                         SEQUENCE LISTING

<110>  Uniwersytet Wrocawski
 
<120>  Human fibroblast growth factor 2 (FGF2) -cytotoxic drug 
       conjugates for targeted therapy of FGFR-related cancers

<130>  PZ/4039/PCT/AR

<150>  P.417544
<151>  2016-06-13

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  2
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Cys Lys Ser Gly Gly Ala Ala Gly Ser Ile Thr Thr Leu Pro 
1               5                   10                  15      


Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe 
            20                  25                  30          


Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg 
        35                  40                  45              


Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro 
    50                  55                  60                  


His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile 
65                  70                  75                  80  


Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg 
                85                  90                  95      


Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg 
            100                 105                 110         


Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser 
        115                 120                 125             


Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys 
    130                 135                 140                 


Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys 
145                 150                 155                 160 


Ser 
    


<210>  3
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser Gly Gly Ser Lys Cys 
145                 150                 155                 160 


Lys 
    


<210>  4
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Cys Lys Ser Gly Gly Ala Ala Gly Ser Ile Thr Thr Leu Pro 
1               5                   10                  15      


Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe 
            20                  25                  30          


Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg 
        35                  40                  45              


Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro 
    50                  55                  60                  


His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile 
65                  70                  75                  80  


Lys Gly Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg 
                85                  90                  95      


Leu Leu Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Glu Arg 
            100                 105                 110         


Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser 
        115                 120                 125             


Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys 
    130                 135                 140                 


Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys 
145                 150                 155                 160 


Ser 
    


<210>  5
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Ser Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Ser 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser Gly Gly Ser Lys Cys 
145                 150                 155                 160 


Lys 
    


<210>  6
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly 
1               5                   10                  15      


Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu 
            20                  25                  30          


Lys Ser Asp Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly 
        35                  40                  45              


Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys 
    50                  55                  60                  


Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe 
65                  70                  75                  80  


Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg 
                85                  90                  95      


Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys 
            100                 105                 110         


Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro 
        115                 120                 125             


Met Ser Ala Lys Ser 
    130             


<210>  7
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly 
1               5                   10                  15      


Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu 
            20                  25                  30          


Lys Ser Asp Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly 
        35                  40                  45              


Val Val Ser Ile Lys Gly Val Ser Ala Asn Arg Tyr Leu Ala Met Lys 
    50                  55                  60                  


Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe 
65                  70                  75                  80  


Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg 
                85                  90                  95      


Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys 
            100                 105                 110         


Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro 
        115                 120                 125             


Met Ser Ala Lys Ser 
    130             


<210>  8
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly 
1               5                   10                  15      


Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu 
            20                  25                  30          


Lys Ser Asp Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly 
        35                  40                  45              


Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys 
    50                  55                  60                  


Glu Asp Gly Arg Leu Leu Ala Ser Lys Ser Val Thr Asp Glu Cys Phe 
65                  70                  75                  80  


Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg 
                85                  90                  95      


Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys 
            100                 105                 110         


Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro 
        115                 120                 125             


Met Ser Ala Lys Ser 
    130             


<210>  9
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly 
1               5                   10                  15      


Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu 
            20                  25                  30          


Lys Ser Asp Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly 
        35                  40                  45              


Val Val Ser Ile Lys Gly Val Ser Ala Asn Arg Tyr Leu Ala Met Lys 
    50                  55                  60                  


Glu Asp Gly Arg Leu Leu Ala Ser Lys Ser Val Thr Asp Glu Cys Phe 
65                  70                  75                  80  


Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg 
                85                  90                  95      


Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys 
            100                 105                 110         


Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro 
        115                 120                 125             


Met Ser Ala Lys Ser 
    130             


