                         SEQUENCE LISTING

<110>  F. Hoffmann la Roche
 
<120>  PAPD5 and PAPD7 inhibitors for treating a hepatitis B infection

<130>  P33547-WO

<150>  EP16175045.0
<151>  2016-06-17

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Arg Pro Arg Ser Ala Pro Gly Lys Pro Arg Arg Arg Ser 
1               5                   10                  15      


Arg Ala Arg Leu Arg Ser Ser Arg Thr Pro Ser Gly Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Ser Ser Ser Ser Ser Thr Ala Thr Gly Gly Ser Gly 
        35                  40                  45              


Ser Ser Thr Gly Ser Pro Gly Gly Ala Ala Ser Ala Pro Ala Pro Ala 
    50                  55                  60                  


Pro Ala Gly Met Tyr Arg Ser Gly Glu Arg Leu Leu Gly Ser His Ala 
65                  70                  75                  80  


Leu Pro Ala Glu Gln Arg Asp Phe Leu Pro Leu Glu Thr Thr Asn Asn 
                85                  90                  95      


Asn Asn Asn His His Gln Pro Gly Ala Trp Ala Arg Arg Ala Gly Ser 
            100                 105                 110         


Ser Ala Ser Ser Pro Pro Ser Ala Ser Ser Ser Pro His Pro Ser Ala 
        115                 120                 125             


Ala Val Pro Ala Ala Asp Pro Ala Asp Ser Ala Ser Gly Ser Ser Asn 
    130                 135                 140                 


Lys Arg Lys Arg Asp Asn Lys Ala Ser Thr Tyr Gly Leu Asn Tyr Ser 
145                 150                 155                 160 


Leu Leu Gln Pro Ser Gly Gly Arg Ala Ala Gly Gly Gly Arg Ala Asp 
                165                 170                 175     


Gly Gly Gly Val Val Tyr Ser Gly Thr Pro Trp Lys Arg Arg Asn Tyr 
            180                 185                 190         


Asn Gln Gly Val Val Gly Leu His Glu Glu Ile Ser Asp Phe Tyr Glu 
        195                 200                 205             


Tyr Met Ser Pro Arg Pro Glu Glu Glu Lys Met Arg Met Glu Val Val 
    210                 215                 220                 


Asn Arg Ile Glu Ser Val Ile Lys Glu Leu Trp Pro Ser Ala Asp Val 
225                 230                 235                 240 


Gln Ile Phe Gly Ser Phe Lys Thr Gly Leu Tyr Leu Pro Thr Ser Asp 
                245                 250                 255     


Ile Asp Leu Val Val Phe Gly Lys Trp Glu Asn Leu Pro Leu Trp Thr 
            260                 265                 270         


Leu Glu Glu Ala Leu Arg Lys His Lys Val Ala Asp Glu Asp Ser Val 
        275                 280                 285             


Lys Val Leu Asp Lys Ala Thr Val Pro Ile Ile Lys Leu Thr Asp Ser 
    290                 295                 300                 


Phe Thr Glu Val Lys Val Asp Ile Ser Phe Asn Val Gln Asn Gly Val 
305                 310                 315                 320 


Arg Ala Ala Asp Leu Ile Lys Asp Phe Thr Lys Lys Tyr Pro Val Leu 
                325                 330                 335     


Pro Tyr Leu Val Leu Val Leu Lys Gln Phe Leu Leu Gln Arg Asp Leu 
            340                 345                 350         


Asn Glu Val Phe Thr Gly Gly Ile Gly Ser Tyr Ser Leu Phe Leu Met 
        355                 360                 365             


Ala Val Ser Phe Leu Gln Leu His Pro Arg Glu Asp Ala Cys Ile Pro 
    370                 375                 380                 


Asn Thr Asn Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu Leu Tyr Gly 
385                 390                 395                 400 


Arg His Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Asp Gly Gly 
                405                 410                 415     


Ser Tyr Val Ala Lys Asp Glu Val Gln Lys Asn Met Leu Asp Gly Tyr 
            420                 425                 430         


Arg Pro Ser Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro Gly Asn Asp 
        435                 440                 445             


Val Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Ala Phe Asp 
    450                 455                 460                 


Tyr Ala Tyr Val Val Leu Ser His Ala Val Ser Pro Ile Ala Lys Tyr 
465                 470                 475                 480 


Tyr Pro Asn Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile Ile Arg Val 
                485                 490                 495     


Thr Asp Glu Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys Gln Trp Gly 
            500                 505                 510         


Leu Lys Asn Arg Pro Glu Pro Ser Cys Asn Gly Asn Gly Val Thr Leu 
        515                 520                 525             


Ile Val Asp Thr Gln Gln Leu Asp Lys Cys Asn Asn Asn Leu Ser Glu 
    530                 535                 540                 


Glu Asn Glu Ala Leu Gly Lys Cys Arg Ser Lys Thr Ser Glu Ser Leu 
545                 550                 555                 560 


Ser Lys His Ser Ser Asn Ser Ser Ser Gly Pro Val Ser Ser Ser Ser 
                565                 570                 575     


Ala Thr Gln Ser Ser Ser Ser Asp Val Asp Ser Asp Ala Thr Pro Cys 
            580                 585                 590         


Lys Thr Pro Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly Asn Arg Val 
        595                 600                 605             


Gly Ser Gln Asp Val Ser Leu Glu Ser Ser Gln Ala Val Gly Lys Met 
    610                 615                 620                 


Gln Ser Thr Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn Lys Ser Gln 
625                 630                 635                 640 


His Gly Ser Ala Arg Leu Phe Arg Ser Ser Ser Lys Gly Phe Gln Gly 
                645                 650                 655     


Thr Thr Gln Thr Ser His Gly Ser Leu Met Thr Asn Lys Gln His Gln 
            660                 665                 670         


Gly Lys Ser Asn Asn Gln Tyr Tyr His Gly Lys Lys Arg Lys His Lys 
        675                 680                 685             


Arg Asp Ala Pro Leu Ser Asp Leu Cys Arg 
    690                 695             


<210>  2
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Arg Pro Arg Ser Ala Pro Gly Lys Pro Arg Arg Arg Ser 
1               5                   10                  15      


Arg Ala Arg Leu Arg Ser Ser Arg Thr Pro Ser Gly Gly Ala Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Ser Ser Ser Ser Ser Thr Ala Thr Gly Gly Ser Gly 
        35                  40                  45              


Ser Ser Thr Gly Ser Pro Gly Gly Ala Ala Ser Ala Pro Ala Pro Ala 
    50                  55                  60                  


Pro Ala Gly Met Tyr Arg Ser Gly Glu Arg Leu Leu Gly Ser His Ala 
65                  70                  75                  80  


Leu Pro Ala Glu Gln Arg Asp Phe Leu Pro Leu Glu Thr Thr Asn Asn 
                85                  90                  95      


Asn Asn Asn His His Gln Pro Gly Ala Trp Ala Arg Arg Ala Gly Ser 
            100                 105                 110         


Ser Ala Ser Ser Pro Pro Ser Ala Ser Ser Ser Pro His Pro Ser Ala 
        115                 120                 125             


Ala Val Pro Ala Ala Asp Pro Ala Asp Ser Ala Ser Gly Ser Ser Asn 
    130                 135                 140                 


Lys Arg Lys Arg Asp Asn Lys Ala Ser Thr Tyr Gly Leu Asn Tyr Ser 
145                 150                 155                 160 


Leu Leu Gln Pro Ser Gly Gly Arg Ala Ala Gly Gly Gly Arg Ala Asp 
                165                 170                 175     


Gly Gly Gly Val Val Tyr Ser Gly Thr Pro Trp Lys Arg Arg Asn Tyr 
            180                 185                 190         


Asn Gln Gly Val Val Gly Leu His Glu Glu Ile Ser Asp Phe Tyr Glu 
        195                 200                 205             


Tyr Met Ser Pro Arg Pro Glu Glu Glu Lys Met Arg Met Glu Val Val 
    210                 215                 220                 


Asn Arg Ile Glu Ser Val Ile Lys Glu Leu Trp Pro Ser Ala Asp Val 
225                 230                 235                 240 


Gln Ile Phe Gly Ser Phe Lys Thr Gly Leu Tyr Leu Pro Thr Ser Asp 
                245                 250                 255     


Ile Asp Leu Val Val Phe Gly Lys Trp Glu Asn Leu Pro Leu Trp Thr 
            260                 265                 270         


Leu Glu Glu Ala Leu Arg Lys His Lys Val Ala Asp Glu Asp Ser Val 
        275                 280                 285             


Lys Val Leu Asp Lys Ala Thr Val Pro Ile Ile Lys Leu Thr Asp Ser 
    290                 295                 300                 


Phe Thr Glu Val Lys Val Asp Ile Ser Phe Asn Val Gln Asn Gly Val 
305                 310                 315                 320 


Arg Ala Ala Asp Leu Ile Lys Asp Phe Thr Lys Lys Tyr Pro Val Leu 
                325                 330                 335     


Pro Tyr Leu Val Leu Val Leu Lys Gln Phe Leu Leu Gln Arg Asp Leu 
            340                 345                 350         


Asn Glu Val Phe Thr Gly Gly Ile Gly Ser Tyr Ser Leu Phe Leu Met 
        355                 360                 365             


Ala Val Ser Phe Leu Gln Leu His Pro Arg Glu Asp Ala Cys Ile Pro 
    370                 375                 380                 


Asn Thr Asn Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu Leu Tyr Gly 
385                 390                 395                 400 


Arg His Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Asp Gly Gly 
                405                 410                 415     


Ser Tyr Val Ala Lys Asp Glu Val Gln Lys Asn Met Leu Asp Gly Tyr 
            420                 425                 430         


Arg Pro Ser Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro Gly Asn Asp 
        435                 440                 445             


Val Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Ala Phe Asp 
    450                 455                 460                 


Tyr Ala Tyr Val Val Leu Ser His Ala Val Ser Pro Ile Ala Lys Tyr 
465                 470                 475                 480 


Tyr Pro Asn Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile Ile Arg Val 
                485                 490                 495     


Thr Asp Glu Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys Gln Trp Gly 
            500                 505                 510         


Leu Lys Asn Arg Pro Glu Pro Ser Cys Asn Gly Asn Gly Val Thr Leu 
        515                 520                 525             


Ile Val Asp Thr Gln Gln Leu Asp Lys Cys Asn Asn Asn Leu Ser Glu 
    530                 535                 540                 


Glu Asn Glu Ala Leu Gly Lys Cys Arg Ser Lys Thr Ser Glu Ser Leu 
545                 550                 555                 560 


Ser Lys His Ser Ser Asn Ser Ser Ser Gly Pro Val Ser Ser Ser Ser 
                565                 570                 575     


Ala Thr Gln Ser Ser Ser Ser Asp Val Asp Ser Asp Ala Thr Pro Cys 
            580                 585                 590         


Lys Thr Pro Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly Asn Arg Val 
        595                 600                 605             


Gly Ser Gln Asp Val Ser Leu Glu Ser Ser Gln Ala Val Gly Lys Met 
    610                 615                 620                 


Gln Ser Thr Gln Thr Thr Asn Thr Ser Asn Ser Thr Asn Lys Ser Gln 
625                 630                 635                 640 


His Gly Ser Ala Arg Leu Phe Arg Ser Ser Ser Lys Gly Phe Gln Gly 
                645                 650                 655     


Thr Thr Gln Thr Ser His Gly Ser Leu Met Thr Asn Lys Gln His Gln 
            660                 665                 670         


Gly Lys Ser Asn Asn Gln Tyr Tyr His Gly Lys Lys Arg Lys His Lys 
        675                 680                 685             


Arg Asp Ala Pro Leu Ser Asp Leu Cys Arg 
    690                 695             


<210>  3
<211>  792
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Pro Arg Val Ala Trp Ile Gln Pro Glu Gln Lys Gly Pro Ala 
1               5                   10                  15      


Asn Ala Leu Trp Met Gln Ile Trp Glu Thr Ser Gln Gly Val Gly Arg 
            20                  25                  30          


Gly Gly Ser Gly Phe Ala Ser Tyr Phe Cys Leu Asn Ser Pro Ala Leu 
        35                  40                  45              


Asp Thr Ala Ala Ala Ala Gly Ala Ala Gly Arg Gly Ser Gly Gly Leu 
    50                  55                  60                  


Gly Pro Ala Leu Pro Ala Ala Ser Pro Pro Pro Pro Gly Pro Thr Ala 
65                  70                  75                  80  


Pro Ala Ala Leu Pro Pro Ala Leu Leu Thr Ala Leu Gly Pro Ala Ala 
                85                  90                  95      


Glu Gly Ala Arg Arg Leu His Lys Ser Pro Ser Leu Ser Ser Ser Ser 
            100                 105                 110         


Ser Ser Ser Ser Ser Asn Ala Glu Ser Gly Thr Glu Ser Pro Gly Cys 
        115                 120                 125             


Ser Ser Ser Ser Ser Ser Ser Ala Ser Leu Gly Arg Pro Gly Gly Gly 
    130                 135                 140                 


Arg Gly Gly Ala Phe Phe Asn Phe Ala Asp Gly Ala Pro Ser Ala Pro 
145                 150                 155                 160 


Gly Thr Ala Asn Gly His Pro Gly Pro Arg Gly Pro Ala Pro Ala Gly 
                165                 170                 175     


Ser Pro Ser Gln His Gln Phe His Pro Gly Arg Arg Lys Arg Glu Asn 
            180                 185                 190         


Lys Ala Ser Thr Tyr Gly Leu Asn Tyr Leu Leu Ser Gly Ser Arg Ala 
        195                 200                 205             


Ala Ala Leu Ser Gly Gly Gly Gly Pro Gly Ala Gln Ala Pro Arg Pro 
    210                 215                 220                 


Gly Thr Pro Trp Lys Ser Arg Ala Tyr Ser Pro Gly Ile Gln Gly Leu 
225                 230                 235                 240 


His Glu Glu Ile Ile Asp Phe Tyr Asn Phe Met Ser Pro Cys Pro Glu 
                245                 250                 255     


Glu Ala Ala Met Arg Arg Glu Val Val Lys Arg Ile Glu Thr Val Val 
            260                 265                 270         


Lys Asp Leu Trp Pro Thr Ala Asp Val Gln Ile Phe Gly Ser Phe Ser 
        275                 280                 285             


Thr Gly Leu Tyr Leu Pro Thr Ser Asp Ile Asp Leu Val Val Phe Gly 
    290                 295                 300                 


Lys Trp Glu Arg Pro Pro Leu Gln Leu Leu Glu Gln Ala Leu Arg Lys 
305                 310                 315                 320 


His Asn Val Ala Glu Pro Cys Ser Ile Lys Val Leu Asp Lys Ala Thr 
                325                 330                 335     


Val Pro Ile Ile Lys Leu Thr Asp Gln Glu Thr Glu Val Lys Val Asp 
            340                 345                 350         


Ile Ser Phe Asn Met Glu Thr Gly Val Arg Ala Ala Glu Phe Ile Lys 
        355                 360                 365             


Asn Tyr Met Lys Lys Tyr Ser Leu Leu Pro Tyr Leu Ile Leu Val Leu 
    370                 375                 380                 


Lys Gln Phe Leu Leu Gln Arg Asp Leu Asn Glu Val Phe Thr Gly Gly 
385                 390                 395                 400 


Ile Ser Ser Tyr Ser Leu Ile Leu Met Ala Ile Ser Phe Leu Gln Leu 
                405                 410                 415     


His Pro Arg Ile Asp Ala Arg Arg Ala Asp Glu Asn Leu Gly Met Leu 
            420                 425                 430         


Leu Val Glu Phe Phe Glu Leu Tyr Gly Arg Asn Phe Asn Tyr Leu Lys 
        435                 440                 445             


Thr Gly Ile Arg Ile Lys Glu Gly Gly Ala Tyr Ile Ala Lys Glu Glu 
    450                 455                 460                 


Ile Met Lys Ala Met Thr Ser Gly Tyr Arg Pro Ser Met Leu Cys Ile 
465                 470                 475                 480 


Glu Asp Pro Leu Leu Pro Gly Asn Asp Val Gly Arg Ser Ser Tyr Gly 
                485                 490                 495     


Ala Met Gln Val Lys Gln Val Phe Asp Tyr Ala Tyr Ile Val Leu Ser 
            500                 505                 510         


His Ala Val Ser Pro Leu Ala Arg Ser Tyr Pro Asn Arg Asp Ala Glu 
        515                 520                 525             


Ser Thr Leu Gly Arg Ile Ile Lys Val Thr Gln Glu Val Ile Asp Tyr 
    530                 535                 540                 


Arg Arg Trp Ile Lys Glu Lys Trp Gly Ser Lys Ala His Pro Ser Pro 
545                 550                 555                 560 


Gly Met Asp Ser Arg Ile Lys Ile Lys Glu Arg Ile Ala Thr Cys Asn 
                565                 570                 575     


Gly Glu Gln Thr Gln Asn Arg Glu Pro Glu Ser Pro Tyr Gly Gln Arg 
            580                 585                 590         


Leu Thr Leu Ser Leu Ser Ser Pro Gln Leu Leu Ser Ser Gly Ser Ser 
        595                 600                 605             


Ala Ser Ser Val Ser Ser Leu Ser Gly Ser Asp Val Asp Ser Asp Thr 
    610                 615                 620                 


Pro Pro Cys Thr Thr Pro Ser Val Tyr Gln Phe Ser Leu Gln Ala Pro 
625                 630                 635                 640 


Ala Pro Leu Met Ala Gly Leu Pro Thr Ala Leu Pro Met Pro Ser Gly 
                645                 650                 655     


Lys Pro Gln Pro Thr Thr Ser Arg Thr Leu Ile Met Thr Thr Asn Asn 
            660                 665                 670         


Gln Thr Arg Phe Thr Ile Pro Pro Pro Thr Leu Gly Val Ala Pro Val 
        675                 680                 685             


Pro Cys Arg Gln Ala Gly Val Glu Gly Thr Ala Ser Leu Lys Ala Val 
    690                 695                 700                 


His His Met Ser Ser Pro Ala Ile Pro Ser Ala Ser Pro Asn Pro Leu 
705                 710                 715                 720 


Ser Ser Pro His Leu Tyr His Lys Gln His Asn Gly Met Lys Leu Ser 
                725                 730                 735     


Met Lys Gly Ser His Gly His Thr Gln Gly Gly Gly Tyr Ser Ser Val 
            740                 745                 750         


Gly Ser Gly Gly Val Arg Pro Pro Val Gly Asn Arg Gly His His Gln 
        755                 760                 765             


Tyr Asn Arg Thr Gly Trp Arg Arg Lys Lys His Thr His Thr Arg Asp 
    770                 775                 780                 


Ser Leu Pro Val Ser Leu Ser Arg 
785                 790         


<210>  4
<211>  8114
<212>  DNA
<213>  Homo sapiens

<400>  4
acaacgcgct ccctgcgggg cgggcggcaa cctccatgcg gcctcgtcca cgctcagcac       60

cggggaagcc gaggcggaga agccgcgcgc gcctcagaag ctcccggacg cccagcggcg      120

gcgcgagcgg cggcggcggc agcagcagca gcagcagcac ggccaccggc gggagcggca      180

gcagcaccgg cagccccggc ggcgcggcct cggccccggc cccggccccg gccggcatgt      240

atcgctccgg ggagcgcctg ctgggcagcc acgcgctgcc cgcggagcag cgggacttcc      300

tgcccctaga gacgaccaac aacaacaaca accaccacca gcccggggcc tgggcccgcc      360

gggcgggctc ctcggcgtcc tcgcctccct cggcgtcctc gtccccgcac ccttcggccg      420

ccgtccccgc cgccgatcca gccgattcgg cctcgggcag cagcaacaag aggaagcgcg      480

acaacaaggc cagcacgtat ggactcaact acagcctgct gcagcccagc ggagggcggg      540

ccgcgggggg cggccgagca gacggcggcg gggtcgtgta cagcgggacc ccgtggaaac      600

ggaggaacta caaccaggga gtcgtgggtc tgcatgaaga aatcagtgat ttttatgaat      660

acatgtctcc aagacctgag gaggagaaga tgcggatgga ggtggtgaac aggatcgaga      720

gtgtaattaa ggagctctgg cccagcgctg acgtccagat atttggaagt tttaaaactg      780

gactttattt acctactagt gacatcgacc tagtggtgtt tgggaagtgg gagaacctac      840

ccctctggac tctggaagaa gctcttcgga aacacaaagt cgcagatgag gattcggtga      900

aagttttaga caaagcaact gtacctatta ttaaattaac agattctttt actgaagtga      960

aagttgatat cagctttaat gtacagaatg gcgtgagagc agctgacctc atcaaagatt     1020

ttaccaagaa atatcctgta ttgccatact tggttttagt attgaaacaa ttcctattgc     1080

agagggacct taatgaagta tttacaggtg gaattggttc ttatagtctc tttttaatgg     1140

cagtcagttt ccttcagtta catcccaggg aagatgcttg catccccaat acaaactatg     1200

gtgttctctt aatagaattt tttgaattat atggacgaca cttcaattat ttaaagactg     1260

gcatccggat aaaggatggt ggttcatatg tggccaaaga tgaagtacag aaaaatatgc     1320

tagatggcta caggccatca atgctttata tcgaagatcc tttacaacca ggtaacgatg     1380

ttggaaggag ttcatatggg gccatgcaag tgaagcaggc ctttgattat gcctacgttg     1440

ttttgagtca tgctgtatca ccaatagcaa agtactatcc caacaatgaa acagaaagca     1500

tactaggtag aataattaga gtaacagatg aagttgccac atatagagat tggatatcaa     1560

agcagtgggg cttgaagaat agacctgagc cttcatgcaa tggaaatggt gttaccttga     1620

tagtagatac tcagcagtta gataaatgta ataataatct atctgaagaa aatgaagccc     1680

ttggaaaatg tagaagtaaa acctcggaat ctcttagtaa acactcttca aactcttcat     1740

caggtccagt gtcgtcctct tctgccacac agtccagctc tagtgatgta gattccgatg     1800

caacaccatg caaaaccccg aaacagctgc tttgccgtcc gtccactggg aaccgagtag     1860

ggtcgcaaga tgtatccttg gagtcctctc aggcagttgg gaaaatgcaa agcacccaaa     1920

ccactaacac atccaacagc accaacaaat ctcagcatgg atcagcaagg ctctttcgtt     1980

cttccagcaa aggcttccaa ggtacaactc aaacaagcca tggttccttg atgacaaaca     2040

aacaacatca aggcaaatcc aataatcagt attaccatgg caaaaagagg aaacacaaga     2100

gggacgcgcc cctctcagac ctctgtagat agtcagcgct gcgcggtgga ctgtcttctc     2160

tgtgcaatga tctcatgctc aggacagttg cgcagggact cctgggagat attcaggagc     2220

ctcacactgt tcagacgttg acttagcaac tgcgtttttt cccagctcgc cacagaatgg     2280

atcatgaaga ctgacaactg caaaaaaaac aaaacaaaac aaaaaaaaaa gcaagcaaaa     2340

aagagggaaa aaaaaggctg cttatttgat aagtcatatg ctacaacagg gtcattttaa     2400

gatttaaagc ttgaatgtaa aataaatata tttctcattg gctttatgca gagttatagg     2460

gaatagtatt cagtgttggt agggtgatag aaacaaaaaa cagtatcaga ggatgaggtg     2520

gggaaggaaa acaaaggtat ctgataggaa gtccagattc caaaggggaa agtgatctgt     2580

gcatgttttt tttttaaata tttttgcata tatttaccat tttattgtgt gtatatatag     2640

aagaccatat aggagattga tatttgtaat agtggatttg ttaataatac tttttacata     2700

acattactgt ttaaattgta aacagatttt ttctcaggat tagtttgaaa aataatctaa     2760

attgtcatct taacatccat atatagggaa gtgattagtt ctattactca atttgttttt     2820

ctcagcattg aaatgactta atagaaccct tgtgtcctgc tgcaaaaatt tttcctctct     2880

aaagaaaagg tttatggtgg caaatgatgt ttattttatt ttgtaaaaaa aaaaaaatgt     2940

actatgtact tttgtgtaaa cactgaaaaa tctctggtca tctccgagaa ttaacttgca     3000

actgttttct atagtgctgt cgtcttgggc aatgggcaat tacatgactt tgtgtttgct     3060

tcctttgcag tctttttttt ttccccccat ttcttcctaa taggaaaaaa aaaaaaaaaa     3120

aggtcaccca tgtctggtct cattcctgtt gcagtgaaac ttcgagttcc acagactttg     3180

catgctggct tctctaaccc tgtgtgctgc gtgtgcctgt ttctcatctc ttattctttt     3240

taaaattcat gcttaactac tgtgggagaa taactgtaaa cagctttaat taaatcatac     3300

ttataaaaaa ctattttctt atattccact ctatgctttt ggtattgttg atctttacaa     3360

attaaatggt ctttgataat ggatctattt tgtattgcct tattaagacc aaatacttct     3420

tgtcatccca ttctttatcc tcttctttca tggaattgtt atcgttaatt aaaacttttt     3480

taaacattgg cttgtttcaa tcatactgta aattttggtt gtagtcagct ttgagtgcaa     3540

tgagatgtat aattctgtta tcattacctg ttgagtttga aactcagttg ggaatattta     3600

atataataga atgtaagtga catttctgaa aatgctttct ttcagggtga aagctcttat     3660

gtttagcatc aatgtgtatg gctctgttaa atgcagccat ttctgagacg agattctttt     3720

atatatatat acatataaag tactattggc ttttaggagt ttcttttata tacatttatg     3780

aaatactgaa gaccaatcag accattaatg gacacttagt gtaacttttt ataaagaaaa     3840

taatgctaaa gtaagaccaa aactgatgtc atcactgaaa ttaacaattt tcaatatgtt     3900

catattttaa ttcacaatgg aaaaatgtgt tccaaaactg gaaactcata gtactcgtgt     3960

aaactgtgga agatttcaaa tgtgatgtta ttttgacaat gttttaaatt ttagagtcac     4020

attttattct gatcagaatt tttattgaga tgttgagctt ttgtttttga aactagtttg     4080

tcataacatt gtgcataatc acagtattta ttttctagga caattgtgaa tgtgtagact     4140

tatgtttact gctaagggaa caattattta taaaataata ttaaatccag tattagctgc     4200

ctatttcaga cacttaatac ttgcagagat ctatgttaca tttaccacac tgaagttttt     4260

tttgttgttt tttgtttgtt tttaaagaat caccctcatt gttgaaagta aatgtactct     4320

tagggtgcga atattagtgt tccaataagc atgtgattat attaaggtgg tggtagcggg     4380

aagataattc tgattccatt gggaatctta ggttttcgta aatttattgg gaaaatagtt     4440

tttcctgtac tgctgaagtt tctttttggt aaacagtatc tttctaaaag aaaaaagcat     4500

gaaggagaaa ttgaggtgtg tatacatttc ctcaaatgac cagcattgta ttcgtgaata     4560

ctgtgtatct tgcagtgaac agtgtggaag ctgttcattt ttcaatctga agtaaaatac     4620

tttcaagaac ttttagtttg cctgctcatt tgttttatac atttcatcta tttgactcct     4680

atcttatttc ttttttgagt tttaatactt cctatatttt gtgaatatat cagaaatgtg     4740

tcatttatat attagagtcc attcatatcc atgaatcata accttccttt gctaatactt     4800

gttgaatggg attttacaaa ttctccctca ctctggtgac atttctcagg cagtcatgta     4860

tgtgtacctg gccattagaa atattaatat ttaaagactg ttttttagag gagctgatgg     4920

gttggtgagg tgtcagcaca aaatcttact ggttatgttt tgatgataaa agtatatcca     4980

ttttttccct ccagctttaa ggtgactgtg aaggtgcctg gttttgaatg tctttgtttg     5040

gtttggagat gtcgcactca gttttcaaat ctagcttgga tctgtaggac ctatgttttt     5100

tacaagtaat tgccctccag tcttcaacag ttgattctgt tttattttta tcctgttttg     5160

agtgtacttt acctttactt gcattttgag cctcattaat atttaggtta tttgatttgg     5220

ctccagatat tcctagatct gcacagggca aaacatgggc tatagggtga gcatttttaa     5280

ttgtcttttt ctgctggaac cttatatctc tccatgtgtt ttctgctcct tccctccccc     5340

atgaaatggt aagtgtgact tgtgtttgcc tgaacctgtg gactagtgtt tggggtttct     5400

ggaaacacta gagggtcaga aaagagtaat gaccaccgtg acgtgcagga ttctcttgct     5460

gtgacatgtt cattgcaaag ccctctccag tgactaggag gtgtagttat taaggttgat     5520

ctgttagaaa tcaccattat taggtattag tggtagatgt tgctgatact tttattggtc     5580

atgactacat ctcagtttta ctttaatatt gatctatagt ttgatcagtt ccttgaattc     5640

taatatgttg atttctcagt gtttctgtca ctaaccaaga atgtttctag gcagttggtt     5700

gcttcacagt caaaactaaa tggtaaacta tcaaaaatac attcccaatt ttgctgtgat     5760

aaatattgaa atgttaaaat taatgaacag aagaatttat tcttacccat ctattcttgt     5820

tctcctagtt cattaaactt tcagttattg gaaaggcaca ttctcaaagt attttatgag     5880

caaaatattc tataaatgcg tctaacaaac ctaattgaat ataaaagtta tatttagtag     5940

ttactgttga tagtaatttt catcagggtc atagttcatc tagtaaaata tttagagaat     6000

gatgttaaca ttccagcatt aaagtgggaa caaagattta tatatgaaat tccttaaaag     6060

agttcatctt gccttggttt ctgaccctca agactctagc tacctgccat cttgtcaaaa     6120

catttgtggg tagaataagt gttaaagatc aaattttaat atgcttctcg atatttaaca     6180

tagctaagaa gccagatttt actgtagaag ttatttacat gatttgaaaa cttgacctaa     6240

ctggaagcct ttttctcagt catcttgttc taagccatct tgacttcaca cccttagcga     6300

cttttctttt ttttttggtc aaagataatg agctaaatat atatagacgt tgaatgttga     6360

caaaattatt aaccagaaaa attgcttata aaggctgctg atctatttga tacctagaat     6420

taaatatttg aggacagttt ttagttaata aactgctaat gtttatttta ctgtctctca     6480

ggtttttggt ttttttaaaa aaaatgtgtt tggcctttac attttctact taagtgtgta     6540

ctttattgag tttaaccttg tctgtagcct agtagcctga aagaaaagga gacagaacca     6600

gagagatgga tgtagtgcat tccctttggt tattacacat ttgtggtagc tcctggattt     6660

actgagagat attttagcta tgtcaataag aacagctaat gatgtggaaa tcaggtgttc     6720

tcttgtgtat ttcagtgaac atttttatta gtagttgcat atcatctcta gttccacatt     6780

ttaacttaac gtctttgtgg cttcaccact gagctacctt tcactacacc agcttctgtg     6840

tggcctggta acatggaagg tctctcctaa ggacagtctg gacgtatttt gggggaatgt     6900

tatttatctt aaagatgcct agaaacaaaa cgcatatagt accagtgaga aactatgaag     6960

taaacaagtt gctcaggccg ggcatggtgg ctcacgcctg taatcccagc actttgggag     7020

gccgaagcgg gaggatggct tgaggctggg agtttgagac cttcatctct taaaaaaaca     7080

aacaaaaacc tgaatggtga ggtgtggtgg aattgggtag gggagggaaa ggaggacttg     7140

gaaaagcatt ctccaaagcc agcaacttgg tgaagttcag tacttgcctc ttagaggtta     7200

ggccatgcct ttcaaagaga gtgaaatgat gggttatcag ccacattctt ggagttaata     7260

tttttcttca tctttcagtt tgggttctgt gctattcata gttcttccct aagaccattt     7320

cattattacc ttttatattt agttgcaatt tattataata tgttgttttg tccctgaact     7380

taatctccta attttaagat cctctctgat ttttgcatat tgaaacttac agaagtcact     7440

ttaaaaaagt cttttgaaag tcctacaatc ctaaaataaa tcacaagctt gtttgttaga     7500

cgtgtcaaga gtctccagtc tttactacta aaaagcagca ctgccttaac acacattgtt     7560

atgggtgaaa agtgagggac gaccagtgta gtttctggat ataaagtgtg aaggactgtt     7620

gagttaaaca tttttagtgg aatatacata gataacgtgt atttagaaac tttggtgaag     7680

ccagtatttg tttttagtaa cctttttatg tatttccttc tttgattagc attgtcttca     7740

gtgttaagaa atgtggactc ctgtgaggtg ctggaggttt gaatcatctt gaaaactttc     7800

caatcttgtc tagttaccac tgcagagaca ctaaggaatt taccagaaaa agatatttga     7860

tacaagtgat ttaagaaatc tcaacatttc ctgaggccgt atcactgggc aaccagtgat     7920

gaaaactatg aatgaattgc acacctggaa gattttttaa gctaatgaca gtttcttcaa     7980

agatgtcaat tatttgcctt ggaaatttta taaattgcat ttctatgcac atcggcctct     8040

agtgcttacc actcggttta ttattcataa tctgcaattc aataaaggct ttgtgttttc     8100

atttatcttc aaaa                                                       8114


<210>  5
<211>  7973
<212>  DNA
<213>  Homo sapiens

<400>  5
acaacgcgct ccctgcgggg cgggcggcaa cctccatgcg gcctcgtcca cgctcagcac       60

cggggaagcc gaggcggaga agccgcgcgc gcctcagaag ctcccggacg cccagcggcg      120

gcgcgagcgg cggcggcggc agcagcagca gcagcagcac ggccaccggc gggagcggca      180

gcagcaccgg cagccccggc ggcgcggcct cggccccggc cccggccccg gccggcatgt      240

atcgctccgg ggagcgcctg ctgggcagcc acgcgctgcc cgcggagcag cgggacttcc      300

tgcccctaga gacgaccaac aacaacaaca accaccacca gcccggggcc tgggcccgcc      360

gggcgggctc ctcggcgtcc tcgcctccct cggcgtcctc gtccccgcac ccttcggccg      420

ccgtccccgc cgccgatcca gccgattcgg cctcgggcag cagcaacaag aggaagcgcg      480

acaacaaggc cagcacgtat ggactcaact acagcctgct gcagcccagc ggagggcggg      540

ccgcgggggg cggccgagca gacggcggcg gggtcgtgta cagcgggacc ccgtggaaac      600

ggaggaacta caaccaggga gtcgtgggtc tgcatgaaga aatcagtgat ttttatgaat      660

acatgtctcc aagacctgag gaggagaaga tgcggatgga ggtggtgaac aggatcgaga      720

gtgtaattaa ggagctctgg cccagcgctg acgtccagat atttggaagt tttaaaactg      780

gactttattt acctactagt gacatcgacc tagtggtgtt tgggaagtgg gagaacctac      840

ccctctggac tctggaagaa gctcttcgga aacacaaagt cgcagatgag gattcggtga      900

aagttttaga caaagcaact gtacctatta ttaaattaac agattctttt actgaagtga      960

aagttgatat cagctttaat gtacagaatg gcgtgagagc agctgacctc atcaaagatt     1020

ttaccaagaa atatcctgta ttgccatact tggttttagt attgaaacaa ttcctattgc     1080

agagggacct taatgaagta tttacaggtg gaattggttc ttatagtctc tttttaatgg     1140

cagtcagttt ccttcagtta catcccaggg aagatgcttg catccccaat acaaactatg     1200

gtgttctctt aatagaattt tttgaattat atggacgaca cttcaattat ttaaagactg     1260

gcatccggat aaaggatggt ggttcatatg tggccaaaga tgaagtacag aaaaatatgc     1320

tagatggcta caggccatca atgctttata tcgaagatcc tttacaacca ggtaacgatg     1380

ttggaaggag ttcatatggg gccatgcaag tgaagcaggc ctttgattat gcctacgttg     1440

ttttgagtca tgctgtatca ccaatagcaa agtactatcc caacaatgaa acagaaagca     1500

tactaggtag aataattaga gtaacagatg aagttgccac atatagagat tggatatcaa     1560

agcagtgggg cttgaagaat agacctgagc cttcatgcaa tggtccagtg tcgtcctctt     1620

ctgccacaca gtccagctct agtgatgtag attccgatgc aacaccatgc aaaaccccga     1680

aacagctgct ttgccgtccg tccactggga accgagtagg gtcgcaagat gtatccttgg     1740

agtcctctca ggcagttggg aaaatgcaaa gcacccaaac cactaacaca tccaacagca     1800

ccaacaaatc tcagcatgga tcagcaaggc tctttcgttc ttccagcaaa ggcttccaag     1860

gtacaactca aacaagccat ggttccttga tgacaaacaa acaacatcaa ggcaaatcca     1920

ataatcagta ttaccatggc aaaaagagga aacacaagag ggacgcgccc ctctcagacc     1980

tctgtagata gtcagcgctg cgcggtggac tgtcttctct gtgcaatgat ctcatgctca     2040

ggacagttgc gcagggactc ctgggagata ttcaggagcc tcacactgtt cagacgttga     2100

cttagcaact gcgttttttc ccagctcgcc acagaatgga tcatgaagac tgacaactgc     2160

aaaaaaaaca aaacaaaaca aaaaaaaaag caagcaaaaa agagggaaaa aaaaggctgc     2220

ttatttgata agtcatatgc tacaacaggg tcattttaag atttaaagct tgaatgtaaa     2280

ataaatatat ttctcattgg ctttatgcag agttataggg aatagtattc agtgttggta     2340

gggtgataga aacaaaaaac agtatcagag gatgaggtgg ggaaggaaaa caaaggtatc     2400

tgataggaag tccagattcc aaaggggaaa gtgatctgtg catgtttttt ttttaaatat     2460

ttttgcatat atttaccatt ttattgtgtg tatatataga agaccatata ggagattgat     2520

atttgtaata gtggatttgt taataatact ttttacataa cattactgtt taaattgtaa     2580

acagattttt tctcaggatt agtttgaaaa ataatctaaa ttgtcatctt aacatccata     2640

tatagggaag tgattagttc tattactcaa tttgtttttc tcagcattga aatgacttaa     2700

tagaaccctt gtgtcctgct gcaaaaattt ttcctctcta aagaaaaggt ttatggtggc     2760

aaatgatgtt tattttattt tgtaaaaaaa aaaaaatgta ctatgtactt ttgtgtaaac     2820

actgaaaaat ctctggtcat ctccgagaat taacttgcaa ctgttttcta tagtgctgtc     2880

gtcttgggca atgggcaatt acatgacttt gtgtttgctt cctttgcagt cttttttttt     2940

tccccccatt tcttcctaat aggaaaaaaa aaaaaaaaaa ggtcacccat gtctggtctc     3000

attcctgttg cagtgaaact tcgagttcca cagactttgc atgctggctt ctctaaccct     3060

gtgtgctgcg tgtgcctgtt tctcatctct tattcttttt aaaattcatg cttaactact     3120

gtgggagaat aactgtaaac agctttaatt aaatcatact tataaaaaac tattttctta     3180

tattccactc tatgcttttg gtattgttga tctttacaaa ttaaatggtc tttgataatg     3240

gatctatttt gtattgcctt attaagacca aatacttctt gtcatcccat tctttatcct     3300

cttctttcat ggaattgtta tcgttaatta aaactttttt aaacattggc ttgtttcaat     3360

catactgtaa attttggttg tagtcagctt tgagtgcaat gagatgtata attctgttat     3420

cattacctgt tgagtttgaa actcagttgg gaatatttaa tataatagaa tgtaagtgac     3480

atttctgaaa atgctttctt tcagggtgaa agctcttatg tttagcatca atgtgtatgg     3540

ctctgttaaa tgcagccatt tctgagacga gattctttta tatatatata catataaagt     3600

actattggct tttaggagtt tcttttatat acatttatga aatactgaag accaatcaga     3660

ccattaatgg acacttagtg taacttttta taaagaaaat aatgctaaag taagaccaaa     3720

actgatgtca tcactgaaat taacaatttt caatatgttc atattttaat tcacaatgga     3780

aaaatgtgtt ccaaaactgg aaactcatag tactcgtgta aactgtggaa gatttcaaat     3840

gtgatgttat tttgacaatg ttttaaattt tagagtcaca ttttattctg atcagaattt     3900

ttattgagat gttgagcttt tgtttttgaa actagtttgt cataacattg tgcataatca     3960

cagtatttat tttctaggac aattgtgaat gtgtagactt atgtttactg ctaagggaac     4020

aattatttat aaaataatat taaatccagt attagctgcc tatttcagac acttaatact     4080

tgcagagatc tatgttacat ttaccacact gaagtttttt ttgttgtttt ttgtttgttt     4140

ttaaagaatc accctcattg ttgaaagtaa atgtactctt agggtgcgaa tattagtgtt     4200

ccaataagca tgtgattata ttaaggtggt ggtagcggga agataattct gattccattg     4260

ggaatcttag gttttcgtaa atttattggg aaaatagttt ttcctgtact gctgaagttt     4320

ctttttggta aacagtatct ttctaaaaga aaaaagcatg aaggagaaat tgaggtgtgt     4380

atacatttcc tcaaatgacc agcattgtat tcgtgaatac tgtgtatctt gcagtgaaca     4440

gtgtggaagc tgttcatttt tcaatctgaa gtaaaatact ttcaagaact tttagtttgc     4500

ctgctcattt gttttataca tttcatctat ttgactccta tcttatttct tttttgagtt     4560

ttaatacttc ctatattttg tgaatatatc agaaatgtgt catttatata ttagagtcca     4620

ttcatatcca tgaatcataa ccttcctttg ctaatacttg ttgaatggga ttttacaaat     4680

tctccctcac tctggtgaca tttctcaggc agtcatgtat gtgtacctgg ccattagaaa     4740

tattaatatt taaagactgt tttttagagg agctgatggg ttggtgaggt gtcagcacaa     4800

aatcttactg gttatgtttt gatgataaaa gtatatccat tttttccctc cagctttaag     4860

gtgactgtga aggtgcctgg ttttgaatgt ctttgtttgg tttggagatg tcgcactcag     4920

ttttcaaatc tagcttggat ctgtaggacc tatgtttttt acaagtaatt gccctccagt     4980

cttcaacagt tgattctgtt ttatttttat cctgttttga gtgtacttta cctttacttg     5040

cattttgagc ctcattaata tttaggttat ttgatttggc tccagatatt cctagatctg     5100

cacagggcaa aacatgggct atagggtgag catttttaat tgtctttttc tgctggaacc     5160

ttatatctct ccatgtgttt tctgctcctt ccctccccca tgaaatggta agtgtgactt     5220

gtgtttgcct gaacctgtgg actagtgttt ggggtttctg gaaacactag agggtcagaa     5280

aagagtaatg accaccgtga cgtgcaggat tctcttgctg tgacatgttc attgcaaagc     5340

cctctccagt gactaggagg tgtagttatt aaggttgatc tgttagaaat caccattatt     5400

aggtattagt ggtagatgtt gctgatactt ttattggtca tgactacatc tcagttttac     5460

tttaatattg atctatagtt tgatcagttc cttgaattct aatatgttga tttctcagtg     5520

tttctgtcac taaccaagaa tgtttctagg cagttggttg cttcacagtc aaaactaaat     5580

ggtaaactat caaaaataca ttcccaattt tgctgtgata aatattgaaa tgttaaaatt     5640

aatgaacaga agaatttatt cttacccatc tattcttgtt ctcctagttc attaaacttt     5700

cagttattgg aaaggcacat tctcaaagta ttttatgagc aaaatattct ataaatgcgt     5760

ctaacaaacc taattgaata taaaagttat atttagtagt tactgttgat agtaattttc     5820

atcagggtca tagttcatct agtaaaatat ttagagaatg atgttaacat tccagcatta     5880

aagtgggaac aaagatttat atatgaaatt ccttaaaaga gttcatcttg ccttggtttc     5940

tgaccctcaa gactctagct acctgccatc ttgtcaaaac atttgtgggt agaataagtg     6000

ttaaagatca aattttaata tgcttctcga tatttaacat agctaagaag ccagatttta     6060

ctgtagaagt tatttacatg atttgaaaac ttgacctaac tggaagcctt tttctcagtc     6120

atcttgttct aagccatctt gacttcacac ccttagcgac ttttcttttt tttttggtca     6180

aagataatga gctaaatata tatagacgtt gaatgttgac aaaattatta accagaaaaa     6240

ttgcttataa aggctgctga tctatttgat acctagaatt aaatatttga ggacagtttt     6300

tagttaataa actgctaatg tttattttac tgtctctcag gtttttggtt tttttaaaaa     6360

aaatgtgttt ggcctttaca ttttctactt aagtgtgtac tttattgagt ttaaccttgt     6420

ctgtagccta gtagcctgaa agaaaaggag acagaaccag agagatggat gtagtgcatt     6480

ccctttggtt attacacatt tgtggtagct cctggattta ctgagagata ttttagctat     6540

gtcaataaga acagctaatg atgtggaaat caggtgttct cttgtgtatt tcagtgaaca     6600

tttttattag tagttgcata tcatctctag ttccacattt taacttaacg tctttgtggc     6660

ttcaccactg agctaccttt cactacacca gcttctgtgt ggcctggtaa catggaaggt     6720

ctctcctaag gacagtctgg acgtattttg ggggaatgtt atttatctta aagatgccta     6780

gaaacaaaac gcatatagta ccagtgagaa actatgaagt aaacaagttg ctcaggccgg     6840

gcatggtggc tcacgcctgt aatcccagca ctttgggagg ccgaagcggg aggatggctt     6900

gaggctggga gtttgagacc ttcatctctt aaaaaaacaa acaaaaacct gaatggtgag     6960

gtgtggtgga attgggtagg ggagggaaag gaggacttgg aaaagcattc tccaaagcca     7020

gcaacttggt gaagttcagt acttgcctct tagaggttag gccatgcctt tcaaagagag     7080

tgaaatgatg ggttatcagc cacattcttg gagttaatat ttttcttcat ctttcagttt     7140

gggttctgtg ctattcatag ttcttcccta agaccatttc attattacct tttatattta     7200

gttgcaattt attataatat gttgttttgt ccctgaactt aatctcctaa ttttaagatc     7260

ctctctgatt tttgcatatt gaaacttaca gaagtcactt taaaaaagtc ttttgaaagt     7320

cctacaatcc taaaataaat cacaagcttg tttgttagac gtgtcaagag tctccagtct     7380

ttactactaa aaagcagcac tgccttaaca cacattgtta tgggtgaaaa gtgagggacg     7440

accagtgtag tttctggata taaagtgtga aggactgttg agttaaacat ttttagtgga     7500

atatacatag ataacgtgta tttagaaact ttggtgaagc cagtatttgt ttttagtaac     7560

ctttttatgt atttccttct ttgattagca ttgtcttcag tgttaagaaa tgtggactcc     7620

tgtgaggtgc tggaggtttg aatcatcttg aaaactttcc aatcttgtct agttaccact     7680

gcagagacac taaggaattt accagaaaaa gatatttgat acaagtgatt taagaaatct     7740

caacatttcc tgaggccgta tcactgggca accagtgatg aaaactatga atgaattgca     7800

cacctggaag attttttaag ctaatgacag tttcttcaaa gatgtcaatt atttgccttg     7860

gaaattttat aaattgcatt tctatgcaca tcggcctcta gtgcttacca ctcggtttat     7920

tattcataat ctgcaattca ataaaggctt tgtgttttca tttatcttca aaa            7973


<210>  6
<211>  4511
<212>  DNA
<213>  Homo sapiens

<400>  6
gggcgcgcgg gccccgcggg ggcggcgcgt ggatggatcc gcgcgtggcc tggatccagc       60

ccgagcagaa ggggccggcc aatgccctgt ggatgcagat ctgggagacc tcgcagggcg      120

tgggccgcgg cggctcgggc ttcgcgtcct atttctgcct caactcgccg gcgctggaca      180

cggcggccgc ggcgggggcg gccgggcggg gcagtggcgg cctgggcccc gcgctgcccg      240

ccgcgtcgcc cccgccgccc ggccccaccg cgcccgccgc gctgcccccc gcgctgctga      300

cggcgctggg gcccgcggcc gagggcgcgc ggcgcttgca caagtcgccg tcgctgtcgt      360

cctcgtcgtc gtcctcctcg tccaacgcgg agtcgggcac cgagagcccc ggctgctcgt      420

cgtcgtcctc cagcagcgcc tcgctgggcc ggccgggcgg cggccgcggc ggcgccttct      480

tcaacttcgc cgacggcgcg cccagcgccc ctggcacagc caacgggcac cccgggccgc      540

gcggccccgc gcccgccggc tccccgtcgc agcaccagtt ccacccgggt cgccggaaac      600

gcgagaacaa ggccagcacc tacggcctca actacctgct gtccggcagc cgcgcggccg      660

ctctcagcgg agggggcggc cccggggccc aggcgccgcg gcccggcacc ccgtggaaga      720

gccgcgcgta cagcccgggc atccagggac tacatgagga aataattgac ttttataact      780

tcatgtcccc ttgtcctgaa gaagcagcta tgagaagaga ggtggtgaaa cggatcgaaa      840

ctgtggtgaa agacctttgg ccgacggctg atgtacagat atttggcagc tttagtacag      900

gtctttatct tccaactagc gacatagacc tggtggtctt cgggaaatgg gagcgtcctc      960

ctttacagct gctggagcaa gccctgcgga agcacaacgt ggctgagccg tgttccatca     1020

aagtccttga caaggctacg gtaccaataa taaagctcac agatcaggag actgaagtga     1080

aagttgacat cagctttaac atggagacgg gcgtccgggc agcggagttc atcaagaatt     1140

acatgaagaa atattcattg ctgccttact tgattttagt attgaaacag ttccttctgc     1200

agagggacct gaatgaagtt tttacaggtg gaattagctc atacagccta attttaatgg     1260

ccattagctt tctacagttg catccaagaa ttgatgcccg gagagctgat gaaaaccttg     1320

gaatgcttct tgtagaattt tttgaactct atgggagaaa ttttaattac ttgaaaaccg     1380

gtattagaat caaagaagga ggtgcctata tcgccaaaga ggagatcatg aaagccatga     1440

ccagcgggta cagaccgtcg atgctgtgca ttgaggaccc cctgctgcca gggaatgacg     1500

ttggccggag ctcctatggc gccatgcagg tgaagcaggt cttcgattat gcctacatag     1560

tgctcagcca tgctgtgtca ccgctggcca ggtcctatcc aaacagagac gccgaaagta     1620

ctttaggaag aatcatcaaa gtaactcagg aggtgattga ctaccggagg tggatcaaag     1680

agaagtgggg cagcaaagcc cacccgtcgc caggcatgga cagcaggatc aagatcaaag     1740

agcgaatagc cacatgcaat ggggagcaga cgcagaaccg agagcccgag tctccctatg     1800

gccagcgctt gactttgtcg ctgtccagcc cccagctcct gtcttcaggc tcctcggcct     1860

cttctgtgtc ttcactttct gggagtgacg ttgattcaga cacaccgccc tgcacaacgc     1920

ccagtgttta ccagttcagt ctgcaagcgc cagctcctct catggccggc ttacccaccg     1980

ccttgccaat gcccagtggc aaacctcagc ccaccacttc cagaacactg atcatgacaa     2040

ccaacaatca gaccaggttt actatacctc caccgaccct aggggttgct cctgttcctt     2100

gcagacaagc tggtgtagaa ggaactgcgt ctttgaaagc cgtccaccac atgtcttccc     2160

cggccattcc ctcagcgtcc cccaacccgc tctcgagccc tcatctgtat cataagcagc     2220

acaacggcat gaaactgtcc atgaagggct ctcacggcca cacccaaggc ggcggctaca     2280

gctctgtggg tagcggaggt gtgcggcccc ctgtgggcaa caggggacac caccagtata     2340

accgcaccgg ctggaggagg aaaaaacaca cacacacacg ggacagtctg cccgtgagcc     2400

tcagcagata atggctcctg gctgcgtcag cctcccccac ccctctgcag actgccccgc     2460

ggcctcggcc accggcaggg gaaccgagac cagcaccccg cacgtcagcc gggctcgcgg     2520

cacgcccgcc gctgatcact ctgcatgttt cttcgtgtgg tggtcgcgtc catcttcaag     2580

aacagctcgt tgtgctcatc tgtgaagcct tattaaacgt ggacgttgtt ttctgccttc     2640

ccaggattct tccttcagtg ctgaggcagg tcgggctcag gaactgcagg gacgtgaaca     2700

tgcgcttgcg gtttgaggta gccgtgtctg ttccttcgcg gtttgctatt ttcatttcct     2760

gttcgtcaaa gcagcagagg agatcaaacc ccgttcgtgt gtctttcctc cacggataag     2820

cttgggaggt cattgtttta ctgccctcac attttgtttg aaatttcaga actgtttttc     2880

tatgtaaata ttgaaaactt atgatttgtg caataactca gatatttttt atttaatttc     2940

ctattttcac ataagttata tttaagggag gagggaattt tttttaaaca agcttaggtc     3000

ctttcccgag ctgcattttc taagttgggt catcgtgtcg gctggttgtc tgacgagcat     3060

cgttacaaac accatgatga ggggtttggg gttttatttt gatgtctttt cttttggtcg     3120

gaagtgagtg aaggagccag gtcgccctga aggttttcca aagggcttgg ctccagagcc     3180

acctggcaga ctgcccgtgg ccctgctgtc gggccccagg ccgttgtcct gctctgacca     3240

cagagtttta atgttttggt tttcacttct tttaaactgg acaacaaatc cagcatttca     3300

agtgccagaa gtataacttt ctaaggagag aagggttgtc acattataaa atctttagga     3360

aaatgtgaac tggaaaacgc ttcggtcagt tttagtgaca tagcctgtga tgatgggtct     3420

ggtgactatt attgcggacc gtggtaccca gttttaggaa tgtggagaaa ggaattctgt     3480

tgattccgtt gaggaatctg tagcgtatgc attcgttctg ttaagagcaa atctaggaga     3540

agtgcttcag ctgcccagtg cgccgtgggg agtgttttaa cggatcgtgt cgcaggagag     3600

cacagcccag cgttggggcc gggaccgctg gcgcccgacg tcggaagcat acaggtatac     3660

tatgcaagtg tattctgcca caacaaccac tgtctttgtt accttttttt gaacaagaat     3720

atatccatcc tgcctaaccc tgagtttttg gagcaccaca gttgtcctgg gagttggttg     3780

catcttgtag gccatctgac ttcctgtttt taaaacgggg gtctggtctt gctaaacact     3840

acaggtaggt tggtctttga agtccactag tggagaatgt caagacaaga tacttattac     3900

catgacatct gatgcatgtg cagcagtggg gagttctaga ttgatctctg aatgtgatcg     3960

acgcccagca aggacaagct ttaaaatgtc tgcggtctgc ccttttgaag caggactggc     4020

tcactctgtc attgggagct gtcagctgcg actgcaggtt ctctaggagg cattccagaa     4080

tagagtagca cactgtgtct gcagttctcg atgaccgaaa gttatcaaaa atatttaaaa     4140

tatttaaatt gtgaacctat tgataaagaa tatttataaa aactgatctg taggcctgta     4200

ctaatctcta cgcattagca atattgactg taaacccaca ttaaggaaac cactacgggt     4260

ctggcagtgc gtgtcccgtg gggtgtgcat tttaaaactc gattcataga cacaggtacc     4320

atgttccatt tccgtcatgg tgaagcaaat gaattggcct ggctaccact gtggtcgcgt     4380

gctacaggtt tgacaaaaag atatcatgtt tcgatttttt tgtgtgtgga caacaatatg     4440

gaagctaaaa ttgacatatt tttatgtaaa gtttttctat tctttgattt ttaataaact     4500

ttggaaacca g                                                          4511


<210>  7
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Tyr Gly Leu Asn Tyr Ser Leu Leu Gln Pro Ser Gly Gly Arg Ala 
1               5                   10                  15      


Ala Gly Gly Gly Arg Ala Asp Gly Gly Gly Val Val Tyr Ser Gly Thr 
            20                  25                  30          


Pro Trp Lys Arg Arg Asn Tyr Asn Gln Gly Val Val Gly Leu His Glu 
        35                  40                  45              


Glu Ile Ser Asp Phe Tyr Glu Tyr Met Ser Pro Arg Pro Glu Glu Glu 
    50                  55                  60                  


Lys Met Arg Met Glu Val Val Asn Arg Ile Glu Ser Val Ile Lys Glu 
65                  70                  75                  80  


Leu Trp Pro Ser Ala Asp Val Gln Ile Phe Gly Ser Phe Lys Thr Gly 
                85                  90                  95      


Leu Tyr Leu Pro Thr Ser Asp Ile Asp Leu Val Val Phe Gly Lys Trp 
            100                 105                 110         


Glu Asn Leu Pro Leu Trp Thr Leu Glu Glu Ala Leu Arg Lys His Lys 
        115                 120                 125             


Val Ala Asp Glu Asp Ser Val Lys Val Leu Asp Lys Ala Thr Val Pro 
    130                 135                 140                 


Ile Ile Lys Leu Thr Asp Ser Phe Thr Glu Val Lys Val Asp Ile Ser 
145                 150                 155                 160 


Phe Asn Val Gln Asn Gly Val Arg Ala Ala Asp Leu Ile Lys Asp Phe 
                165                 170                 175     


Thr Lys Lys Tyr Pro Val Leu Pro Tyr Leu Val Leu Val Leu Lys Gln 
            180                 185                 190         


Phe Leu Leu Gln Arg Asp Leu Asn Glu Val Phe Thr Gly Gly Ile Gly 
        195                 200                 205             


Ser Tyr Ser Leu Phe Leu Met Ala Val Ser Phe Leu Gln Leu His Pro 
    210                 215                 220                 


Arg Glu Asp Ala Cys Ile Pro Asn Thr Asn Tyr Gly Val Leu Leu Ile 
225                 230                 235                 240 


Glu Phe Phe Glu Leu Tyr Gly Arg His Phe Asn Tyr Leu Lys Thr Gly 
                245                 250                 255     


Ile Arg Ile Lys Asp Gly Gly Ser Tyr Val Ala Lys Asp Glu Val Gln 
            260                 265                 270         


Lys Asn Met Leu Asp Gly Tyr Arg Pro Ser Met Leu Tyr Ile Glu Asp 
        275                 280                 285             


Pro Leu Gln Pro Gly Asn Asp Val Gly Arg Ser Ser Tyr Gly Ala Met 
    290                 295                 300                 


Gln Val Lys Gln Ala Phe Asp Tyr Ala Tyr Val Val Leu Ser His Ala 
305                 310                 315                 320 


Val Ser Pro Ile Ala Lys Tyr Tyr Pro Asn Asn Glu Thr Glu Ser Ile 
                325                 330                 335     


Leu Gly Arg Ile Ile Arg Val Thr Asp Glu Val Ala Thr Tyr Arg Asp 
            340                 345                 350         


Trp Ile Ser Lys Gln Trp Gly Leu Lys Asn Arg Pro Glu Pro Ser Cys 
        355                 360                 365             


Asn Gly Asn Gly Val Thr Leu Ile Val Asp Thr Gln Gln Leu Asp Lys 
    370                 375                 380                 


Cys Asn Asn Asn Leu Ser Glu Glu Asn Glu Ala Leu Gly Lys Cys Arg 
385                 390                 395                 400 


Ser Lys Thr Ser Glu Ser Leu Ser Lys His Ser Ser Asn Ser Ser Ser 
                405                 410                 415     


Gly Pro Val Ser Ser Ser Ser Ala Thr Gln Ser Ser Ser Ser Asp Val 
            420                 425                 430         


Asp Ser Asp Ala Thr Pro Cys Lys Thr Pro Lys Gln Leu Leu Cys Arg 
        435                 440                 445             


Pro Ser Thr Gly Asn Arg Val Gly Ser Gln Asp Val Ser Leu Glu Ser 
    450                 455                 460                 


Ser Gln Ala Val Gly Lys Met Gln Ser Thr 
465                 470                 


<210>  8
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Leu Gln Pro Ser Gly Gly Arg Ala Ala Gly Gly Gly Arg Ala Asp 
1               5                   10                  15      


Gly Gly Gly Val Val Tyr Ser Gly Thr Pro Trp Lys Arg Arg Asn Tyr 
            20                  25                  30          


Asn Gln Gly Val Val Gly Leu His Glu Glu Ile Ser Asp Phe Tyr Glu 
        35                  40                  45              


Tyr Met Ser Pro Arg Pro Glu Glu Glu Lys Met Arg Met Glu Val Val 
    50                  55                  60                  


Asn Arg Ile Glu Ser Val Ile Lys Glu Leu Trp Pro Ser Ala Asp Val 
65                  70                  75                  80  


Gln Ile Phe Gly Ser Phe Lys Thr Gly Leu Tyr Leu Pro Thr Ser Asp 
                85                  90                  95      


Ile Asp Leu Val Val Phe Gly Lys Trp Glu Asn Leu Pro Leu Trp Thr 
            100                 105                 110         


Leu Glu Glu Ala Leu Arg Lys His Lys Val Ala Asp Glu Asp Ser Val 
        115                 120                 125             


Lys Val Leu Asp Lys Ala Thr Val Pro Ile Ile Lys Leu Thr Asp Ser 
    130                 135                 140                 


Phe Thr Glu Val Lys Val Asp Ile Ser Phe Asn Val Gln Asn Gly Val 
145                 150                 155                 160 


Arg Ala Ala Asp Leu Ile Lys Asp Phe Thr Lys Lys Tyr Pro Val Leu 
                165                 170                 175     


Pro Tyr Leu Val Leu Val Leu Lys Gln Phe Leu Leu Gln Arg Asp Leu 
            180                 185                 190         


Asn Glu Val Phe Thr Gly Gly Ile Gly Ser Tyr Ser Leu Phe Leu Met 
        195                 200                 205             


Ala Val Ser Phe Leu Gln Leu His Pro Arg Glu Asp Ala Cys Ile Pro 
    210                 215                 220                 


Asn Thr Asn Tyr Gly Val Leu Leu Ile Glu Phe Phe Glu Leu Tyr Gly 
225                 230                 235                 240 


Arg His Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Asp Gly Gly 
                245                 250                 255     


Ser Tyr Val Ala Lys Asp Glu Val Gln Lys Asn Met Leu Asp Gly Tyr 
            260                 265                 270         


Arg Pro Ser Met Leu Tyr Ile Glu Asp Pro Leu Gln Pro Gly Asn Asp 
        275                 280                 285             


Val Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Ala Phe Asp 
    290                 295                 300                 


Tyr Ala Tyr Val Val Leu Ser His Ala Val Ser Pro Ile Ala Lys Tyr 
305                 310                 315                 320 


Tyr Pro Asn Asn Glu Thr Glu Ser Ile Leu Gly Arg Ile Ile Arg Val 
                325                 330                 335     


Thr Asp Glu Val Ala Thr Tyr Arg Asp Trp Ile Ser Lys Gln Trp Gly 
            340                 345                 350         


Leu Lys Asn Arg Pro Glu Pro Ser Cys Asn Gly Pro Val Ser Ser Ser 
        355                 360                 365             


Ser Ala Thr Gln Ser Ser Ser Ser Asp Val Asp Ser Asp Ala Thr Pro 
    370                 375                 380                 


Cys Lys Thr Pro Lys Gln Leu Leu Cys Arg Pro Ser Thr Gly Asn Arg 
385                 390                 395                 400 


Val Gly Ser Gln Asp Val Ser Leu Glu Ser Ser Gln Ala Val Gly Lys 
                405                 410                 415     


Met Gln Ser 
            


<210>  9
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  9

Tyr Ser Pro Gly Ile Gln Gly Leu His Glu Glu Ile Ile Asp Phe Tyr 
1               5                   10                  15      


Asn Phe Met Ser Pro Cys Pro Glu Glu Ala Ala Met Arg Arg Glu Val 
            20                  25                  30          


Val Lys Arg Ile Glu Thr Val Val Lys Asp Leu Trp Pro Thr Ala Asp 
        35                  40                  45              


Val Gln Ile Phe Gly Ser Phe Ser Thr Gly Leu Tyr Leu Pro Thr Ser 
    50                  55                  60                  


Asp Ile Asp Leu Val Val Phe Gly Lys Trp Glu Arg Pro Pro Leu Gln 
65                  70                  75                  80  


Leu Leu Glu Gln Ala Leu Arg Lys His Asn Val Ala Glu Pro Cys Ser 
                85                  90                  95      


Ile Lys Val Leu Asp Lys Ala Thr Val Pro Ile Ile Lys Leu Thr Asp 
            100                 105                 110         


Gln Glu Thr Glu Val Lys Val Asp Ile Ser Phe Asn Met Glu Thr Gly 
        115                 120                 125             


Val Arg Ala Ala Glu Phe Ile Lys Asn Tyr Met Lys Lys Tyr Ser Leu 
    130                 135                 140                 


Leu Pro Tyr Leu Ile Leu Val Leu Lys Gln Phe Leu Leu Gln Arg Asp 
145                 150                 155                 160 


Leu Asn Glu Val Phe Thr Gly Gly Ile Ser Ser Tyr Ser Leu Ile Leu 
                165                 170                 175     


Met Ala Ile Ser Phe Leu Gln Leu His Pro Arg Ile Asp Ala Arg Arg 
            180                 185                 190         


Ala Asp Glu Asn Leu Gly Met Leu Leu Val Glu Phe Phe Glu Leu Tyr 
        195                 200                 205             


Gly Arg Asn Phe Asn Tyr Leu Lys Thr Gly Ile Arg Ile Lys Glu Gly 
    210                 215                 220                 


Gly Ala Tyr Ile Ala Lys Glu Glu Ile Met Lys Ala Met Thr Ser Gly 
225                 230                 235                 240 


Tyr Arg Pro Ser Met Leu Cys Ile Glu Asp Pro Leu Leu Pro Gly Asn 
                245                 250                 255     


Asp Val Gly Arg Ser Ser Tyr Gly Ala Met Gln Val Lys Gln Val Phe 
            260                 265                 270         


Asp Tyr Ala Tyr Ile Val Leu Ser His Ala Val Ser Pro Leu Ala Arg 
        275                 280                 285             


Ser Tyr Pro Asn Arg Asp Ala Glu Ser Thr Leu Gly Arg Ile Ile Lys 
    290                 295                 300                 


Val Thr Gln Glu Val Ile Asp Tyr Arg Arg Trp Ile Lys Glu Lys Trp 
305                 310                 315                 320 


<210>  10
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Human PAPD5 target RNA

<400>  10
caucaaugcu uuauaucga                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Human PAPD5 target RNA

<400>  11
ggacgacacu ucaauuauu                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  Human PAPD5 RNA target sequence

<400>  12
gauaaaggau ggugguuca                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  human PAPD5 Target mRNA sequence

<400>  13
gaauagaccu gagccuuca                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  human PAPD7 target mRNA sequence

<400>  14
ggagugacgu ugauucaga                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  human PAPD7 target mRNA sequence

<400>  15
cggaguucau caagaauua                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  human PAPD7 target RNA sequence

<400>  16
cggaguucau caagaauua                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  human PAPD7 target mRNA sequence

<400>  17
gcgaauagcc acaugcaau                                                    19


<210>  18
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  18
ctgtgccttg ggtggcttt                                                    19


<210>  19
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  19
aaggaaagaa gtcagaaggc aaaa                                              24


<210>  20
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  probe

<400>  20
ttctttataa gggtcgatgt ccatg                                             25


