               SEQUENCE LISTING

<110> IMBA - Institut für molekulare Biotechnologie GMBH
      Medizinische Universität Wien

<120> Cbl-family inhibitor comprising a Cbl-family TKB domain binding peptide for the prevention or treatment of diseases

<130> r71198

<150> EP16173740.8
<151> 2016-06-09

<160> 46

<170> BiSSAP 1.3

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus sequence

<220> 
<221> VARIANT
<222> 8..10
<223> X is any amino acid

<400> 1
Ser Phe Asn Pro Tyr Glu Pro Xaa Xaa Xaa 
1               5                   10  

<210> 2
<211> 10
<212> PRT
<213> Mus musculus

<220> 
<223> also in Rattus norvegicus

<400> 2
Ser Phe Asn Pro Tyr Glu Pro Thr Gly Gly 
1               5                   10  

<210> 3
<211> 10
<212> PRT
<213> Macaca mulatta

<400> 3
Ser Phe Asn Pro Tyr Glu Pro Glu Val Ala 
1               5                   10  

<210> 4
<211> 10
<212> PRT
<213> Homo sapiens

<400> 4
Ser Phe Asn Pro Tyr Glu Pro Glu Leu Ala 
1               5                   10  

<210> 5
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus sequence

<220> 
<221> VARIANT
<222> 11,12,13,14,16
<223> X is any amino acid

<400> 5
Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Xaa Xaa Xaa Xaa Trp Xaa 
1               5                   10                  15      



<210> 6
<211> 16
<212> PRT
<213> Mus musculus

<400> 6
Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Thr Gly Gly Pro Trp Gly 
1               5                   10                  15      



<210> 7
<211> 16
<212> PRT
<213> Rattus norvegicus

<400> 7
Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Thr Gly Gly Ala Trp Gly 
1               5                   10                  15      



<210> 8
<211> 16
<212> PRT
<213> Macaca mulatta

<400> 8
Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Glu Val Ala Pro Trp Ala 
1               5                   10                  15      



<210> 9
<211> 16
<212> PRT
<213> Homo sapiens

<400> 9
Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala 
1               5                   10                  15      



<210> 10
<211> 17
<212> PRT
<213> Drosophila melanogaster

<400> 10
Asp Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      
Lys 
    

<210> 11
<211> 13
<212> PRT
<213> Human immunodeficiency virus 1

<400> 11
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              

<210> 12
<211> 27
<212> PRT
<213> Mammalia

<400> 12
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      
Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          

<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<221> REPEAT
<222> 1-11
<223> 1 to 5 times repeat

<220> 
<223> consensus sequence

<220> 
<221> VARIANT
<222> 10
<223> X is K or R

<400> 13
Lys Lys Asp Lys Lys Asp Glu Arg Arg Xaa Lys 
1               5                   10      

<210> 14
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<221> REPEAT
<222> 1..11
<223> 1 to 5 times repeat

<220> 
<223> consensus sequence

<220> 
<221> VARIANT
<222> 5
<223> X is V, I or T

<400> 14
Lys Ile Lys Lys Xaa Asx Lys Lys Lys Gly Arg Lys 
1               5                   10          

<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence motif

<220> 
<221> VARIANT
<222> 1
<223> X is N or D

<220> 
<221> VARIANT
<222> 2,4
<223> X is any amino acid

<220> 
<221> MOD_RES
<222> 3
<223> PHOSPHORYLATION

<400> 15
Xaa Xaa Tyr Xaa Pro 
1               5   

<210> 16
<211> 5
<212> PRT
<213> Mus musculus

<220> 
<223> and in Homo sapiens

<400> 16
Asp Gly Tyr Thr Pro 
1               5   

<210> 17
<211> 5
<212> PRT
<213> Mus musculus

<220> 
<223> and in Homo sapiens

<400> 17
Asp Gly Tyr Met Pro 
1               5   

<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting Clec4n

<400> 18
ctgcccaaat cactggaagt                                                20


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting Clec4n

<400> 19
gaaattctgc tccgcttcag                                                20


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting Clec7a

<400> 20
gaaccacaag cccacagaat                                                20


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting Clec7a

<400> 21
taggaaggca aggctgagaa                                                20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting Clec4d

<400> 22
tacgctggac gagaggaagt                                                20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting Clec4d

<400> 23
acaggacagc aggtccaagt                                                20


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting Clec4e

<400> 24
caagtgctct cctggacgat                                                20


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting Clec4e

<400> 25
ctgtaagttc tgcccggaaa                                                20


<210> 26
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting TNF

<400> 26
caaaattcga gtgacaagcc tg                                             22


<210> 27
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting TNF

<400> 27
gagatccatg ccgttggc                                                  18


<210> 28
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting IL-6

<400> 28
gaggatacca ctcccaacag acc                                            23


<210> 29
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting IL-6

<400> 29
aagtgcatca tcgttgttca taca                                           24


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting IL-12

<400> 30
ggaagcacgg cagcagaata                                                20


<210> 31
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting IL-12

<400> 31
aacttgaggg agaagtagga atgg                                           24


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting IL-23

<400> 32
gcagattcca agcctcagtc                                                20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting IL-23

<400> 33
ttcaacatat gcaggtccca                                                20


<210> 34
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting IL-1beta

<400> 34
caaccaacaa gtgatattct ccatg                                          25


<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> targeting IL-1beta

<400> 35
gatccacact ctccagctgc a                                              21


<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> peptide

<400> 36
Phe Ala Gly Lys Gln Leu Glu Asp 
1               5               

<210> 37
<211> 97
<212> DNA
<213> Artificial Sequence

<220> 
<223> 97mer oligonucleotide for generation of shRNAs targeting cbl

<400> 37
tgctgttgac agtgagcgct acgacgatga tgatgatgaa tagtgaagcc acagatgtat     60

tcatcatcat catcgtcgta atgcctactg cctcgga                              97


<210> 38
<211> 97
<212> DNA
<213> Artificial Sequence

<220> 
<223> 97mer oligonucleotide for generation of shRNAs targeting renilla
      luciferase

<400> 38
tgctgttgac agtgagcgca ggaattataa tgcttatcta tagtgaagcc acagatgtat     60

agataagcat tataattcct atgcctactg cctcgga                              97


<210> 39
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> mir-E fwd

<400> 39
agaaggctcg agaaggtata ttgc                                           24


<210> 40
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> mir-E rev

<400> 40
gctcgaattc tagccccttg aagtccgagg                                     30


<210> 41
<211> 33
<212> PRT
<213> Mus musculus

<220> 
<223> antennapedia CPP - CBL-B TKB domain binding peptide

<220> 
<221> MOD_RES
<222> 25
<223> PHOSPHORYLATION

<400> 41
Asp Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      
Lys Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Thr Gly Gly Pro Trp 
            20                  25                  30          
Gly 
    

<210> 42
<211> 33
<212> PRT
<213> Mus musculus

<220> 
<221> MOD_RES
<222> 25
<223> PHOSPHORYLATION

<400> 42
Asp Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      
Lys Ser Thr Pro Asn Phe Gly Val Tyr Gly Thr Ser Pro Trp Gly Pro 
            20                  25                  30          
Glu 
    

<210> 43
<211> 38
<212> PRT
<213> Mus musculus

<220> 
<221> MOD_RES
<222> 30
<223> PHOSPHORYLATION

<400> 43
Lys Ile Lys Lys Thr Lys Lys Lys Gly Arg Lys Lys Ile Lys Lys Thr 
1               5                   10                  15      
Lys Lys Lys Gly Arg Lys Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro 
            20                  25                  30          
Thr Gly Gly Pro Trp Gly 
        35              

<210> 44
<211> 38
<212> PRT
<213> Mus musculus

<220> 
<221> MOD_RES
<222> 30
<223> PHOSPHORYLATION

<400> 44
Lys Ile Lys Lys Thr Lys Lys Lys Gly Arg Lys Lys Ile Lys Lys Thr 
1               5                   10                  15      
Lys Lys Lys Gly Arg Lys Ser Thr Pro Asn Phe Gly Val Tyr Gly Thr 
            20                  25                  30          
Ser Pro Trp Gly Pro Glu 
        35              

<210> 45
<211> 33
<212> PRT
<213> Homo sapiens

<220> 
<221> MOD_RES
<222> 25
<223> PHOSPHORYLATION

<400> 45
Asp Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      
Lys Ser Thr Val Ser Phe Asn Pro Tyr Glu Pro Glu Leu Ala Pro Trp 
            20                  25                  30          
Ala 
    

<210> 46
<211> 34
<212> PRT
<213> Homo sapiens

<220> 
<221> MOD_RES
<222> 26
<223> PHOSPHORYLATION

<400> 46
Asp Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      
Lys Glu Ala Val Pro Leu Tyr Ala Trp Tyr Pro Asn Pro Ser Thr Phe 
            20                  25                  30          
Glu Ser 
        

