                         SEQUENCE LISTING

<110>  GlaxoSmithKline Biologicals S.A.
 
<120>  Immunogenic Composition

<130>  VB66120

<140>  1610599.1
<141>  2016-06-17

<160>  120   

<170>  PatentIn version 3.5

<210>  1
<211>  471
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  1

Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  2
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  2

Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys 
1               5                   10                  15      


Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile 
            20                  25                  30          


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
        35                  40                  45              


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr 
    50                  55                  60                  


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
                85                  90                  95      


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
            100                 105                 110         


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
        115                 120                 125             


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
    130                 135                 140                 


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
145                 150                 155                 160 


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
                165                 170                 175     


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
            180                 185                 190         


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
        195                 200                 205             


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
    210                 215                 220                 


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
225                 230                 235                 240 


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
                245                 250                 255     


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
            260                 265                 270         


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
        275                 280                 285             


Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
    290                 295                 300                 


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
305                 310                 315                 320 


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
                325                 330                 335     


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
            340                 345                 350         


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
        355                 360                 365             


Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
    370                 375                 380                 


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
385                 390                 395                 400 


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
                405                 410                 415     


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp 
            420                 425                 430         


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
        435                 440                 445             


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
    450                 455                 460                 


Leu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
465                 470                 475     


<210>  3
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  3

Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys 
1               5                   10                  15      


Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile 
            20                  25                  30          


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
        35                  40                  45              


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys 
    50                  55                  60                  


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
                85                  90                  95      


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
            100                 105                 110         


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
        115                 120                 125             


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
    130                 135                 140                 


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
145                 150                 155                 160 


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
                165                 170                 175     


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
            180                 185                 190         


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
        195                 200                 205             


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
    210                 215                 220                 


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
225                 230                 235                 240 


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
                245                 250                 255     


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
            260                 265                 270         


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
        275                 280                 285             


Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
    290                 295                 300                 


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
305                 310                 315                 320 


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
                325                 330                 335     


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
            340                 345                 350         


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
        355                 360                 365             


Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
    370                 375                 380                 


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
385                 390                 395                 400 


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
                405                 410                 415     


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp 
            420                 425                 430         


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
        435                 440                 445             


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
    450                 455                 460                 


Leu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
465                 470                 475     


<210>  4
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  4

Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys 
1               5                   10                  15      


Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile 
            20                  25                  30          


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
        35                  40                  45              


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr 
    50                  55                  60                  


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
                85                  90                  95      


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
            100                 105                 110         


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
        115                 120                 125             


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
    130                 135                 140                 


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
145                 150                 155                 160 


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
                165                 170                 175     


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
            180                 185                 190         


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
        195                 200                 205             


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
    210                 215                 220                 


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
225                 230                 235                 240 


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
                245                 250                 255     


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
            260                 265                 270         


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
        275                 280                 285             


Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
    290                 295                 300                 


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
305                 310                 315                 320 


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
                325                 330                 335     


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
            340                 345                 350         


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
        355                 360                 365             


Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
    370                 375                 380                 


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
385                 390                 395                 400 


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
                405                 410                 415     


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp 
            420                 425                 430         


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
        435                 440                 445             


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
    450                 455                 460                 


Leu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
465                 470                 475     


<210>  5
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  5

Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys 
1               5                   10                  15      


Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile 
            20                  25                  30          


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
        35                  40                  45              


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr 
    50                  55                  60                  


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
                85                  90                  95      


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
            100                 105                 110         


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
        115                 120                 125             


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
    130                 135                 140                 


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
145                 150                 155                 160 


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
                165                 170                 175     


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
            180                 185                 190         


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
        195                 200                 205             


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
    210                 215                 220                 


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
225                 230                 235                 240 


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
                245                 250                 255     


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
            260                 265                 270         


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
        275                 280                 285             


Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
    290                 295                 300                 


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
305                 310                 315                 320 


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
                325                 330                 335     


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
            340                 345                 350         


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
        355                 360                 365             


Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
    370                 375                 380                 


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
385                 390                 395                 400 


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
                405                 410                 415     


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp 
            420                 425                 430         


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
        435                 440                 445             


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
    450                 455                 460                 


Leu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
465                 470                 475     


<210>  6
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  6

Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys 
1               5                   10                  15      


Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile 
            20                  25                  30          


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
        35                  40                  45              


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr 
    50                  55                  60                  


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
                85                  90                  95      


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
            100                 105                 110         


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
        115                 120                 125             


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
    130                 135                 140                 


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
145                 150                 155                 160 


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
                165                 170                 175     


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
            180                 185                 190         


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
        195                 200                 205             


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
    210                 215                 220                 


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
225                 230                 235                 240 


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
                245                 250                 255     


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
            260                 265                 270         


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
        275                 280                 285             


Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
    290                 295                 300                 


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
305                 310                 315                 320 


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
                325                 330                 335     


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
            340                 345                 350         


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
        355                 360                 365             


Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
    370                 375                 380                 


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
385                 390                 395                 400 


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
                405                 410                 415     


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Trp 
            420                 425                 430         


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
        435                 440                 445             


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
    450                 455                 460                 


Leu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
465                 470                 475     


<210>  7
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  7

Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys 
1               5                   10                  15      


Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile 
            20                  25                  30          


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
        35                  40                  45              


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr 
    50                  55                  60                  


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
                85                  90                  95      


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
            100                 105                 110         


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
        115                 120                 125             


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
    130                 135                 140                 


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
145                 150                 155                 160 


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
                165                 170                 175     


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
            180                 185                 190         


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
        195                 200                 205             


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
    210                 215                 220                 


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
225                 230                 235                 240 


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
                245                 250                 255     


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
            260                 265                 270         


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
        275                 280                 285             


Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
    290                 295                 300                 


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
305                 310                 315                 320 


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
                325                 330                 335     


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
            340                 345                 350         


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
        355                 360                 365             


Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
    370                 375                 380                 


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
385                 390                 395                 400 


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
                405                 410                 415     


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Glu 
            420                 425                 430         


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
        435                 440                 445             


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
    450                 455                 460                 


Leu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
465                 470                 475     


<210>  8
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  8

Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys 
1               5                   10                  15      


Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile 
            20                  25                  30          


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
        35                  40                  45              


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr 
    50                  55                  60                  


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
                85                  90                  95      


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
            100                 105                 110         


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
        115                 120                 125             


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
    130                 135                 140                 


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
145                 150                 155                 160 


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
                165                 170                 175     


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
            180                 185                 190         


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
        195                 200                 205             


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
    210                 215                 220                 


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
225                 230                 235                 240 


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
                245                 250                 255     


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
            260                 265                 270         


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
        275                 280                 285             


Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
    290                 295                 300                 


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
305                 310                 315                 320 


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
                325                 330                 335     


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
            340                 345                 350         


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
        355                 360                 365             


Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
    370                 375                 380                 


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
385                 390                 395                 400 


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
                405                 410                 415     


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp 
            420                 425                 430         


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
        435                 440                 445             


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
    450                 455                 460                 


Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
465                 470                 475     


<210>  9
<211>  477
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  9

Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala 
            420                 425                 430         


Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys 
        435                 440                 445             


Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr 
    450                 455                 460                 


Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
465                 470                 475         


<210>  10
<211>  476
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  10

Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys 
1               5                   10                  15      


Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile 
            20                  25                  30          


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
        35                  40                  45              


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys 
    50                  55                  60                  


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
                85                  90                  95      


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
            100                 105                 110         


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
        115                 120                 125             


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
    130                 135                 140                 


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
145                 150                 155                 160 


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
                165                 170                 175     


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
            180                 185                 190         


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
        195                 200                 205             


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
    210                 215                 220                 


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
225                 230                 235                 240 


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
                245                 250                 255     


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
            260                 265                 270         


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
        275                 280                 285             


Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
    290                 295                 300                 


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
305                 310                 315                 320 


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
                325                 330                 335     


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
            340                 345                 350         


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
        355                 360                 365             


Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
    370                 375                 380                 


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
385                 390                 395                 400 


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
                405                 410                 415     


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu 
            420                 425                 430         


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
        435                 440                 445             


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
    450                 455                 460                 


Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
465                 470                 475     


<210>  11
<211>  483
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  11

Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala 
            420                 425                 430         


Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys 
        435                 440                 445             


Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr 
    450                 455                 460                 


Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp His His His 
465                 470                 475                 480 


His His His 
            


<210>  12
<211>  482
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  12

Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys 
1               5                   10                  15      


Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile 
            20                  25                  30          


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
        35                  40                  45              


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys 
    50                  55                  60                  


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
                85                  90                  95      


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
            100                 105                 110         


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
        115                 120                 125             


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
    130                 135                 140                 


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
145                 150                 155                 160 


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
                165                 170                 175     


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
            180                 185                 190         


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
        195                 200                 205             


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
    210                 215                 220                 


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
225                 230                 235                 240 


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
                245                 250                 255     


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
            260                 265                 270         


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
        275                 280                 285             


Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
    290                 295                 300                 


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
305                 310                 315                 320 


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
                325                 330                 335     


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
            340                 345                 350         


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
        355                 360                 365             


Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
    370                 375                 380                 


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
385                 390                 395                 400 


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
                405                 410                 415     


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu 
            420                 425                 430         


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
        435                 440                 445             


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
    450                 455                 460                 


Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp His His His His 
465                 470                 475                 480 


His His 
        


<210>  13
<211>  19
<212>  PRT
<213>  E. Coli

<400>  13

Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala 
            


<210>  14
<211>  21
<212>  PRT
<213>  E. Coli

<400>  14

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala 
            20      


<210>  15
<211>  26
<212>  PRT
<213>  E. Coli

<400>  15

Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala 
            20                  25      


<210>  16
<211>  22
<212>  PRT
<213>  E. Carotova

<400>  16

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  17
<211>  23
<212>  PRT
<213>  E. Coli

<400>  17

Met Ser Phe Lys Lys Ile Ile Lys Ala Phe Val Ile Met Ala Ala Leu 
1               5                   10                  15      


Val Ser Val Gln Ala His Ala 
            20              


<210>  18
<211>  28
<212>  PRT
<213>  B. endoxylanase

<400>  18

Met Phe Lys Phe Lys Lys Lys Phe Leu Val Gly Leu Thr Ala Ala Phe 
1               5                   10                  15      


Met Ser Ile Ser Met Phe Ser Ala Thr Ala Ser Ala 
            20                  25              


<210>  19
<211>  19
<212>  PRT
<213>  E. Coli

<400>  19

Met Ile Lys Phe Leu Ser Ala Leu Ile Leu Leu Leu Val Thr Thr Ala 
1               5                   10                  15      


Ala Gln Ala 
            


<210>  20
<211>  21
<212>  PRT
<213>  E. Coli

<400>  20

Met Lys Gln Ala Leu Arg Val Ala Phe Gly Phe Leu Ile Leu Trp Ala 
1               5                   10                  15      


Ser Val Leu His Ala 
            20      


<210>  21
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  21

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr 
            340                 345                 350         


Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser 
        355                 360                 365             


Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu 
    370                 375                 380                 


Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp 
385                 390                 395                 400 


Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys 
                405                 410                 415     


Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser 
            420                 425                 430         


Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu 
        435                 440                 445             


Ala Thr Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  22
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  22

Met Lys Gln Ala Leu Arg Val Ala Phe Gly Phe Leu Ile Leu Trp Ala 
1               5                   10                  15      


Ser Val Leu His Ala Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr 
            340                 345                 350         


Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser 
        355                 360                 365             


Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu 
    370                 375                 380                 


Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp 
385                 390                 395                 400 


Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys 
                405                 410                 415     


Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser 
            420                 425                 430         


Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu 
        435                 440                 445             


Ala Thr Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  23
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val" or "Pro"

<400>  23

Xaa Thr Gly Leu Ala Xaa Lys Asp Gln Asn Ala Thr Lys 
1               5                   10              


<210>  24
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val" or "Pro"

<400>  24

Xaa Thr Gly Leu Ala Xaa Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg 
1               5                   10                  15      


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
            20                  25                  30          


Ser Ile Trp Gly Thr Thr Xaa 
        35                  


<210>  25
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val" or "Pro"

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Xaa Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
1               5                   10                  15      


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
            20                  25                  30          


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
        35                  40                  45              


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Xaa Thr Gly Leu Ala Xaa 
    50                  55                  60                  


Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr 
65                  70                  75                  80  


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
                85                  90                  95      


Xaa 
    


<210>  26
<211>  174
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (141)..(141)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (174)..(174)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (174)..(174)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val" or "Pro"

<400>  26

Xaa Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp 
1               5                   10                  15      


Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His 
            20                  25                  30          


Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val 
        35                  40                  45              


Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr 
    50                  55                  60                  


Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Xaa Tyr Val 
65                  70                  75                  80  


Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly 
                85                  90                  95      


Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu 
            100                 105                 110         


Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn 
        115                 120                 125             


Leu Ser Val Lys Ile Arg Glu Xaa Thr Gly Leu Ala Xaa Lys Asp Gln 
    130                 135                 140                 


Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro 
145                 150                 155                 160 


Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Xaa 
                165                 170                 


<210>  27
<211>  402
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  misc_feature
<222>  (229)..(229)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (238)..(238)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  misc_feature
<222>  (306)..(306)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (315)..(315)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  misc_feature
<222>  (364)..(364)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (365)..(365)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (368)..(368)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Asx" or "Cys" or "Gln" 
       or "Glu" or "Glx" or "Gly" or "His" or "Ile" or "Leu" or "Lys" or
       "Met" or "Phe" or "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  misc_feature
<222>  (369)..(369)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (401)..(401)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val" or "Pro"

<220>
<221>  MISC_FEATURE
<222>  (402)..(402)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val" or "Pro"

<400>  27

Xaa Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
1               5                   10                  15      


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
            20                  25                  30          


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
        35                  40                  45              


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
    50                  55                  60                  


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
65                  70                  75                  80  


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
                85                  90                  95      


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
            100                 105                 110         


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
        115                 120                 125             


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
    130                 135                 140                 


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
145                 150                 155                 160 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
                165                 170                 175     


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
            180                 185                 190         


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
        195                 200                 205             


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
    210                 215                 220                 


Ala Val Ile Leu Xaa Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
225                 230                 235                 240 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
                245                 250                 255     


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
            260                 265                 270         


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
        275                 280                 285             


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
    290                 295                 300                 


Gly Xaa Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
305                 310                 315                 320 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
                325                 330                 335     


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
            340                 345                 350         


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Xaa Thr Gly Leu Ala 
        355                 360                 365             


Xaa Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys 
    370                 375                 380                 


Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr 
385                 390                 395                 400 


Thr Xaa 
        


<210>  28
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa="Asp" or "Glu"

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa="Ser" or "Thr"

<400>  28

Xaa Xaa Asn Glx Xaa 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  29

Asp Gln Asn Ala Thr 
1               5   


<210>  30
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa="Asp" or "Glu"

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa="Ala" or "Arg" or "Asn" or "Asp" or "Cys" or "Gln" or "Glu" 
       or "Gly" or "His" or "Ile" or "Leu" or "Lys" or "Met" or "Phe" or
       "Ser" or "Thr" or "Trp" or "Tyr" or "Val"

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa="Ser" or "Thr"

<400>  30

Lys Xaa Xaa Asn Glx Xaa Lys 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  31

Lys Asp Gln Asn Ala Thr Lys 
1               5           


<210>  32
<211>  498
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  32

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Val Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr 
            340                 345                 350         


Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser 
        355                 360                 365             


Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu 
    370                 375                 380                 


Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp 
385                 390                 395                 400 


Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys 
                405                 410                 415     


Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser 
            420                 425                 430         


Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu 
        435                 440                 445             


Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr 
    450                 455                 460                 


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
465                 470                 475                 480 


Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp His His His His 
                485                 490                 495     


His His 
        


<210>  33
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  33

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Asp Gln Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu 
        35                  40                  45              


Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn 
    50                  55                  60                  


Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu 
65                  70                  75                  80  


Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr Asn Asp Ser Arg 
                85                  90                  95      


Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn 
            100                 105                 110         


Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile 
        115                 120                 125             


Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  34
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  34

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Lys Asp Gln Asn 
        35                  40                  45              


Ala Thr Lys Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn 
    50                  55                  60                  


Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu 
65                  70                  75                  80  


Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr Asn Asp Ser Arg 
                85                  90                  95      


Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn 
            100                 105                 110         


Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile 
        115                 120                 125             


Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  35
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  35

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Lys 
        35                  40                  45              


Asp Gln Asn Ala Thr Lys Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn 
    50                  55                  60                  


Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu 
65                  70                  75                  80  


Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr Asn Asp Ser Arg 
                85                  90                  95      


Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn 
            100                 105                 110         


Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile 
        115                 120                 125             


Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  36
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  36

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Lys Asp Gln Asn Ala Thr Lys Asn Arg Phe Ile Lys Glu Gly Asn 
    50                  55                  60                  


Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu 
65                  70                  75                  80  


Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr Asn Asp Ser Arg 
                85                  90                  95      


Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn 
            100                 105                 110         


Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile 
        115                 120                 125             


Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  37
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  37

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Lys Asp Gln Asn Ala Thr Lys Asn Arg Phe Ile Lys Glu Gly Asn 
    50                  55                  60                  


Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu 
65                  70                  75                  80  


Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr Asn Asp Ser Arg 
                85                  90                  95      


Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn 
            100                 105                 110         


Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile 
        115                 120                 125             


Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  38
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  38

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Lys Asp Gln Asn Ala Thr Lys Asp Ser Phe Leu Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  39
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  39

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Lys Asp Gln Asn Ala Thr Lys Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  40
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  40

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Lys Asp Gln Asn Ala Thr Lys Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  41
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  41

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Lys Asp Gln Asn Ala Thr Lys Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  42
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  42

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Lys Asp Gln Asn Ala Thr Lys Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  43
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  43

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Asp Gln Asn Ala Thr Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  44
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  44

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Asp Gln Asn Ala 
    290                 295                 300                 


Thr Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Val 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  45
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  45

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Val Gly Asp Lys Asp Gln Asn 
305                 310                 315                 320 


Ala Thr Lys Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  46
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  46

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Val Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Lys Asp Gln Asn Ala Thr Lys Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  47
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  47

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Val Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Lys Asp Gln Asn Ala Thr Lys Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  48
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  48

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Val Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Lys Asp Gln Asn Ala Thr Lys 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  49
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  49

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Val Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr 
            340                 345                 350         


Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser 
        355                 360                 365             


Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu 
    370                 375                 380                 


Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp 
385                 390                 395                 400 


Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys 
                405                 410                 415     


Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser 
            420                 425                 430         


Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu 
        435                 440                 445             


Ala Thr Gly Lys Asp Gln Asn Ala Thr Lys Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  50
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  50

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Val Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr 
            340                 345                 350         


Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser 
        355                 360                 365             


Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu 
    370                 375                 380                 


Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp 
385                 390                 395                 400 


Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys 
                405                 410                 415     


Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser 
            420                 425                 430         


Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu 
        435                 440                 445             


Ala Thr Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  51
<211>  498
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  51

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr 
            340                 345                 350         


Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser 
        355                 360                 365             


Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu 
    370                 375                 380                 


Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp 
385                 390                 395                 400 


Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys 
                405                 410                 415     


Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser 
            420                 425                 430         


Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu 
        435                 440                 445             


Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr 
    450                 455                 460                 


Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr 
465                 470                 475                 480 


Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp His His His His 
                485                 490                 495     


His His 
        


<210>  52
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  52

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Lys Asp Gln Asn 
        35                  40                  45              


Ala Thr Lys Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn 
    50                  55                  60                  


Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu 
65                  70                  75                  80  


Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys Asn Asp Ser Arg 
                85                  90                  95      


Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn 
            100                 105                 110         


Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile 
        115                 120                 125             


Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Cys 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  53
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  53

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr 
            340                 345                 350         


Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser 
        355                 360                 365             


Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu 
    370                 375                 380                 


Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp 
385                 390                 395                 400 


Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys 
                405                 410                 415     


Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser 
            420                 425                 430         


Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu 
        435                 440                 445             


Ala Thr Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  54
<211>  502
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  54

Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met 
            20                  25                  30          


Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Lys Asp Gln Asn Ala Thr 
        35                  40                  45              


Lys Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu 
    50                  55                  60                  


Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr 
65                  70                  75                  80  


Asn Thr Ser Asp Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr 
                85                  90                  95      


Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro 
            100                 105                 110         


Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu 
        115                 120                 125             


Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser 
    130                 135                 140                 


Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His 
145                 150                 155                 160 


Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu 
                165                 170                 175     


Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser 
            180                 185                 190         


Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val 
        195                 200                 205             


His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr 
    210                 215                 220                 


Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln 
225                 230                 235                 240 


Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu 
                245                 250                 255     


Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr 
            260                 265                 270         


Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe 
        275                 280                 285             


Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys 
    290                 295                 300                 


Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp 
305                 310                 315                 320 


Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu 
                325                 330                 335     


Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu 
            340                 345                 350         


Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr 
        355                 360                 365             


Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg 
    370                 375                 380                 


Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr 
385                 390                 395                 400 


Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val 
                405                 410                 415     


Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His 
            420                 425                 430         


Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val 
        435                 440                 445             


Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg Thr Val 
    450                 455                 460                 


Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile 
465                 470                 475                 480 


Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
                485                 490                 495     


His His His His His His 
            500         


<210>  55
<211>  502
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  55

Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met 
            20                  25                  30          


Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu 
        35                  40                  45              


Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val 
    50                  55                  60                  


Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser 
65                  70                  75                  80  


Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val 
                85                  90                  95      


Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp 
            100                 105                 110         


Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser 
        115                 120                 125             


Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly 
    130                 135                 140                 


Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val 
145                 150                 155                 160 


Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser 
                165                 170                 175     


Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly 
            180                 185                 190         


Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln 
        195                 200                 205             


Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp 
    210                 215                 220                 


Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu 
225                 230                 235                 240 


Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile 
                245                 250                 255     


Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr 
            260                 265                 270         


Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly 
        275                 280                 285             


Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr 
    290                 295                 300                 


Glu Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg 
305                 310                 315                 320 


Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly 
                325                 330                 335     


Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr 
            340                 345                 350         


Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp 
        355                 360                 365             


Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu 
    370                 375                 380                 


Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu 
385                 390                 395                 400 


Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp 
                405                 410                 415     


Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro 
            420                 425                 430         


Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr 
        435                 440                 445             


Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val 
    450                 455                 460                 


Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile 
465                 470                 475                 480 


Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
                485                 490                 495     


His His His His His His 
            500         


<210>  56
<211>  502
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  56

Met Ile Lys Phe Leu Ser Ala Leu Ile Leu Leu Leu Val Thr Thr Ala 
1               5                   10                  15      


Ala Gln Ala Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met 
            20                  25                  30          


Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Lys Asp Gln Asn Ala Thr 
        35                  40                  45              


Lys Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu 
    50                  55                  60                  


Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr 
65                  70                  75                  80  


Asn Thr Ser Asp Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr 
                85                  90                  95      


Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro 
            100                 105                 110         


Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu 
        115                 120                 125             


Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser 
    130                 135                 140                 


Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His 
145                 150                 155                 160 


Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu 
                165                 170                 175     


Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser 
            180                 185                 190         


Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val 
        195                 200                 205             


His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr 
    210                 215                 220                 


Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln 
225                 230                 235                 240 


Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu 
                245                 250                 255     


Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr 
            260                 265                 270         


Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe 
        275                 280                 285             


Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys 
    290                 295                 300                 


Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp 
305                 310                 315                 320 


Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu 
                325                 330                 335     


Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu 
            340                 345                 350         


Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr 
        355                 360                 365             


Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg 
    370                 375                 380                 


Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr 
385                 390                 395                 400 


Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val 
                405                 410                 415     


Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His 
            420                 425                 430         


Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val 
        435                 440                 445             


Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg Thr Val 
    450                 455                 460                 


Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile 
465                 470                 475                 480 


Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
                485                 490                 495     


His His His His His His 
            500         


<210>  57
<211>  502
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  57

Met Ile Lys Phe Leu Ser Ala Leu Ile Leu Leu Leu Val Thr Thr Ala 
1               5                   10                  15      


Ala Gln Ala Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met 
            20                  25                  30          


Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu 
        35                  40                  45              


Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val 
    50                  55                  60                  


Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser 
65                  70                  75                  80  


Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val 
                85                  90                  95      


Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp 
            100                 105                 110         


Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser 
        115                 120                 125             


Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly 
    130                 135                 140                 


Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val 
145                 150                 155                 160 


Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser 
                165                 170                 175     


Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly 
            180                 185                 190         


Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln 
        195                 200                 205             


Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp 
    210                 215                 220                 


Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu 
225                 230                 235                 240 


Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile 
                245                 250                 255     


Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr 
            260                 265                 270         


Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly 
        275                 280                 285             


Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr 
    290                 295                 300                 


Glu Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg 
305                 310                 315                 320 


Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly 
                325                 330                 335     


Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr 
            340                 345                 350         


Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp 
        355                 360                 365             


Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu 
    370                 375                 380                 


Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu 
385                 390                 395                 400 


Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp 
                405                 410                 415     


Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro 
            420                 425                 430         


Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr 
        435                 440                 445             


Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg Thr Val 
    450                 455                 460                 


Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile Ser Ile 
465                 470                 475                 480 


Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu Asn Asp 
                485                 490                 495     


His His His His His His 
            500         


<210>  58
<211>  506
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  58

Met Ser Phe Lys Lys Ile Ile Lys Ala Phe Val Ile Met Ala Ala Leu 
1               5                   10                  15      


Val Ser Val Gln Ala His Ala Ser Ala Asn Lys Ala Val Asn Asp Phe 
            20                  25                  30          


Ile Leu Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Lys Asp 
        35                  40                  45              


Gln Asn Ala Thr Lys Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu 
    50                  55                  60                  


Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg 
65                  70                  75                  80  


Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys Asn Asp 
                85                  90                  95      


Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu 
            100                 105                 110         


Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr 
        115                 120                 125             


Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val 
    130                 135                 140                 


Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu 
145                 150                 155                 160 


Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg 
                165                 170                 175     


Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val 
            180                 185                 190         


Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp 
        195                 200                 205             


Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe 
    210                 215                 220                 


Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly 
225                 230                 235                 240 


Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly 
                245                 250                 255     


Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly 
            260                 265                 270         


Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val 
        275                 280                 285             


Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln 
    290                 295                 300                 


Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile 
305                 310                 315                 320 


Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val 
                325                 330                 335     


Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp 
            340                 345                 350         


His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn 
        355                 360                 365             


Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val 
    370                 375                 380                 


Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr 
385                 390                 395                 400 


Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln 
                405                 410                 415     


Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp 
            420                 425                 430         


Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg 
        435                 440                 445             


Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp 
    450                 455                 460                 


Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg 
465                 470                 475                 480 


Thr Ile Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys 
                485                 490                 495     


Val Glu Asn Asp His His His His His His 
            500                 505     


<210>  59
<211>  506
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  59

Met Ser Phe Lys Lys Ile Ile Lys Ala Phe Val Ile Met Ala Ala Leu 
1               5                   10                  15      


Val Ser Val Gln Ala His Ala Ser Ala Asn Lys Ala Val Asn Asp Phe 
            20                  25                  30          


Ile Leu Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly 
        35                  40                  45              


Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp 
    50                  55                  60                  


Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr 
65                  70                  75                  80  


Ser Asp Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly 
                85                  90                  95      


Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu 
            100                 105                 110         


Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly 
        115                 120                 125             


Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser 
    130                 135                 140                 


Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp 
145                 150                 155                 160 


Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile 
                165                 170                 175     


Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe 
            180                 185                 190         


Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser 
        195                 200                 205             


Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr 
    210                 215                 220                 


Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr 
225                 230                 235                 240 


Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro 
                245                 250                 255     


Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys 
            260                 265                 270         


Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala 
        275                 280                 285             


Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile 
    290                 295                 300                 


Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser 
305                 310                 315                 320 


Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu 
                325                 330                 335     


Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile 
            340                 345                 350         


Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln 
        355                 360                 365             


Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly 
    370                 375                 380                 


Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile 
385                 390                 395                 400 


Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr 
                405                 410                 415     


Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr 
            420                 425                 430         


Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile 
        435                 440                 445             


Arg Glu Ala Thr Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr Lys Trp 
    450                 455                 460                 


Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg 
465                 470                 475                 480 


Thr Ile Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys 
                485                 490                 495     


Val Glu Asn Asp His His His His His His 
            500                 505     


<210>  60
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  60

Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala Ser Ala Asn Lys Ala Val 
            20                  25                  30          


Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr 
        35                  40                  45              


His Lys Asp Gln Asn Ala Thr Lys Gly Glu Ser Ile Glu Asn Arg Phe 
    50                  55                  60                  


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
65                  70                  75                  80  


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
                85                  90                  95      


Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
            100                 105                 110         


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
        115                 120                 125             


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
    130                 135                 140                 


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
145                 150                 155                 160 


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
                165                 170                 175     


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
            180                 185                 190         


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
        195                 200                 205             


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
    210                 215                 220                 


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
225                 230                 235                 240 


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
                245                 250                 255     


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
            260                 265                 270         


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
        275                 280                 285             


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
    290                 295                 300                 


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
305                 310                 315                 320 


Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
                325                 330                 335     


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
            340                 345                 350         


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
        355                 360                 365             


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
    370                 375                 380                 


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
385                 390                 395                 400 


Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
                405                 410                 415     


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
            420                 425                 430         


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
        435                 440                 445             


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala 
    450                 455                 460                 


Glu Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
465                 470                 475                 480 


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val 
                485                 490                 495     


Glu Asp Lys Val Glu Asn Asp His His His His His His 
            500                 505                 


<210>  61
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  61

Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala Ser Ala Asn Lys Ala Val 
            20                  25                  30          


Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr 
        35                  40                  45              


His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln 
    50                  55                  60                  


Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser 
65                  70                  75                  80  


Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu 
                85                  90                  95      


Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn 
            100                 105                 110         


Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp 
        115                 120                 125             


Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro 
    130                 135                 140                 


Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp 
145                 150                 155                 160 


His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr 
                165                 170                 175     


Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe Gly 
            180                 185                 190         


Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser 
        195                 200                 205             


Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile 
    210                 215                 220                 


Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe 
225                 230                 235                 240 


Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala 
                245                 250                 255     


Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val 
            260                 265                 270         


Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala 
        275                 280                 285             


Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp 
    290                 295                 300                 


Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly 
305                 310                 315                 320 


Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met Val 
                325                 330                 335     


Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly 
            340                 345                 350         


Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala 
        355                 360                 365             


Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr 
    370                 375                 380                 


Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln 
385                 390                 395                 400 


Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu 
                405                 410                 415     


Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala 
            420                 425                 430         


His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser 
        435                 440                 445             


Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Lys Asp Gln Asn Ala 
    450                 455                 460                 


Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
465                 470                 475                 480 


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val 
                485                 490                 495     


Glu Asp Lys Val Glu Asn Asp His His His His His His 
            500                 505                 


<210>  62
<211>  508
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  62

Met Lys Met Asn Lys Lys Val Leu Leu Thr Ser Thr Met Ala Ala Ser 
1               5                   10                  15      


Leu Leu Ser Val Ala Ser Val Gln Ala Ser Ala Asn Lys Ala Val Asn 
            20                  25                  30          


Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His 
        35                  40                  45              


Lys Asp Gln Asn Ala Thr Lys Gly Glu Ser Ile Glu Asn Arg Phe Ile 
    50                  55                  60                  


Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys 
65                  70                  75                  80  


Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys 
                85                  90                  95      


Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr 
            100                 105                 110         


Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met 
        115                 120                 125             


Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu 
    130                 135                 140                 


Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp 
145                 150                 155                 160 


Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro 
                165                 170                 175     


Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu 
            180                 185                 190         


Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp 
        195                 200                 205             


Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val 
    210                 215                 220                 


Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn 
225                 230                 235                 240 


Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln 
                245                 250                 255     


Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala 
            260                 265                 270         


Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp 
        275                 280                 285             


Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala 
    290                 295                 300                 


Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala 
305                 310                 315                 320 


Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly 
                325                 330                 335     


Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr 
            340                 345                 350         


Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg 
        355                 360                 365             


Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr 
    370                 375                 380                 


Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly 
385                 390                 395                 400 


Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp 
                405                 410                 415     


His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly 
            420                 425                 430         


Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn 
        435                 440                 445             


Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu 
    450                 455                 460                 


Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg 
465                 470                 475                 480 


Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu 
                485                 490                 495     


Asp Lys Val Glu Asn Asp His His His His His His 
            500                 505             


<210>  63
<211>  508
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  63

Met Lys Met Asn Lys Lys Val Leu Leu Thr Ser Thr Met Ala Ala Ser 
1               5                   10                  15      


Leu Leu Ser Val Ala Ser Val Gln Ala Ser Ala Asn Lys Ala Val Asn 
            20                  25                  30          


Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His 
        35                  40                  45              


Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu 
    50                  55                  60                  


Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr 
65                  70                  75                  80  


Asn Thr Ser Asp Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr 
                85                  90                  95      


Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro 
            100                 105                 110         


Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu 
        115                 120                 125             


Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser 
    130                 135                 140                 


Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His 
145                 150                 155                 160 


Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu 
                165                 170                 175     


Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser 
            180                 185                 190         


Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val 
        195                 200                 205             


His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr 
    210                 215                 220                 


Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln 
225                 230                 235                 240 


Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu 
                245                 250                 255     


Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr 
            260                 265                 270         


Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe 
        275                 280                 285             


Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys 
    290                 295                 300                 


Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp 
305                 310                 315                 320 


Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu 
                325                 330                 335     


Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu 
            340                 345                 350         


Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr 
        355                 360                 365             


Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg 
    370                 375                 380                 


Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr 
385                 390                 395                 400 


Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val 
                405                 410                 415     


Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His 
            420                 425                 430         


Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val 
        435                 440                 445             


Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr 
    450                 455                 460                 


Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg 
465                 470                 475                 480 


Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu 
                485                 490                 495     


Asp Lys Val Glu Asn Asp His His His His His His 
            500                 505             


<210>  64
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  64

Met Phe Lys Phe Lys Lys Lys Phe Leu Val Gly Leu Thr Ala Ala Phe 
1               5                   10                  15      


Met Ser Ile Ser Met Phe Ser Ala Thr Ala Ser Ala Ser Ala Asn Lys 
            20                  25                  30          


Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys Lys Lys Leu 
        35                  40                  45              


Leu Thr His Lys Asp Gln Asn Ala Thr Lys Gly Glu Ser Ile Glu Asn 
    50                  55                  60                  


Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile 
65                  70                  75                  80  


Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val 
                85                  90                  95      


Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val 
            100                 105                 110         


Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg 
        115                 120                 125             


Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp 
    130                 135                 140                 


Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala 
145                 150                 155                 160 


Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn 
                165                 170                 175     


Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met 
            180                 185                 190         


Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn 
        195                 200                 205             


Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile 
    210                 215                 220                 


Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala 
225                 230                 235                 240 


Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp 
                245                 250                 255     


Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser 
            260                 265                 270         


Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser 
        275                 280                 285             


Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val 
    290                 295                 300                 


Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu 
305                 310                 315                 320 


Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly Ala Arg Val 
                325                 330                 335     


Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser 
            340                 345                 350         


Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser 
        355                 360                 365             


Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr 
    370                 375                 380                 


Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp 
385                 390                 395                 400 


His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu 
                405                 410                 415     


Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp 
            420                 425                 430         


Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu 
        435                 440                 445             


Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Ala Thr Gly 
    450                 455                 460                 


Leu Ala Glu Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro 
465                 470                 475                 480 


Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Glu Tyr Pro 
                485                 490                 495     


Gln Val Glu Asp Lys Val Glu Asn Asp His His His His His His 
            500                 505                 510     


<210>  65
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  65

Met Phe Lys Phe Lys Lys Lys Phe Leu Val Gly Leu Thr Ala Ala Phe 
1               5                   10                  15      


Met Ser Ile Ser Met Phe Ser Ala Thr Ala Ser Ala Ser Ala Asn Lys 
            20                  25                  30          


Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys Lys Lys Leu 
        35                  40                  45              


Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly 
    50                  55                  60                  


Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser 
65                  70                  75                  80  


Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys Asn Asp Ser 
                85                  90                  95      


Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu 
            100                 105                 110         


Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser 
        115                 120                 125             


Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu 
    130                 135                 140                 


Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala 
145                 150                 155                 160 


Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met 
                165                 170                 175     


Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys 
            180                 185                 190         


Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe 
        195                 200                 205             


Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys 
    210                 215                 220                 


Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp 
225                 230                 235                 240 


Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile 
                245                 250                 255     


Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg 
            260                 265                 270         


Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu 
        275                 280                 285             


Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr 
    290                 295                 300                 


Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu 
305                 310                 315                 320 


Cys Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp 
                325                 330                 335     


Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His 
            340                 345                 350         


Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val 
        355                 360                 365             


Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr 
    370                 375                 380                 


Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val 
385                 390                 395                 400 


Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly 
                405                 410                 415     


Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu 
            420                 425                 430         


Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn 
        435                 440                 445             


Leu Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Lys Asp Gln 
    450                 455                 460                 


Asn Ala Thr Lys Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro 
465                 470                 475                 480 


Leu Val Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Glu Tyr Pro 
                485                 490                 495     


Gln Val Glu Asp Lys Val Glu Asn Asp His His His His His His 
            500                 505                 510     


<210>  66
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  66

Met Lys Gln Ala Leu Arg Val Ala Phe Gly Phe Leu Ile Leu Trp Ala 
1               5                   10                  15      


Ser Val Leu His Ala Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Lys Asp Gln Asn 
        35                  40                  45              


Ala Thr Lys Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn 
    50                  55                  60                  


Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu 
65                  70                  75                  80  


Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys Asn Asp Ser Arg 
                85                  90                  95      


Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn 
            100                 105                 110         


Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile 
        115                 120                 125             


Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Cys 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  67
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  67

Met Lys Gln Ala Leu Arg Val Ala Phe Gly Phe Leu Ile Leu Trp Ala 
1               5                   10                  15      


Ser Val Leu His Ala Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr 
            340                 345                 350         


Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser 
        355                 360                 365             


Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu 
    370                 375                 380                 


Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp 
385                 390                 395                 400 


Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys 
                405                 410                 415     


Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser 
            420                 425                 430         


Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu 
        435                 440                 445             


Ala Thr Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  68
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  68

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Lys Asp Gln Asn 
        35                  40                  45              


Ala Thr Lys Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn 
    50                  55                  60                  


Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys Arg Ser Leu 
65                  70                  75                  80  


Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Cys Asn Asp Ser Arg 
                85                  90                  95      


Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu Leu Glu Asn 
            100                 105                 110         


Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr Tyr Ser Ile 
        115                 120                 125             


Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln Val Glu Asp 
    130                 135                 140                 


Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu Leu Ala Lys 
145                 150                 155                 160 


Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala Arg Met Gln 
                165                 170                 175     


Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys Val Lys Phe 
            180                 185                 190         


Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn 
        195                 200                 205             


Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn Phe Lys Gln 
    210                 215                 220                 


Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro Gly Asp Val 
225                 230                 235                 240 


Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg Gly Ile Ser 
                245                 250                 255     


Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln 
            260                 265                 270         


Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu Val Glu Ala 
        275                 280                 285             


Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro Gln Thr Glu 
    290                 295                 300                 


Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val Ile Leu Cys 
305                 310                 315                 320 


Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys Val Asp Met 
                325                 330                 335     


Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala Asp His Pro 
            340                 345                 350         


Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp Asn Val Val 
        355                 360                 365             


Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys Val Thr Ala 
    370                 375                 380                 


Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Glu Tyr Val Ala 
385                 390                 395                 400 


Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His Gln Gly Lys 
                405                 410                 415     


Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr 
            420                 425                 430         


Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val Arg Asn Leu 
        435                 440                 445             


Ser Val Lys Ile Arg Glu Ala Thr Gly Leu Ala Glu Glu Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  69
<211>  504
<212>  PRT
<213>  Artificial

<220>
<223>  Modified pneumolysin

<400>  69

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Ser Ala Asn Lys Ala Val Asn Asp Phe Ile Leu 
            20                  25                  30          


Ala Met Asn Tyr Asp Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser 
        35                  40                  45              


Ile Glu Asn Arg Phe Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe 
    50                  55                  60                  


Val Val Ile Glu Arg Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp 
65                  70                  75                  80  


Ile Ser Val Thr Ala Cys Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu 
                85                  90                  95      


Leu Val Val Asp Glu Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala 
            100                 105                 110         


Val Asp Arg Ala Pro Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala 
        115                 120                 125             


Ser Ser Asp Ser Phe Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val 
    130                 135                 140                 


Arg Gly Ala Val Asn Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly 
145                 150                 155                 160 


Gln Val Asn Asn Val Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala 
                165                 170                 175     


His Ser Met Glu Gln Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys 
            180                 185                 190         


Thr Gly Asn Ser Leu Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu 
        195                 200                 205             


Lys Gln Ile Gln Ile Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser 
    210                 215                 220                 


Val Asp Ala Val Lys Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr 
225                 230                 235                 240 


Val Glu Asp Leu Lys Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val 
                245                 250                 255     


Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu 
            260                 265                 270         


Thr Thr Ser Lys Ser Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile 
        275                 280                 285             


Lys Gly Val Lys Val Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp 
    290                 295                 300                 


Asn Thr Glu Val Lys Ala Val Ile Leu Cys Gly Asp Pro Ser Ser Gly 
305                 310                 315                 320 


Ala Arg Val Val Thr Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln 
                325                 330                 335     


Glu Gly Ser Arg Phe Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr 
            340                 345                 350         


Thr Thr Ser Phe Leu Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser 
        355                 360                 365             


Thr Asp Tyr Val Glu Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu 
    370                 375                 380                 


Leu Leu Asp His Ser Gly Glu Tyr Val Ala Gln Tyr Tyr Ile Thr Trp 
385                 390                 395                 400 


Asn Glu Leu Ser Tyr Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys 
                405                 410                 415     


Ala Trp Asp Arg Asn Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser 
            420                 425                 430         


Ile Pro Leu Lys Gly Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu 
        435                 440                 445             


Ala Thr Gly Leu Ala Glu Lys Asp Gln Asn Ala Thr Lys Trp Trp Arg 
    450                 455                 460                 


Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys Arg Thr Ile 
465                 470                 475                 480 


Ser Ile Trp Gly Thr Thr Glu Tyr Pro Gln Val Glu Asp Lys Val Glu 
                485                 490                 495     


Asn Asp His His His His His His 
            500                 


<210>  70
<211>  26
<212>  PRT
<213>  E. Coli

<400>  70

Met Lys Met Asn Lys Lys Val Leu Leu Thr Ser Thr Met Ala Ala Ser 
1               5                   10                  15      


Leu Leu Ser Val Ala Ser Val Gln Ala Ser 
            20                  25      


<210>  71
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  71

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Met Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ser Leu Ile Lys Gly Val Ala Pro 
            260                 265                 270         


Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val 
        275                 280                 285             


Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys 
    290                 295                 300                 


Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala 
305                 310                 315                 320 


Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp 
                325                 330                 335     


Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys 
            340                 345                 350         


Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Ala 
        355                 360                 365             


Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His 
    370                 375                 380                 


Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln 
385                 390                 395                 400 


Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val 
                405                 410                 415     


Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp Glu 
            420                 425                 430         


Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys 
        435                 440                 445             


Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val Glu Asp 
    450                 455                 460                 


Lys Val Glu Asn Asp 
465                 


<210>  72
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  72

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Met Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  73
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  73

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ala Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  74
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  74

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  75
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  75

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  76
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  76

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  77
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  77

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  78
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  78

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  79
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  79

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  80
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  80

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  81
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  81

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  82
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  82

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  83
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  83

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  84
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  84

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  85
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  85

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  86
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  86

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  87
<211>  471
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  87

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  88
<211>  469
<212>  PRT
<213>  Artificial

<220>
<223>  Streptococcus pneumoniae

<400>  88

Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp Lys Lys 
1               5                   10                  15      


Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe Ile Lys 
            20                  25                  30          


Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg Lys Lys 
        35                  40                  45              


Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala Thr Asn 
    50                  55                  60                  


Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu Thr Leu 
65                  70                  75                  80  


Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro Met Thr 
                85                  90                  95      


Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe Leu Gln 
            100                 105                 110         


Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn Asp Leu 
        115                 120                 125             


Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val Pro Ala 
    130                 135                 140                 


Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln Leu Lys 
145                 150                 155                 160 


Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu Asp Ile 
                165                 170                 175     


Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile Val Asn 
            180                 185                 190         


Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys Asn Pro 
        195                 200                 205             


Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys Gln Arg 
    210                 215                 220                 


Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val Ala Tyr 
225                 230                 235                 240 


Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser Asp Glu 
                245                 250                 255     


Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val Ala Pro 
            260                 265                 270         


Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys Ala Val 
        275                 280                 285             


Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr Gly Lys 
    290                 295                 300                 


Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe Thr Ala 
305                 310                 315                 320 


Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu Arg Asp 
                325                 330                 335     


Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu Thr Lys 
            340                 345                 350         


Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser Gly Ala 
        355                 360                 365             


Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr Asp His 
    370                 375                 380                 


Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn Gly Gln 
385                 390                 395                 400 


Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly Asn Val 
                405                 410                 415     


Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala Trp Glu 
            420                 425                 430         


Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val Arg Lys 
        435                 440                 445             


Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val Glu Asp 
    450                 455                 460                 


Lys Val Glu Asn Asp 
465                 


<210>  89
<211>  300
<212>  PRT
<213>  E. coli

<400>  89

Met Thr Val Ile Ala Ile Val Val Thr Phe Asn Arg Cys Ala Leu Leu 
1               5                   10                  15      


Lys Lys Val Leu His Ser Leu Leu Ser Gln Ser Ile Ala Leu Asn Lys 
            20                  25                  30          


Ile Ile Ile Ile Asp Asn Asp Ser Asn Asp Asp Thr Ala Lys Val Val 
        35                  40                  45              


His Asp Phe Ser Glu Val Asp Asp Ile Phe Tyr Tyr Tyr Asn Thr Gly 
    50                  55                  60                  


Asp Asn Leu Gly Gly Ala Gly Gly Phe Tyr Gln Gly Phe Lys Ile Ala 
65                  70                  75                  80  


Glu Gln Leu Tyr Tyr Asp Tyr Leu Trp Leu Met Asp Asp Asp Leu Leu 
                85                  90                  95      


Pro Glu Pro Asp Cys Leu Glu Lys Leu Ile Gln Asp Arg Pro Glu Gly 
            100                 105                 110         


Ile Val Gln Pro Val Arg Tyr Asp Leu Asp Gly Ala Cys Ala Glu Ile 
        115                 120                 125             


Ser Pro Val Glu Tyr Asn Leu Gln Lys Ile Phe Cys Arg Asn Pro Lys 
    130                 135                 140                 


Thr Lys Thr Val Lys Glu Val Ile Ser Thr Val Ile Ser Asp Asn Cys 
145                 150                 155                 160 


Arg Glu Ile Asp Ile Ala Gly Val Pro Phe Glu Gly Pro Leu Ile Ser 
                165                 170                 175     


Lys Ser Val Val Asn Lys Val Gly Tyr Pro Asn Pro Asp Phe Phe Ile 
            180                 185                 190         


Phe Asn Asp Asp Leu Asp Tyr Ser Leu Arg Thr Arg Ser Lys Gly Phe 
        195                 200                 205             


Ser Ile Lys Cys Ile Val Asp Ala Arg Ala Thr Arg Leu Leu Lys Asn 
    210                 215                 220                 


Asn Gln Lys Asn Asp Leu Lys Ser Trp Lys Gly Tyr Phe Met Leu Arg 
225                 230                 235                 240 


Asn His Tyr Tyr Ile Leu Arg Asn Tyr Gly Glu Asn Lys Leu Val Lys 
                245                 250                 255     


Asn Arg Val Tyr Leu Ile Met Phe Tyr Tyr Phe Leu Lys Ser Val Phe 
            260                 265                 270         


Ser Phe Asp Tyr Lys Phe Ala Lys Val Val Ile Phe Ser Phe Lys Asp 
        275                 280                 285             


Ser Phe Ser Leu Lys Asn Ser Lys Arg Phe Arg Pro 
    290                 295                 300 


<210>  90
<211>  305
<212>  PRT
<213>  E. coli

<400>  90

Met Ser Ile Thr Asn Lys Thr Ile Ala Leu Val Ile Val Thr Tyr Asn 
1               5                   10                  15      


Arg Cys Asn Leu Leu Met Glu Met Leu Ser Ser Ile Glu Asn Met Ser 
            20                  25                  30          


Val Lys Pro Asp Ile Val Tyr Val Ile Asp Asn Asn Ser Ser Asp Asn 
        35                  40                  45              


Thr Ser Ser Val Val Thr Glu Cys Asp Ser Arg Lys Asn Ile Asn Ile 
    50                  55                  60                  


Lys Tyr His Asn Thr Gly Tyr Asn Ala Gly Gly Ala Gly Gly Phe Tyr 
65                  70                  75                  80  


Ile Gly Ser Lys Met Ala Tyr Glu Asp Gly Trp Asp Arg Ile Trp Leu 
                85                  90                  95      


Ala Asp Asp Asp Ile Val Leu Asp Lys Glu Cys Leu Ser Asn Ala Met 
            100                 105                 110         


Glu Tyr Asp Asp Gly Arg Thr Ile Leu Gln Pro Met Arg Tyr Asn Met 
        115                 120                 125             


Asp Gly Ser Cys Ala Glu Ile Ser Ala Ile Gln Tyr Asp Leu Ser Asn 
    130                 135                 140                 


Pro Phe Tyr Leu Arg Pro Lys Arg Lys Thr Val Gln Asn Ile Phe Asn 
145                 150                 155                 160 


Lys Asn Ile Leu Ser Tyr Asp Ile Gln Ser Ile Pro Phe Glu Gly Pro 
                165                 170                 175     


Ile Ile Pro Arg Glu Val Phe Asn Val Ile Gly Phe Pro Asp Glu Arg 
            180                 185                 190         


Phe Phe Ile Phe Asn Asp Asp Leu Asp Phe Ala Ile Arg Ala Gln Arg 
        195                 200                 205             


Ala Gly Phe Ser Ile Lys Cys Ile Thr Asn Ala Lys Ile Val Arg Lys 
    210                 215                 220                 


Ile Pro Phe Val Gln Ser Val Ala Leu Lys Thr Trp Lys Gly Tyr Phe 
225                 230                 235                 240 


Met Phe Arg Asn Tyr Phe Arg Val Gln Lys Val Tyr Gly Leu Ser Pro 
                245                 250                 255     


Leu Ile Tyr Leu Arg Ile Leu Leu Val Phe Cys Leu Ala Leu Gly His 
            260                 265                 270         


Ser Leu Val Arg Met Asp Ile Asn Ser Ile Lys Met Leu Cys Gly Ala 
        275                 280                 285             


Leu Lys Asp Gly Leu Ser Gln Glu Phe Lys Leu Thr Glu Lys Tyr Lys 
    290                 295                 300                 


Pro 
305 


<210>  91
<211>  481
<212>  PRT
<213>  S. pneumoniae

<400>  91

Met Ser Arg Arg Phe Lys Lys Ser Arg Ser Gln Lys Val Lys Arg Ser 
1               5                   10                  15      


Val Asn Ile Val Leu Leu Thr Ile Tyr Leu Leu Leu Val Cys Phe Leu 
            20                  25                  30          


Leu Phe Leu Ile Phe Lys Tyr Asn Ile Leu Ala Phe Arg Tyr Leu Asn 
        35                  40                  45              


Leu Val Val Thr Ala Leu Val Leu Leu Val Ala Leu Val Gly Leu Leu 
    50                  55                  60                  


Leu Ile Ile Tyr Lys Lys Ala Glu Lys Phe Thr Ile Phe Leu Leu Val 
65                  70                  75                  80  


Phe Ser Ile Leu Val Ser Ser Val Ser Leu Phe Ala Val Gln Gln Phe 
                85                  90                  95      


Val Gly Leu Thr Asn Arg Leu Asn Ala Thr Ser Asn Tyr Ser Glu Tyr 
            100                 105                 110         


Ser Ile Ser Val Ala Val Leu Ala Asp Ser Glu Ile Glu Asn Val Thr 
        115                 120                 125             


Gln Leu Thr Ser Val Thr Ala Pro Thr Gly Thr Asn Asn Glu Asn Ile 
    130                 135                 140                 


Gln Lys Leu Leu Ala Asp Ile Lys Ser Ser Gln Asn Thr Asp Leu Thr 
145                 150                 155                 160 


Val Asn Gln Ser Ser Ser Tyr Leu Ala Ala Tyr Lys Ser Leu Ile Ala 
                165                 170                 175     


Gly Glu Thr Lys Ala Ile Val Leu Asn Ser Val Phe Glu Asn Ile Ile 
            180                 185                 190         


Glu Ser Glu Tyr Pro Asp Tyr Ala Ser Lys Ile Lys Lys Ile Tyr Thr 
        195                 200                 205             


Lys Gly Phe Thr Lys Lys Val Glu Ala Pro Lys Thr Ser Lys Ser Gln 
    210                 215                 220                 


Ser Phe Asn Ile Tyr Val Ser Gly Ile Asp Thr Tyr Gly Pro Ile Ser 
225                 230                 235                 240 


Ser Val Ser Arg Ser Asp Val Asn Ile Leu Met Thr Val Asn Arg Asp 
                245                 250                 255     


Thr Lys Lys Ile Leu Leu Thr Thr Thr Pro Arg Asp Ala Tyr Val Pro 
            260                 265                 270         


Ile Ala Asp Gly Gly Asn Asn Gln Lys Asp Lys Leu Thr His Ala Gly 
        275                 280                 285             


Ile Tyr Gly Val Asp Ser Ser Ile His Thr Leu Glu Asn Leu Tyr Gly 
    290                 295                 300                 


Val Asp Ile Asn Tyr Tyr Val Arg Leu Asn Phe Thr Ser Phe Leu Lys 
305                 310                 315                 320 


Leu Ile Asp Leu Leu Gly Gly Ile Asp Val Tyr Asn Asp Gln Glu Phe 
                325                 330                 335     


Thr Ala His Thr Asn Gly Lys Tyr Tyr Pro Ala Gly Asn Val His Leu 
            340                 345                 350         


Asp Ser Glu Gln Ala Leu Gly Phe Val Arg Glu Arg Tyr Ser Leu Ala 
        355                 360                 365             


Asp Gly Asp Arg Asp Arg Gly Arg His Gln Gln Lys Val Ile Val Ala 
    370                 375                 380                 


Ile Leu Gln Lys Leu Thr Ser Thr Glu Val Leu Lys Asn Tyr Ser Thr 
385                 390                 395                 400 


Ile Ile Asn Ser Leu Gln Asp Ser Ile Gln Thr Asn Met Pro Leu Glu 
                405                 410                 415     


Thr Met Ile Asn Leu Val Asn Ala Gln Leu Glu Ser Gly Gly Asn Tyr 
            420                 425                 430         


Lys Val Asn Ser Gln Asp Leu Lys Gly Thr Gly Arg Met Asp Leu Pro 
        435                 440                 445             


Ser Tyr Ala Met Pro Asp Ser Asn Leu Tyr Val Met Glu Ile Asp Asp 
    450                 455                 460                 


Ser Ser Leu Ala Val Val Lys Ala Ala Ile Gln Asp Val Met Glu Gly 
465                 470                 475                 480 


Arg 
    


<210>  92
<211>  243
<212>  PRT
<213>  S. pneumoniae

<400>  92

Met Ile Asp Ile His Ser His Ile Val Phe Asp Val Asp Asp Gly Pro 
1               5                   10                  15      


Lys Ser Arg Glu Glu Ser Lys Ala Leu Leu Ala Glu Ser Tyr Arg Gln 
            20                  25                  30          


Gly Val Arg Thr Ile Val Ser Thr Ser His Arg Arg Lys Gly Met Phe 
        35                  40                  45              


Glu Thr Pro Glu Glu Lys Ile Ala Glu Asn Phe Leu Gln Val Arg Glu 
    50                  55                  60                  


Ile Ala Lys Glu Val Ala Ser Asp Leu Val Ile Ala Tyr Gly Ala Glu 
65                  70                  75                  80  


Ile Tyr Tyr Thr Pro Asp Val Leu Asp Lys Leu Glu Lys Lys Arg Ile 
                85                  90                  95      


Pro Thr Leu Asn Asp Ser Arg Tyr Ala Leu Ile Glu Phe Ser Met Asn 
            100                 105                 110         


Thr Pro Tyr Arg Asp Ile His Ser Ala Leu Ser Lys Ile Leu Met Leu 
        115                 120                 125             


Gly Ile Thr Pro Val Ile Ala His Ile Glu Arg Tyr Asp Ala Leu Glu 
    130                 135                 140                 


Asn Asn Glu Lys Arg Val Arg Glu Leu Ile Asp Met Gly Cys Tyr Thr 
145                 150                 155                 160 


Gln Val Asn Ser Ser His Val Leu Lys Pro Lys Leu Phe Gly Glu Arg 
                165                 170                 175     


Tyr Lys Phe Met Lys Lys Arg Ala Gln Tyr Phe Leu Glu Gln Asp Leu 
            180                 185                 190         


Val His Val Ile Ala Ser Asp Met His Asn Leu Asp Gly Arg Pro Pro 
        195                 200                 205             


His Met Ala Glu Ala Tyr Asp Leu Val Thr Gln Lys Tyr Gly Glu Ala 
    210                 215                 220                 


Lys Ala Gln Glu Leu Phe Ile Asp Asn Pro Arg Lys Ile Val Met Asp 
225                 230                 235                 240 


Gln Leu Ile 
            


<210>  93
<211>  231
<212>  PRT
<213>  S. pneumoniae

<400>  93

Met Met Lys Glu Gln Asn Thr Ile Glu Ile Asp Val Phe Gln Leu Val 
1               5                   10                  15      


Lys Ser Leu Trp Lys Arg Lys Leu Met Ile Leu Ile Val Ala Leu Val 
            20                  25                  30          


Thr Gly Ala Gly Ala Phe Ala Tyr Ser Thr Phe Ile Val Lys Pro Glu 
        35                  40                  45              


Tyr Thr Ser Thr Thr Arg Ile Tyr Val Val Asn Arg Asn Gln Gly Asp 
    50                  55                  60                  


Lys Pro Gly Leu Thr Asn Gln Asp Leu Gln Ala Gly Thr Tyr Leu Val 
65                  70                  75                  80  


Lys Asp Tyr Arg Glu Ile Ile Leu Ser Gln Asp Val Leu Glu Glu Val 
                85                  90                  95      


Val Ser Asp Leu Lys Leu Asp Leu Thr Pro Lys Gly Leu Ala Asn Lys 
            100                 105                 110         


Ile Lys Val Thr Val Pro Val Asp Thr Arg Ile Val Ser Ile Ser Val 
        115                 120                 125             


Asn Asp Arg Val Pro Glu Glu Ala Ser Arg Ile Ala Asn Ser Leu Arg 
    130                 135                 140                 


Glu Val Ala Ala Gln Lys Ile Ile Ser Ile Thr Arg Val Ser Asp Val 
145                 150                 155                 160 


Thr Thr Leu Glu Glu Ala Arg Pro Ala Ile Ser Pro Ser Ser Pro Asn 
                165                 170                 175     


Ile Lys Arg Asn Thr Leu Ile Gly Phe Leu Ala Gly Val Ile Gly Thr 
            180                 185                 190         


Ser Val Ile Val Leu His Leu Glu Leu Leu Asp Thr Arg Val Lys Arg 
        195                 200                 205             


Pro Glu Asp Ile Glu Asn Thr Leu Gln Met Thr Leu Leu Gly Val Val 
    210                 215                 220                 


Pro Asn Leu Gly Lys Leu Lys 
225                 230     


<210>  94
<211>  227
<212>  PRT
<213>  S. pneumoniae

<400>  94

Met Pro Thr Leu Glu Ile Ala Gln Lys Lys Leu Glu Phe Ile Lys Lys 
1               5                   10                  15      


Ala Glu Glu Tyr Tyr Asn Ala Leu Cys Thr Asn Ile Gln Leu Ser Gly 
            20                  25                  30          


Asp Lys Leu Lys Val Ile Ser Val Thr Ser Val Asn Pro Gly Glu Gly 
        35                  40                  45              


Lys Thr Thr Thr Ser Ile Asn Ile Ala Trp Ser Phe Ala Arg Ala Gly 
    50                  55                  60                  


Tyr Lys Thr Leu Leu Ile Asp Gly Asp Thr Arg Asn Ser Val Met Leu 
65                  70                  75                  80  


Gly Val Phe Lys Ser Arg Glu Lys Ile Thr Gly Leu Thr Glu Phe Leu 
                85                  90                  95      


Ser Gly Thr Ala Asp Leu Ser His Gly Leu Cys Asp Thr Asn Ile Glu 
            100                 105                 110         


Asn Leu Phe Val Val Gln Ser Gly Ser Val Ser Pro Asn Pro Thr Ala 
        115                 120                 125             


Leu Leu Gln Ser Lys Asn Phe Asn Asp Met Ile Glu Thr Leu Arg Lys 
    130                 135                 140                 


Tyr Phe Asp Tyr Ile Ile Ile Asp Thr Pro Pro Ile Gly Ile Val Ile 
145                 150                 155                 160 


Asp Ala Ala Ile Ile Thr Gln Lys Cys Asp Ala Ser Ile Leu Val Thr 
                165                 170                 175     


Ala Thr Gly Glu Ala Asn Lys Arg Asp Ile Gln Lys Ala Lys Gln Gln 
            180                 185                 190         


Leu Lys Gln Thr Gly Lys Leu Phe Leu Gly Val Val Leu Asn Lys Leu 
        195                 200                 205             


Asp Ile Ser Val Asn Lys Tyr Gly Val Tyr Gly Ser Tyr Gly Asn Tyr 
    210                 215                 220                 


Gly Lys Lys 
225         


<210>  95
<211>  211
<212>  PRT
<213>  S. pneumoniae

<400>  95

Met Lys Asn Gly Asn Arg Ile Tyr Ser Trp Arg Leu Phe Met Tyr Gly 
1               5                   10                  15      


Ile Ile Lys Arg Leu Gly Asp Ile Leu Leu Ser Leu Ile Gly Ile Ile 
            20                  25                  30          


Ile Leu Cys Pro Val Phe Met Ile Ile Ala Ile Ala Ile Lys Leu Asp 
        35                  40                  45              


Ser Glu Gly Pro Val Ile Phe Lys Gln Lys Arg Phe Gly Ile His Lys 
    50                  55                  60                  


Glu Tyr Phe Tyr Ile Leu Lys Phe Arg Ser Met Lys Ile Asp Ala Pro 
65                  70                  75                  80  


Lys Asn Val Ala Pro Arg Asn Leu Tyr Asn Pro Glu Gln Trp Ile Thr 
                85                  90                  95      


Lys Val Gly Ala Phe Leu Arg Lys Thr Ser Leu Asp Glu Leu Pro Gln 
            100                 105                 110         


Leu Phe Asn Ile Leu Val Gly Asn Met Ser Ile Val Gly Pro Arg Pro 
        115                 120                 125             


Ala Gly Ile Asn Glu Leu Asp Leu Ile Ala Glu Arg Asp Lys Tyr Gly 
    130                 135                 140                 


Ala Asn Asp Ile Leu Pro Gly Leu Thr Gly Trp Ala Gln Ile Asn Gly 
145                 150                 155                 160 


Arg Asp Thr Leu Ser Val Glu Met Lys Thr Glu Leu Asp Gly Tyr Tyr 
                165                 170                 175     


Val Lys His Leu Ser Leu Ile Met Asp Ile Arg Cys Ile Val Lys Thr 
            180                 185                 190         


Ile Pro Tyr Val Leu Lys Arg Lys Gly Ile Val Glu Gly Ser Gly Lys 
        195                 200                 205             


Lys Glu Ser 
    210     


<210>  96
<211>  409
<212>  PRT
<213>  S. pneumoniae

<400>  96

Met Lys Ile Leu Phe Val Cys Gln His Tyr Lys Pro Glu Pro Phe Arg 
1               5                   10                  15      


Leu Ser Asp Ile Cys Glu Asp Leu Val Arg Lys Gly His Glu Val Ser 
            20                  25                  30          


Val Leu Ala Gly Ile Pro Asn Tyr Pro Glu Gly Lys Ile Tyr Ala Asp 
        35                  40                  45              


Tyr Arg His Asn Lys Lys Arg Arg Glu Ile Ile Glu Gly Val Thr Ile 
    50                  55                  60                  


Tyr Arg Ser Tyr Thr Ile Pro Arg Lys Lys Ser Val Val Phe Arg Leu 
65                  70                  75                  80  


Leu Asn Tyr Phe Ser Phe Ala Ile Ser Ser Thr Leu Gly Val Leu Leu 
                85                  90                  95      


Gly Arg Tyr Lys Thr Lys Asp Gly Ser Asn Phe Asp Cys Val Phe Val 
            100                 105                 110         


Asn Gln Leu Ser Pro Val Met Met Ala Trp Ala Gly Met Ala Tyr Lys 
        115                 120                 125             


Lys Lys Tyr Lys Lys Pro Met Phe Leu Tyr Cys Met Asp Val Trp Pro 
    130                 135                 140                 


Asp Ser Leu Thr Val Gly Gly Val Lys Gln Asp Gly Leu Ile Phe Lys 
145                 150                 155                 160 


Leu Phe Lys Phe Ile Ser Lys Lys Val Tyr Arg Ala Ser Asp Tyr Ile 
                165                 170                 175     


Phe Val Thr Ser Pro Ser Phe Lys Asn Tyr Phe Val Lys Gln Phe Asp 
            180                 185                 190         


Ile Ser Glu Gln Lys Ile Thr Tyr Leu Pro Gln Tyr Ala Glu Asp Leu 
        195                 200                 205             


Phe Ile Pro Asp Glu Ser Ile Val Asn Lys Glu Ser Val Asp Leu Thr 
    210                 215                 220                 


Phe Ala Gly Asn Ile Gly Lys Ala Gln Asn Leu Glu Thr Ile Leu Lys 
225                 230                 235                 240 


Ala Ala Ser Leu Ile Glu Lys Asn Thr Asn Leu Pro Lys Lys Ile His 
                245                 250                 255     


Phe His Phe Val Gly Asp Gly Thr Glu Leu Leu Ser Met Lys Ala Leu 
            260                 265                 270         


Ala His Glu Leu Glu Leu Lys Asn Ile Ser Phe Tyr Gly Arg Arg Ser 
        275                 280                 285             


Leu Glu Glu Met Pro Ser Phe Tyr Lys Lys Ser Asp Ala Met Leu Val 
    290                 295                 300                 


Ser Leu Ile Gly Asp Ser Ile Val Ser Arg Thr Ile Pro Gly Lys Val 
305                 310                 315                 320 


Gln Ser Tyr Met Ala Ala Gly Lys Pro Ile Ile Gly Ala Ile Ser Gly 
                325                 330                 335     


Asp Ala Lys Ile Ile Val Glu Glu Ala Asn Cys Gly Tyr Val Ser Pro 
            340                 345                 350         


Glu Arg Asp Val Lys Gln Leu Ala Lys Asn Ile Cys Lys Phe Ser Met 
        355                 360                 365             


Leu Ser Ile Lys Arg Gln Arg Glu Leu Gly Lys Lys Ala Arg Cys Tyr 
    370                 375                 380                 


Tyr Glu Asn His Phe Ser Lys Glu Gln Phe Met Leu Glu Leu Glu Thr 
385                 390                 395                 400 


Cys Leu Glu Arg Glu Ser Lys Lys Glu 
                405                 


<210>  97
<211>  358
<212>  PRT
<213>  S. pneumoniae

<400>  97

Met Arg Val Leu Phe Ile Leu Ser Asp Asn Ile Tyr Leu Thr Pro Tyr 
1               5                   10                  15      


Phe Asn Phe Tyr Lys Glu Leu Leu Lys Lys Leu Ser Ile Ser Tyr Asp 
            20                  25                  30          


Val Ile Tyr Trp Asp Lys Asn Ile Asn Glu Ile Ile Thr Lys Gln Asn 
        35                  40                  45              


Tyr Tyr Arg Ile Ser Phe Ser Gly Lys Gly Lys Leu Ser Lys Ile Leu 
    50                  55                  60                  


Gly Tyr Val Lys Phe Arg Lys Glu Ile Lys Lys Lys Leu Lys Glu Asn 
65                  70                  75                  80  


Asp Tyr Asp Met Ile Leu Pro Leu His Ser Ile Val Ser Phe Ile Leu 
                85                  90                  95      


Val Asp Phe Leu Leu Phe Ser Phe Lys Asn Arg Tyr Ile Tyr Asp Ile 
            100                 105                 110         


Arg Asp Tyr Ser Tyr Glu Lys Phe Leu Val Tyr Arg Leu Val Gln Lys 
        115                 120                 125             


Gln Leu Val Lys Asn Ser Leu Met Asn Ile Val Ser Ser Asp Gly Tyr 
    130                 135                 140                 


Lys Phe Phe Leu Pro Met Gly Glu Tyr Phe Thr Thr His Asn Leu Pro 
145                 150                 155                 160 


Asn Met Ile Glu Leu Asn Glu Val Lys Gln Leu Lys Asn Asn Ser Thr 
                165                 170                 175     


Phe Pro Ile Gln Leu Ser Tyr Ile Gly Leu Ile Arg Phe Gln Glu Gln 
            180                 185                 190         


Asn Lys Lys Ile Ile Asp Phe Phe Ala Asn Asp Ser Arg Phe Gln Leu 
        195                 200                 205             


Asn Phe Ile Gly Thr Asn Ala Gly Glu Leu Arg Glu Phe Cys Gln Glu 
    210                 215                 220                 


Lys Asn Ile Ser Asn Val Asn Leu Val Asp Thr Phe Gln Pro Lys Asp 
225                 230                 235                 240 


Thr Met Ser Phe Tyr Lys Asn Thr Asp Ala Val Leu Asn Leu Tyr Gly 
                245                 250                 255     


Asn His Thr Pro Leu Leu Asp Tyr Ala Leu Ser Asn Lys Leu Tyr Phe 
            260                 265                 270         


Ala Ala Leu Leu Tyr Lys Pro Ile Leu Val Cys Glu Asp Thr Tyr Met 
        275                 280                 285             


Glu Lys Val Ser Ile Glu Asn Gly Phe Gly Phe Val Leu Pro Met Lys 
    290                 295                 300                 


Asp Glu Ser Glu Lys Asp Cys Leu Ala Leu Tyr Ile Gln Asn Leu Asp 
305                 310                 315                 320 


Arg Lys Gln Leu Ile Lys Asn Cys Asp Asn Phe Met Asp Arg Ile Ser 
                325                 330                 335     


Leu Glu Lys Gln Lys Thr Glu Ile Glu Leu Glu Lys Arg Ile Leu Ser 
            340                 345                 350         


Leu Arg Lys Lys Asn Asp 
        355             


<210>  98
<211>  372
<212>  PRT
<213>  S. pneumoniae

<400>  98

Met Ile Lys Val Leu His Leu Phe Thr Thr Leu Asp Ser Gly Gly Val 
1               5                   10                  15      


Glu Ser Phe Leu Phe Asn Tyr Tyr Ser His Ile Asp Arg Lys Lys Ile 
            20                  25                  30          


Gln Phe Asp Phe Ile Val Pro Gly Lys Glu Gln Gly Phe Leu Glu Asp 
        35                  40                  45              


Lys Met Lys Glu Leu Gly Ala Lys Val Tyr His Val Pro Leu Leu Arg 
    50                  55                  60                  


Lys Lys Pro Leu His Gln Phe Leu Ser Leu Ala Arg Ile Ile Lys Lys 
65                  70                  75                  80  


Gly Asp Tyr Asp Ile Val His Cys His Gly Tyr Lys Ser Ala Ile Gly 
                85                  90                  95      


Leu Ile Leu Ser Lys Ile Ile Gly Cys Lys Ile Arg Ile Ile His Ser 
            100                 105                 110         


His Met Ala Tyr Val Thr Glu Asn Ser Phe Gln Lys Val Leu Arg Lys 
        115                 120                 125             


Leu Val Thr Ile Leu Val Lys Ile Leu Ala Thr His Trp Phe Ala Cys 
    130                 135                 140                 


Gly Glu Asp Ser Ala Lys Trp Leu Tyr Gly Glu Lys Ala Tyr Lys Asp 
145                 150                 155                 160 


Gly Lys Ile Glu Ile Ile Phe Asn Ala Ile Asp Leu Lys Lys Tyr Gln 
                165                 170                 175     


Phe Leu Ser Asp Val Arg Glu Lys Cys Arg Arg Glu Leu Asp Val Ser 
            180                 185                 190         


Asn Lys Phe Val Leu Gly Asn Ile Ala Arg Leu Ser Asp Gln Lys Asn 
        195                 200                 205             


Gln Ser Tyr Leu Phe Asn Val Leu Lys Glu Leu Ile Leu Ile Lys Pro 
    210                 215                 220                 


Asn Val Ile Leu Leu Leu Val Gly Asn Gly Glu Asp Glu Gln Lys Leu 
225                 230                 235                 240 


Lys Gln Lys Ala Leu Glu Leu Asn Leu Thr Pro Tyr Val Leu Phe Leu 
                245                 250                 255     


Gly Arg Arg Thr Asp Ile Ser Asp Leu Leu Ser Ala Met Asp Val Phe 
            260                 265                 270         


Leu Leu Pro Ser Lys Tyr Glu Gly Leu Pro Val Ser Leu Val Glu Ala 
        275                 280                 285             


Gln Ala Ser Gly Leu Gln Ile Leu Ser Ser Asp Thr Val Thr Gln Glu 
    290                 295                 300                 


Val Asp Val Thr Lys Asn Ile Ser Tyr Leu Pro Ile Asn Glu Glu Ser 
305                 310                 315                 320 


Val Leu Leu Trp Lys Asp Lys Val Leu Ser Leu Thr Ser Glu Glu Cys 
                325                 330                 335     


Asn Arg Phe Glu Ile Asn Asn Ser Met Thr Asp Gly Leu Tyr Asp Ile 
            340                 345                 350         


Cys Tyr Gln Ala Ser Lys Leu Leu Asn Arg Tyr Gln Glu Met Cys Val 
        355                 360                 365             


Ile Lys Glu Ile 
    370         


<210>  99
<211>  466
<212>  PRT
<213>  S. pneumoniae

<400>  99

Met Gln Thr Lys Tyr Ile Cys Arg Val Thr Leu Val Thr Leu Ser Phe 
1               5                   10                  15      


Ile Phe Ala Phe Cys Tyr Leu Phe Trp Thr Leu Asp Asn Trp Asn Asn 
            20                  25                  30          


Gly Phe Leu Ile Ser Asn Tyr Val Pro Ser Ile Phe Ile Trp Val Cys 
        35                  40                  45              


Phe Leu Ile Ile Phe Gln Ile Thr Gly Phe Ile Leu Gln Lys Val Ser 
    50                  55                  60                  


Ile Tyr Asp Phe Ser Val Trp Tyr Leu Ile Leu Ser Tyr Phe Phe Met 
65                  70                  75                  80  


Phe Gly Leu Ile Phe Asn Glu Tyr Met Gly Phe Gln Thr Thr Leu Leu 
                85                  90                  95      


Trp Ser Pro Ser Asn Phe Tyr Asn Asn Glu Glu Leu Phe His Ser Tyr 
            100                 105                 110         


Ile Phe Ile Ile Trp Ile Leu Phe Cys Tyr Ser Val Gly Tyr Leu Phe 
        115                 120                 125             


Phe Tyr Ser Asp Gly Lys Val His Tyr His Ser Glu Val Gln Asn Tyr 
    130                 135                 140                 


Gln Glu Asn Glu Glu Lys Ile Leu Tyr Asn Ala Gly Arg Ile Leu Thr 
145                 150                 155                 160 


Gly Val Gly Phe Ile Ser Arg Val Ile Thr Asp Ser Lys Thr Val Leu 
                165                 170                 175     


Ala Val Arg Ala Ala Asn Ser Tyr Ser Ala Tyr Ser Glu Ala Ala Ser 
            180                 185                 190         


Ser Gly Ile Ile Asp Asp Leu Gly Val Leu Met Leu Pro Gly Val Phe 
        195                 200                 205             


Ser Leu Phe Tyr Ser Asp Lys Leu Ser Arg Val Ile Lys Arg Thr Ile 
    210                 215                 220                 


Phe Trp Val Met Leu Phe Tyr Leu Ile Leu Ile Met Ile Leu Thr Gly 
225                 230                 235                 240 


Ser Arg Lys Ile Gln Val Phe Ser Ile Leu Ala Leu Val Leu Val Tyr 
                245                 250                 255     


Thr Gln Ser Leu Gly Ile Thr Phe Ser Lys Lys Arg Val Leu Val Phe 
            260                 265                 270         


Leu Ile Val Thr Val Phe Leu Leu Asn Val Leu Val Val Ile Arg Gly 
        275                 280                 285             


His Arg Phe Asp Leu Asn Thr Ile Gly Ile Tyr Leu Phe Asp Ser Phe 
    290                 295                 300                 


Ser Ser Leu Asp Phe Val Lys Asn Ile Leu Gly Glu Val Phe Ser Glu 
305                 310                 315                 320 


Ser Gly Leu Thr Ser Leu Thr Val Ala Ser Ala Val Thr Val Val Pro 
                325                 330                 335     


Ser Ser Ile Pro Tyr Glu Tyr Gly Met Thr Phe Leu Arg Thr Ile Leu 
            340                 345                 350         


Ser Ile Phe Pro Ile Gly Trp Leu Val Gly Asp Phe Phe Asp Lys Ala 
        355                 360                 365             


Ser Ala Thr Val Val Ile Asn Lys Phe Leu Gly Leu Pro Val Gly Ser 
    370                 375                 380                 


Ser Phe Val Glu Glu Leu Phe Trp Asn Phe Gly Tyr Tyr Gly Gly Val 
385                 390                 395                 400 


Phe Trp Ser Phe Val Leu Gly Ile Phe Ser Gly Trp Arg Leu Asn Phe 
                405                 410                 415     


Arg Ala Phe Gln Thr Ser Lys Ile Ser Lys Val Ile Tyr Phe Ser Val 
            420                 425                 430         


Ile Ser Gln Leu Leu Leu Leu Val Arg Ser Ser Ser Ile Asp Val Tyr 
        435                 440                 445             


Arg Pro Ile Met Tyr Ser Leu Ile Met Ile Phe Ile Phe Arg Arg Leu 
    450                 455                 460                 


Lys Lys 
465     


<210>  100
<211>  360
<212>  PRT
<213>  S. pneumoniae

<400>  100

Met Val Lys Lys Ile Met Leu His Gly Ala Thr Asp Tyr Gly Ser Ser 
1               5                   10                  15      


Asn Tyr Gly Asp Tyr Leu Tyr Gly Glu Ile Val Tyr Asp Leu Leu Glu 
            20                  25                  30          


Ser Lys Gly Tyr Glu Val Ser Phe Tyr Asn Pro Ser Asp Phe Phe Gln 
        35                  40                  45              


Met Tyr Leu Lys Glu Tyr Arg Gln Lys Gln Ser Phe Thr Lys Lys Gln 
    50                  55                  60                  


Ala Asp Ala Ile Leu Tyr Ile Pro Gly Gly Tyr Phe Gly Glu Gly His 
65                  70                  75                  80  


Asn Ala Arg Phe Arg Asp Asn Leu Ile Gln Phe Lys Arg Phe Leu Pro 
                85                  90                  95      


Leu Gly Ile Trp Ala Ser Tyr Phe Lys Lys Pro Ile Gly Val Leu Gly 
            100                 105                 110         


Ile Gly Ala Gly Pro Asn Asn Asp Ser Leu Met Asn Tyr Gly Ile Lys 
        115                 120                 125             


Arg Ile Ile Asn His Ala Gln Phe Ile Thr Val Arg Asp Arg Glu Ser 
    130                 135                 140                 


Phe Asp Ser Leu Lys His Leu Ser Pro Ser Ala Pro Val His Glu Thr 
145                 150                 155                 160 


Phe Asp Leu Ile Ile Ser Ser Lys Leu Arg Glu Glu Lys Thr Glu Gln 
                165                 170                 175     


Leu Cys Gln Leu Lys Arg Glu Ala Lys Asp Lys Lys Ile Ile Leu Val 
            180                 185                 190         


His Tyr Asn His Ser Lys Lys Ala Leu Glu Lys Phe Ala Glu Ser Ile 
        195                 200                 205             


Ser Leu Phe Leu Glu Asn Asn Pro Asn Tyr Tyr Val Val Val Thr Ser 
    210                 215                 220                 


Asp Ser Ile Leu Pro Tyr Glu Asp Ala Tyr Tyr Gln Glu Phe Arg Lys 
225                 230                 235                 240 


Leu Val Arg Thr Glu Asp Cys Phe Gln Phe Lys Tyr His Ser Pro Ala 
                245                 250                 255     


Glu Met Thr Ser Leu Leu Lys Met Val Asp Val Val Leu Thr Cys Lys 
            260                 265                 270         


Leu His Val Gly Val Val Ala Thr Cys Phe Asn Lys Ser Val Ile Ala 
        275                 280                 285             


Ile Ala Cys His Pro Glu Lys Thr Ala Arg Tyr Tyr Gly Ala Ile Gly 
    290                 295                 300                 


Glu Leu Gln Arg Cys Glu Ser Leu Phe Asp Ser Ser Val Asn Ser Ile 
305                 310                 315                 320 


Val Lys Lys Leu Glu Thr Phe His Leu Lys Pro Ile Thr Ile Pro Ser 
                325                 330                 335     


Glu Leu Val Leu Lys Ala Arg Ser Ser Leu Asp Tyr Leu Asp Leu Phe 
            340                 345                 350         


Leu Glu Gly Leu Val Arg Glu Ser 
        355                 360 


<210>  101
<211>  413
<212>  PRT
<213>  S. pneumoniae

<400>  101

Met Lys Val Asp Arg Ile Ser Phe Ile Lys Asn Thr Ser Ser Leu Tyr 
1               5                   10                  15      


Ile Leu Asn Ile Val Lys Leu Leu Phe Pro Leu Leu Thr Leu Pro Tyr 
            20                  25                  30          


Leu Thr Arg Val Leu Ser Leu Asp Ala Tyr Gly Met Val Ile Tyr Val 
        35                  40                  45              


Lys Ala Leu Ile Ala Tyr Val Gln Leu Val Ile Asp Phe Gly Phe Met 
    50                  55                  60                  


Ile Ser Ala Thr Lys Asn Ile Val Asn Ala Cys Thr Thr Pro Ser Lys 
65                  70                  75                  80  


Ile Gly Arg Ile Val Gly Asp Thr Leu Val Glu Lys Ile Phe Leu Ser 
                85                  90                  95      


Ile Ile Ser Ile Leu Ile Tyr Thr Ile Leu Met Trp Gln Ile Pro Ile 
            100                 105                 110         


Met Arg Glu Asn Ile Leu Phe Ser Val Phe Tyr Leu Leu Ala Thr Val 
        115                 120                 125             


Thr Asn Ile Phe Ile Phe Asp Phe Leu Phe Arg Gly Ile Glu Lys Met 
    130                 135                 140                 


His Ala Val Ala Ile Pro Tyr Ile Ile Ser Lys Thr Ile Ile Thr Ile 
145                 150                 155                 160 


Leu Thr Phe Ile Val Val Lys Asp Asp Ser Ser Ile Leu Trp Ile Pro 
                165                 170                 175     


Ile Leu Glu Gly Ile Gly Asn Leu Val Ala Ala Val Val Ser Tyr Arg 
            180                 185                 190         


Phe Leu His Tyr Tyr Gly Ile Lys Leu Ser Phe Ser Tyr Leu Ser Val 
        195                 200                 205             


Trp Val Lys Asp Leu Lys Glu Ser Ser Ile Tyr Phe Leu Ser Asn Phe 
    210                 215                 220                 


Ala Thr Thr Ile Phe Gly Val Phe Thr Thr Val Ile Ser Gly Phe Tyr 
225                 230                 235                 240 


Leu Gln Ser Gln Glu Ile Ala Phe Trp Gly Ile Ala Met Gln Leu Leu 
                245                 250                 255     


Ser Ala Ala Lys Ser Leu Tyr Asn Pro Ile Ala Asn Ser Leu Tyr Pro 
            260                 265                 270         


His Met Ile Arg Thr Lys Asp Ile Gln Ser Val Lys Ser Ile Asn Arg 
        275                 280                 285             


Ile Met Phe Ile Pro Ile Ile Phe Gly Val Leu Ile Val Leu Phe Phe 
    290                 295                 300                 


Ser Asn Gln Ile Leu Ser Ile Ile Gly Gly Glu Lys Tyr Thr Val Ser 
305                 310                 315                 320 


Ala Asp Phe Leu Lys Tyr Leu Leu Pro Ala Phe Val Ala Ser Phe Tyr 
                325                 330                 335     


Ser Met Ile Tyr Gly Trp Pro Val Leu Gly Ala Ile Asp Lys Val Lys 
            340                 345                 350         


Glu Thr Thr Met Thr Thr Ile Leu Ala Ser Ile Val Gln Thr Leu Gly 
        355                 360                 365             


Leu Gly Ile Phe Ile Leu Ser Asp Asn Phe Ser Leu Val Thr Leu Ala 
    370                 375                 380                 


Ile Cys Ser Ser Met Ser Glu Val Val Leu Trp Ile Ser Arg Tyr Leu 
385                 390                 395                 400 


Ile Tyr Phe Lys Asn Arg Ser Leu Phe Val Arg Ser Lys 
                405                 410             


<210>  102
<211>  365
<212>  PRT
<213>  S. pneumoniae

<400>  102

Met Lys Lys Val Val Val Val Phe Gly Thr Arg Pro Glu Ala Ile Lys 
1               5                   10                  15      


Met Cys Pro Leu Val Lys Glu Leu Arg Thr Arg Lys Asn Ile Glu Thr 
            20                  25                  30          


Leu Val Cys Val Thr Gly Gln His Arg Gln Met Leu Asp Gln Val Leu 
        35                  40                  45              


Asp Thr Phe Gly Ile Ile Pro Asp Phe Asp Leu Ser Ile Met Lys Asp 
    50                  55                  60                  


Lys Gln Thr Leu Phe Asp Val Thr Ile Gly Ile Leu Glu Gly Met Lys 
65                  70                  75                  80  


Ala Ile Leu Glu Ser Glu Lys Pro Asp Leu Val Leu Val His Gly Asp 
                85                  90                  95      


Thr Ser Thr Thr Phe Ala Ser Ser Leu Ala Ala Phe Tyr Leu Gln Ile 
            100                 105                 110         


Pro Ile Gly His Val Glu Ala Gly Leu Arg Thr Tyr Asp Ile Tyr Ser 
        115                 120                 125             


Pro Tyr Pro Glu Glu Phe Asn Arg Gln Ala Val Gly Val Leu Ala Gln 
    130                 135                 140                 


Tyr His Phe Thr Pro Thr Gln Leu Ser Lys Asp Asn Leu Leu Arg Glu 
145                 150                 155                 160 


Gly Lys Thr Pro Glu Ser Ile Phe Val Thr Gly Asn Thr Ala Ile Asp 
                165                 170                 175     


Ala Leu Gln Thr Thr Ile Gln Glu Asp Tyr Thr His Pro Glu Leu Glu 
            180                 185                 190         


Trp Ile Gly Glu Ser Arg Phe Ile Leu Ile Thr Ala His Arg Arg Glu 
        195                 200                 205             


Asn Leu Gly Glu Pro Met Arg His Met Phe Arg Ala Ile Arg Arg Ile 
    210                 215                 220                 


Ile Glu Glu Tyr Ser Asp Val Lys Ala Ile Tyr Pro Ile His Met Asn 
225                 230                 235                 240 


Pro Arg Val Arg Gln Ile Ala Glu Glu Glu Leu Ser Gly Cys Glu Arg 
                245                 250                 255     


Ile Lys Met Ile Glu Pro Leu Glu Val Leu Asp Phe His Asn Phe Leu 
            260                 265                 270         


Ser Arg Ser Tyr Leu Ile Leu Thr Asp Ser Gly Gly Ile Gln Glu Glu 
        275                 280                 285             


Ala Pro Ser Leu Gly Lys Pro Val Leu Val Met Arg Asp Thr Thr Glu 
    290                 295                 300                 


Arg Pro Glu Gly Ile Glu Ala Gly Thr Leu Lys Leu Val Gly Ala Asp 
305                 310                 315                 320 


Glu Asn Asn Ile Tyr Arg His Phe Lys Glu Leu Leu Glu Asn Asp Ser 
                325                 330                 335     


Val Tyr Gln Ala Met Ser Gln Ala Ser Asn Pro Tyr Gly Asp Gly Thr 
            340                 345                 350         


Ala Cys Lys Lys Ile Ala Asp Ile Leu Glu Gly Glu Val 
        355                 360                 365 


<210>  103
<211>  351
<212>  PRT
<213>  S. pneumoniae

<400>  103

Met Ser Gln Phe Thr Gly Lys Thr Leu Leu Ile Thr Gly Gly Thr Gly 
1               5                   10                  15      


Ser Phe Gly Asn Ala Val Leu Lys Arg Phe Leu Glu Thr Asp Val Ser 
            20                  25                  30          


Glu Ile Arg Ile Phe Ser Arg Asp Glu Lys Lys Gln Asp Asp Met Arg 
        35                  40                  45              


His Glu Phe Gln Val Lys Val Pro Glu Val Ala Gly Lys Ile Arg Phe 
    50                  55                  60                  


Tyr Leu Gly Asp Val Arg Asp Leu Ala Ser Val Lys Asn Ala Met His 
65                  70                  75                  80  


Gly Val Asp Tyr Val Phe His Ala Ala Ala Leu Lys Gln Val Pro Ser 
                85                  90                  95      


Cys Glu Phe Phe Pro Val Glu Ala Val Lys Thr Asn Ile Leu Gly Thr 
            100                 105                 110         


Glu Asn Val Leu Thr Ala Ala Ile Glu Ala Gly Val Lys Gln Val Ile 
        115                 120                 125             


Cys Leu Ser Thr Asp Lys Ala Ala Tyr Pro Val Asn Ala Met Gly Thr 
    130                 135                 140                 


Ser Lys Ala Met Met Glu Lys Ile Ala Val Ala Lys Ser Arg Thr Val 
145                 150                 155                 160 


Asn Pro Glu His Thr Lys Ile Cys Val Thr Arg Tyr Gly Asn Val Leu 
                165                 170                 175     


Cys Ser Arg Gly Ser Val Val Pro Leu Trp Ile Glu Gln Ile Lys Gln 
            180                 185                 190         


Gly Asn Ala Leu Thr Ile Thr Glu Pro Ser Met Thr Arg Phe Val Met 
        195                 200                 205             


Thr Leu Glu Glu Ala Val Asp Leu Val Leu Phe Ala Phe Glu Glu Gly 
    210                 215                 220                 


Lys Ser Gly Asp Ile Leu Val Gln Lys Ala Pro Ala Cys Thr Ile Glu 
225                 230                 235                 240 


Val Leu Ala Lys Ala Val Ser Glu Ile Phe Ala Ser Glu Gln Asp Ile 
                245                 250                 255     


Lys Ile Ile Gly Ile Arg His Gly Glu Lys Arg Tyr Glu Thr Leu Leu 
            260                 265                 270         


Thr Asn Glu Glu Cys Ala Asn Ala Ile Asp Leu Gly Asp Phe Tyr Arg 
        275                 280                 285             


Val Pro Ser Asp Asn Arg Asn Leu Asn Tyr Asp Lys Tyr Phe Lys Asp 
    290                 295                 300                 


Gly Ser Thr Asn Arg Asn Leu Leu Thr Glu Phe Asn Ser Asn Asn Thr 
305                 310                 315                 320 


Asp Leu Met Asp Val Glu Gln Val Lys Arg Lys Leu Leu Glu Leu Asp 
                325                 330                 335     


Glu Ile Gln Thr Ala Ile Arg Asp Met Val Ala Asp Glu Glu Met 
            340                 345                 350     


<210>  104
<211>  409
<212>  PRT
<213>  S. pneumoniae

<400>  104

Met Ile Lys Asn Ile Leu Ile Thr Gly Ala Lys Gly Phe Val Gly Lys 
1               5                   10                  15      


Asn Leu Ile Cys Thr Leu Glu Ala Leu Lys Asp Gly Arg Asp Arg Thr 
            20                  25                  30          


Arg Pro Asn Leu Glu Ile Gly Glu Ile Phe Gln Tyr Asp Arg Asp Thr 
        35                  40                  45              


Asp Pro Ile Leu Leu Asp Glu Tyr Cys Lys Lys Ala Asp Phe Val Phe 
    50                  55                  60                  


His Leu Ala Gly Val Asn Arg Pro Gln Asn Pro Asp Glu Phe Met Glu 
65                  70                  75                  80  


Gly Asn Tyr Gly Phe Ser Ser Arg Leu Leu Glu Ile Leu Glu Lys Tyr 
                85                  90                  95      


Glu Asn Thr Cys Pro Val Leu Leu Ser Ser Ser Thr Gln Ala Ser Leu 
            100                 105                 110         


Glu Gly Arg Phe Ser Asn Ser Ile Tyr Gly Gln Ser Lys Leu Ala Gly 
        115                 120                 125             


Glu Glu Leu Phe Phe Glu Tyr Gly Lys Lys Thr Gly Ala Pro Val Leu 
    130                 135                 140                 


Val Tyr Arg Phe Pro Asn Leu Tyr Gly Lys Trp Cys Arg Pro Asn Tyr 
145                 150                 155                 160 


Asn Ser Ala Val Ala Thr Phe Cys Tyr Asn Leu Ala His Asp Leu Pro 
                165                 170                 175     


Ile Gln Val Asn Asp Pro Ser Val Glu Leu Glu Leu Leu Tyr Ile Asp 
            180                 185                 190         


Asp Leu Ile Gln Glu Cys Leu Thr Ala Leu Glu Gly Asn Pro His Arg 
        195                 200                 205             


Cys Asn Leu Asp Gly Leu Gln Ile Leu Pro Ser Pro Ser Gly Asn Tyr 
    210                 215                 220                 


Cys Tyr Val Pro Thr Thr His Arg Ala Thr Leu Gly Glu Ile Val Ser 
225                 230                 235                 240 


Leu Leu Glu Thr Phe Lys Lys Gln Pro Asp Ser Leu Val Met Pro Glu 
                245                 250                 255     


Ile Pro Gln Gly Ser Phe Lys Lys Lys Leu Tyr Ser Thr Tyr Leu Ser 
            260                 265                 270         


Tyr Leu Pro Val Asp Lys Phe Lys Phe Pro Leu Lys Met Asn Ile Asp 
        275                 280                 285             


Glu Arg Gly Ser Phe Thr Glu Leu Leu Lys Thr Glu Asn Thr Gly Gln 
    290                 295                 300                 


Phe Ser Val Asn Ile Ser Lys Pro Gly Ile Thr Lys Gly Gln His Trp 
305                 310                 315                 320 


His His Ser Lys Trp Glu Phe Phe Met Val Val Ser Gly Arg Ala Leu 
                325                 330                 335     


Ile Gln Glu Arg Arg Ile Gly Leu Asp Glu Asn Gly Gln Glu Tyr Pro 
            340                 345                 350         


Ile Leu Asn Phe Glu Val Ser Gly Asp Lys Ile Glu Ala Ile His Met 
        355                 360                 365             


Ile Pro Gly Tyr Ala His Asn Ile Ile Asn Leu Ser Asp Thr Glu Asn 
    370                 375                 380                 


Leu Ile Thr Val Met Trp Ala Asn Glu Ser Phe Asp Pro Arg His Pro 
385                 390                 395                 400 


Asp Thr Phe Phe Glu Gln Val Glu Lys 
                405                 


<210>  105
<211>  394
<212>  PRT
<213>  S. pneumoniae

<400>  105

Met Lys Ile Lys Thr Asp Tyr Ser Asp Ile His Phe Lys Asp Asn Gly 
1               5                   10                  15      


Lys Leu Lys Leu Leu Ile Ile Val Gly Thr Arg Pro Glu Ile Ile Arg 
            20                  25                  30          


Leu Ser Ser Val Ile Thr Lys Cys Arg Lys Tyr Phe Asp Val Ile Leu 
        35                  40                  45              


Ala His Thr Gly Gln Asn Tyr Asp Tyr Asn Leu Asn Gly Ile Phe Phe 
    50                  55                  60                  


Asp Asn Leu Gly Leu Asp Thr Pro Asp Val Tyr Met Asp Ala Val Gly 
65                  70                  75                  80  


Asp Asp Leu Gly Ala Thr Val Gly Asn Ile Ile Asn Thr Ser Tyr Lys 
                85                  90                  95      


Leu Met Asn Gln Ile Lys Pro Asp Ala Leu Leu Ile Leu Gly Asp Thr 
            100                 105                 110         


Asn Ser Cys Leu Ser Ala Ile Ala Ala Lys Arg Leu His Ile Pro Ile 
        115                 120                 125             


Phe His Met Glu Ala Gly Asn Arg Cys Lys Asp Glu Cys Leu Pro Glu 
    130                 135                 140                 


Glu Thr Asn Arg Arg Ile Val Asp Val Ile Ser Asp Val Asn Leu Ala 
145                 150                 155                 160 


Tyr Ser Glu His Ala Arg Lys Tyr Leu His Glu Cys Gly Leu Pro Lys 
                165                 170                 175     


Glu Arg Thr Tyr Val Thr Gly Ser Pro Met Ala Glu Val Leu His Lys 
            180                 185                 190         


Asn Leu Ser Ala Ile Glu Ser Ser Asp Ile His Glu Arg Leu Gly Leu 
        195                 200                 205             


Lys Lys Gly Gly Tyr Ile Leu Leu Ser Ala His Arg Glu Glu Asn Ile 
    210                 215                 220                 


Asp Thr Asp Lys Asn Phe Ile Ser Leu Phe Thr Ala Ile Asn Gln Leu 
225                 230                 235                 240 


Ala Glu Lys Tyr Asn Met Pro Ile Leu Tyr Ser Cys His Pro Arg Ser 
                245                 250                 255     


Lys Lys Arg Leu Gln Glu Ser Gly Phe Lys Leu Asp Lys Arg Val Ile 
            260                 265                 270         


Gln His Glu Pro Leu Gly Phe His Asp Tyr Asn Cys Leu Gln Met Asn 
        275                 280                 285             


Ala Phe Val Val Val Ser Asp Ser Gly Thr Leu Pro Glu Glu Ser Ser 
    290                 295                 300                 


Phe Phe Thr Ser Gln Gly Tyr Pro Phe Pro Ala Val Cys Ile Arg Thr 
305                 310                 315                 320 


Ser Thr Glu Arg Pro Glu Ser Leu Asp Lys Ala Gly Phe Ile Leu Ala 
                325                 330                 335     


Gly Ile Asp Glu Asn Ser Leu Leu Gln Ala Val Glu Thr Ala Val Ser 
            340                 345                 350         


Leu Ala Gln Asp Glu Asp Phe Gly Leu Pro Val Pro Asp Tyr Val Glu 
        355                 360                 365             


Glu Asn Val Ser Thr Lys Val Val Lys Ile Ile Gln Ser Tyr Thr Gly 
    370                 375                 380                 


Ile Val Asp Lys Ile Val Trp Arg Lys Ser 
385                 390                 


<210>  106
<211>  484
<212>  PRT
<213>  S. pneumoniae

<400>  106

Met Leu Ile Met Ser Arg Arg Phe Lys Lys Ser Arg Ser Gln Lys Val 
1               5                   10                  15      


Lys Arg Ser Val Asn Ile Val Leu Leu Thr Ile Tyr Leu Leu Leu Val 
            20                  25                  30          


Cys Phe Leu Leu Phe Leu Ile Phe Lys Tyr Asn Ile Leu Ala Phe Arg 
        35                  40                  45              


Tyr Leu Asn Leu Val Val Thr Ala Leu Val Leu Leu Val Ala Leu Val 
    50                  55                  60                  


Gly Leu Leu Leu Ile Ile Tyr Lys Lys Ala Glu Lys Phe Thr Ile Phe 
65                  70                  75                  80  


Leu Leu Val Phe Ser Ile Leu Val Ser Ser Val Ser Leu Phe Ala Val 
                85                  90                  95      


Gln Gln Phe Val Gly Leu Thr Asn Arg Leu Asn Ala Thr Ser Asn Tyr 
            100                 105                 110         


Ser Glu Tyr Ser Ile Ser Val Ala Val Leu Ala Asp Ser Asp Ile Glu 
        115                 120                 125             


Asn Val Thr Gln Leu Thr Ser Val Thr Ala Pro Thr Gly Thr Asp Asn 
    130                 135                 140                 


Glu Asn Ile Gln Lys Leu Leu Ala Asp Ile Lys Ser Ser Gln Asn Thr 
145                 150                 155                 160 


Asp Leu Thr Val Asp Gln Ser Ser Ser Tyr Leu Ala Ala Tyr Lys Ser 
                165                 170                 175     


Leu Ile Ala Gly Glu Thr Lys Ala Ile Val Leu Asn Ser Val Phe Glu 
            180                 185                 190         


Asn Ile Ile Glu Ser Glu Tyr Pro Asp Tyr Ala Ser Lys Ile Lys Lys 
        195                 200                 205             


Ile Tyr Thr Lys Gly Phe Thr Lys Lys Val Glu Ala Pro Lys Thr Ser 
    210                 215                 220                 


Lys Asn Gln Ser Phe Asn Ile Tyr Val Ser Gly Ile Asp Thr Tyr Gly 
225                 230                 235                 240 


Pro Ile Ser Ser Val Ser Arg Ser Asp Val Asn Ile Leu Met Thr Val 
                245                 250                 255     


Asn Arg Asp Thr Lys Lys Ile Leu Leu Thr Thr Thr Pro Arg Asp Ala 
            260                 265                 270         


Tyr Val Pro Ile Ala Asp Gly Gly Asn Asn Gln Lys Asp Lys Leu Thr 
        275                 280                 285             


His Ala Gly Ile Tyr Gly Val Asp Ser Ser Ile His Thr Leu Glu Asn 
    290                 295                 300                 


Leu Tyr Gly Val Asp Ile Asn Tyr Tyr Val Arg Leu Asn Phe Thr Ser 
305                 310                 315                 320 


Phe Leu Lys Met Ile Asp Leu Leu Gly Gly Val Asp Val His Asn Asp 
                325                 330                 335     


Gln Glu Phe Ser Ala Leu His Gly Lys Phe His Phe Pro Val Gly Asn 
            340                 345                 350         


Val His Leu Asp Ser Glu Gln Ala Leu Gly Phe Val Arg Glu Arg Tyr 
        355                 360                 365             


Ser Leu Ala Asp Gly Asp Arg Asp Arg Gly Arg Asn Gln Gln Lys Val 
    370                 375                 380                 


Ile Val Ala Ile Leu Gln Lys Leu Thr Ser Thr Glu Ala Leu Lys Asn 
385                 390                 395                 400 


Tyr Ser Thr Ile Ile Asn Ser Leu Gln Asp Ser Ile Gln Thr Asn Met 
                405                 410                 415     


Pro Leu Glu Thr Met Ile Asn Leu Val Asn Ala Gln Leu Glu Ser Gly 
            420                 425                 430         


Gly Asn Tyr Lys Val Asn Ser Gln Asp Leu Lys Gly Thr Gly Arg Thr 
        435                 440                 445             


Asp Leu Pro Ser Tyr Ala Met Pro Asp Ser Asn Leu Tyr Val Leu Glu 
    450                 455                 460                 


Ile Asp Asp Ser Ser Leu Ala Val Val Lys Ala Ala Ile Gln Asp Val 
465                 470                 475                 480 


Met Glu Gly Arg 
                


<210>  107
<211>  243
<212>  PRT
<213>  S. pneumoniae

<400>  107

Met Ile Asp Ile His Ser His Ile Val Phe Asp Val Asp Asp Gly Pro 
1               5                   10                  15      


Lys Ser Arg Glu Glu Ser Lys Ala Leu Leu Ala Glu Ser Tyr Arg Gln 
            20                  25                  30          


Gly Val Arg Ile Ile Val Ser Thr Ser His Arg Arg Lys Gly Met Phe 
        35                  40                  45              


Glu Thr Pro Glu Glu Lys Ile Ala Glu Asn Phe Leu Gln Val Arg Glu 
    50                  55                  60                  


Ile Ala Lys Glu Val Ala Ser Asp Leu Val Ile Ala Tyr Gly Ala Glu 
65                  70                  75                  80  


Ile Tyr Tyr Thr Pro Asp Val Leu Asp Lys Leu Glu Lys Lys Arg Ile 
                85                  90                  95      


Pro Thr Leu Asn Asp Ser Arg Tyr Ala Leu Ile Glu Phe Ser Met Asn 
            100                 105                 110         


Thr Pro Tyr Arg Asp Ile His Ser Ala Leu Ser Lys Ile Leu Met Leu 
        115                 120                 125             


Gly Ile Thr Pro Val Ile Ala His Ile Glu Arg Tyr Asp Ala Leu Glu 
    130                 135                 140                 


Asn Asn Glu Lys Arg Val Arg Glu Leu Ile Asp Met Gly Cys Tyr Thr 
145                 150                 155                 160 


Gln Val Asn Ser Ser His Val Leu Lys Ser Lys Leu Phe Gly Glu Arg 
                165                 170                 175     


Tyr Lys Phe Met Lys Lys Arg Ala Gln Tyr Phe Leu Glu Gln Asp Leu 
            180                 185                 190         


Val His Val Ile Ala Ser Asp Met His Asn Leu Asp Gly Arg Pro Pro 
        195                 200                 205             


His Met Ala Glu Ala Tyr Asp Leu Val Thr Gln Lys Tyr Gly Glu Ala 
    210                 215                 220                 


Lys Ala Gln Glu Leu Phe Ile Asp Asn Pro Arg Lys Ile Val Met Asp 
225                 230                 235                 240 


Gln Leu Ile 
            


<210>  108
<211>  231
<212>  PRT
<213>  S. pneumoniae

<400>  108

Met Met Lys Glu Gln Asn Thr Ile Glu Ile Asp Val Phe Gln Leu Phe 
1               5                   10                  15      


Lys Thr Leu Trp Lys Arg Lys Leu Met Ile Leu Leu Val Ala Leu Val 
            20                  25                  30          


Thr Gly Ala Gly Ala Phe Ala Tyr Ser Ala Phe Ile Val Lys Pro Glu 
        35                  40                  45              


Tyr Thr Ser Thr Thr Arg Ile Tyr Val Val Asn Arg Asp Gln Gly Asp 
    50                  55                  60                  


Lys Ser Gly Leu Thr Asn Gln Asp Leu Gln Ala Gly Ser Tyr Leu Val 
65                  70                  75                  80  


Lys Asp Tyr Arg Glu Ile Ile Leu Ser Gln Asn Val Leu Glu Lys Val 
                85                  90                  95      


Ala Thr Asn Leu Lys Leu Asp Ile Pro Ala Lys Thr Leu Ala Arg Lys 
            100                 105                 110         


Val Gln Val Thr Val Pro Val Asp Thr Arg Ile Val Ser Ile Ser Val 
        115                 120                 125             


Lys Asp Lys Gln Pro Glu Glu Ala Ser Arg Ile Ala Asn Ser Leu Arg 
    130                 135                 140                 


Glu Val Ala Ala Glu Lys Ile Ile Ala Val Thr Arg Val Ser Asp Val 
145                 150                 155                 160 


Thr Thr Leu Glu Glu Ala Arg Pro Ala Thr Thr Pro Ser Ser Pro Asn 
                165                 170                 175     


Val Gly Arg Asn Ser Leu Phe Gly Phe Phe Gly Gly Ala Val Val Thr 
            180                 185                 190         


Val Ile Ala Val Leu Leu Ile Glu Leu Phe Asp Ile Arg Val Lys Arg 
        195                 200                 205             


Pro Glu Asp Val Glu Asp Val Leu Gln Ile Pro Leu Leu Gly Val Val 
    210                 215                 220                 


Pro Asp Leu Asp Lys Met Lys 
225                 230     


<210>  109
<211>  224
<212>  PRT
<213>  S. pneumoniae

<400>  109

Met Pro Thr Leu Glu Ile Ser Gln Ala Lys Leu Asp Phe Val Lys Lys 
1               5                   10                  15      


Ala Glu Glu Asn Tyr Asn Ala Leu Cys Thr Asn Leu Gln Leu Ser Gly 
            20                  25                  30          


Asp Asp Leu Lys Val Phe Ser Ile Thr Ser Val Lys Gln Gly Glu Gly 
        35                  40                  45              


Lys Ser Thr Thr Ser Thr Asn Ile Ala Trp Ala Phe Ala Arg Ala Gly 
    50                  55                  60                  


Tyr Lys Thr Leu Leu Ile Asp Gly Asp Ile Arg Asn Ser Val Met Leu 
65                  70                  75                  80  


Gly Val Phe Lys Ala Arg Asp Lys Ile Thr Gly Leu Thr Glu Phe Leu 
                85                  90                  95      


Ser Gly Thr Thr Asp Leu Ser Gln Gly Leu Cys Asp Thr Asn Ile Glu 
            100                 105                 110         


Asn Leu Phe Val Ile Gln Ala Gly Ser Val Ser Pro Asn Pro Thr Ala 
        115                 120                 125             


Leu Leu Gln Ser Lys Asn Phe Ser Thr Met Leu Glu Thr Leu Arg Lys 
    130                 135                 140                 


Tyr Phe Asp Tyr Ile Ile Val Asp Thr Ala Pro Val Gly Val Val Ile 
145                 150                 155                 160 


Asp Ala Ala Ile Ile Thr Gln Lys Cys Asp Ala Ser Ile Leu Val Thr 
                165                 170                 175     


Lys Ala Gly Glu Ile Asn Arg Arg Asp Ile Gln Lys Ala Lys Glu Gln 
            180                 185                 190         


Leu Glu His Thr Gly Lys Pro Phe Leu Gly Val Val Leu Asn Lys Phe 
        195                 200                 205             


Asp Thr Ser Val Asp Lys Tyr Gly Ser Tyr Gly Asn Tyr Gly Lys Lys 
    210                 215                 220                 


<210>  110
<211>  346
<212>  PRT
<213>  S. pneumoniae

<400>  110

Met Lys Val Thr Ile Ile Gly Gln Ile Lys Asn Lys Arg Thr Gly Leu 
1               5                   10                  15      


Gly Lys Ala Ile Asn Asp Phe Arg Asp Tyr Cys Cys Asn Arg Ala Thr 
            20                  25                  30          


Arg Val Thr Glu Ile Asp Ile Thr Asn Asn Phe Asn Phe Leu Ser Ser 
        35                  40                  45              


Leu Phe Gln Ile Leu Ile Ser Asp Thr Asp Val Tyr Tyr Phe Thr Pro 
    50                  55                  60                  


Ala Gly Ser Val Ala Gly Asn Ile Arg Asp Ser Leu Phe Leu Phe Phe 
65                  70                  75                  80  


Met Ile Met Lys Arg Lys Lys Ile Val Thr His Phe His Asn Ser Ala 
                85                  90                  95      


Phe Gly Asn Val Met Arg Gln His Pro Thr Leu Met Ile Ile Asn Arg 
            100                 105                 110         


Ile Leu Tyr Ser Lys Val Asp Leu Ile Ile Leu Leu Gly Glu Lys Ser 
        115                 120                 125             


Lys Ile Met Phe Gln Gln Leu Arg Ile Leu Asp Glu Lys Phe Lys Ile 
    130                 135                 140                 


Ile Arg Asn Gly Val Asp Gly Tyr Leu Phe Ile Glu Lys Asn Glu Leu 
145                 150                 155                 160 


Asn Lys Lys Met Ser Asp Leu Pro Ile Asn Ile Ile Phe Phe Ser Asn 
                165                 170                 175     


Met Ile Arg Glu Lys Gly Tyr Glu Ile Leu Leu Glu Val Ala Lys Lys 
            180                 185                 190         


Met Val Gly Asp Glu Lys Tyr His Phe Tyr Phe Ser Gly Lys Phe Gln 
        195                 200                 205             


Asp Asn Asn Leu Lys Thr Arg Phe Ile Asn Glu Ile Tyr Ser Met Asn 
    210                 215                 220                 


Asn Val Thr Tyr Leu Asp Gly Val Tyr Gly Ser Asp Lys Lys Lys Leu 
225                 230                 235                 240 


Leu Gln Lys Met His Tyr Phe Val Leu Pro Ser Tyr Tyr Lys Asp Glu 
                245                 250                 255     


Thr Leu Pro Ile Ser Met Leu Glu Ala Met Ala Asn Gly Leu Tyr Ile 
            260                 265                 270         


Ile Val Ser Asp Val Gly Val Val Ser Glu Val Ile Asn Lys Glu Thr 
        275                 280                 285             


Ala Ser Leu Ile Glu Met Ile Asn Glu Glu Thr Ala Asp Ser Ile Ile 
    290                 295                 300                 


Glu Ile Ile Asn Gln Thr Ser Asn Lys Leu Asn Glu Leu Asp Phe Asn 
305                 310                 315                 320 


Val Ser Lys Tyr Lys Gln Glu Leu Leu Asn Glu Asn Ile Gln Ala Ser 
                325                 330                 335     


Ile Tyr Gln Gln Leu Glu Arg Ile Ala Asn 
            340                 345     


<210>  111
<211>  332
<212>  PRT
<213>  S. pneumoniae

<400>  111

Met Thr Lys Lys Lys Asn Thr Gly Lys Ile Leu Thr Val Val Val Pro 
1               5                   10                  15      


Ser Tyr Asn Ala Glu Asn Tyr Leu Gln Glu Thr Met Pro Thr Ile Leu 
            20                  25                  30          


Ser Ala Lys Asn Ile Glu Arg Val Glu Leu Leu Ile Val Asn Asp Gly 
        35                  40                  45              


Ser Thr Asp Arg Thr Glu Glu Ile Ala Arg Gln Phe Glu Arg Glu Tyr 
    50                  55                  60                  


Glu Gly Ile Val Arg Val Ile Ser Lys Glu Asn Cys Gly His Gly Ser 
65                  70                  75                  80  


Ala Val Asn Ala Gly Ile Glu Asn Ala Val Gly Asn Tyr Phe Lys Val 
                85                  90                  95      


Val Asp Ala Asp Asp Trp Val Asn Thr Asn Asn Leu Glu Asp Leu Ile 
            100                 105                 110         


Val Phe Leu Ser Glu Val Asp Val Asp Gln Val Leu Ser Pro Tyr Asp 
        115                 120                 125             


Lys Ile Phe Val Asn Tyr Arg Gly Asp Ile Glu Arg Glu Glu Glu Cys 
    130                 135                 140                 


Asn Glu Phe Ser Gln Val Glu Asn Glu Val Ile Tyr Ser Ala Glu Glu 
145                 150                 155                 160 


Phe Tyr Thr Arg Ile Lys Gln Thr Val Gly Met His Ser Ile Thr Val 
                165                 170                 175     


Lys Thr Ser Leu Leu Gln Glu Asn Asn Ile Arg Leu Ser Glu Lys Met 
            180                 185                 190         


Phe Tyr Val Asp Met Glu Tyr Ile Val Tyr Met Leu Pro Tyr Val Lys 
        195                 200                 205             


Lys Val Val Leu Phe Asp Lys Ser Ile Tyr Arg Tyr Arg Leu Gly Thr 
    210                 215                 220                 


Glu Thr Gln Ser Ile Ser Met Ala Ser Tyr Ile Lys Asn Arg Asp Met 
225                 230                 235                 240 


His Lys Gln Val Ile Tyr His Leu Val Asp Phe Tyr Asn Gln Met Arg 
                245                 250                 255     


Ser Ser Ala Val Leu Arg Arg Ile Thr Trp Lys Leu Ile Leu Asn Leu 
            260                 265                 270         


Ile Arg Gln Gln Trp Ile Ile Tyr Phe Asn Leu Ser Lys Lys Glu Gly 
        275                 280                 285             


Lys Asn Ser Glu Cys Phe Glu Phe Asp Asn Trp Leu Ile Lys Glu Gly 
    290                 295                 300                 


Arg Ile Lys Lys Ile Pro Leu Tyr Phe Phe Lys Ala Val Lys Tyr Ile 
305                 310                 315                 320 


Arg Phe Lys Val Lys Tyr Phe Leu Gly Ile Arg Lys 
                325                 330         


<210>  112
<211>  322
<212>  PRT
<213>  S. pneumoniae

<400>  112

Met Arg Lys Ile Gly Lys Val Ile Asn Glu Tyr Phe Val Leu Arg Lys 
1               5                   10                  15      


Ser Phe Thr Pro Ala Ile Ala Arg Asn Lys Leu Phe Glu Lys Phe Trp 
            20                  25                  30          


Gly Arg Ile Gly Asn Tyr Lys Ile Phe Asn Asn Ile Ala Ser Asn Phe 
        35                  40                  45              


Tyr Gln Tyr Lys His Glu Thr Ile Ile Asn Phe Leu Glu Lys Asp Phe 
    50                  55                  60                  


Ser Gln Phe Leu Lys Ser Tyr Asn Phe Lys Glu Val Ser His Lys Glu 
65                  70                  75                  80  


Ile Glu Gln Arg Lys Ile Phe Ser Met Trp Ile Gln Gly Tyr Glu Ser 
                85                  90                  95      


Ala Pro Lys Leu Val Gln Lys Thr Ile Asp Ser Gln Arg Lys Tyr Ala 
            100                 105                 110         


Glu Lys Tyr Gly Tyr Lys Phe Val Phe Leu Asp Glu Asn Asn Ile Arg 
        115                 120                 125             


Glu Tyr Val Thr Leu Pro Ser Glu Ile Val Glu Lys Tyr Glu Asn Gly 
    130                 135                 140                 


Thr Ile Asp Phe Ile Lys Tyr Ser Asp Val Val Arg Gly Thr Leu Leu 
145                 150                 155                 160 


Ser Lys Tyr Gly Gly Val Trp Leu Asp Ser Thr Ile Tyr Val Asp Ser 
                165                 170                 175     


Ser Arg Glu Leu Asn Tyr Leu Lys Lys Asp Phe Tyr Thr Ile Arg Ala 
            180                 185                 190         


Lys Thr His Glu Arg Val Pro Lys Tyr Ile Ala Asn Gly Arg Trp Ser 
        195                 200                 205             


Ala Phe Cys Leu Ser Gly Glu Lys Gln Asn Ile Val Phe Asp Phe Leu 
    210                 215                 220                 


Glu Lys Phe His Val Ala Tyr Phe Met Lys Tyr Asp Ile Val Leu Asp 
225                 230                 235                 240 


Tyr Phe Leu Ile Asp Tyr Ile Ile Glu Leu Gly Tyr Arg Thr Asn Asp 
                245                 250                 255     


Leu Ile Arg Asn Tyr Ile Asp Lys Val Glu Glu Asn Asn Gln Glu Leu 
            260                 265                 270         


Phe Phe Leu Ala Asp Asn Phe Ser Asn Gln Tyr Asp Glu Lys Glu Trp 
        275                 280                 285             


Ala Gly Val Leu Ser Thr Thr Ala Leu Phe Lys Cys Ser Tyr Lys Cys 
    290                 295                 300                 


Pro Ile Asn Glu Ala Thr Gly Thr Tyr Phe Asp Arg Leu Met Lys Gly 
305                 310                 315                 320 


Glu Leu 
        


<210>  113
<211>  323
<212>  PRT
<213>  S. pneumoniae

<400>  113

Met Ile Ser Val Ile Val Pro Val Tyr Asn Val Ala Asp Tyr Leu Arg 
1               5                   10                  15      


Phe Ala Leu Asp Ser Leu Leu Glu Gln Thr Tyr Lys Asp Phe Glu Val 
            20                  25                  30          


Ile Leu Val Asn Asp Gly Ser Thr Asp Asn Ser Gly Glu Ile Cys Asp 
        35                  40                  45              


Glu Tyr Gly Lys Leu Tyr Asp Asn Ile His Val Phe His Lys Lys Asn 
    50                  55                  60                  


Gly Gly Leu Ser Asp Ala Arg Asn Phe Gly Leu Glu Lys Ser Arg Gly 
65                  70                  75                  80  


Glu Phe Ile Thr Phe Leu Asp Ser Asp Asp Tyr Phe Glu Pro Tyr Ala 
                85                  90                  95      


Leu Glu Leu Leu Ile Thr Ile Gln Lys Lys Tyr Asp Val Asp Ile Val 
            100                 105                 110         


Ser Thr Lys Gly Gly Ile Thr Tyr Ser His Asp Ile Tyr Ser Lys Lys 
        115                 120                 125             


Leu Met Ala Glu Asp Tyr Leu Thr Val Lys Ile Leu Thr Asn Lys Glu 
    130                 135                 140                 


Phe Leu Ala Ala Val Tyr Tyr Asn Asp Glu Met Thr Val Ser Ala Trp 
145                 150                 155                 160 


Gly Lys Leu Tyr Lys Arg Asp Leu Phe Lys Thr Ile Phe Pro Lys Gly 
                165                 170                 175     


Lys Ile Tyr Glu Asp Leu Tyr Val Val Ala Glu Arg Leu Leu Asn Ile 
            180                 185                 190         


Lys Thr Val Ala His Thr Asp Leu Pro Ile Tyr His Tyr Tyr Gln Arg 
        195                 200                 205             


Gln Gly Ser Ile Val Asn Ser Thr Phe Ser Asp Arg Gln Tyr Asp Phe 
    210                 215                 220                 


Phe Asp Ala Ile Asp His Asn Glu Ala Ile Ile Lys Lys Phe Tyr Cys 
225                 230                 235                 240 


Gly Asp Lys Glu Leu Leu Ala Ala Leu Asn Ala Lys Arg Val Ile Gly 
                245                 250                 255     


Ser Phe Ile Leu Ser Asn Ser Ala Phe Tyr Asn Ser Lys Asn Asp Ile 
            260                 265                 270         


Thr Lys Ile Ile Arg Ile Ile Lys Pro Tyr Tyr Trp Glu Val Ile Lys 
        275                 280                 285             


Asn Lys Lys Ile Pro Met Lys Arg Lys Val Gln Cys Val Leu Phe Leu 
    290                 295                 300                 


Leu Ser Pro Asn Tyr Tyr Tyr Lys Ile Lys Asp Lys Met Leu Gln Arg 
305                 310                 315                 320 


Gly Arg Ile 
            


<210>  114
<211>  455
<212>  PRT
<213>  S. pneumoniae

<400>  114

Met Asn Gly Lys Ile Val Lys Pro Ser Leu Ala Ile Ile Gln Ser Phe 
1               5                   10                  15      


Leu Val Ile Leu Leu Thr Tyr Leu Leu Ser Ala Val Arg Glu Ala Glu 
            20                  25                  30          


Ile Val Ser Thr Thr Ala Ile Ala Leu Tyr Ile Leu His Tyr Phe Val 
        35                  40                  45              


Phe Tyr Ile Ser Val Tyr Gly Gln Asp Phe Phe Lys Arg Gly Tyr Leu 
    50                  55                  60                  


Ile Glu Leu Val Gln Thr Leu Lys Tyr Ile Leu Phe Phe Ala Leu Ala 
65                  70                  75                  80  


Ile Ser Ile Ser Asn Phe Phe Leu Glu Asp Arg Phe Ser Ile Ser Arg 
                85                  90                  95      


Arg Gly Met Ile Tyr Phe Leu Thr Leu His Ala Leu Leu Val Tyr Val 
            100                 105                 110         


Leu Asn Leu Phe Ile Lys Trp Tyr Trp Lys Arg Thr Tyr Pro Asn Phe 
        115                 120                 125             


Lys Gly Ser Lys Lys Ile Leu Leu Leu Thr Ala Thr Phe Arg Val Glu 
    130                 135                 140                 


Lys Val Leu Asp Arg Leu Ile Glu Ser Asn Glu Val Val Gly Glu Leu 
145                 150                 155                 160 


Val Ala Val Ser Val Leu Asp Lys Pro Asp Phe Gln His Asp Cys Leu 
                165                 170                 175     


Lys Val Val Ala Glu Gly Glu Ile Val Asn Phe Ala Thr His Glu Val 
            180                 185                 190         


Val Asp Glu Val Phe Ile Asn Leu Pro Ser Glu Lys Tyr Asn Ile Gly 
        195                 200                 205             


Glu Leu Val Ser Gln Phe Glu Thr Met Gly Ile Asp Val Thr Val Asn 
    210                 215                 220                 


Leu Asn Ala Phe Asp Arg Ser Leu Ala Arg Asn Lys Gln Ile Arg Glu 
225                 230                 235                 240 


Met Ala Gly Leu Asn Val Val Thr Phe Ser Thr Thr Phe Tyr Lys Thr 
                245                 250                 255     


Ser His Val Ile Ala Lys Arg Ile Ile Asp Ile Met Gly Ala Leu Val 
            260                 265                 270         


Gly Leu Ile Leu Cys Gly Leu Val Ser Ile Val Leu Val Pro Leu Ile 
        275                 280                 285             


Arg Lys Asp Gly Gly Ser Ala Ile Phe Ala Gln Thr Arg Ile Gly Lys 
    290                 295                 300                 


Asn Gly Arg Gln Phe Thr Phe Tyr Lys Phe Arg Ser Met Cys Val Asp 
305                 310                 315                 320 


Ala Glu Ala Lys Lys Arg Glu Leu Met Glu Gln Asn Thr Met Gln Gly 
                325                 330                 335     


Gly Met Phe Lys Val Asp Asp Asp Pro Arg Ile Thr Lys Ile Gly Arg 
            340                 345                 350         


Phe Ile Arg Lys Thr Ser Leu Asp Glu Leu Pro Gln Phe Tyr Asn Val 
        355                 360                 365             


Leu Lys Gly Asp Met Ser Leu Val Gly Thr Arg Pro Pro Thr Val Asp 
    370                 375                 380                 


Glu Tyr Glu His Tyr Thr Pro Glu Gln Lys Arg Arg Leu Ser Phe Lys 
385                 390                 395                 400 


Pro Gly Val Thr Gly Leu Trp Gln Val Ser Gly Arg Ser Glu Ile Lys 
                405                 410                 415     


Asn Phe Asp Glu Val Val Lys Leu Asp Val Ala Tyr Ile Asp Asp Trp 
            420                 425                 430         


Thr Ile Trp Lys Asp Ile Glu Ile Leu Leu Lys Thr Val Lys Val Val 
        435                 440                 445             


Leu Met Lys Asp Gly Ala Lys 
    450                 455 


<210>  115
<211>  268
<212>  PRT
<213>  S. pneumoniae

<400>  115

Met Glu Arg Ser Arg Leu Ile Asp Val Lys Ile Ile Val Ala Thr His 
1               5                   10                  15      


Lys Glu Val Lys Met Pro Gln Asp Asn Ser Leu Tyr Leu Pro Ile His 
            20                  25                  30          


Val Gly Arg Asp Gly Lys Ser Asp Ile Gly Phe Ile Gly Asp Asn Thr 
        35                  40                  45              


Gly Asp Asn Ile Ser Ser Leu Asn Pro Tyr Tyr Cys Glu Leu Thr Gly 
    50                  55                  60                  


Leu Tyr Trp Ala Trp Lys Asn Leu Asp Tyr Asn Tyr Leu Gly Leu Val 
65                  70                  75                  80  


His Tyr Arg Arg Tyr Phe Thr Asn Lys Ser Gln Gly Tyr Asn Glu Asn 
                85                  90                  95      


Val Asn Met Asp Asp Leu Ile Leu Ser Arg Ala Asn Val Glu Ile Leu 
            100                 105                 110         


Leu Glu Lys Ser Asp Ile Ile Val Pro Lys Lys Arg Lys Tyr Tyr Ile 
        115                 120                 125             


Glu Thr Leu Tyr Ser His Tyr Ala His Thr Leu Asn Gly Glu His Leu 
    130                 135                 140                 


Asp Leu Ala Arg Lys Ile Ile Glu Gln Asn Ser Ser Glu Tyr Leu Ser 
145                 150                 155                 160 


Ser Phe Asp Lys Val Met Lys Gln Arg Ser Gly Tyr Met Phe Asn Met 
                165                 170                 175     


Phe Ile Met Lys Lys Glu Leu Leu Asp Asp Tyr Leu Pro Trp Leu Phe 
            180                 185                 190         


Ser Ile Leu Asp Thr Met Tyr Glu Gln Met Asp Leu Thr Asp Tyr Thr 
        195                 200                 205             


Leu Phe Glu Ser Arg Leu Phe Gly Arg Val Ser Glu Leu Leu Phe Asn 
    210                 215                 220                 


Val Trp Leu Cys Gln Lys Gly Ile Thr Pro Lys Glu Val Pro Phe Met 
225                 230                 235                 240 


Tyr Met Glu Arg Val Asp Leu Phe Glu Lys Gly Lys Ser Phe Leu Met 
                245                 250                 255     


Ala Lys Phe Phe Gly Lys Lys Tyr Gly Gln Ser Phe 
            260                 265             


<210>  116
<211>  226
<212>  PRT
<213>  E. coli

<400>  116

Met Lys Arg Lys Leu Val Asp Phe Cys Ile Ile Ser Leu Pro Gln His 
1               5                   10                  15      


Asn Glu Arg Arg Asp Lys Leu Lys Asn Glu Met Ala Lys Tyr Asp Ile 
            20                  25                  30          


Glu Cys Arg Val Ser His Ala Ile Asp Gly Arg Lys Leu Leu Ala Glu 
        35                  40                  45              


Lys Tyr Phe Ser Leu Phe Lys Ile Arg Ser Ser Lys Met Phe Gly Arg 
    50                  55                  60                  


Gly Phe Leu Thr Pro Ser Glu Leu Gly Cys Phe Leu Ser His Lys Lys 
65                  70                  75                  80  


Ala Leu Thr Glu Phe Leu Ala Ser Gly Arg Lys Trp Leu Val Val Leu 
                85                  90                  95      


Glu Asp Asp Val Leu Pro Lys Glu Asn Val Lys Tyr Leu Asp Glu Met 
            100                 105                 110         


Ile Asn Ser Phe Cys Ser Ser Ser Val Tyr Ile Leu Gly Gly Gln Asp 
        115                 120                 125             


Gly Leu Lys Ser Phe Ser Arg Val Ile Met Gly Arg Lys Ser Ile Cys 
    130                 135                 140                 


Gly Val Arg Lys Val Ile Leu Gly Thr His Arg Trp Leu Tyr Arg Thr 
145                 150                 155                 160 


Cys Cys Tyr Cys Val Asp Ile Lys Gly Ala Glu Arg Ile Leu Arg Leu 
                165                 170                 175     


Met Glu Glu Asn Ser Phe Phe Cys Asp Asp Trp Ser Tyr Ile Val Arg 
            180                 185                 190         


Asn Ala Lys Leu Asp Asn Val Phe Tyr Gly Gln Tyr Phe Ser His Pro 
        195                 200                 205             


Val Asn Leu Asn Ser Ser Ser Ile Glu Ala Glu Arg Leu Phe Ile Ala 
    210                 215                 220                 


Glu Lys 
225     


<210>  117
<211>  251
<212>  PRT
<213>  E. coli

<400>  117

Met Met Gly Leu Phe Met Gly Asn Glu Thr Val Ser Ile Ile Met Pro 
1               5                   10                  15      


Ala Tyr Asn Ala Glu Glu Thr Ile Lys Asp Ser Ile Leu Ser Ile Leu 
            20                  25                  30          


Lys Gln Thr Tyr Glu Asp Phe Lys Leu Tyr Ile Ile Asn Asp Asn Ser 
        35                  40                  45              


Ser Asp Ser Thr Glu His Ile Ile Lys Ser Ile Ile Asp Glu Arg Ile 
    50                  55                  60                  


Val Tyr Leu Leu Asn Arg Asn Gly Lys Gly Val Ser Ser Ala Arg Asn 
65                  70                  75                  80  


Val Gly Ile Ala Ala Cys Asn Gly Arg Tyr Ile Ala Phe Cys Asp Ser 
                85                  90                  95      


Asp Asp Val Trp Phe Glu Thr Lys Leu Glu Glu Gln Leu Lys Ile Leu 
            100                 105                 110         


Ser Ala Gly Asn Tyr Lys Val Val Cys Ser Asn Tyr Glu Val Phe Tyr 
        115                 120                 125             


Ala Asp Thr Asn Val Ile Lys Glu Arg Arg Phe Lys Glu Val Ile Thr 
    130                 135                 140                 


Tyr Asn Asn Met Leu Gln Ser Asn His Ile Gly Asn Leu Thr Gly Ile 
145                 150                 155                 160 


Tyr Asp Ser Thr Gln Ile Gly Lys Val Tyr Gln Gln Glu Ile Gly His 
                165                 170                 175     


Glu Asp Tyr Leu Met Trp Leu Thr Ile Val Lys Lys Ala Lys Leu Val 
            180                 185                 190         


Tyr Cys Ile Gln Lys Asn Leu Ala Arg Tyr Tyr Ile His Asn Thr Gly 
        195                 200                 205             


Leu Ser Ser Asn Lys Phe Thr Ala Ala Met Trp Gln Trp Asn Ile Tyr 
    210                 215                 220                 


Arg Arg Val Leu Ser Phe Ser Leu Phe Lys Ser Leu Val Leu Phe Phe 
225                 230                 235                 240 


Ile Tyr Ser Val Arg Ala Leu Ala Lys Arg Leu 
                245                 250     


<210>  118
<211>  331
<212>  PRT
<213>  E. coli

<400>  118

Met Asn Asp Asn Val Leu Leu Ile Gly Ala Ser Gly Phe Val Gly Thr 
1               5                   10                  15      


Arg Leu Leu Glu Thr Ala Ile Ala Asp Phe Asn Ile Lys Asn Leu Asp 
            20                  25                  30          


Lys Gln Gln Ser His Phe Tyr Pro Glu Ile Thr Gln Ile Gly Asp Val 
        35                  40                  45              


Arg Asp Gln Gln Ala Leu Asp Gln Ala Leu Ala Gly Phe Asp Thr Val 
    50                  55                  60                  


Val Leu Leu Ala Ala Glu His Arg Asp Asp Val Ser Pro Thr Ser Leu 
65                  70                  75                  80  


Tyr Tyr Asp Val Asn Val Gln Gly Thr Arg Asn Val Leu Ala Ala Met 
                85                  90                  95      


Glu Lys Asn Gly Val Lys Asn Ile Ile Phe Thr Ser Ser Val Ala Val 
            100                 105                 110         


Tyr Gly Leu Asn Lys His Asn Pro Asp Glu Asn His Pro His Asp Pro 
        115                 120                 125             


Phe Asn His Tyr Gly Lys Ser Lys Trp Gln Ala Glu Glu Val Leu Arg 
    130                 135                 140                 


Glu Trp Tyr Asn Lys Ala Pro Thr Glu Arg Ser Leu Thr Ile Ile Arg 
145                 150                 155                 160 


Pro Thr Val Ile Phe Gly Glu Arg Asn Arg Gly Asn Val Tyr Asn Leu 
                165                 170                 175     


Leu Lys Gln Ile Ala Gly Gly Lys Phe Met Met Val Gly Ala Gly Thr 
            180                 185                 190         


Asn Tyr Lys Ser Met Ala Tyr Val Gly Asn Ile Val Glu Phe Ile Lys 
        195                 200                 205             


Tyr Lys Leu Lys Asn Val Ala Ala Gly Tyr Glu Val Tyr Asn Tyr Val 
    210                 215                 220                 


Asp Lys Pro Asp Leu Asn Met Asn Gln Leu Val Ala Glu Val Glu Gln 
225                 230                 235                 240 


Ser Leu Asn Lys Lys Ile Pro Ser Met His Leu Pro Tyr Pro Leu Gly 
                245                 250                 255     


Met Leu Gly Gly Tyr Cys Phe Asp Ile Leu Ser Lys Ile Thr Gly Lys 
            260                 265                 270         


Lys Tyr Ala Val Ser Ser Val Arg Val Lys Lys Phe Cys Ala Thr Thr 
        275                 280                 285             


Gln Phe Asp Ala Thr Lys Val His Ser Ser Gly Phe Val Ala Pro Tyr 
    290                 295                 300                 


Thr Leu Ser Gln Gly Leu Asp Arg Thr Leu Gln Tyr Glu Phe Val His 
305                 310                 315                 320 


Ala Lys Lys Asp Asp Ile Thr Phe Val Ser Glu 
                325                 330     


<210>  119
<211>  338
<212>  PRT
<213>  E. coli

<400>  119

Met Arg Val Leu Val Thr Gly Gly Ser Gly Tyr Ile Gly Ser His Thr 
1               5                   10                  15      


Cys Val Gln Leu Leu Gln Asn Gly His Asp Val Ile Ile Leu Asp Asn 
            20                  25                  30          


Leu Cys Asn Ser Lys Arg Ser Val Leu Pro Val Ile Glu Arg Leu Gly 
        35                  40                  45              


Gly Lys His Pro Thr Phe Val Glu Gly Asp Ile Arg Asn Glu Ala Leu 
    50                  55                  60                  


Met Thr Glu Ile Leu His Asp His Ala Ile Asp Thr Val Ile His Phe 
65                  70                  75                  80  


Ala Gly Leu Lys Ala Val Gly Glu Ser Val Gln Lys Pro Leu Glu Tyr 
                85                  90                  95      


Tyr Asp Asn Asn Val Asn Gly Thr Leu Arg Leu Ile Ser Ala Met Arg 
            100                 105                 110         


Ala Ala Asn Val Lys Asn Phe Ile Phe Ser Ser Ser Ala Thr Val Tyr 
        115                 120                 125             


Gly Asp Gln Pro Lys Ile Pro Tyr Val Glu Ser Phe Pro Thr Gly Thr 
    130                 135                 140                 


Pro Gln Ser Pro Tyr Gly Lys Ser Lys Leu Met Val Glu Gln Ile Leu 
145                 150                 155                 160 


Thr Asp Leu Gln Lys Ala Gln Pro Asp Trp Ser Ile Ala Leu Leu Arg 
                165                 170                 175     


Tyr Phe Asn Pro Val Gly Ala His Pro Ser Gly Asp Met Gly Glu Asp 
            180                 185                 190         


Pro Gln Gly Ile Pro Asn Asn Leu Met Pro Tyr Ile Ala Gln Val Ala 
        195                 200                 205             


Val Gly Arg Arg Asp Ser Leu Ala Ile Phe Gly Asn Asp Tyr Pro Thr 
    210                 215                 220                 


Glu Asp Gly Thr Gly Val Arg Asp Tyr Ile His Val Met Asp Leu Ala 
225                 230                 235                 240 


Asp Gly His Val Val Ala Met Glu Lys Leu Ala Asn Lys Pro Gly Val 
                245                 250                 255     


His Ile Tyr Asn Leu Gly Ala Gly Val Gly Asn Ser Val Leu Asp Val 
            260                 265                 270         


Val Asn Ala Phe Ser Lys Ala Cys Gly Lys Pro Val Asn Tyr His Phe 
        275                 280                 285             


Ala Pro Arg Arg Glu Gly Asp Leu Pro Ala Tyr Trp Ala Asp Ala Ser 
    290                 295                 300                 


Lys Ala Asp Arg Glu Leu Asn Trp Arg Val Thr Arg Thr Leu Asp Glu 
305                 310                 315                 320 


Met Ala Gln Asp Thr Trp His Trp Gln Ser Arg His Pro Gln Gly Tyr 
                325                 330                 335     


Pro Asp 
        


<210>  120
<211>  664
<212>  PRT
<213>  Campylobacter jejuni

<400>  120

Ile Ile Ser Asn Asp Gly Tyr Ala Phe Ala Glu Gly Ala Arg Asp Met 
1               5                   10                  15      


Ile Ala Gly Phe His Gln Pro Asn Asp Leu Ser Tyr Tyr Gly Ser Ser 
            20                  25                  30          


Leu Ser Thr Leu Thr Tyr Trp Leu Tyr Lys Ile Thr Pro Phe Ser Phe 
        35                  40                  45              


Glu Ser Ile Ile Leu Tyr Met Ser Thr Phe Leu Ser Ser Leu Val Val 
    50                  55                  60                  


Ile Pro Ile Ile Leu Leu Ala Asn Glu Tyr Lys Arg Pro Leu Met Gly 
65                  70                  75                  80  


Phe Val Ala Ala Leu Leu Ala Ser Ile Ala Asn Ser Tyr Tyr Asn Arg 
                85                  90                  95      


Thr Met Ser Gly Tyr Tyr Asp Thr Asp Met Leu Val Ile Val Leu Pro 
            100                 105                 110         


Met Phe Ile Leu Phe Phe Met Val Arg Met Ile Leu Lys Lys Asp Phe 
        115                 120                 125             


Phe Ser Leu Ile Ala Leu Pro Leu Phe Ile Gly Ile Tyr Leu Trp Trp 
    130                 135                 140                 


Tyr Pro Ser Ser Tyr Thr Leu Asn Val Ala Leu Ile Gly Leu Phe Leu 
145                 150                 155                 160 


Ile Tyr Thr Leu Ile Phe His Arg Lys Glu Lys Ile Phe Tyr Ile Ala 
                165                 170                 175     


Val Ile Leu Ser Ser Leu Thr Leu Ser Asn Ile Ala Trp Phe Tyr Gln 
            180                 185                 190         


Ser Thr Ile Ile Val Ile Leu Phe Ala Leu Phe Ala Leu Glu Gln Lys 
        195                 200                 205             


Arg Leu Asn Phe Val Ile Ile Gly Ile Leu Ala Ser Val Thr Leu Ile 
    210                 215                 220                 


Phe Leu Ile Leu Ser Gly Gly Val Asp Pro Ile Leu Tyr Gln Leu Lys 
225                 230                 235                 240 


Phe Tyr Ile Phe Arg Ser Asp Glu Ser Ala Asn Leu Thr Gln Gly Phe 
                245                 250                 255     


Met Tyr Phe Asn Val Asn Gln Thr Ile Gln Glu Val Glu Asn Val Asp 
            260                 265                 270         


Leu Ser Glu Phe Met Arg Arg Ile Ser Gly Ser Glu Ile Val Phe Leu 
        275                 280                 285             


Phe Ser Leu Phe Gly Phe Val Trp Leu Leu Arg Lys His Lys Ser Met 
    290                 295                 300                 


Ile Met Ala Leu Pro Ile Leu Val Leu Gly Phe Leu Ala Leu Lys Gly 
305                 310                 315                 320 


Gly Leu Arg Phe Thr Ile Tyr Ser Val Pro Val Met Ala Leu Gly Phe 
                325                 330                 335     


Gly Phe Leu Leu Ser Glu Phe Lys Ala Ile Leu Val Lys Lys Tyr Ser 
            340                 345                 350         


Gln Leu Thr Ser Asn Val Cys Ile Val Phe Ala Thr Ile Leu Thr Leu 
        355                 360                 365             


Ala Pro Val Phe Ile His Ile Tyr Asn Tyr Lys Ala Pro Thr Val Phe 
    370                 375                 380                 


Ser Gln Asn Glu Ala Ser Leu Leu Asn Gln Leu Lys Asn Ile Ala Asn 
385                 390                 395                 400 


Arg Glu Asp Tyr Val Val Thr Trp Trp Asp Tyr Gly Tyr Pro Val Arg 
                405                 410                 415     


Tyr Tyr Ser Asp Val Lys Thr Leu Val Asp Gly Gly Lys His Leu Gly 
            420                 425                 430         


Lys Asp Asn Phe Phe Pro Ser Phe Ala Leu Ser Lys Asp Glu Gln Ala 
        435                 440                 445             


Ala Ala Asn Met Ala Arg Leu Ser Val Glu Tyr Thr Glu Lys Ser Phe 
    450                 455                 460                 


Tyr Ala Pro Gln Asn Asp Ile Leu Lys Thr Asp Ile Leu Gln Ala Met 
465                 470                 475                 480 


Met Lys Asp Tyr Asn Gln Ser Asn Val Asp Leu Phe Leu Ala Ser Leu 
                485                 490                 495     


Ser Lys Pro Asp Phe Lys Ile Asp Thr Pro Lys Thr Arg Asp Ile Tyr 
            500                 505                 510         


Leu Tyr Met Pro Ala Arg Met Ser Leu Ile Phe Ser Thr Val Ala Ser 
        515                 520                 525             


Phe Ser Phe Ile Asn Leu Asp Thr Gly Val Leu Asp Lys Pro Phe Thr 
    530                 535                 540                 


Phe Ser Thr Ala Tyr Pro Leu Asp Val Lys Asn Gly Glu Ile Tyr Leu 
545                 550                 555                 560 


Ser Asn Gly Val Val Leu Ser Asp Asp Phe Arg Ser Phe Lys Ile Gly 
                565                 570                 575     


Asp Asn Val Val Ser Val Asn Ser Ile Val Glu Ile Asn Ser Ile Lys 
            580                 585                 590         


Gln Gly Glu Tyr Lys Ile Thr Pro Ile Asp Asp Lys Ala Gln Phe Tyr 
        595                 600                 605             


Ile Phe Tyr Leu Lys Asp Ser Ala Ile Pro Tyr Ala Gln Phe Ile Leu 
    610                 615                 620                 


Met Asp Lys Thr Met Phe Asn Ser Ala Tyr Val Gln Met Phe Phe Leu 
625                 630                 635                 640 


Gly Asn Tyr Asp Lys Asn Leu Phe Asp Leu Val Ile Asn Ser Arg Asp 
                645                 650                 655     


Ala Lys Val Phe Lys Leu Lys Ile 
            660                 


