                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  PRL3 Antibody

<130>  FJS/FP7283633

<150>  SG10201604834P
<151>  2016-06-14

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC-CDR1

<400>  1

Gly Tyr Thr Phe Thr Asn Tyr Tyr Met His 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC-CDR2

<400>  2

Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC-CDR3

<400>  3

Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr 
1               5                   10  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC-CDR1

<400>  4

Lys Ala Ser Gln Ser Val Glu Asp Asp Gly Glu Asn Tyr Met Asn 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC-CDR2

<400>  5

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC-CDR3

<400>  6

Gln Gln Ser Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain protein HZD_K1

<400>  7

Asp Thr Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Cys Lys Ala Ser Gln Ser Val Glu Asp Asp Gly 
            20                  25                  30          


Glu Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain protein HZD_K2

<400>  8

Asp Thr Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Cys Lys Ala Ser Gln Ser Val Glu Asp Asp Gly 
            20                  25                  30          


Glu Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  9
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain protein HZD_K3

<400>  9

Asp Thr Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Cys Lys Ala Ser Gln Ser Val Glu Asp Asp Gly 
            20                  25                  30          


Glu Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  10
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain protein HZD_K4

<400>  10

Asp Thr Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Cys Lys Ala Ser Gln Ser Val Glu Asp Asp Gly 
            20                  25                  30          


Glu Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  11
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain protein HZD_K5

<400>  11

Asp Thr Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Cys Lys Ala Ser Gln Ser Val Glu Asp Asp Gly 
            20                  25                  30          


Glu Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  12
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain protein HZD_K6

<400>  12

Asp Thr Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Cys Lys Ala Ser Gln Ser Val Glu Asp Asp Gly 
            20                  25                  30          


Glu Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  13
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain protein K

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Glu Asp Asp 
            20                  25                  30          


Gly Glu Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr 
    


<210>  14
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain protein L1

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Glu Asp Asp 
            20                  25                  30          


Gly Glu Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105                 110         


Thr 
    


<210>  15
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain protein L2

<400>  15

Asp Thr Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Glu Asp Asp 
            20                  25                  30          


Gly Glu Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105                 110         


Thr 
    


<210>  16
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain proten HZD_H1

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Leu Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe Arg 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
                85                  90                  95      


Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Ser 
        115 


<210>  17
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain protein HZD_H2

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Leu Glu Trp Ile Gly 
        35                  40                  45              


Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe Arg 
    50                  55                  60                  


Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
                85                  90                  95      


Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Ser 
        115 


<210>  18
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain protein HZD_H3

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Leu Glu Trp Ile Gly 
        35                  40                  45              


Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe Arg 
    50                  55                  60                  


Gly Arg Ala Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
                85                  90                  95      


Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Ser 
        115 


<210>  19
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain protein HZD_H4

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Leu Glu Trp Ile Gly 
        35                  40                  45              


Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe Arg 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
                85                  90                  95      


Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Ser 
        115 


<210>  20
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain protein HZD_H5

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Gly Gln Leu Glu Trp Ile Gly 
        35                  40                  45              


Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe Arg 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
                85                  90                  95      


Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Ser 
        115 


<210>  21
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain protein HZD_H6

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Arg Pro Gly Gln Leu Glu Trp Ile Gly 
        35                  40                  45              


Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe Arg 
    50                  55                  60                  


Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
                85                  90                  95      


Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Ser 
        115 


<210>  22
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain protein HZD_H7

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Ser 
        115         


<210>  23
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain protein H1

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120     


<210>  24
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain protein H2

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120     


<210>  25
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain protein H3

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120     


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Important light chain domain sequence

<400>  26

Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Important light chain domain sequence

<400>  27

Lys Ala Ser Gln Ser Val Glu Asp Asp Gly Glu Asn Tyr Met Asn Trp 
1               5                   10                  15      


Tyr Gln Gln Lys 
            20  


<210>  28
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Important light chain domain sequence

<400>  28

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
1               5                   10                  15      


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp 
            20                  25                  30          


Pro Phe Thr 
        35  


<210>  29
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Important heavy chain domain sequence

<400>  29

Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
1               5                   10                  15      


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Tyr Met His Trp 
            20                  25                  30          


Val 
    


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Important heavy chain domain sequence

<400>  30

Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Important heavy chain domain sequence

<400>  31

Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
1               5                   10                  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Important heavy chain domain sequence

<400>  32

Ala Ser Glu Glu Lys Asn Tyr Pro Trp Phe Ala Tyr Trp Gly Gln Gly 
1               5                   10                  15      


Thr Leu Val Thr 
            20  


<210>  33
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 223 heavy chain variable region

<400>  33

Glu Phe Met Glu Trp Ser Trp Val Ile Leu Phe Leu Leu Ser Ile Ile 
1               5                   10                  15      


Ala Gly Val His Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Arg Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Ser Glu Glu Arg Asn Tyr Pro Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Pro Val Tyr Pro Leu Val Pro Gly Ser Leu Gly 
145                 150                 155         


<210>  34
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 223 light chain variable region

<400>  34

Trp Glu Phe Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu 
1               5                   10                  15      


Trp Val Pro Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala 
        35                  40                  45              


Ser Gln Ser Val Glu Asp Asp Gly Glu Asn Tyr Met Asn Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn 
65                  70                  75                  80  


Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Phe Thr Phe Gly Ser Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
    130                 135                 140                 


Phe Pro Pro Ser Ser Lys Leu Gly 
145                 150         


<210>  35
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 318 heavy chain variable region

<400>  35

Glu Phe Met Glu Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Ile Ile 
1               5                   10                  15      


Ala Gly Val His Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Tyr Met His Trp Val Lys Gln Arg Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Tyr 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Arg Ala Arg Pro His Leu Gln Thr Asn Pro Pro 
                85                  90                  95      


Ala Gln Pro Thr Cys Ser Ser Ala Ala Pro Leu Arg Thr Leu Arg Ser 
            100                 105                 110         


Ile Ser Val Gln Val Arg Arg Glu Leu Pro Leu Val Cys Leu Leu Gly 
        115                 120                 125             


Pro Arg Asp Ser Gly His Cys Leu Cys Ser Gln Asn Asp Thr Pro Ile 
    130                 135                 140                 


Arg Leu Ser Pro Gly Pro Trp Lys Leu Gly 
145                 150                 


<210>  36
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Monoclonal antibody 318 light chain variable region

<400>  36

Leu Val Asp Met Glu Ser Asp Thr Leu Leu Leu Trp Val Leu Leu Leu 
1               5                   10                  15      


Trp Val Pro Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Tyr Arg Ala 
        35                  40                  45              


Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Asn Gln 
    50                  55                  60                  


Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn 
65                  70                  75                  80  


Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln His Ile Arg Glu Leu Thr Arg Ser Glu Gly Gly Pro 
        115                 120                 125             


Ser Trp Lys 
    130     


<210>  37
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human PRL3 sequence

<400>  37

Met Ala Arg Met Asn Arg Pro Ala Pro Val Glu Val Ser Tyr Lys His 
1               5                   10                  15      


Met Arg Phe Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Ser Thr 
            20                  25                  30          


Phe Ile Glu Asp Leu Lys Lys Tyr Gly Ala Thr Thr Val Val Arg Val 
        35                  40                  45              


Cys Glu Val Thr Tyr Asp Lys Thr Pro Leu Glu Lys Asp Gly Ile Thr 
    50                  55                  60                  


Val Val Asp Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Gly Lys Val 
65                  70                  75                  80  


Val Glu Asp Trp Leu Ser Leu Val Lys Ala Lys Phe Cys Glu Ala Pro 
                85                  90                  95      


Gly Ser Cys Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro 
            100                 105                 110         


Val Leu Val Ala Leu Ala Leu Ile Glu Ser Gly Met Lys Tyr Glu Asp 
        115                 120                 125             


Ala Ile Gln Phe Ile Arg Gln Lys Arg Arg Gly Ala Ile Asn Ser Lys 
    130                 135                 140                 


Gln Leu Thr Tyr Leu Glu Lys Tyr Arg Pro Lys Gln Arg Leu Arg Phe 
145                 150                 155                 160 


Lys Asp Pro His Thr His Lys Thr Arg Cys Cys Val Met 
                165                 170             


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding sequence

<400>  38

Lys Ala Lys Phe Tyr Asn 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding sequence

<400>  39

His Thr His Lys Thr Arg 
1               5       


