                         SEQUENCE LISTING

<110>  Universit del Piemonte Orientale
 
<120>  Promoter for Cell-Specific Gene Expression and Uses thereof

<130>  21.U0064.12.WO.1

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  1175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LV.pF8.1

<400>  1
gagctcacca tggctacatt ctgatgtaaa gagatatatc ctatacctgg gccaaatgta       60

aacagcctgg aaaagtgtta ggttaaaaac aaaacaaaat aaataaatga ataaatgcca      120

ggtggttatg agtgctattg agaaaaatga agccaagagg gatatcagtg atgcaggtgg      180

gggtaaagag cttacaacat aaatgtggtg ttccatattt aaacctcatt caacagggaa      240

gattggagct gaaatgtgaa ggagttgtgg gagtggaact acgtggaaat ctgggggaaa      300

ggtgttttgg gtaaaagaaa tagcaagtgt tgaggtccag gggcatgagt gtgcttgata      360

ttttagggaa gagtaaggag accagtataa ccagagtgag atgagactac agaggtcagg      420

agaaagggca tgcagaccat gtgggatgct ctaggaccta ggccatggta aagatgtagg      480

gttttaccct gatggaggtc agaagccatt ggaggattct gagaagagga gtgacaggac      540

tcgctttata gttttaaatt ataactataa attatagttt ttaaaacaat agttgcctaa      600

cctcatgtta tatgtaaaac tacagtttta aaaactataa attcctcata ctggcagcag      660

tgtgaggggc aagggcaaaa gcagagagac taacaggttg ctggttactc ttgctagtgc      720

aagtgaattc tagaatcttc gacaacatcc agaacttctc ttgctgctgc cactcaggaa      780

gagggttgga gtaggctagg aataggagca caaattaaag ctcctgttca ctttgacttc      840

tccatccctc tcctcctttc cttaaaggtt ctgattaaag cagacttatg cccctactgc      900

tctcagaagt gaatgggtta agtttagcag cctccctttt gctacttcag ttcttcctgt      960

ggctgcttcc cactgataaa aaggaagcaa tcctatcggt tactgcttag tgctgagcac     1020

atccagtggg taaagttcct taaaatgctc tgcaaagaaa ttgggacttt tcattaaatc     1080

agaaatttta cttttttccc ctcctgggag ctaaagatat tttagagaag aattaacctt     1140

ttgcttctcc agttgaacat ttgtagcaat aagtc                                1175


<210>  2
<211>  599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LV.pF8.2

<400>  2
gtttttaaaa caatagttgc ctaacctcat gttatatgta aaactacagt tttaaaaact       60

ataaattcct catactggca gcagtgtgag gggcaagggc aaaagcagag agactaacag      120

gttgctggtt actcttgcta gtgcaagtga attctagaat cttcgacaac atccagaact      180

tctcttgctg ctgccactca ggaagagggt tggagtaggc taggaatagg agcacaaatt      240

aaagctcctg ttcactttga cttctccatc cctctcctcc tttccttaaa ggttctgatt      300

aaagcagact tatgccccta ctgctctcag aagtgaatgg gttaagttta gcagcctccc      360

ttttgctact tcagttcttc ctgtggctgc ttcccactga taaaaaggaa gcaatcctat      420

cggttactgc ttagtgctga gcacatccag tgggtaaagt tccttaaaat gctctgcaaa      480

gaaattggga cttttcatta aatcagaaat tttacttttt tcccctcctg ggagctaaag      540

atattttaga gaagaattaa ccttttgctt ctccagttga acatttgtag caataagtc       599


<210>  3
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LV.pF8.3

<400>  3
ggggctcgct cgctcagtac ctggaggcga gttcctgacg cgactgcgac tcaatcctcg       60

cctggtgaag aatattttac ctatgactca ctgaaaataa agacggctga gtgaccgtgt      120

ttgttcatgt aaacattgaa caaatattta tcggcttctg cgatgtgtcc tactctttta      180

gtggaggaag acacatttta tttatgtatt taatttttct tttgaatttt acatgcgagt      240

tatacttaat aaaactcact tcaaaatata ccttcaacag aaaatccagc aacagtttct      300

attatgttag ttaaaacagc cagtcttttc ctttactttt aaaaattatt cataaatgta      360

attagtgaat gataataaac attgacatct gatccactgc tttaggagtg acacaaatga      420

agttaactca ggctattttc tttataatca ttgtgctatt gttttctttt tcttttcaat      480

tatactgctt aatataggat tttgtggcac cataggagtt gaggagctca ccatggctac      540

attctgatgt aaagagatat atcctatacc tgggccaaat gtaaacagcc tggaaaagtg      600

ttaggttaaa aacaaaacaa aataaataaa tgaataaatg ccaggtggtt atgagtgcta      660

ttgagaaaaa tgaagccaag agggatatca gtgatgcagg tgggggtaaa gagcttacaa      720

cataaatgtg gtgttccata tttaaacctc attcaacagg gaagattgga gctgaaatgt      780

gaaggagttg tgggagtgga actacgtgga aatctggggg aaaggtgttt tgggtaaaag      840

aaatagcaag tgttgaggtc caggggcatg agtgtgcttg atattttagg gaagagtaag      900

gagaccagta taaccagagt gagatgagac tacagaggtc aggagaaagg gcatgcagac      960

catgtgggat gctctaggac ctaggccatg gtaaagatgt agggttttac cctgatggag     1020

gtcagaagcc attggaggat tctgagaaga ggagtgacag gactcgcttt atagttttaa     1080

attataacta taaattatag tttttaaaac aatagttgcc taacctcatg ttatatgtaa     1140

aactacagtt ttaaaaacta taaattcctc atactggcag cagtgtgagg ggcaagggca     1200

aaagcagaga gactaacagg ttgctggtta ctcttgctag tgcaagtgaa ttctagaatc     1260

ttcgacaaca tccagaactt ctcttgctgc tgccactcag gaagagggtt ggagtaggct     1320

aggaatagga gcacaaatta aagctcctgt tcactttgac ttctccatcc ctctcctcct     1380

ttccttaaag gttctgatta aagcagactt atgcccctac tgctctcaga agtgaatggg     1440

ttaagtttag cagcctccct tttgctactt cagttcttcc tgtggctgct tcccactgat     1500

aaaaaggaag caatcctatc ggttactgct tagtgctgag cacatccagt gggtaaagtt     1560

ccttaaaatg ctctgcaaag aaattgggac ttttcattaa atcagaaatt ttactttttt     1620

cccctcctgg gagctaaaga tattttagag aagaattaac cttttgcttc tccagttgaa     1680

catttgtagc aataagtc                                                   1698


<210>  4
<211>  1122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LV.pF8.4

<400>  4
ggggctcgct cgctcagtac ctggaggcga gttcctgacg cgactgcgac tcaatcctcg       60

cctggtgaag aatattttac ctatgactca ctgaaaataa agacggctga gtgaccgtgt      120

ttgttcatgt aaacattgaa caaatattta tcggcttctg cgatgtgtcc tactctttta      180

gtggaggaag acacatttta tttatgtatt taatttttct tttgaatttt acatgcgagt      240

tatacttaat aaaactcact tcaaaatata ccttcaacag aaaatccagc aacagtttct      300

attatgttag ttaaaacagc cagtcttttc ctttactttt aaaaattatt cataaatgta      360

attagtgaat gataataaac attgacatct gatccactgc tttaggagtg acacaaatga      420

agttaactca ggctattttc tttataatca ttgtgctatt gttttctttt tcttttcaat      480

tatactgctt aatataggat tttgtggcac cataggagtt gaggttttta aaacaatagt      540

tgcctaacct catgttatat gtaaaactac agttttaaaa actataaatt cctcatactg      600

gcagcagtgt gaggggcaag ggcaaaagca gagagactaa caggttgctg gttactcttg      660

ctagtgcaag tgaattctag aatcttcgac aacatccaga acttctcttg ctgctgccac      720

tcaggaagag ggttggagta ggctaggaat aggagcacaa attaaagctc ctgttcactt      780

tgacttctcc atccctctcc tcctttcctt aaaggttctg attaaagcag acttatgccc      840

ctactgctct cagaagtgaa tgggttaagt ttagcagcct cccttttgct acttcagttc      900

ttcctgtggc tgcttcccac tgataaaaag gaagcaatcc tatcggttac tgcttagtgc      960

tgagcacatc cagtgggtaa agttccttaa aatgctctgc aaagaaattg ggacttttca     1020

ttaaatcaga aattttactt ttttcccctc ctgggagcta aagatatttt agagaagaat     1080

taaccttttg cttctccagt tgaacatttg tagcaataag tc                        1122


<210>  5
<211>  1979
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LV.pF8.5

<400>  5
tcgccaccac ttggcttccg gcacgtgggg cagatgtttc cattcccacg gcggcagcgg       60

aagagggagg gccgggcgcg ccgcggctgc ttgcagtctc cgcaagcggc tacatcacag      120

agctcagcgt gcggtgtcac aggccccgcg gtcccgccca acagatgcac cgagatgcgc      180

gtgcgcagaa agcgtcccgg gggtgaggct ccctccctcg ctctccctct actcccgccc      240

cactctcccc cactttcccc cctccaccca ccgcggccgt cggggctcgc tcgctcagta      300

cctggaggcg agttcctgac gcgactgcga ctcaatcctc gcctggtgaa gaatatttta      360

cctatgactc actgaaaata aagacggctg agtgaccgtg tttgttcatg taaacattga      420

acaaatattt atcggcttct gcgatgtgtc ctactctttt agtggaggaa gacacatttt      480

atttatgtat ttaatttttc ttttgaattt tacatgcgag ttatacttaa taaaactcac      540

ttcaaaatat accttcaaca gaaaatccag caacagtttc tattatgtta gttaaaacag      600

ccagtctttt cctttacttt taaaaattat tcataaatgt aattagtgaa tgataataaa      660

cattgacatc tgatccactg ctttaggagt gacacaaatg aagttaactc aggctatttt      720

ctttataatc attgtgctat tgttttcttt ttcttttcaa ttatactgct taatatagga      780

ttttgtggca ccataggagt tgaggagctc accatggcta cattctgatg taaagagata      840

tatcctatac ctgggccaaa tgtaaacagc ctggaaaagt gttaggttaa aaacaaaaca      900

aaataaataa atgaataaat gccaggtggt tatgagtgct attgagaaaa atgaagccaa      960

gagggatatc agtgatgcag gtgggggtaa agagcttaca acataaatgt ggtgttccat     1020

atttaaacct cattcaacag ggaagattgg agctgaaatg tgaaggagtt gtgggagtgg     1080

aactacgtgg aaatctgggg gaaaggtgtt ttgggtaaaa gaaatagcaa gtgttgaggt     1140

ccaggggcat gagtgtgctt gatattttag ggaagagtaa ggagaccagt ataaccagag     1200

tgagatgaga ctacagaggt caggagaaag ggcatgcaga ccatgtggga tgctctagga     1260

cctaggccat ggtaaagatg tagggtttta ccctgatgga ggtcagaagc cattggagga     1320

ttctgagaag aggagtgaca ggactcgctt tatagtttta aattataact ataaattata     1380

gtttttaaaa caatagttgc ctaacctcat gttatatgta aaactacagt tttaaaaact     1440

ataaattcct catactggca gcagtgtgag gggcaagggc aaaagcagag agactaacag     1500

gttgctggtt actcttgcta gtgcaagtga attctagaat cttcgacaac atccagaact     1560

tctcttgctg ctgccactca ggaagagggt tggagtaggc taggaatagg agcacaaatt     1620

aaagctcctg ttcactttga cttctccatc cctctcctcc tttccttaaa ggttctgatt     1680

aaagcagact tatgccccta ctgctctcag aagtgaatgg gttaagttta gcagcctccc     1740

ttttgctact tcagttcttc ctgtggctgc ttcccactga taaaaaggaa gcaatcctat     1800

cggttactgc ttagtgctga gcacatccag tgggtaaagt tccttaaaat gctctgcaaa     1860

gaaattggga cttttcatta aatcagaaat tttacttttt tcccctcctg ggagctaaag     1920

atattttaga gaagaattaa ccttttgctt ctccagttga acatttgtag caataagtc      1979


<210>  6
<211>  1403
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LV.pF8.6

<400>  6
tcgccaccac ttggcttccg gcacgtgggg cagatgtttc cattcccacg gcggcagcgg       60

aagagggagg gccgggcgcg ccgcggctgc ttgcagtctc cgcaagcggc tacatcacag      120

agctcagcgt gcggtgtcac aggccccgcg gtcccgccca acagatgcac cgagatgcgc      180

gtgcgcagaa agcgtcccgg gggtgaggct ccctccctcg ctctccctct actcccgccc      240

cactctcccc cactttcccc cctccaccca ccgcggccgt cggggctcgc tcgctcagta      300

cctggaggcg agttcctgac gcgactgcga ctcaatcctc gcctggtgaa gaatatttta      360

cctatgactc actgaaaata aagacggctg agtgaccgtg tttgttcatg taaacattga      420

acaaatattt atcggcttct gcgatgtgtc ctactctttt agtggaggaa gacacatttt      480

atttatgtat ttaatttttc ttttgaattt tacatgcgag ttatacttaa taaaactcac      540

ttcaaaatat accttcaaca gaaaatccag caacagtttc tattatgtta gttaaaacag      600

ccagtctttt cctttacttt taaaaattat tcataaatgt aattagtgaa tgataataaa      660

cattgacatc tgatccactg ctttaggagt gacacaaatg aagttaactc aggctatttt      720

ctttataatc attgtgctat tgttttcttt ttcttttcaa ttatactgct taatatagga      780

ttttgtggca ccataggagt tgaggttttt aaaacaatag ttgcctaacc tcatgttata      840

tgtaaaacta cagttttaaa aactataaat tcctcatact ggcagcagtg tgaggggcaa      900

gggcaaaagc agagagacta acaggttgct ggttactctt gctagtgcaa gtgaattcta      960

gaatcttcga caacatccag aacttctctt gctgctgcca ctcaggaaga gggttggagt     1020

aggctaggaa taggagcaca aattaaagct cctgttcact ttgacttctc catccctctc     1080

ctcctttcct taaaggttct gattaaagca gacttatgcc cctactgctc tcagaagtga     1140

atgggttaag tttagcagcc tcccttttgc tacttcagtt cttcctgtgg ctgcttccca     1200

ctgataaaaa ggaagcaatc ctatcggtta ctgcttagtg ctgagcacat ccagtgggta     1260

aagttcctta aaatgctctg caaagaaatt gggacttttc attaaatcag aaattttact     1320

tttttcccct cctgggagct aaagatattt tagagaagaa ttaacctttt gcttctccag     1380

ttgaacattt gtagcaataa gtc                                             1403


<210>  7
<211>  2350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  0 to 2350 5' FVIII promoter sequence

<400>  7
cagcagttcc cacaaacgtt accctcacaa tgaatccagc catttttcac cctctccagt       60

ggtaccatca tagcccaagc cgccaccatt tctcaccccc ggttaacagg ccaccctcct      120

tctaccctta tcctgctaga gtttgtttta tctacagtga tcagaaagat cagcctaaaa      180

gataattctg atcaccaccc tcctctactc acaacccggc cgtgtctccc cattgccctc      240

agtgtagaag tcaatgtccc tttgctgaaa tgcaacctta gtgaaacttt ccatgactaa      300

cctcctttaa aattgcaacc tggtccaccc ttactccccc ttaccccact tctctttttt      360

gcacagcact tattttacct tctaacatac tgtataatgt actcatgtat tgtaattatt      420

gcttatcatc cctctttcag ttgcttatat ttttcatcaa tgtgtaccca gtgcctagga      480

caatatctgt ctaggacaaa tgggtagtta tgtggctgta ggcaagccat ttaacctctc      540

tgtacctcag ttactttatc tgtatccact ttgcggtgtt gtcatgagga ttaaatcaga      600

tagcctatgt gtagcacctg gcagtgaatt tatcaccctg tactgtaact gtctactttt      660

ctgtctcctc cattggactg tcattcccag ggggttggga actgggattt cttcatttct      720

gaggcataga agtatagcat agtggttagg agcatgactt ctggagccag agtacatggg      780

tttgaatgct accactcaca agctgtgtgg ccatggagaa gttgcctaac ctctccgtgc      840

ttcagtttca tcacccataa aatgaaggta agaatagtac ctgtatttaa aagcacctag      900

aacagttcct ggcatatagt gtcagctgtc atctctgcat ccttgtacct gtcagagagg      960

agtgtttatc aaaggggctt cttgctgcct gtttccaaac cagtcgacaa tataccaatt     1020

gctccctaac acattcttgt ttgtgcagaa ctgagctcaa tgataacatt tttatagcaa     1080

ccctgatcaa gtttcttctc ataatctctt acactttgag gcccctgcag gggccctcac     1140

tctccctaat aaacattaac ctgagtaggg tgtttgagct caccatggct acattctgat     1200

gtaaagagat atatcctata cctgggccaa atgtaaacag cctggaaaag tgttaggtta     1260

aaaacaaaac aaaataaata aatgaataaa tgccaggtgg ttatgagtgc tattgagaaa     1320

aatgaagcca agagggatat cagtgatgca ggtgggggta aagagcttac aacataaatg     1380

tggtgttcca tatttaaacc tcattcaaca gggaagattg gagctgaaat gtgaaggagt     1440

tgtgggagtg gaactacgtg gaaatctggg ggaaaggtgt tttgggtaaa agaaatagca     1500

agtgttgagg tccaggggca tgagtgtgct tgatatttta gggaagagta aggagaccag     1560

tataaccaga gtgagatgag actacagagg tcaggagaaa gggcatgcag accatgtggg     1620

atgctctagg acctaggcca tggtaaagat gtagggtttt accctgatgg aggtcagaag     1680

ccattggagg attctgagaa gaggagtgac aggactcgct ttatagtttt aaattataac     1740

tataaattat agtttttaaa acaatagttg cctaacctca tgttatatgt aaaactacag     1800

ttttaaaaac tataaattcc tcatactggc agcagtgtga ggggcaaggg caaaagcaga     1860

gagactaaca ggttgctggt tactcttgct agtgcaagtg aattctagaa tcttcgacaa     1920

catccagaac ttctcttgct gctgccactc aggaagaggg ttggagtagg ctaggaatag     1980

gagcacaaat taaagctcct gttcactttg acttctccat ccctctcctc ctttccttaa     2040

aggttctgat taaagcagac ttatgcccct actgctctca gaagtgaatg ggttaagttt     2100

agcagcctcc cttttgctac ttcagttctt cctgtggctg cttcccactg ataaaaagga     2160

agcaatccta tcggttactg cttagtgctg agcacatcca gtgggtaaag ttccttaaaa     2220

tgctctgcaa agaaattggg acttttcatt aaatcagaaa ttttactttt ttcccctcct     2280

gggagctaaa gatattttag agaagaatta accttttgct tctccagttg aacatttgta     2340

gcaataagtc                                                            2350


<210>  8
<211>  523
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer Short

<400>  8
ggggctcgct cgctcagtac ctggaggcga gttcctgacg cgactgcgac tcaatcctcg       60

cctggtgaag aatattttac ctatgactca ctgaaaataa agacggctga gtgaccgtgt      120

ttgttcatgt aaacattgaa caaatattta tcggcttctg cgatgtgtcc tactctttta      180

gtggaggaag acacatttta tttatgtatt taatttttct tttgaatttt acatgcgagt      240

tatacttaat aaaactcact tcaaaatata ccttcaacag aaaatccagc aacagtttct      300

attatgttag ttaaaacagc cagtcttttc ctttactttt aaaaattatt cataaatgta      360

attagtgaat gataataaac attgacatct gatccactgc tttaggagtg acacaaatga      420

agttaactca ggctattttc tttataatca ttgtgctatt gttttctttt tcttttcaat      480

tatactgctt aatataggat tttgtggcac cataggagtt gag                        523


<210>  9
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Enhancer Long

<400>  9
tcgccaccac ttggcttccg gcacgtgggg cagatgtttc cattcccacg gcggcagcgg       60

aagagggagg gccgggcgcg ccgcggctgc ttgcagtctc cgcaagcggc tacatcacag      120

agctcagcgt gcggtgtcac aggccccgcg gtcccgccca acagatgcac cgagatgcgc      180

gtgcgcagaa agcgtcccgg gggtgaggct ccctccctcg ctctccctct actcccgccc      240

cactctcccc cactttcccc cctccaccca ccgcggccgt cggggctcgc tcgctcagta      300

cctggaggcg agttcctgac gcgactgcga ctcaatcctc gcctggtgaa gaatatttta      360

cctatgactc actgaaaata aagacggctg agtgaccgtg tttgttcatg taaacattga      420

acaaatattt atcggcttct gcgatgtgtc ctactctttt agtggaggaa gacacatttt      480

atttatgtat ttaatttttc ttttgaattt tacatgcgag ttatacttaa taaaactcac      540

ttcaaaatat accttcaaca gaaaatccag caacagtttc tattatgtta gttaaaacag      600

ccagtctttt cctttacttt taaaaattat tcataaatgt aattagtgaa tgataataaa      660

cattgacatc tgatccactg ctttaggagt gacacaaatg aagttaactc aggctatttt      720

ctttataatc attgtgctat tgttttcttt ttcttttcaa ttatactgct taatatagga      780

ttttgtggca ccataggagt tgag                                             804


<210>  10
<211>  4429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full 5' FVIII promoter sequence

<400>  10
tcgccaccac ttggcttccg gcacgtgggg cagatgtttc cattcccacg gcggcagcgg       60

aagagggagg gccgggcgcg ccgcggctgc ttgcagtctc cgcaagcggc tacatcacag      120

agctcagcgt gcggtgtcac aggccccgcg gtcccgccca acagatgcac cgagatgcgc      180

gtgcgcagaa agcgtcccgg gggtgaggct ccctccctcg ctctccctct actcccgccc      240

cactctcccc cactttcccc cctccaccca ccgcggccgt cggggctcgc tcgctcagta      300

cctggaggcg agttcctgac gcgactgcga ctcaatcctc gcctggtgaa gaatatttta      360

cctatgactc actgaaaata aagacggctg agtgaccgtg tttgttcatg taaacattga      420

acaaatattt atcggcttct gcgatgtgtc ctactctttt agtggaggaa gacacatttt      480

atttatgtat ttaatttttc ttttgaattt tacatgcgag ttatacttaa taaaactcac      540

ttcaaaatat accttcaaca gaaaatccag caacagtttc tattatgtta gttaaaacag      600

ccagtctttt cctttacttt taaaaattat tcataaatgt aattagtgaa tgataataaa      660

cattgacatc tgatccactg ctttaggagt gacacaaatg aagttaactc aggctatttt      720

ctttataatc attgtgctat tgttttcttt ttcttttcaa ttatactgct taatatagga      780

ttttgtggca ccataggagt tgagtaaaaa taaaaggaat aaaaatatac cttatctggc      840

cgggcgcggt ggctcacgcc tgtaatttca gcagtttcgg aggccgaggc gggcggatca      900

cgcggtcagg agatcgaggc catcctggct aacatggtga aaccccgtct ctactaaaaa      960

tacaaaaaat tagccgggca tggtggcggc cgcctgtagt cccagctact cgggaggctg     1020

aggcaggaga atggcgtgaa cccgggaggc ggagcttgca gtgagccgag atcgcgacac     1080

tgcactccag cctgggcgac agagtgagac tgcgtctcca aaaaaaaaag aaaaaatacg     1140

ttatctatga agatttccaa tttgatttct atttatcaca aatggccaca gtactccttt     1200

gtactttacc acataccata ttgtattcag taattatttg tgaatatgta attgataata     1260

ttgtaggttt tagagaatcc ttgaaaacat gaaaatttgg taatggggtc tattttgatt     1320

atttatttat ttatttattt attttatttt tgagacagag tctcgctctt gttgcccagg     1380

ctggagtgca gtggcgcgat ctcggctcac tgcaagctcc acctcccggg ttcaagcgat     1440

tctcctgcct cagcctccca agtagctggg actacaggca cgtgccacca tgcccggcta     1500

attttttgta tttttagtag aggaggagtt tcatcttgtt agctaggatg gtctagatct     1560

cctgacctcg tgatctgccc gcctcagcct cccaaagtgc tgggattaca ggtgtgagcc     1620

accgtgcccg gccatatttt gatttaaaat ttagcaataa tagataaaat tttcaatcaa     1680

ctaagccctt gggccaggga atgctattcc ttaaaaagtg cttctatcaa tatagcctct     1740

gactcattac tttgttaatt tttaaattgt atttcattcc tgattaacat tcccacccag     1800

attattaatt atacaatctg ttaactgtag aacctcaaac atgttggatt gtactgtatt     1860

tgtctggaag acacattttt aaaacattgt aatcgctata agagaagcac tgggaaagaa     1920

aggagcttct atgcctgcag tgcctgagga gccctttaac agtgtgcccc gcccctaagc     1980

tactcatgca gtcatcccca tcccagttag tcaactttat tccaaaaaac ttggtgttcc     2040

aaatttttcc ttctcaaagc ccacagatcc aaaattcatc agcagttccc acaaacgtta     2100

ccctcacaat gaatccagcc atttttcacc ctctccagtg gtaccatcat agcccaagcc     2160

gccaccattt ctcacccccg gttaacaggc caccctcctt ctacccttat cctgctagag     2220

tttgttttat ctacagtgat cagaaagatc agcctaaaag ataattctga tcaccaccct     2280

cctctactca caacccggcc gtgtctcccc attgccctca gtgtagaagt caatgtccct     2340

ttgctgaaat gcaaccttag tgaaactttc catgactaac ctcctttaaa attgcaacct     2400

ggtccaccct tactccccct taccccactt ctcttttttg cacagcactt attttacctt     2460

ctaacatact gtataatgta ctcatgtatt gtaattattg cttatcatcc ctctttcagt     2520

tgcttatatt tttcatcaat gtgtacccag tgcctaggac aatatctgtc taggacaaat     2580

gggtagttat gtggctgtag gcaagccatt taacctctct gtacctcagt tactttatct     2640

gtatccactt tgcggtgttg tcatgaggat taaatcagat agcctatgtg tagcacctgg     2700

cagtgaattt atcaccctgt actgtaactg tctacttttc tgtctcctcc attggactgt     2760

cattcccagg gggttgggaa ctgggatttc ttcatttctg aggcatagaa gtatagcata     2820

gtggttagga gcatgacttc tggagccaga gtacatgggt ttgaatgcta ccactcacaa     2880

gctgtgtggc catggagaag ttgcctaacc tctccgtgct tcagtttcat cacccataaa     2940

atgaaggtaa gaatagtacc tgtatttaaa agcacctaga acagttcctg gcatatagtg     3000

tcagctgtca tctctgcatc cttgtacctg tcagagagga gtgtttatca aaggggcttc     3060

ttgctgcctg tttccaaacc agtcgacaat ataccaattg ctccctaaca cattcttgtt     3120

tgtgcagaac tgagctcaat gataacattt ttatagcaac cctgatcaag tttcttctca     3180

taatctctta cactttgagg cccctgcagg ggccctcact ctccctaata aacattaacc     3240

tgagtagggt gtttgagctc accatggcta cattctgatg taaagagata tatcctatac     3300

ctgggccaaa tgtaaacagc ctggaaaagt gttaggttaa aaacaaaaca aaataaataa     3360

atgaataaat gccaggtggt tatgagtgct attgagaaaa atgaagccaa gagggatatc     3420

agtgatgcag gtgggggtaa agagcttaca acataaatgt ggtgttccat atttaaacct     3480

cattcaacag ggaagattgg agctgaaatg tgaaggagtt gtgggagtgg aactacgtgg     3540

aaatctgggg gaaaggtgtt ttgggtaaaa gaaatagcaa gtgttgaggt ccaggggcat     3600

gagtgtgctt gatattttag ggaagagtaa ggagaccagt ataaccagag tgagatgaga     3660

ctacagaggt caggagaaag ggcatgcaga ccatgtggga tgctctagga cctaggccat     3720

ggtaaagatg tagggtttta ccctgatgga ggtcagaagc cattggagga ttctgagaag     3780

aggagtgaca ggactcgctt tatagtttta aattataact ataaattata gtttttaaaa     3840

caatagttgc ctaacctcat gttatatgta aaactacagt tttaaaaact ataaattcct     3900

catactggca gcagtgtgag gggcaagggc aaaagcagag agactaacag gttgctggtt     3960

actcttgcta gtgcaagtga attctagaat cttcgacaac atccagaact tctcttgctg     4020

ctgccactca ggaagagggt tggagtaggc taggaatagg agcacaaatt aaagctcctg     4080

ttcactttga cttctccatc cctctcctcc tttccttaaa ggttctgatt aaagcagact     4140

tatgccccta ctgctctcag aagtgaatgg gttaagttta gcagcctccc ttttgctact     4200

tcagttcttc ctgtggctgc ttcccactga taaaaaggaa gcaatcctat cggttactgc     4260

ttagtgctga gcacatccag tgggtaaagt tccttaaaat gctctgcaaa gaaattggga     4320

cttttcatta aatcagaaat tttacttttt tcccctcctg ggagctaaag atattttaga     4380

gaagaattaa ccttttgctt ctccagttga acatttgtag caataagtc                 4429


<210>  11
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BDD FVIII

<400>  11
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctcccaaa acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt     2340

cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa     2400

gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca     2460

cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca     2520

catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc     2580

caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat     2640

ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc     2700

agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat     2760

cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac     2820

ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg     2880

gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt     2940

ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa     3000

tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg     3060

gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat     3120

tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct     3180

caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct     3240

attcatttca gtggacatgt gttcaccgta cgaaaaaaag aggagtataa aatggcactg     3300

tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt     3360

tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg     3420

gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt     3480

cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat     3540

tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg     3600

ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc     3660

ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat     3720

cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata     3780

aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat     3840

tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc     3900

atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac     3960

tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg     4020

agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag     4080

aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg     4140

tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt     4200

cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac     4260

tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac     4320

cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta ctga           4374


<210>  12
<211>  442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LV.pF8.8

<400>  12
aatcttcgac aacatccaga acttctcttg ctgctgccac tcaggaagag ggttggagta       60

ggctaggaat aggagcacaa attaaagctc ctgttcactt tgacttctcc atccctctcc      120

tcctttcctt aaaggttctg attaaagcag acttatgccc ctactgctct cagaagtgaa      180

tgggttaagt ttagcagcct cccttttgct acttcagttc ttcctgtggc tgcttcccac      240

tgataaaaag gaagcaatcc tatcggttac tgcttagtgc tgagcacatc cagtgggtaa      300

agttccttaa aatgctctgc aaagaaattg ggacttttca ttaaatcaga aattttactt      360

ttttcccctc ctgggagcta aagatatttt agagaagaat taaccttttg cttctccagt      420

tgaacatttg tagcaataag tc                                               442


<210>  13
<211>  4785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-N6

<400>  13
atgcaaagtg atctcggtga gctgcctgtg gacgcaagat ttcctcctag agtgccaaaa       60

tcttttccat tcaacacctc agtcgtgtac aaaaagactc tgtttgtaga attcacggat      120

caccttttca acatcgctaa gccaaggcca ccctggatgg gtctgctagg tcctaccatc      180

caggctgagg tttatgatac agtggtcatt acacttaaga acatggcttc ccatcctgtc      240

agtcttcatg ctgttggtgt atcctactgg aaagcttctg agggagctga atatgatgat      300

cagaccagtc aaagggagaa agaagatgat aaagtcttcc ctggtggaag ccatacatat      360

gtctggcagg tcctgaaaga gaatggtcca atggcctctg acccactgtg ccttacctac      420

tcatatcttt ctcatgtgga cctggtaaaa gacttgaatt caggcctcat tggagcccta      480

ctagtatgta gagaagggag tctggccaag gaaaagacac agaccttgca caaatttata      540

ctactttttg ctgtatttga tgaagggaaa agttggcact cagaaacaaa gaactccttg      600

atgcaggata gggatgctgc atctgctcgg gcctggccta aaatgcacac agtcaatggt      660

tatgtaaaca ggtctctgcc aggtctgatt ggatgccaca ggaaatcagt ctattggcat      720

gtgattggaa tgggcaccac tcctgaagtg cactcaatat tcctcgaagg tcacacattt      780

cttgtgagga accatcgcca ggcgtccttg gaaatctcgc caataacttt ccttactgct      840

caaacactct tgatggacct tggacagttt ctactgtctt gtcatatctc ttcccaccaa      900

catgatggca tggaagctta tgtcaaagta gacagctgtc cagaggaacc ccaactacga      960

atgaaaaata atgaagaagc ggaagactat gatgatgatc ttactgattc tgaaatggat     1020

gtggtcaggt ttgatgatga caactctcct tcctttatcc aaattcgctc agttgccaag     1080

aagcatccta aaacttgggt acattacatt gctgctgaag aggaggactg ggactatgct     1140

cccttagtcc tcgcccccga tgacagaagt tataaaagtc aatatttgaa caatggccct     1200

cagcggattg gtaggaagta caaaaaagtc cgatttatgg catacacaga tgaaaccttt     1260

aagactcgtg aagctattca gcatgaatca ggaatcttgg gacctttact ttatggggaa     1320

gttggagaca cactgttgat tatatttaag aatcaagcaa gcagaccata taacatctac     1380

cctcacggaa tcactgatgt ccgtcctttg tattcaagga gattaccaaa aggtgtaaaa     1440

catttgaagg attttccaat tctgccagga gaaatattca aatataaatg gacagtgact     1500

gtagaagatg ggccaactaa atcagatcct cggtgcctga cccgctatta ctctagtttc     1560

gttaatatgg agagagatct agcttcagga ctcattggcc ctctcctcat ctgctacaaa     1620

gaatctgtag atcaaagagg aaaccagata atgtcagaca agaggaatgt catcctgttt     1680

tctgtatttg atgagaaccg aagctggtac ctcacagaga atatacaacg ctttctcccc     1740

aatccagctg gagtgcagct tgaggatcca gagttccaag cctccaacat catgcacagc     1800

atcaatggct atgtttttga tagtttgcag ttgtcagttt gtttgcatga ggtggcatac     1860

tggtacattc taagcattgg agcacagact gacttccttt ctgtcttctt ctctggatat     1920

accttcaaac acaaaatggt ctatgaagac acactcaccc tattcccatt ctcaggagaa     1980

actgtcttca tgtcgatgga aaacccaggt ctatggattc tggggtgcca caactcagac     2040

tttcggaaca gaggcatgac cgccttactg aaggtttcta gttgtgacaa gaacactggt     2100

gattattacg aggacagtta tgaagatatt tcagcatact tgctgagtaa aaacaatgcc     2160

attgaaccaa gaagcttctc ccagaattca agacacccta gcactaggca aaagcaattt     2220

aatgccacca caattccaga aaatgacata gagaagactg acccttggtt tgcacacaga     2280

acacctatgc ctaaaataca aaatgtctcc tctagtgatt tgttgatgct cttgcgacag     2340

agtcctactc cacatgggct atccttatct gatctccaag aagccaaata tgagactttt     2400

tctgatgatc catcacctgg agcaatagac agtaataaca gcctgtctga aatgacacac     2460

ttcaggccac agctccatca cagtggggac atggtattta cccctgagtc aggcctccaa     2520

ttaagattaa atgagaaact ggggacaact gcagcaacag agttgaagaa acttgatttc     2580

aaagtttcta gtacatcaaa taatctgatt tcaacaattc catcagacaa tttggcagca     2640

ggtactgata atacaagttc cttaggaccc ccaagtatgc cagttcatta tgatagtcaa     2700

ttagatacca ctctatttgg caaaaagtca tctcccctta ctgagtctgg tggacctctg     2760

agcttgagtg aagaaaataa tgattcaaag ttgttagaat caggtttaat gaatagccaa     2820

gaaagttcat ggggaaaaaa tgtatcgacg cgtagctttc aaaagaaaac acgacactat     2880

tttattgctg cagtggagag gctctgggat tatgggatga gtagctcccc acatgttcta     2940

agaaacaggg ctcagagtgg cagtgtccct cagttcaaga aagttgtttt ccaggaattt     3000

actgatggct cctttactca gcccttatac cgtggagaac taaatgaaca tttgggactc     3060

ctggggccat atataagagc agaagttgaa gataatatca tggtaacttt cagaaatcag     3120

gcctctcgtc cctattcctt ctattctagc cttatttctt atgaggaaga tcagaggcaa     3180

ggagcagaac ctagaaaaaa ctttgtcaag cctaatgaaa ccaaaactta cttttggaaa     3240

gtgcaacatc atatggcacc cactaaagat gagtttgact gcaaagcctg ggcttatttc     3300

tctgatgttg acctggaaaa agatgtgcac tcaggcctga ttggacccct tctggtctgc     3360

cacactaaca cactgaaccc tgctcatggg agacaagtga cagtacagga atttgctctg     3420

tttttcacca tctttgatga gaccaaaagc tggtacttca ctgaaaatat ggaaagaaac     3480

tgcagggctc cctgcaatat ccagatggaa gatcccactt ttaaagagaa ttatcgcttc     3540

catgcaatca atggctacat aatggataca ctacctggct tagtaatggc tcaggatcaa     3600

aggattcgat ggtatctgct cagcatgggc agcaatgaaa acatccattc tattcatttc     3660

agtggacatg tgttcactgt acgaaaaaaa gaggagtata aaatggcact gtacaatctc     3720

tatccaggtg tttttgagac agtggaaatg ttaccatcca aagctggaat ttggcgggtg     3780

gaatgcctta ttggcgagca tctacatgct gggatgagca cactttttct ggtgtacagc     3840

aataagtgtc agactcccct gggaatggct tctggacaca ttagagattt tcagattaca     3900

gcttcaggac aatatggaca gtgggcccca aagctggcca gacttcatta ttccggatca     3960

atcaatgcct ggagcaccaa ggagcccttt tcttggatca aggtggatct gttggcacca     4020

atgattattc acggcatcaa gacccagggt gcccgtcaga agttctccag cctctacatc     4080

tctcagttta tcatcatgta tagtcttgat gggaagaagt ggcagactta tcgaggaaat     4140

tccactggaa ccttaatggt cttctttggc aatgtggatt catctgggat aaaacacaat     4200

atttttaacc ctccaattat tgctcgatac atccgtttgc acccaactca ttatagcatt     4260

cgcagcactc ttcgcatgga gttgatgggc tgtgatttaa atagttgcag catgccattg     4320

ggaatggaga gtaaagcaat atcagatgca cagattactg cttcatccta ctttaccaat     4380

atgtttgcca cctggtctcc ttcaaaagct cgacttcacc tccaagggag gagtaatgcc     4440

tggagacctc aggtgaataa tccaaaagag tggctgcaag tggacttcca gaagacaatg     4500

aaagtcacag gagtaactac tcagggagta aaatctctgc ttaccagcat gtatgtgaag     4560

gagttcctca tctccagcag tcaagatggc catcagtgga ctctcttttt tcagaatggc     4620

aaagtaaagg tttttcaggg aaatcaagac tccttcacac ctgtggtgaa ctctctagac     4680

ccaccgttac tgactcgcta ccttcgaatt cacccccaga gttgggtgca ccagattgcc     4740

ctgaggatgg aggttctggg ctgcgaggca caggacctct actga                     4785


<210>  14
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVIII-RH

<400>  14
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctcccaaa acccaccagt cttgaaacac catcaacggg aaataactcg tactactctt     2340

cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa     2400

gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca     2460

cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca     2520

catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc     2580

caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat     2640

ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc     2700

agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat     2760

cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac     2820

ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg     2880

gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt     2940

ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa     3000

tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg     3060

gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat     3120

tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct     3180

caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct     3240

attcatttca gtggacatgt gttcaccgta cgaaaaaaag aggagtataa aatggcactg     3300

tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt     3360

tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg     3420

gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt     3480

cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat     3540

tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg     3600

ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc     3660

ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat     3720

cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata     3780

aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat     3840

tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc     3900

atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac     3960

tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg     4020

agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag     4080

aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg     4140

tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt     4200

cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac     4260

tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac     4320

cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta ctga           4374


<210>  15
<211>  4377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CodonOptimized (CO) FVIII

<400>  15
atgcagatcg agctgtccac ctgctttttt ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggag ctgtcctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc ccggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gccagccacc ccgtgagcct gcacgccgtg      360

ggcgtgagct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgg      420

gagaaagaag atgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaacagcggc ctgatcggcg ctctgctcgt ctgccgggag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcccaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggcc tgattggctg ccaccggaag agcgtgtact ggcacgtgat cggcatgggc      840

accacacccg aggtgcacag catctttctg gaagggcaca cctttctggt ccggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagctctc accagcacga cggcatggaa     1020

gcctacgtga aggtggactc ttgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcggttcgac     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccccct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac ccgggaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacacactg     1440

ctgatcatct tcaagaacca ggctagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag caggcggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga ggacggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggacctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaacatc cagcggtttc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgactctc tgcagctctc cgtgtgtctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggacaccct gaccctgttc cctttcagcg gcgagacagt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg tccaagaaca acgccatcga accccggagc     2280

ttcagccaga acccccccgt gctgacgcgt caccagcggg agatcacccg gacaaccctg     2340

cagtccgacc aggaagagat cgattacgac gacaccatca gcgtggagat gaagaaagag     2400

gatttcgata tctacgacga ggacgagaac cagagcccca gaagcttcca gaagaaaacc     2460

cggcactact tcattgccgc cgtggagagg ctgtgggact acggcatgag ttctagcccc     2520

cacgtgctgc ggaaccgggc ccagagcggc agcgtgcccc agttcaagaa agtggtgttc     2580

caggaattca cagacggcag cttcacccag cctctgtata gaggcgagct gaacgagcac     2640

ctggggctgc tggggcccta catcagggcc gaagtggagg acaacatcat ggtgaccttc     2700

cggaatcagg ccagcagacc ctactccttc tacagcagcc tgatcagcta cgaagaggac     2760

cagcggcagg gcgccgaacc ccggaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg     2880

gcctacttca gcgacgtgga tctggaaaag gacgtgcact ctggactgat tggcccactc     2940

ctggtctgcc acactaacac cctcaacccc gcccacggcc gccaggtgac cgtgcaggaa     3000

ttcgccctgt tcttcaccat cttcgacgag acaaagtcct ggtacttcac cgagaatatg     3060

gaacggaact gcagagcccc ctgcaacatc cagatggaag atcctacctt caaagagaac     3120

taccggttcc acgccatcaa cggctacatc atggacaccc tgcctggcct ggtgatggcc     3180

caggaccaga gaatccggtg gtatctgctg tccatgggca gcaacgagaa tatccacagc     3240

atccacttca gcggccacgt gttcaccgtg cggaagaaag aagagtacaa gatggccctg     3300

tacaacctgt accccggcgt gttcgagaca gtggagatgc tgcccagcaa ggccggcatc     3360

tggcgggtgg agtgtctgat cggcgagcac ctgcacgctg gcatgagcac cctgtttctg     3420

gtgtacagca acaagtgcca gaccccactg ggcatggcct ctggccacat ccgggacttc     3480

cagatcaccg cctccggcca gtacggccag tgggccccca agctggccag actgcactac     3540

agcggcagca tcaacgcctg gtccaccaaa gagcccttca gctggatcaa ggtggacctg     3600

ctggccccta tgatcatcca cggcattaag acccagggcg ccaggcagaa gttcagcagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

cggggcaaca gcaccggcac cctgatggtg ttcttcggca atgtggacag cagcggcatc     3780

aagcacaaca tcttcaaccc ccccatcatt gcccggtaca tccggctgca ccccacccac     3840

tacagcatta gatccacact gagaatggaa ctgatgggct gcgacctgaa ctcctgcagc     3900

atgcctctgg gcatggaaag caaggccatc agcgacgccc agatcacagc cagcagctac     3960

ttcaccaaca tgttcgccac ctggtccccc tccaaggcca ggctgcacct gcagggccgg     4020

tccaacgcct ggcggcctca ggtcaacaac cccaaagaat ggctgcaggt ggactttcag     4080

aaaaccatga aggtgaccgg cgtgaccacc cagggcgtga aaagcctgct gaccagcatg     4140

tacgtgaaag agtttctgat cagcagctct caggatggcc accagtggac cctgttcttt     4200

cagaacggca aggtgaaagt gttccagggc aaccaggact ccttcacccc cgtggtgaac     4260

tccctggacc cccccctgct gacccgctac ctgagaatcc acccccagtc ttgggtgcac     4320

cagatcgccc tcaggatgga agtcctggga tgtgaggccc aggatctgta ctgatga        4377


<210>  16
<211>  4377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CO FVIII-RH

<400>  16
atgcagatcg agctgtccac ctgctttttt ctgtgcctgc tgcggttctg cttcagcgcc       60

acccggcggt actacctggg cgccgtggag ctgtcctggg actacatgca gagcgacctg      120

ggcgagctgc ccgtggacgc ccggttcccc cccagagtgc ccaagagctt ccccttcaac      180

accagcgtgg tgtacaagaa aaccctgttc gtggagttca ccgaccacct gttcaatatc      240

gccaagccca ggcccccctg gatgggcctg ctgggcccca ccatccaggc cgaggtgtac      300

gacaccgtgg tgatcaccct gaagaacatg gccagccacc ccgtgagcct gcacgccgtg      360

ggcgtgagct actggaaggc cagcgagggc gccgagtacg acgaccagac cagccagcgg      420

gagaaagaag atgacaaggt gttccctggc ggcagccaca cctacgtgtg gcaggtgctg      480

aaagaaaacg gccccatggc ctccgacccc ctgtgcctga cctacagcta cctgagccac      540

gtggacctgg tgaaggacct gaacagcggc ctgatcggcg ctctgctcgt ctgccgggag      600

ggcagcctgg ccaaagagaa aacccagacc ctgcacaagt tcatcctgct gttcgccgtg      660

ttcgacgagg gcaagagctg gcacagcgag acaaagaaca gcctgatgca ggaccgggac      720

gccgcctctg ccagagcctg gcccaagatg cacaccgtga acggctacgt gaacagaagc      780

ctgcccggcc tgattggctg ccaccggaag agcgtgtact ggcacgtgat cggcatgggc      840

accacacccg aggtgcacag catctttctg gaagggcaca cctttctggt ccggaaccac      900

cggcaggcca gcctggaaat cagccctatc accttcctga ccgcccagac actgctgatg      960

gacctgggcc agttcctgct gttttgccac atcagctctc accagcacga cggcatggaa     1020

gcctacgtga aggtggactc ttgccccgag gaaccccagc tgcggatgaa gaacaacgag     1080

gaagccgagg actacgacga cgacctgacc gacagcgaga tggacgtggt gcggttcgac     1140

gacgacaaca gccccagctt catccagatc agaagcgtgg ccaagaagca ccccaagacc     1200

tgggtgcact atatcgccgc cgaggaagag gactgggact acgcccccct ggtgctggcc     1260

cccgacgaca gaagctacaa gagccagtac ctgaacaatg gcccccagcg gatcggccgg     1320

aagtacaaga aagtgcggtt catggcctac accgacgaga cattcaagac ccgggaggcc     1380

atccagcacg agagcggcat cctgggcccc ctgctgtacg gcgaagtggg cgacacactg     1440

ctgatcatct tcaagaacca ggctagccgg ccctacaaca tctaccccca cggcatcacc     1500

gacgtgcggc ccctgtacag caggcggctg cccaagggcg tgaagcacct gaaggacttc     1560

cccatcctgc ccggcgagat cttcaagtac aagtggaccg tgaccgtgga ggacggcccc     1620

accaagagcg accccagatg cctgacccgg tactacagca gcttcgtgaa catggaacgg     1680

gacctggcct ccgggctgat cggacctctg ctgatctgct acaaagaaag cgtggaccag     1740

cggggcaacc agatcatgag cgacaagcgg aacgtgatcc tgttcagcgt gttcgatgag     1800

aaccggtcct ggtatctgac cgagaacatc cagcggtttc tgcccaaccc tgccggcgtg     1860

cagctggaag atcccgagtt ccaggccagc aacatcatgc actccatcaa tggctacgtg     1920

ttcgactctc tgcagctctc cgtgtgtctg cacgaggtgg cctactggta catcctgagc     1980

atcggcgccc agaccgactt cctgagcgtg ttcttcagcg gctacacctt caagcacaag     2040

atggtgtacg aggacaccct gaccctgttc cctttcagcg gcgagacagt gttcatgagc     2100

atggaaaacc ccggcctgtg gattctgggc tgccacaaca gcgacttccg gaaccggggc     2160

atgaccgccc tgctgaaggt gtccagctgc gacaagaaca ccggcgacta ctacgaggac     2220

agctacgagg atatcagcgc ctacctgctg tccaagaaca acgccatcga accccggagc     2280

ttcagccaga acccccccgt gctgacgcat caccagcggg agatcacccg gacaaccctg     2340

cagtccgacc aggaagagat cgattacgac gacaccatca gcgtggagat gaagaaagag     2400

gatttcgata tctacgacga ggacgagaac cagagcccca gaagcttcca gaagaaaacc     2460

cggcactact tcattgccgc cgtggagagg ctgtgggact acggcatgag ttctagcccc     2520

cacgtgctgc ggaaccgggc ccagagcggc agcgtgcccc agttcaagaa agtggtgttc     2580

caggaattca cagacggcag cttcacccag cctctgtata gaggcgagct gaacgagcac     2640

ctggggctgc tggggcccta catcagggcc gaagtggagg acaacatcat ggtgaccttc     2700

cggaatcagg ccagcagacc ctactccttc tacagcagcc tgatcagcta cgaagaggac     2760

cagcggcagg gcgccgaacc ccggaagaac ttcgtgaagc ccaacgaaac caagacctac     2820

ttctggaaag tgcagcacca catggccccc accaaggacg agttcgactg caaggcctgg     2880

gcctacttca gcgacgtgga tctggaaaag gacgtgcact ctggactgat tggcccactc     2940

ctggtctgcc acactaacac cctcaacccc gcccacggcc gccaggtgac cgtgcaggaa     3000

ttcgccctgt tcttcaccat cttcgacgag acaaagtcct ggtacttcac cgagaatatg     3060

gaacggaact gcagagcccc ctgcaacatc cagatggaag atcctacctt caaagagaac     3120

taccggttcc acgccatcaa cggctacatc atggacaccc tgcctggcct ggtgatggcc     3180

caggaccaga gaatccggtg gtatctgctg tccatgggca gcaacgagaa tatccacagc     3240

atccacttca gcggccacgt gttcaccgtg cggaagaaag aagagtacaa gatggccctg     3300

tacaacctgt accccggcgt gttcgagaca gtggagatgc tgcccagcaa ggccggcatc     3360

tggcgggtgg agtgtctgat cggcgagcac ctgcacgctg gcatgagcac cctgtttctg     3420

gtgtacagca acaagtgcca gaccccactg ggcatggcct ctggccacat ccgggacttc     3480

cagatcaccg cctccggcca gtacggccag tgggccccca agctggccag actgcactac     3540

agcggcagca tcaacgcctg gtccaccaaa gagcccttca gctggatcaa ggtggacctg     3600

ctggccccta tgatcatcca cggcattaag acccagggcg ccaggcagaa gttcagcagc     3660

ctgtacatca gccagttcat catcatgtac agcctggacg gcaagaagtg gcagacctac     3720

cggggcaaca gcaccggcac cctgatggtg ttcttcggca atgtggacag cagcggcatc     3780

aagcacaaca tcttcaaccc ccccatcatt gcccggtaca tccggctgca ccccacccac     3840

tacagcatta gatccacact gagaatggaa ctgatgggct gcgacctgaa ctcctgcagc     3900

atgcctctgg gcatggaaag caaggccatc agcgacgccc agatcacagc cagcagctac     3960

ttcaccaaca tgttcgccac ctggtccccc tccaaggcca ggctgcacct gcagggccgg     4020

tccaacgcct ggcggcctca ggtcaacaac cccaaagaat ggctgcaggt ggactttcag     4080

aaaaccatga aggtgaccgg cgtgaccacc cagggcgtga aaagcctgct gaccagcatg     4140

tacgtgaaag agtttctgat cagcagctct caggatggcc accagtggac cctgttcttt     4200

cagaacggca aggtgaaagt gttccagggc aaccaggact ccttcacccc cgtggtgaac     4260

tccctggacc cccccctgct gacccgctac ctgagaatcc acccccagtc ttgggtgcac     4320

cagatcgccc tcaggatgga agtcctggga tgtgaggccc aggatctgta ctgatga        4377


<210>  17
<211>  1272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FIX

<400>  17
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta       60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt      120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt      180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac      240

actgaaagaa caactgaatt ttggaagcag tatgttgatg taacatgtaa cattaagaat      300

ggcagatgcg agcagttttg taaaaatagt gctgataaca aggtggtttg ctcctgtact      360

gagggatatc gacttgcaga aaaccagaag tcctgtgaac cagcagtgcc atttccatgt      420

ggaagagttt ctgtttcaca aacttctaag ctcacccgtg ctgagactgt ttttcctgat      480

gtggactatg taaattctac tgaagctgaa accattttgg ataacatcac tcaaagcacc      540

caatcattta atgacttcac tcgggttgtt ggtggagaag atgccaaacc aggtcaattc      600

ccttggcagg ttgttttgaa tggtaaagtt gatgcattct gtggaggctc tatcgttaat      660

gaaaaatgga ttgtaactgc tgcccactgt gttgaaactg gtgttaaaat tacagttgtc      720

gcaggtgaac ataatattga ggagacagaa catacagagc aaaagcgaaa tgtgattcga      780

attattcctc accacaacta caatgcagct attaataagt acaaccatga cattgccctt      840

ctggaactgg acgaaccctt agtgctaaac agctacgtta cacctatttg cattgctgac      900

aaggaataca cgaacatctt cctcaaattt ggatctggct atgtaagtgg ctggggaaga      960

gtcttccaca aagggagatc agctttagtt cttcagtacc ttagagttcc acttgttgac     1020

cgagccacat gtcttcgatc tacaaagttc accatctata acaacatgtt ctgtgctggc     1080

ttccatgaag gaggtagaga ttcatgtcaa ggagatagtg ggggacccca tgttactgaa     1140

gtggaaggga ccagtttctt aactggaatt attagctggg gtgaagagtg tgcaatgaaa     1200

ggcaaatatg gaatatatac caaggtatcc cggtatgtca actggattaa ggaaaaaaca     1260

aagctcactt aa                                                         1272


<210>  18
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FVII

<400>  18
atggtctccc aggccctcag gctcctctgc cttctgcttg ggcttcaggg ctgcctggct       60

gcaggcgggg tcgctaaggc ctcaggagga gaaacacggg acatgccgtg gaagccgggg      120

cctcacagag tcttcgtaac ccaggaggaa gcccacggcg tcctgcaccg gcgccggcgc      180

gccaacgcgt tcctggagga gctgcggccg ggctccctgg agagggagtg caaggaggag      240

cagtgctcct tcgaggaggc ccgggagatc ttcaaggacg cggagaggac gaagctgttc      300

tggatttctt acagtgatgg ggaccagtgt gcctcaagtc catgccagaa tgggggctcc      360

tgcaaggacc agctccagtc ctatatctgc ttctgcctcc ctgccttcga gggccggaac      420

tgtgagacgc acaaggatga ccagctgatc tgtgtgaacg agaacggcgg ctgtgagcag      480

tactgcagtg accacacggg caccaagcgc tcctgtcggt gccacgaggg gtactctctg      540

ctggcagacg gggtgtcctg cacacccaca gttgaatatc catgtggaaa aatacctatt      600

ctagaaaaaa gaaatgccag caaaccccaa ggccgaattg tggggggcaa ggtgtgcccc      660

aaaggggagt gtccatggca ggtcctgttg ttggtgaatg gagctcagtt gtgtgggggg      720

accctgatca acaccatctg ggtggtctcc gcggcccact gtttcgacaa aatcaagaac      780

tggaggaacc tgatcgcggt gctgggcgag cacgacctca gcgagcacga cggggatgag      840

cagagccggc gggtggcgca ggtcatcatc cccagcacgt acgtcccggg caccaccaac      900

cacgacatcg cgctgctccg cctgcaccag cccgtggtcc tcactgacca tgtggtgccc      960

ctctgcctgc ccgaacggac gttctctgag aggacgctgg ccttcgtgcg cttctcattg     1020

gtcagcggct ggggccagct gctggaccgt ggcgccacgg ccctggagct catggtcctc     1080

aacgtgcccc ggctgatgac ccaggactgc ctgcagcagt cacggaaggt gggagactcc     1140

ccaaatatca cggagtacat gttctgtgcc ggctactcgg atggcagcaa ggactcctgc     1200

aagggggaca gtggaggccc acatgccacc cactaccggg gcacgtggta cctgacgggc     1260

atcgtcagct ggggccaggg ctgcgcaacc gtgggccact ttggggtgta caccagggtc     1320

tcccagtaca tcgagtggct gcaaaagctc atgcgctcag agccacgccc aggagtcctc     1380

ctgcgagccc catttcccta g                                               1401


<210>  19
<211>  6675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FV

<400>  19
atgttcccag gctgcccacg cctctgggtc ctggtggtct tgggcaccag ctgggtaggc       60

tgggggagcc aagggacaga agcggcacag ctaaggcagt tctacgtggc tgctcagggc      120

atcagttgga gctaccgacc tgagcccaca aactcaagtt tgaatctttc tgtaacttcc      180

tttaagaaaa ttgtctacag agagtatgaa ccatatttta agaaagaaaa accacaatct      240

accatttcag gacttcttgg gcctacttta tatgctgaag tcggagacat cataaaagtt      300

cactttaaaa ataaggcaga taagcccttg agcatccatc ctcaaggaat taggtacagt      360

aaattatcag aaggtgcttc ttaccttgac cacacattcc ctgcggagaa gatggacgac      420

gctgtggctc caggccgaga atacacctat gaatggagta tcagtgagga cagtggaccc      480

acccatgatg accctccatg cctcacacac atctattact cccatgaaaa tctgatcgag      540

gatttcaact cggggctgat tgggcccctg cttatctgta aaaaagggac cctaactgag      600

ggtgggacac agaagacgtt tgacaagcaa atcgtgctac tatttgctgt gtttgatgaa      660

agcaagagct ggagccagtc atcatcccta atgtacacag tcaatggata tgtgaatggg      720

acaatgccag atataacagt ttgtgcccat gaccacatca gctggcatct gctgggaatg      780

agctcggggc cagaattatt ctccattcat ttcaacggcc aggtcctgga gcagaaccat      840

cataaggtct cagccatcac ccttgtcagt gctacatcca ctaccgcaaa tatgactgtg      900

ggcccagagg gaaagtggat catatcttct ctcaccccaa aacatttgca agctgggatg      960

caggcttaca ttgacattaa aaactgccca aagaaaacca ggaatcttaa gaaaataact     1020

cgtgagcaga ggcggcacat gaagaggtgg gaatacttca ttgctgcaga ggaagtcatt     1080

tgggactatg cacctgtaat accagcgaat atggacaaaa aatacaggtc tcagcatttg     1140

gataatttct caaaccaaat tggaaaacat tataagaaag ttatgtacac acagtacgaa     1200

gatgagtcct tcaccaaaca tacagtgaat cccaatatga aagaagatgg gattttgggt     1260

cctattatca gagcccaggt cagagacaca ctcaaaatcg tgttcaaaaa tatggccagc     1320

cgcccctata gcatttaccc tcatggagtg accttctcgc cttatgaaga tgaagtcaac     1380

tcttctttca cctcaggcag gaacaacacc atgatcagag cagttcaacc aggggaaacc     1440

tatacttata agtggaacat cttagagttt gatgaaccca cagaaaatga tgcccagtgc     1500

ttaacaagac catactacag tgacgtggac atcatgagag acatcgcctc tgggctaata     1560

ggactacttc taatctgtaa gagcagatcc ctggacaggc gaggaataca gagggcagca     1620

gacatcgaac agcaggctgt gtttgctgtg tttgatgaga acaaaagctg gtaccttgag     1680

gacaacatca acaagttttg tgaaaatcct gatgaggtga aacgtgatga ccccaagttt     1740

tatgaatcaa acatcatgag cactatcaat ggctatgtgc ctgagagcat aactactctt     1800

ggattctgct ttgatgacac tgtccagtgg cacttctgta gtgtggggac ccagaatgaa     1860

attttgacca tccacttcac tgggcactca ttcatctatg gaaagaggca tgaggacacc     1920

ttgaccctct tccccatgcg tggagaatct gtgacggtca caatggataa tgttggaact     1980

tggatgttaa cttccatgaa ttctagtcca agaagcaaaa agctgaggct gaaattcagg     2040

gatgttaaat gtatcccaga tgatgatgaa gactcatatg agatttttga acctccagaa     2100

tctacagtca tggctacacg gaaaatgcat gatcgtttag aacctgaaga tgaagagagt     2160

gatgctgact atgattacca gaacagactg gctgcagcat taggaatcag gtcattccga     2220

aactcatcat tgaatcagga agaagaagag ttcaatctta ctgccctagc tctggagaat     2280

ggcactgaat tcgtttcttc aaacacagat ataattgttg gttcaaatta ttcttcccca     2340

agtaatatta gtaagttcac tgtcaataac cttgcagaac ctcagaaagc cccttctcac     2400

caacaagcca ccacagctgg ttccccactg agacacctca ttggcaagaa ctcagttctc     2460

aattcttcca cagcagagca ttccagccca tattctgaag accctataga ggatcctcta     2520

cagccagatg tcacagggat acgtctactt tcacttggtg ctggagaatt caaaagtcaa     2580

gaacatgcta agcataaggg acccaaggta gaaagagatc aagcagcaaa gcacaggttc     2640

tcctggatga aattactagc acataaagtt gggagacacc taagccaaga cactggttct     2700

ccttccggaa tgaggccctg ggaggacctt cctagccaag acactggttc tccttccaga     2760

atgaggccct ggaaggaccc tcctagtgat ctgttactct taaaacaaag taactcatct     2820

aagattttgg ttgggagatg gcatttggct tctgagaaag gtagctatga aataatccaa     2880

gatactgatg aagacacagc tgttaacaat tggctgatca gcccccagaa tgcctcacgt     2940

gcttggggag aaagcacccc tcttgccaac aagcctggaa agcagagtgg ccacccaaag     3000

tttcctagag ttagacataa atctctacaa gtaagacagg atggaggaaa gagtagactg     3060

aagaaaagcc agtttctcat taagacacga aaaaagaaaa aagagaagca cacacaccat     3120

gctcctttat ctccgaggac ctttcaccct ctaagaagtg aagcctacaa cacattttca     3180

gaaagaagac ttaagcattc gttggtgctt cataaatcca atgaaacatc tcttcccaca     3240

gacctcaatc agacattgcc ctctatggat tttggctgga tagcctcact tcctgaccat     3300

aatcagaatt cctcaaatga cactggtcag gcaagctgtc ctccaggtct ttatcagaca     3360

gtgcccccag aggaacacta tcaaacattc cccattcaag accctgatca aatgcactct     3420

acttcagacc ccagtcacag atcctcttct ccagagctca gtgaaatgct tgagtatgac     3480

cgaagtcaca agtccttccc cacagatata agtcaaatgt ccccttcctc agaacatgaa     3540

gtctggcaga cagtcatctc tccagacctc agccaggtga ccctctctcc agaactcagc     3600

cagacaaacc tctctccaga cctcagccac acgactctct ctccagaact cattcagaga     3660

aacctttccc cagccctcgg tcagatgccc atttctccag acctcagcca tacaaccctt     3720

tctccagacc tcagccatac aaccctttct ttagacctca gccagacaaa cctctctcca     3780

gaactcagtc agacaaacct ttctccagcc ctcggtcaga tgcccctttc tccagacctc     3840

agccatacaa ccctttctct agacttcagc cagacaaacc tctctccaga actcagccat     3900

atgactctct ctccagaact cagtcagaca aacctttccc cagccctcgg tcagatgccc     3960

atttctccag acctcagcca tacaaccctt tctctagact tcagccagac aaacctctct     4020

ccagaactca gtcaaacaaa cctttcccca gccctcggtc agatgcccct ttctccagac     4080

cccagccata caaccctttc tctagacctc agccagacaa acctctctcc agaactcagt     4140

cagacaaacc tttccccaga cctcagtgag atgcccctct ttgcagatct cagtcaaatt     4200

ccccttaccc cagacctcga ccagatgaca ctttctccag accttggtga gacagatctt     4260

tccccaaact ttggtcagat gtccctttcc ccagacctca gccaggtgac tctctctcca     4320

gacatcagtg acaccaccct tctcccggat ctcagccaga tatcacctcc tccagacctt     4380

gatcagatat tctacccttc tgaatctagt cagtcattgc ttcttcaaga atttaatgag     4440

tcttttcctt atccagacct tggtcagatg ccatctcctt catctcctac tctcaatgat     4500

acttttctat caaaggaatt taatccactg gttatagtgg gcctcagtaa agatggtaca     4560

gattacattg agatcattcc aaaggaagag gtccagagca gtgaagatga ctatgctgaa     4620

attgattatg tgccctatga tgacccctac aaaactgatg ttaggacaaa catcaactcc     4680

tccagagatc ctgacaacat tgcagcatgg tacctccgca gcaacaatgg aaacagaaga     4740

aattattaca ttgctgctga agaaatatcc tgggattatt cagaatttgt acaaagggaa     4800

acagatattg aagactctga tgatattcca gaagatacca catataagaa agtagttttt     4860

cgaaagtacc tcgacagcac ttttaccaaa cgtgatcctc gaggggagta tgaagagcat     4920

ctcggaattc ttggtcctat tatcagagct gaagtggatg atgttatcca agttcgtttt     4980

aaaaatttag catccagacc gtattctcta catgcccatg gactttccta tgaaaaatca     5040

tcagagggaa agacttatga agatgactct cctgaatggt ttaaggaaga taatgctgtt     5100

cagccaaata gcagttatac ctacgtatgg catgccactg agcgatcagg gccagaaagt     5160

cctggctctg cctgtcgggc ttgggcctac tactcagctg tgaacccaga aaaagatatt     5220

cactcaggct tgataggtcc cctcctaatc tgccaaaaag gaatactaca taaggacagc     5280

aacatgccta tggacatgag agaatttgtc ttactattta tgacctttga tgaaaagaag     5340

agctggtact atgaaaagaa gtcccgaagt tcttggagac tcacatcctc agaaatgaaa     5400

aaatcccatg agtttcacgc cattaatggg atgatctaca gcttgcctgg cctgaaaatg     5460

tatgagcaag agtgggtgag gttacacctg ctgaacatag gcggctccca agacattcac     5520

gtggttcact ttcacggcca gaccttgctg gaaaatggca ataaacagca ccagttaggg     5580

gtctggcccc ttctgcctgg ttcatttaaa actcttgaaa tgaaggcatc aaaacctggc     5640

tggtggctcc taaacacaga ggttggagaa aaccagagag cagggatgca aacgccattt     5700

cttatcatgg acagagactg taggatgcca atgggactaa gcactggtat catatctgat     5760

tcacagatca aggcttcaga gtttctgggt tactgggagc ccagattagc aagattaaac     5820

aatggtggat cttataatgc ttggagtgta gaaaaacttg cagcagaatt tgcctctaaa     5880

ccttggatcc aggtggacat gcaaaaggaa gtcataatca cagggatcca gacccaaggt     5940

gccaaacact acctgaagtc ctgctatacc acagagttct atgtagctta cagttccaac     6000

cagatcaact ggcagatctt caaagggaac agcacaagga atgtgatgta ttttaatggc     6060

aattcagatg cctctacaat aaaagagaat cagtttgacc cacctattgt ggctagatat     6120

attaggatct ctccaactcg agcctataac agacctaccc ttcgattgga actgcaaggt     6180

tgtgaggtaa atggatgttc cacacccctg ggtatggaaa atggaaagat agaaaacaag     6240

caaatcacag cttcttcgtt taagaaatct tggtggggag attactggga acccttccgt     6300

gcccgtctga atgcccaggg acgtgtgaat gcctggcaag ccaaggcaaa caacaataag     6360

cagtggctag aaattgatct actcaagatc aagaagataa cggcaattat aacacagggc     6420

tgcaagtctc tgtcctctga aatgtatgta aagagctata ccatccacta cagtgagcag     6480

ggagtggaat ggaaaccata caggctgaaa tcctccatgg tggacaagat ttttgaagga     6540

aatactaata ccaaaggaca tgtgaagaac tttttcaacc ccccaatcat ttccaggttt     6600

atccgtgtca ttcctaaaac atggaatcaa agtattgcac ttcgcctgga actctttggc     6660

tgtgatattt actag                                                      6675


<210>  20
<211>  1272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FIX-Padua

<400>  20
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta       60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt      120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt      180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac      240

actgaaagaa caactgaatt ttggaagcag tatgttgatg taacatgtaa cattaagaat      300

ggcagatgcg agcagttttg taaaaatagt gctgataaca aggtggtttg ctcctgtact      360

gagggatatc gacttgcaga aaaccagaag tcctgtgaac cagcagtgcc atttccatgt      420

ggaagagttt ctgtttcaca aacttctaag ctcacccgtg ctgagactgt ttttcctgat      480

gtggactatg taaattctac tgaagctgaa accattttgg ataacatcac tcaaagcacc      540

caatcattta atgacttcac tcgggttgtt ggtggagaag atgccaaacc aggtcaattc      600

ccttggcagg ttgttttgaa tggtaaagtt gatgcattct gtggaggctc tatcgttaat      660

gaaaaatgga ttgtaactgc tgcccactgt gttgaaactg gtgttaaaat tacagttgtc      720

gcaggtgaac ataatattga ggagacagaa catacagagc aaaagcgaaa tgtgattcga      780

attattcctc accacaacta caatgcagct attaataagt acaaccatga cattgccctt      840

ctggaactgg acgaaccctt agtgctaaac agctacgtta cacctatttg cattgctgac      900

aaggaataca cgaacatctt cctcaaattt ggatctggct atgtaagtgg ctggggaaga      960

gtcttccaca aagggagatc agctttagtt cttcagtacc ttagagttcc acgagttgac     1020

cgagccacat gtcttcgatc tacaaagttc accatctata acaacatgtt ctgtgctggc     1080

ttccatgaag gaggtagaga ttcatgtcaa ggagatagtg ggggacccca tgttactgaa     1140

gtggaaggga ccagtttctt aactggaatt attagctggg gtgaagagtg tgcaatgaaa     1200

ggcaaatatg gaatatatac caaggtatcc cggtatgtca actggattaa ggaaaaaaca     1260

aagctcactt aa                                                         1272


<210>  21
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pF8_short_XhoI_FOR

<400>  21
cagcctcgag gagctcacca tggctacatt ctga                                   34


<210>  22
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pF8_AgeI_REV

<400>  22
cgaaccggtg acttattgct acaaatgttc aac                                    33


<210>  23
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pF8_ECL_XhoI_FOR

<400>  23
cagcctcgag gtttttaaaa caatagttgc ctaacc                                 36


<210>  24
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pF8_AgeI_REV

<400>  24
cgaaccggtg acttattgct acaaatgttc aac                                    33


<210>  25
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pF8_enhancer_Short_MfeI_FOR

<400>  25
cttcaattgg gggctcgctc gctcagtac                                         29


<210>  26
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pF8_enhancer_MfeI_REV

<400>  26
cttcaattgc tcaactccta tggtgccac                                         29


<210>  27
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pF8_enhancer_Long_MfeI_FOR

<400>  27
cttcaattgt cgccaccact tggcttccg                                         29


<210>  28
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pF8_Long_XhoI_FOR

<400>  28
cagcctcgac gacgagttcc cacaaacgtt acc                                    33


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DENV RF2_FOR

<400>  29
gacccacctc ccaaccccg                                                    19


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFP_REV

<400>  30
cgtcgccgtc cagctcgacc ag                                                22

