                         SEQUENCE LISTING

<110>  PFIZER INC.
       Tatlock, John H.
       McAlpine, Indrawan J
       Tran-Dube, Michelle B
       Rui, Eugene Y
       Wythes, Martin J
       Kumpf, Robert A
       McTigue, Michele A
       Patman, Ryan
 
<120>  SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER 
       AGENTS

<130>  PC72307A

<140>  62/506,076
<141>  2017-05-15

<150>  62/346,226
<151>  2016-06-06

<150>  62/376,856
<151>  2016-08-18

<150>  62/431,714
<151>  2016-12-08

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Arg Ala Thr Ala Ala Met 
1               5                   10                  15      


Ala Val Gly Gly Ala Gly Gly Ser Arg Val Ser Ser Gly Arg Asp Leu 
            20                  25                  30          


Asn Cys Val Pro Glu Ile Ala Asp Thr Leu Gly Ala Val Ala Lys Gln 
        35                  40                  45              


Gly Phe Asp Phe Leu Cys Met Pro Val Phe His Pro Arg Phe Lys Arg 
    50                  55                  60                  


Glu Phe Ile Gln Glu Pro Ala Lys Asn Arg Pro Gly Pro Gln Thr Arg 
65                  70                  75                  80  


Ser Asp Leu Leu Leu Ser Gly Arg Asp Trp Asn Thr Leu Ile Val Gly 
                85                  90                  95      


Lys Leu Ser Pro Trp Ile Arg Pro Asp Ser Lys Val Glu Lys Ile Arg 
            100                 105                 110         


Arg Asn Ser Glu Ala Ala Met Leu Gln Glu Leu Asn Phe Gly Ala Tyr 
        115                 120                 125             


Leu Gly Leu Pro Ala Phe Leu Leu Pro Leu Asn Gln Glu Asp Asn Thr 
    130                 135                 140                 


Asn Leu Ala Arg Val Leu Thr Asn His Ile His Thr Gly His His Ser 
145                 150                 155                 160 


Ser Met Phe Trp Met Arg Val Pro Leu Val Ala Pro Glu Asp Leu Arg 
                165                 170                 175     


Asp Asp Ile Ile Glu Asn Ala Pro Thr Thr His Thr Glu Glu Tyr Ser 
            180                 185                 190         


Gly Glu Glu Lys Thr Trp Met Trp Trp His Asn Phe Arg Thr Leu Cys 
        195                 200                 205             


Asp Tyr Ser Lys Arg Ile Ala Val Ala Leu Glu Ile Gly Ala Asp Leu 
    210                 215                 220                 


Pro Ser Asn His Val Ile Asp Arg Trp Leu Gly Glu Pro Ile Lys Ala 
225                 230                 235                 240 


Ala Ile Leu Pro Thr Ser Ile Phe Leu Thr Asn Lys Lys Gly Phe Pro 
                245                 250                 255     


Val Leu Ser Lys Met His Gln Arg Leu Ile Phe Arg Leu Leu Lys Leu 
            260                 265                 270         


Glu Val Gln Phe Ile Ile Thr Gly Thr Asn His His Ser Glu Lys Glu 
        275                 280                 285             


Phe Cys Ser Tyr Leu Gln Tyr Leu Glu Tyr Leu Ser Gln Asn Arg Pro 
    290                 295                 300                 


Pro Pro Asn Ala Tyr Glu Leu Phe Ala Lys Gly Tyr Glu Asp Tyr Leu 
305                 310                 315                 320 


Gln Ser Pro Leu Gln Pro Leu Met Asp Asn Leu Glu Ser Gln Thr Tyr 
                325                 330                 335     


Glu Val Phe Glu Lys Asp Pro Ile Lys Tyr Ser Gln Tyr Gln Gln Ala 
            340                 345                 350         


Ile Tyr Lys Cys Leu Leu Asp Arg Val Pro Glu Glu Glu Lys Asp Thr 
        355                 360                 365             


Asn Val Gln Val Leu Met Val Leu Gly Ala Gly Arg Gly Pro Leu Val 
    370                 375                 380                 


Asn Ala Ser Leu Arg Ala Ala Lys Gln Ala Asp Arg Arg Ile Lys Leu 
385                 390                 395                 400 


Tyr Ala Val Glu Lys Asn Pro Asn Ala Val Val Thr Leu Glu Asn Trp 
                405                 410                 415     


Gln Phe Glu Glu Trp Gly Ser Gln Val Thr Val Val Ser Ser Asp Met 
            420                 425                 430         


Arg Glu Trp Val Ala Pro Glu Lys Ala Asp Ile Ile Val Ser Glu Leu 
        435                 440                 445             


Leu Gly Ser Phe Ala Asp Asn Glu Leu Ser Pro Glu Cys Leu Asp Gly 
    450                 455                 460                 


Ala Gln His Phe Leu Lys Asp Asp Gly Val Ser Ile Pro Gly Glu Tyr 
465                 470                 475                 480 


Thr Ser Phe Leu Ala Pro Ile Ser Ser Ser Lys Leu Tyr Asn Glu Val 
                485                 490                 495     


Arg Ala Cys Arg Glu Lys Asp Arg Asp Pro Glu Ala Gln Phe Glu Met 
            500                 505                 510         


Pro Tyr Val Val Arg Leu His Asn Phe His Gln Leu Ser Ala Pro Gln 
        515                 520                 525             


Pro Cys Phe Thr Phe Ser His Pro Asn Arg Asp Pro Met Ile Asp Asn 
    530                 535                 540                 


Asn Arg Tyr Cys Thr Leu Glu Phe Pro Val Glu Val Asn Thr Val Leu 
545                 550                 555                 560 


His Gly Phe Ala Gly Tyr Phe Glu Thr Val Leu Tyr Gln Asp Ile Thr 
                565                 570                 575     


Leu Ser Ile Arg Pro Glu Thr His Ser Pro Gly Met Phe Ser Trp Phe 
            580                 585                 590         


Pro Ile Leu Phe Pro Ile Lys Gln Pro Ile Thr Val Arg Glu Gly Gln 
        595                 600                 605             


Thr Ile Cys Val Arg Phe Trp Arg Cys Ser Asn Ser Lys Lys Val Trp 
    610                 615                 620                 


Tyr Glu Trp Ala Val Thr Ala Pro Val Cys Ser Ala Ile His Asn Pro 
625                 630                 635                 640 


Thr Gly Arg Ser Tyr Thr Ile Gly Leu 
                645                 


<210>  2
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Lys Glu Thr Pro Pro Pro Leu Val Pro Pro Ala Ala Arg Glu 
1               5                   10                  15      


Trp Asn Leu Pro Pro Asn Ala Pro Ala Cys Met Glu Arg Gln Leu Glu 
            20                  25                  30          


Ala Ala Arg Tyr Arg Ser Asp Gly Ala Leu Leu Leu Gly Ala Ser Ser 
        35                  40                  45              


Leu Ser Gly Arg Cys Trp Ala Gly Ser Leu Trp Leu Phe Lys Asp Pro 
    50                  55                  60                  


Cys Ala Ala Pro Asn Glu Gly Phe Cys Ser Ala Gly Val Gln Thr Glu 
65                  70                  75                  80  


Ala Gly Val Ala Asp Leu Thr Trp Val Gly Glu Arg Gly Ile Leu Val 
                85                  90                  95      


Ala Ser Asp Ser Gly Ala Val Glu Leu Trp Glu Leu Asp Glu Asn Glu 
            100                 105                 110         


Thr Leu Ile Val Ser Lys Phe Cys Lys Tyr Glu His Asp Asp Ile Val 
        115                 120                 125             


Ser Thr Val Ser Val Leu Ser Ser Gly Thr Gln Ala Val Ser Gly Ser 
    130                 135                 140                 


Lys Asp Ile Cys Ile Lys Val Trp Asp Leu Ala Gln Gln Val Val Leu 
145                 150                 155                 160 


Ser Ser Tyr Arg Ala His Ala Ala Gln Val Thr Cys Val Ala Ala Ser 
                165                 170                 175     


Pro His Lys Asp Ser Val Phe Leu Ser Cys Ser Glu Asp Asn Arg Ile 
            180                 185                 190         


Leu Leu Trp Asp Thr Arg Cys Pro Lys Pro Ala Ser Gln Ile Gly Cys 
        195                 200                 205             


Ser Ala Pro Gly Tyr Leu Pro Thr Ser Leu Ala Trp His Pro Gln Gln 
    210                 215                 220                 


Ser Glu Val Phe Val Phe Gly Asp Glu Asn Gly Thr Val Ser Leu Val 
225                 230                 235                 240 


Asp Thr Lys Ser Thr Ser Cys Val Leu Ser Ser Ala Val His Ser Gln 
                245                 250                 255     


Cys Val Thr Gly Leu Val Phe Ser Pro His Ser Val Pro Phe Leu Ala 
            260                 265                 270         


Ser Leu Ser Glu Asp Cys Ser Leu Ala Val Leu Asp Ser Ser Leu Ser 
        275                 280                 285             


Glu Leu Phe Arg Ser Gln Ala His Arg Asp Phe Val Arg Asp Ala Thr 
    290                 295                 300                 


Trp Ser Pro Leu Asn His Ser Leu Leu Thr Thr Val Gly Trp Asp His 
305                 310                 315                 320 


Gln Val Val His His Val Val Pro Thr Glu Pro Leu Pro Ala Pro Gly 
                325                 330                 335     


Pro Ala Ser Val Thr Glu 
            340         


