                         SEQUENCE LISTING

<110>  Oxford University Innovation Limited
 
<120>  ADENO-ASSOCIATED VIRAL VECTOR SYSTEM

<130>  P107080PCT

<150>  GB 1610448.1
<151>  2016-06-15

<150>  GB 1707261.2
<151>  2017-05-05

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  7326
<212>  DNA
<213>  Homo sapiens

<400>  1
aggacacagc gtccggagcc agaggcgctc ttaacggcgt ttatgtcctt tgctgtctga       60

ggggcctcag ctctgaccaa tctggtcttc gtgtggtcat tagcatgggc ttcgtgagac      120

agatacagct tttgctctgg aagaactgga ccctgcggaa aaggcaaaag attcgctttg      180

tggtggaact cgtgtggcct ttatctttat ttctggtctt gatctggtta aggaatgcca      240

acccgctcta cagccatcat gaatgccatt tccccaacaa ggcgatgccc tcagcaggaa      300

tgctgccgtg gctccagggg atcttctgca atgtgaacaa tccctgtttt caaagcccca      360

ccccaggaga atctcctgga attgtgtcaa actataacaa ctccatcttg gcaagggtat      420

atcgagattt tcaagaactc ctcatgaatg caccagagag ccagcacctt ggccgtattt      480

ggacagagct acacatcttg tcccaattca tggacaccct ccggactcac ccggagagaa      540

ttgcaggaag aggaatacga ataagggata tcttgaaaga tgaagaaaca ctgacactat      600

ttctcattaa aaacatcggc ctgtctgact cagtggtcta ccttctgatc aactctcaag      660

tccgtccaga gcagttcgct catggagtcc cggacctggc gctgaaggac atcgcctgca      720

gcgaggccct cctggagcgc ttcatcatct tcagccagag acgcggggca aagacggtgc      780

gctatgccct gtgctccctc tcccagggca ccctacagtg gatagaagac actctgtatg      840

ccaacgtgga cttcttcaag ctcttccgtg tgcttcccac actcctagac agccgttctc      900

aaggtatcaa tctgagatct tggggaggaa tattatctga tatgtcacca agaattcaag      960

agtttatcca tcggccgagt atgcaggact tgctgtgggt gaccaggccc ctcatgcaga     1020

atggtggtcc agagaccttt acaaagctga tgggcatcct gtctgacctc ctgtgtggct     1080

accccgaggg aggtggctct cgggtgctct ccttcaactg gtatgaagac aataactata     1140

aggcctttct ggggattgac tccacaagga aggatcctat ctattcttat gacagaagaa     1200

caacatcctt ttgtaatgca ttgatccaga gcctggagtc aaatccttta accaaaatcg     1260

cttggagggc ggcaaagcct ttgctgatgg gaaaaatcct gtacactcct gattcacctg     1320

cagcacgaag gatactgaag aatgccaact caacttttga agaactggaa cacgttagga     1380

agttggtcaa agcctgggaa gaagtagggc cccagatctg gtacttcttt gacaacagca     1440

cacagatgaa catgatcaga gataccctgg ggaacccaac agtaaaagac tttttgaata     1500

ggcagcttgg tgaagaaggt attactgctg aagccatcct aaacttcctc tacaagggcc     1560

ctcgggaaag ccaggctgac gacatggcca acttcgactg gagggacata tttaacatca     1620

ctgatcgcac cctccgcctg gtcaatcaat acctggagtg cttggtcctg gataagtttg     1680

aaagctacaa tgatgaaact cagctcaccc aacgtgccct ctctctactg gaggaaaaca     1740

tgttctgggc cggagtggta ttccctgaca tgtatccctg gaccagctct ctaccacccc     1800

acgtgaagta taagatccga atggacatag acgtggtgga gaaaaccaat aagattaaag     1860

acaggtattg ggattctggt cccagagctg atcccgtgga agatttccgg tacatctggg     1920

gcgggtttgc ctatctgcag gacatggttg aacaggggat cacaaggagc caggtgcagg     1980

cggaggctcc agttggaatc tacctccagc agatgcccta cccctgcttc gtggacgatt     2040

ctttcatgat catcctgaac cgctgtttcc ctatcttcat ggtgctggca tggatctact     2100

ctgtctccat gactgtgaag agcatcgtct tggagaagga gttgcgactg aaggagacct     2160

tgaaaaatca gggtgtctcc aatgcagtga tttggtgtac ctggttcctg gacagcttct     2220

ccatcatgtc gatgagcatc ttcctcctga cgatattcat catgcatgga agaatcctac     2280

attacagcga cccattcatc ctcttcctgt tcttgttggc tttctccact gccaccatca     2340

tgctgtgctt tctgctcagc accttcttct ccaaggccag tctggcagca gcctgtagtg     2400

gtgtcatcta tttcaccctc tacctgccac acatcctgtg cttcgcctgg caggaccgca     2460

tgaccgctga gctgaagaag gctgtgagct tactgtctcc ggtggcattt ggatttggca     2520

ctgagtacct ggttcgcttt gaagagcaag gcctggggct gcagtggagc aacatcggga     2580

acagtcccac ggaaggggac gaattcagct tcctgctgtc catgcagatg atgctccttg     2640

atgctgctgt ctatggctta ctcgcttggt accttgatca ggtgtttcca ggagactatg     2700

gaaccccact tccttggtac tttcttctac aagagtcgta ttggcttggc ggtgaagggt     2760

gttcaaccag agaagaaaga gccctggaaa agaccgagcc cctaacagag gaaacggagg     2820

atccagagca cccagaagga atacacgact ccttctttga acgtgagcat ccagggtggg     2880

ttcctggggt atgcgtgaag aatctggtaa agatttttga gccctgtggc cggccagctg     2940

tggaccgtct gaacatcacc ttctacgaga accagatcac cgcattcctg ggccacaatg     3000

gagctgggaa aaccaccacc ttgtccatcc tgacgggtct gttgccacca acctctggga     3060

ctgtgctcgt tgggggaagg gacattgaaa ccagcctgga tgcagtccgg cagagccttg     3120

gcatgtgtcc acagcacaac atcctgttcc accacctcac ggtggctgag cacatgctgt     3180

tctatgccca gctgaaagga aagtcccagg aggaggccca gctggagatg gaagccatgt     3240

tggaggacac aggcctccac cacaagcgga atgaagaggc tcaggaccta tcaggtggca     3300

tgcagagaaa gctgtcggtt gccattgcct ttgtgggaga tgccaaggtg gtgattctgg     3360

acgaacccac ctctggggtg gacccttact cgagacgctc aatctgggat ctgctcctga     3420

agtatcgctc aggcagaacc atcatcatgt ccactcacca catggacgag gccgacctcc     3480

ttggggaccg cattgccatc attgcccagg gaaggctcta ctgctcaggc accccactct     3540

tcctgaagaa ctgctttggc acaggcttgt acttaacctt ggtgcgcaag atgaaaaaca     3600

tccagagcca aaggaaaggc agtgagggga cctgcagctg ctcgtctaag ggtttctcca     3660

ccacgtgtcc agcccacgtc gatgacctaa ctccagaaca agtcctggat ggggatgtaa     3720

atgagctgat ggatgtagtt ctccaccatg ttccagaggc aaagctggtg gagtgcattg     3780

gtcaagaact tatcttcctt cttccaaata agaacttcaa gcacagagca tatgccagcc     3840

ttttcagaga gctggaggag acgctggctg accttggtct cagcagtttt ggaatttctg     3900

acactcccct ggaagagatt tttctgaagg tcacggagga ttctgattca ggacctctgt     3960

ttgcgggtgg cgctcagcag aaaagagaaa acgtcaaccc ccgacacccc tgcttgggtc     4020

ccagagagaa ggctggacag acaccccagg actccaatgt ctgctcccca ggggcgccgg     4080

ctgctcaccc agagggccag cctcccccag agccagagtg cccaggcccg cagctcaaca     4140

cggggacaca gctggtcctc cagcatgtgc aggcgctgct ggtcaagaga ttccaacaca     4200

ccatccgcag ccacaaggac ttcctggcgc agatcgtgct cccggctacc tttgtgtttt     4260

tggctctgat gctttctatt gttatccctc cttttggcga ataccccgct ttgacccttc     4320

acccctggat atatgggcag cagtacacct tcttcagcat ggatgaacca ggcagtgagc     4380

agttcacggt acttgcagac gtcctcctga ataagccagg ctttggcaac cgctgcctga     4440

aggaagggtg gcttccggag tacccctgtg gcaactcaac accctggaag actccttctg     4500

tgtccccaaa catcacccag ctgttccaga agcagaaatg gacacaggtc aacccttcac     4560

catcctgcag gtgcagcacc agggagaagc tcaccatgct gccagagtgc cccgagggtg     4620

ccgggggcct cccgcccccc cagagaacac agcgcagcac ggaaattcta caagacctga     4680

cggacaggaa catctccgac ttcttggtaa aaacgtatcc tgctcttata agaagcagct     4740

taaagagcaa attctgggtc aatgaacaga ggtatggagg aatttccatt ggaggaaagc     4800

tcccagtcgt ccccatcacg ggggaagcac ttgttgggtt tttaagcgac cttggccgga     4860

tcatgaatgt gagcgggggc cctatcacta gagaggcctc taaagaaata cctgatttcc     4920

ttaaacatct agaaactgaa gacaacatta aggtgtggtt taataacaaa ggctggcatg     4980

ccctggtcag ctttctcaat gtggcccaca acgccatctt acgggccagc ctgcctaagg     5040

acaggagccc cgaggagtat ggaatcaccg tcattagcca acccctgaac ctgaccaagg     5100

agcagctctc agagattaca gtgctgacca cttcagtgga tgctgtggtt gccatctgcg     5160

tgattttctc catgtccttc gtcccagcca gctttgtcct ttatttgatc caggagcggg     5220

tgaacaaatc caagcacctc cagtttatca gtggagtgag ccccaccacc tactgggtga     5280

ccaacttcct ctgggacatc atgaattatt ccgtgagtgc tgggctggtg gtgggcatct     5340

tcatcgggtt tcagaagaaa gcctacactt ctccagaaaa ccttcctgcc cttgtggcac     5400

tgctcctgct gtatggatgg gcggtcattc ccatgatgta cccagcatcc ttcctgtttg     5460

atgtccccag cacagcctat gtggctttat cttgtgctaa tctgttcatc ggcatcaaca     5520

gcagtgctat taccttcatc ttggaattat ttgagaataa ccggacgctg ctcaggttca     5580

acgccgtgct gaggaagctg ctcattgtct tcccccactt ctgcctgggc cggggcctca     5640

ttgaccttgc actgagccag gctgtgacag atgtctatgc ccggtttggt gaggagcact     5700

ctgcaaatcc gttccactgg gacctgattg ggaagaacct gtttgccatg gtggtggaag     5760

gggtggtgta cttcctcctg accctgctgg tccagcgcca cttcttcctc tcccaatgga     5820

ttgccgagcc cactaaggag cccattgttg atgaagatga tgatgtggct gaagaaagac     5880

aaagaattat tactggtgga aataaaactg acatcttaag gctacatgaa ctaaccaaga     5940

tttatccagg cacctccagc ccagcagtgg acaggctgtg tgtcggagtt cgccctggag     6000

agtgctttgg cctcctggga gtgaatggtg ccggcaaaac aaccacattc aagatgctca     6060

ctggggacac cacagtgacc tcaggggatg ccaccgtagc aggcaagagt attttaacca     6120

atatttctga agtccatcaa aatatgggct actgtcctca gtttgatgca attgatgagc     6180

tgctcacagg acgagaacat ctttaccttt atgcccggct tcgaggtgta ccagcagaag     6240

aaatcgaaaa ggttgcaaac tggagtatta agagcctggg cctgactgtc tacgccgact     6300

gcctggctgg cacgtacagt gggggcaaca agcggaaact ctccacagcc atcgcactca     6360

ttggctgccc accgctggtg ctgctggatg agcccaccac agggatggac ccccaggcac     6420

gccgcatgct gtggaacgtc atcgtgagca tcatcagaga agggagggct gtggtcctca     6480

catcccacag catggaagaa tgtgaggcac tgtgtacccg gctggccatc atggtaaagg     6540

gcgcctttcg atgtatgggc accattcagc atctcaagtc caaatttgga gatggctata     6600

tcgtcacaat gaagatcaaa tccccgaagg acgacctgct tcctgacctg aaccctgtgg     6660

agcagttctt ccaggggaac ttcccaggca gtgtgcagag ggagaggcac tacaacatgc     6720

tccagttcca ggtctcctcc tcctccctgg cgaggatctt ccagctcctc ctctcccaca     6780

aggacagcct gctcatcgag gagtactcag tcacacagac cacactggac caggtgtttg     6840

taaattttgc taaacagcag actgaaagtc atgacctccc tctgcaccct cgagctgctg     6900

gagccagtcg acaagcccag gactgatctt tcacaccgct cgttcctgca gccagaaagg     6960

aactctgggc agctggaggc gcaggagcct gtgcccatat ggtcatccaa atggactggc     7020

cagcgtaaat gaccccactg cagcagaaaa caaacacacg aggagcatgc agcgaattca     7080

gaaagaggtc tttcagaagg aaaccgaaac tgacttgctc acctggaaca cctgatggtg     7140

aaaccaaaca aatacaaaat ccttctccag accccagaac tagaaacccc gggccatccc     7200

actagcagct ttggcctcca tattgctctc atttcaagca gatctgcttt tctgcatgtt     7260

tgtctgtgtg tctgcgttgt gtgtgatttt catggaaaaa taaaatgcaa atgcactcat     7320

cacaaa                                                                7326


<210>  2
<211>  7326
<212>  DNA
<213>  Homo sapiens

<400>  2
aggacacagc gtccggagcc agaggcgctc ttaacggcgt ttatgtcctt tgctgtctga       60

ggggcctcag ctctgaccaa tctggtcttc gtgtggtcat tagcatgggc ttcgtgagac      120

agatacagct tttgctctgg aagaactgga ccctgcggaa aaggcaaaag attcgctttg      180

tggtggaact cgtgtggcct ttatctttat ttctggtctt gatctggtta aggaatgcca      240

acccgctcta cagccatcat gaatgccatt tccccaacaa ggcgatgccc tcagcaggaa      300

tgctgccgtg gctccagggg atcttctgca atgtgaacaa tccctgtttt caaagcccca      360

ccccaggaga atctcctgga attgtgtcaa actataacaa ctccatcttg gcaagggtat      420

atcgagattt tcaagaactc ctcatgaatg caccagagag ccagcacctt ggccgtattt      480

ggacagagct acacatcttg tcccaattca tggacaccct ccggactcac ccggagagaa      540

ttgcaggaag aggaatacga ataagggata tcttgaaaga tgaagaaaca ctgacactat      600

ttctcattaa aaacatcggc ctgtctgact cagtggtcta ccttctgatc aactctcaag      660

tccgtccaga gcagttcgct catggagtcc cggacctggc gctgaaggac atcgcctgca      720

gcgaggccct cctggagcgc ttcatcatct tcagccagag acgcggggca aagacggtgc      780

gctatgccct gtgctccctc tcccagggca ccctacagtg gatagaagac actctgtatg      840

ccaacgtgga cttcttcaag ctcttccgtg tgcttcccac actcctagac agccgttctc      900

aaggtatcaa tctgagatct tggggaggaa tattatctga tatgtcacca agaattcaag      960

agtttatcca tcggccgagt atgcaggact tgctgtgggt gaccaggccc ctcatgcaga     1020

atggtggtcc agagaccttt acaaagctga tgggcatcct gtctgacctc ctgtgtggct     1080

accccgaggg aggtggctct cgggtgctct ccttcaactg gtatgaagac aataactata     1140

aggcctttct ggggattgac tccacaagga aggatcctat ctattcttat gacagaagaa     1200

caacatcctt ttgtaatgca ttgatccaga gcctggagtc aaatccttta accaaaatcg     1260

cttggagggc ggcaaagcct ttgctgatgg gaaaaatcct gtacactcct gattcacctg     1320

cagcacgaag gatactgaag aatgccaact caacttttga agaactggaa cacgttagga     1380

agttggtcaa agcctgggaa gaagtagggc cccagatctg gtacttcttt gacaacagca     1440

cacagatgaa catgatcaga gataccctgg ggaacccaac agtaaaagac tttttgaata     1500

ggcagcttgg tgaagaaggt attactgctg aagccatcct aaacttcctc tacaagggcc     1560

ctcgggaaag ccaggctgac gacatggcca acttcgactg gagggacata tttaacatca     1620

ctgatcgcac cctccgcctt gtcaatcaat acctggagtg cttggtcctg gataagtttg     1680

aaagctacaa tgatgaaact cagctcaccc aacgtgccct ctctctactg gaggaaaaca     1740

tgttctgggc cggagtggta ttccctgaca tgtatccctg gaccagctct ctaccacccc     1800

acgtgaagta taagatccga atggacatag acgtggtgga gaaaaccaat aagattaaag     1860

acaggtattg ggattctggt cccagagctg atcccgtgga agatttccgg tacatctggg     1920

gcgggtttgc ctatctgcag gacatggttg aacaggggat cacaaggagc caggtgcagg     1980

cggaggctcc agttggaatc tacctccagc agatgcccta cccctgcttc gtggacgatt     2040

ctttcatgat catcctgaac cgctgtttcc ctatcttcat ggtgctggca tggatctact     2100

ctgtctccat gactgtgaag agcatcgtct tggagaagga gttgcgactg aaggagacct     2160

tgaaaaatca gggtgtctcc aatgcagtga tttggtgtac ctggttcctg gacagcttct     2220

ccatcatgtc gatgagcatc ttcctcctga cgatattcat catgcatgga agaatcctac     2280

attacagcga cccattcatc ctcttcctgt tcttgttggc tttctccact gccaccatca     2340

tgctgtgctt tctgctcagc accttcttct ccaaggccag tctggcagca gcctgtagtg     2400

gtgtcatcta tttcaccctc tacctgccac acatcctgtg cttcgcctgg caggaccgca     2460

tgaccgctga gctgaagaag gctgtgagct tactgtctcc ggtggcattt ggatttggca     2520

ctgagtacct ggttcgcttt gaagagcaag gcctggggct gcagtggagc aacatcggga     2580

acagtcccac ggaaggggac gaattcagct tcctgctgtc catgcagatg atgctccttg     2640

atgctgctgt ctatggctta ctcgcttggt accttgatca ggtgtttcca ggagactatg     2700

gaaccccact tccttggtac tttcttctac aagagtcgta ttggcttggc ggtgaagggt     2760

gttcaaccag agaagaaaga gccctggaaa agaccgagcc cctaacagag gaaacggagg     2820

atccagagca cccagaagga atacacgact ccttctttga acgtgagcat ccagggtggg     2880

ttcctggggt atgcgtgaag aatctggtaa agatttttga gccctgtggc cggccagctg     2940

tggaccgtct gaacatcacc ttctacgaga accagatcac cgcattcctg ggccacaatg     3000

gagctgggaa aaccaccacc ttgtccatcc tgacgggtct gttgccacca acctctggga     3060

ctgtgctcgt tgggggaagg gacattgaaa ccagcctgga tgcagtccgg cagagccttg     3120

gcatgtgtcc acagcacaac atcctgttcc accacctcac ggtggctgag cacatgctgt     3180

tctatgccca gctgaaagga aagtcccagg aggaggccca gctggagatg gaagccatgt     3240

tggaggacac aggcctccac cacaagcgga atgaagaggc tcaggaccta tcaggtggca     3300

tgcagagaaa gctgtcggtt gccattgcct ttgtgggaga tgccaaggtg gtgattctgg     3360

acgaacccac ctctggggtg gacccttact cgagacgctc aatctgggat ctgctcctga     3420

agtatcgctc aggcagaacc atcatcatgt ccactcacca catggacgag gccgacctcc     3480

ttggggaccg cattgccatc attgcccagg gaaggctcta ctgctcaggc accccactct     3540

tcctgaagaa ctgctttggc acaggcttgt acttaacctt ggtgcgcaag atgaaaaaca     3600

tccagagcca aaggaaaggc agtgagggga cctgcagctg ctcgtctaag ggtttctcca     3660

ccacgtgtcc agcccacgtc gatgacctaa ctccagaaca agtcctggat ggggatgtaa     3720

atgagctgat ggatgtagtt ctccaccatg ttccagaggc aaagctggtg gagtgcattg     3780

gtcaagaact tatcttcctt cttccaaata agaacttcaa gcacagagca tatgccagcc     3840

ttttcagaga gctggaggag acgctggctg accttggtct cagcagtttt ggaatttctg     3900

acactcccct ggaagagatt tttctgaagg tcacggagga ttctgattca ggacctctgt     3960

ttgcgggtgg cgctcagcag aaaagagaaa acgtcaaccc ccgacacccc tgcttgggtc     4020

ccagagagaa ggctggacag acaccccagg actccaatgt ctgctcccca ggggcgccgg     4080

ctgctcaccc agagggccag cctcccccag agccagagtg cccaggcccg cagctcaaca     4140

cggggacaca gctggtcctc cagcatgtgc aggcgctgct ggtcaagaga ttccaacaca     4200

ccatccgcag ccacaaggac ttcctggcgc agatcgtgct cccggctacc tttgtgtttt     4260

tggctctgat gctttctatt gttatccctc cttttggcga ataccccgct ttgacccttc     4320

acccctggat atatgggcag cagtacacct tcttcagcat ggatgaacca ggcagtgagc     4380

agttcacggt acttgcagac gtcctcctga ataagccagg ctttggcaac cgctgcctga     4440

aggaagggtg gcttccggag tacccctgtg gcaactcaac accctggaag actccttctg     4500

tgtccccaaa catcacccag ctgttccaga agcagaaatg gacacaggtc aacccttcac     4560

catcctgcag gtgcagcacc agggagaagc tcaccatgct gccagagtgc cccgagggtg     4620

ccgggggcct cccgcccccc cagagaacac agcgcagcac ggaaattcta caagacctga     4680

cggacaggaa catctccgac ttcttggtaa aaacgtatcc tgctcttata agaagcagct     4740

taaagagcaa attctgggtc aatgaacaga ggtatggagg aatttccatt ggaggaaagc     4800

tcccagtcgt ccccatcacg ggggaagcac ttgttgggtt tttaagcgac cttggccgga     4860

tcatgaatgt gagcgggggc cctatcacta gagaggcctc taaagaaata cctgatttcc     4920

ttaaacatct agaaactgaa gacaacatta aggtgtggtt taataacaaa ggctggcatg     4980

ccctggtcag ctttctcaat gtggcccaca acgccatctt acgggccagc ctgcctaagg     5040

acaggagccc cgaggagtat ggaatcaccg tcattagcca acccctgaac ctgaccaagg     5100

agcagctctc agagattaca gtgctgacca cttcagtgga tgctgtggtt gccatctgcg     5160

tgattttctc catgtccttc gtcccagcca gctttgtcct ttatttgatc caggagcggg     5220

tgaacaaatc caagcacctc cagtttatca gtggagtgag ccccaccacc tactgggtaa     5280

ccaacttcct ctgggacatc atgaattatt ccgtgagtgc tgggctggtg gtgggcatct     5340

tcatcgggtt tcagaagaaa gcctacactt ctccagaaaa ccttcctgcc cttgtggcac     5400

tgctcctgct gtatggatgg gcggtcattc ccatgatgta cccagcatcc ttcctgtttg     5460

atgtccccag cacagcctat gtggctttat cttgtgctaa tctgttcatc ggcatcaaca     5520

gcagtgctat taccttcatc ttggaattat ttgagaataa ccggacgctg ctcaggttca     5580

acgccgtgct gaggaagctg ctcattgtct tcccccactt ctgcctgggc cggggcctca     5640

ttgaccttgc actgagccag gctgtgacag atgtctatgc ccggtttggt gaggagcact     5700

ctgcaaatcc gttccactgg gacctgattg ggaagaacct gtttgccatg gtggtggaag     5760

gggtggtgta cttcctcctg accctgctgg tccagcgcca cttcttcctc tcccaatgga     5820

ttgccgagcc cactaaggag cccattgttg atgaagatga tgatgtggct gaagaaagac     5880

aaagaattat tactggtgga aataaaactg acatcttaag gctacatgaa ctaaccaaga     5940

tttatccagg cacctccagc ccagcagtgg acaggctgtg tgtcggagtt cgccctggag     6000

agtgctttgg cctcctggga gtgaatggtg ccggcaaaac aaccacattc aagatgctca     6060

ctggggacac cacagtgacc tcaggggatg ccaccgtagc aggcaagagt attttaacca     6120

atatttctga agtccatcaa aatatgggct actgtcctca gtttgatgca atcgatgagc     6180

tgctcacagg acgagaacat ctttaccttt atgcccggct tcgaggtgta ccagcagaag     6240

aaatcgaaaa ggttgcaaac tggagtatta agagcctggg cctgactgtc tacgccgact     6300

gcctggctgg cacgtacagt gggggcaaca agcggaaact ctccacagcc atcgcactca     6360

ttggctgccc accgctggtg ctgctggatg agcccaccac agggatggac ccccaggcac     6420

gccgcatgct gtggaacgtc atcgtgagca tcatcagaga agggagggct gtggtcctca     6480

catcccacag catggaagaa tgtgaggcac tgtgtacccg gctggccatc atggtaaagg     6540

gcgcctttcg atgtatgggc accattcagc atctcaagtc caaatttgga gatggctata     6600

tcgtcacaat gaagatcaaa tccccgaagg acgacctgct tcctgacctg aaccctgtgg     6660

agcagttctt ccaggggaac ttcccaggca gtgtgcagag ggagaggcac tacaacatgc     6720

tccagttcca ggtctcctcc tcctccctgg cgaggatctt ccagctcctc ctctcccaca     6780

aggacagcct gctcatcgag gagtactcag tcacacagac cacactggac caggtgtttg     6840

taaattttgc taaacagcag actgaaagtc atgacctccc tctgcaccct cgagctgctg     6900

gagccagtcg acaagcccag gactgatctt tcacaccgct cgttcctgca gccagaaagg     6960

aactctgggc agctggaggc gcaggagcct gtgcccatat ggtcatccaa atggactggc     7020

cagcgtaaat gaccccactg cagcagaaaa caaacacacg aggagcatgc agcgaattca     7080

gaaagaggtc tttcagaagg aaaccgaaac tgacttgctc acctggaaca cctgatggtg     7140

aaaccaaaca aatacaaaat ccttctccag accccagaac tagaaacccc gggccatccc     7200

actagcagct ttggcctcca tattgctctc atttcaagca gatctgcttt tctgcatgtt     7260

tgtctgtgtg tctgcgttgt gtgtgatttt catggaaaaa taaaatgcaa atgcactcat     7320

cacaaa                                                                7326


<210>  3
<211>  4464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example upstream vector sequence, comprising ITR, promoter, CDS, 
       ITR

<400>  3
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctgcggc aattcagtcg ataactataa cggtcctaag      180

gtagcgattt aaatggtacc gggccccaga agcctggtgg ttgtttgtcc ttctcagggg      240

aaaagtgagg cggccccttg gaggaagggg ccgggcagaa tgatctaatc ggattccaag      300

cagctcaggg gattgtcttt ttctagcacc ttcttgccac tcctaagcgt cctccgtgac      360

cccggctggg atttagcctg gtgctgtgtc agccccgggt gccgcagggg gacggctgcc      420

ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc ggctctagag      480

cctctgctaa ccatgttcat gccttcttct ttttcctaca gctcctgggc aacgtgctgg      540

ttattgtgct gtctcatcat tttggcaaag aattaccacc atgggcttcg tgagacagat      600

acagcttttg ctctggaaga actggaccct gcggaaaagg caaaagattc gctttgtggt      660

ggaactcgtg tggcctttat ctttatttct ggtcttgatc tggttaagga atgccaaccc      720

gctctacagc catcatgaat gccatttccc caacaaggcg atgccctcag caggaatgct      780

gccgtggctc caggggatct tctgcaatgt gaacaatccc tgttttcaaa gccccacccc      840

aggagaatct cctggaattg tgtcaaacta taacaactcc atcttggcaa gggtatatcg      900

agattttcaa gaactcctca tgaatgcacc agagagccag caccttggcc gtatttggac      960

agagctacac atcttgtccc aattcatgga caccctccgg actcacccgg agagaattgc     1020

aggaagagga atacgaataa gggatatctt gaaagatgaa gaaacactga cactatttct     1080

cattaaaaac atcggcctgt ctgactcagt ggtctacctt ctgatcaact ctcaagtccg     1140

tccagagcag ttcgctcatg gagtcccgga cctggcgctg aaggacatcg cctgcagcga     1200

ggccctcctg gagcgcttca tcatcttcag ccagagacgc ggggcaaaga cggtgcgcta     1260

tgccctgtgc tccctctccc agggcaccct acagtggata gaagacactc tgtatgccaa     1320

cgtggacttc ttcaagctct tccgtgtgct tcccacactc ctagacagcc gttctcaagg     1380

tatcaatctg agatcttggg gaggaatatt atctgatatg tcaccaagaa ttcaagagtt     1440

tatccatcgg ccgagtatgc aggacttgct gtgggtgacc aggcccctca tgcagaatgg     1500

tggtccagag acctttacaa agctgatggg catcctgtct gacctcctgt gtggctaccc     1560

cgagggaggt ggctctcggg tgctctcctt caactggtat gaagacaata actataaggc     1620

ctttctgggg attgactcca caaggaagga tcctatctat tcttatgaca gaagaacaac     1680

atccttttgt aatgcattga tccagagcct ggagtcaaat cctttaacca aaatcgcttg     1740

gagggcggca aagcctttgc tgatgggaaa aatcctgtac actcctgatt cacctgcagc     1800

acgaaggata ctgaagaatg ccaactcaac ttttgaagaa ctggaacacg ttaggaagtt     1860

ggtcaaagcc tgggaagaag tagggcccca gatctggtac ttctttgaca acagcacaca     1920

gatgaacatg atcagagata ccctggggaa cccaacagta aaagactttt tgaataggca     1980

gcttggtgaa gaaggtatta ctgctgaagc catcctaaac ttcctctaca agggccctcg     2040

ggaaagccag gctgacgaca tggccaactt cgactggagg gacatattta acatcactga     2100

tcgcaccctc cgccttgtca atcaatacct ggagtgcttg gtcctggata agtttgaaag     2160

ctacaatgat gaaactcagc tcacccaacg tgccctctct ctactggagg aaaacatgtt     2220

ctgggccgga gtggtattcc ctgacatgta tccctggacc agctctctac caccccacgt     2280

gaagtataag atccgaatgg acatagacgt ggtggagaaa accaataaga ttaaagacag     2340

gtattgggat tctggtccca gagctgatcc cgtggaagat ttccggtaca tctggggcgg     2400

gtttgcctat ctgcaggaca tggttgaaca ggggatcaca aggagccagg tgcaggcgga     2460

ggctccagtt ggaatctacc tccagcagat gccctacccc tgcttcgtgg acgattcttt     2520

catgatcatc ctgaaccgct gtttccctat cttcatggtg ctggcatgga tctactctgt     2580

ctccatgact gtgaagagca tcgtcttgga gaaggagttg cgactgaagg agaccttgaa     2640

aaatcagggt gtctccaatg cagtgatttg gtgtacctgg ttcctggaca gcttctccat     2700

catgtcgatg agcatcttcc tcctgacgat attcatcatg catggaagaa tcctacatta     2760

cagcgaccca ttcatcctct tcctgttctt gttggctttc tccactgcca ccatcatgct     2820

gtgctttctg ctcagcacct tcttctccaa ggccagtctg gcagcagcct gtagtggtgt     2880

catctatttc accctctacc tgccacacat cctgtgcttc gcctggcagg accgcatgac     2940

cgctgagctg aagaaggctg tgagcttact gtctccggtg gcatttggat ttggcactga     3000

gtacctggtt cgctttgaag agcaaggcct ggggctgcag tggagcaaca tcgggaacag     3060

tcccacggaa ggggacgaat tcagcttcct gctgtccatg cagatgatgc tccttgatgc     3120

tgctgtctat ggcttactcg cttggtacct tgatcaggtg tttccaggag actatggaac     3180

cccacttcct tggtactttc ttctacaaga gtcgtattgg cttggcggtg aagggtgttc     3240

aaccagagaa gaaagagccc tggaaaagac cgagccccta acagaggaaa cggaggatcc     3300

agagcaccca gaaggaatac acgactcctt ctttgaacgt gagcatccag ggtgggttcc     3360

tggggtatgc gtgaagaatc tggtaaagat ttttgagccc tgtggccggc cagctgtgga     3420

ccgtctgaac atcaccttct acgagaacca gatcaccgca ttcctgggcc acaatggagc     3480

tgggaaaacc accaccttgt ccatcctgac gggtctgttg ccaccaacct ctgggactgt     3540

gctcgttggg ggaagggaca ttgaaaccag cctggatgca gtccggcaga gccttggcat     3600

gtgtccacag cacaacatcc tgttccacca cctcacggtg gctgagcaca tgctgttcta     3660

tgcccagctg aaaggaaagt cccaggagga ggcccagctg gagatggaag ccatgttgga     3720

ggacacaggc ctccaccaca agcggaatga agaggctcag gacctatcag gtggcatgca     3780

gagaaagctg tcggttgcca ttgcctttgt gggagatgcc aaggtggtga ttctggacga     3840

acccacctct ggggtggacc cttactcgag acgctcaatc tgggatctgc tcctgaagta     3900

tcgctcaggc agaaccatca tcatgtccac tcaccacatg gacgaggccg acctccttgg     3960

ggaccgcatt gccatcattg cccagggaag gctctactgc tcaggcaccc cactcttcct     4020

gaagaactgc tttggcacag gcttgtactt aaccttggtg cgcaagatga aaaacatcca     4080

gagccaaagg aaaggcagtg aggggacctg cagctgctcg tctaagggtt tctccaccac     4140

gtgtccagcc cacgtcgatg acctaactcc agaacaagtc ctggatgggg atgtaaatga     4200

gctgatggat gtagttctcc accatgttcc agaggcaaag ctggtggagt gcattggtca     4260

agaacttatc ttccttcttc catttaaatt agggataaca gggtaatggc gcgggccgca     4320

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     4380

cgcccgggca aagcccgggc gtcgggcgac ctttggtcgc ccggcctcag tgagcgagcg     4440

agcgcgcaga gagggagtgg ccaa                                            4464


<210>  4
<211>  4581
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example downstream vector sequence, comprising ITR, CDS, 
       post-transcriptional response element, poly-adenylation sequence,
       ITR

<400>  4
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctgcggc aattcagtcg ataactataa cggtcctaag      180

gtagcgattt aaataacatc cagagccaaa ggaaaggcag tgaggggacc tgcagctgct      240

cgtctaaggg tttctccacc acgtgtccag cccacgtcga tgacctaact ccagaacaag      300

tcctggatgg ggatgtaaat gagctgatgg atgtagttct ccaccatgtt ccagaggcaa      360

agctggtgga gtgcattggt caagaactta tcttccttct tccaaataag aacttcaagc      420

acagagcata tgccagcctt ttcagagagc tggaggagac gctggctgac cttggtctca      480

gcagttttgg aatttctgac actcccctgg aagagatttt tctgaaggtc acggaggatt      540

ctgattcagg acctctgttt gcgggtggcg ctcagcagaa aagagaaaac gtcaaccccc      600

gacacccctg cttgggtccc agagagaagg ctggacagac accccaggac tccaatgtct      660

gctccccagg ggcgccggct gctcacccag agggccagcc tcccccagag ccagagtgcc      720

caggcccgca gctcaacacg gggacacagc tggtcctcca gcatgtgcag gcgctgctgg      780

tcaagagatt ccaacacacc atccgcagcc acaaggactt cctggcgcag atcgtgctcc      840

cggctacctt tgtgtttttg gctctgatgc tttctattgt tatccctcct tttggcgaat      900

accccgcttt gacccttcac ccctggatat atgggcagca gtacaccttc ttcagcatgg      960

atgaaccagg cagtgagcag ttcacggtac ttgcagacgt cctcctgaat aagccaggct     1020

ttggcaaccg ctgcctgaag gaagggtggc ttccggagta cccctgtggc aactcaacac     1080

cctggaagac tccttctgtg tccccaaaca tcacccagct gttccagaag cagaaatgga     1140

cacaggtcaa cccttcacca tcctgcaggt gcagcaccag ggagaagctc accatgctgc     1200

cagagtgccc cgagggtgcc gggggcctcc cgccccccca gagaacacag cgcagcacgg     1260

aaattctaca agacctgacg gacaggaaca tctccgactt cttggtaaaa acgtatcctg     1320

ctcttataag aagcagctta aagagcaaat tctgggtcaa tgaacagagg tatggaggaa     1380

tttccattgg aggaaagctc ccagtcgtcc ccatcacggg ggaagcactt gttgggtttt     1440

taagcgacct tggccggatc atgaatgtga gcgggggccc tatcactaga gaggcctcta     1500

aagaaatacc tgatttcctt aaacatctag aaactgaaga caacattaag gtgtggttta     1560

ataacaaagg ctggcatgcc ctggtcagct ttctcaatgt ggcccacaac gccatcttac     1620

gggccagcct gcctaaggac aggagccccg aggagtatgg aatcaccgtc attagccaac     1680

ccctgaacct gaccaaggag cagctctcag agattacagt gctgaccact tcagtggatg     1740

ctgtggttgc catctgcgtg attttctcca tgtccttcgt cccagccagc tttgtccttt     1800

atttgatcca ggagcgggtg aacaaatcca agcacctcca gtttatcagt ggagtgagcc     1860

ccaccaccta ctgggtaacc aacttcctct gggacatcat gaattattcc gtgagtgctg     1920

ggctggtggt gggcatcttc atcgggtttc agaagaaagc ctacacttct ccagaaaacc     1980

ttcctgccct tgtggcactg ctcctgctgt atggatgggc ggtcattccc atgatgtacc     2040

cagcatcctt cctgtttgat gtccccagca cagcctatgt ggctttatct tgtgctaatc     2100

tgttcatcgg catcaacagc agtgctatta ccttcatctt ggaattattt gagaataacc     2160

ggacgctgct caggttcaac gccgtgctga ggaagctgct cattgtcttc ccccacttct     2220

gcctgggccg gggcctcatt gaccttgcac tgagccaggc tgtgacagat gtctatgccc     2280

ggtttggtga ggagcactct gcaaatccgt tccactggga cctgattggg aagaacctgt     2340

ttgccatggt ggtggaaggg gtggtgtact tcctcctgac cctgctggtc cagcgccact     2400

tcttcctctc ccaatggatt gccgagccca ctaaggagcc cattgttgat gaagatgatg     2460

atgtggctga agaaagacaa agaattatta ctggtggaaa taaaactgac atcttaaggc     2520

tacatgaact aaccaagatt tatccaggca cctccagccc agcagtggac aggctgtgtg     2580

tcggagttcg ccctggagag tgctttggcc tcctgggagt gaatggtgcc ggcaaaacaa     2640

ccacattcaa gatgctcact ggggacacca cagtgacctc aggggatgcc accgtagcag     2700

gcaagagtat tttaaccaat atttctgaag tccatcaaaa tatgggctac tgtcctcagt     2760

ttgatgcaat cgatgagctg ctcacaggac gagaacatct ttacctttat gcccggcttc     2820

gaggtgtacc agcagaagaa atcgaaaagg ttgcaaactg gagtattaag agcctgggcc     2880

tgactgtcta cgccgactgc ctggctggca cgtacagtgg gggcaacaag cggaaactct     2940

ccacagccat cgcactcatt ggctgcccac cgctggtgct gctggatgag cccaccacag     3000

ggatggaccc ccaggcacgc cgcatgctgt ggaacgtcat cgtgagcatc atcagagaag     3060

ggagggctgt ggtcctcaca tcccacagca tggaagaatg tgaggcactg tgtacccggc     3120

tggccatcat ggtaaagggc gcctttcgat gtatgggcac cattcagcat ctcaagtcca     3180

aatttggaga tggctatatc gtcacaatga agatcaaatc cccgaaggac gacctgcttc     3240

ctgacctgaa ccctgtggag cagttcttcc aggggaactt cccaggcagt gtgcagaggg     3300

agaggcacta caacatgctc cagttccagg tctcctcctc ctccctggcg aggatcttcc     3360

agctcctcct ctcccacaag gacagcctgc tcatcgagga gtactcagtc acacagacca     3420

cactggacca ggtgtttgta aattttgcta aacagcagac tgaaagtcat gacctccctc     3480

tgcaccctcg agctgctgga gccagtcgac aagcccagga ctgaaagctt atcgataatc     3540

aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt     3600

ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg     3660

ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc     3720

ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt     3780

ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg     3840

ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg     3900

gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg ctgctcgcct     3960

gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc     4020

cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc     4080

ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcatgcc gctgatcagc     4140

ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     4200

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     4260

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     4320

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc     4380

ggaaagaacc agctggggat ttaaattagg gataacaggg taatggcgcg ggccgcagga     4440

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc     4500

ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc     4560

gcgcagagag ggagtggcca a                                               4581


<210>  5
<211>  199
<212>  DNA
<213>  Homo sapiens

<400>  5
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttagcctg      180

gtgctgtgtc agccccggg                                                   199


<210>  6
<211>  186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  untranslated region (UTR) sequence

<400>  6
gtgccgcagg gggacggctg ccttcggggg ggacggggca gggcggggtt cggcttctgg       60

cgtgtgaccg gcggctctag agcctctgct aaccatgttc atgccttctt ctttttccta      120

cagctcctgg gcaacgtgct ggttattgtg ctgtctcatc attttggcaa agaattacca      180

ccatgg                                                                 186


<210>  7
<211>  593
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  7
atcgataatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat       60

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct      120

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag      180

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc      240

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc      300

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct      360

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg      420

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg      480

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg      540

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc ccc             593


<210>  8
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bovine Growth Hormone poly-adenylation sequence

<400>  8
cgctgatcag cctcgactgt gccttctagt tgccagccat ctgttgtttg cccctccccc       60

gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata aaatgaggaa      120

attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt ggggcaggac      180

agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt gggctctatg      240

gcttctgagg cggaaagaac cagctgggg                                        269


<210>  9
<211>  4087
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example partial upstream vector sequence, comprising promoter, 
       CDS

<400>  9
ggtaccgggc cccagaagcc tggtggttgt ttgtccttct caggggaaaa gtgaggcggc       60

cccttggagg aaggggccgg gcagaatgat ctaatcggat tccaagcagc tcaggggatt      120

gtctttttct agcaccttct tgccactcct aagcgtcctc cgtgaccccg gctgggattt      180

agcctggtgc tgtgtcagcc ccgggtgccg cagggggacg gctgccttcg ggggggacgg      240

ggcagggcgg ggttcggctt ctggcgtgtg accggcggct ctagagcctc tgctaaccat      300

gttcatgcct tcttcttttt cctacagctc ctgggcaacg tgctggttat tgtgctgtct      360

catcattttg gcaaagaatt accaccatgg gcttcgtgag acagatacag cttttgctct      420

ggaagaactg gaccctgcgg aaaaggcaaa agattcgctt tgtggtggaa ctcgtgtggc      480

ctttatcttt atttctggtc ttgatctggt taaggaatgc caacccgctc tacagccatc      540

atgaatgcca tttccccaac aaggcgatgc cctcagcagg aatgctgccg tggctccagg      600

ggatcttctg caatgtgaac aatccctgtt ttcaaagccc caccccagga gaatctcctg      660

gaattgtgtc aaactataac aactccatct tggcaagggt atatcgagat tttcaagaac      720

tcctcatgaa tgcaccagag agccagcacc ttggccgtat ttggacagag ctacacatct      780

tgtcccaatt catggacacc ctccggactc acccggagag aattgcagga agaggaatac      840

gaataaggga tatcttgaaa gatgaagaaa cactgacact atttctcatt aaaaacatcg      900

gcctgtctga ctcagtggtc taccttctga tcaactctca agtccgtcca gagcagttcg      960

ctcatggagt cccggacctg gcgctgaagg acatcgcctg cagcgaggcc ctcctggagc     1020

gcttcatcat cttcagccag agacgcgggg caaagacggt gcgctatgcc ctgtgctccc     1080

tctcccaggg caccctacag tggatagaag acactctgta tgccaacgtg gacttcttca     1140

agctcttccg tgtgcttccc acactcctag acagccgttc tcaaggtatc aatctgagat     1200

cttggggagg aatattatct gatatgtcac caagaattca agagtttatc catcggccga     1260

gtatgcagga cttgctgtgg gtgaccaggc ccctcatgca gaatggtggt ccagagacct     1320

ttacaaagct gatgggcatc ctgtctgacc tcctgtgtgg ctaccccgag ggaggtggct     1380

ctcgggtgct ctccttcaac tggtatgaag acaataacta taaggccttt ctggggattg     1440

actccacaag gaaggatcct atctattctt atgacagaag aacaacatcc ttttgtaatg     1500

cattgatcca gagcctggag tcaaatcctt taaccaaaat cgcttggagg gcggcaaagc     1560

ctttgctgat gggaaaaatc ctgtacactc ctgattcacc tgcagcacga aggatactga     1620

agaatgccaa ctcaactttt gaagaactgg aacacgttag gaagttggtc aaagcctggg     1680

aagaagtagg gccccagatc tggtacttct ttgacaacag cacacagatg aacatgatca     1740

gagataccct ggggaaccca acagtaaaag actttttgaa taggcagctt ggtgaagaag     1800

gtattactgc tgaagccatc ctaaacttcc tctacaaggg ccctcgggaa agccaggctg     1860

acgacatggc caacttcgac tggagggaca tatttaacat cactgatcgc accctccgcc     1920

ttgtcaatca atacctggag tgcttggtcc tggataagtt tgaaagctac aatgatgaaa     1980

ctcagctcac ccaacgtgcc ctctctctac tggaggaaaa catgttctgg gccggagtgg     2040

tattccctga catgtatccc tggaccagct ctctaccacc ccacgtgaag tataagatcc     2100

gaatggacat agacgtggtg gagaaaacca ataagattaa agacaggtat tgggattctg     2160

gtcccagagc tgatcccgtg gaagatttcc ggtacatctg gggcgggttt gcctatctgc     2220

aggacatggt tgaacagggg atcacaagga gccaggtgca ggcggaggct ccagttggaa     2280

tctacctcca gcagatgccc tacccctgct tcgtggacga ttctttcatg atcatcctga     2340

accgctgttt ccctatcttc atggtgctgg catggatcta ctctgtctcc atgactgtga     2400

agagcatcgt cttggagaag gagttgcgac tgaaggagac cttgaaaaat cagggtgtct     2460

ccaatgcagt gatttggtgt acctggttcc tggacagctt ctccatcatg tcgatgagca     2520

tcttcctcct gacgatattc atcatgcatg gaagaatcct acattacagc gacccattca     2580

tcctcttcct gttcttgttg gctttctcca ctgccaccat catgctgtgc tttctgctca     2640

gcaccttctt ctccaaggcc agtctggcag cagcctgtag tggtgtcatc tatttcaccc     2700

tctacctgcc acacatcctg tgcttcgcct ggcaggaccg catgaccgct gagctgaaga     2760

aggctgtgag cttactgtct ccggtggcat ttggatttgg cactgagtac ctggttcgct     2820

ttgaagagca aggcctgggg ctgcagtgga gcaacatcgg gaacagtccc acggaagggg     2880

acgaattcag cttcctgctg tccatgcaga tgatgctcct tgatgctgct gtctatggct     2940

tactcgcttg gtaccttgat caggtgtttc caggagacta tggaacccca cttccttggt     3000

actttcttct acaagagtcg tattggcttg gcggtgaagg gtgttcaacc agagaagaaa     3060

gagccctgga aaagaccgag cccctaacag aggaaacgga ggatccagag cacccagaag     3120

gaatacacga ctccttcttt gaacgtgagc atccagggtg ggttcctggg gtatgcgtga     3180

agaatctggt aaagattttt gagccctgtg gccggccagc tgtggaccgt ctgaacatca     3240

ccttctacga gaaccagatc accgcattcc tgggccacaa tggagctggg aaaaccacca     3300

ccttgtccat cctgacgggt ctgttgccac caacctctgg gactgtgctc gttgggggaa     3360

gggacattga aaccagcctg gatgcagtcc ggcagagcct tggcatgtgt ccacagcaca     3420

acatcctgtt ccaccacctc acggtggctg agcacatgct gttctatgcc cagctgaaag     3480

gaaagtccca ggaggaggcc cagctggaga tggaagccat gttggaggac acaggcctcc     3540

accacaagcg gaatgaagag gctcaggacc tatcaggtgg catgcagaga aagctgtcgg     3600

ttgccattgc ctttgtggga gatgccaagg tggtgattct ggacgaaccc acctctgggg     3660

tggaccctta ctcgagacgc tcaatctggg atctgctcct gaagtatcgc tcaggcagaa     3720

ccatcatcat gtccactcac cacatggacg aggccgacct ccttggggac cgcattgcca     3780

tcattgccca gggaaggctc tactgctcag gcaccccact cttcctgaag aactgctttg     3840

gcacaggctt gtacttaacc ttggtgcgca agatgaaaaa catccagagc caaaggaaag     3900

gcagtgaggg gacctgcagc tgctcgtcta agggtttctc caccacgtgt ccagcccacg     3960

tcgatgacct aactccagaa caagtcctgg atggggatgt aaatgagctg atggatgtag     4020

ttctccacca tgttccagag gcaaagctgg tggagtgcat tggtcaagaa cttatcttcc     4080

ttcttcc                                                               4087


<210>  10
<211>  4203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  example partial downstream vector sequence, comprising CDS, 
       post-transcriptional response element, poly-adenylation sequence

<400>  10
acatccagag ccaaaggaaa ggcagtgagg ggacctgcag ctgctcgtct aagggtttct       60

ccaccacgtg tccagcccac gtcgatgacc taactccaga acaagtcctg gatggggatg      120

taaatgagct gatggatgta gttctccacc atgttccaga ggcaaagctg gtggagtgca      180

ttggtcaaga acttatcttc cttcttccaa ataagaactt caagcacaga gcatatgcca      240

gccttttcag agagctggag gagacgctgg ctgaccttgg tctcagcagt tttggaattt      300

ctgacactcc cctggaagag atttttctga aggtcacgga ggattctgat tcaggacctc      360

tgtttgcggg tggcgctcag cagaaaagag aaaacgtcaa cccccgacac ccctgcttgg      420

gtcccagaga gaaggctgga cagacacccc aggactccaa tgtctgctcc ccaggggcgc      480

cggctgctca cccagagggc cagcctcccc cagagccaga gtgcccaggc ccgcagctca      540

acacggggac acagctggtc ctccagcatg tgcaggcgct gctggtcaag agattccaac      600

acaccatccg cagccacaag gacttcctgg cgcagatcgt gctcccggct acctttgtgt      660

ttttggctct gatgctttct attgttatcc ctccttttgg cgaatacccc gctttgaccc      720

ttcacccctg gatatatggg cagcagtaca ccttcttcag catggatgaa ccaggcagtg      780

agcagttcac ggtacttgca gacgtcctcc tgaataagcc aggctttggc aaccgctgcc      840

tgaaggaagg gtggcttccg gagtacccct gtggcaactc aacaccctgg aagactcctt      900

ctgtgtcccc aaacatcacc cagctgttcc agaagcagaa atggacacag gtcaaccctt      960

caccatcctg caggtgcagc accagggaga agctcaccat gctgccagag tgccccgagg     1020

gtgccggggg cctcccgccc ccccagagaa cacagcgcag cacggaaatt ctacaagacc     1080

tgacggacag gaacatctcc gacttcttgg taaaaacgta tcctgctctt ataagaagca     1140

gcttaaagag caaattctgg gtcaatgaac agaggtatgg aggaatttcc attggaggaa     1200

agctcccagt cgtccccatc acgggggaag cacttgttgg gtttttaagc gaccttggcc     1260

ggatcatgaa tgtgagcggg ggccctatca ctagagaggc ctctaaagaa atacctgatt     1320

tccttaaaca tctagaaact gaagacaaca ttaaggtgtg gtttaataac aaaggctggc     1380

atgccctggt cagctttctc aatgtggccc acaacgccat cttacgggcc agcctgccta     1440

aggacaggag ccccgaggag tatggaatca ccgtcattag ccaacccctg aacctgacca     1500

aggagcagct ctcagagatt acagtgctga ccacttcagt ggatgctgtg gttgccatct     1560

gcgtgatttt ctccatgtcc ttcgtcccag ccagctttgt cctttatttg atccaggagc     1620

gggtgaacaa atccaagcac ctccagttta tcagtggagt gagccccacc acctactggg     1680

taaccaactt cctctgggac atcatgaatt attccgtgag tgctgggctg gtggtgggca     1740

tcttcatcgg gtttcagaag aaagcctaca cttctccaga aaaccttcct gcccttgtgg     1800

cactgctcct gctgtatgga tgggcggtca ttcccatgat gtacccagca tccttcctgt     1860

ttgatgtccc cagcacagcc tatgtggctt tatcttgtgc taatctgttc atcggcatca     1920

acagcagtgc tattaccttc atcttggaat tatttgagaa taaccggacg ctgctcaggt     1980

tcaacgccgt gctgaggaag ctgctcattg tcttccccca cttctgcctg ggccggggcc     2040

tcattgacct tgcactgagc caggctgtga cagatgtcta tgcccggttt ggtgaggagc     2100

actctgcaaa tccgttccac tgggacctga ttgggaagaa cctgtttgcc atggtggtgg     2160

aaggggtggt gtacttcctc ctgaccctgc tggtccagcg ccacttcttc ctctcccaat     2220

ggattgccga gcccactaag gagcccattg ttgatgaaga tgatgatgtg gctgaagaaa     2280

gacaaagaat tattactggt ggaaataaaa ctgacatctt aaggctacat gaactaacca     2340

agatttatcc aggcacctcc agcccagcag tggacaggct gtgtgtcgga gttcgccctg     2400

gagagtgctt tggcctcctg ggagtgaatg gtgccggcaa aacaaccaca ttcaagatgc     2460

tcactgggga caccacagtg acctcagggg atgccaccgt agcaggcaag agtattttaa     2520

ccaatatttc tgaagtccat caaaatatgg gctactgtcc tcagtttgat gcaatcgatg     2580

agctgctcac aggacgagaa catctttacc tttatgcccg gcttcgaggt gtaccagcag     2640

aagaaatcga aaaggttgca aactggagta ttaagagcct gggcctgact gtctacgccg     2700

actgcctggc tggcacgtac agtgggggca acaagcggaa actctccaca gccatcgcac     2760

tcattggctg cccaccgctg gtgctgctgg atgagcccac cacagggatg gacccccagg     2820

cacgccgcat gctgtggaac gtcatcgtga gcatcatcag agaagggagg gctgtggtcc     2880

tcacatccca cagcatggaa gaatgtgagg cactgtgtac ccggctggcc atcatggtaa     2940

agggcgcctt tcgatgtatg ggcaccattc agcatctcaa gtccaaattt ggagatggct     3000

atatcgtcac aatgaagatc aaatccccga aggacgacct gcttcctgac ctgaaccctg     3060

tggagcagtt cttccagggg aacttcccag gcagtgtgca gagggagagg cactacaaca     3120

tgctccagtt ccaggtctcc tcctcctccc tggcgaggat cttccagctc ctcctctccc     3180

acaaggacag cctgctcatc gaggagtact cagtcacaca gaccacactg gaccaggtgt     3240

ttgtaaattt tgctaaacag cagactgaaa gtcatgacct ccctctgcac cctcgagctg     3300

ctggagccag tcgacaagcc caggactgaa agcttatcga taatcaacct ctggattaca     3360

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     3420

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     3480

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     3540

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     3600

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     3660

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     3720

tggtgttgtc ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga     3780

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     3840

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     3900

gtcggatctc cctttgggcc gcctccccgc atgccgctga tcagcctcga ctgtgccttc     3960

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc     4020

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg     4080

tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa     4140

tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa gaaccagctg     4200

ggg                                                                   4203


<210>  11
<211>  208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  overlap C sequence with out-of-frame AUG codons prior to an 
       in-frame AUG codon

<400>  11
acauccagag ccaaaggaaa ggcagugagg ggaccugcag cugcucgucu aaggguuucu       60

ccaccacgug uccagcccac gucgaugacc uaacuccaga acaaguccug gauggggaug      120

uaaaugagcu gauggaugua guucuccacc auguuccaga ggcaaagcug guggagugca      180

uuggucaaga acuuaucuuc cuucuucc                                         208


