               SEQUENCE LISTING

<110> Imperial Innovations Limited
      INSTITUT PASTEUR

<120> METHODS

<130> ICOBY/P63641PC

<140> GBPCT/GB2017/051692
<141> 2017-06-09

<150> GB1610162.8
<151> 2016-06-10

<160> 151

<170> BiSSAP 1.3.6

<210> 1
<211> 404
<212> PRT
<213> Zika virus


<220> 
<223> Zika virus (ZIKV, KJ776791, strain H-PF-2013_French_Polynesia)
      Envelope portion of polyprotein sequence

<400> 1
Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      
Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          
Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              
Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  
Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  
Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      
Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         
Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             
Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 
Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 
Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     
Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         
Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             
Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 
Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 
Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     
Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         
Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             
Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 
Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 
Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     
Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         
Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             
Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 
Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 
His Arg Ser Gly 
                

<210> 2
<211> 395
<212> PRT
<213> Dengue virus 1


<220> 
<223> dengue virus serotype 1 (DENV-1, NC_001477) Envelope portion of
      polyprotein sequence

<400> 2
Met Arg Cys Val Gly Ile Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      
Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          
Thr Met Ala Lys Asp Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr 
        35                  40                  45              
Glu Val Thr Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala Lys 
    50                  55                  60                  
Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  
Thr Leu Val Glu Glu Gln Asp Thr Asn Phe Val Cys Arg Arg Thr Phe 
                85                  90                  95      
Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         
Leu Ile Thr Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys 
        115                 120                 125             
Ile Val Gln Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His 
    130                 135                 140                 
Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Thr Glu His Gly Thr 
145                 150                 155                 160 
Thr Ala Thr Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu Thr 
                165                 170                 175     
Asp Tyr Gly Ala Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         
Phe Asn Glu Met Val Leu Leu Thr Met Lys Lys Lys Ser Trp Leu Val 
        195                 200                 205             
His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala 
    210                 215                 220                 
Ser Thr Ser Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe 
225                 230                 235                 240 
Lys Thr Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln 
                245                 250                 255     
Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr 
            260                 265                 270         
Ser Gly Thr Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             
Met Asp Lys Leu Ile Leu Lys Gly Met Ser Tyr Val Met Cys Thr Gly 
    290                 295                 300                 
Ser Phe Lys Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val 
305                 310                 315                 320 
Leu Val Gln Val Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro 
                325                 330                 335     
Phe Ser Ser Gln Asp Glu Lys Gly Val Thr Gln Asn Gly Arg Leu Ile 
            340                 345                 350         
Thr Ala Asn Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu 
        355                 360                 365             
Ala Glu Pro Pro Phe Gly Glu Ser Tyr Ile Val Val Gly Ala Gly Glu 
    370                 375                 380                 
Lys Ala Leu Lys Leu Ser Trp Phe Lys Lys Gly 
385                 390                 395 

<210> 3
<211> 395
<212> PRT
<213> Dengue virus 2


<220> 
<223> dengue virus serotype 2 (DENV-2, NC_001474) Envelope portion of
      polyprotein sequence

<400> 3
Met Arg Cys Ile Gly Met Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      
Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          
Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              
Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  
Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  
Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      
Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         
Ile Val Thr Cys Ala Met Phe Arg Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             
Val Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 
Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 
Glu Ile Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     
Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         
Phe Asn Glu Met Val Leu Leu Gln Met Glu Asn Lys Ala Trp Leu Val 
        195                 200                 205             
His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 
Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 
Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     
Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         
Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             
Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 
Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 
Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     
Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         
Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             
Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 
Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly 
385                 390                 395 

<210> 4
<211> 393
<212> PRT
<213> Dengue virus 3


<220> 
<223> dengue virus serotype 3 (DENV-3, NC_001475) Envelope portion of
      polyprotein sequence

<400> 4
Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      
Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          
Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr 
        35                  40                  45              
Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys 
    50                  55                  60                  
Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  
Val Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr 
                85                  90                  95      
Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         
Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Pro Ile Glu Gly Lys 
        115                 120                 125             
Val Val Gln Tyr Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His 
    130                 135                 140                 
Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr Ala 
145                 150                 155                 160 
Glu Ile Thr Pro Gln Ala Ser Thr Thr Glu Ala Ile Leu Pro Glu Tyr 
                165                 170                 175     
Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn 
            180                 185                 190         
Glu Met Ile Leu Leu Thr Met Lys Asn Lys Ala Trp Met Val His Arg 
        195                 200                 205             
Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Ala Ser Gly Ala Thr Thr 
    210                 215                 220                 
Glu Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn 
225                 230                 235                 240 
Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly 
                245                 250                 255     
Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Asn Ser Gly 
            260                 265                 270         
Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp 
        275                 280                 285             
Lys Leu Glu Leu Lys Gly Met Ser Tyr Ala Met Cys Thr Asn Thr Phe 
    290                 295                 300                 
Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile 
305                 310                 315                 320 
Lys Val Glu Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser 
                325                 330                 335     
Thr Glu Asp Gly Gln Gly Lys Ala His Asn Gly Arg Leu Ile Thr Ala 
            340                 345                 350         
Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu 
        355                 360                 365             
Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Asn Ala 
    370                 375                 380                 
Leu Lys Ile Asn Trp Tyr Lys Lys Gly 
385                 390             

<210> 5
<211> 395
<212> PRT
<213> Dengue virus 4


<220> 
<223> dengue virus serotype 4 (DENV-4, NC_002640) Envelope portion of
      polyprotein sequence

<400> 5
Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      
Gly Gly Ala Trp Val Asp Leu Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          
Thr Met Ala Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Thr Lys Thr 
        35                  40                  45              
Thr Ala Lys Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu Ala Ser 
    50                  55                  60                  
Ile Ser Asn Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  
Tyr Leu Lys Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg Asp Val 
                85                  90                  95      
Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         
Val Val Thr Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr Gly Asn 
        115                 120                 125             
Leu Val Gln Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr Val His 
    130                 135                 140                 
Asn Gly Asp Thr His Ala Val Gly Asn Asp Thr Ser Asn His Gly Val 
145                 150                 155                 160 
Thr Ala Met Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys Leu Pro 
                165                 170                 175     
Asp Tyr Gly Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly Ile Asp 
            180                 185                 190         
Phe Asn Glu Met Ile Leu Met Lys Met Lys Lys Lys Thr Trp Leu Val 
        195                 200                 205             
His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ala Gly Ala 
    210                 215                 220                 
Asp Thr Ser Glu Val His Trp Asn Tyr Lys Glu Arg Met Val Thr Phe 
225                 230                 235                 240 
Lys Val Pro His Ala Lys Arg Gln Asp Val Thr Val Leu Gly Ser Gln 
                245                 250                 255     
Glu Gly Ala Met His Ser Ala Leu Ala Gly Ala Thr Glu Val Asp Ser 
            260                 265                 270         
Gly Asp Gly Asn His Met Phe Ala Gly His Leu Lys Cys Lys Val Arg 
        275                 280                 285             
Met Glu Lys Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly 
    290                 295                 300                 
Lys Phe Ser Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr 
305                 310                 315                 320 
Val Val Lys Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys Val Pro 
                325                 330                 335     
Ile Glu Ile Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile 
            340                 345                 350         
Ser Ser Thr Pro Leu Ala Glu Asn Thr Asn Ser Val Thr Asn Ile Glu 
        355                 360                 365             
Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asn 
    370                 375                 380                 
Ser Ala Leu Thr Leu His Trp Phe Arg Lys Gly 
385                 390                 395 

<210> 6
<211> 401
<212> PRT
<213> St. Louis encephalitis virus


<220> 
<223> Saint Louis encephalitis virus (SLEV, NC_007580) Envelope portion
      of polyprotein sequence

<400> 6
Phe Asn Cys Leu Gly Thr Ser Asn Arg Asp Phe Val Glu Gly Ala Ser 
1               5                   10                  15      
Gly Ala Thr Trp Ile Asp Leu Val Leu Glu Gly Gly Ser Cys Val Thr 
            20                  25                  30          
Val Met Ala Pro Glu Lys Pro Thr Leu Asp Phe Lys Val Met Lys Met 
        35                  40                  45              
Glu Ala Thr Glu Leu Ala Thr Val Arg Glu Tyr Cys Tyr Glu Ala Thr 
    50                  55                  60                  
Leu Asp Thr Leu Ser Thr Val Ala Arg Cys Pro Thr Thr Gly Glu Ala 
65                  70                  75                  80  
His Asn Thr Lys Arg Ser Asp Pro Thr Phe Val Cys Lys Arg Asp Val 
                85                  90                  95      
Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         
Ile Asp Thr Cys Ala Lys Phe Thr Cys Lys Asn Lys Ala Thr Gly Lys 
        115                 120                 125             
Thr Ile Leu Arg Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe Val His 
    130                 135                 140                 
Gly Ser Thr Asp Ser Thr Ser His Gly Asn Tyr Ser Glu Gln Ile Gly 
145                 150                 155                 160 
Lys Asn Gln Ala Ala Arg Phe Thr Ile Ser Pro Gln Ala Pro Ser Phe 
                165                 170                 175     
Thr Ala Asn Met Gly Glu Tyr Gly Thr Val Thr Ile Asp Cys Glu Ala 
            180                 185                 190         
Arg Ser Gly Ile Asn Thr Glu Asp Tyr Tyr Val Phe Thr Val Lys Glu 
        195                 200                 205             
Lys Ser Trp Leu Val Asn Arg Asp Trp Phe His Asp Leu Asn Leu Pro 
    210                 215                 220                 
Trp Thr Ser Pro Ala Thr Thr Asp Trp Arg Asn Arg Glu Thr Leu Val 
225                 230                 235                 240 
Glu Phe Glu Glu Pro His Ala Thr Lys Gln Thr Val Val Ala Leu Gly 
                245                 250                 255     
Ser Gln Glu Gly Ala Leu His Thr Ala Leu Ala Gly Ala Ile Pro Ala 
            260                 265                 270         
Thr Val Ser Ser Ser Thr Leu Thr Leu Gln Ser Gly His Leu Lys Cys 
        275                 280                 285             
Arg Ala Lys Leu Asp Lys Val Lys Ile Lys Gly Thr Thr Tyr Gly Met 
    290                 295                 300                 
Cys Asp Ser Ala Phe Thr Phe Ser Lys Asn Pro Thr Asp Thr Gly His 
305                 310                 315                 320 
Gly Thr Val Ile Val Glu Leu Gln Tyr Thr Gly Ser Asn Gly Pro Cys 
                325                 330                 335     
Arg Val Pro Ile Ser Val Thr Ala Asn Leu Met Asp Leu Thr Pro Val 
            340                 345                 350         
Gly Arg Leu Val Thr Val Asn Pro Phe Ile Ser Thr Gly Gly Ala Asn 
        355                 360                 365             
Asn Lys Val Met Ile Glu Val Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    370                 375                 380                 
Val Val Gly Arg Gly Thr Thr Gln Ile Asn Tyr His Trp His Lys Glu 
385                 390                 395                 400 
Gly 
    

<210> 7
<211> 400
<212> PRT
<213> Japanese encephalitis virus


<220> 
<223> Japanese encephalitis virus (JEV, NC_001437) Envelope portion of
      polyprotein sequence

<400> 7
Phe Asn Cys Leu Gly Met Gly Asn Arg Asp Phe Ile Glu Gly Ala Ser 
1               5                   10                  15      
Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Leu Thr 
            20                  25                  30          
Ile Met Ala Asn Asp Lys Pro Thr Leu Asp Val Arg Met Ile Asn Ile 
        35                  40                  45              
Glu Ala Ser Gln Leu Ala Glu Val Arg Ser Tyr Cys Tyr His Ala Ser 
    50                  55                  60                  
Val Thr Asp Ile Ser Thr Val Ala Arg Cys Pro Thr Thr Gly Glu Ala 
65                  70                  75                  80  
His Asn Glu Lys Arg Ala Asp Ser Ser Tyr Val Cys Lys Gln Gly Phe 
                85                  90                  95      
Thr Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         
Ile Asp Thr Cys Ala Lys Phe Ser Cys Thr Ser Lys Ala Ile Gly Arg 
        115                 120                 125             
Thr Ile Gln Pro Glu Asn Ile Lys Tyr Glu Val Gly Ile Phe Val His 
    130                 135                 140                 
Gly Thr Thr Thr Ser Glu Asn His Gly Asn Tyr Ser Ala Gln Val Gly 
145                 150                 155                 160 
Ala Ser Gln Ala Ala Lys Phe Thr Ile Thr Pro Asn Ala Pro Ser Ile 
                165                 170                 175     
Thr Leu Lys Leu Gly Asp Tyr Gly Glu Val Thr Leu Asp Cys Glu Pro 
            180                 185                 190         
Arg Ser Gly Leu Asn Thr Glu Ala Phe Tyr Val Met Thr Val Gly Ser 
        195                 200                 205             
Lys Ser Phe Leu Val His Arg Glu Trp Phe His Asp Leu Ala Leu Pro 
    210                 215                 220                 
Trp Thr Ser Pro Ser Ser Thr Ala Trp Arg Asn Arg Glu Leu Leu Met 
225                 230                 235                 240 
Glu Phe Glu Glu Ala His Ala Thr Lys Gln Ser Val Val Ala Leu Gly 
                245                 250                 255     
Ser Gln Glu Gly Gly Leu His Gln Ala Leu Ala Gly Ala Ile Val Val 
            260                 265                 270         
Glu Tyr Ser Ser Ser Val Lys Leu Thr Ser Gly His Leu Lys Cys Arg 
        275                 280                 285             
Leu Lys Met Asp Lys Leu Ala Leu Lys Gly Thr Thr Tyr Gly Met Cys 
    290                 295                 300                 
Thr Glu Lys Phe Ser Phe Ala Lys Asn Pro Ala Asp Thr Gly His Gly 
305                 310                 315                 320 
Thr Val Val Ile Glu Leu Ser Tyr Ser Gly Ser Asp Gly Pro Cys Lys 
                325                 330                 335     
Ile Pro Ile Val Ser Val Ala Ser Leu Asn Asp Met Thr Pro Val Gly 
            340                 345                 350         
Arg Leu Val Thr Val Asn Pro Phe Val Ala Thr Ser Ser Ala Asn Ser 
        355                 360                 365             
Lys Val Leu Val Glu Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val 
    370                 375                 380                 
Val Gly Arg Gly Asp Lys Gln Ile Asn His His Trp His Lys Ala Gly 
385                 390                 395                 400 



<210> 8
<211> 401
<212> PRT
<213> Murray Valley encephalitis virus


<220> 
<223> Murray Valley encephalitis virus (MVEV, NC_000943) Envelope
      portion of polyprotein sequence

<400> 8
Phe Asn Cys Leu Gly Met Ser Ser Arg Asp Phe Ile Glu Gly Ala Ser 
1               5                   10                  15      
Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Ile Thr 
            20                  25                  30          
Ile Met Ala Ala Asp Lys Pro Thr Leu Asp Ile Arg Met Met Asn Ile 
        35                  40                  45              
Glu Ala Thr Asn Leu Ala Leu Val Arg Asn Tyr Cys Tyr Ala Ala Thr 
    50                  55                  60                  
Val Ser Asp Val Ser Thr Val Ser Asn Cys Pro Thr Thr Gly Glu Ser 
65                  70                  75                  80  
His Asn Thr Lys Arg Ala Asp His Asn Tyr Leu Cys Lys Arg Gly Val 
                85                  90                  95      
Thr Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         
Ile Asp Thr Cys Ala Lys Phe Thr Cys Ser Asn Ser Ala Ala Gly Arg 
        115                 120                 125             
Leu Ile Leu Pro Glu Asp Ile Lys Tyr Glu Val Gly Val Phe Val His 
    130                 135                 140                 
Gly Ser Thr Asp Ser Thr Ser His Gly Asn Tyr Ser Thr Gln Ile Gly 
145                 150                 155                 160 
Ala Asn Gln Ala Val Arg Phe Thr Ile Ser Pro Asn Ala Pro Ala Ile 
                165                 170                 175     
Thr Ala Lys Met Gly Asp Tyr Gly Glu Val Thr Val Glu Cys Glu Pro 
            180                 185                 190         
Arg Ser Gly Leu Asn Thr Glu Ala Tyr Tyr Val Met Thr Ile Gly Thr 
        195                 200                 205             
Lys His Phe Leu Val His Arg Glu Trp Phe Asn Asp Leu Leu Leu Pro 
    210                 215                 220                 
Trp Thr Ser Pro Ala Ser Thr Glu Trp Arg Asn Arg Glu Ile Leu Val 
225                 230                 235                 240 
Glu Phe Glu Glu Pro His Ala Thr Lys Gln Ser Val Val Ala Leu Gly 
                245                 250                 255     
Ser Gln Glu Gly Ala Leu His Gln Ala Leu Ala Gly Ala Ile Pro Val 
            260                 265                 270         
Glu Phe Ser Ser Ser Thr Leu Lys Leu Thr Ser Gly His Leu Lys Cys 
        275                 280                 285             
Arg Val Lys Met Glu Lys Leu Lys Leu Lys Gly Thr Thr Tyr Gly Met 
    290                 295                 300                 
Cys Thr Glu Lys Phe Thr Phe Ser Lys Asn Pro Ala Asp Thr Gly His 
305                 310                 315                 320 
Gly Thr Val Val Leu Glu Leu Gln Tyr Thr Gly Ser Asp Gly Pro Cys 
                325                 330                 335     
Lys Ile Pro Ile Ser Ser Val Ala Ser Leu Asn Asp Met Thr Pro Val 
            340                 345                 350         
Gly Arg Met Val Thr Ala Asn Pro Tyr Val Ala Ser Ser Thr Ala Asn 
        355                 360                 365             
Ala Lys Val Leu Val Glu Ile Glu Pro Pro Phe Gly Asp Ser Tyr Ile 
    370                 375                 380                 
Val Val Gly Arg Gly Asp Lys Gln Ile Asn His His Trp His Lys Glu 
385                 390                 395                 400 
Gly 
    

<210> 9
<211> 397
<212> PRT
<213> West Nile virus


<220> 
<223> West Nile virus (WNV, NC_001563) Envelope portion of polyprotein
      sequence

<400> 9
Phe Asn Cys Leu Gly Met Ser Asn Arg Asp Phe Leu Glu Gly Val Ser 
1               5                   10                  15      
Gly Ala Thr Trp Val Asp Leu Val Leu Glu Gly Asp Ser Cys Val Thr 
            20                  25                  30          
Ile Met Ser Lys Asp Lys Pro Thr Ile Asp Val Lys Met Met Asn Met 
        35                  40                  45              
Glu Ala Ala Asn Leu Ala Asp Val Arg Ser Tyr Cys Tyr Leu Ala Ser 
    50                  55                  60                  
Val Ser Asp Leu Ser Thr Arg Ala Ala Cys Pro Thr Met Gly Glu Ala 
65                  70                  75                  80  
His Asn Glu Lys Arg Ala Asp Pro Ala Phe Val Cys Lys Gln Gly Val 
                85                  90                  95      
Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         
Ile Asp Thr Cys Ala Lys Phe Ala Cys Thr Thr Lys Ala Thr Gly Trp 
        115                 120                 125             
Ile Ile Gln Lys Glu Asn Ile Lys Tyr Glu Val Ala Ile Phe Val His 
    130                 135                 140                 
Gly Pro Thr Thr Val Glu Ser His Gly Lys Ile Gly Ala Thr Gln Ala 
145                 150                 155                 160 
Gly Arg Phe Ser Ile Thr Pro Ser Ala Pro Ser Tyr Thr Leu Lys Leu 
                165                 170                 175     
Gly Glu Tyr Gly Glu Val Thr Val Asp Cys Glu Pro Arg Ser Gly Ile 
            180                 185                 190         
Asp Thr Ser Ala Tyr Tyr Val Met Ser Val Gly Glu Lys Ser Phe Leu 
        195                 200                 205             
Val His Arg Glu Trp Phe Met Asp Leu Asn Leu Pro Trp Ser Ser Ala 
    210                 215                 220                 
Gly Ser Thr Thr Trp Arg Asn Arg Glu Thr Leu Met Glu Phe Glu Glu 
225                 230                 235                 240 
Pro His Ala Thr Lys Gln Ser Val Val Ala Leu Gly Ser Gln Glu Gly 
                245                 250                 255     
Ala Leu His Gln Ala Leu Ala Gly Ala Ile Pro Val Glu Phe Ser Ser 
            260                 265                 270         
Asn Thr Val Lys Leu Thr Ser Gly His Leu Lys Cys Arg Val Lys Met 
        275                 280                 285             
Glu Lys Leu Gln Leu Lys Gly Thr Thr Tyr Gly Val Cys Ser Lys Ala 
    290                 295                 300                 
Phe Lys Phe Ala Arg Thr Pro Ala Asp Thr Gly His Gly Thr Val Val 
305                 310                 315                 320 
Leu Glu Leu Gln Tyr Thr Gly Thr Asp Gly Pro Cys Lys Val Pro Ile 
                325                 330                 335     
Ser Ser Val Ala Ser Leu Asn Asp Leu Thr Pro Val Gly Arg Leu Val 
            340                 345                 350         
Thr Val Asn Pro Phe Val Ser Val Ala Thr Ala Asn Ser Lys Val Leu 
        355                 360                 365             
Ile Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg 
    370                 375                 380                 
Gly Glu Gln Gln Ile Asn His His Trp His Lys Ser Gly 
385                 390                 395         

<210> 10
<211> 395
<212> PRT
<213> Dengue virus 2


<220> 
<223> Envelope ectodomain of the DENV-2 strain used in the structural
      studies described in Example 2, shown in Example 2 ED Figure 7

<400> 10
Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      
Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          
Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              
Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  
Leu Thr Asn Thr Thr Thr Glu Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  
Ser Leu Asn Glu Glu Gln Asp Lys Arg Phe Ile Cys Lys His Ser Met 
                85                  90                  95      
Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         
Ile Val Thr Cys Ala Lys Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             
Ile Val Gln Pro Glu Asn Leu Glu Tyr Thr Ile Val Ile Thr Pro His 
    130                 135                 140                 
Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 
Glu Ile Lys Ile Thr Pro Gln Ser Ser Thr Thr Glu Ala Glu Leu Thr 
                165                 170                 175     
Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         
Phe Asn Glu Met Val Leu Leu Gln Met Glu Asp Lys Ala Trp Leu Val 
        195                 200                 205             
His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 
Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 
Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     
Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         
Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             
Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 
Lys Phe Lys Ile Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 
Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     
Phe Glu Ile Thr Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         
Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             
Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Val Gly Val Glu Pro 
    370                 375                 380                 
Gly Gln Leu Lys Leu Asn Trp Phe Lys Lys Gly 
385                 390                 395 

<210> 11
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 C8 H chain

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Thr Gly Glu Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Phe Glu Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Asn Phe Tyr Tyr Tyr Tyr Thr Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val 
        115                 120 

<210> 12
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 753(3) C10 H chain

<400> 12
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Lys Val Asp Asp Tyr Gly Asp Tyr Trp Phe Pro Thr Leu 
            100                 105                 110         
Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125     

<210> 13
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 C8 L chain

<400> 13
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 14
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 753(3) C10 L chain

<400> 14
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Phe 
            20                  25                  30          
Asn Tyr Val Ser Trp Phe Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Leu Tyr Asp Val Thr Ser Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Thr Ser Arg 
                85                  90                  95      
Gly Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C8 CDR H1

<400> 15
Thr Tyr Ser Met His 
1               5   

<210> 16
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> C8 CDR H2

<400> 16
Ala Ile Thr Gly Glu Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> C8 CDR H3

<400> 17
Gly Tyr Ser Asn Phe Tyr Tyr Tyr 
1               5               

<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> C10 CDR H1

<400> 18
Ser Tyr Ala Met His 
1               5   

<210> 19
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> C10 CDR H2

<400> 19
Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      
Asp 
    

<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> C10 CDR H3

<400> 20
Asp Lys Val Asp Asp Tyr Gly Asp Tyr Trp Phe Pro Thr Leu Trp 
1               5                   10                  15  

<210> 21
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> C8-CDR L1

<400> 21
Arg Ala Ser Gln Ser Ile Ser Thr Phe Leu Ala 
1               5                   10      

<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> C8 CDR L2

<400> 22
Asp Ala Ser Thr Arg Ala Thr 
1               5           

<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> C8 CDR L3

<400> 23
Gln Gln Arg Tyr Asn Trp Pro Pro Tyr Thr 
1               5                   10  

<210> 24
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> C10 CDR L1

<400> 24
Thr Gly Thr Ser Ser Asp Val Gly Gly Phe Asn Tyr Val Ser 
1               5                   10                  

<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> C10 CDR L2

<400> 25
Asp Val Thr Ser Arg Pro Ser 
1               5           

<210> 26
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> C10 CDR L3

<400> 26
Ser Ser His Thr Ser Arg Gly Thr Trp Val Phe 
1               5                   10      

<210> 27
<400> 27
000

<210> 28
<400> 28
000

<210> 29
<400> 29
000

<210> 30
<400> 30
000

<210> 31
<400> 31
000

<210> 32
<400> 32
000

<210> 33
<400> 33
000

<210> 34
<400> 34
000

<210> 35
<400> 35
000

<210> 36
<400> 36
000

<210> 37
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 C8 L chain

<400> 37
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 38
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 753(3) C10 L chain

<400> 38
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Phe 
            20                  25                  30          
Asn Tyr Val Ser Trp Phe Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Leu Tyr Asp Val Thr Ser Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser His Thr Ser Arg 
                85                  90                  95      
Gly Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210> 39
<400> 39
000

<210> 40
<400> 40
000

<210> 41
<400> 41
000

<210> 42
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752 B10 H chain

<400> 42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Thr Thr Asp Gly Asn Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  
Phe His Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Ser Phe Tyr Tyr Tyr Tyr Thr Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 43
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752 B11 H chain

<400> 43
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Thr Thr Asp Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Phe 
65                  70                  75                  80  
Phe His Met Ser Asn Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Ser Phe Tyr Tyr Tyr Tyr Thr Leu Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 44
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752 C9 H chain

<400> 44
Glu Val Gln Leu Val Glu Ser Glu Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Thr Thr Asn Gly Asp Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Phe Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Ser Phe Tyr Tyr Tyr Tyr Thr Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 45
<400> 45
000

<210> 46
<400> 46
000

<210> 47
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) A7 H chain

<400> 47
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Asn 
            20                  25                  30          
Asn Tyr Gln Trp Asn Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Leu Gly Arg Ile Asp Thr Thr Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Ile Ser Ile Ser Ile Asp Thr Ser Lys Lys Gln Phe 
65                  70                  75                  80  
Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Ser Leu Trp Ser Gly Glu Leu Trp Gly Gly Pro Leu Gly 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 

<210> 48
<211> 125
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) A8 H chain

<400> 48
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Asn Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Gly Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Pro Asn Ser Gly Ala Thr Tyr Ser Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Gly Asp Ala Ser Pro Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Gly Arg Ser Tyr Asn Trp Asn Asp Val Phe Tyr Tyr Tyr Tyr Met 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 

<210> 49
<211> 125
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) B10 H chain

<400> 49
Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Ile Ser Gly Val Ser Ile Ser Asp Tyr 
            20                  25                  30          
Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asn Ile Tyr Asn Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Ala Ile Trp Met Asp Thr Ser Lys Asn Lys Phe Ser Leu 
65                  70                  75                  80  
Arg Leu Thr Ser Val Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Val Glu Gly Gly Pro Lys Tyr Tyr Phe Gly Ser Gly Asp Phe Tyr 
            100                 105                 110         
Asn Leu Trp Gly Arg Gly Ser Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 50
<211> 125
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) C2 H chain

<400> 50
Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ser Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Ala Met Ile Asn Pro Thr Ser Gly Ser Thr Ser Tyr Ala Gln Arg Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Pro Thr Asn Thr Val Tyr 
65                  70                  75                  80  
Met Glu Val Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Ser Arg Gly Tyr Asn Trp Asn Asp Val Gln Tyr Tyr Tyr Thr Met 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 

<210> 51
<211> 125
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) D4 H chain

<400> 51
Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Ala Ile Ile Asn Pro Thr Ser Gly Ser Thr Ser Tyr Ala Gln Arg Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Arg Gly Tyr Asn Trp Asn Asp Val His Tyr Tyr Tyr Thr Met 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 

<210> 52
<400> 52
000

<210> 53
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 A2 H chain

<400> 53
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              
Ser Ala Ile Thr Thr Asp Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  
Phe His Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Ser Phe Tyr Tyr Tyr Tyr Thr Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 54
<400> 54
000

<210> 55
<400> 55
000

<210> 56
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 A9 H chain

<400> 56
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Thr Thr Asp Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  
Phe His Met Asn Ser Val Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Ser Phe Tyr Tyr Tyr Tyr Thr Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 57
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 B2 H chain

<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Thr Thr Asp Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  
Phe His Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Ser Phe Tyr Tyr Tyr Tyr Thr Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 58
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 B3 H chain

<400> 58
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Ser Thr Asp Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Phe His Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Leu Gly Gly Tyr Ser Thr Phe Tyr Tyr Tyr Tyr Thr Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 59
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 B4 H chain

<400> 59
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Pro Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Thr Thr Asn Gly Asp Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Phe Gln Leu Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Ser Phe Tyr Phe Tyr Tyr Thr Met Asp Val Trp 
            100                 105                 110         



<210> 60
<400> 60
000

<210> 61
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 B11 H chain

<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Thr Thr Tyr 
            20                  25                  30          
Ser Leu His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Thr Thr Asp Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  
Phe His Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Ser Phe Tyr Tyr Phe Tyr Thr Val Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Phe 
        115                 120         

<210> 62
<211> 125
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 C4 H chain

<400> 62
Ser Gln Val Gln Leu Val Glu Ser Gly Ala Glu Leu Lys Lys Pro Gly 
1               5                   10                  15      
Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Ala Ile Ile Asn Pro Thr Ser Gly Ser Thr Thr Tyr Ala Gln Arg Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Arg Gly Tyr Asn Trp Asn Asp Val His Tyr Tyr Tyr Thr Met 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 

<210> 63
<211> 131
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 753(3) B10 H chain

<400> 63
Glu Val Gln Leu Val Glu Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Asn Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Leu Ile Asn Pro Arg Gly Gly Asn Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Glu Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Asn 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Leu Ala His Thr Tyr Asp Phe Trp Ser Gly Tyr His Arg 
            100                 105                 110         
Ala Thr Gly Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             
Val Ser Ser 
    130     

<210> 64
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6A1 H chain

<400> 64
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Phe Gly Phe Thr Phe Val Asn Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              
Ala Val Ile Tyr Ala Ala Gly Asp Gly Ala Asn Tyr Gly Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Pro Ala His Tyr Asp Asp Ser Gly Tyr Pro Tyr Met Ala Tyr 
            100                 105                 110         
Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     

<210> 65
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6A3 H chain

<400> 65
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Phe Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Asp Tyr Asp Ser Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg His Cys Ser Ser Thr Ser Cys Ser Asp Pro Trp Thr Phe 
            100                 105                 110         
Phe Pro Ser Trp Gly Gln Gly Thr Leu Val Thr Ser Pro Gln 
        115                 120                 125     

<210> 66
<400> 66
000

<210> 67
<211> 130
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6B4 H chain

<400> 67
Glu Val Gln Leu Val Gln Ser Gly Ala Thr Val Arg Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Ala Leu His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Leu Ile Pro Gly Ser Gly Tyr Thr Lys Phe Ala Glu Asn Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Ala Thr Ser Ala His Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Asn Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Trp Gly Gly Asp Cys Asn Ala Gly Ser Cys Tyr Gly Pro Tyr 
            100                 105                 110         
Gln Tyr Arg Gly Leu Asp Ala Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             
Ser Ser 
    130 

<210> 68
<211> 125
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6B5 H chain

<400> 68
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Gly Tyr 
            20                  25                  30          
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Arg Ile Asn Pro Asn Ser Gly Gly Ile Asp Tyr Gly Gln Thr Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Met Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  
Leu Glu Leu Thr Arg Leu Arg Ser Asp Asp Thr Ala Arg Tyr Tyr Cys 
                85                  90                  95      
Ala Gly Arg Ser Asp Asn Trp Asn Asp Val Tyr Tyr Asn Tyr Ala Leu 
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 

<210> 69
<400> 69
000

<210> 70
<211> 128
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6C4 H chain

<400> 70
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ser Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Ala Gln Gly Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Arg Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Lys Leu Arg Ser Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Leu Gly Ala Met Gly Tyr Tyr Leu Cys Ser Ala Gly Asn 
            100                 105                 110         
Cys Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             



<210> 71
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 C8 H chain (page 90)

<400> 71
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              
Ser Ala Ile Thr Gly Glu Gly Asp Ser Ala Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Phe Glu Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Gly Gly Tyr Ser Asn Phe Tyr Tyr Tyr Tyr Thr Met Asp Val Trp 
            100                 105                 110         
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 72
<211> 128
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 753(3) C10 H chain (page 90)

<400> 72
Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Asp Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Lys Val Asp Asp Tyr Gly Asp Tyr Trp Phe Pro Thr Leu 
            100                 105                 110         
Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             



<210> 73
<400> 73
000

<210> 74
<400> 74
000

<210> 75
<400> 75
000

<210> 76
<400> 76
000

<210> 77
<400> 77
000

<210> 78
<400> 78
000

<210> 79
<400> 79
000

<210> 80
<400> 80
000

<210> 81
<400> 81
000

<210> 82
<400> 82
000

<210> 83
<400> 83
000

<210> 84
<400> 84
000

<210> 85
<400> 85
000

<210> 86
<400> 86
000

<210> 87
<400> 87
000

<210> 88
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752 B10 L chain

<400> 88
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ala Gly 
1               5                   10                  15      
Asp Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Ser Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Met 
        35                  40                  45              
Tyr Asp Thr Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Val Ala Val Tyr Tyr Cys Gln His Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 89
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752 B11 L chain

<400> 89
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Val Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 90
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752 C9 L chain

<400> 90
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 91
<400> 91
000

<210> 92
<400> 92
000

<210> 93
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) A7 L chain

<400> 93
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Val Ser Thr Phe 
            20                  25                  30          
Val Ala Trp Phe Gln Gln Asn Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Thr Arg Ala Pro Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Trp Pro Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 94
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) A8 L chain

<400> 94
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Ala Ser 
            20                  25                  30          
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Arg Ala Ser Asn Leu Glu Gly Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ala Asn Ser Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 95
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) B10 L chain

<400> 95
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Ser Val Thr Val Ala Cys Arg Ala Ser Gln Pro Ile Tyr Arg Asn 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 96
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) C2 L chain

<400> 96
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Glu Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Asp Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Ser Pro 
                85                  90                  95      
Pro Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 

<210> 97
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752(2) D4 L chain

<400> 97
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Leu Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Asp Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Ser Pro 
                85                  90                  95      
Pro Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 

<210> 98
<400> 98
000

<210> 99
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 A2 L chain

<400> 99
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ala Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gln Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Leu Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 100
<400> 100
000

<210> 101
<400> 101
000

<210> 102
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 A9 L chain

<400> 102
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ala Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Thr Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Thr Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 103
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 B2 L chain

<400> 103
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Ala Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 104
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 B3 L chain

<400> 104
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser His Ser Ile Ser Thr Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Thr Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 105
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 B4 L chain

<400> 105
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Thr Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Ile Tyr Tyr Cys Gln His Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 106
<400> 106
000

<210> 107
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 B11 L chain

<400> 107
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          
Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Thr Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Thr Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg Tyr Asn Trp Pro Pro 
                85                  90                  95      
Tyr Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 108
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 752-2 C4 L chain

<400> 108
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Val Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Glu Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Ser Pro 
                85                  90                  95      
Pro Val Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 

<210> 109
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 753(3) B10 L chain

<400> 109
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          
Asp Gly Asn Lys Tyr Leu Asp Trp Tyr Val Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Leu Thr Ser Thr Arg Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Ala Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      
Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         



<210> 110
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6A1 L chain

<400> 110
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Thr Cys Arg Ala Ser Gln Thr Ile Ser Thr Phe 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Thr Ser Thr Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser Gly 
    50                  55                  60                  
Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Val Ala Val Tyr Tyr Cys Gln His Tyr Tyr Asn Trp Pro Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 111
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6A3 L chain

<400> 111
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asp Ile Gly Gly Asn 
            20                  25                  30          
Glu Tyr Val Ser Trp Tyr Gln Leu Gln Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Pro Asn Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  
Gln Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Tyr Ala Asp Asn 
                85                  90                  95      
Ser Val Leu Phe Gly Gly Gly Thr Thr Leu Thr Val Leu 
            100                 105                 

<210> 112
<400> 112
000

<210> 113
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6B4 L chain

<400> 113
Glu Ile Val Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Asp Ser Thr 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Asn Arg Ala Ile Gly Val Pro Ser Arg Phe Thr 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Ser Asp Gly Ser Leu 
                85                  90                  95      
Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             

<210> 114
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6B5 L chain

<400> 114
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ala Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         

<210> 115
<400> 115
000

<210> 116
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE1 758 P6C4 L chain

<400> 116
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          
Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Ile Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro His Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Glu Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      
Asn Thr Phe Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210> 117
<400> 117
000

<210> 118
<400> 118
000

<210> 119
<400> 119
000

<210> 120
<211> 131
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE2 A11 vH (Example 2 ED Figure 3)

<400> 120
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Tyr Ser Asn His 
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              
Ser Arg Ile Asn Ser Asp Gly Ser Thr Arg Asn Tyr Ala Asp Phe Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Glu Met Asn Ser Leu Thr Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Asp Gly Val Arg Phe Tyr Tyr Asp Ser Thr Gly Tyr Tyr Pro 
            100                 105                 110         
Asp Ser Phe Phe Lys Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             
Val Thr Val 
    130     

<210> 121
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> Antibody EDE2 A11 vL (Example 2 ED Figure 3)

<400> 121
Gln Ser Val Leu Thr Gln Pro Val Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Ala Asp Thr Tyr 
            20                  25                  30          
Asn Leu Val Ser Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Glu Gly Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  
Ser Ala Ser Lys Ser Ala Thr Ala Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Thr Ser 
                85                  90                  95      
Arg Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Val 
            100                 105                 110 

<210> 122
<400> 122
000

<210> 123
<400> 123
000

<210> 124
<400> 124
000

<210> 125
<400> 125
000

<210> 126
<400> 126
000

<210> 127
<400> 127
000

<210> 128
<400> 128
000

<210> 129
<400> 129
000

<210> 130
<400> 130
000

<210> 131
<400> 131
000

<210> 132
<400> 132
000

<210> 133
<400> 133
000

<210> 134
<400> 134
000

<210> 135
<400> 135
000

<210> 136
<400> 136
000

<210> 137
<400> 137
000

<210> 138
<400> 138
000

<210> 139
<400> 139
000

<210> 140
<400> 140
000

<210> 141
<400> 141
000

<210> 142
<400> 142
000

<210> 143
<400> 143
000

<210> 144
<400> 144
000

<210> 145
<400> 145
000

<210> 146
<400> 146
000

<210> 147
<400> 147
000

<210> 148
<211> 12
<212> PRT
<213> Dengue virus 1


<220> 
<223> 150 loop of Denv-1

<400> 148
Gln His Gln Val Gly Asn Glu Thr Thr Glu His Gly 
1               5                   10          

<210> 149
<211> 12
<212> PRT
<213> Dengue virus 2


<220> 
<223> 150 loop of Denv 2

<400> 149
Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly 
1               5                   10          

<210> 150
<211> 10
<212> PRT
<213> Dengue virus 3


<220> 
<223> 150 loop of Denv 3

<400> 150
Gln His Gln Val Gly Asn Glu Thr Gln Gly 
1               5                   10  

<210> 151
<211> 12
<212> PRT
<213> Dengue virus 4


<220> 
<223> 150 loop of Denv 4

<400> 151
Thr His Ala Val Gly Asn Asp Ile Pro Asn His Gly 
1               5                   10          

