                         SEQUENCE LISTING

<110>  VIB VZW
       KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
 
<120>  MEANS AND METHODS TO TREAT DYSTONIA

<130>  RG/LIPIN/554

<150>  EP 16173092.4
<151>  2016-06-06

<150>  EP 16183216.7
<151>  2016-08-08

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Tyr Val Gly Gln Leu Ala Gly Gln Val Phe Val Thr Val Lys 
1               5                   10                  15      


Glu Leu Tyr Lys Gly Leu Asn Pro Ala Thr Leu Ser Gly Cys Ile Asp 
            20                  25                  30          


Ile Ile Val Ile Arg Gln Pro Asn Gly Asn Leu Gln Cys Ser Pro Phe 
        35                  40                  45              


His Val Arg Phe Gly Lys Met Gly Val Leu Arg Ser Arg Glu Lys Val 
    50                  55                  60                  


Val Asp Ile Glu Ile Asn Gly Glu Ser Val Asp Leu His Met Lys Leu 
65                  70                  75                  80  


Gly Asp Asn Gly Glu Ala Phe Phe Val Gln Glu Thr Asp Asn Asp Gln 
                85                  90                  95      


Glu Val Ile Pro Met His Leu Ala Thr Ser Pro Ile Leu Ser Glu Gly 
            100                 105                 110         


Ala Ser Arg Met Glu Cys Gln Leu Lys Arg Gly Ser Val Asp Arg Met 
        115                 120                 125             


Arg Gly Leu Asp Pro Ser Thr Pro Ala Gln Val Ile Ala Pro Ser Glu 
    130                 135                 140                 


Thr Pro Ser Ser Ser Ser Val Val Lys Lys Arg Arg Lys Arg Arg Arg 
145                 150                 155                 160 


Lys Ser Gln Leu Asp Ser Leu Lys Arg Asp Asp Asn Met Asn Thr Ser 
                165                 170                 175     


Glu Asp Glu Asp Met Phe Pro Ile Glu Met Ser Ser Asp Glu Ala Met 
            180                 185                 190         


Glu Leu Leu Glu Ser Ser Arg Thr Leu Pro Asn Asp Ile Pro Pro Phe 
        195                 200                 205             


Gln Asp Asp Ile Pro Glu Glu Asn Leu Ser Leu Ala Val Ile Tyr Pro 
    210                 215                 220                 


Gln Ser Ala Ser Tyr Pro Asn Ser Asp Arg Glu Trp Ser Pro Thr Pro 
225                 230                 235                 240 


Ser Pro Ser Gly Ser Arg Pro Ser Thr Pro Lys Ser Asp Ser Glu Leu 
                245                 250                 255     


Val Ser Lys Ser Thr Glu Arg Thr Gly Gln Lys Asn Pro Glu Met Leu 
            260                 265                 270         


Trp Leu Trp Gly Glu Leu Pro Gln Ala Ala Lys Ser Ser Ser Pro His 
        275                 280                 285             


Lys Met Lys Glu Ser Ser Pro Leu Ser Ser Arg Lys Ile Cys Asp Lys 
    290                 295                 300                 


Ser His Phe Gln Ala Ile His Ser Glu Ser Ser Asp Thr Phe Ser Asp 
305                 310                 315                 320 


Gln Ser Pro Thr Leu Val Gly Gly Ala Leu Leu Asp Gln Asn Lys Pro 
                325                 330                 335     


Gln Thr Glu Met Gln Phe Val Asn Glu Glu Asp Leu Glu Thr Leu Gly 
            340                 345                 350         


Ala Ala Ala Pro Leu Leu Pro Met Ile Glu Glu Leu Lys Pro Pro Ser 
        355                 360                 365             


Ala Ser Val Val Gln Thr Ala Asn Lys Thr Asp Ser Pro Ser Arg Lys 
    370                 375                 380                 


Arg Asp Lys Arg Ser Arg His Leu Gly Ala Asp Gly Val Tyr Leu Asp 
385                 390                 395                 400 


Asp Leu Thr Asp Met Asp Pro Glu Val Ala Ala Leu Tyr Phe Pro Lys 
                405                 410                 415     


Asn Gly Asp Pro Ser Gly Leu Ala Lys His Ala Ser Asp Asn Gly Ala 
            420                 425                 430         


Arg Ser Ala Asn Gln Ser Pro Gln Ser Val Gly Ser Ser Gly Val Asp 
        435                 440                 445             


Ser Gly Val Glu Ser Thr Ser Asp Gly Leu Arg Asp Leu Pro Ser Ile 
    450                 455                 460                 


Ala Ile Ser Leu Cys Gly Gly Leu Ser Asp His Arg Glu Ile Thr Lys 
465                 470                 475                 480 


Asp Ala Phe Leu Glu Gln Ala Val Ser Tyr Gln Gln Phe Val Asp Asn 
                485                 490                 495     


Pro Ala Ile Ile Asp Asp Pro Asn Leu Val Val Lys Ile Gly Ser Lys 
            500                 505                 510         


Tyr Tyr Asn Trp Thr Thr Ala Ala Pro Leu Leu Leu Ala Met Gln Ala 
        515                 520                 525             


Phe Gln Lys Pro Leu Pro Lys Ala Thr Val Glu Ser Ile Met Arg Asp 
    530                 535                 540                 


Lys Met Pro Lys Lys Gly Gly Arg Trp Trp Phe Ser Trp Arg Gly Arg 
545                 550                 555                 560 


Asn Thr Thr Ile Lys Glu Glu Ser Lys Pro Glu Gln Cys Leu Ala Gly 
                565                 570                 575     


Lys Ala His Ser Thr Gly Glu Gln Pro Pro Gln Leu Ser Leu Ala Thr 
            580                 585                 590         


Arg Val Lys His Glu Ser Ser Ser Ser Asp Glu Glu Arg Ala Ala Ala 
        595                 600                 605             


Lys Pro Ser Asn Ala Gly His Leu Pro Leu Leu Pro Asn Val Ser Tyr 
    610                 615                 620                 


Lys Lys Thr Leu Arg Leu Thr Ser Glu Gln Leu Lys Ser Leu Lys Leu 
625                 630                 635                 640 


Lys Asn Gly Pro Asn Asp Val Val Phe Ser Val Thr Thr Gln Tyr Gln 
                645                 650                 655     


Gly Thr Cys Arg Cys Glu Gly Thr Ile Tyr Leu Trp Asn Trp Asp Asp 
            660                 665                 670         


Lys Val Ile Ile Ser Asp Ile Asp Gly Thr Ile Thr Arg Ser Asp Thr 
        675                 680                 685             


Leu Gly His Ile Leu Pro Thr Leu Gly Lys Asp Trp Thr His Gln Gly 
    690                 695                 700                 


Ile Ala Lys Leu Tyr His Lys Val Ser Gln Asn Gly Tyr Lys Phe Leu 
705                 710                 715                 720 


Tyr Cys Ser Ala Arg Ala Ile Gly Met Ala Asp Met Thr Arg Gly Tyr 
                725                 730                 735     


Leu His Trp Val Asn Glu Arg Gly Thr Val Leu Pro Gln Gly Pro Leu 
            740                 745                 750         


Leu Leu Ser Pro Ser Ser Leu Phe Ser Ala Leu His Arg Glu Val Ile 
        755                 760                 765             


Glu Lys Lys Pro Glu Lys Phe Lys Val Gln Cys Leu Thr Asp Ile Lys 
    770                 775                 780                 


Asn Leu Phe Phe Pro Asn Thr Glu Pro Phe Tyr Ala Ala Phe Gly Asn 
785                 790                 795                 800 


Arg Pro Ala Asp Val Tyr Ser Tyr Lys Gln Val Gly Val Ser Leu Asn 
                805                 810                 815     


Arg Ile Phe Thr Val Asn Pro Lys Gly Glu Leu Val Gln Glu His Ala 
            820                 825                 830         


Lys Thr Asn Ile Ser Ser Tyr Val Arg Leu Cys Glu Val Val Asp His 
        835                 840                 845             


Val Phe Pro Leu Leu Lys Arg Ser His Ser Ser Asp Phe Pro Cys Ser 
    850                 855                 860                 


Asp Thr Phe Ser Asn Phe Thr Phe Trp Arg Glu Pro Leu Pro Pro Phe 
865                 870                 875                 880 


Glu Asn Gln Asp Ile His Ser Ala Ser Ala 
                885                 890 


<210>  2
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Arg Val Gln Thr Met Asn Tyr Val Gly Gln Leu Ala Gly Gln 
1               5                   10                  15      


Val Phe Val Thr Val Lys Glu Leu Tyr Lys Gly Leu Asn Pro Ala Thr 
            20                  25                  30          


Leu Ser Gly Cys Ile Asp Ile Ile Val Ile Arg Gln Pro Asn Gly Asn 
        35                  40                  45              


Leu Gln Cys Ser Pro Phe His Val Arg Phe Gly Lys Met Gly Val Leu 
    50                  55                  60                  


Arg Ser Arg Glu Lys Val Val Asp Ile Glu Ile Asn Gly Glu Ser Val 
65                  70                  75                  80  


Asp Leu His Met Lys Leu Gly Asp Asn Gly Glu Ala Phe Phe Val Gln 
                85                  90                  95      


Glu Thr Asp Asn Asp Gln Glu Val Ile Pro Met His Leu Ala Thr Ser 
            100                 105                 110         


Pro Ile Leu Ser Glu Gly Ala Ser Arg Met Glu Cys Gln Leu Lys Arg 
        115                 120                 125             


Gly Ser Val Asp Arg Met Arg Gly Leu Asp Pro Ser Thr Pro Ala Gln 
    130                 135                 140                 


Val Ile Ala Pro Ser Glu Thr Pro Ser Ser Ser Ser Val Val Lys Lys 
145                 150                 155                 160 


Arg Arg Lys Arg Arg Arg Lys Ser Gln Leu Asp Ser Leu Lys Arg Asp 
                165                 170                 175     


Asp Asn Met Asn Thr Ser Glu Asp Glu Asp Met Phe Pro Ile Glu Met 
            180                 185                 190         


Ser Ser Asp Glu Ala Met Glu Leu Leu Glu Ser Ser Arg Thr Leu Pro 
        195                 200                 205             


Asn Asp Ile Pro Pro Phe Gln Asp Asp Ile Pro Glu Glu Asn Leu Ser 
    210                 215                 220                 


Leu Ala Val Ile Tyr Pro Gln Ser Ala Ser Tyr Pro Asn Ser Asp Arg 
225                 230                 235                 240 


Glu Trp Ser Pro Thr Pro Ser Pro Ser Gly Ser Arg Pro Ser Thr Pro 
                245                 250                 255     


Lys Ser Asp Ser Glu Leu Val Ser Lys Ser Thr Glu Arg Thr Gly Gln 
            260                 265                 270         


Lys Asn Pro Glu Met Leu Trp Leu Trp Gly Glu Leu Pro Gln Ala Ala 
        275                 280                 285             


Lys Ser Ser Ser Pro His Lys Met Lys Glu Ser Ser Pro Leu Ser Ser 
    290                 295                 300                 


Arg Lys Ile Cys Asp Lys Ser His Phe Gln Ala Ile His Ser Glu Ser 
305                 310                 315                 320 


Ser Asp Thr Phe Ser Asp Gln Ser Pro Thr Leu Val Gly Gly Ala Leu 
                325                 330                 335     


Leu Asp Gln Asn Lys Pro Gln Thr Glu Met Gln Phe Val Asn Glu Glu 
            340                 345                 350         


Asp Leu Glu Thr Leu Gly Ala Ala Ala Pro Leu Leu Pro Met Ile Glu 
        355                 360                 365             


Glu Leu Lys Pro Pro Ser Ala Ser Val Val Gln Thr Ala Asn Lys Thr 
    370                 375                 380                 


Asp Ser Pro Ser Arg Lys Arg Asp Lys Arg Ser Arg His Leu Gly Ala 
385                 390                 395                 400 


Asp Gly Val Tyr Leu Asp Asp Leu Thr Asp Met Asp Pro Glu Val Ala 
                405                 410                 415     


Ala Leu Tyr Phe Pro Lys Asn Gly Asp Pro Ser Gly Leu Ala Lys His 
            420                 425                 430         


Ala Ser Asp Asn Gly Ala Arg Ser Ala Asn Gln Ser Pro Gln Ser Val 
        435                 440                 445             


Gly Ser Ser Gly Val Asp Ser Gly Val Glu Ser Thr Ser Asp Gly Leu 
    450                 455                 460                 


Arg Asp Leu Pro Ser Ile Ala Ile Ser Leu Cys Gly Gly Leu Ser Asp 
465                 470                 475                 480 


His Arg Glu Ile Thr Lys Asp Ala Phe Leu Glu Gln Ala Val Ser Tyr 
                485                 490                 495     


Gln Gln Phe Val Asp Asn Pro Ala Ile Ile Asp Asp Pro Asn Leu Val 
            500                 505                 510         


Val Lys Ile Gly Ser Lys Tyr Tyr Asn Trp Thr Thr Ala Ala Pro Leu 
        515                 520                 525             


Leu Leu Ala Met Gln Ala Phe Gln Lys Pro Leu Pro Lys Ala Thr Val 
    530                 535                 540                 


Glu Ser Ile Met Arg Asp Lys Met Pro Lys Lys Gly Gly Arg Trp Trp 
545                 550                 555                 560 


Phe Ser Trp Arg Gly Arg Asn Thr Thr Ile Lys Glu Glu Ser Lys Pro 
                565                 570                 575     


Glu Gln Cys Leu Ala Gly Lys Ala His Ser Thr Gly Glu Gln Pro Pro 
            580                 585                 590         


Gln Leu Ser Leu Ala Thr Arg Val Lys His Glu Ser Ser Ser Ser Asp 
        595                 600                 605             


Glu Glu Arg Ala Ala Ala Lys Pro Ser Asn Ala Gly His Leu Pro Leu 
    610                 615                 620                 


Leu Pro Asn Val Ser Tyr Lys Lys Thr Leu Arg Leu Thr Ser Glu Gln 
625                 630                 635                 640 


Leu Lys Ser Leu Lys Leu Lys Asn Gly Pro Asn Asp Val Val Phe Ser 
                645                 650                 655     


Val Thr Thr Gln Tyr Gln Gly Thr Cys Arg Cys Glu Gly Thr Ile Tyr 
            660                 665                 670         


Leu Trp Asn Trp Asp Asp Lys Val Ile Ile Ser Asp Ile Asp Gly Thr 
        675                 680                 685             


Ile Thr Arg Ser Asp Thr Leu Gly His Ile Leu Pro Thr Leu Gly Lys 
    690                 695                 700                 


Asp Trp Thr His Gln Gly Ile Ala Lys Leu Tyr His Lys Val Ser Gln 
705                 710                 715                 720 


Asn Gly Tyr Lys Phe Leu Tyr Cys Ser Ala Arg Ala Ile Gly Met Ala 
                725                 730                 735     


Asp Met Thr Arg Gly Tyr Leu His Trp Val Asn Glu Arg Gly Thr Val 
            740                 745                 750         


Leu Pro Gln Gly Pro Leu Leu Leu Ser Pro Ser Ser Leu Phe Ser Ala 
        755                 760                 765             


Leu His Arg Glu Val Ile Glu Lys Lys Pro Glu Lys Phe Lys Val Gln 
    770                 775                 780                 


Cys Leu Thr Asp Ile Lys Asn Leu Phe Phe Pro Asn Thr Glu Pro Phe 
785                 790                 795                 800 


Tyr Ala Ala Phe Gly Asn Arg Pro Ala Asp Val Tyr Ser Tyr Lys Gln 
                805                 810                 815     


Val Gly Val Ser Leu Asn Arg Ile Phe Thr Val Asn Pro Lys Gly Glu 
            820                 825                 830         


Leu Val Gln Glu His Ala Lys Thr Asn Ile Ser Ser Tyr Val Arg Leu 
        835                 840                 845             


Cys Glu Val Val Asp His Val Phe Pro Leu Leu Lys Arg Ser His Ser 
    850                 855                 860                 


Ser Asp Phe Pro Cys Ser Asp Thr Phe Ser Asn Phe Thr Phe Trp Arg 
865                 870                 875                 880 


Glu Pro Leu Pro Pro Phe Glu Asn Gln Asp Ile His Ser Ala Ser Ala 
                885                 890                 895     


<210>  3
<211>  975
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Glu Gln Asp Gly Ile Arg Ser Ser Ser Trp Glu Thr Ser Gln 
1               5                   10                  15      


Gly Lys Ser Ser Pro Asp Ser Ala Trp Ser Trp Ile Pro Ile Met Arg 
            20                  25                  30          


Asp Pro Gly Trp Ile Arg Asn Val Trp Ser Ser Asn Ile Asn Val Gln 
        35                  40                  45              


Thr Met Asn Tyr Val Gly Gln Leu Ala Gly Gln Val Phe Val Thr Val 
    50                  55                  60                  


Lys Glu Leu Tyr Lys Gly Leu Asn Pro Ala Thr Leu Ser Gly Cys Ile 
65                  70                  75                  80  


Asp Ile Ile Val Ile Arg Gln Pro Asn Gly Asn Leu Gln Cys Ser Pro 
                85                  90                  95      


Phe His Val Arg Phe Gly Lys Met Gly Val Leu Arg Ser Arg Glu Lys 
            100                 105                 110         


Val Val Asp Ile Glu Ile Asn Gly Glu Ser Val Asp Leu His Met Lys 
        115                 120                 125             


Leu Gly Asp Asn Gly Glu Ala Phe Phe Val Gln Glu Thr Asp Asn Asp 
    130                 135                 140                 


Gln Glu Val Ile Pro Met His Leu Ala Thr Ser Pro Ile Leu Ser Glu 
145                 150                 155                 160 


Gly Ala Ser Arg Met Glu Cys Gln Leu Lys Arg Gly Ser Val Asp Arg 
                165                 170                 175     


Met Arg Gly Leu Asp Pro Ser Thr Pro Ala Gln Val Ile Ala Pro Ser 
            180                 185                 190         


Glu Thr Pro Ser Ser Ser Ser Val Val Lys Lys Arg Arg Lys Arg Arg 
        195                 200                 205             


Arg Lys Ser Gln Leu Asp Ser Leu Lys Arg Asp Asp Asn Met Asn Thr 
    210                 215                 220                 


Ser Glu Asp Glu Asp Met Phe Pro Ile Glu Met Ser Ser Asp Glu Ala 
225                 230                 235                 240 


Met Glu Leu Leu Glu Ser Ser Arg Thr Leu Pro Asn Asp Ile Pro Pro 
                245                 250                 255     


Phe Gln Asp Asp Ile Pro Glu Glu Asn Leu Ser Leu Ala Val Ile Tyr 
            260                 265                 270         


Pro Gln Ser Ala Ser Tyr Pro Asn Ser Asp Arg Glu Trp Ser Pro Thr 
        275                 280                 285             


Pro Ser Ser Leu Val Asp Cys Lys Arg Thr Ala Pro His Leu Ala Val 
    290                 295                 300                 


Ala Ala Glu Gly Gly Leu Ser Ser Ser Cys Pro Pro Gln Ser Ser Leu 
305                 310                 315                 320 


Phe His Pro Ser Glu Ser Pro Ser Gly Ser Arg Pro Ser Thr Pro Lys 
                325                 330                 335     


Ser Asp Ser Glu Leu Val Ser Lys Ser Thr Glu Arg Thr Gly Gln Lys 
            340                 345                 350         


Asn Pro Glu Met Leu Trp Leu Trp Gly Glu Leu Pro Gln Ala Ala Lys 
        355                 360                 365             


Ser Ser Ser Pro His Lys Met Lys Glu Ser Ser Pro Leu Ser Ser Arg 
    370                 375                 380                 


Lys Ile Cys Asp Lys Ser His Phe Gln Ala Ile His Ser Glu Ser Ser 
385                 390                 395                 400 


Asp Thr Phe Ser Asp Gln Ser Pro Thr Leu Val Gly Gly Ala Leu Leu 
                405                 410                 415     


Asp Gln Asn Lys Pro Gln Thr Glu Met Gln Phe Val Asn Glu Glu Asp 
            420                 425                 430         


Leu Glu Thr Leu Gly Ala Ala Ala Pro Leu Leu Pro Met Ile Glu Glu 
        435                 440                 445             


Leu Lys Pro Pro Ser Ala Ser Val Val Gln Thr Ala Asn Lys Thr Asp 
    450                 455                 460                 


Ser Pro Ser Arg Lys Arg Asp Lys Arg Ser Arg His Leu Gly Ala Asp 
465                 470                 475                 480 


Gly Val Tyr Leu Asp Asp Leu Thr Asp Met Asp Pro Glu Val Ala Ala 
                485                 490                 495     


Leu Tyr Phe Pro Lys Asn Gly Asp Pro Ser Gly Leu Ala Lys His Ala 
            500                 505                 510         


Ser Asp Asn Gly Ala Arg Ser Ala Asn Gln Ser Pro Gln Ser Val Gly 
        515                 520                 525             


Ser Ser Gly Val Asp Ser Gly Val Glu Ser Thr Ser Asp Gly Leu Arg 
    530                 535                 540                 


Asp Leu Pro Ser Ile Ala Ile Ser Leu Cys Gly Gly Leu Ser Asp His 
545                 550                 555                 560 


Arg Glu Ile Thr Lys Asp Ala Phe Leu Glu Gln Ala Val Ser Tyr Gln 
                565                 570                 575     


Gln Phe Val Asp Asn Pro Ala Ile Ile Asp Asp Pro Asn Leu Val Val 
            580                 585                 590         


Lys Ile Gly Ser Lys Tyr Tyr Asn Trp Thr Thr Ala Ala Pro Leu Leu 
        595                 600                 605             


Leu Ala Met Gln Ala Phe Gln Lys Pro Leu Pro Lys Ala Thr Val Glu 
    610                 615                 620                 


Ser Ile Met Arg Asp Lys Met Pro Lys Lys Gly Gly Arg Trp Trp Phe 
625                 630                 635                 640 


Ser Trp Arg Gly Arg Asn Thr Thr Ile Lys Glu Glu Ser Lys Pro Glu 
                645                 650                 655     


Gln Cys Leu Ala Gly Lys Ala His Ser Thr Gly Glu Gln Pro Pro Gln 
            660                 665                 670         


Leu Ser Leu Ala Thr Arg Val Lys His Glu Ser Ser Ser Ser Asp Glu 
        675                 680                 685             


Glu Arg Ala Ala Ala Lys Pro Ser Asn Ala Gly His Leu Pro Leu Leu 
    690                 695                 700                 


Pro Asn Val Ser Tyr Lys Lys Thr Leu Arg Leu Thr Ser Glu Gln Leu 
705                 710                 715                 720 


Lys Ser Leu Lys Leu Lys Asn Gly Pro Asn Asp Val Val Phe Ser Val 
                725                 730                 735     


Thr Thr Gln Tyr Gln Gly Thr Cys Arg Cys Glu Gly Thr Ile Tyr Leu 
            740                 745                 750         


Trp Asn Trp Asp Asp Lys Val Ile Ile Ser Asp Ile Asp Gly Thr Ile 
        755                 760                 765             


Thr Arg Ser Asp Thr Leu Gly His Ile Leu Pro Thr Leu Gly Lys Asp 
    770                 775                 780                 


Trp Thr His Gln Gly Ile Ala Lys Leu Tyr His Lys Val Ser Gln Asn 
785                 790                 795                 800 


Gly Tyr Lys Phe Leu Tyr Cys Ser Ala Arg Ala Ile Gly Met Ala Asp 
                805                 810                 815     


Met Thr Arg Gly Tyr Leu His Trp Val Asn Glu Arg Gly Thr Val Leu 
            820                 825                 830         


Pro Gln Gly Pro Leu Leu Leu Ser Pro Ser Ser Leu Phe Ser Ala Leu 
        835                 840                 845             


His Arg Glu Val Ile Glu Lys Lys Pro Glu Lys Phe Lys Val Gln Cys 
    850                 855                 860                 


Leu Thr Asp Ile Lys Asn Leu Phe Phe Pro Asn Thr Glu Pro Phe Tyr 
865                 870                 875                 880 


Ala Ala Phe Gly Asn Arg Pro Ala Asp Val Tyr Ser Tyr Lys Gln Val 
                885                 890                 895     


Gly Val Ser Leu Asn Arg Ile Phe Thr Val Asn Pro Lys Gly Glu Leu 
            900                 905                 910         


Val Gln Glu His Ala Lys Thr Asn Ile Ser Ser Tyr Val Arg Leu Cys 
        915                 920                 925             


Glu Val Val Asp His Val Phe Pro Leu Leu Lys Arg Ser His Ser Ser 
    930                 935                 940                 


Asp Phe Pro Cys Ser Asp Thr Phe Ser Asn Phe Thr Phe Trp Arg Glu 
945                 950                 955                 960 


Pro Leu Pro Pro Phe Glu Asn Gln Asp Ile His Ser Ala Ser Ala 
                965                 970                 975 


<210>  4
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Arg Val Gln Thr Met Asn Tyr Val Gly Gln Leu Ala Gly Gln 
1               5                   10                  15      


Val Phe Val Thr Val Lys Glu Leu Tyr Lys Gly Leu Asn Pro Ala Thr 
            20                  25                  30          


Leu Ser Gly Cys Ile Asp Ile Ile Val Ile Arg Gln Pro Asn Gly Asn 
        35                  40                  45              


Leu Gln Cys Ser Pro Phe His Val Arg Phe Gly Lys Met Gly Val Leu 
    50                  55                  60                  


Arg Ser Arg Glu Lys Val Val Asp Ile Glu Ile Asn Gly Glu Ser Val 
65                  70                  75                  80  


Asp Leu His Met Lys Leu Gly Asp Asn Gly Glu Ala Phe Phe Val Gln 
                85                  90                  95      


Glu Thr Asp Asn Asp Gln Glu Val Ile Pro Met His Leu Ala Thr Ser 
            100                 105                 110         


Pro Ile Leu Ser Glu Gly Ala Ser Arg Met Glu Cys Gln Leu Lys Arg 
        115                 120                 125             


Gly Ser Val Asp Arg Met Arg Gly Leu Asp Pro Ser Thr Pro Ala Gln 
    130                 135                 140                 


Val Ile Ala Pro Ser Glu Thr Pro Ser Ser Ser Ser Val Val Lys Lys 
145                 150                 155                 160 


Arg Arg Lys Arg Arg Arg Lys Ser Gln Leu Asp Ser Leu Lys Arg Asp 
                165                 170                 175     


Asp Asn Met Asn Thr Ser Glu Asp Glu Asp Met Phe Pro Ile Glu Met 
            180                 185                 190         


Ser Ser Asp Glu Ala Met Glu Leu Leu Glu Ser Ser Arg Thr Leu Pro 
        195                 200                 205             


Asn Asp Ile Pro Pro Phe Gln Asp Asp Ile Pro Glu Glu Asn Leu Ser 
    210                 215                 220                 


Leu Ala Val Ile Tyr Pro Gln Ser Ala Ser Tyr Pro Asn Ser Asp Arg 
225                 230                 235                 240 


Glu Trp Ser Pro Thr Pro Ser Ser Leu Val Asp Cys Lys Arg Thr Ala 
                245                 250                 255     


Pro His Leu Ala Val Ala Ala Glu Gly Gly Leu Ser Ser Ser Cys Pro 
            260                 265                 270         


Pro Gln Ser Ser Leu Phe His Pro Ser Glu Ser Pro Ser Gly Ser Arg 
        275                 280                 285             


Pro Ser Thr Pro Lys Ser Asp Ser Glu Leu Val Ser Lys Ser Thr Glu 
    290                 295                 300                 


Arg Thr Gly Gln Lys Asn Pro Glu Met Leu Trp Leu Trp Gly Glu Leu 
305                 310                 315                 320 


Pro Gln Ala Ala Lys Ser Ser Ser Pro His Lys Met Lys Glu Ser Ser 
                325                 330                 335     


Pro Leu Ser Ser Arg Lys Ile Cys Asp Lys Ser His Phe Gln Ala Ile 
            340                 345                 350         


His Ser Glu Ser Ser Asp Thr Phe Ser Asp Gln Ser Pro Thr Leu Val 
        355                 360                 365             


Gly Gly Ala Leu Leu Asp Gln Asn Lys Pro Gln Thr Glu Met Gln Phe 
    370                 375                 380                 


Val Asn Glu Glu Asp Leu Glu Thr Leu Gly Ala Ala Ala Pro Leu Leu 
385                 390                 395                 400 


Pro Met Ile Glu Glu Leu Lys Pro Pro Ser Ala Ser Val Val Gln Thr 
                405                 410                 415     


Ala Asn Lys Thr Asp Ser Pro Ser Arg Lys Arg Asp Lys Arg Ser Arg 
            420                 425                 430         


His Leu Gly Ala Asp Gly Val Tyr Leu Asp Asp Leu Thr Asp Met Asp 
        435                 440                 445             


Pro Glu Val Ala Ala Leu Tyr Phe Pro Lys Lys 
    450                 455                 


<210>  5
<211>  2117
<212>  DNA
<213>  Homo sapiens

<400>  5
gaaccggaag cgtgggtctg gcggctgcac cggttcgcgg tcggcgcgag aacaagcagg       60

gtggcgcggg tccgggcatg aagctgggcc gggccgtgct gggcctgctg ctgctggcgc      120

cgtccgtggt gcaggcggtg gagcccatca gcctgggact ggccctggcc ggcgtcctca      180

ccggctacat ctacccgcgt ctctactgcc tcttcgccga gtgctgcggg cagaagcgga      240

gccttagccg ggaggcactg cagaaggatc tggacgacaa cctctttgga cagcatcttg      300

caaagaaaat catcttaaat gccgtgtttg gtttcataaa caacccaaag cccaagaaac      360

ctctcacgct ctccctgcac gggtggacag gcaccggcaa aaatttcgtc agcaagatca      420

tcgcagagaa tatttacgag ggtggtctga acagtgacta tgtccacctg tttgtggcca      480

cattgcactt tccacatgct tcaaacatca ccttgtacaa ggatcagtta cagttgtgga      540

ttcgaggcaa cgtgagtgcc tgtgcgaggt ccatcttcat atttgatgaa atggataaga      600

tgcatgcagg cctcatagat gccatcaagc ctttcctcga ctattatgac ctggtggatg      660

gggtctccta ccagaaagcc atgttcatat ttctcagcaa tgctggagca gaaaggatca      720

cagatgtggc tttggatttc tggaggagtg gaaagcagag ggaagacatc aagctcaaag      780

acattgaaca cgcgttgtct gtgtcggttt tcaataacaa gaacagtggc ttctggcaca      840

gcagcttaat tgaccggaac ctcattgatt attttgttcc cttcctcccc ctggaataca      900

aacacctaaa aatgtgtatc cgagtggaaa tgcagtcccg aggctatgaa attgatgaag      960

acattgtaag cagagtggct gaggagatga catttttccc caaagaggag agagttttct     1020

cagataaagg ctgcaaaacg gtgttcacca agttagatta ttactacgat gattgacagt     1080

catgattggc agccggagtc actgcctgga gttggaaaag aaacaacact cagtccttcc     1140

acacttccac ccccagctcc tttccctgga agaggaatcc agtgaatgtt cctgtttgat     1200

gtgacaggaa ttctccctgg cattgtttcc accccctggt gcctgcaggc cacccaggga     1260

ccacgggcga ggacgtgaag cctcccgaac acgcacagaa ggaaggagcc agctcccagc     1320

ccactcatcg cagggctcat gattttttac aaattatgtt ttaattccaa gtgtttctgt     1380

ttcaaggaag gatgaataag ttttattgaa aatgtggtaa ctttatttaa aatgattttt     1440

aacattatga gagactgctc agattctaag ttgttggcct tgtgtgtgtg ttttttttta     1500

agttctcatc attattacat agactgtgat gtatctttac tggaaatgag cccaagcaca     1560

catgcatggc atttgttcca caggagggca tccctgggga tgtggctgga gcatgagcca     1620

gctctgtccc aggatggtcc cagcggatgc tgccaggggc agtgaagtgt ttaggtgaag     1680

gacaagtagg taagaggacg ccttcaggca ccacagataa gcctgaaaca gcctctccaa     1740

gggttttcac cttagcaaca atgggagctg tgggagtgat tttggccaca ctgtcaacat     1800

ttgttagaac cagtcttttg aaagaaaagt atttccaact tgtcacttgc cagtcactcc     1860

gttttgcaaa aggtggccct tcactgtcca ttccaaatag cccacacgtg ctctctgctg     1920

gattctaaat tatgtgaatt ttgccatatt aaatcttcct catttatact attatttgtt     1980

acgttcaatc agaatccccg aaacctccta taaagcttag ctgccccttc tgaggatgct     2040

gagaacggtg tctttcttta taaatgcaaa tggctaccgt tttacaataa aattttgcat     2100

gtgccaaaaa aaaaaaa                                                    2117


<210>  6
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Leu Gly Arg Ala Val Leu Gly Leu Leu Leu Leu Ala Pro Ser 
1               5                   10                  15      


Val Val Gln Ala Val Glu Pro Ile Ser Leu Gly Leu Ala Leu Ala Gly 
            20                  25                  30          


Val Leu Thr Gly Tyr Ile Tyr Pro Arg Leu Tyr Cys Leu Phe Ala Glu 
        35                  40                  45              


Cys Cys Gly Gln Lys Arg Ser Leu Ser Arg Glu Ala Leu Gln Lys Asp 
    50                  55                  60                  


Leu Asp Asp Asn Leu Phe Gly Gln His Leu Ala Lys Lys Ile Ile Leu 
65                  70                  75                  80  


Asn Ala Val Phe Gly Phe Ile Asn Asn Pro Lys Pro Lys Lys Pro Leu 
                85                  90                  95      


Thr Leu Ser Leu His Gly Trp Thr Gly Thr Gly Lys Asn Phe Val Ser 
            100                 105                 110         


Lys Ile Ile Ala Glu Asn Ile Tyr Glu Gly Gly Leu Asn Ser Asp Tyr 
        115                 120                 125             


Val His Leu Phe Val Ala Thr Leu His Phe Pro His Ala Ser Asn Ile 
    130                 135                 140                 


Thr Leu Tyr Lys Asp Gln Leu Gln Leu Trp Ile Arg Gly Asn Val Ser 
145                 150                 155                 160 


Ala Cys Ala Arg Ser Ile Phe Ile Phe Asp Glu Met Asp Lys Met His 
                165                 170                 175     


Ala Gly Leu Ile Asp Ala Ile Lys Pro Phe Leu Asp Tyr Tyr Asp Leu 
            180                 185                 190         


Val Asp Gly Val Ser Tyr Gln Lys Ala Met Phe Ile Phe Leu Ser Asn 
        195                 200                 205             


Ala Gly Ala Glu Arg Ile Thr Asp Val Ala Leu Asp Phe Trp Arg Ser 
    210                 215                 220                 


Gly Lys Gln Arg Glu Asp Ile Lys Leu Lys Asp Ile Glu His Ala Leu 
225                 230                 235                 240 


Ser Val Ser Val Phe Asn Asn Lys Asn Ser Gly Phe Trp His Ser Ser 
                245                 250                 255     


Leu Ile Asp Arg Asn Leu Ile Asp Tyr Phe Val Pro Phe Leu Pro Leu 
            260                 265                 270         


Glu Tyr Lys His Leu Lys Met Cys Ile Arg Val Glu Met Gln Ser Arg 
        275                 280                 285             


Gly Tyr Glu Ile Asp Glu Asp Ile Val Ser Arg Val Ala Glu Glu Met 
    290                 295                 300                 


Thr Phe Phe Pro Lys Glu Glu Arg Val Phe Ser Asp Lys Gly Cys Lys 
305                 310                 315                 320 


Thr Val Phe Thr Lys Leu Asp Tyr Tyr Tyr Asp Asp 
                325                 330         


<210>  7
<211>  2259
<212>  DNA
<213>  Homo sapiens

<400>  7
aggcggaact tccggctggc tcttccatca gctgccttcc ccgggcgtct ccccgcaacc       60

tcctcaactt ccctagtcag tgacgcggcg ccggccagaa atccgaccgg accgggctcg      120

ggggagcgtg agttgcagca tgtgccgaag cgccacctca gaagataaaa agaaatgagt      180

ctcatatttg gcattctttt agttaaaaga agatggatgc acagtgttca gccaaggtca      240

atgcaaggaa gaggagaaaa gaggcgcccg gacccaacgg ggcaacagaa gaagatgggg      300

ttccttccaa agtgcagcgc tgtgcagtgg gcttacggca accagctcct ttttctgatg      360

aaattgaagt tgactttagt aagccctatg tcagggtaac tatggaagaa gccagcagag      420

gaactccttg tgagcgacct gtgagagttt atgccgatgg aatatttgac ttatttcact      480

ctggtcacgc ccgagctctg atgcaagcga agaacctttt ccctaatacg tacctcattg      540

tgggagtttg cagtgatgag ctcacacaca acttcaaagg cttcacggtg atgaacgaga      600

atgagcgcta tgacgcagtc cagcactgcc gctacgtgga tgaggtggtg aggaatgcgc      660

cctggacgct gacacccgag ttcctggccg aacaccggat tgattttgta gcccatgatg      720

atattcctta ttcatctgct ggcagtgatg atgtttataa gcacatcaag gaggcaggca      780

tgtttgctcc aacacagagg acagaaggta tctccacatc agacatcatc acccgaattg      840

tgcgggatta tgatgtgtat gcgaggcgga acctgcagag gggctacaca gcaaaggagc      900

tcaatgtcag ctttatcaac gagaagaaat accacttgca ggagagggtt gacaaagtaa      960

agaagaaagt gaaagatgtg gaggaaaagt caaaagaatt tgttcagaag gtggaggaaa     1020

aaagcattga cctcattcag aagtgggagg agaagtcccg agaattcatt ggaagttttc     1080

tggaaatgtt tggtccggaa ggagcactga aacatatgct gaaagagggg aagggccgga     1140

tgctgcaggc catcagcccg aagcagagcc ccagcagcag ccctactcgc gagcgctccc     1200

cctccccctc tttccgatgg cccttctccg gcaagacttc cccaccttgc tccccagcaa     1260

atctctccag gcacaaggct gcagcctatg atatcagtga ggatgaagaa gactaatgtt     1320

tcctccctcc tttcctgtcc tccctttctg tcccattacc ttcagaagct ctctgttgaa     1380

ttccaaattg tgaccccaac actaaaccta aggacagcta caaaggaaag acaactgggg     1440

aaagaagacc taggactggg ggaacccaaa cagcctgtcc tgcaagtgac atcactcacc     1500

cacacgaagg agggggactg caccttagaa gcctgctctg catccattta ccccccccca     1560

agggctttgt ttcactgttt atgttcacgt gatctcaaca gggaaattgt cattttcatt     1620

aattttttaa aaaattcgtc tttcaaatgt agaactaatt ttttgcccct gaggagtggg     1680

cagaagaagg aggtagtgta atacgcagag gccttttctt cccggtatac tatagcattt     1740

gccttccgtt ctgaagctat gtggcttgcc aagtccttca cgaaatgagc cacgctgatg     1800

ggtaatttgt ggagaaatat cttaattttg atttccttaa ggaaaagcga aaagcagagt     1860

tacagtcaca aatcccctga acgtactgct gtcaccagtg tcattgtggc tgcgggaagg     1920

agatctgaac ctaacttttc ttactccctg aggagtttct tgttggaccc aatggggtcc     1980

atgaagacac tgatggggat ggaagcagac ccatggcatc aactgcagtg tttctgctgt     2040

gttcatcttc tcagaaaact ctgtgaccca gttctttggg agcttttgtc agtctctttc     2100

gtgccatcta ccttcgaagg aaggaacact tttagagtta caatgatgag gagaggagcg     2160

ggacaatact caatcctata ccaagtcgat tgagattagt ttcctactgg gagtaagtgc     2220

ctggccctgc tactcctatt tgaatgctat taatattac                            2259


<210>  8
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Ala Gln Cys Ser Ala Lys Val Asn Ala Arg Lys Arg Arg Lys 
1               5                   10                  15      


Glu Ala Pro Gly Pro Asn Gly Ala Thr Glu Glu Asp Gly Val Pro Ser 
            20                  25                  30          


Lys Val Gln Arg Cys Ala Val Gly Leu Arg Gln Pro Ala Pro Phe Ser 
        35                  40                  45              


Asp Glu Ile Glu Val Asp Phe Ser Lys Pro Tyr Val Arg Val Thr Met 
    50                  55                  60                  


Glu Glu Ala Ser Arg Gly Thr Pro Cys Glu Arg Pro Val Arg Val Tyr 
65                  70                  75                  80  


Ala Asp Gly Ile Phe Asp Leu Phe His Ser Gly His Ala Arg Ala Leu 
                85                  90                  95      


Met Gln Ala Lys Asn Leu Phe Pro Asn Thr Tyr Leu Ile Val Gly Val 
            100                 105                 110         


Cys Ser Asp Glu Leu Thr His Asn Phe Lys Gly Phe Thr Val Met Asn 
        115                 120                 125             


Glu Asn Glu Arg Tyr Asp Ala Val Gln His Cys Arg Tyr Val Asp Glu 
    130                 135                 140                 


Val Val Arg Asn Ala Pro Trp Thr Leu Thr Pro Glu Phe Leu Ala Glu 
145                 150                 155                 160 


His Arg Ile Asp Phe Val Ala His Asp Asp Ile Pro Tyr Ser Ser Ala 
                165                 170                 175     


Gly Ser Asp Asp Val Tyr Lys His Ile Lys Glu Ala Gly Met Phe Ala 
            180                 185                 190         


Pro Thr Gln Arg Thr Glu Gly Ile Ser Thr Ser Asp Ile Ile Thr Arg 
        195                 200                 205             


Ile Val Arg Asp Tyr Asp Val Tyr Ala Arg Arg Asn Leu Gln Arg Gly 
    210                 215                 220                 


Tyr Thr Ala Lys Glu Leu Asn Val Ser Phe Ile Asn Glu Lys Lys Tyr 
225                 230                 235                 240 


His Leu Gln Glu Arg Val Asp Lys Val Lys Lys Lys Val Lys Asp Val 
                245                 250                 255     


Glu Glu Lys Ser Lys Glu Phe Val Gln Lys Val Glu Glu Lys Ser Ile 
            260                 265                 270         


Asp Leu Ile Gln Lys Trp Glu Glu Lys Ser Arg Glu Phe Ile Gly Ser 
        275                 280                 285             


Phe Leu Glu Met Phe Gly Pro Glu Gly Ala Leu Lys His Met Leu Lys 
    290                 295                 300                 


Glu Gly Lys Gly Arg Met Leu Gln Ala Ile Ser Pro Lys Gln Ser Pro 
305                 310                 315                 320 


Ser Ser Ser Pro Thr Arg Glu Arg Ser Pro Ser Pro Ser Phe Arg Trp 
                325                 330                 335     


Pro Phe Ser Gly Lys Thr Ser Pro Pro Cys Ser Pro Ala Asn Leu Ser 
            340                 345                 350         


Arg His Lys Ala Ala Ala Tyr Asp Ile Ser Glu Asp Glu Glu Asp 
        355                 360                 365         


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
atgagtaatc tggcgagacg                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
actcaaatgg agcacctgat c                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
atctatacat tccaccgcgg                                                   20


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
gtaaatggcc atggccacc                                                    19


