                         SEQUENCE LISTING

<110>  Galapagos NV
 
<120>  MATURE ADAMTS6 POLYPEPTIDE, ITS PREPARATION AND METHODS OF USE

<130>  GAL-236-WO-PCT

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  1117
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp 
        275                 280                 285             


Ser Ser Leu Gly Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val 
    290                 295                 300                 


Leu Thr Glu Asp Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys 
305                 310                 315                 320 


Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln 
                325                 330                 335     


Ser Asp Gly Asn Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn 
            340                 345                 350         


Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro 
        355                 360                 365             


Cys Gly Thr Leu Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu 
    370                 375                 380                 


Arg Ser Cys Ser Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile 
                405                 410                 415     


Gly Asn Ser Cys Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala 
            420                 425                 430         


Ala His Ile Thr Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu 
    450                 455                 460                 


Asp Asn Glu Pro Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro 
465                 470                 475                 480 


Gly Gln Val Tyr Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala 
                485                 490                 495     


Thr Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys 
            500                 505                 510         


Leu Ser Lys Ser Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu 
        515                 520                 525             


Gly Thr Leu Cys Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln 
    530                 535                 540                 


Gly Asp Cys Val Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly 
545                 550                 555                 560 


Trp Gly Pro Trp Ser Leu Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
                565                 570                 575     


Gly Val Ser Ser Ser Leu Arg His Cys Asp Ser Pro Ala Pro Ser Gly 
            580                 585                 590         


Gly Gly Lys Tyr Cys Leu Gly Glu Arg Lys Arg Tyr Arg Ser Cys Asn 
        595                 600                 605             


Thr Asp Pro Cys Pro Leu Gly Ser Arg Asp Phe Arg Glu Lys Gln Cys 
    610                 615                 620                 


Ala Asp Phe Asp Asn Met Pro Phe Arg Gly Lys Tyr Tyr Asn Trp Lys 
625                 630                 635                 640 


Pro Tyr Thr Gly Gly Gly Val Lys Pro Cys Ala Leu Asn Cys Leu Ala 
                645                 650                 655     


Glu Gly Tyr Asn Phe Tyr Thr Glu Arg Ala Pro Ala Val Ile Asp Gly 
            660                 665                 670         


Thr Gln Cys Asn Ala Asp Ser Leu Asp Ile Cys Ile Asn Gly Glu Cys 
        675                 680                 685             


Lys His Val Gly Cys Asp Asn Ile Leu Gly Ser Asp Ala Arg Glu Asp 
    690                 695                 700                 


Arg Cys Arg Val Cys Gly Gly Asp Gly Ser Thr Cys Asp Ala Ile Glu 
705                 710                 715                 720 


Gly Phe Phe Asn Asp Ser Leu Pro Arg Gly Gly Tyr Met Glu Val Val 
                725                 730                 735     


Gln Ile Pro Arg Gly Ser Val His Ile Glu Val Arg Glu Val Ala Met 
            740                 745                 750         


Ser Lys Asn Tyr Ile Ala Leu Lys Ser Glu Gly Asp Asp Tyr Tyr Ile 
        755                 760                 765             


Asn Gly Ala Trp Thr Ile Asp Trp Pro Arg Lys Phe Asp Val Ala Gly 
    770                 775                 780                 


Thr Ala Phe His Tyr Lys Arg Pro Thr Asp Glu Pro Glu Ser Leu Glu 
785                 790                 795                 800 


Ala Leu Gly Pro Thr Ser Glu Asn Leu Ile Val Met Val Leu Leu Gln 
                805                 810                 815     


Glu Gln Asn Leu Gly Ile Arg Tyr Lys Phe Asn Val Pro Ile Thr Arg 
            820                 825                 830         


Thr Gly Ser Gly Asp Asn Glu Val Gly Phe Thr Trp Asn His Gln Pro 
        835                 840                 845             


Trp Ser Glu Cys Ser Ala Thr Cys Ala Gly Gly Val Gln Arg Gln Glu 
    850                 855                 860                 


Val Val Cys Lys Arg Leu Asp Asp Asn Ser Ile Val Gln Asn Asn Tyr 
865                 870                 875                 880 


Cys Asp Pro Asp Ser Lys Pro Pro Glu Asn Gln Arg Ala Cys Asn Thr 
                885                 890                 895     


Glu Pro Cys Pro Pro Glu Trp Phe Ile Gly Asp Trp Leu Glu Cys Ser 
            900                 905                 910         


Lys Thr Cys Asp Gly Gly Met Arg Thr Arg Ala Val Leu Cys Ile Arg 
        915                 920                 925             


Lys Ile Gly Pro Ser Glu Glu Glu Thr Leu Asp Tyr Ser Gly Cys Leu 
    930                 935                 940                 


Thr His Arg Pro Val Glu Lys Glu Pro Cys Asn Asn Gln Ser Cys Pro 
945                 950                 955                 960 


Pro Gln Trp Val Ala Leu Asp Trp Ser Glu Cys Thr Pro Lys Cys Gly 
                965                 970                 975     


Pro Gly Phe Lys His Arg Ile Val Leu Cys Lys Ser Ser Asp Leu Ser 
            980                 985                 990         


Lys Thr Phe Pro Ala Ala Gln Cys  Pro Glu Glu Ser Lys  Pro Pro Val 
        995                 1000                 1005             


Arg Ile  Arg Cys Ser Leu Gly  Arg Cys Pro Pro Pro  Arg Trp Val 
    1010                 1015                 1020             


Thr Gly  Asp Trp Gly Gln Cys  Ser Ala Gln Cys Gly  Leu Gly Gln 
    1025                 1030                 1035             


Gln Met  Arg Thr Val Gln Cys  Leu Ser Tyr Thr Gly  Gln Ala Ser 
    1040                 1045                 1050             


Ser Asp  Cys Leu Glu Thr Val  Arg Pro Pro Ser Met  Gln Gln Cys 
    1055                 1060                 1065             


Glu Ser  Lys Cys Asp Ser Thr  Pro Ile Ser Asn Thr  Glu Glu Cys 
    1070                 1075                 1080             


Lys Asp  Val Asn Lys Val Ala  Tyr Cys Pro Leu Val  Leu Lys Phe 
    1085                 1090                 1095             


Lys Phe  Cys Ser Arg Ala Tyr  Phe Arg Gln Met Cys  Cys Lys Thr 
    1100                 1105                 1110             


Cys Gln  Gly His 
    1115         


<210>  2
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp 
        275                 280                 285             


Ser Ser Leu Gly Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val 
    290                 295                 300                 


Leu Thr Glu Asp Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys 
305                 310                 315                 320 


Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln 
                325                 330                 335     


Ser Asp Gly Asn Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn 
            340                 345                 350         


Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro 
        355                 360                 365             


Cys Gly Thr Leu Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu 
    370                 375                 380                 


Arg Ser Cys Ser Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile 
                405                 410                 415     


Gly Asn Ser Cys Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala 
            420                 425                 430         


Ala His Ile Thr Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu 
    450                 455                 460                 


Asp Asn Glu Pro Pro Lys 
465                 470 


<210>  3
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp 
        275                 280                 285             


Ser Ser Leu Gly Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val 
    290                 295                 300                 


Leu Thr Glu Asp Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys 
305                 310                 315                 320 


Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln 
                325                 330                 335     


Ser Asp Gly Asn Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn 
            340                 345                 350         


Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro 
        355                 360                 365             


Cys Gly Thr Leu Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu 
    370                 375                 380                 


Arg Ser Cys Ser Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile 
                405                 410                 415     


Gly Asn Ser Cys Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala 
            420                 425                 430         


Ala His Ile Thr Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu 
    450                 455                 460                 


Asp Asn Glu Pro Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro 
465                 470                 475                 480 


Gly Gln Val Tyr Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala 
                485                 490                 495     


Thr Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys 
            500                 505                 510         


Leu Ser Lys Ser Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu 
        515                 520                 525             


Gly Thr Leu Cys Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln 
    530                 535                 540                 


Gly Asp Cys Val Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly 
545                 550                 555                 560 


<210>  4
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp 
        275                 280                 285             


Ser Ser Leu Gly Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val 
    290                 295                 300                 


Leu Thr Glu Asp Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys 
305                 310                 315                 320 


Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln 
                325                 330                 335     


Ser Asp Gly Asn Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn 
            340                 345                 350         


Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro 
        355                 360                 365             


Cys Gly Thr Leu Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu 
    370                 375                 380                 


Arg Ser Cys Ser Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile 
                405                 410                 415     


Gly Asn Ser Cys Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala 
            420                 425                 430         


Ala His Ile Thr Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu 
    450                 455                 460                 


Asp Asn Glu Pro Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro 
465                 470                 475                 480 


Gly Gln Val Tyr Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala 
                485                 490                 495     


Thr Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys 
            500                 505                 510         


Leu Ser Lys Ser Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu 
        515                 520                 525             


Gly Thr Leu Cys Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln 
    530                 535                 540                 


Gly Asp Cys Val Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly 
545                 550                 555                 560 


Trp Gly Pro Trp Ser Leu Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
                565                 570                 575     


Gly Val Ser Ser Ser Leu Arg His Cys Asp Ser Pro Ala Pro Ser Gly 
            580                 585                 590         


Gly Gly Lys Tyr Cys Leu Gly Glu Arg Lys Arg Tyr Arg Ser Cys Asn 
        595                 600                 605             


Thr Asp Pro Cys Pro 
    610             


<210>  5
<211>  718
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp 
        275                 280                 285             


Ser Ser Leu Gly Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val 
    290                 295                 300                 


Leu Thr Glu Asp Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys 
305                 310                 315                 320 


Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln 
                325                 330                 335     


Ser Asp Gly Asn Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn 
            340                 345                 350         


Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro 
        355                 360                 365             


Cys Gly Thr Leu Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu 
    370                 375                 380                 


Arg Ser Cys Ser Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile 
                405                 410                 415     


Gly Asn Ser Cys Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala 
            420                 425                 430         


Ala His Ile Thr Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu 
    450                 455                 460                 


Asp Asn Glu Pro Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro 
465                 470                 475                 480 


Gly Gln Val Tyr Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala 
                485                 490                 495     


Thr Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys 
            500                 505                 510         


Leu Ser Lys Ser Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu 
        515                 520                 525             


Gly Thr Leu Cys Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln 
    530                 535                 540                 


Gly Asp Cys Val Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly 
545                 550                 555                 560 


Trp Gly Pro Trp Ser Leu Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
                565                 570                 575     


Gly Val Ser Ser Ser Leu Arg His Cys Asp Ser Pro Ala Pro Ser Gly 
            580                 585                 590         


Gly Gly Lys Tyr Cys Leu Gly Glu Arg Lys Arg Tyr Arg Ser Cys Asn 
        595                 600                 605             


Thr Asp Pro Cys Pro Leu Gly Ser Arg Asp Phe Arg Glu Lys Gln Cys 
    610                 615                 620                 


Ala Asp Phe Asp Asn Met Pro Phe Arg Gly Lys Tyr Tyr Asn Trp Lys 
625                 630                 635                 640 


Pro Tyr Thr Gly Gly Gly Val Lys Pro Cys Ala Leu Asn Cys Leu Ala 
                645                 650                 655     


Glu Gly Tyr Asn Phe Tyr Thr Glu Arg Ala Pro Ala Val Ile Asp Gly 
            660                 665                 670         


Thr Gln Cys Asn Ala Asp Ser Leu Asp Ile Cys Ile Asn Gly Glu Cys 
        675                 680                 685             


Lys His Val Gly Cys Asp Asn Ile Leu Gly Ser Asp Ala Arg Glu Asp 
    690                 695                 700                 


Arg Cys Arg Val Cys Gly Gly Asp Gly Ser Thr Cys Asp Ala 
705                 710                 715             


<210>  6
<211>  843
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp 
        275                 280                 285             


Ser Ser Leu Gly Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val 
    290                 295                 300                 


Leu Thr Glu Asp Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys 
305                 310                 315                 320 


Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln 
                325                 330                 335     


Ser Asp Gly Asn Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn 
            340                 345                 350         


Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro 
        355                 360                 365             


Cys Gly Thr Leu Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu 
    370                 375                 380                 


Arg Ser Cys Ser Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile 
                405                 410                 415     


Gly Asn Ser Cys Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala 
            420                 425                 430         


Ala His Ile Thr Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu 
    450                 455                 460                 


Asp Asn Glu Pro Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro 
465                 470                 475                 480 


Gly Gln Val Tyr Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala 
                485                 490                 495     


Thr Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys 
            500                 505                 510         


Leu Ser Lys Ser Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu 
        515                 520                 525             


Gly Thr Leu Cys Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln 
    530                 535                 540                 


Gly Asp Cys Val Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly 
545                 550                 555                 560 


Trp Gly Pro Trp Ser Leu Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
                565                 570                 575     


Gly Val Ser Ser Ser Leu Arg His Cys Asp Ser Pro Ala Pro Ser Gly 
            580                 585                 590         


Gly Gly Lys Tyr Cys Leu Gly Glu Arg Lys Arg Tyr Arg Ser Cys Asn 
        595                 600                 605             


Thr Asp Pro Cys Pro Leu Gly Ser Arg Asp Phe Arg Glu Lys Gln Cys 
    610                 615                 620                 


Ala Asp Phe Asp Asn Met Pro Phe Arg Gly Lys Tyr Tyr Asn Trp Lys 
625                 630                 635                 640 


Pro Tyr Thr Gly Gly Gly Val Lys Pro Cys Ala Leu Asn Cys Leu Ala 
                645                 650                 655     


Glu Gly Tyr Asn Phe Tyr Thr Glu Arg Ala Pro Ala Val Ile Asp Gly 
            660                 665                 670         


Thr Gln Cys Asn Ala Asp Ser Leu Asp Ile Cys Ile Asn Gly Glu Cys 
        675                 680                 685             


Lys His Val Gly Cys Asp Asn Ile Leu Gly Ser Asp Ala Arg Glu Asp 
    690                 695                 700                 


Arg Cys Arg Val Cys Gly Gly Asp Gly Ser Thr Cys Asp Ala Ile Glu 
705                 710                 715                 720 


Gly Phe Phe Asn Asp Ser Leu Pro Arg Gly Gly Tyr Met Glu Val Val 
                725                 730                 735     


Gln Ile Pro Arg Gly Ser Val His Ile Glu Val Arg Glu Val Ala Met 
            740                 745                 750         


Ser Lys Asn Tyr Ile Ala Leu Lys Ser Glu Gly Asp Asp Tyr Tyr Ile 
        755                 760                 765             


Asn Gly Ala Trp Thr Ile Asp Trp Pro Arg Lys Phe Asp Val Ala Gly 
    770                 775                 780                 


Thr Ala Phe His Tyr Lys Arg Pro Thr Asp Glu Pro Glu Ser Leu Glu 
785                 790                 795                 800 


Ala Leu Gly Pro Thr Ser Glu Asn Leu Ile Val Met Val Leu Leu Gln 
                805                 810                 815     


Glu Gln Asn Leu Gly Ile Arg Tyr Lys Phe Asn Val Pro Ile Thr Arg 
            820                 825                 830         


Thr Gly Ser Gly Asp Asn Glu Val Gly Phe Thr 
        835                 840             


<210>  7
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val Val Ala Asp Lys 
1               5                   10                  15      


Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu His Tyr Ile Leu 
            20                  25                  30          


Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp Ser Ser Leu Gly 
        35                  40                  45              


Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val Leu Thr Glu Asp 
    50                  55                  60                  


Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys Ser Leu Asp Ser 
65                  70                  75                  80  


Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln Ser Asp Gly Asn 
                85                  90                  95      


Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn Ala Val Leu Ile 
            100                 105                 110         


Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro Cys Gly Thr Leu 
        115                 120                 125             


Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu Arg Ser Cys Ser 
    130                 135                 140                 


Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr Ile Ala His Glu 
145                 150                 155                 160 


Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile Gly Asn Ser Cys 
                165                 170                 175     


Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala Ala His Ile Thr 
            180                 185                 190         


Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser Arg Asp Tyr Ile 
        195                 200                 205             


Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu Asp Asn Glu Pro 
    210                 215                 220                 


Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro Gly Gln Val Tyr 
225                 230                 235                 240 


Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala Thr Ser Arg Gln 
                245                 250                 255     


Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys Leu Ser Lys Ser 
            260                 265                 270         


Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu Gly Thr Leu Cys 
        275                 280                 285             


Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln Gly Asp Cys Val 
    290                 295                 300                 


Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly Trp Gly Pro Trp 
305                 310                 315                 320 


Ser Leu Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Ser 
                325                 330                 335     


Ser Leu Arg His Cys Asp Ser Pro Ala Pro Ser Gly Gly Gly Lys Tyr 
            340                 345                 350         


Cys Leu Gly Glu Arg Lys Arg Tyr Arg Ser Cys Asn Thr Asp Pro Cys 
        355                 360                 365             


Pro Leu Gly Ser Arg Asp Phe Arg Glu Lys Gln Cys Ala Asp Phe Asp 
    370                 375                 380                 


Asn Met Pro Phe Arg Gly Lys Tyr Tyr Asn Trp Lys Pro Tyr Thr Gly 
385                 390                 395                 400 


Gly Gly Val Lys Pro Cys Ala Leu Asn Cys Leu Ala Glu Gly Tyr Asn 
                405                 410                 415     


Phe Tyr Thr Glu Arg Ala Pro Ala Val Ile Asp Gly Thr Gln Cys Asn 
            420                 425                 430         


Ala Asp Ser Leu Asp Ile Cys Ile Asn Gly Glu Cys Lys His Val Gly 
        435                 440                 445             


Cys Asp Asn Ile Leu Gly Ser Asp Ala Arg Glu Asp Arg Cys Arg Val 
    450                 455                 460                 


Cys Gly Gly Asp Gly Ser Thr Cys Asp Ala Ile Glu Gly Phe Phe Asn 
465                 470                 475                 480 


Asp Ser Leu Pro Arg Gly Gly Tyr Met Glu Val Val Gln Ile Pro Arg 
                485                 490                 495     


Gly Ser Val His Ile Glu Val Arg Glu Val Ala Met Ser Lys Asn Tyr 
            500                 505                 510         


Ile Ala Leu Lys Ser Glu Gly Asp Asp Tyr Tyr Ile Asn Gly Ala Trp 
        515                 520                 525             


Thr Ile Asp Trp Pro Arg Lys Phe Asp Val Ala Gly Thr Ala Phe His 
    530                 535                 540                 


Tyr Lys Arg Pro Thr Asp Glu Pro Glu Ser Leu Glu Ala Leu Gly Pro 
545                 550                 555                 560 


Thr Ser Glu Asn Leu Ile Val Met Val Leu Leu Gln Glu Gln Asn Leu 
                565                 570                 575     


Gly Ile Arg Tyr Lys Phe Asn Val Pro Ile Thr Arg Thr Gly Ser Gly 
            580                 585                 590         


Asp Asn Glu Val Gly Phe Thr 
        595                 


<210>  8
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Histidine tag sequence

<400>  8

Glu Asn Leu Tyr Phe Gln Gly Gly Gly Gly Gly Ser Leu Val Pro Arg 
1               5                   10                  15      


Gly Ser His His His His His His 
            20                  


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  9

Gly Gly Gly Gly Gly Ser 
1               5       


<210>  10
<211>  867
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Non-mature ADAMTS6 sequence with His tag

<400>  10

Met Glu Ile Leu Trp Lys Thr Leu Thr Trp Ile Leu Ser Leu Ile Met 
1               5                   10                  15      


Ala Ser Ser Glu Phe His Ser Asp His Arg Leu Ser Tyr Ser Ser Gln 
            20                  25                  30          


Glu Glu Phe Leu Thr Tyr Leu Glu His Tyr Gln Leu Thr Ile Pro Ile 
        35                  40                  45              


Arg Val Asp Gln Asn Gly Ala Phe Leu Ser Phe Thr Val Lys Asn Asp 
    50                  55                  60                  


Lys His Ser Arg Arg Arg Arg Ser Met Asp Pro Ile Asp Pro Gln Gln 
65                  70                  75                  80  


Ala Val Ser Lys Leu Phe Phe Lys Leu Ser Ala Tyr Gly Lys His Phe 
                85                  90                  95      


His Leu Asn Leu Thr Leu Asn Thr Asp Phe Val Ser Lys His Phe Thr 
            100                 105                 110         


Val Glu Tyr Trp Gly Lys Asp Gly Pro Gln Trp Lys His Asp Phe Leu 
        115                 120                 125             


Asp Asn Cys His Tyr Thr Gly Tyr Leu Gln Asp Gln Arg Ser Thr Thr 
    130                 135                 140                 


Lys Val Ala Leu Ser Asn Cys Val Gly Leu His Gly Val Ile Ala Thr 
145                 150                 155                 160 


Glu Asp Glu Glu Tyr Phe Ile Glu Pro Leu Lys Asn Thr Thr Glu Asp 
                165                 170                 175     


Ser Lys His Phe Ser Tyr Glu Asn Gly His Pro His Val Ile Tyr Lys 
            180                 185                 190         


Lys Ser Ala Leu Gln Gln Arg His Leu Tyr Asp His Ser His Cys Gly 
        195                 200                 205             


Val Ser Asp Phe Thr Arg Ser Gly Lys Pro Trp Trp Leu Asn Asp Thr 
    210                 215                 220                 


Ser Thr Val Ser Tyr Ser Leu Pro Ile Asn Asn Thr His Ile His His 
225                 230                 235                 240 


Arg Gln Lys Arg Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val 
                245                 250                 255     


Val Ala Asp Lys Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu 
            260                 265                 270         


His Tyr Ile Leu Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp 
        275                 280                 285             


Ser Ser Leu Gly Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val 
    290                 295                 300                 


Leu Thr Glu Asp Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys 
305                 310                 315                 320 


Ser Leu Asp Ser Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln 
                325                 330                 335     


Ser Asp Gly Asn Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn 
            340                 345                 350         


Ala Val Leu Ile Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro 
        355                 360                 365             


Cys Gly Thr Leu Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu 
    370                 375                 380                 


Arg Ser Cys Ser Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr 
385                 390                 395                 400 


Ile Ala His Glu Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile 
                405                 410                 415     


Gly Asn Ser Cys Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala 
            420                 425                 430         


Ala His Ile Thr Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser 
        435                 440                 445             


Arg Asp Tyr Ile Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu 
    450                 455                 460                 


Asp Asn Glu Pro Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro 
465                 470                 475                 480 


Gly Gln Val Tyr Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala 
                485                 490                 495     


Thr Ser Arg Gln Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys 
            500                 505                 510         


Leu Ser Lys Ser Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu 
        515                 520                 525             


Gly Thr Leu Cys Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln 
    530                 535                 540                 


Gly Asp Cys Val Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly 
545                 550                 555                 560 


Trp Gly Pro Trp Ser Leu Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly 
                565                 570                 575     


Gly Val Ser Ser Ser Leu Arg His Cys Asp Ser Pro Ala Pro Ser Gly 
            580                 585                 590         


Gly Gly Lys Tyr Cys Leu Gly Glu Arg Lys Arg Tyr Arg Ser Cys Asn 
        595                 600                 605             


Thr Asp Pro Cys Pro Leu Gly Ser Arg Asp Phe Arg Glu Lys Gln Cys 
    610                 615                 620                 


Ala Asp Phe Asp Asn Met Pro Phe Arg Gly Lys Tyr Tyr Asn Trp Lys 
625                 630                 635                 640 


Pro Tyr Thr Gly Gly Gly Val Lys Pro Cys Ala Leu Asn Cys Leu Ala 
                645                 650                 655     


Glu Gly Tyr Asn Phe Tyr Thr Glu Arg Ala Pro Ala Val Ile Asp Gly 
            660                 665                 670         


Thr Gln Cys Asn Ala Asp Ser Leu Asp Ile Cys Ile Asn Gly Glu Cys 
        675                 680                 685             


Lys His Val Gly Cys Asp Asn Ile Leu Gly Ser Asp Ala Arg Glu Asp 
    690                 695                 700                 


Arg Cys Arg Val Cys Gly Gly Asp Gly Ser Thr Cys Asp Ala Ile Glu 
705                 710                 715                 720 


Gly Phe Phe Asn Asp Ser Leu Pro Arg Gly Gly Tyr Met Glu Val Val 
                725                 730                 735     


Gln Ile Pro Arg Gly Ser Val His Ile Glu Val Arg Glu Val Ala Met 
            740                 745                 750         


Ser Lys Asn Tyr Ile Ala Leu Lys Ser Glu Gly Asp Asp Tyr Tyr Ile 
        755                 760                 765             


Asn Gly Ala Trp Thr Ile Asp Trp Pro Arg Lys Phe Asp Val Ala Gly 
    770                 775                 780                 


Thr Ala Phe His Tyr Lys Arg Pro Thr Asp Glu Pro Glu Ser Leu Glu 
785                 790                 795                 800 


Ala Leu Gly Pro Thr Ser Glu Asn Leu Ile Val Met Val Leu Leu Gln 
                805                 810                 815     


Glu Gln Asn Leu Gly Ile Arg Tyr Lys Phe Asn Val Pro Ile Thr Arg 
            820                 825                 830         


Thr Gly Ser Gly Asp Asn Glu Val Gly Phe Thr Glu Asn Leu Tyr Phe 
        835                 840                 845             


Gln Gly Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser His His His 
    850                 855                 860                 


His His His 
865         


<210>  11
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature ADAMTS6 sequence with His tag

<400>  11

Ser Val Ser Ile Glu Arg Phe Val Glu Thr Leu Val Val Ala Asp Lys 
1               5                   10                  15      


Met Met Val Gly Tyr His Gly Arg Lys Asp Ile Glu His Tyr Ile Leu 
            20                  25                  30          


Ser Val Met Asn Ile Val Ala Lys Leu Tyr Arg Asp Ser Ser Leu Gly 
        35                  40                  45              


Asn Val Val Asn Ile Ile Val Ala Arg Leu Ile Val Leu Thr Glu Asp 
    50                  55                  60                  


Gln Pro Asn Leu Glu Ile Asn His His Ala Asp Lys Ser Leu Asp Ser 
65                  70                  75                  80  


Phe Cys Lys Trp Gln Lys Ser Ile Leu Ser His Gln Ser Asp Gly Asn 
                85                  90                  95      


Thr Ile Pro Glu Asn Gly Ile Ala His His Asp Asn Ala Val Leu Ile 
            100                 105                 110         


Thr Arg Tyr Asp Ile Cys Thr Tyr Lys Asn Lys Pro Cys Gly Thr Leu 
        115                 120                 125             


Gly Leu Ala Ser Val Ala Gly Met Cys Glu Pro Glu Arg Ser Cys Ser 
    130                 135                 140                 


Ile Asn Glu Asp Ile Gly Leu Gly Ser Ala Phe Thr Ile Ala His Glu 
145                 150                 155                 160 


Ile Gly His Asn Phe Gly Met Asn His Asp Gly Ile Gly Asn Ser Cys 
                165                 170                 175     


Gly Thr Lys Gly His Glu Ala Ala Lys Leu Met Ala Ala His Ile Thr 
            180                 185                 190         


Ala Asn Thr Asn Pro Phe Ser Trp Ser Ala Cys Ser Arg Asp Tyr Ile 
        195                 200                 205             


Thr Ser Phe Leu Asp Ser Gly Arg Gly Thr Cys Leu Asp Asn Glu Pro 
    210                 215                 220                 


Pro Lys Arg Asp Phe Leu Tyr Pro Ala Val Ala Pro Gly Gln Val Tyr 
225                 230                 235                 240 


Asp Ala Asp Glu Gln Cys Arg Phe Gln Tyr Gly Ala Thr Ser Arg Gln 
                245                 250                 255     


Cys Lys Tyr Gly Glu Val Cys Arg Glu Leu Trp Cys Leu Ser Lys Ser 
            260                 265                 270         


Asn Arg Cys Val Thr Asn Ser Ile Pro Ala Ala Glu Gly Thr Leu Cys 
        275                 280                 285             


Gln Thr Gly Asn Ile Glu Lys Gly Trp Cys Tyr Gln Gly Asp Cys Val 
    290                 295                 300                 


Pro Phe Gly Thr Trp Pro Gln Ser Ile Asp Gly Gly Trp Gly Pro Trp 
305                 310                 315                 320 


Ser Leu Trp Gly Glu Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Ser 
                325                 330                 335     


Ser Leu Arg His Cys Asp Ser Pro Ala Pro Ser Gly Gly Gly Lys Tyr 
            340                 345                 350         


Cys Leu Gly Glu Arg Lys Arg Tyr Arg Ser Cys Asn Thr Asp Pro Cys 
        355                 360                 365             


Pro Leu Gly Ser Arg Asp Phe Arg Glu Lys Gln Cys Ala Asp Phe Asp 
    370                 375                 380                 


Asn Met Pro Phe Arg Gly Lys Tyr Tyr Asn Trp Lys Pro Tyr Thr Gly 
385                 390                 395                 400 


Gly Gly Val Lys Pro Cys Ala Leu Asn Cys Leu Ala Glu Gly Tyr Asn 
                405                 410                 415     


Phe Tyr Thr Glu Arg Ala Pro Ala Val Ile Asp Gly Thr Gln Cys Asn 
            420                 425                 430         


Ala Asp Ser Leu Asp Ile Cys Ile Asn Gly Glu Cys Lys His Val Gly 
        435                 440                 445             


Cys Asp Asn Ile Leu Gly Ser Asp Ala Arg Glu Asp Arg Cys Arg Val 
    450                 455                 460                 


Cys Gly Gly Asp Gly Ser Thr Cys Asp Ala Ile Glu Gly Phe Phe Asn 
465                 470                 475                 480 


Asp Ser Leu Pro Arg Gly Gly Tyr Met Glu Val Val Gln Ile Pro Arg 
                485                 490                 495     


Gly Ser Val His Ile Glu Val Arg Glu Val Ala Met Ser Lys Asn Tyr 
            500                 505                 510         


Ile Ala Leu Lys Ser Glu Gly Asp Asp Tyr Tyr Ile Asn Gly Ala Trp 
        515                 520                 525             


Thr Ile Asp Trp Pro Arg Lys Phe Asp Val Ala Gly Thr Ala Phe His 
    530                 535                 540                 


Tyr Lys Arg Pro Thr Asp Glu Pro Glu Ser Leu Glu Ala Leu Gly Pro 
545                 550                 555                 560 


Thr Ser Glu Asn Leu Ile Val Met Val Leu Leu Gln Glu Gln Asn Leu 
                565                 570                 575     


Gly Ile Arg Tyr Lys Phe Asn Val Pro Ile Thr Arg Thr Gly Ser Gly 
            580                 585                 590         


Asp Asn Glu Val Gly Phe Thr Glu Asn Leu Tyr Phe Gln Gly Gly Gly 
        595                 600                 605             


Gly Gly Ser Leu Val Pro Arg Gly Ser His His His His His His 
    610                 615                 620             


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate XII


<220>
<221>  substrat12_pos7
<222>  (7)..(7)
<223>  Nva

<400>  12

Arg Pro Lys Pro Tyr Ala Xaa Trp Met Lys 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate XIV


<220>
<221>  substrate14_pos1
<222>  (1)..(1)
<223>  Abu

<220>
<221>  substrate14_pos3
<222>  (3)..(3)
<223>  Cha

<220>
<221>  substrate14_pos4
<222>  (4)..(4)
<223>  Abu

<220>
<221>  substrate14_pos5
<222>  (5)..(5)
<223>  Smc

<220>
<221>  substrate14_pos8
<222>  (8)..(8)
<223>  Dab

<400>  13

Xaa Pro Xaa Xaa Xaa His Ala Xaa Ala Lys 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate XII with Q and F


<220>
<221>  substrate12_QF_pos1
<222>  (1)..(1)
<223>  modified with a Fluorophore group

<220>
<221>  substrate12_QF_pos7
<222>  (7)..(7)
<223>  Nva

<220>
<221>  substrate12_QF_pos10
<222>  (10)..(10)
<223>  modified with a Quencher group

<400>  14

Arg Pro Lys Pro Tyr Ala Xaa Trp Met Lys 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Substrate XIV with Q and F


<220>
<221>  substrate14_QF_pos1
<222>  (1)..(1)
<223>  Abu modified with a Quencher group

<220>
<221>  substrate14_QF_pos3
<222>  (3)..(3)
<223>  Cha

<220>
<221>  substrate14_QF_pos4
<222>  (4)..(4)
<223>  Abu

<220>
<221>  substrate14_QF_pos5
<222>  (5)..(5)
<223>  Smc

<220>
<221>  substrate14_QF_pos8
<222>  (8)..(8)
<223>  Dab modified with a Quencher group

<400>  15

Xaa Pro Xaa Xaa Xaa His Ala Xaa Ala Lys 
1               5                   10  


<210>  16
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide1_pos1
<222>  (1)..(1)
<223>  5-FAM-E

<220>
<221>  peptide1_pos12
<222>  (12)..(12)
<223>  K(5-TAMRA)

<400>  17

Glu Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Lys Lys Lys 
1               5                   10                  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide2_pos1
<222>  (1)..(1)
<223>  5-FAM-E

<220>
<221>  peptide2_pos10
<222>  (10)..(10)
<223>  K(QXL520)-NH2

<400>  18

Glu Lys Pro Ala Lys Phe Phe Arg Leu Lys 
1               5                   10  


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide3_pos1
<222>  (1)..(1)
<223>  5-FAM-L

<220>
<221>  peptide3_pos11
<222>  (11)..(11)
<223>  K-(5-TAMRA)-NH2

<400>  19

Leu Ala Gln Ala Val Arg Ser Ser Ser Arg Lys 
1               5                   10      


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide4_pos1
<222>  (1)..(1)
<223>  5-FAM-E

<220>
<221>  peptide4_pos14
<222>  (14)..(14)
<223>  K(5-TAMRA)-NH2

<400>  20

Glu Arg Leu Ala Gln Ala Gln Gln Gln Leu Pro Lys Lys Lys 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide5_pos1
<222>  (1)..(1)
<223>  5-FAM-E

<220>
<221>  peptide5_pos14
<222>  (14)..(14)
<223>  K(5-TAMRA)-NH2

<400>  21

Glu Arg Pro Ala Gln Ala Gln Gln Gln Leu Pro Lys Lys Lys 
1               5                   10                  


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide6_pos1
<222>  (1)..(1)
<223>  5-FAM-L

<220>
<221>  peptide6_pos12
<222>  (12)..(12)
<223>  K(5-TAMRA)-NH2

<400>  22

Leu Ala Gln Ala Gln Gln Gln Leu Pro Lys Lys Lys 
1               5                   10          


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide7_pos1
<222>  (1)..(1)
<223>  5-FAM-E

<220>
<221>  peptide7_pos13
<222>  (13)..(13)
<223>  K(5-TAMRA)-NH2

<400>  23

Glu Arg Phe Ala Gln Ala Gln Gln Gln Leu Lys Lys Lys 
1               5                   10              


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide8_pos1
<222>  (1)..(1)
<223>  5-FAM-L

<220>
<221>  peptide8_pos11
<222>  (11)..(11)
<223>  K(5-TAMRA)-NH2

<400>  24

Leu Ala Asn Ala Val Arg Ser Ser Ser Arg Lys 
1               5                   10      


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide9_pos1
<222>  (1)..(1)
<223>  5-FAM-R

<220>
<221>  peptide9_pos9
<222>  (9)..(9)
<223>  K(5-TAMRA)-NH2

<400>  25

Arg Pro Pro Gly Phe Ser Ala Phe Lys 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide10_pos1
<222>  (1)..(1)
<223>  5-FAM-P

<220>
<221>  peptide10_pos7
<222>  (7)..(7)
<223>  K(5-TAMRA)

<400>  26

Pro Leu Gly Leu Ala Arg Lys Lys Lys 
1               5                   


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide11_pos1
<222>  (1)..(1)
<223>  5 FAM-T

<220>
<221>  peptide11_pos12
<222>  (12)..(12)
<223>  L(5-TAMRA)-NH2

<400>  27

Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Leu 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide12_pos1
<222>  (1)..(1)
<223>  5(6)-Fluorescein-A

<220>
<221>  peptide12_pos12
<222>  (12)..(12)
<223>  K-[5(6)-TAMRA]-NH2

<400>  28

Ala Glu Leu Gln Gly Arg Pro Ile Ser Ile Ala Lys 
1               5                   10          


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide13_pos1
<222>  (1)..(1)
<223>  5-FAM-S

<220>
<221>  peptide13_pos11
<222>  (11)..(11)
<223>  K(TAMRA)-NH2

<400>  29

Ser His Leu Gly Leu Ala Arg Ser Asn Leu Lys 
1               5                   10      


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide14_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-D

<220>
<221>  peptide14_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  30

Asp Val Ala Asn Tyr Asn Phe Phe Lys 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide15_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-P

<220>
<221>  peptide15_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  31

Pro Leu Cys Ser Ala Val Leu Ile Lys 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide16_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-T

<220>
<221>  peptide16_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  32

Thr Ile Gly Gly Gly Met Ser Gly Lys 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide17_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-N

<220>
<221>  peptide17_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  33

Asn Lys Pro Arg Arg Pro Tyr Ile Lys 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide18_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-R

<220>
<221>  peptide18_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  34

Arg Arg Val Arg Ala Asn Asp Arg Lys 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  pepetide19_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-Y

<220>
<221>  pepetide19_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  35

Tyr Leu Gln Ala Ser Thr Gly Tyr Lys 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide20_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-D

<220>
<221>  peptide20_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  36

Asp Val Lys Val Ser Leu Phe Lys Lys 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide21_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-R

<220>
<221>  peptide21_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  37

Arg Pro Pro Gly Phe Ser Pro Phe Lys 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide22_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-S

<220>
<221>  peptide22_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  38

Ser Pro Leu Leu Thr Gln Glu Thr Lys 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide23_pos1
<222>  (1)..(1)
<223>  5-amino-2-nitrobenzoyl-T

<220>
<221>  peptide23_pos9
<222>  (9)..(9)
<223>  K(Mca)-NH2

<400>  39

Thr Ser Glu Asp Leu Val Val Gln Lys 
1               5                   


<210>  40
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  peptide24_pos1
<222>  (1)..(1)
<223>  acetyl-PEG4-Q

<220>
<221>  peptide24_pos3
<222>  (3)..(3)
<223>  K(QSY21)

<220>
<221>  peptide24_pos15
<222>  (15)..(15)
<223>  C(Chromis 645 A-PDA)-amide

<400>  40

Gln Arg Lys Val Arg Met Ala His Ile Val Phe Ser Phe Pro Cys 
1               5                   10                  15  


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  substrate1_pos1
<222>  (1)..(1)
<223>  Mca

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  substrate1_pos6
<222>  (6)..(6)
<223>  Dpa

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Xaa Pro Xaa Gly Xaa His Ala Xaa 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  substrate4_pos1
<222>  (1)..(1)
<223>  Mca

<220>
<221>  substrate4_pos3
<222>  (3)..(3)
<223>  Cha

<220>
<221>  substrate4_pos5
<222>  (5)..(5)
<223>  Nva

<220>
<221>  substrate4_pos8
<222>  (8)..(8)
<223>  Dpa

<400>  42

Xaa Pro Xaa Gly Xaa His Ala Xaa 
1               5               


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  substrate5_pos1
<222>  (1)..(1)
<223>  NBD-R, where NBD is quencher

<220>
<221>  substrate5_pos7
<222>  (7)..(7)
<223>  Nva

<220>
<221>  substrate5_pos9
<222>  (9)..(9)
<223>  K(DMC)-NH2, wherein DMC is a fluorophore

<400>  43

Arg Pro Lys Pro Leu Ala Xaa Trp Lys 
1               5                   


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  substrate12_pos1
<222>  (1)..(1)
<223>  5-FAM-R

<220>
<221>  substrate12_pos7
<222>  (7)..(7)
<223>  Nva

<220>
<221>  substrate12_pos10
<222>  (10)..(10)
<223>  K(QXL-520)-NH2

<400>  44

Arg Pro Lys Pro Tyr Ala Xaa Trp Met Lys 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  substrate14_pos1
<222>  (1)..(1)
<223>  (QXL-520)-gamma-Abu

<220>
<221>  substrate14_pos3
<222>  (3)..(3)
<223>  Cha

<220>
<221>  substrate14_pos4
<222>  (4)..(4)
<223>  Abu

<220>
<221>  substrate14_pos5
<222>  (5)..(5)
<223>  Smc

<220>
<221>  substrate14_pos8
<222>  (8)..(8)
<223>  Dab(5-FAM)

<400>  45

Xaa Pro Xaa Xaa Xaa His Ala Xaa Ala Lys 
1               5                   10  


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  substrate15_pos1
<222>  (1)..(1)
<223>  (QXL-520)-gamma-Abu

<220>
<221>  substrate15_pos6
<222>  (6)..(6)
<223>  Dab(5-FAM)

<400>  46

Xaa Pro Gln Gly Leu Xaa Ala Lys 
1               5               


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  substrate3_pos1
<222>  (1)..(1)
<223>  Mca (= 7 - Methoxycoumarin - 4 - acetic acid)

<220>
<221>  substrate3_pos8
<222>  (8)..(8)
<223>  Dpa

<400>  47

Xaa Pro Leu Ala Gln Ala Val Xaa Arg Ser Ser Ser Arg 
1               5                   10              


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  fluoro_substrate5_pos1
<222>  (1)..(1)
<223>  Mca

<220>
<221>  fluoro_substrate5_pos10
<222>  (10)..(10)
<223>  K(Dnp)-OH

<400>  48

Xaa Arg Pro Pro Gly Phe Ser Ala Phe Lys 
1               5                   10  


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  fluoro_MMP_substrate_pos1
<222>  (1)..(1)
<223>  Dnp

<220>
<221>  fluoro_MMP_substrate_pos3
<222>  (3)..(3)
<223>  b-cyclohexyl-A

<220>
<221>  fluoro_MMP_substrate_pos5
<222>  (5)..(5)
<223>  Cys(Me)

<220>
<221>  fluoro_MMP_substrate_pos8
<222>  (8)..(8)
<223>  K(Nma)

<400>  49

Xaa Pro Ala Gly Cys His Ala Lys 
1               5               


<210>  50
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  aggrecanase_substrate_pos1
<222>  (1)..(1)
<223>  Abz

<220>
<221>  aggrecanase_substrate_pos12
<222>  (12)..(12)
<223>  Dap(Dnp)

<400>  50

Xaa Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Xaa Lys Lys 
1               5                   10                  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  TACE_substrate1_pos1
<222>  (1)..(1)
<223>  DABCYL-L

<220>
<221>  TACE_substrate1_pos10
<222>  (10)..(10)
<223>  R-EDANS

<400>  51

Leu Ala Gln Ala Val Arg Ser Ser Ser Arg 
1               5                   10  


<210>  52
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  VWF73_pos5
<222>  (5)..(5)
<223>  Dap(Nma)

<220>
<221>  VWF73_pos16
<222>  (16)..(16)
<223>  Dap(Dnp)

<220>
<221>  VWF73_pos74
<222>  (74)..(74)
<223>  R-OH

<400>  52

His Asp Arg Glu Xaa Ala Pro Asn Leu Val Tyr Met Val Thr Gly Xaa 
1               5                   10                  15      


Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly Asp Ile Gln Val Val 
            20                  25                  30          


Pro Ile Gly Val Gly Pro Asn Ala Asn Val Gln Glu Leu Glu Arg Ile 
        35                  40                  45              


Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp Phe Glu Thr Leu Pro 
    50                  55                  60                  


Arg Glu Ala Pro Asp Leu Val Leu Asn Arg 
65                  70                  


