                               SEQUENCE LISTING

<110> TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER 
      EDUCATION
 
<120> RNA GUIDED COMPOSITIONS FOR PREVENTING AND TREATING HEPATITIS B 
      VIRUS INFECTIONS

<130> 4941I.033

<140> PCT/US2017/034773
<141> 2017-05-26

<150> 62/474,912
<151> 2017-03-22

<150> 62/346,859
<151> 2016-06-07

<160> 38    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
caagaatcct cacaataccg                                                   20


<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
caaaaatcct cacaataccg                                                   20


<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
caagaatcct cacaatacca                                                   20


<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
caaaaatcct cacaatacca                                                   20


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
ttgtctacgt cccgtcagcg                                                   20


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
ttgtttacgt cccgtcagcg                                                   20


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ttgtttacgt cccgtcggcg                                                   20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
ttgtctacgt cccgtcggcg                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
tagacaaagg acgttccgcg                                                   20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
tagacaaagg acgctcctcg                                                   20


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
tagacaaagg acgctccccg                                                   20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
taaacaaagg acgctccccg                                                   20


<210> 13
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
caagaatcct cacaatac                                                     18


<210> 14
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
gtattgtgag gattcttg                                                     18


<210> 15
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
ggacgtcctt tgtttacg                                                     18


<210> 16
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
cgtaaacaaa ggacgtcc                                                     18


<210> 17
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
gtcctttgtt tacgtcccgt cggcg                                             25


<210> 18
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
cgccgacggg acgtaaacaa aggac                                             25


<210> 19
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
tccagttcag gagcagtaaa cc                                                22


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
agaaggggac gagagagtct c                                                 21


<210> 21
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
tcaccagcac catgcaac                                                     18


<210> 22
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
aagccaccca aggcacag                                                     18


<210> 23
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
gagtgtggat tcgcactcc                                                    19


<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
gaggcgaggg agttcttct                                                    19


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
cccttggacc cagaggttct                                                   20


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
cgagcacttt cttgccatga                                                   20


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
ctacaatgag ctgcgtgtgg c                                                 21


<210> 28
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
caggtccaga cgcaggatgg c                                                 21


<210> 29
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
ctcgccaaca agttgacgag ataa                                              24


<210> 30
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
ctatctagag agagggccta tttcccatg                                         29


<210> 31
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
atctctagat tgtggaaagg acgaaacacc taggcagagg tgaaaaagtt gcatggtttg       60

gaccatgcaa ctttttcacc tctgcctatt tttttactag tatc                       104


<210> 32
<211> 1888
<212> DNA
<213> Hepatitis B virus


<220>
<221> modified_base
<222> (26)..(151)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (185)..(1684)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1736)..(1864)
<223> a, c, t, g, unknown or other

<400> 32
tccagttcag gagcagtaaa ccctgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntgacaagaa tcctcacaat accgcagagt      180

ctagnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      300

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      360

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      420

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      480

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      540

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      600

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      660

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      720

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      780

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      840

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      900

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      960

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1020

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1080

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1140

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1200

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1260

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1320

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1380

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1440

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1500

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1560

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1620

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1680

nnnntggatc ctgcgcggga cgtcctttgt ttacgtcccg tcggcgctga atcctnnnnn     1740

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1800

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1860

nnnngtgcac ttcgcttcac ctctgcac                                        1888


<210> 33
<211> 171
<212> DNA
<213> Hepatitis B virus


<220>
<221> modified_base
<222> (26)..(151)
<223> a, c, t, g, unknown or other

<400> 33
tccagttcag gagcagtaaa ccctgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntgacaagaa tcctcacaat a               171


<210> 34
<211> 192
<212> DNA
<213> Hepatitis B virus


<220>
<221> modified_base
<222> (40)..(168)
<223> a, c, t, g, unknown or other

<400> 34
gggacgtcct ttgtttacgt cccgtcggcg ctgaatcctn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnngt gcacttcgct      180

tcacctctgc ac                                                          192


<210> 35
<211> 171
<212> DNA
<213> Hepatitis B virus


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (8)..(9)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (26)..(151)
<223> a, c, t, g, unknown or other

<400> 35
tccngttnng gagcagtaaa ccctgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntgacaagaa tcctcacaat a               171


<210> 36
<211> 192
<212> DNA
<213> Hepatitis B virus


<220>
<221> modified_base
<222> (40)..(168)
<223> a, c, t, g, unknown or other

<400> 36
gggacgtcct ttgtttacgt cccgtcggcg ctgaatcctn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnngt gcacttcgct      180

tcacctctgc ac                                                          192


<210> 37
<211> 171
<212> DNA
<213> Hepatitis B virus


<220>
<221> modified_base
<222> (26)..(151)
<223> a, c, t, g, unknown or other

<400> 37
tccagttcag gagcagtaaa ccctgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntgacaagaa tcctcacaat a               171


<210> 38
<211> 193
<212> DNA
<213> Hepatitis B virus


<220>
<221> modified_base
<222> (41)..(169)
<223> a, c, t, g, unknown or other

<400> 38
tgggacgtcc tttgtttacg tcccgtcggc gctgaatcct nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng tgcacttcgc      180

ttcacctctg cac                                                         193



