                         SEQUENCE LISTING

<110>  Charit Berlin
       Charit Berlin, Medizinische Universitt Innsbruck
 
<120>  Neuropeptide-Expressing Vectors and Methods for the Treatment of 
       Epilepsy

<130>  C75042WO

<150>  16174827.2
<151>  2016-06-16

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Gly Phe Leu Arg Lys Tyr Pro Lys Arg Ser Ser Glu Val Ala Gly Glu 
            180                 185                 190         


Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr Lys Arg Tyr Gly 
        195                 200                 205             


Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn Gln Lys 
    210                 215                 220                 


Arg Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg Ser 
225                 230                 235                 240 


Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
                245                 250                 


<210>  2
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg Ser Gln Glu Asp 
            180                 185                 190         


Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala Lys Arg Ser Ser Glu 
        195                 200                 205             


Val Ala Gly Glu Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr 
    210                 215                 220                 


Lys Arg Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp 
225                 230                 235                 240 


Asp Asn Gln Lys Arg Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val 
                245                 250                 255     


Val Thr Arg Ser Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe 
            260                 265                 270         


Asp Ala 
        


<210>  3
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg Ser Gln Glu Asp 
            180                 185                 190         


Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala Lys Arg Ser Ser Glu 
        195                 200                 205             


Val Ala Gly Glu Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr 
    210                 215                 220                 


Lys Arg Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg 
225                 230                 235                 240 


Ser Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala Lys 
                245                 250                 255     


Arg Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg Ser 
            260                 265                 270         


Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
        275                 280                 285     


<210>  4
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala 
            20  


<210>  5
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys Thr Gln Asp Gly 
1               5                   10                  15      


Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln Cys Gln Ala Ala 
            20                  25                  30          


Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser Phe Leu Ser Phe 
        35                  40                  45              


Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu Asp Leu Gly Ser 
    50                  55                  60                  


Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala Lys Leu Ser Gly 
65                  70                  75                  80  


Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu Pro Ser Ile Ser 
                85                  90                  95      


Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu Lys Leu Arg Gly 
            100                 105                 110         


Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu Leu Met Arg Asp 
        115                 120                 125             


Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr Leu Tyr Leu Ala 
    130                 135                 140                 


Glu Glu Asp Pro Lys Glu Gln Val 
145                 150         


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  6

Tyr Gly Gly Phe Leu Arg Lys Tyr Pro 
1               5                   


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn 
1               5                   10                  15      


Gln 
    


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  8

Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr 
1               5                   10              


<210>  9
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  9

Tyr Gly Gly Phe Leu Arg Arg Gln Phe Lys Val Val Thr Arg Ser Gln 
1               5                   10                  15      


Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
            20                  25                  


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Tyr Gly Glx Phe Leu Arg Arg Glx Arg Pro Lys Leu Lys Trp Asp Asn 
1               5                   10                  15      


Gln 
    


<210>  11
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  11

Tyr Gly Glx Phe Leu Arg Arg Glx Phe Lys Val Val Thr 
1               5                   10                     




<210>  12
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  12

Tyr Gly Glx Phe Leu Arg Arg Glx Phe Lys Val Val Thr Arg Ser Gln 
1               5                   10                  15      


Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
            20                  25                  


<210>  13
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Gly Phe Leu Arg Lys Tyr Pro Lys Arg Ser Ser Glu Val Ala Gly Glu 
            180                 185                 190         


Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr Lys Arg Tyr Gly 
        195                 200                 205             


Glx Phe Leu Arg Arg Glx Arg Glx Lys Leu Lys Trp Asp Asn Gln Lys 
    210                 215                 220                 


Arg Tyr Gly Glx Phe Leu Arg Arg Glx Phe Lys Val Val Thr Arg Ser 
225                 230                 235                 240 


Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
                245                 250                 


<210>  14
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Glx Phe Leu Arg Arg Glx Phe Lys Val Val Thr Arg Ser Gln Glu Asp 
            180                 185                 190         


Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala Lys Arg Ser Ser Glu 
        195                 200                 205             


Val Ala Gly Glu Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr 
    210                 215                 220                 


Lys Arg Tyr Gly Glx Phe Leu Arg Arg Glx Arg Glx Lys Leu Lys Trp 
225                 230                 235                 240 


Asp Asn Gln Lys Arg Tyr Gly Glx Phe Leu Arg Arg Glx Phe Lys Val 
                245                 250                 255     


Val Thr Arg Ser Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe 
            260                 265                 270         


Asp Ala 
        


<210>  15
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Trp Gln Gly Leu Val Leu Ala Ala Cys Leu Leu Met Phe Pro 
1               5                   10                  15      


Ser Thr Thr Ala Asp Cys Leu Ser Arg Cys Ser Leu Cys Ala Val Lys 
            20                  25                  30          


Thr Gln Asp Gly Pro Lys Pro Ile Asn Pro Leu Ile Cys Ser Leu Gln 
        35                  40                  45              


Cys Gln Ala Ala Leu Leu Pro Ser Glu Glu Trp Glu Arg Cys Gln Ser 
    50                  55                  60                  


Phe Leu Ser Phe Phe Thr Pro Ser Thr Leu Gly Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Asp Leu Gly Ser Lys Ser Val Gly Glu Gly Pro Tyr Ser Glu Leu Ala 
                85                  90                  95      


Lys Leu Ser Gly Ser Phe Leu Lys Glu Leu Glu Lys Ser Lys Phe Leu 
            100                 105                 110         


Pro Ser Ile Ser Thr Lys Glu Asn Thr Leu Ser Lys Ser Leu Glu Glu 
        115                 120                 125             


Lys Leu Arg Gly Leu Ser Asp Gly Phe Arg Glu Gly Ala Glu Ser Glu 
    130                 135                 140                 


Leu Met Arg Asp Ala Gln Leu Asn Asp Gly Ala Met Glu Thr Gly Thr 
145                 150                 155                 160 


Leu Tyr Leu Ala Glu Glu Asp Pro Lys Glu Gln Val Lys Arg Tyr Gly 
                165                 170                 175     


Glx Phe Leu Arg Arg Glx Phe Lys Val Val Thr Arg Ser Gln Glu Asp 
            180                 185                 190         


Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala Lys Arg Ser Ser Glu 
        195                 200                 205             


Val Ala Gly Glu Gly Asp Gly Asp Ser Met Gly His Glu Asp Leu Tyr 
    210                 215                 220                 


Lys Arg Tyr Gly Glx Phe Leu Arg Arg Glx Phe Lys Val Val Thr Arg 
225                 230                 235                 240 


Ser Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala Lys 
                245                 250                 255     


Arg Tyr Gly Glx Phe Leu Arg Arg Glx Phe Lys Val Val Thr Arg Ser 
            260                 265                 270         


Gln Glu Asp Pro Asn Ala Tyr Ser Gly Glu Leu Phe Asp Ala 
        275                 280                 285     


