                         SEQUENCE LISTING

<110>  VERITAS BIOTECNOLOGIA LTDA
 
<120>  NOVEL MONOCLONAL ANTIBODIES PREVENT CELL SURFACE PROTEIN SHEDDING
        AND BLOCK TUMOR GROWTH

<130>  11170.003

<150>  62/348,347
<151>  2016-06-10

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  1

Val Glu Ala Gly Leu Gln Ile Pro Ala 
1               5                   


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  2

Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro Ala 
1               5                   10                  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  3

Val Glu Ala Gly Leu Gln Ile Pro Ala Cys 
1               5                   10  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  4

Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro Ala Cys 
1               5                   10                  15  


<210>  5
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  5

Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro Ala Ile Leu Gly 
1               5                   10                  15      


Ile Leu Gly Gly Ile Leu Ala Leu Leu Ile Leu Ile Leu Leu Leu Leu 
            20                  25                  30          


Leu Phe 
        


<210>  6
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  6

Pro Gly Gln Glu Ala Gly Leu Gly Gln Val Pro Leu Ile Val Gly Ile 
1               5                   10                  15      


Leu Leu Val Leu Met Ala Val Val Leu Ala Ser Leu Ile 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  7

Thr Thr Ser Gly Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile 
1               5                   10                  15      


Ile Leu Ala Ser Leu Leu Ala Leu Ala Leu Ile Leu Ala 
            20                  25                  


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  8

Met Ala Ala Ser Leu Ser Pro Gly Ala Leu Ile Ala Leu Leu Val Cys 
1               5                   10                  15      


Val Leu Ile Leu Val Val Leu Val Leu Leu Ile Leu Thr Leu Arg 
            20                  25                  30      


<210>  9
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  9

Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
1               5                   10                  15      


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg 
            20                  25                  30  


<210>  10
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  10

Pro Pro Glu Pro Ser Val Pro Leu Leu Pro Leu Leu Val Ala Gly Ala 
1               5                   10                  15      


Val Leu Leu Leu Val Ile Leu Val Leu Gly Val Met Val Ala Arg Arg 
            20                  25                  30          


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  11

Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val 
1               5                   10                  15      


Leu Leu Gly Ala Val Ile Thr 
            20              


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  12

Pro Met Arg Trp Pro Phe Phe Leu Phe Ile Pro Phe Phe Ile Ile Phe 
1               5                   10                  15      


Cys Val Leu Ile Ala Ile Met 
            20              


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  13

Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu Val Ala Gly 
1               5                   10                  15      


Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys 
            20                  25      


<210>  14
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker segment

<400>  15

Arg Lys Ala Gln Pro Val Glu Ala Gly Leu Gln Ile Pro Ala Ile 
1               5                   10                  15  


