 975     


Leu Glu Ile Thr Leu Leu Val Gly Asn Tyr Met Asn Ala Gly Ser Arg 
            980                 985                 990         


Asn Ala Gly Ala Phe Gly Phe Asn  Ile Ser Phe Leu Cys  Lys Leu Arg 
        995                 1000                 1005             


Asp Thr  Lys Ser Thr Asp Gln  Lys Met Thr Leu Leu  His Phe Leu 
    1010                 1015                 1020             


Ala Glu  Leu Cys Glu Asn Asp  Tyr Pro Asp Val Leu  Lys Phe Pro 
    1025                 1030                 1035             


Asp Glu  Leu Ala His Val Glu  Lys Ala Ser Arg Val  Ser Ala Glu 
    1040                 1045                 1050             


Asn Leu  Gln Lys Asn Leu Asp  Gln Met Lys Lys Gln  Ile Ser Asp 
    1055                 1060                 1065             


Val Glu  Arg Asp Val Gln Asn  Phe Pro Ala Ala Thr  Asp Glu Lys 
    1070                 1075                 1080             


Asp Lys  Phe Val Glu Lys Met  Thr Ser Phe Val Lys  Asp Ala Gln 
    1085                 1090                 1095             


Glu Gln  Tyr Asn Lys Leu Arg  Met Met His Ser Asn  Met Glu Thr 
    1100                 1105                 1110             


Leu Tyr  Lys Glu Leu Gly Glu  Tyr Phe Leu Phe Asp  Pro Lys Lys 
    1115                 1120                 1125             


Leu Ser  Val Glu Glu Phe Phe  Met Asp Leu His Asn  Phe Arg Asn 
    1130                 1135                 1140             


Met Phe  Leu Gln Ala Val Lys  Glu Asn Gln Lys Arg  Arg Glu Thr 
    1145                 1150                 1155             


Glu Glu  Lys Met Arg Arg Ala  Lys Leu Ala Lys Glu  Lys Ala Glu 
    1160                 1165                 1170             


Lys Glu  Arg Leu Glu Lys Gln  Gln Lys Arg Glu Gln  Leu Ile Asp 
    1175                 1180                 1185             


Met Asn  Ala Glu Gly Asp Glu  Thr Gly Val Met Asp  Ser Leu Leu 
    1190                 1195                 1200             


Glu Ala  Leu Gln Ser Gly Ala  Ala Phe Arg Arg Lys  Arg Gly Pro 
    1205                 1210                 1215             


Arg Gln  Ala Asn Arg Lys Ala  Gly Cys Ala Val Thr  Ser Leu Leu 
    1220                 1225                 1230             


Ala Ser  Glu Leu Thr Lys Asp  Asp Ala Met Ala Ala  Val Pro Ala 
    1235                 1240                 1245             


Lys Val  Ser Lys Asn Ser Glu  Thr Phe Pro Thr Ile  Leu Glu Glu 
    1250                 1255                 1260             


Ala Lys  Glu Leu Val Gly Arg  Ala Ser 
    1265                 1270         


<210>  5
<211>  1193
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Laminin subunit gamma-2 (LAMC2)

<400>  5

Met Pro Ala Leu Trp Leu Gly Cys Cys Leu Cys Phe Ser Leu Leu Leu 
1               5                   10                  15      


Pro Ala Ala Arg Ala Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly 
            20                  25                  30          


Lys Ser Arg Gln Cys Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly 
        35                  40                  45              


Asn Gly Phe Arg Cys Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His 
    50                  55                  60                  


Cys Glu Lys Cys Lys Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg 
65                  70                  75                  80  


Cys Leu Pro Cys Asn Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys 
                85                  90                  95      


Asp Asn Ser Gly Arg Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg 
            100                 105                 110         


Cys Asp Arg Cys Leu Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys 
        115                 120                 125             


Thr Gln Asp Gln Arg Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala 
    130                 135                 140                 


Gly Ile Ala Gly Pro Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala 
145                 150                 155                 160 


Val Thr Gly Glu Arg Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu 
                165                 170                 175     


Asp Gly Gly Asn Pro Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His 
            180                 185                 190         


Ser Ala Ser Cys Arg Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr 
        195                 200                 205             


Ser Thr Phe His Gln Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn 
    210                 215                 220                 


Gly Ser Pro Ala Lys Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe 
225                 230                 235                 240 


Ser Ser Ala Gln Arg Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys 
                245                 250                 255     


Phe Leu Gly Asn Gln Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp 
            260                 265                 270         


Tyr Arg Val Asp Arg Gly Gly Arg His Pro Ser Ala His Asp Val Ile 
        275                 280                 285             


Leu Glu Gly Ala Gly Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly 
    290                 295                 300                 


Lys Thr Leu Pro Cys Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn 
305                 310                 315                 320 


Glu His Pro Ser Asn Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr 
                325                 330                 335     


Arg Arg Leu Leu Arg Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr 
            340                 345                 350         


Gly Glu Tyr Ser Thr Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala 
        355                 360                 365             


Arg Pro Val Ser Gly Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys 
    370                 375                 380                 


Pro Val Gly Tyr Lys Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr 
385                 390                 395                 400 


Lys Arg Asp Ser Ala Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys 
                405                 410                 415     


Asn Cys Gln Gly Gly Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr 
            420                 425                 430         


Ser Gly Asp Glu Asn Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly 
        435                 440                 445             


Phe Tyr Asn Asp Pro His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys 
    450                 455                 460                 


His Asn Gly Phe Ser Cys Ser Val Met Pro Glu Thr Glu Glu Val Val 
465                 470                 475                 480 


Cys Asn Asn Cys Pro Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys 
                485                 490                 495     


Ala Asp Gly Tyr Phe Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg 
            500                 505                 510         


Pro Cys Gln Pro Cys Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser 
        515                 520                 525             


Gly Asn Cys Asp Arg Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn 
    530                 535                 540                 


Thr Ala Gly Ile Tyr Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp 
545                 550                 555                 560 


Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn 
                565                 570                 575     


Pro Met Gly Ser Glu Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val 
            580                 585                 590         


Cys Lys Pro Gly Phe Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser 
        595                 600                 605             


Cys Pro Ala Cys Tyr Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met 
    610                 615                 620                 


Gln Gln Leu Gln Arg Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly 
625                 630                 635                 640 


Asp Gly Val Val Pro Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala 
                645                 650                 655     


Glu Gln Ala Leu Gln Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly 
            660                 665                 670         


Ala Ser Arg Ser Leu Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu 
        675                 680                 685             


Asn Ser Tyr Gln Ser Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg 
    690                 695                 700                 


Val Arg Ala Leu Gly Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His 
705                 710                 715                 720 


Arg Leu Ile Thr Gln Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser 
                725                 730                 735     


Leu Gly Asn Thr Asn Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn 
            740                 745                 750         


Gly Phe Lys Ser Leu Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His 
        755                 760                 765             


Val Glu Ser Ala Ser Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp 
    770                 775                 780                 


Tyr Ser Lys Gln Ala Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly 
785                 790                 795                 800 


Val Gly Ser Gly Ser Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu 
                805                 810                 815     


Val Glu Lys Leu Glu Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg 
            820                 825                 830         


Glu Ala Thr Gln Ala Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser 
        835                 840                 845             


Leu Arg Leu Leu Asp Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln 
    850                 855                 860                 


Ser Phe Gln Val Glu Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser 
865                 870                 875                 880 


Leu Ser Ser Leu Val Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln 
                885                 890                 895     


Lys Asn Leu Gly Asn Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn 
            900                 905                 910         


Gly Lys Ser Gly Arg Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn 
        915                 920                 925             


Leu Ala Lys Ser Arg Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr 
    930                 935                 940                 


Phe Tyr Glu Val Glu Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu 
945                 950                 955                 960 


Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu 
                965                 970                 975     


Ser Tyr Ile Ser Gln Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln 
            980                 985                 990         


Ala Glu Arg Ala Leu Gly Ser Ala  Ala Ala Asp Ala Gln  Arg Ala Lys 
        995                 1000                 1005             


Asn Gly  Ala Gly Glu Ala Leu  Glu Ile Ser Ser Glu  Ile Glu Gln 
    1010                 1015                 1020             


Glu Ile  Gly Ser Leu Asn Leu  Glu Ala Asn Val Thr  Ala Asp Gly 
    1025                 1030                 1035             


Ala Leu  Ala Met Glu Lys Gly  Leu Ala Ser Leu Lys  Ser Glu Met 
    1040                 1045                 1050             


Arg Glu  Val Glu Gly Glu Leu  Glu Arg Lys Glu Leu  Glu Phe Asp 
    1055                 1060                 1065             


Thr Asn  Met Asp Ala Val Gln  Met Val Ile Thr Glu  Ala Gln Lys 
    1070                 1075                 1080             


Val Asp  Thr Arg Ala Lys Asn  Ala Gly Val Thr Ile  Gln Asp Thr 
    1085                 1090                 1095             


Leu Asn  Thr Leu Asp Gly Leu  Leu His Leu Met Asp  Gln Pro Leu 
    1100                 1105                 1110             


Ser Val  Asp Glu Glu Gly Leu  Val Leu Leu Glu Gln  Lys Leu Ser 
    1115                 1120                 1125             


Arg Ala  Lys Thr Gln Ile Asn  Ser Gln Leu Arg Pro  Met Met Ser 
    1130                 1135                 1140             


Glu Leu  Glu Glu Arg Ala Arg  Gln Gln Arg Gly His  Leu His Leu 
    1145                 1150                 1155             


Leu Glu  Thr Ser Ile Asp Gly  Ile Leu Ala Asp Val  Lys Asn Leu 
    1160                 1165                 1170             


Glu Asn  Ile Arg Asp Asn Leu  Pro Pro Gly Cys Tyr  Asn Thr Gln 
    1175                 1180                 1185             


Ala Leu  Glu Gln Gln 
    1190             


<210>  6
<211>  431
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Urokinase-type plasminogen activator (PLAU)

<400>  6

Met Arg Ala Leu Leu Ala Arg Leu Leu Leu Cys Val Leu Val Val Ser 
1               5                   10                  15      


Asp Ser Lys Gly Ser Asn Glu Leu His Gln Val Pro Ser Asn Cys Asp 
            20                  25                  30          


Cys Leu Asn Gly Gly Thr Cys Val Ser Asn Lys Tyr Phe Ser Asn Ile 
        35                  40                  45              


His Trp Cys Asn Cys Pro Lys Lys Phe Gly Gly Gln His Cys Glu Ile 
    50                  55                  60                  


Asp Lys Ser Lys Thr Cys Tyr Glu Gly Asn Gly His Phe Tyr Arg Gly 
65                  70                  75                  80  


Lys Ala Ser Thr Asp Thr Met Gly Arg Pro Cys Leu Pro Trp Asn Ser 
                85                  90                  95      


Ala Thr Val Leu Gln Gln Thr Tyr His Ala His Arg Ser Asp Ala Leu 
            100                 105                 110         


Gln Leu Gly Leu Gly Lys His Asn Tyr Cys Arg Asn Pro Asp Asn Arg 
        115                 120                 125             


Arg Arg Pro Trp Cys Tyr Val Gln Val Gly Leu Lys Pro Leu Val Gln 
    130                 135                 140                 


Glu Cys Met Val His Asp Cys Ala Asp Gly Lys Lys Pro Ser Ser Pro 
145                 150                 155                 160 


Pro Glu Glu Leu Lys Phe Gln Cys Gly Gln Lys Thr Leu Arg Pro Arg 
                165                 170                 175     


Phe Lys Ile Ile Gly Gly Glu Phe Thr Thr Ile Glu Asn Gln Pro Trp 
            180                 185                 190         


Phe Ala Ala Ile Tyr Arg Arg His Arg Gly Gly Ser Val Thr Tyr Val 
        195                 200                 205             


Cys Gly Gly Ser Leu Ile Ser Pro Cys Trp Val Ile Ser Ala Thr His 
    210                 215                 220                 


Cys Phe Ile Asp Tyr Pro Lys Lys Glu Asp Tyr Ile Val Tyr Leu Gly 
225                 230                 235                 240 


Arg Ser Arg Leu Asn Ser Asn Thr Gln Gly Glu Met Lys Phe Glu Val 
                245                 250                 255     


Glu Asn Leu Ile Leu His Lys Asp Tyr Ser Ala Asp Thr Leu Ala His 
            260                 265                 270         


His Asn Asp Ile Ala Leu Leu Lys Ile Arg Ser Lys Glu Gly Arg Cys 
        275                 280                 285             


Ala Gln Pro Ser Arg Thr Ile Gln Thr Ile Cys Leu Pro Ser Met Tyr 
    290                 295                 300                 


Asn Asp Pro Gln Phe Gly Thr Ser Cys Glu Ile Thr Gly Phe Gly Lys 
305                 310                 315                 320 


Glu Asn Ser Thr Asp Tyr Leu Tyr Pro Glu Gln Leu Lys Met Thr Val 
                325                 330                 335     


Val Lys Leu Ile Ser His Arg Glu Cys Gln Gln Pro His Tyr Tyr Gly 
            340                 345                 350         


Ser Glu Val Thr Thr Lys Met Leu Cys Ala Ala Asp Pro Gln Trp Lys 
        355                 360                 365             


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Ser Leu 
    370                 375                 380                 


Gln Gly Arg Met Thr Leu Thr Gly Ile Val Ser Trp Gly Arg Gly Cys 
385                 390                 395                 400 


Ala Leu Lys Asp Lys Pro Gly Val Tyr Thr Arg Val Ser His Phe Leu 
                405                 410                 415     


Pro Trp Ile Arg Ser His Thr Lys Glu Glu Asn Gly Leu Ala Leu 
            420                 425                 430     


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA sequence FSTL1

<400>  7
cggatactat tgatgaataa                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA sequence LAMC2

<400>  8
agaatcctga cattgagtgt                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA sequence DIAPH1

<400>  9
ctgcatgtga ggagttacgt                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA sequence PLAU

<400>  10
aattctaccg actatctcta                                                   20


<210>  11
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence of Pre-miR-198 WT probe

<400>  11
tcattggtcc agaggggaga taggttcctg tgatttttcc ttcttctcta tagaataaat       60

ga                                                                      62


<210>  12
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence of Pre-miR-198 WT probe

<400>  12
tcattggtcc agaggggaga taggttcctg tgaccccccc ttcttctcta tagaataaat       60

ga                                                                      62


<210>  13
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Luciferase T7 forward primer (binds 9 base pairs upstream of 
       Luciferase AUG in pMIRGLO. Includes the Kozak sequence)

<400>  13
taatacgact cactataggg aaagccacca tggaagatgc c                           41


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FSTL1 3' UTR reverse primer (Binds to position 2617 in FSTL1 
       3'UTR)

<400>  14
ccgaaaagga agaatcagga g                                                 21


<210>  15
<211>  41
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CopGFP start T7F primer

<400>  15
taatacgact cactataggg ctagacgcca ccatggagag c                           41


<210>  16
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CopGFP stop R

<400>  16
gtcgacttag cgagatccgg tg                                                22


<210>  17
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Human microRNA-198 (miRNA-198) - RNA sequence

<400>  17
gguccagagg ggagauaggu uc                                                22


<210>  18
<211>  8
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Human microRNA-198 (miRNA-198)  - Seed sequence

<400>  18
guccagag                                                                 8


<210>  19
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pre-miR-198 WT

<400>  19
tcattggtcc agaggggaga taggttcctg tgatttttcc ttcttctcta tagaataaat       60

ga                                                                      62


<210>  20
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pre-miR-198 Mut

<400>  20
tcattggtcc agaggggaga taggttcctg tgaccccccc ttcttctcta tagaataaat       60

ga                                                                      62


