                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
	  Rutkoski, Thomas
        Teplyakov, Alexey
        Wunderler, Nicole
 
<120>  GM-CSF variants and methods of use

<130>  JBI5088WOPCT

<140>  To Be Assigned
<141>  2017-06-07

<150>  62/347,342
<151>  2016-06-08

<150>  62/374,068
<151>  2016-08-12

<150>  62/423,857
<151>  2016-11-18

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  2
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S29C/S69C GM-CSF variant

<400>  2

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Cys Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Cys Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  3
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L49P  GM-CSF variant

<400>  3

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Pro Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  4
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K107I variant

<400>  4

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Ile Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  5
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R23L  GM-CSF variant

<400>  5

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Leu Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  6
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S29C/S69C/L49P  GM-CSF variant

<400>  6

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Cys Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Pro Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Cys Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  7
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S29C/S69C/K107I  GM-CSF variant

<400>  7

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Cys Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Cys Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Ile Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  8
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S29C/S69C/R23L/L49P/K107I  GM-CSF variant

<400>  8

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Leu Arg Leu Leu Asn Leu Cys Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Pro Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Cys Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Ile Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  9
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S29C/S69C/L49P/K107I  GM-CSF variant

<400>  9

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Cys Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Pro Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Cys Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Ile Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  10
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S29C/S69C GM-CSF variant DNA

<400>  10
gcccccgccc gctccccctc cccatcgacc caaccctggg aacacgtgaa cgccattcag       60

gaggctagga gactgctgaa cctgtgccgg gataccgcag ccgagatgaa cgaaaccgtg      120

gaggtcatct ccgaaatgtt tgacttgcaa gaacctactt gtctgcaaac tcgcctcgag      180

ctgtacaaac agggactccg gggatgtctc actaagctga aggggcctct gaccatgatg      240

gcctcccact acaagcagca ctgcccgccg acgccggaaa ccagctgcgc gacccagatc      300

attaccttcg aatcgttcaa ggaaaacctg aaggacttcc tgcttgtgat cccgttcgac      360

tgctgggagc ctgtgcagga gtgataa                                          387


<210>  11
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L49P GM-CSF variant DNA

<400>  11
gcccccgccc gctccccctc cccatcgacc caaccctggg aacacgtgaa cgccattcag       60

gaggctagga gactgctgaa cctgtcccgg gataccgcag ccgagatgaa cgaaaccgtg      120

gaggtcatct ccgaaatgtt tgacccacaa gaacctactt gtctgcaaac tcgcctcgag      180

ctgtacaaac agggactccg gggaagcctc actaagctga aggggcctct gaccatgatg      240

gcctcccact acaagcagca ctgcccgccg acgccggaaa ccagctgcgc gacccagatc      300

attaccttcg aatcgttcaa ggaaaacctg aaggacttcc tgcttgtgat cccgttcgac      360

tgctgggagc ctgtgcagga gtgataa                                          387


<210>  12
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K107I  GM-CSF variant DNA

<400>  12
gcccccgccc gctccccctc cccatcgacc caaccctggg aacacgtgaa cgccattcag       60

gaggctagga gactgctgaa cctgtcccgg gataccgcag ccgagatgaa cgaaaccgtg      120

gaggtcatct ccgaaatgtt tgacttgcaa gaacctactt gtctgcaaac tcgcctcgag      180

ctgtacaaac agggactccg gggaagcctc actaagctga aggggcctct gaccatgatg      240

gcctcccact acaagcagca ctgcccgccg acgccggaaa ccagctgcgc gacccagatc      300

attaccttcg aatcgttcat cgaaaacctg aaggacttcc tgcttgtgat cccgttcgac      360

tgctgggagc ctgtgcagga gtgataa                                          387


<210>  13
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  R23L GM-CSF variant DNA

<400>  13
gcccccgccc gctccccctc cccatcgacc caaccctggg aacacgtgaa cgccattcag       60

gaggctctta gactgctgaa cctgtcccgg gataccgcag ccgagatgaa cgaaaccgtg      120

gaggtcatct ccgaaatgtt tgacttgcaa gaacctactt gtctgcaaac tcgcctcgag      180

ctgtacaaac agggactccg gggaagcctc actaagctga aggggcctct gaccatgatg      240

gcctcccact acaagcagca ctgcccgccg acgccggaaa ccagctgcgc gacccagatc      300

attaccttcg aatcgttcaa ggaaaacctg aaggacttcc tgcttgtgat cccgttcgac      360

tgctgggagc ctgtgcagga gtgataa                                          387


<210>  14
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S29C/S69C/L49P  GM-CSF variant DNA

<400>  14
gcccccgccc gctccccctc cccatcgacc caaccctggg aacacgtgaa cgccattcag       60

gaggctagga gactgctgaa cctgtgccgg gataccgcag ccgagatgaa cgaaaccgtg      120

gaggtcatct ccgaaatgtt tgacccacaa gaacctactt gtctgcaaac tcgcctcgag      180

ctgtacaaac agggactccg gggatgtctc actaagctga aggggcctct gaccatgatg      240

gcctcccact acaagcagca ctgcccgccg acgccggaaa ccagctgcgc gacccagatc      300

attaccttcg aatcgttcaa ggaaaacctg aaggacttcc tgcttgtgat cccgttcgac      360

tgctgggagc ctgtgcagga gtgataa                                          387


<210>  15
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S29C/S69C/K107I GM-CSF variant DNA

<400>  15
gcccccgccc gctccccctc cccatcgacc caaccctggg aacacgtgaa cgccattcag       60

gaggctagga gactgctgaa cctgtgccgg gataccgcag ccgagatgaa cgaaaccgtg      120

gaggtcatct ccgaaatgtt tgacttgcaa gaacctactt gtctgcaaac tcgcctcgag      180

ctgtacaaac agggactccg gggatgtctc actaagctga aggggcctct gaccatgatg      240

gcctcccact acaagcagca ctgcccgccg acgccggaaa ccagctgcgc gacccagatc      300

attaccttcg aatcgttcat cgaaaacctg aaggacttcc tgcttgtgat cccgttcgac      360

tgctgggagc ctgtgcagga gtgataa                                          387


<210>  16
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S29C/S69C/R23L/L49P/K107I  GM-CSF variant DNA

<400>  16
gcccccgccc gctccccctc cccatcgacc caaccctggg aacacgtgaa cgccattcag       60

gaggctttga gactgctgaa cctgtgccgg gataccgcag ccgagatgaa cgaaaccgtg      120

gaggtcatct ccgaaatgtt tgacccacaa gaacctactt gtctgcaaac tcgcctcgag      180

ctgtacaaac agggactccg gggatgcctc actaagctga aggggcctct gaccatgatg      240

gcctcccact acaagcagca ctgcccgccg acgccggaaa ccagctgcgc gacccagatc      300

attaccttcg aatcgttcat cgaaaacctg aaggacttcc tgcttgtgat cccgttcgac      360

tgctgggagc ctgtgcagga gtgataa                                          387


<210>  17
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S29C/S69C/L49P/K107I  GM-CSF variant DNA

<400>  17
gcccccgccc gctccccctc cccatcgacc caaccctggg aacacgtgaa cgccattcag       60

gaggctagga gactgctgaa cctgtgccgg gataccgcag ccgagatgaa cgaaaccgtg      120

gaggtcatct ccgaaatgtt tgacccacaa gaacctactt gtctgcaaac tcgcctcgag      180

ctgtacaaac agggactccg gggatgtctc actaagctga aggggcctct gaccatgatg      240

gcctcccact acaagcagca ctgcccgccg acgccggaaa ccagctgcgc gacccagatc      300

attaccttcg aatcgttcat cgaaaacctg aaggacttcc tgcttgtgat cccgttcgac      360

tgctgggagc ctgtgcagga gtgataa                                          387


<210>  18
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  18
gcccccgccc gctccccctc cccatcgacc caaccctggg aacacgtgaa cgccattcag       60

gaggctagga gactgctgaa cctgtcccgg gataccgcag ccgagatgaa cgaaaccgtg      120

gaggtcatct ccgaaatgtt tgacttgcaa gaacctactt gtctgcaaac tcgcctcgag      180

ctgtacaaac agggactccg gggaagcctc actaagctga aggggcctct gaccatgatg      240

gcctcccact acaagcagca ctgcccgccg acgccggaaa ccagctgcgc gacccagatc      300

attaccttcg aatcgttcaa ggaaaacctg aaggacttcc tgcttgtgat cccgttcgac      360

tgctgggagc ctgtgcagga gtaa                                             384


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  19

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ile Gln Ala 
            


<210>  20
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1FU1 linker

<400>  20

Ala Ser Leu Asp Thr Thr Ala Glu Asn Gln Ala Lys Asn Glu His Leu 
1               5                   10                  15      


Gln Lys Glu Asn Glu Arg Leu Leu Arg Asp Trp Asn Asp Val Gln Gly 
            20                  25                  30          


Arg Phe Glu Lys Gly Ser 
        35              


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1DC1(13AA)2 linker

<400>  21

Ala Ser Glu Lys Asn Lys Arg Ser Thr Pro Tyr Ile Glu Arg Ala Glu 
1               5                   10                  15      


Lys Asn Lys Arg Ser Thr Pro Tyr Ile Glu Arg Ala Gly Ser 
            20                  25                  30  


<210>  22
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1DC1(13AA)3  linker

<400>  22

Ala Ser Glu Lys Asn Lys Arg Ser Thr Pro Tyr Ile Glu Arg Ala Glu 
1               5                   10                  15      


Lys Asn Lys Arg Ser Thr Pro Tyr Ile Glu Arg Ala Glu Lys Asn Lys 
            20                  25                  30          


Arg Ser Thr Pro Tyr Ile Glu Arg Ala Gly Ser 
        35                  40              


<210>  23
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS(AP)10GS  linker

<400>  23

Ala Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Gly Ser 
            20                  


<210>  24
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AS(AP)20GS linker

<400>  24

Ala Ser Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Gly Ser 
        35                  40                  


<210>  25
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (EAAAK)4 linker

<400>  25

Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Ala Gly Ser 
            20                  25      


<210>  26
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (EAAAK)8  linker

<400>  26

Ala Ser Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
1               5                   10                  15      


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
            20                  25                  30          


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Gly Ser 
        35                  40                  45      


<210>  27
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS(G4S)4 linker

<400>  27

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser 
            20          


<210>  28
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS(G4S)8 linker

<400>  28

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40          


<210>  29
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS12X(G4S) linker

<400>  29

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60          


<210>  30
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS16X(G4S) linker

<400>  30

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
65                  70                  75                  80  


Gly Ser 
        


<210>  31
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ile Gln Ala 
            


<210>  32
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  32
atggcctggg tgtggaccct gctgttcctg atggccgccg cccagagcat ccaggcc          57


<210>  33
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Genus sequence


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa may be R or L

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa may be L or P

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa may be K or I

<400>  33

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Xaa Arg Leu Leu Asn Leu Cys Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Xaa Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Cys Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Xaa Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


