                         SEQUENCE LISTING

<110>  Oxford Genetics Limited
 
<120>  Methods

<130>  489.412.128754/01

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Human immunodeficiency virus

<400>  1

Phe Leu Asp Gly Ile Asp Lys Ala Gln Asp Glu His Glu Lys Tyr His 
1               5                   10                  15      


Ser Asn Trp Arg Ala Met Ala Ser Asp Phe Asn Leu Pro Pro Val Val 
            20                  25                  30          


Ala Lys Glu Ile Val Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu 
        35                  40                  45              


Ala Met His Gly Gln Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Asp 
    50                  55                  60                  


Cys Thr His Leu Glu Gly Lys Val Ile Leu Val Ala Val His Val Ala 
65                  70                  75                  80  


Ser Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu Thr Gly Gln Glu 
                85                  90                  95      


Thr Ala Tyr Phe Leu Leu Lys Leu Ala Gly Arg Trp Pro Val Lys Thr 
            100                 105                 110         


Ile His Thr Asp Asn Gly Ser Asn Phe Thr Gly Ala Thr Val Arg Ala 
        115                 120                 125             


Ala Cys Trp Trp Ala Gly Ile Lys Gln Glu Phe Gly Ile Pro Tyr Asn 
    130                 135                 140                 


Pro Gln Ser Gln Gly Val Val Glu Ser Met Asn Lys Glu Leu Lys Lys 
145                 150                 155                 160 


Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His Leu Lys Thr Ala Val 
                165                 170                 175     


Gln Met Ala Val Phe Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly 
            180                 185                 190         


Gly Tyr Ser Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile 
        195                 200                 205             


Gln Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg 
    210                 215                 220                 


Val Tyr Tyr Arg Asp Ser Arg Asn Pro Leu Trp Lys Gly Pro Ala Lys 
225                 230                 235                 240 


Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn Ser Asp 
                245                 250                 255     


Ile Lys Val Val Pro Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly 
            260                 265                 270         


Lys Gln Met Ala Gly Asp Asp Cys Val Ala Ser Arg Gln Asp Glu Asp 
        275                 280                 285             


<210>  2
<211>  800
<212>  DNA
<213>  Human immunodeficiency virus

<400>  2
tagtcagtgc tggaatcagg aaagtactat ttttagatgg aatagataag gcccaagatg       60

aacatgagaa atatcacagt aattggagag caatggctag tgattttaac ctgccacctg      120

tagtagcaaa agaaatagta gccagctgtg ataaatgtca gctaaaagga gaagccatgc      180

atggacaagt agactgtagt ccaggaatat ggcaactaga ttgtacacat ttagaaggaa      240

aagttatcct ggtagcagtt catgtagcca gtggatatat agaagcagaa gttattccag      300

cagaaacagg gcaggaaaca gcatattttc ttttaaaatt agcaggaaga tggccagtaa      360

aaacaataca tactgacaat ggcagcaatt tcaccggtgc tacggttagg gccgcctgtt      420

ggtgggcggg aatcaagcag gaatttggaa ttccctacaa tccccaaagt caaggagtag      480

tagaatctat gaataaagaa ttaaagaaaa ttataggaca ggtaagagat caggctgaac      540

atcttaagac agcagtacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga      600

ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta      660

aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca      720

gaaatccact ttggaaagga ccagcaaagc tcctctggaa aggtgaaggg gcagtagtaa      780

tacaagataa tagtgacata                                                  800


<210>  3
<211>  1379
<212>  PRT
<213>  Streptococcus pyogenes

<400>  3

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val 
    1370                 1375                 


<210>  4
<211>  1379
<212>  PRT
<213>  Streptococcus pyogenes

<400>  4

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val 
    1370                 1375                 


<210>  5
<211>  1379
<212>  PRT
<213>  Streptococcus pyogenes

<400>  5

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val 
    1370                 1375                 


<210>  6
<211>  1457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  6

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Ser Arg  Ala Asp Pro Lys Lys  Lys Arg Lys Val Val  Glu Lys Lys 
    1370                 1375                 1380             


Arg Glu  Thr Ser Met Asp Ser  Arg Leu Gln Arg Ile  His Ala Glu 
    1385                 1390                 1395             


Ile Lys  Asn Ser Leu Lys Ile  Asp Asn Leu Asp Val  Asn Arg Cys 
    1400                 1405                 1410             


Ile Glu  Ala Leu Asp Glu Leu  Ala Ser Leu Gln Val  Thr Met Gln 
    1415                 1420                 1425             


Gln Ala  Gln Lys His Thr Glu  Met Ile Thr Thr Leu  Lys Lys Ile 
    1430                 1435                 1440             


Arg Arg  Phe Lys Val Ser Gln  Val Ile Met Glu Lys  Ser Thr 
    1445                 1450                 1455         


<210>  7
<211>  1457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion polypeptide

<400>  7

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Val Glu  Lys Lys Arg Glu Thr  Ser Met Asp Ser Arg  Leu Gln Arg 
    1370                 1375                 1380             


Ile His  Ala Glu Ile Lys Asn  Ser Leu Lys Ile Asp  Asn Leu Asp 
    1385                 1390                 1395             


Val Asn  Arg Cys Ile Glu Ala  Leu Asp Glu Leu Ala  Ser Leu Gln 
    1400                 1405                 1410             


Val Thr  Met Gln Gln Ala Gln  Lys His Thr Glu Met  Ile Thr Thr 
    1415                 1420                 1425             


Leu Lys  Lys Ile Arg Arg Phe  Lys Val Ser Gln Val  Ile Met Glu 
    1430                 1435                 1440             


Lys Ser  Thr Ser Arg Ala Asp  Pro Lys Lys Lys Arg  Lys Val 
    1445                 1450                 1455         


<210>  8
<211>  8350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector

<400>  8
gcgatcgcgg ctcccgacat cttggaccat tagctccaca ggtatcttct tccctctagt       60

ggtcataaca gcagcttcag ctacctctca attcaaaaaa cccctcaaga cccgtttaga      120

ggccccaagg ggttatgcta tcaatcgttg cgttacacac acaaaaaacc aacacacatc      180

catcttcgat ggatagcgat tttattatct aactgctgat cgagtgtagc cagatctagt      240

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta      300

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga      360

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      420

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta      480

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg      540

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg ctgatgcggt      600

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      660

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      720

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      780

atataagcag agctggttta gtgaaccgtc agatcagatc tttgtcgatc ctaccatcca      840

ctcgacacac ccgccagcgg ccgctgccaa gcttccgagc tctcgaattc aaaggaggta      900

cccaccatgg ataagaaata ctcaatcgga ctggccatcg gcactaattc ggtgggatgg      960

gcagtgatta ccgatgagta caaggtcccg tcgaagaagt ttaaggtgct gggaaacacc     1020

gatagacact cgatcaagaa gaacctcatc ggcgctctgc tgtttgattc cggcgagact     1080

gcggaagcca cccggctgaa gcgcactgcc cgcagaagat acacccggcg gaaaaataga     1140

atctgctacc tccaggagat tttctcgaac gaaatggcaa aggtggacga ttcattcttc     1200

catcgcctgg aagagagctt cctggtggaa gaggataaga agcatgagcg ccatcctatc     1260

ttcgggaaca ttgtggacga agtggcctat cacgagaaat acccgactat ctatcatctc     1320

cgcaagaagc tggtggactc aaccgataag gccgacctga ggctgatcta cctggcactg     1380

gcacatatga ttaaattccg gggccatttc cttatcgagg gggatctgaa tccggataac     1440

tccgatgtcg ataagctgtt catccagctg gtccagactt acaatcagct gttcgaggaa     1500

aatccgatca atgcgtcggg cgtggacgcc aaggccatcc tctcggcgag gctgtcaaaa     1560

agcaggcgcc tcgaaaacct gatcgcgcag ctgccggggg aaaaaaagaa cggcctgttt     1620

gggaatctga tcgccctctc actgggacta accccgaatt tcaagtcgaa tttcgatctc     1680

gcagaagacg ccaagctgca attgtccaag gatacctacg acgatgatct ggataatcta     1740

ctggctcaga tcggagatca gtacgcggac ctgttcttgg ccgctaagaa cctctcggac     1800

gccattctgc tgagcgacat cctgcgcgtc aatactgaga tcaccaaagc gccactgagc     1860

gcgtcgatga ttaagagata cgacgaacat catcaggatc tgactctgct gaaggccctc     1920

gtccgccagc agctcccgga aaagtacaag gagattttct ttgaccagtc gaagaatggc     1980

tacgcaggct atatcgacgg aggcgccagc caagaagagt tttacaagtt catcaagcca     2040

atcctggaga agatggacgg cactgaggaa ctgctcgtga agctgaaccg ggaggacttg     2100

ctgagaaaac agagaacctt cgacaatgga agcatcccgc accagatcca tctcggggaa     2160

ctgcatgcta ttctgagaag gcaagaggat ttctacccct ttctgaagga taacagagaa     2220

aagatcgaaa agattttgac cttccgcatc ccatactacg tggggcctct agccaggggc     2280

aacagccggt ttgcatggat gacccgcaag tcggaggaaa cgatcactcc gtggaacttc     2340

gaggaagtgg tggacaaagg agcgtcagct cagtccttta tcgaacgcat gacgaacttc     2400

gataagaatc tcccaaacga aaaggtgctt ccaaagcatt cgctgctcta cgaatacttc     2460

accgtgtaca acgaactcac taaggtgaag tacgtcactg aagggatgcg caagccggca     2520

tttctgtcgg gagagcaaaa gaaagcaatc gtggacctgc tgttcaagac caacagaaag     2580

gtgactgtca agcagttgaa agaagattat ttcaaaaaaa tcgaatgttt tgatagcgtg     2640

gaaatctccg gtgtggagga cagatttaat gcttcactgg gcacttacca cgacctgctc     2700

aaaatcatca aagacaaaga tttcctcgat aacgaggaaa acgaggacat cctggaggac     2760

attgtgctga cgctgactct gttcgaggat cgcgagatga tcgaggaacg cctgaagact     2820

tatgcccatc tcttcgacga caaggtgatg aaacagctca aacgccggag atacaccgga     2880

tggggacggc tgtcgagaaa actgattaac ggaatcaggg ataaacaatc gggcaaaact     2940

atcctggact ttctaaagtc agatgggttc gcaaaccgga atttcatgca gctcatccac     3000

gacgactcct tgactttcaa ggaggatatt cagaaagccc aagtctccgg acagggagac     3060

tccctgcatg agcacatcgc gaatctggca ggatcgcccg caattaagaa gggcattctc     3120

cagactgtga aggtcgtgga cgaactggtc aaagtcatgg gacgccataa gccagagaac     3180

atcgtgatcg agatggcgcg ggaaaaccag accactcaga aggggcagaa gaacagcaga     3240

gaaagaatga aacgcatcga agaaggcatc aaggaactcg gaagccaaat cctcaaggaa     3300

catccggtcg agaatactca gctacagaat gagaagctct acctgtacta cctgcaaaat     3360

ggtcgggata tgtacgtcga tcaagaacta gacatcaaca ggctgtcgga ttacgatgtg     3420

gacgccatcg tgccccaatc attcctgaag gacgattcga ttgataataa ggtgctcact     3480

agatcagaca aaaacagagg aaaatcggac aacgtgccgt cagaagaggt ggtgaagaag     3540

atgaagaatt actggcgcca actgctgaac gcaaagctga ttacccagag aaaattcgac     3600

aatttgacca aggcagagcg cggaggtctg tcagagcttg acaaggcggg gtttatcaag     3660

aggcaactgg tcgaaacccg ccagatcact aaacacgtgg cgcagatcct cgactccaga     3720

atgaacacta agtacgacga aaatgataaa ttgatccggg aagtcaaggt gattaccctg     3780

aaatcaaaac tggtgtcaga ttttcgcaag gacttccaat tctacaaggt cagggagatc     3840

aacaattacc accatgccca cgatgcctac ctgaacgcgg tggtgggcac tgcgctcatc     3900

aagaagtacc caaaactgga atcggagttc gtgtacggag attacaaggt gtacgacgtg     3960

cgcaaaatga tcgctaagtc agagcaggaa atcggaaaag ccaccgcgaa atacttcttc     4020

tactcgaaca ttatgaattt tttcaaaact gagattactc ttgcgaacgg cgagatccgc     4080

aaacgcccct tgatcgaaac taatggggaa accggcgaaa tcgtctggga taagggcagg     4140

gatttcgcta ccgtcaggaa ggtgctgtca atgccgcaag tgaatatcgt gaaaaaaacc     4200

gaagtccaaa ccggaggttt cagcaaagag tccatcctgc ccaagcgcaa ctcggataag     4260

ctcattgcta ggaagaaaga ttgggacccc aagaaatacg gcgggttcga ctcgccgacc     4320

gtggcatact ccgtgctggt ggtggccaag gtcgaaaaag gaaaatcaaa gaagctgaaa     4380

tccgtgaagg aattgctggg aatcactatc atggagcggt cctcctttga aaagaatcca     4440

attgactttc tggaagcaaa gggctacaag gaggtgaaaa aggacctgat tatcaaactt     4500

ccaaagtact cactctttga gctggaaaac ggtagaaaga gaatgctggc gagcgctgga     4560

gagctgcaga agggaaatga actggcactg ccgtcgaagt acgtgaattt tctttatctg     4620

gcatcacact acgaaaaact caaaggttca cctgaagata atgagcaaaa gcagctattt     4680

gtcgaacaac acaagcatta cttggacgaa atcatcgaac agatttcgga attttcaaag     4740

agagtgatcc tggcggatgc caatctggac aaggtgctct cggcgtacaa caagcatcgc     4800

gacaagccga tccgcgagca agcagagaat atcatccacc tgttcaccct aacgaacctg     4860

ggagcgccgg cggccttcaa atatttcgac accactatcg accggaaacg gtacacctca     4920

accaaggaag tgctcgacgc aaccctgatc catcagtcca tcaccggcct ctatgaaacc     4980

cggatcgacc tgtcacagct cggcggtgac tcgcgggctg acccgaaaaa gaagagaaag     5040

gtctagaagt tgtctcctcc tgcactgact gactgataca atcgatttct ggatccgcag     5100

gcctctgcta gcttgactga ctgagataca gcgtaccttc agctcacaga catgataaga     5160

tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt     5220

gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac     5280

aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa     5340

agcaagtaaa acctctacaa atgtggtatt ggcccatctc tatcggtatc gtagcataac     5400

cccttggggc ctctaaacgg gtcttgaggg gttttttgtg cccctcgggc cggattgcta     5460

tctaccggca ttggcgcaga aaaaaatgcc tgatgcgacg ctgcgcgtct tatactccca     5520

catatgccag attcagcaac ggatacggct tccccaactt gcccacttcc atacgtgtcc     5580

tccttaccag aaatttatcc ttaaggtcgt cagctatcct gcaggcgatc tctcgatttc     5640

gatcaagaca ttcctttaat ggtcttttct ggacaccact aggggtcaga agtagttcat     5700

caaactttct tccctcccta atctcattgg ttaccttggg ctatcgaaac ttaattaacc     5760

agtcaagtca gctacttggc gagatcgact tgtctgggtt tcgactacgc tcagaattgc     5820

gtcagtcaag ttcgatctgg tccttgctat tgcacccgtt ctccgattac gagtttcatt     5880

taaatcatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     5940

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     6000

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     6060

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     6120

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     6180

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     6240

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     6300

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     6360

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     6420

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     6480

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     6540

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     6600

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     6660

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     6720

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc atttaaattt     6780

ccgaactctc caaggccctc gtcggaaaat cttcaaacct ttcgtccgat ccatcttgca     6840

ggctacctct cgaacgaact atcgcaagtc tcttggccgg ccttgcgcct tggctattgc     6900

ttggcagcgc ctatcgccag gtattactcc aatcccgaat atccgagatc gggatcaccc     6960

gagagaagtt caacctacat cctcaatccc gatctatccg agatccgagg aatatcgaaa     7020

tcggggcgcg cctggtgtac cgagaacgat cctctcagtg cgagtctcga cgatccatat     7080

cgttgcttgg cagtcagcca gtcggaatcc agcttgggac ccaggaagtc caatcgtcag     7140

atattgtact caagcctggt cacggcagcg taccgatctg tttaaaccta gatattgata     7200

gtctgatcgg tcaacgtata atcgagtcct agcttttgca aacatctatc aagagacagg     7260

atcagcagga ggctttcgca tgattgaaca agatggattg cacgcaggtt ctccggcggc     7320

ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc     7380

cgccgtgttc cggctgtcag cgcaggggcg tccggttctt tttgtcaaga ccgacctgtc     7440

cggtgccctg aatgaactgc aagacgaggc agcgcggcta tcgtggctgg cgacgacggg     7500

cgttccttgc gcggctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt     7560

gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc     7620

catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga     7680

ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga     7740

tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct     7800

caaggcgtct atgcccgacg gcgaggatct cgtcgtgacc cacggcgatg cctgcttgcc     7860

gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc gtctgggtgt     7920

ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg     7980

cgaatgggct gaccgcttcc ttgtgcttta cggtatcgcc gcgcccgatt cgcagcgcat     8040

cgccttctat cgccttcttg acgagttctt ctgaccgatt ctaggtgcat tggcgcagaa     8100

aaaaatgcct gatgcgacgc tgcgcgtctt atactcccac atatgccaga ttcagcaacg     8160

gatacggctt ccccaacttg cccacttcca tacgtgtcct ccttaccaga aatttatcct     8220

taaggtcgtt taaactcgac tctggctcta tcgaatctcc gtcgtttcga gcttacgcga     8280

acagccgtgg cgctcatttg ctcgtcgggc atcgaatctc gtcagctatc gtcagcttac     8340

ctttttggca                                                            8350


<210>  9
<211>  4140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector

<400>  9
atggataaga aatactcaat cggactggcc atcggcacta attcggtggg atgggcagtg       60

attaccgatg agtacaaggt cccgtcgaag aagtttaagg tgctgggaaa caccgataga      120

cactcgatca agaagaacct catcggcgct ctgctgtttg attccggcga gactgcggaa      180

gccacccggc tgaagcgcac tgcccgcaga agatacaccc ggcggaaaaa tagaatctgc      240

tacctccagg agattttctc gaacgaaatg gcaaaggtgg acgattcatt cttccatcgc      300

ctggaagaga gcttcctggt ggaagaggat aagaagcatg agcgccatcc tatcttcggg      360

aacattgtgg acgaagtggc ctatcacgag aaatacccga ctatctatca tctccgcaag      420

aagctggtgg actcaaccga taaggccgac ctgaggctga tctacctggc actggcacat      480

atgattaaat tccggggcca tttccttatc gagggggatc tgaatccgga taactccgat      540

gtcgataagc tgttcatcca gctggtccag acttacaatc agctgttcga ggaaaatccg      600

atcaatgcgt cgggcgtgga cgccaaggcc atcctctcgg cgaggctgtc aaaaagcagg      660

cgcctcgaaa acctgatcgc gcagctgccg ggggaaaaaa agaacggcct gtttgggaat      720

ctgatcgccc tctcactggg actaaccccg aatttcaagt cgaatttcga tctcgcagaa      780

gacgccaagc tgcaattgtc caaggatacc tacgacgatg atctggataa tctactggct      840

cagatcggag atcagtacgc ggacctgttc ttggccgcta agaacctctc ggacgccatt      900

ctgctgagcg acatcctgcg cgtcaatact gagatcacca aagcgccact gagcgcgtcg      960

atgattaaga gatacgacga acatcatcag gatctgactc tgctgaaggc cctcgtccgc     1020

cagcagctcc cggaaaagta caaggagatt ttctttgacc agtcgaagaa tggctacgca     1080

ggctatatcg acggaggcgc cagccaagaa gagttttaca agttcatcaa gccaatcctg     1140

gagaagatgg acggcactga ggaactgctc gtgaagctga accgggagga cttgctgaga     1200

aaacagagaa ccttcgacaa tggaagcatc ccgcaccaga tccatctcgg ggaactgcat     1260

gctattctga gaaggcaaga ggatttctac ccctttctga aggataacag agaaaagatc     1320

gaaaagattt tgaccttccg catcccatac tacgtggggc ctctagccag gggcaacagc     1380

cggtttgcat ggatgacccg caagtcggag gaaacgatca ctccgtggaa cttcgaggaa     1440

gtggtggaca aaggagcgtc agctcagtcc tttatcgaac gcatgacgaa cttcgataag     1500

aatctcccaa acgaaaaggt gcttccaaag cattcgctgc tctacgaata cttcaccgtg     1560

tacaacgaac tcactaaggt gaagtacgtc actgaaggga tgcgcaagcc ggcatttctg     1620

tcgggagagc aaaagaaagc aatcgtggac ctgctgttca agaccaacag aaaggtgact     1680

gtcaagcagt tgaaagaaga ttatttcaaa aaaatcgaat gttttgatag cgtggaaatc     1740

tccggtgtgg aggacagatt taatgcttca ctgggcactt accacgacct gctcaaaatc     1800

atcaaagaca aagatttcct cgataacgag gaaaacgagg acatcctgga ggacattgtg     1860

ctgacgctga ctctgttcga ggatcgcgag atgatcgagg aacgcctgaa gacttatgcc     1920

catctcttcg acgacaaggt gatgaaacag ctcaaacgcc ggagatacac cggatgggga     1980

cggctgtcga gaaaactgat taacggaatc agggataaac aatcgggcaa aactatcctg     2040

gactttctaa agtcagatgg gttcgcaaac cggaatttca tgcagctcat ccacgacgac     2100

tccttgactt tcaaggagga tattcagaaa gcccaagtct ccggacaggg agactccctg     2160

catgagcaca tcgcgaatct ggcaggatcg cccgcaatta agaagggcat tctccagact     2220

gtgaaggtcg tggacgaact ggtcaaagtc atgggacgcc ataagccaga gaacatcgtg     2280

atcgagatgg cgcgggaaaa ccagaccact cagaaggggc agaagaacag cagagaaaga     2340

atgaaacgca tcgaagaagg catcaaggaa ctcggaagcc aaatcctcaa ggaacatccg     2400

gtcgagaata ctcagctaca gaatgagaag ctctacctgt actacctgca aaatggtcgg     2460

gatatgtacg tcgatcaaga actagacatc aacaggctgt cggattacga tgtggacgcc     2520

atcgtgcccc aatcattcct gaaggacgat tcgattgata ataaggtgct cactagatca     2580

gacaaaaaca gaggaaaatc ggacaacgtg ccgtcagaag aggtggtgaa gaagatgaag     2640

aattactggc gccaactgct gaacgcaaag ctgattaccc agagaaaatt cgacaatttg     2700

accaaggcag agcgcggagg tctgtcagag cttgacaagg cggggtttat caagaggcaa     2760

ctggtcgaaa cccgccagat cactaaacac gtggcgcaga tcctcgactc cagaatgaac     2820

actaagtacg acgaaaatga taaattgatc cgggaagtca aggtgattac cctgaaatca     2880

aaactggtgt cagattttcg caaggacttc caattctaca aggtcaggga gatcaacaat     2940

taccaccatg cccacgatgc ctacctgaac gcggtggtgg gcactgcgct catcaagaag     3000

tacccaaaac tggaatcgga gttcgtgtac ggagattaca aggtgtacga cgtgcgcaaa     3060

atgatcgcta agtcagagca ggaaatcgga aaagccaccg cgaaatactt cttctactcg     3120

aacattatga attttttcaa aactgagatt actcttgcga acggcgagat ccgcaaacgc     3180

cccttgatcg aaactaatgg ggaaaccggc gaaatcgtct gggataaggg cagggatttc     3240

gctaccgtca ggaaggtgct gtcaatgccg caagtgaata tcgtgaaaaa aaccgaagtc     3300

caaaccggag gtttcagcaa agagtccatc ctgcccaagc gcaactcgga taagctcatt     3360

gctaggaaga aagattggga ccccaagaaa tacggcgggt tcgactcgcc gaccgtggca     3420

tactccgtgc tggtggtggc caaggtcgaa aaaggaaaat caaagaagct gaaatccgtg     3480

aaggaattgc tgggaatcac tatcatggag cggtcctcct ttgaaaagaa tccaattgac     3540

tttctggaag caaagggcta caaggaggtg aaaaaggacc tgattatcaa acttccaaag     3600

tactcactct ttgagctgga aaacggtaga aagagaatgc tggcgagcgc tggagagctg     3660

cagaagggaa atgaactggc actgccgtcg aagtacgtga attttcttta tctggcatca     3720

cactacgaaa aactcaaagg ttcacctgaa gataatgagc aaaagcagct atttgtcgaa     3780

caacacaagc attacttgga cgaaatcatc gaacagattt cggaattttc aaagagagtg     3840

atcctggcgg atgccaatct ggacaaggtg ctctcggcgt acaacaagca tcgcgacaag     3900

ccgatccgcg agcaagcaga gaatatcatc cacctgttca ccctaacgaa cctgggagcg     3960

ccggcggcct tcaaatattt cgacaccact atcgaccgga aacggtacac ctcaaccaag     4020

gaagtgctcg acgcaaccct gatccatcag tccatcaccg gcctctatga aacccggatc     4080

gacctgtcac agctcggcgg tgactcgcgg gctgacccga aaaagaagag aaaggtctag     4140


<210>  10
<211>  4377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector

<400>  10
atggataaga aatactcaat cggactggcc atcggcacta attcggtggg atgggcagtg       60

attaccgatg agtacaaggt cccgtcgaag aagtttaagg tgctgggaaa caccgataga      120

cactcgatca agaagaacct catcggcgct ctgctgtttg attccggcga gactgcggaa      180

gccacccggc tgaagcgcac tgcccgcaga agatacaccc ggcggaaaaa tagaatctgc      240

tacctccagg agattttctc gaacgaaatg gcaaaggtgg acgattcatt cttccatcgc      300

ctggaagaga gcttcctggt ggaagaggat aagaagcatg agcgccatcc tatcttcggg      360

aacattgtgg acgaagtggc ctatcacgag aaatacccga ctatctatca tctccgcaag      420

aagctggtgg actcaaccga taaggccgac ctgaggctga tctacctggc actggcacat      480

atgattaaat tccggggcca tttccttatc gagggggatc tgaatccgga taactccgat      540

gtcgataagc tgttcatcca gctggtccag acttacaatc agctgttcga ggaaaatccg      600

atcaatgcgt cgggcgtgga cgccaaggcc atcctctcgg cgaggctgtc aaaaagcagg      660

cgcctcgaaa acctgatcgc gcagctgccg ggggaaaaaa agaacggcct gtttgggaat      720

ctgatcgccc tctcactggg actaaccccg aatttcaagt cgaatttcga tctcgcagaa      780

gacgccaagc tgcaattgtc caaggatacc tacgacgatg atctggataa tctactggct      840

cagatcggag atcagtacgc ggacctgttc ttggccgcta agaacctctc ggacgccatt      900

ctgctgagcg acatcctgcg cgtcaatact gagatcacca aagcgccact gagcgcgtcg      960

atgattaaga gatacgacga acatcatcag gatctgactc tgctgaaggc cctcgtccgc     1020

cagcagctcc cggaaaagta caaggagatt ttctttgacc agtcgaagaa tggctacgca     1080

ggctatatcg acggaggcgc cagccaagaa gagttttaca agttcatcaa gccaatcctg     1140

gagaagatgg acggcactga ggaactgctc gtgaagctga accgggagga cttgctgaga     1200

aaacagagaa ccttcgacaa tggaagcatc ccgcaccaga tccatctcgg ggaactgcat     1260

gctattctga gaaggcaaga ggatttctac ccctttctga aggataacag agaaaagatc     1320

gaaaagattt tgaccttccg catcccatac tacgtggggc ctctagccag gggcaacagc     1380

cggtttgcat ggatgacccg caagtcggag gaaacgatca ctccgtggaa cttcgaggaa     1440

gtggtggaca aaggagcgtc agctcagtcc tttatcgaac gcatgacgaa cttcgataag     1500

aatctcccaa acgaaaaggt gcttccaaag cattcgctgc tctacgaata cttcaccgtg     1560

tacaacgaac tcactaaggt gaagtacgtc actgaaggga tgcgcaagcc ggcatttctg     1620

tcgggagagc aaaagaaagc aatcgtggac ctgctgttca agaccaacag aaaggtgact     1680

gtcaagcagt tgaaagaaga ttatttcaaa aaaatcgaat gttttgatag cgtggaaatc     1740

tccggtgtgg aggacagatt taatgcttca ctgggcactt accacgacct gctcaaaatc     1800

atcaaagaca aagatttcct cgataacgag gaaaacgagg acatcctgga ggacattgtg     1860

ctgacgctga ctctgttcga ggatcgcgag atgatcgagg aacgcctgaa gacttatgcc     1920

catctcttcg acgacaaggt gatgaaacag ctcaaacgcc ggagatacac cggatgggga     1980

cggctgtcga gaaaactgat taacggaatc agggataaac aatcgggcaa aactatcctg     2040

gactttctaa agtcagatgg gttcgcaaac cggaatttca tgcagctcat ccacgacgac     2100

tccttgactt tcaaggagga tattcagaaa gcccaagtct ccggacaggg agactccctg     2160

catgagcaca tcgcgaatct ggcaggatcg cccgcaatta agaagggcat tctccagact     2220

gtgaaggtcg tggacgaact ggtcaaagtc atgggacgcc ataagccaga gaacatcgtg     2280

atcgagatgg cgcgggaaaa ccagaccact cagaaggggc agaagaacag cagagaaaga     2340

atgaaacgca tcgaagaagg catcaaggaa ctcggaagcc aaatcctcaa ggaacatccg     2400

gtcgagaata ctcagctaca gaatgagaag ctctacctgt actacctgca aaatggtcgg     2460

gatatgtacg tcgatcaaga actagacatc aacaggctgt cggattacga tgtggacgcc     2520

atcgtgcccc aatcattcct gaaggacgat tcgattgata ataaggtgct cactagatca     2580

gacaaaaaca gaggaaaatc ggacaacgtg ccgtcagaag aggtggtgaa gaagatgaag     2640

aattactggc gccaactgct gaacgcaaag ctgattaccc agagaaaatt cgacaatttg     2700

accaaggcag agcgcggagg tctgtcagag cttgacaagg cggggtttat caagaggcaa     2760

ctggtcgaaa cccgccagat cactaaacac gtggcgcaga tcctcgactc cagaatgaac     2820

actaagtacg acgaaaatga taaattgatc cgggaagtca aggtgattac cctgaaatca     2880

aaactggtgt cagattttcg caaggacttc caattctaca aggtcaggga gatcaacaat     2940

taccaccatg cccacgatgc ctacctgaac gcggtggtgg gcactgcgct catcaagaag     3000

tacccaaaac tggaatcgga gttcgtgtac ggagattaca aggtgtacga cgtgcgcaaa     3060

atgatcgcta agtcagagca ggaaatcgga aaagccaccg cgaaatactt cttctactcg     3120

aacattatga attttttcaa aactgagatt actcttgcga acggcgagat ccgcaaacgc     3180

cccttgatcg aaactaatgg ggaaaccggc gaaatcgtct gggataaggg cagggatttc     3240

gctaccgtca ggaaggtgct gtcaatgccg caagtgaata tcgtgaaaaa aaccgaagtc     3300

caaaccggag gtttcagcaa agagtccatc ctgcccaagc gcaactcgga taagctcatt     3360

gctaggaaga aagattggga ccccaagaaa tacggcgggt tcgactcgcc gaccgtggca     3420

tactccgtgc tggtggtggc caaggtcgaa aaaggaaaat caaagaagct gaaatccgtg     3480

aaggaattgc tgggaatcac tatcatggag cggtcctcct ttgaaaagaa tccaattgac     3540

tttctggaag caaagggcta caaggaggtg aaaaaggacc tgattatcaa acttccaaag     3600

tactcactct ttgagctgga aaacggtaga aagagaatgc tggcgagcgc tggagagctg     3660

cagaagggaa atgaactggc actgccgtcg aagtacgtga attttcttta tctggcatca     3720

cactacgaaa aactcaaagg ttcacctgaa gataatgagc aaaagcagct atttgtcgaa     3780

caacacaagc attacttgga cgaaatcatc gaacagattt cggaattttc aaagagagtg     3840

atcctggcgg atgccaatct ggacaaggtg ctctcggcgt acaacaagca tcgcgacaag     3900

ccgatccgcg agcaagcaga gaatatcatc cacctgttca ccctaacgaa cctgggagcg     3960

ccggcggcct tcaaatattt cgacaccact atcgaccgga aacggtacac ctcaaccaag     4020

gaagtgctcg acgcaaccct gatccatcag tccatcaccg gcctctatga aacccggatc     4080

gacctgtcac agctcggcgg tgactcgcgg gctgacccga aaaagaagag aaaggtctac     4140

gtggagaaaa agagagaaac ttcgatggat agccggctgc agaggattca tgcagaaatc     4200

aagaactcac tgaagattga taacctggat gtcaaccggt gcatcgaagc tctggacgaa     4260

ctggcctcgc ttcaggtgac tatgcagcaa gcccaaaagc acaccgaaat gattaccacc     4320

ctgaagaaga ttcggagatt taaggtgtcg caagtgatta tggaaaagtc aacttaa        4377


<210>  11
<211>  4374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector

<400>  11
atggataaga aatactcaat cggactggcc atcggcacta attcggtggg atgggcagtg       60

attaccgatg agtacaaggt cccgtcgaag aagtttaagg tgctgggaaa caccgataga      120

cactcgatca agaagaacct catcggcgct ctgctgtttg attccggcga gactgcggaa      180

gccacccggc tgaagcgcac tgcccgcaga agatacaccc ggcggaaaaa tagaatctgc      240

tacctccagg agattttctc gaacgaaatg gcaaaggtgg acgattcatt cttccatcgc      300

ctggaagaga gcttcctggt ggaagaggat aagaagcatg agcgccatcc tatcttcggg      360

aacattgtgg acgaagtggc ctatcacgag aaatacccga ctatctatca tctccgcaag      420

aagctggtgg actcaaccga taaggccgac ctgaggctga tctacctggc actggcacat      480

atgattaaat tccggggcca tttccttatc gagggggatc tgaatccgga taactccgat      540

gtcgataagc tgttcatcca gctggtccag acttacaatc agctgttcga ggaaaatccg      600

atcaatgcgt cgggcgtgga cgccaaggcc atcctctcgg cgaggctgtc aaaaagcagg      660

cgcctcgaaa acctgatcgc gcagctgccg ggggaaaaaa agaacggcct gtttgggaat      720

ctgatcgccc tctcactggg actaaccccg aatttcaagt cgaatttcga tctcgcagaa      780

gacgccaagc tgcaattgtc caaggatacc tacgacgatg atctggataa tctactggct      840

cagatcggag atcagtacgc ggacctgttc ttggccgcta agaacctctc ggacgccatt      900

ctgctgagcg acatcctgcg cgtcaatact gagatcacca aagcgccact gagcgcgtcg      960

atgattaaga gatacgacga acatcatcag gatctgactc tgctgaaggc cctcgtccgc     1020

cagcagctcc cggaaaagta caaggagatt ttctttgacc agtcgaagaa tggctacgca     1080

ggctatatcg acggaggcgc cagccaagaa gagttttaca agttcatcaa gccaatcctg     1140

gagaagatgg acggcactga ggaactgctc gtgaagctga accgggagga cttgctgaga     1200

aaacagagaa ccttcgacaa tggaagcatc ccgcaccaga tccatctcgg ggaactgcat     1260

gctattctga gaaggcaaga ggatttctac ccctttctga aggataacag agaaaagatc     1320

gaaaagattt tgaccttccg catcccatac tacgtggggc ctctagccag gggcaacagc     1380

cggtttgcat ggatgacccg caagtcggag gaaacgatca ctccgtggaa cttcgaggaa     1440

gtggtggaca aaggagcgtc agctcagtcc tttatcgaac gcatgacgaa cttcgataag     1500

aatctcccaa acgaaaaggt gcttccaaag cattcgctgc tctacgaata cttcaccgtg     1560

tacaacgaac tcactaaggt gaagtacgtc actgaaggga tgcgcaagcc ggcatttctg     1620

tcgggagagc aaaagaaagc aatcgtggac ctgctgttca agaccaacag aaaggtgact     1680

gtcaagcagt tgaaagaaga ttatttcaaa aaaatcgaat gttttgatag cgtggaaatc     1740

tccggtgtgg aggacagatt taatgcttca ctgggcactt accacgacct gctcaaaatc     1800

atcaaagaca aagatttcct cgataacgag gaaaacgagg acatcctgga ggacattgtg     1860

ctgacgctga ctctgttcga ggatcgcgag atgatcgagg aacgcctgaa gacttatgcc     1920

catctcttcg acgacaaggt gatgaaacag ctcaaacgcc ggagatacac cggatgggga     1980

cggctgtcga gaaaactgat taacggaatc agggataaac aatcgggcaa aactatcctg     2040

gactttctaa agtcagatgg gttcgcaaac cggaatttca tgcagctcat ccacgacgac     2100

tccttgactt tcaaggagga tattcagaaa gcccaagtct ccggacaggg agactccctg     2160

catgagcaca tcgcgaatct ggcaggatcg cccgcaatta agaagggcat tctccagact     2220

gtgaaggtcg tggacgaact ggtcaaagtc atgggacgcc ataagccaga gaacatcgtg     2280

atcgagatgg cgcgggaaaa ccagaccact cagaaggggc agaagaacag cagagaaaga     2340

atgaaacgca tcgaagaagg catcaaggaa ctcggaagcc aaatcctcaa ggaacatccg     2400

gtcgagaata ctcagctaca gaatgagaag ctctacctgt actacctgca aaatggtcgg     2460

gatatgtacg tcgatcaaga actagacatc aacaggctgt cggattacga tgtggacgcc     2520

atcgtgcccc aatcattcct gaaggacgat tcgattgata ataaggtgct cactagatca     2580

gacaaaaaca gaggaaaatc ggacaacgtg ccgtcagaag aggtggtgaa gaagatgaag     2640

aattactggc gccaactgct gaacgcaaag ctgattaccc agagaaaatt cgacaatttg     2700

accaaggcag agcgcggagg tctgtcagag cttgacaagg cggggtttat caagaggcaa     2760

ctggtcgaaa cccgccagat cactaaacac gtggcgcaga tcctcgactc cagaatgaac     2820

actaagtacg acgaaaatga taaattgatc cgggaagtca aggtgattac cctgaaatca     2880

aaactggtgt cagattttcg caaggacttc caattctaca aggtcaggga gatcaacaat     2940

taccaccatg cccacgatgc ctacctgaac gcggtggtgg gcactgcgct catcaagaag     3000

tacccaaaac tggaatcgga gttcgtgtac ggagattaca aggtgtacga cgtgcgcaaa     3060

atgatcgcta agtcagagca ggaaatcgga aaagccaccg cgaaatactt cttctactcg     3120

aacattatga attttttcaa aactgagatt actcttgcga acggcgagat ccgcaaacgc     3180

cccttgatcg aaactaatgg ggaaaccggc gaaatcgtct gggataaggg cagggatttc     3240

gctaccgtca ggaaggtgct gtcaatgccg caagtgaata tcgtgaaaaa aaccgaagtc     3300

caaaccggag gtttcagcaa agagtccatc ctgcccaagc gcaactcgga taagctcatt     3360

gctaggaaga aagattggga ccccaagaaa tacggcgggt tcgactcgcc gaccgtggca     3420

tactccgtgc tggtggtggc caaggtcgaa aaaggaaaat caaagaagct gaaatccgtg     3480

aaggaattgc tgggaatcac tatcatggag cggtcctcct ttgaaaagaa tccaattgac     3540

tttctggaag caaagggcta caaggaggtg aaaaaggacc tgattatcaa acttccaaag     3600

tactcactct ttgagctgga aaacggtaga aagagaatgc tggcgagcgc tggagagctg     3660

cagaagggaa atgaactggc actgccgtcg aagtacgtga attttcttta tctggcatca     3720

cactacgaaa aactcaaagg ttcacctgaa gataatgagc aaaagcagct atttgtcgaa     3780

caacacaagc attacttgga cgaaatcatc gaacagattt cggaattttc aaagagagtg     3840

atcctggcgg atgccaatct ggacaaggtg ctctcggcgt acaacaagca tcgcgacaag     3900

ccgatccgcg agcaagcaga gaatatcatc cacctgttca ccctaacgaa cctgggagcg     3960

ccggcggcct tcaaatattt cgacaccact atcgaccgga aacggtacac ctcaaccaag     4020

gaagtgctcg acgcaaccct gatccatcag tccatcaccg gcctctatga aacccggatc     4080

gacctgtcac agctcggcgg tgacgtggag aaaaagagag aaacttcgat ggatagccgg     4140

ctgcagagga ttcatgcaga aatcaagaac tcactgaaga ttgataacct ggatgtcaac     4200

cggtgcatcg aagctctgga cgaactggcc tcgcttcagg tgactatgca gcaagcccaa     4260

aagcacaccg aaatgattac caccctgaag aagattcgga gatttaaggt gtcgcaagtg     4320

attatggaaa agtcaacttc gcgggctgac ccgaaaaaga agagaaaggt ctag           4374


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  12
gtcccctcca ccccacagtg ggg                                               23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA

<400>  13
ggggccacta gggacaggat tgg                                               23


<210>  14
<211>  4653
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector

<400>  14
gcgatcgcgg ctcccgacat cttggaccat tagctccaca ggtatcttct tccctctagt       60

ggtcataaca gcagcttcag ctacctctca attcaaaaaa cccctcaaga cccgtttaga      120

ggccccaagg ggttatgcta tcaatcgttg cgttacacac acaaaaaacc aacacacatc      180

catcttcgat ggatagcgat tttattatct aactgctgat cgagtgtagc cagatctagt      240

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta      300

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga      360

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      420

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta      480

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg      540

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg ctgatgcggt      600

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      660

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      720

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      780

atataagcag agctggttta gtgaaccgtc agatcagatc tttgtcgatc ctaccatcca      840

ctcgacacac ccgccagcgg ccgctgccaa gcttccgagc tctcgaattc aaaggaggta      900

cccaccatgg ggtaccgcga tatctacctc gaggtttcta gaagttgtct cctcctgcac      960

tgactgactg atacaatcga tttctggatc cgcaggcctc tgctagcttg actgactgag     1020

atacagcgta ccttcagctc acagacatga taagatacat tgatgagttt ggacaaacca     1080

caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat     1140

ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt     1200

ttcaggttca gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg     1260

gtattggccc atctctatcg gtatcgtagc ataacccctt ggggcctcta aacgggtctt     1320

gaggggtttt ttgtgcccct cgggccggat tgctatctac cggcattggc gcagaaaaaa     1380

atgcctgatg cgacgctgcg cgtcttatac tcccacatat gccagattca gcaacggata     1440

cggcttcccc aacttgccca cttccatacg tgtcctcctt accagaaatt tatccttaag     1500

gtcgtcagct atcctgcagg cgatctctcg atttcgatca agacattcct ttaatggtct     1560

tttctggaca ccactagggg tcagaagtag ttcatcaaac tttcttccct ccctaatctc     1620

attggttacc ttgggctatc gaaacttaat taaccaaggt cgggcaggaa gagggcctat     1680

ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag ataattagaa     1740

ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat     1800

ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg     1860

taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg     1920

tcccctccac cccacagtgg ttttagagct agaaatagca agttaaaata aggctagtcc     1980

gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt ttcaagaccc agctttcttg     2040

tacaaagttg gcattaatta accagtcaag tcagctactt ggcgagatcg acttgtctgg     2100

gtttcgacta cgctcagaat tgcgtcagtc aagttcgatc tggtccttgc tattgcaccc     2160

gttctccgat tacgagtttc atttaaatca tgtgagcaaa aggccagcaa aaggccagga     2220

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     2280

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     2340

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     2400

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     2460

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     2520

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     2580

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     2640

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg     2700

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     2760

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     2820

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     2880

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     2940

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     3000

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt     3060

catccatagt tgcatttaaa tttccgaact ctccaaggcc ctcgtcggaa aatcttcaaa     3120

cctttcgtcc gatccatctt gcaggctacc tctcgaacga actatcgcaa gtctcttggc     3180

cggccttgcg ccttggctat tgcttggcag cgcctatcgc caggtattac tccaatcccg     3240

aatatccgag atcgggatca cccgagagaa gttcaaccta catcctcaat cccgatctat     3300

ccgagatccg aggaatatcg aaatcggggc gcgcctggtg taccgagaac gatcctctca     3360

gtgcgagtct cgacgatcca tatcgttgct tggcagtcag ccagtcggaa tccagcttgg     3420

gacccaggaa gtccaatcgt cagatattgt actcaagcct ggtcacggca gcgtaccgat     3480

ctgtttaaac ctagatattg atagtctgat cggtcaacgt ataatcgagt cctagctttt     3540

gcaaacatct atcaagagac aggatcagca ggaggctttc gcatgattga acaagatgga     3600

ttgcacgcag gttctccggc ggcttgggtg gagaggctat tcggctatga ctgggcacaa     3660

cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgtccggtt     3720

ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaagacga ggcagcgcgg     3780

ctatcgtggc tggcgacgac gggcgttcct tgcgcggctg tgctcgacgt tgtcactgaa     3840

gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac     3900

cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt     3960

gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact     4020

cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg     4080

ccagccgaac tgttcgccag gctcaaggcg tctatgcccg acggcgagga tctcgtcgtg     4140

acccacggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc     4200

atcgactgtg gccgtctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt     4260

gatattgctg aagagcttgg cggcgaatgg gctgaccgct tccttgtgct ttacggtatc     4320

gccgcgcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgaccg     4380

attctaggtg cattggcgca gaaaaaaatg cctgatgcga cgctgcgcgt cttatactcc     4440

cacatatgcc agattcagca acggatacgg cttccccaac ttgcccactt ccatacgtgt     4500

cctccttacc agaaatttat ccttaaggtc gtttaaactc gactctggct ctatcgaatc     4560

tccgtcgttt cgagcttacg cgaacagccg tggcgctcat ttgctcgtcg ggcatcgaat     4620

ctcgtcagct atcgtcagct tacctttttg gca                                  4653


<210>  15
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression cassette

<400>  15
ccaaggtcgg gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attagaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccgtcc cctccacccc acagtggttt tagagctaga      300

aatagcaagt taaaataagg ctagtccgtt atcaacttga aaaagtggca ccgagtcggt      360

gctttttttc aagacccagc tttcttgtac aaagttggca                            400


<210>  16
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression cassette

<400>  16
ccaaggtcgg gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat       60

acaaggctgt tagagagata attagaatta atttgactgt aaacacaaag atattagtac      120

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt      180

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat      240

atatcttgtg gaaaggacga aacaccgggg ccactaggga caggatgttt tagagctaga      300

aatagcaagt taaaataagg ctagtccgtt atcaacttga aaaagtggca ccgagtcggt      360

gctttttttc aagacccagc tttcttgtac aaagttggca                            400


<210>  17
<211>  6951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression vector

<400>  17
gcgatcgcag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt       60

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac      120

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg      180

ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag      240

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat      300

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat      360

ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt      420

tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga      480

ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg      540

gtgggaggtc tatataagca gagctcgttt agtgaaccgg ggtctctctg gttagaccag      600

atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc      660

ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga      720

tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg aacagggacc      780

tgaaagcgaa agggaaacca gagctctctc gacgcaggac tcggcttgct gaagcgcgca      840

cggcaagagg cgaggggcgg cgactggtga gtacgccaaa aattttgact agcggaggct      900

agaaggagag agatgggtgc gagagcgtca gtattaagcg ggggagaatt agatcgcgat      960

gggaaaaaat tcggttaagg ccagggggaa agaaaaaata taaattaaaa catatagtat     1020

gggcaagcag ggagctagaa cgattcgcag ttaatcctgg cctgttagaa acatcagaag     1080

gctgtagaca aatactggga cagctacaac catcccttca gacaggatca gaagaactta     1140

gatcattata taatacagta gcaaccctct attgtgtgca tcaaaggata gagataaaag     1200

acaccaagga agctttagac aagatagagg aagagcaaaa caaaagtaag accaccgcac     1260

agcaagcggc cgctgatctt cagacctgga ggaggagata tgagggacaa ttggagaagt     1320

gaattatata aatataaagt agtaaaaatt gaaccattag gagtagcacc caccaaggca     1380

aagagaagag tggtgcagag agaaaaaaga gcagtgggaa taggagcttt gttccttggg     1440

ttcttgggag cagcaggaag cactatgggc gcagcctcaa tgacgctgac ggtacaggcc     1500

agacaattat tgtctggtat agtgcagcag cagaacaatt tgctgagggc tattgaggcg     1560

caacagcatc tgttgcaact cacagtctgg ggcatcaagc agctccaggc aagaatcctg     1620

gctgtggaaa gatacctaaa ggatcaacag ctcctgggga tttggggttg ctctggaaaa     1680

ctcatttgca ccactgctgt gccttggaat gctagttgga gtaataaatc tctggaacag     1740

atttggaatc acacgacctg gatggagtgg gacagagaaa ttaacaatta cacaagctta     1800

atacactcct taattgaaga atcgcaaaac cagcaagaaa agaatgaaca agaattattg     1860

gaattagata aatgggcaag tttgtggaat tggtttaaca taacaaattg gctgtggtat     1920

ataaaattat tcataatgat agtaggaggc ttggtaggtt taagaatagt ttttgctgta     1980

ctttctatag tgaatagagt taggcaggga tattcaccat tatcgtttca gacccacctc     2040

ccaaccccga ggggacccga caggcccgaa ggaatagaag aagaaggtgg agagagagac     2100

agagacagat ccattcgatt agtgaacgga tctcgacggt atcggttaac ttttaaaaga     2160

aaagggggga ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac     2220

atacaaacta aagaattaca aaaacaaatt acaaaaattc aaaattttgg ctcccgatcg     2280

ttgcgttaca cacacaatta ctgctgatcg agtgtagcct tcgaatgaaa gaccccacct     2340

gtaggtttgg caagctagct gcagtaacgc cattttgcaa ggcatggaaa aataccaaac     2400

caagaataga gaagttcaga tcaagggcgg gtacatgaaa atagctaacg ttgggccaaa     2460

caggatatct gcggtgagca gtttcggccc cggcccgggg ccaagaacag atggtcaccg     2520

cagtttcggc cccggcccga ggccaagaac agatggtccc cagatatggc ccaaccctca     2580

gcagtttctt aagacccatc agatgtttcc aggctccccc aaggacctga aatgaccctg     2640

cgccttattt gaattaacca atcagcctgc ttctcgcttc tgttcgcgcg cttctgcttc     2700

ccgagctcta taaaagagct cacaacccct cactcggcgc gccagtcctc cgattgactg     2760

agtcgccctt gtcgatccta ccatccactc gacacacccg ccagggccgc tgccaagctt     2820

ccgagctctc gaattcaaag gaggtaccca ccatgacagc tctgacagag ggagcgaaac     2880

tgttcgagaa ggagatcccg tacatcacag agttggaagg agatgtcgaa gggatgaaat     2940

tcatcatcaa gggagaagga acgggtgacg caacgaccgg aacgatcaag gccaaataca     3000

tttgtaccac gggcgatttg cctgtcccct gggcgacgct tgtaagcacg ctctcgtatg     3060

gtgtccagtg cttcgcgaaa tatccatcgc acattaagga ctttttcaag tcggccatgc     3120

cagaaggtta cacacaagaa cgaaccatct cctttgaggg ggacggagtg tataagacac     3180

gcgcgatggt aacgtacgag cgcgggtcca tctacaacag ggtaactctt actggggaga     3240

actttaagaa ggacgggcat atcttgcgga aaaacgtggc atttcaatgt ccgccctcga     3300

ttctgtatat tctcccggac acggtgaata atgggatcag agtggagttc aaccaggcat     3360

acgatattga gggtgtgact gaaaagctcg tcaccaaatg cagccagatg aatcgccccc     3420

ttgcgggatc agcagccgtc catatccccc ggtatcacca tattacctac cacacaaaac     3480

tctcaaaaga cagagatgag agaagggacc atatgtgcct ggtcgaagta gtgaaggcgg     3540

tggatcttga tacataccag tagaagttgt ctcctcctgc actgactgac tgatacaatc     3600

gatttctgga tccgcaggcc tctactagtt gactgactga gatacagcgt accttcagct     3660

catccttaag gtcgtcagct atcgatctct cgatttcgat caagaggggt cagaagtagt     3720

tcatcagcgg ccgcgtcgac aatcaacctc tggattacaa aatttgtgaa agattgactg     3780

gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt     3840

atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc     3900

tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt     3960

ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga     4020

ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct     4080

gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaagctga     4140

cgtcctttcc atggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct     4200

gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc     4260

tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg     4320

cctccccgcc tggaattcga gctcggtacc tttaagacca atgacttaca aggcagctgt     4380

agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg     4440

aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg     4500

ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt     4560

gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc     4620

cttttagtca gtgtggaaaa tctctagcag tcctggccaa cgtgagcacc gtgctgacct     4680

ccaaatatcg ttaagctgga gcctgggagc cggcctggcc ctccgccccc cccacccccg     4740

cagcccaccc ctggtctttg aataaagtct gagtgagtgg ccgacagtgc ccgtggagtt     4800

ctcgtgacct gaggtgcagg gccggcgcta gggacacgtc cgtgcacgtg ccgaggcccc     4860

ctgtgcagct gcaagggaca ggcctagccc tgcaggttaa ttaaatttaa atcatgtgag     4920

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     4980

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     5040

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     5100

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     5160

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     5220

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     5280

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     5340

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     5400

gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     5460

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg     5520

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     5580

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     5640

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct     5700

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta     5760

tctcagcgat ctgtctattt cgttcatcca tagttgcatt taaatggccg gcctggcgcg     5820

ccgtttaaac ctagatattg atagtctgat cggtcaacgt ataatcgagt cctagctttt     5880

gcaaacatct atcaagagac aggatcagca ggaggctttc gcatgagtat tcaacatttc     5940

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     6000

acgctggtga aagtaaaaga tgctgaagat cagttgggtg cgcgagtggg ttacatcgaa     6060

ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg ctttccaatg     6120

atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga cgccgggcaa     6180

gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta ttcaccagtc     6240

acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc tgccataacc     6300

atgagtgata acactgcggc caacttactt ctgacaacga ttggaggacc gaaggagcta     6360

accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg ggaaccggag     6420

ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc aatggcaaca     6480

accttgcgta aactattaac tggcgaacta cttactctag cttcccggca acagttgata     6540

gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct tccggctggc     6600

tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat cattgcagca     6660

ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg gagtcaggca     6720

actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat taagcattgg     6780

taaccgattc taggtgcatt ggcgcagaaa aaaatgcctg atgcgacgct gcgcgtctta     6840

tactcccaca tatgccagat tcagcaacgg atacggcttc cccaacttgc ccacttccat     6900

acgtgtcctc cttaccagaa atttatcctt aagatcccga atcgtttaaa c              6951


<210>  18
<211>  5157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  18
gcgatcgcgg ctcccgacat cttggaccat tagctccaca ggtatcttct tccctctagt       60

ggtcataaca gcagcttcag ctacctctca attcaaaaaa cccctcaaga cccgtttaga      120

ggccccaagg ggttatgcta tcaatcgttg cgttacacac acaaaaaacc aacacacatc      180

catcttcgat ggatagcgat tttattatct aactgctgat cgagtgtagc cagatctagt      240

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta      300

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga      360

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      420

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta      480

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg      540

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg ctgatgcggt      600

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      660

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      720

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      780

atataagcag agctggttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt      840

ttgacctcca tagaagacac cgggaccgat ccagcctccc ctcgaagctt acatgtggta      900

ccgagctcgg atcctgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      960

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata     1020

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1080

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1140

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1200

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1260

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttat     1320

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcatgttca     1380

tacctcttat cttcctccca cagctcctgg gcaacgtgct ggtctgtgtg ctggcccatc     1440

actttggcaa aggcggccgc tgccaagctt ccgagctctc gaattcaaag gaggtaccca     1500

ccatggccgg cagatcagga gactcggatg aagagttgat tcgcaccgtc cgccttatca     1560

agtttctata ccaatcgaac ccaccaccca acccggaggg cactcgccag gctcgcagaa     1620

acagacgcag acgctggaga gaaagacaaa ggcagatcca ctcaattagc gagcggattc     1680

tgtcaacgta cctaggccgg tcagctgatg ccgtgccctt gcaactgcca ccgctggaac     1740

ggttgaccct ggactgcaac gaggactgcg gaacctcggg cactcaagga gtgggctcgc     1800

cccagatcct ggtcgaatcg ccgacggtcc tggaaagcgg gaccaaggag tagaagttgt     1860

ctcctcctgc actgactgac tgatacaatc gatttctgga tccgcaggcc tctgctagct     1920

tgactgactg agatacagcg taccttcagc tcacagacat gataagatac attgatgagt     1980

ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg     2040

ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca     2100

ttcattttat gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc     2160

tctacaaatg tggtattggc ccatctctat cggtatcgta gcataacccc ttggggcctc     2220

taaacgggtc ttgaggggtt ttttgtgccc ctcgggccgg attgctatct accggcattg     2280

gcgcagaaaa aaatgcctga tgcgacgctg cgcgtcttat actcccacat atgccagatt     2340

cagcaacgga tacggcttcc ccaacttgcc cacttccata cgtgtcctcc ttaccagaaa     2400

tttatcctta aggtcgtcag ctatcctgca ggcgatctct cgatttcgat caagacattc     2460

ctttaatggt cttttctgga caccactagg ggtcagaagt agttcatcaa actttcttcc     2520

ctccctaatc tcattggtta ccttgggcta tcgaaactta attaaccagt caagtcagct     2580

acttggcgag atcgacttgt ctgggtttcg actacgctca gaattgcgtc agtcaagttc     2640

gatctggtcc ttgctattgc acccgttctc cgattacgag tttcatttaa atcatgtgag     2700

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     2760

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     2820

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     2880

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     2940

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     3000

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     3060

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     3120

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     3180

gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     3240

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg     3300

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     3360

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     3420

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct     3480

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta     3540

tctcagcgat ctgtctattt cgttcatcca tagttgcatt taaatttccg aactctccaa     3600

ggccctcgtc ggaaaatctt caaacctttc gtccgatcca tcttgcaggc tacctctcga     3660

acgaactatc gcaagtctct tggccggcct tgcgccttgg ctattgcttg gcagcgccta     3720

tcgccaggta ttactccaat cccgaatatc cgagatcggg atcacccgag agaagttcaa     3780

cctacatcct caatcccgat ctatccgaga tccgaggaat atcgaaatcg gggcgcgcct     3840

ggtgtaccga gaacgatcct ctcagtgcga gtctcgacga tccatatcgt tgcttggcag     3900

tcagccagtc ggaatccagc ttgggaccca ggaagtccaa tcgtcagata ttgtactcaa     3960

gcctggtcac ggcagcgtac cgatctgttt aaacctagat attgatagtc tgatcggtca     4020

acgtataatc gagtcctagc ttttgcaaac atctatcaag agacaggatc agcaggaggc     4080

tttcgcatga ttgaacaaga tggattgcac gcaggttctc cggcggcttg ggtggagagg     4140

ctattcggct atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg     4200

ctgtcagcgc aggggcgtcc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat     4260

gaactgcaag acgaggcagc gcggctatcg tggctggcga cgacgggcgt tccttgcgcg     4320

gctgtgctcg acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg     4380

gggcaggatc tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat     4440

gcaatgcggc ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa     4500

catcgcatcg agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg     4560

gacgaagagc atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgtctatg     4620

cccgacggcg aggatctcgt cgtgacccac ggcgatgcct gcttgccgaa tatcatggtg     4680

gaaaatggcc gcttttctgg attcatcgac tgtggccgtc tgggtgtggc ggaccgctat     4740

caggacatag cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac     4800

cgcttccttg tgctttacgg tatcgccgcg cccgattcgc agcgcatcgc cttctatcgc     4860

cttcttgacg agttcttctg accgattcta ggtgcattgg cgcagaaaaa aatgcctgat     4920

gcgacgctgc gcgtcttata ctcccacata tgccagattc agcaacggat acggcttccc     4980

caacttgccc acttccatac gtgtcctcct taccagaaat ttatccttaa ggtcgtttaa     5040

actcgactct ggctctatcg aatctccgtc gtttcgagct tacgcgaaca gccgtggcgc     5100

tcatttgctc gtcgggcatc gaatctcgtc agctatcgtc agcttacctt tttggca        5157


<210>  19
<211>  9130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  19
gcgatcgcgg ctcccgacat cttggaccat tagctccaca ggtatcttct tccctctagt       60

ggtcataaca gcagcttcag ctacctctca attcaaaaaa cccctcaaga cccgtttaga      120

ggccccaagg ggttatgcta tcaatcgttg cgttacacac acaaaaaacc aacacacatc      180

catcttcgat ggatagcgat tttattatct aactgctgat cgagtgtagc cagatctagt      240

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta      300

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga      360

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      420

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta      480

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg      540

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg ctgatgcggt      600

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      660

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      720

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      780

atataagcag agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt      840

ttgacctcca tagaagacac cgggaccgat ccagcctccc ctcgaagctt acatgtggta      900

ccgagctcgg atcctgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      960

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata     1020

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1080

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1140

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1200

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1260

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttat     1320

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcatgttca     1380

tacctcttat cttcctccca cagctcctgg gcaacgtgct ggtctgtgtg ctggcccatc     1440

actttggcaa aggcggccgc tgccaagctt ccgagctctc gaattcaaag gaggtacccg     1500

agatgggcgc tcgcgcctca gtactgtcag ggggtgaact agacagatgg gaaaaaataa     1560

ggctgaggcc aggcggcaag aagaaatata agctgaagca tattgtgtgg gcctctaggg     1620

aacttgagcg atttgctgtg aatccggggt tgcttgaaac aagcgagggg tgccgccaaa     1680

tcctcggaca gctgcagcca tcactgcaga caggtagtga agagctgcgg agcctgtata     1740

ataccgttgc caccctttat tgcgtgcacc aacggatcga gattaaggac acaaaggagg     1800

ccctagacaa gatcgaagaa gaacagaaca agagcaagaa aaaagcccag caggccgcag     1860

ccgatacagg ccactcaaac caggtttccc agaactaccc tatcgtccaa aatatacagg     1920

gtcagatggt gcatcaagcc atcagcccga gaacattgaa tgcatgggtg aaagtggtcg     1980

aggagaaggc tttttcacca gaggtgatcc ctatgtttag cgccctgagc gagggtgcca     2040

cgccccagga tttgaataca atgttgaaca ccgtcggggg ccaccaggcg gcaatgcaaa     2100

tgctgaaaga gactattaat gaagaagcag ctgagtggga cagagtgcat cccgtgcacg     2160

ccggtccaat tgctcctgga cagatgcgtg aaccccgtgg atctgacatc gccggtacta     2220

cttctaccct ccaggagcaa atcggatgga tgaccaacaa tccccccatt ccggtggggg     2280

aaatatataa gcggtggatt attttggggc tgaataagat cgttaggatg tactccccta     2340

catccatcct cgatattcga cagggtccca aagagccatt cagggattat gtcgatcggt     2400

tttataagac attgcgtgct gaacaggctt cccaggaagt caagaattgg atgaccgaga     2460

cactgttggt gcagaacgct aatcctgatt gtaagaccat tctaaaagct ctgggtcccg     2520

cagctactct ggaagagatg atgaccgcgt gccaaggagt cggggggcct ggccataagg     2580

ccagagtact tgccgaggcc atgagtcagg tgacaaactc tgcaacgata atgatgcaga     2640

ggggcaactt tcgcaatcaa cgcaaaattg tcaagtgctt caactgtggc aaagaagggc     2700

acacagcccg caactgcagg gccccaagga aaaagggctg ttggaaatgt ggaaaggaag     2760

gacaccaaat gaaagattgt actgagagac aggctaattt tttagggaag atctggcctt     2820

cccacaaggg aaggccaggg aattttcttc agagcagacc agagccaaca gccccaccag     2880

aagagagctt caggtttggg gaagagacaa caactccctc tcagaagcag gagccgatag     2940

acaaggaact gtatccttta gcttccctca gatcactctt tggcagcgac ccctcgtcac     3000

aataaagata ggggggcagc tcaaggaggc tctcctggac accggagcag acgacaccgt     3060

gctggaggag atgtcattac caggtaggtg gaaaccgaaa atgattgggg ggatcggcgg     3120

attcatcaag gtcaggcagt acgaccaaat actaattgag atttgtgggc acaaagctat     3180

aggaacggtg ctcgtgggac ccacgcccgt gaacatcatc ggcaggaacc tgctgacaca     3240

gatcggctgt acgctcaact tccccataag tcctatcgaa accgtccccg taaagttaaa     3300

gccaggcatg gatggaccta aagtgaagca gtggcctcta acagaagaga agataaaggc     3360

ccttgtggag atatgtactg aaatggaaaa agagggaaag ataagtaaaa ttggccccga     3420

gaatccctac aacacccctg tctttgccat caagaagaaa gattccacca aatggcgcaa     3480

gctagtggac ttccgggagt taaataagcg aacacaggac ttctgggaag tgcagttggg     3540

gattccgcac cctgcgggcc tgaaaaagaa aaagagtgtg acagtcttgg atgtaggcga     3600

cgcctacttt agcgttccgc ttgacgagga tttcagaaag tacactgcat ttacaatccc     3660

atcaatcaat aacgagactc caggcatccg ctaccaatat aatgtgctgc cgcagggttg     3720

gaagggctct cctgccatat tccagtcgtc catgaccaag atactggagc ctttcaggaa     3780

acagaaccct gacattgtaa tttaccagta catggatgac ctttacgtag gatcagacct     3840

ggaaattggc cagcatcgga caaaaatcga ggagctgcgc cagcatctgc tgagatgggg     3900

cctcactaca cccgacaaga agcaccaaaa ggagcctcct tttctatgga tgggttatga     3960

acttcaccct gataagtgga ccgtgcaacc aatcgttcta ccagaaaagg acagttggac     4020

tgtcaacgac attcagaagc tggtgggcaa gctgaactgg gccagccaga tttatccggg     4080

gataaaagta agacaacttt gtaaactgtt gcgcggcact aaggcgttga cagaggtgat     4140

cccactcaca gaggaagccg aactagaact cgccgaaaac cgggagattt taaaggagcc     4200

agtgcacgga gtatattacg acccgagcaa ggatctaatc gccgaaattc agaaacaagg     4260

ccaagggcag tggacctatc aaatttatca ggaacctttc aagaacctga agacgggaaa     4320

gtacgccaga atgcgcgggg cacatacgaa tgacgtgaag caactcaccg aggctgtgca     4380

aaagatcaca acagagagta ttgtgatttg gggaaagacg cctaaattca agctgcccat     4440

ccagaaagaa acttgggaaa cgtggtggac agagtattgg caggcgacct ggattcccga     4500

gtgggagttc gtcaatactc ccccactcgt gaaactgtgg tatcagttag agaaggagcc     4560

cattgtcgga gccgaaacct tctacgtcga tggcgcagcc aatcgcgaga ctaaacttgg     4620

aaaggccggc tacgtgacta acagaggccg gcagaaagtg gtgacattga cggacacaac     4680

aaatcagaaa actgagctgc aagccatcta tcttgccctg caagattctg ggctagaagt     4740

gaacattgtg accgatagcc agtacgctct cgggatcatc caagcgcaac ccgatcagag     4800

tgaaagcgag ctggtcaacc aaatcataga gcagctgatt aagaaggaaa aggtttacct     4860

tgcctgggtt cccgctcata aagggattgg agggaacgag caggtcgata agctagttag     4920

cgctggcatt cggaaggtcc tcttcttaga cggaattgac aaggctcagg acgaacatga     4980

gaaataccac tcaaactgga gagctatggc ctctgacttc aacctacccc cagtcgtcgc     5040

caaagagatc gtggcatcct gtgacaagtg tcagctgaag ggtgaagcta tgcatggcca     5100

ggtggattgc agtcctggaa tttggcaatt ggattgtaca cacctggaag ggaaggtcat     5160

cttggttgca gtgcacgtgg cttcgggcta cattgaagcc gaagtcatac cggctgagac     5220

tggccaggaa acggcctatt ttttattgaa actggccggt cgctggccag tgaaaaccat     5280

ccataccgat aacggttcta attttacgag tgcaaccgtg aaagcggcgt gttggtgggc     5340

cggtatcaaa caagagttcg ggattccata taacccacaa tcccagggcg tcgtggagtc     5400

aatgaataaa gaactgaaga agatcatcgg ccaggtcaga gatcaagcag aacatctgaa     5460

aacagcagtt cagatggccg tgtttattca caacttcaag aggaaaggag ggattggcgg     5520

ctattcggcg ggggaaagaa tcgtcgatat tattgccacg gacatacaga ccaaggaact     5580

ccagaaacaa atcaccaaaa tccagaactt ccgcgtgtat taccgggaca gccggaatcc     5640

gctgtggaag ggacctgcta aattgctgtg gaaaggcgag ggcgctgtag tgattcagga     5700

caactcagac ataaaggttg ttccgcgtcg gaaagcgaag attatccggg actacgggaa     5760

gcaaatggct ggggatgatt gtgtagcttc tcggcaagac gaagattagt agtaggctag     5820

aactagaagt tgtctcctcc tgcactgact gactgataca atcgatttct ggatccgcag     5880

gcctctgcta gcttgactga ctgagataca gcgtaccttc agctcacaga catgataaga     5940

tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt     6000

gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac     6060

aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa     6120

agcaagtaaa acctctacaa atgtggtatt ggcccatctc tatcggtatc gtagcataac     6180

cccttggggc ctctaaacgg gtcttgaggg gttttttgtg cccctcgggc cggattgcta     6240

tctaccggca ttggcgcaga aaaaaatgcc tgatgcgacg ctgcgcgtct tatactccca     6300

catatgccag attcagcaac ggatacggct tccccaactt gcccacttcc atacgtgtcc     6360

tccttaccag aaatttatcc ttaaggtcgt cagctatcct gcaggcgatc tctcgatttc     6420

gatcaagaca ttcctttaat ggtcttttct ggacaccact aggggtcaga agtagttcat     6480

caaactttct tccctcccta atctcattgg ttaccttggg ctatcgaaac ttaattaacc     6540

agtcaagtca gctacttggc gagatcgact tgtctgggtt tcgactacgc tcagaattgc     6600

gtcagtcaag ttcgatctgg tccttgctat tgcacccgtt ctccgattac gagtttcatt     6660

taaatcatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     6720

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     6780

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     6840

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     6900

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     6960

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     7020

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     7080

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     7140

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     7200

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     7260

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     7320

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     7380

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt     7440

tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc     7500

agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc atttaaattt     7560

ccgaactctc caaggccctc gtcggaaaat cttcaaacct ttcgtccgat ccatcttgca     7620

ggctacctct cgaacgaact atcgcaagtc tcttggccgg ccttgcgcct tggctattgc     7680

ttggcagcgc ctatcgccag gtattactcc aatcccgaat atccgagatc gggatcaccc     7740

gagagaagtt caacctacat cctcaatccc gatctatccg agatccgagg aatatcgaaa     7800

tcggggcgcg cctggtgtac cgagaacgat cctctcagtg cgagtctcga cgatccatat     7860

cgttgcttgg cagtcagcca gtcggaatcc agcttgggac ccaggaagtc caatcgtcag     7920

atattgtact caagcctggt cacggcagcg taccgatctg tttaaaccta gatattgata     7980

gtctgatcgg tcaacgtata atcgagtcct agcttttgca aacatctatc aagagacagg     8040

atcagcagga ggctttcgca tgattgaaca agatggattg cacgcaggtt ctccggcggc     8100

ttgggtggag aggctattcg gctatgactg ggcacaacag acaatcggct gctctgatgc     8160

cgccgtgttc cggctgtcag cgcaggggcg tccggttctt tttgtcaaga ccgacctgtc     8220

cggtgccctg aatgaactgc aagacgaggc agcgcggcta tcgtggctgg cgacgacggg     8280

cgttccttgc gcggctgtgc tcgacgttgt cactgaagcg ggaagggact ggctgctatt     8340

gggcgaagtg ccggggcagg atctcctgtc atctcacctt gctcctgccg agaaagtatc     8400

catcatggct gatgcaatgc ggcggctgca tacgcttgat ccggctacct gcccattcga     8460

ccaccaagcg aaacatcgca tcgagcgagc acgtactcgg atggaagccg gtcttgtcga     8520

tcaggatgat ctggacgaag agcatcaggg gctcgcgcca gccgaactgt tcgccaggct     8580

caaggcgtct atgcccgacg gcgaggatct cgtcgtgacc cacggcgatg cctgcttgcc     8640

gaatatcatg gtggaaaatg gccgcttttc tggattcatc gactgtggcc gtctgggtgt     8700

ggcggaccgc tatcaggaca tagcgttggc tacccgtgat attgctgaag agcttggcgg     8760

cgaatgggct gaccgcttcc ttgtgcttta cggtatcgcc gcgcccgatt cgcagcgcat     8820

cgccttctat cgccttcttg acgagttctt ctgaccgatt ctaggtgcat tggcgcagaa     8880

aaaaatgcct gatgcgacgc tgcgcgtctt atactcccac atatgccaga ttcagcaacg     8940

gatacggctt ccccaacttg cccacttcca tacgtgtcct ccttaccaga aatttatcct     9000

taaggtcgtt taaactcgac tctggctcta tcgaatctcc gtcgtttcga gcttacgcga     9060

acagccgtgg cgctcatttg ctcgtcgggc atcgaatctc gtcagctatc gtcagcttac     9120

ctttttggca                                                            9130


<210>  20
<211>  6342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  20
gcgatcgcgg ctcccgacat cttggaccat tagctccaca ggtatcttct tccctctagt       60

ggtcataaca gcagcttcag ctacctctca attcaaaaaa cccctcaaga cccgtttaga      120

ggccccaagg ggttatgcta tcaatcgttg cgttacacac acaaaaaacc aacacacatc      180

catcttcgat ggatagcgat tttattatct aactgctgat cgagtgtagc cagatctagt      240

aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta      300

cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga      360

cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt      420

tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta      480

ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg      540

actttcctac ttggcagtac atctacgtat tagtcatcgc tattaccatg ctgatgcggt      600

tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc      660

accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat      720

gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct      780

atataagcag agctggttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt      840

ttgacctcca tagaagacac cgggaccgat ccagcctccc ctcgaagctt acatgtggta      900

ccgagctcgg atcctgagaa cttcagggtg agtctatggg acccttgatg ttttctttcc      960

ccttcttttc tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata     1020

ttgaccaaat cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata     1080

tacttttttg tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa     1140

tgatacaatg tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg     1200

ttaaggcaat agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt     1260

aagaggtttc atattgctaa tagcagctac aatccagcta ccattctgct tttattttat     1320

ggttgggata aggctggatt attctgagtc caagctaggc ccttttgcta atcatgttca     1380

tacctcttat cttcctccca cagctcctgg gcaacgtgct ggtctgtgtg ctggcccatc     1440

actttggcaa aggcggccgc tgccaagctt ccgagctctc gaattcaaag gaggtaccca     1500

ccatgaagtg ccttttgtac ttagcctttt tattcattgg ggtgaattgc aagttcacca     1560

tagtttttcc acacaaccaa aaaggaaact ggaaaaatgt tccttctaat taccattatt     1620

gcccgtcaag ctcagattta aattggcata atgacttaat aggcacagcc ttacaagtca     1680

aaatgcccaa gagtcacaag gctattcaag cagacggttg gatgtgtcat gcttccaaat     1740

gggtcactac ttgtgatttc cgctggtatg gaccgaagta tataacacat tccatccgat     1800

ccttcactcc atctgtagaa caatgcaagg aaagcattga acaaacgaaa caaggaactt     1860

ggctgaatcc aggcttccct cctcaaagtt gtggatatgc aactgtgacg gatgccgaag     1920

cagtgattgt ccaggtgact cctcaccatg tgctggttga tgaatacaca ggagaatggg     1980

ttgattcaca gttcatcaac ggaaaatgca gcaattacat atgccccact gtccataact     2040

ctacaacctg gcattctgac tataaggtca aagggctatg tgattctaac ctcatttcca     2100

tggacatcac cttcttctca gaggacggag agctatcatc cctgggaaag gagggcacag     2160

ggttcagaag taactacttt gcttatgaaa ctggaggcaa ggcctgcaaa atgcaatact     2220

gcaagcattg gggagtcaga ctcccatcag gtgtctggtt cgagatggct gataaggatc     2280

tctttgctgc agccagattc cctgaatgcc cagaagggtc aagtatctct gctccatctc     2340

agacctcagt ggatgtaagt ctaattcagg acgttgagag gatcttggat tattccctct     2400

gccaagaaac ctggagcaaa atcagagcgg gtcttccaat ctctccagtg gatctcagct     2460

atcttgctcc taaaaaccca ggaaccggtc ctgctttcac cataatcaat ggtaccctaa     2520

aatactttga gaccagatac atcagagtcg atattgctgc tccaatcctc tcaagaatgg     2580

tcggaatgat cagtggaact accacagaaa gggaactgtg ggatgactgg gcaccatatg     2640

aagacgtgga aattggaccc aatggagttc tgaggaccag ttcaggatat aagtttcctt     2700

tatacatgat tggacatggt atgttggact ccgatcttca tcttagctca aaggctcagg     2760

tgttcgaaca tcctcacatt caagacgctg cttcgcaact tcctgatgat gagagtttat     2820

tttttggtga tactgggcta tccaaaaatc caatcgagct tgtagaaggt tggttcagta     2880

gttggaaaag ctctattgcc tcttttttct ttatcatagg gttaatcatt ggactattct     2940

tggttctccg agttggtatc catctttgca ttaaattaaa gcacaccaag aaaagacaga     3000

tttatacaga catagagatg aaccgacttg gaaagtagaa gttgtctcct cctgcactga     3060

ctgactgata caatcgattt ctggatccgc aggcctctgc tagcttgact gactgagata     3120

cagcgtacct tcagctcaca gacatgataa gatacattga tgagtttgga caaaccacaa     3180

ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt gctttatttg     3240

taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat tttatgtttc     3300

aggttcaggg ggaggtgtgg gaggtttttt aaagcaagta aaacctctac aaatgtggta     3360

ttggcccatc tctatcggta tcgtagcata accccttggg gcctctaaac gggtcttgag     3420

gggttttttg tgcccctcgg gccggattgc tatctaccgg cattggcgca gaaaaaaatg     3480

cctgatgcga cgctgcgcgt cttatactcc cacatatgcc agattcagca acggatacgg     3540

cttccccaac ttgcccactt ccatacgtgt cctccttacc agaaatttat ccttaaggtc     3600

gtcagctatc ctgcaggcga tctctcgatt tcgatcaaga cattccttta atggtctttt     3660

ctggacacca ctaggggtca gaagtagttc atcaaacttt cttccctccc taatctcatt     3720

ggttaccttg ggctatcgaa acttaattaa ccagtcaagt cagctacttg gcgagatcga     3780

cttgtctggg tttcgactac gctcagaatt gcgtcagtca agttcgatct ggtccttgct     3840

attgcacccg ttctccgatt acgagtttca tttaaatcat gtgagcaaaa ggccagcaaa     3900

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     3960

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     4020

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     4080

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac     4140

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     4200

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     4260

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     4320

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagaa     4380

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     4440

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     4500

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     4560

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     4620

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     4680

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     4740

tatttcgttc atccatagtt gcatttaaat ttccgaactc tccaaggccc tcgtcggaaa     4800

atcttcaaac ctttcgtccg atccatcttg caggctacct ctcgaacgaa ctatcgcaag     4860

tctcttggcc ggccttgcgc cttggctatt gcttggcagc gcctatcgcc aggtattact     4920

ccaatcccga atatccgaga tcgggatcac ccgagagaag ttcaacctac atcctcaatc     4980

ccgatctatc cgagatccga ggaatatcga aatcggggcg cgcctggtgt accgagaacg     5040

atcctctcag tgcgagtctc gacgatccat atcgttgctt ggcagtcagc cagtcggaat     5100

ccagcttggg acccaggaag tccaatcgtc agatattgta ctcaagcctg gtcacggcag     5160

cgtaccgatc tgtttaaacc tagatattga tagtctgatc ggtcaacgta taatcgagtc     5220

ctagcttttg caaacatcta tcaagagaca ggatcagcag gaggctttcg catgattgaa     5280

caagatggat tgcacgcagg ttctccggcg gcttgggtgg agaggctatt cggctatgac     5340

tgggcacaac agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg     5400

cgtccggttc tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaagacgag     5460

gcagcgcggc tatcgtggct ggcgacgacg ggcgttcctt gcgcggctgt gctcgacgtt     5520

gtcactgaag cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg     5580

tcatctcacc ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg     5640

catacgcttg atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga     5700

gcacgtactc ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag     5760

gggctcgcgc cagccgaact gttcgccagg ctcaaggcgt ctatgcccga cggcgaggat     5820

ctcgtcgtga cccacggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt     5880

tctggattca tcgactgtgg ccgtctgggt gtggcggacc gctatcagga catagcgttg     5940

gctacccgtg atattgctga agagcttggc ggcgaatggg ctgaccgctt ccttgtgctt     6000

tacggtatcg ccgcgcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc     6060

ttctgaccga ttctaggtgc attggcgcag aaaaaaatgc ctgatgcgac gctgcgcgtc     6120

ttatactccc acatatgcca gattcagcaa cggatacggc ttccccaact tgcccacttc     6180

catacgtgtc ctccttacca gaaatttatc cttaaggtcg tttaaactcg actctggctc     6240

tatcgaatct ccgtcgtttc gagcttacgc gaacagccgt ggcgctcatt tgctcgtcgg     6300

gcatcgaatc tcgtcagcta tcgtcagctt acctttttgg ca                        6342


<210>  21
<211>  1121
<212>  PRT
<213>  Streptococcus thermophilus

<400>  21

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Ala Arg Arg Lys Lys His Arg Arg Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Asp Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Thr Thr Ser Ser Ser Asn Lys 
    450                 455                 460                 


Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr Glu Glu Ile Tyr Asn Pro 
465                 470                 475                 480 


Val Val Ala Lys Ser Val Arg Gln Ala Ile Lys Ile Val Asn Ala Ala 
                485                 490                 495     


Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile Val Ile Glu Met Ala Arg 
            500                 505                 510         


Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala Ile Gln Lys Ile Gln Lys 
        515                 520                 525             


Ala Asn Lys Asp Glu Lys Asp Ala Ala Met Leu Lys Ala Ala Asn Gln 
    530                 535                 540                 


Tyr Asn Gly Lys Ala Glu Leu Pro His Ser Val Phe His Gly His Lys 
545                 550                 555                 560 


Gln Leu Ala Thr Lys Ile Arg Leu Trp His Gln Gln Gly Glu Arg Cys 
                565                 570                 575     


Leu Tyr Thr Gly Lys Thr Ile Ser Ile His Asp Leu Ile Asn Asn Ser 
            580                 585                 590         


Asn Gln Phe Glu Val Asp His Ile Leu Pro Leu Ser Ile Thr Phe Asp 
        595                 600                 605             


Asp Ser Leu Ala Asn Lys Val Leu Val Tyr Ala Thr Ala Asn Gln Glu 
    610                 615                 620                 


Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu Asp Ser Met Asp Asp Ala 
625                 630                 635                 640 


Trp Ser Phe Arg Glu Leu Lys Ala Phe Val Arg Glu Ser Lys Thr Leu 
                645                 650                 655     


Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr Glu Glu Asp Ile Ser Lys 
            660                 665                 670         


Phe Asp Val Arg Lys Lys Phe Ile Glu Arg Asn Leu Val Asp Thr Arg 
        675                 680                 685             


Tyr Ala Ser Arg Val Val Leu Asn Ala Leu Gln Glu His Phe Arg Ala 
    690                 695                 700                 


His Lys Ile Asp Thr Lys Val Ser Val Val Arg Gly Gln Phe Thr Ser 
705                 710                 715                 720 


Gln Leu Arg Arg His Trp Gly Ile Glu Lys Thr Arg Asp Thr Tyr His 
                725                 730                 735     


His His Ala Val Asp Ala Leu Ile Ile Ala Ala Ser Ser Gln Leu Asn 
            740                 745                 750         


Leu Trp Lys Lys Gln Lys Asn Thr Leu Val Ser Tyr Ser Glu Asp Gln 
        755                 760                 765             


Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile Ser Asp Asp Glu Tyr Lys 
    770                 775                 780                 


Glu Ser Val Phe Lys Ala Pro Tyr Gln His Phe Val Asp Thr Leu Lys 
785                 790                 795                 800 


Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe Ser Tyr Gln Val Asp Ser 
                805                 810                 815     


Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr Ile Tyr Ala Thr Arg Gln 
            820                 825                 830         


Ala Lys Val Gly Lys Asp Lys Ala Asp Glu Thr Tyr Val Leu Gly Lys 
        835                 840                 845             


Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr Asp Ala Phe Met Lys Ile 
    850                 855                 860                 


Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met Tyr Arg His Asp Pro Gln 
865                 870                 875                 880 


Thr Phe Glu Lys Val Ile Glu Pro Ile Leu Glu Asn Tyr Pro Asn Lys 
                885                 890                 895     


Gln Ile Asn Asp Lys Gly Lys Glu Val Pro Cys Asn Pro Phe Leu Lys 
            900                 905                 910         


Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys Tyr Ser Lys Lys Gly Asn 
        915                 920                 925             


Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr Asp Ser Lys Leu Gly Asn 
    930                 935                 940                 


His Ile Asp Ile Thr Pro Lys Asp Ser Asn Asn Lys Val Val Leu Gln 
945                 950                 955                 960 


Ser Val Ser Pro Trp Arg Ala Asp Val Tyr Phe Asn Lys Thr Thr Gly 
                965                 970                 975     


Lys Tyr Glu Ile Leu Gly Leu Lys Tyr Ala Asp Leu Gln Phe Asp Lys 
            980                 985                 990         


Gly Thr Gly Thr Tyr Lys Ile Ser  Gln Glu Lys Tyr Asn  Asp Ile Lys 
        995                 1000                 1005             


Lys Lys  Glu Gly Val Asp Ser  Asp Ser Glu Phe Lys  Phe Thr Leu 
    1010                 1015                 1020             


Tyr Lys  Asn Asp Leu Leu Leu  Val Lys Asp Thr Glu  Thr Lys Glu 
    1025                 1030                 1035             


Gln Gln  Leu Phe Arg Phe Leu  Ser Arg Thr Met Pro  Lys Gln Lys 
    1040                 1045                 1050             


His Tyr  Val Glu Leu Lys Pro  Tyr Asp Lys Gln Lys  Phe Glu Gly 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ile Lys Val  Leu Gly Asn Val Ala  Asn Ser Gly 
    1070                 1075                 1080             


Gln Cys  Lys Lys Gly Leu Gly  Lys Ser Asn Ile Ser  Ile Tyr Lys 
    1085                 1090                 1095             


Val Arg  Thr Asp Val Leu Gly  Asn Gln His Ile Ile  Lys Asn Glu 
    1100                 1105                 1110             


Gly Asp  Lys Pro Lys Leu Asp  Phe 
    1115                 1120     


<210>  22
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  22

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  23
<211>  1082
<212>  PRT
<213>  Neisseria meningitidis

<400>  23

Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  24
<211>  1307
<212>  PRT
<213>  Unknown

<220>
<223>  Acidaminococcus sp. strain BV3L6

<400>  24

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


