                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> METHODS OF TREATING BONE LOSS

<130> UCDVP126WO

<140> PCT/US2017/036552
<141> 2017-06-08

<150> 62/348,144
<151> 2016-06-10

<160> 38    

<170> PatentIn version 3.5

<210> 1
<211> 554
<212> PRT
<213> Homo sapiens

<400> 1
Met Thr Leu Arg Gly Ala Val Phe Asp Leu Asp Gly Val Leu Ala Leu 
1               5                   10                  15      


Pro Ala Val Phe Gly Val Leu Gly Arg Thr Glu Glu Ala Leu Ala Leu 
            20                  25                  30          


Pro Arg Gly Leu Leu Asn Asp Ala Phe Gln Lys Gly Gly Pro Glu Gly 
        35                  40                  45              


Ala Thr Thr Arg Leu Met Lys Gly Glu Ile Thr Leu Ser Gln Trp Ile 
    50                  55                  60                  


Pro Leu Met Glu Glu Asn Cys Arg Lys Cys Ser Glu Thr Ala Lys Val 
65                  70                  75                  80  


Cys Leu Pro Lys Asn Phe Ser Ile Lys Glu Ile Phe Asp Lys Ala Ile 
                85                  90                  95      


Ser Ala Arg Lys Ile Asn Arg Pro Met Leu Gln Ala Ala Leu Met Leu 
            100                 105                 110         


Arg Lys Lys Gly Phe Thr Thr Ala Ile Leu Thr Asn Thr Trp Leu Asp 
        115                 120                 125             


Asp Arg Ala Glu Arg Asp Gly Leu Ala Gln Leu Met Cys Glu Leu Lys 
    130                 135                 140                 


Met His Phe Asp Phe Leu Ile Glu Ser Cys Gln Val Gly Met Val Lys 
145                 150                 155                 160 


Pro Glu Pro Gln Ile Tyr Lys Phe Leu Leu Asp Thr Leu Lys Ala Ser 
                165                 170                 175     


Pro Ser Glu Val Val Phe Leu Asp Asp Ile Gly Ala Asn Leu Lys Pro 
            180                 185                 190         


Ala Arg Asp Leu Gly Met Val Thr Ile Leu Val Gln Asp Thr Asp Thr 
        195                 200                 205             


Ala Leu Lys Glu Leu Glu Lys Val Thr Gly Ile Gln Leu Leu Asn Thr 
    210                 215                 220                 


Pro Ala Pro Leu Pro Thr Ser Cys Asn Pro Ser Asp Met Ser His Gly 
225                 230                 235                 240 


Tyr Val Thr Val Lys Pro Arg Val Arg Leu His Phe Val Glu Leu Gly 
                245                 250                 255     


Trp Pro Ala Val Cys Leu Cys His Gly Phe Pro Glu Ser Trp Tyr Ser 
            260                 265                 270         


Trp Arg Tyr Gln Ile Pro Ala Leu Ala Gln Ala Gly Tyr Arg Val Leu 
        275                 280                 285             


Ala Met Asp Met Lys Gly Tyr Gly Glu Ser Ser Ala Pro Pro Glu Ile 
    290                 295                 300                 


Glu Glu Tyr Cys Met Glu Val Leu Cys Lys Glu Met Val Thr Phe Leu 
305                 310                 315                 320 


Asp Lys Leu Gly Leu Ser Gln Ala Val Phe Ile Gly His Asp Trp Gly 
                325                 330                 335     


Gly Met Leu Val Trp Tyr Met Ala Leu Phe Tyr Pro Glu Arg Val Arg 
            340                 345                 350         


Ala Val Ala Ser Leu Asn Thr Pro Phe Ile Pro Ala Asn Pro Asn Met 
        355                 360                 365             


Ser Pro Leu Glu Ser Ile Lys Ala Asn Pro Val Phe Asp Tyr Gln Leu 
    370                 375                 380                 


Tyr Phe Gln Glu Pro Gly Val Ala Glu Ala Glu Leu Glu Gln Asn Leu 
385                 390                 395                 400 


Ser Arg Thr Phe Lys Ser Leu Phe Arg Ala Ser Asp Glu Ser Val Leu 
                405                 410                 415     


Ser Met His Lys Val Cys Glu Ala Gly Gly Leu Phe Val Asn Ser Pro 
            420                 425                 430         


Glu Glu Pro Ser Leu Ser Arg Met Val Thr Glu Glu Glu Ile Gln Phe 
        435                 440                 445             


Tyr Val Gln Gln Phe Lys Lys Ser Gly Phe Arg Gly Pro Leu Asn Trp 
    450                 455                 460                 


Tyr Arg Asn Met Glu Arg Asn Trp Lys Trp Ala Cys Lys Ser Leu Gly 
465                 470                 475                 480 


Arg Lys Ile Leu Ile Pro Ala Leu Met Val Thr Ala Glu Lys Asp Phe 
                485                 490                 495     


Val Leu Val Pro Gln Met Ser Gln His Met Glu Asp Trp Ile Pro His 
            500                 505                 510         


Leu Lys Arg Gly His Ile Glu Asp Cys Gly His Trp Thr Gln Met Asp 
        515                 520                 525             


Lys Pro Thr Glu Val Asn Gln Ile Leu Ile Lys Trp Leu Asp Ser Asp 
    530                 535                 540                 


Ala Arg Asn Pro Pro Val Val Ser Lys Met 
545                 550                 


<210> 2
<211> 2100
<212> DNA
<213> Homo sapiens

<400> 2
ggcacgagct ctctctctct ctctctctct ctctcgccgc catgacgctg cgcggcgccg       60

tcttcgacct tgacggggtg ctggcgctgc cagcggtgtt cggcgtcctc ggccgcacgg      120

aggaggccct ggcgctgccc agaggacttc tgaatgatgc tttccagaaa gggggaccag      180

agggtgccac tacccggctt atgaaaggag agatcacact ttcccagtgg ataccactca      240

tggaagaaaa ctgcaggaag tgctccgaga ccgctaaagt ctgcctcccc aagaatttct      300

ccataaaaga aatctttgac aaggcgattt cagccagaaa gatcaaccgc cccatgctcc      360

aggcagctct catgctcagg aagaaaggat tcactactgc catcctcacc aacacctggc      420

tggacgaccg tgctgagaga gatggcctgg cccagctgat gtgtgagctg aagatgcact      480

ttgacttcct gatagagtcg tgtcaggtgg gaatggtcaa acctgaacct cagatctaca      540

agtttctgct ggacaccctg aaggccagcc ccagtgaggt cgtttttttg gatgacatcg      600

gggctaatct gaagccagcc cgtgacttgg gaatggtcac catcctggtc caggacactg      660

acacggccct gaaagaactg gagaaagtga ccggaatcca gcttctcaat accccggccc      720

ctctgccgac ctcttgcaat ccaagtgaca tgagccatgg gtacgtgaca gtaaagccca      780

gggtccgtct gcattttgtg gagctgggct ggcctgctgt gtgcctctgc catggatttc      840

ccgagagttg gtattcttgg aggtaccaga tccctgctct ggcccaggca ggttaccggg      900

tcctagctat ggacatgaaa ggctatggag agtcatctgc tcctcccgaa atagaagaat      960

attgcatgga agtgttatgt aaggagatgg taaccttcct ggataaactg ggcctctctc     1020

aagcagtgtt cattggccat gactggggtg gcatgctggt gtggtacatg gctctcttct     1080

accccgagag agtgagggcg gtggccagtt tgaatactcc cttcatacca gcaaatccca     1140

acatgtcccc tttggagagt atcaaagcca acccagtatt tgattaccag ctctacttcc     1200

aagaaccagg agtggctgag gctgaactgg aacagaacct gagtcggact ttcaaaagcc     1260

tcttcagagc aagcgatgag agtgttttat ccatgcataa agtctgtgaa gcgggaggac     1320

tttttgtaaa tagcccagaa gagcccagcc tcagcaggat ggtcactgag gaggaaatcc     1380

agttctatgt gcagcagttc aagaagtctg gtttcagagg tcctctaaac tggtaccgaa     1440

acatggaaag gaactggaag tgggcttgca aaagcttggg acggaagatc ctgattccgg     1500

ccctgatggt cacggcggag aaggacttcg tgctcgttcc tcagatgtcc cagcacatgg     1560

aggactggat tccccacctg aaaaggggac acattgagga ctgtgggcac tggacacaga     1620

tggacaagcc aaccgaggtg aatcagatcc tcattaagtg gctggattct gatgcccgga     1680

acccaccggt ggtctcaaag atgtagaacg cagcgtagtg cccacgctca gcaggtgtgc     1740

catccttcca cctgctgggg caccattctt agtatacaga ggtggcctta cacacatctt     1800

gcatggatgg cagcattgtt ctgaaggggt ttgcagaaaa aaaagatttt ctttacataa     1860

agtgaatcaa atttgacatt attttagatc ccagagaaat caggtgtgat tagttctcca     1920

ggcatgaatg catcgtccct ttatctgtaa gaacccttag tgtcctgtag ggggacagaa     1980

tggggtggcc aggtggtgat ttctctttga ccaatgcata gtttggcaga aaaatcagcc     2040

gttcatttag aagaatctta gcagagattg ggatgcctta ctcaataaag ctaagatgac     2100


<210> 3
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
cagtgttcat tggccatgac tgg                                               23


<210> 4
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 4
guguucauug gccaugacut t                                                 21


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 5
agucauggcc aaugaacact t                                                 21


<210> 6
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gaaaggctat ggagagtcat ctg                                               23


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 7
aaggcuaugg agagucauct t                                                 21


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 8
gaugacucuc cauagccuut t                                                 21


<210> 9
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
aaaggctatg gagagtcatc tgc                                               23


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 10
aggcuaugga gagucaucut t                                                 21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 11
agaugacucu ccauagccut t                                                 21


<210> 12
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
caagcagtgt tcattggcca tga                                               23


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 13
agcaguguuc auuggccaut t                                                 21


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 14
auggccaaug aacacugcut t                                                 21


<210> 15
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
cagcacatgg aggactggat tcc                                               23


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 16
gcacauggag gacuggauut t                                                 21


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 17
aauccagucc uccaugugct t                                                 21


<210> 18
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
ttcaagaga                                                                9


<210> 19
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
cagtgttcat tggccatgac tgg                                               23


<210> 20
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
gatccccgtg ttcattggcc atgactttca agagaagtca tggccaatga acacttttt        59


<210> 21
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
agctaaaaag tgttcattgg ccatgacttc tcttgaaagt catggccaat gaacacggg        59


<210> 22
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
gaaaggctat ggagagtcat ctg                                               23


<210> 23
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
gatccccaag gctatggaga gtcatcttca agagagatga ctctccatag ccttttttt        59


<210> 24
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
agctaaaaaa aggctatgga gagtcatctc tcttgaagat gactctccat agccttggg        59


<210> 25
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
aaaggctatg gagagtcatc tgc                                               23


<210> 26
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gatccccagg ctatggagag tcatctttca agagaagatg actctccata gcctttttt        59


<210> 27
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
agctaaaaaa ggctatggag agtcatcatc tcttgaaaga tgactctcca tagcctggg        59


<210> 28
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
caagcagtgt tcattggcca tga                                               23


<210> 29
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
gatccccagc agtgttcatt ggccatttca agagaatggc caatgaacac tgctttttt        59


<210> 30
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
agctaaaaaa gcagtgttca ttggccattc tcttgaaatg gccaatgaac actgctggg        59


<210> 31
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
cagcacatgg aggactggat tcc                                               23


<210> 32
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
gatccccgca catggaggac tggattttca agagaaatcc agtcctccat gtgcttttt        59


<210> 33
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
agctaaaaag cacatggagg actggatttc tcttgaaaat ccagtcctcc atgtgcggg        59


<210> 34
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
uguccagugc ccacaguccu                                                   20


<210> 35
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
uucccaccug acacgacucu                                                   20


<210> 36
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
guucagccuc agccacuccu                                                   20


<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
aguccucccg cuucacaga                                                    19


<210> 38
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
gcccacuucc aguuccuuuc c                                                 21


