                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> IDENTIFICATION OF A T CELL EPITOPE OF PREVOTELLA COPRI THAT 
      INDUCES T CELL RESPONSES IN PATIENTS WITH RHEUMATOID ARTHRITIS

<130> 030258-087241-PCT

<140> PCT/US2017/036198
<141> 2017-06-06

<150> 62/346,666
<151> 2016-06-07

<160> 46    

<170> PatentIn version 3.5

<210> 1
<211> 223
<212> PRT
<213> Prevotella copri

<400> 1
Met Lys Arg Ile Ile Leu Ile Leu Thr Val Leu Leu Ala Met Leu Gly 
1               5                   10                  15      


Gln Val Ala Tyr Ala Gln Lys Thr Cys Val Ile Ala Ser Ala Glu Asn 
            20                  25                  30          


His Val Pro Ile Arg Glu Ala Leu Ile His Thr Asn Asn Asn His Trp 
        35                  40                  45              


Ala Arg Thr Asp Tyr Arg Gly Tyr Trp Thr Met Arg Tyr Gln Phe Asp 
    50                  55                  60                  


Ser Ala Thr Val Ser Lys Pro Gly Phe Met Lys Ala Thr Ile Arg Tyr 
65                  70                  75                  80  


Lys Glu Leu Pro Asp Thr Leu Phe Leu Leu Pro Asp Ala Lys Gln Leu 
                85                  90                  95      


Gly Glu Val Thr Val Trp Gly Lys Asn Gln Glu Gly Ile Lys Asn Met 
            100                 105                 110         


Glu Glu Asp Ile Gln Glu Lys Ile Asn Ser Leu Pro Thr Ser Ser Thr 
        115                 120                 125             


Gly Ile Gly Phe Asp Ala Phe Gly Trp Met Asp Lys Gln Gly Lys Arg 
    130                 135                 140                 


Asp Lys Lys His Leu Gln Gln Ala Lys Lys Val Phe Glu Lys Met Glu 
145                 150                 155                 160 


His Lys Asp Pro Val Val Ala Ala Tyr Glu Lys Ala Thr Gly Lys Lys 
                165                 170                 175     


Tyr Glu Leu Thr Asn Pro Tyr Asp Val Ser Ala Phe Lys Lys Asp Pro 
            180                 185                 190         


Pro Ser Glu Met Ala Thr Glu Glu Lys Lys Ala Thr Ser Asp Ala Glu 
        195                 200                 205             


Ser Lys Ser Lys Lys Lys Glu Asn Pro Glu Lys Tyr Ala Gln Glu 
    210                 215                 220             


<210> 2
<211> 19
<212> PRT
<213> Prevotella copri

<400> 2
Lys Arg Ile Ile Leu Ile Leu Thr Val Leu Leu Ala Met Leu Gly Gln 
1               5                   10                  15      


Val Ala Tyr 
            


<210> 3
<211> 18
<212> PRT
<213> Prevotella copri

<400> 3
Asp Tyr Arg Gly Tyr Trp Thr Met Arg Tyr Gln Phe Asp Ser Ala Thr 
1               5                   10                  15      


Val Ser 
        


<210> 4
<211> 13
<212> PRT
<213> Prevotella copri

<400> 4
Glu Lys Ile Asn Ser Leu Pro Thr Ser Ser Thr Gly Ile 
1               5                   10              


<210> 5
<211> 19
<212> PRT
<213> Prevotella copri


<220>
<221> MOD_RES
<222> (16)..(16)
<223> Gln(deamidated)

<400> 5
Lys Arg Ile Ile Leu Ile Leu Thr Val Leu Leu Ala Met Leu Gly Gln 
1               5                   10                  15      


Val Ala Tyr 
            


<210> 6
<211> 19
<212> PRT
<213> Prevotella copri

<400> 6
Lys Arg Ile Ile Leu Ile Leu Thr Val Leu Leu Ala Met Leu Gly Gln 
1               5                   10                  15      


Val Ala Tyr 
            


<210> 7
<211> 18
<212> PRT
<213> Prevotella copri

<400> 7
Asp Tyr Arg Gly Tyr Trp Thr Met Arg Tyr Gln Phe Asp Ser Ala Thr 
1               5                   10                  15      


Val Ser 
        


<210> 8
<211> 13
<212> PRT
<213> Prevotella copri

<400> 8
Glu Lys Ile Asn Ser Leu Pro Thr Ser Ser Thr Gly Ile 
1               5                   10              


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
ccaagtagcg tgcaggatga                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
ttcaagcccg ggtaaggttc                                                   20


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
cgcggtaata cggaaggtcc                                                   20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gatacccgca ctttcgagct                                                   20


<210> 13
<211> 13
<212> PRT
<213> Homo sapiens

<400> 13
Pro Asn Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu 
1               5                   10              


<210> 14
<211> 14
<212> PRT
<213> Homo sapiens

<400> 14
Phe Glu Pro Phe Phe Met Met Ile Ala Thr Pro Ala Pro His 
1               5                   10                  


<210> 15
<211> 15
<212> PRT
<213> Homo sapiens

<400> 15
Thr Tyr Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu Gln 
1               5                   10                  15  


<210> 16
<211> 15
<212> PRT
<213> Homo sapiens

<400> 16
Asn Tyr Arg Leu Met Met Leu Gln Ser Cys Ser Gly Pro Thr Cys 
1               5                   10                  15  


<210> 17
<211> 16
<212> PRT
<213> Homo sapiens

<400> 17
Asp Gly Leu Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Lys 
1               5                   10                  15      


<210> 18
<211> 15
<212> PRT
<213> Homo sapiens

<400> 18
Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala Ile Val Asp Gly 
1               5                   10                  15  


<210> 19
<211> 13
<212> PRT
<213> Homo sapiens

<400> 19
Val Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly 
1               5                   10              


<210> 20
<211> 15
<212> PRT
<213> Homo sapiens

<400> 20
Asn Pro Ala Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly 
1               5                   10                  15  


<210> 21
<211> 14
<212> PRT
<213> Homo sapiens

<400> 21
Phe Glu Pro Phe Phe Met Met Ile Ala Thr Pro Ala Pro His 
1               5                   10                  


<210> 22
<211> 14
<212> PRT
<213> Prevotella sp. DNF00663

<400> 22
Lys Lys Pro Phe Phe Met Met Val Ala Met Asn Pro Pro His 
1               5                   10                  


<210> 23
<211> 14
<212> PRT
<213> Parabacteroides sp. HGS0025

<400> 23
Asp Val Pro Phe Phe Met Met Trp Thr Thr Pro Leu Pro His 
1               5                   10                  


<210> 24
<211> 15
<212> PRT
<213> Homo sapiens

<400> 24
Asn Pro Ala Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly 
1               5                   10                  15  


<210> 25
<211> 13
<212> PRT
<213> Prevotella sp. HUN102

<400> 25
Gln Gly Phe Val Val Lys Thr Ala Asn Ala Gly Ala Leu 
1               5                   10              


<210> 26
<211> 13
<212> PRT
<213> Butyricimonas sp. Marseille-P2440

<400> 26
Ala Asn Phe Met Ile Asn Val Ser Asn Ala Gly Ala Leu 
1               5                   10              


<210> 27
<211> 50
<212> DNA
<213> Prevotella copri

<400> 27
gaaatgtaga cgctcaacgt ctgcactgca gcgcgaactg gtttccttga                  50


<210> 28
<211> 50
<212> DNA
<213> Prevotella copri

<400> 28
gaaaaatacc ggctcaaccg gtatcctgca gcgcgaactg cctggcttga                  50


<210> 29
<211> 50
<212> DNA
<213> Prevotella copri


<220>
<221> modified_base
<222> (9)..(10)
<223> a, c, t, g, unknown or other

<400> 29
gaaatgtann cgctcaacgt ctgcactgca gcgcgaactg gtttccttga                  50


<210> 30
<211> 50
<212> DNA
<213> Prevotella copri

<400> 30
gaaaaaccgt cgctcaacga cggccgtgca gcgcgaactg gacgccttga                  50


<210> 31
<211> 50
<212> DNA
<213> Prevotella copri


<220>
<221> modified_base
<222> (5)..(6)
<223> a, c, t, g, unknown or other 

<220>
<221> modified_base
<222> (10)..(10)
<223> a, c, t, g, unknown or other 

<220>
<221> modified_base
<222> (25)..(25)
<223> a, c, t, g, unknown or other 

<220>
<221> modified_base
<222> (44)..(44)
<223> a, c, t, g, unknown or other 

<400> 31
gaaanntagn cgctcaacgt ctgcnctgca gcgcgaactg gttnccttga                  50


<210> 32
<211> 50
<212> DNA
<213> Prevotella copri

<400> 32
gtacgcacaa agtgggcgga attcgtggtg tagcggtgaa atgcttagat                  50


<210> 33
<211> 50
<212> DNA
<213> Prevotella copri

<400> 33
gtgtgcgcaa cgttggcgga attcgtcgtg tagcggtgaa atgcttagat                  50


<210> 34
<211> 50
<212> DNA
<213> Prevotella copri

<400> 34
gtacgcacaa agtgggcgga attcgtggtg tagcggtgaa atgcttagat                  50


<210> 35
<211> 50
<212> DNA
<213> Prevotella copri

<400> 35
gtgcgctgaa agtgggcgga atttgtggtg tagcggtgaa atgcttagat                  50


<210> 36
<211> 50
<212> DNA
<213> Prevotella copri 

<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other 

<400> 36
gtncgcacaa agtgggcgga attcgtggtg tagcggtgaa atgcttagat                  50


<210> 37
<211> 14
<212> PRT
<213> Homo sapiens

<400> 37
Phe Glu Pro Phe Phe Met Met Ile Ala Thr Pro Ala Pro His 
1               5                   10                  


<210> 38
<211> 12
<212> PRT
<213> Prevotella sp.

<400> 38
Pro Phe Phe Met Met Val Ala Met Asn Pro Pro His 
1               5                   10          


<210> 39
<211> 12
<212> PRT
<213> Parabacteroides sp.

<400> 39
Pro Phe Phe Met Met Trp Thr Thr Pro Leu Pro His 
1               5                   10          


<210> 40
<211> 15
<212> PRT
<213> Homo sapiens

<400> 40
Asn Pro Ala Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly 
1               5                   10                  15  


<210> 41
<211> 10
<212> PRT
<213> Prevotella sp.

<400> 41
Phe Val Val Lys Thr Ala Asn Ala Gly Ala 
1               5                   10  


<210> 42
<211> 10
<212> PRT
<213> Butyricimonas sp.

<400> 42
Phe Met Ile Asn Val Ser Asn Ala Gly Ala 
1               5                   10  


<210> 43
<211> 14
<212> PRT
<213> Homo sapiens

<400> 43
Phe Glu Pro Phe Phe Met Met Ile Ala Thr Pro Ala Pro His 
1               5                   10                  


<210> 44
<211> 14
<212> PRT
<213> Homo sapiens

<400> 44
Phe Glu Pro Phe Phe Met Met Ile Ala Thr Pro Ala Pro His 
1               5                   10                  


<210> 45
<211> 15
<212> PRT
<213> Homo sapiens

<400> 45
Asn Pro Ala Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly 
1               5                   10                  15  


<210> 46
<211> 15
<212> PRT
<213> Homo sapiens

<400> 46
Asn Pro Ala Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly 
1               5                   10                  15  


