                         SEQUENCE LISTING

<110>  Amgen, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING AN ARTICULAR DISORDER

<130>  32512/50288 PC

<150>  US 62/345,533
<151>  2016-06-03

<160>  154   

<170>  PatentIn version 3.5

<210>  1
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu or Met

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ala or Pro

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Ile or Val

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa is Ala, Val, or Thr

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa is Asn or Thr

<220>
<221>  MISC_FEATURE
<222>  (45)..(52)
<223>  Linker

<400>  1

Cys Xaa Xaa Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Glu Trp Val Cys Asp Gly Xaa Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Xaa Xaa Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  2
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  CII-M05

<400>  2

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  3
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  CII-M13

<400>  3

Cys Met Ala Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Val Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  4
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  CII-M18

<400>  4

Cys Met Ala Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Val Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  5
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  CII-M26

<400>  5

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Glu Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Thr Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  6
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II M01

<400>  6

Cys Gln Ser Gly Gln Phe Gln Cys Ser Asn Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Gln Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Lys Gly Cys Gly Asp Ser His Ile Leu Pro Phe Ser Ala Pro Gly 
        35                  40                  45              


Pro Ser Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
    50                  55                  60      


<210>  7
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II M02

<400>  7

Cys Gln Ser Ser Gln Phe Lys Cys Gln Asn Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Asn Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        35                  40                  45              


Pro Ser Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
    50                  55                  60      


<210>  8
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II M03

<400>  8

Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu Cys Ile His Ile 
1               5                   10                  15      


Ser Trp Arg Cys Asp Val Trp Glu Asp Cys Lys Asp Gly Trp Asp Trp 
            20                  25                  30          


Asp Gln Cys Pro Thr Lys Arg Pro Glu Glu Val Ser Leu Gln Lys Ala 
        35                  40                  45              


Ser Gly Ala Leu Glu 
    50              


<210>  9
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II M04

<400>  9

Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu Cys Ile His Ser 
1               5                   10                  15      


Ser Trp Arg Cys Asp Phe Ile Glu Asp Cys Lys Asp Gly Trp Asp Trp 
            20                  25                  30          


Pro Trp Cys Pro Thr Lys Arg Pro Glu Glu Val Ser Leu Gln Lys Ala 
        35                  40                  45              


Ser Gly Ala Leu Glu 
    50              


<210>  10
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II M05a

<400>  10

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Arg Arg Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  11
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD01

<400>  11

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Asn Cys Gly Asp Ser His Ile Leu Pro Phe Ser Ala Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Arg Ser Gly Glu Phe Pro Cys Glu Asn Gly Gln Cys 
    50                  55                  60                  


Leu Ser Arg Arg Leu Gly Cys Asp Gly Asp Asn Asp Cys Ala Asp Ser 
65                  70                  75                  80  


Ser Asp Glu Thr Gly Cys Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala 
                85                  90                  95      


Pro Ala Ala Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
            100                 105                 


<210>  12
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD02

<400>  12

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Cys Leu Ala Gly Gln Phe 
        35                  40                  45              


Gln Cys Lys Ser Asn Asp Lys Cys Val Pro Pro Gln Trp Val Cys Asp 
    50                  55                  60                  


Gly Val Asn Asp Cys Leu Asp Asn Ser Asp Glu Ala Asn Cys Lys Thr 
65                  70                  75                  80  


Ala Val Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90                  


<210>  13
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD03

<400>  13

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Asn Cys Gly Asp Ser His Ile Leu Pro Phe Ser Ala Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Arg Pro Asn Gln Phe Gln Cys His Gly Thr Asp Thr 
    50                  55                  60                  


Cys Leu Pro Arg Pro Leu Ala Cys Gly Gly Val Asn Asp Cys Gly Asp 
65                  70                  75                  80  


Ser Ser Asp Glu Pro Leu Glu Asn Cys Thr Thr Pro Glu Pro Thr Ser 
                85                  90                  95      


Leu Gln Lys Ala Ser Gly Ala Leu Glu 
            100                 105 


<210>  14
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD04

<400>  14

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Gln Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Arg Gly Cys Gly Asp Ser His Ile Pro Pro Phe Ser Ala Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Leu Ser Asn Gln Phe Thr Cys His Asp Asn Asn Thr 
    50                  55                  60                  


Cys Leu Ser Gln Ala Leu Val Cys Asp Gly Val Asn Asp Cys Glu Asp 
65                  70                  75                  80  


Asp Ser Asp Glu Lys Ser Cys Ser Ala Pro Ala Ser Glu Pro Pro Gly 
                85                  90                  95      


Ser Leu Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
            100                 105             


<210>  15
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD05

<400>  15

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Gln Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Lys Gly Cys Gly Asp Ser His Ile Leu Pro Phe Ser Ala Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Leu Gly Gly Glu Phe Thr Cys Asp Asn Gly Asn Cys 
    50                  55                  60                  


Leu Pro Ala Ser Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Asn 
65                  70                  75                  80  


Ser Asp Glu Thr Gly Cys Lys Thr Ser Ala Arg Thr Ser Leu Gln Lys 
                85                  90                  95      


Ala Ser Gly Ala Leu Glu 
            100         


<210>  16
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD06

<400>  16

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Gln Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Lys Gly Cys Gly Asp Ser His Ile Leu Pro Phe Ser Ala Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Gln Ala Asn Gln Phe Pro Cys Arg Gly Gly Asn Cys 
    50                  55                  60                  


Val Pro Gln Thr Leu Arg Cys Asp Gly Asp Pro Asp Cys Leu Asp Gly 
65                  70                  75                  80  


Ser Asp Glu Glu Ser Cys Gln Pro Arg Thr Ser Leu Gln Lys Ala Ser 
                85                  90                  95      


Gly Ala Leu Glu 
            100 


<210>  17
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD07

<400>  17

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Gln Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Lys Gly Cys Gly Asp Ser His Ile Leu Pro Phe Ser Ala Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Asp Ser Pro Gly Gln Phe Lys Cys Gly Ser Gly Arg 
    50                  55                  60                  


Cys Val Pro Gln Thr Leu Leu Cys Asp Gly Asp Asn Asp Cys Glu Asp 
65                  70                  75                  80  


Asp Ser Asp Glu Lys Asp Cys Glu Gln His Thr Ser Leu Gln Lys Ala 
                85                  90                  95      


Ser Gly Ala Leu Glu 
            100     


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD08

<400>  18

Cys Gln Ser Gly Gln Phe Lys Cys Gln Asn Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Asn Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Gln Ser Asn Glu Phe Pro Cys Ser Asn Gly Ser Cys 
    50                  55                  60                  


Val Pro Val Thr Leu Val Cys Asp Gly Glu Asp Asp Cys Glu Asp Gly 
65                  70                  75                  80  


Ser Asp Glu Ser Pro Ala Thr Cys Gly Asp Ser His Ile Leu Leu Phe 
                85                  90                  95      


Ser Thr Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu 
            100                 105                 110         


Glu 
    


<210>  19
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD09

<400>  19

Cys Gln Ser Ser Gln Phe Lys Cys Gln Asn Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Asn Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Pro Ser Gly Gln Phe Pro Cys Glu Asn Gly Arg Cys 
    50                  55                  60                  


Leu Pro Pro Gly Leu Ala Cys Gly Gly Val Asn Asp Cys Val Asp Asp 
65                  70                  75                  80  


Ser Asp Glu Thr Ser Cys Gly Ser Ala Ala His Thr Ser Leu Gln Lys 
                85                  90                  95      


Ala Ser Gly Ala Leu Glu 
            100         


<210>  20
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD1

<400>  20

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Cys Ala Ala Asn Gln Phe 
        35                  40                  45              


Thr Cys His Asn Ser Gly Arg Cys Ile Pro Arg Ala Leu Leu Cys Asp 
    50                  55                  60                  


Gly Glu Asp Asp Cys Ala Asp Gly Ser Asp Glu Ser Glu Leu Cys Ala 
65                  70                  75                  80  


Thr Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90              


<210>  21
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD11

<400>  21

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Gln Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Lys Gly Cys Gly Asp Ser His Ile Leu Pro Phe Ser Ala Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Leu Gly Gly Glu Phe Thr Cys Asp Asn Gly Asn Cys 
    50                  55                  60                  


Leu Pro Ala Ser Trp Val Cys Asp Gly Val Asn Asp Cys Leu Asp Asn 
65                  70                  75                  80  


Ser Asp Glu Ala Asn Cys Lys Thr Ala Val Arg Thr Ser Leu Gln Lys 
                85                  90                  95      


Ala Ser Gly Ala Leu Glu 
            100         


<210>  22
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD12

<400>  22

Cys Leu Ala Asn Gln Phe Lys Cys Gln Asn Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Asn Cys Gly Asp Ser His Ile Leu Pro Phe Ser Ala Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Pro Ser Gly Gln Phe Arg Cys Gly Ser Gly Gln Cys 
    50                  55                  60                  


Leu Pro Glu His Trp Pro Cys Asp Gly Val Asn Asp Cys Leu Asp Asn 
65                  70                  75                  80  


Ser Asp Glu Ala Asn Cys Lys Thr Ala Val Arg Thr Ser Leu Gln Lys 
                85                  90                  95      


Ala Ser Gly Ala Leu Glu 
            100         


<210>  23
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD12

<400>  23

Cys Pro Ser Asp Gln Phe Pro Cys Arg Ser Thr Ser Thr Cys Val Pro 
1               5                   10                  15      


Arg Ala Leu Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Asn Ser Asp 
            20                  25                  30          


Glu Glu Gly Cys Glu Lys His Thr Cys Gln Ser Ser Gln Phe Lys Cys 
        35                  40                  45              


Gln Asn Ser Arg Thr Cys Leu Leu Pro Gly Trp Val Cys Asp Gly Val 
    50                  55                  60                  


Asp Asp Cys Pro Asp Gly Ser Asp Glu Thr Asn Cys Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Pro Ser Ser Thr Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala 
                85                  90                  95      


Ser Gly Ala Leu Glu 
            100     


<210>  24
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD14

<400>  24

Cys Pro Pro Asp Gln Phe Gln Cys Asn Asn Gly His Cys Ile Pro Gly 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Asn Ser Asp Glu 
            20                  25                  30          


Glu Gly Cys Glu Lys His Thr Cys Gln Ser Ser Gln Phe Lys Cys Gln 
        35                  40                  45              


Asn Ser Arg Thr Cys Leu Leu Pro Gly Trp Val Cys Asp Gly Val Asp 
    50                  55                  60                  


Asp Cys Pro Asp Gly Ser Asp Glu Thr Asn Cys Gly Asp Ser His Ile 
65                  70                  75                  80  


Leu Pro Ser Ser Thr Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala Ser 
                85                  90                  95      


Gly Ala Leu Glu 
            100 


<210>  25
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD15

<400>  25

Cys Pro Pro Gly Glu Phe Pro Cys Asn Ser Asp Lys Arg Cys Val Pro 
1               5                   10                  15      


Gln Ser Trp Val Cys Asp Gly Glu Asp Asp Cys Gln Asp Ser Ser Asp 
            20                  25                  30          


Glu Glu Asn Cys Ala Pro His Thr Cys Gln Ser Ser Gln Phe Lys Cys 
        35                  40                  45              


Gln Asn Ser Arg Thr Cys Leu Leu Pro Gly Trp Val Cys Asp Gly Val 
    50                  55                  60                  


Asp Asp Cys Pro Asp Gly Ser Asp Glu Thr Asn Cys Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala 
                85                  90                  95      


Ser Gly Ala Leu Glu 
            100     


<210>  26
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD16

<400>  26

Cys Ala Pro Asp Glu Phe Gln Cys Asn Asn Gly His Cys Leu Pro Pro 
1               5                   10                  15      


Gly Leu Gly Cys Asp Gly Asp Asp Asp Cys Pro Asp Ser Ser Asp Glu 
            20                  25                  30          


Thr Gly Cys Thr Pro His Thr Cys Gln Ser Ser Gln Phe Lys Cys Gln 
        35                  40                  45              


Asn Ser Arg Thr Cys Leu Leu Pro Gly Trp Val Cys Asp Gly Val Asp 
    50                  55                  60                  


Asp Cys Pro Asp Gly Ser Asp Glu Thr Asn Cys Gly Asp Ser His Ile 
65                  70                  75                  80  


Leu Pro Ser Ser Thr Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala Ser 
                85                  90                  95      


Gly Ala Leu Glu 
            100 


<210>  27
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD17

<400>  27

Cys Pro Pro Gly Glu Phe Pro Cys Asn Ser Asp Lys Arg Cys Val Pro 
1               5                   10                  15      


Gln Ser Trp Val Cys Asp Gly Glu Asp Asp Cys Gln Asp Ser Ser Asp 
            20                  25                  30          


Glu Glu Gly Cys Glu Pro His Thr Cys Gln Ser Ser Gln Phe Lys Cys 
        35                  40                  45              


Gln Asn Ser Arg Thr Cys Leu Leu Pro Gly Trp Val Cys Asp Gly Val 
    50                  55                  60                  


Asp Asp Cys Pro Asp Gly Ser Asp Glu Thr Asn Cys Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala 
                85                  90                  95      


Ser Gly Ala Leu Glu 
            100     


<210>  28
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD18

<400>  28

Cys Gly Ala Asn Gln Phe Thr Cys Asp Asn Gly Arg Cys Val Pro Glu 
1               5                   10                  15      


Pro Leu Arg Cys Asp Gly Glu Asp Asp Cys Gly Asp Asn Ser Asp Glu 
            20                  25                  30          


Ala Ser Cys Ala Glu His Thr Cys Gln Ser Ser Gln Phe Lys Cys Gln 
        35                  40                  45              


Asn Ser Arg Thr Cys Leu Leu Pro Gly Trp Val Cys Asp Gly Val Asp 
    50                  55                  60                  


Asp Cys Pro Asp Gly Ser Asp Glu Thr Asn Cys Gly Asp Ser His Ile 
65                  70                  75                  80  


Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala Ser 
                85                  90                  95      


Gly Ala Leu Glu 
            100 


<210>  29
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD19

<400>  29

Cys Gln Pro Gly Glu Phe Pro Cys Asn Ser Asp Lys Arg Cys Val Pro 
1               5                   10                  15      


Gln Ser Trp Val Cys Asp Gly Glu Asp Asp Cys Gln Asp Ser Ser Asp 
            20                  25                  30          


Glu Glu Asn Cys Ala Pro His Thr Cys Gln Ser Ser Gln Phe Lys Cys 
        35                  40                  45              


Gln Asn Ser Arg Thr Cys Leu Leu Pro Gly Trp Val Cys Asp Gly Val 
    50                  55                  60                  


Asp Asp Cys Pro Asp Gly Ser Asp Glu Thr Asn Cys Gly Asp Ser His 
65                  70                  75                  80  


Ile Leu Pro Phe Ser Thr Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala 
                85                  90                  95      


Ser Gly Ala Leu Glu 
            100     


<210>  30
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD20

<400>  30

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Arg Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Cys Ala Ala Asn Gln Phe 
        35                  40                  45              


Thr Cys His Asn Ser Gly Arg Cys Ile Pro Arg Ala Leu Leu Cys Asp 
    50                  55                  60                  


Gly Glu Asp Asp Cys Ala Asp Gly Ser Asp Glu Ser Glu Leu Cys Ala 
65                  70                  75                  80  


Thr Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90              


<210>  31
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD21

<400>  31

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Asn Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Ala Pro Asn Gln Phe Pro Cys Lys Ser Gly His Cys 
    50                  55                  60                  


Leu Pro Pro His Leu Gly Cys Asp Gly Asp Pro Asp Cys Glu Asp Gly 
65                  70                  75                  80  


Ser Asp Glu Ser Leu Ala Leu Cys Thr Thr Ser Val His Thr Ser Leu 
                85                  90                  95      


Gln Lys Ala Ser Gly Ala Leu Glu 
            100                 


<210>  32
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD22

<400>  32

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Leu Ala Asn Cys Pro Thr Pro Thr Cys Ala Pro Gly Glu Phe 
        35                  40                  45              


Lys Cys Arg Asn Gly Arg Cys Ile Pro Ala Asp Trp Val Cys Asp Gly 
    50                  55                  60                  


Glu Asn Asp Cys Leu Asp Asn Ser Asp Glu Ala Asn Cys Lys Thr Ala 
65                  70                  75                  80  


Val Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90              


<210>  33
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  anti-Collagen II WD23

<400>  33

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Asn Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Pro Ala Gly Gln Phe Arg Cys Lys Asn Gly Gln Cys 
    50                  55                  60                  


Val Pro Ala His Leu Arg Cys Asp Gly Glu Asn Asp Cys Glu Asp Gly 
65                  70                  75                  80  


Ser Asp Glu Lys Asn Cys Arg Thr Thr Gly Pro Thr Ser Leu Gln Lys 
                85                  90                  95      


Ala Ser Gly Ala Leu Glu 
            100         


<210>  34
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  M06

<400>  34

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Gln Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ala Asp Cys Ala Thr Pro Ala His Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  35
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  M07

<400>  35

Cys Leu Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ala Asp Cys Ala Thr Pro Ala His Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  36
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  M08

<400>  36

Cys Gln Ser Ser Gln Phe Lys Cys Gln Asn Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Gly Asp Ser His Ile Leu Leu Phe Ser Thr 
        35                  40                  45              


Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
    50                  55                  60              


<210>  37
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M01

<400>  37

Cys Gln Ser Gly Gln Phe Lys Cys Gln Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ala Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  38
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M02

<400>  38

Cys Met Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ala Pro Thr Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  39
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M03

<400>  39

Cys Leu Gly Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  40
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M04

<400>  40

Cys Met Pro Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ala Pro Thr Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  41
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M05

<400>  41

Cys Met Ala Gly Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  42
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M06

<400>  42

Cys Met Ala Gly Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  43
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M07

<400>  43

Cys Met Gly Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ala Pro Thr Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  44
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M08

<400>  44

Cys Met Pro Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Met Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Ser Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  45
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M09

<400>  45

Cys Met Gly Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  46
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M10

<400>  46

Cys Met Ala Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  47
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M11

<400>  47

Cys Met Pro Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ala Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  48
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M12

<400>  48

Cys Met Ala Gly Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Met Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  49
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M13

<400>  49

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  50
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M14

<400>  50

Cys Met Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Leu Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Leu Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  51
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M15

<400>  51

Cys Asn Pro Gly Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Ile Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        35                  40                  45              


Pro Ser Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
    50                  55                  60      


<210>  52
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M16

<400>  52

Cys Met Pro Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Met Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser His Leu Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  53
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M17

<400>  53

Cys Met Ala Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Leu Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  54
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M18

<400>  54

Cys Met Ser Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Ile Glu Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Arg Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  55
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M19

<400>  55

Cys Met Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Ile Glu Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  56
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M20

<400>  56

Cys Gln Gly Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  57
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M21

<400>  57

Cys Met Gly Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asp Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  58
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M22

<400>  58

Cys Met Glu Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Val Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  59
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M23

<400>  59

Cys Met Ala Gly Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Gln Ser Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ala Pro Thr Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  60
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M24

<400>  60

Cys Met Pro Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Val Glu Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Glu Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  61
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M25

<400>  61

Cys Met Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  62
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M26

<400>  62

Cys Met Gly Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Thr Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Leu Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  63
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M27

<400>  63

Cys Met Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Met Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  64
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M28

<400>  64

Cys Met Ala Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  65
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M29

<400>  65

Cys Met Ala Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ala Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  66
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M30

<400>  66

Cys Met Ala Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Arg Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  67
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM01

<400>  67

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Glu Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Gln Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  68
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM02

<400>  68

Cys Met Pro Asn Gln Phe Lys Cys Lys Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  69
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM03

<400>  69

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Glu Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  70
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM04

<400>  70

Cys Met Ser Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Ile Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  71
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM05

<400>  71

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Thr Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  72
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM06

<400>  72

Cys Met Ser Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Glu Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  73
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM07

<400>  73

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Gln Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  74
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM08

<400>  74

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ala Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Val Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  75
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM09

<400>  75

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  76
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM10

<400>  76

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Asp Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  77
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM11

<400>  77

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Thr Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  78
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM12

<400>  78

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Pro Pro Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  79
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM13

<400>  79

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Glu Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Leu Pro Ser Val Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  80
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM14

<400>  80

Cys Met Pro Asn Gln Phe Lys Cys Lys Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ser Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  81
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM15

<400>  81

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Ile Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  82
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM16

<400>  82

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Glu Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  83
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM17

<400>  83

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ser Trp Val Cys Asp Gly Ile Glu Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  84
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM18

<400>  84

Cys Met Ala Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Val Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  85
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM19

<400>  85

Cys Met Pro Asn Gln Phe Lys Cys Ser Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  86
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM20

<400>  86

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ala Pro Thr Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  87
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM21

<400>  87

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Glu Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Gly Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  88
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM22

<400>  88

Cys Met Pro Thr Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ser Ile Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  89
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM23

<400>  89

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Ala Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  90
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM24

<400>  90

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Ser Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  91
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM25

<400>  91

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Met Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ser Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  92
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM26

<400>  92

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Glu Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Thr Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  93
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM27

<400>  93

Cys Met Pro Asn Gln Phe Lys Cys Lys Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  94
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2683mutM28

<400>  94

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Asp Thr Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  95
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Coll2mutM13

<400>  95

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        35                  40                  45              


Gly Ala Leu Glu 
    50          


<210>  96
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M01

<400>  96

Cys Ala Pro Asp Gln Phe Gln Cys Gly Asn Gly Gln Cys Val Pro Leu 
1               5                   10                  15      


Glu Trp Arg Cys Asp Gly Val Asn Asp Cys Glu Asp Gly Ser Asp Glu 
            20                  25                  30          


Glu Asp Cys Ala Thr Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu 
        35                  40                  45              


Glu 
    


<210>  97
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M04

<400>  97

Cys His Pro Thr Thr Gln Phe Glu Cys Asn Ser Gly Arg Cys Ile Pro 
1               5                   10                  15      


Ala Thr Trp Val Cys Asp Gly Glu Asp Asp Cys Glu Asp Gly Ser Asp 
            20                  25                  30          


Glu Pro Pro Ala Leu Cys Ala Gly Pro Glu His Thr Ser Leu Gln Lys 
        35                  40                  45              


Ala Ser Gly Ala Leu Glu 
    50                  


<210>  98
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M08

<400>  98

Cys Leu Ala Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Ser Leu Arg Cys Asp Gly Val Asp Asp Cys Arg Asp Asn Ser Asp Glu 
            20                  25                  30          


Ser Pro Ala His Cys Ala Lys Arg Thr Ser Leu Gln Lys Ala Ser Gly 
        35                  40                  45              


Ala Leu Glu 
    50      


<210>  99
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M09

<400>  99

Cys Leu Ala Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Ser Leu Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Asp Ser Asp Glu 
            20                  25                  30          


Ala Pro Asp His Cys Glu Ala Arg Thr Ser Leu Gln Lys Ala Ser Gly 
        35                  40                  45              


Ala Leu Glu 
    50      


<210>  100
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M16

<400>  100

Cys Leu Ala Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Ser Leu Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Asn Ser Asp Glu 
            20                  25                  30          


Ala Leu Ala His Cys Gln Pro Arg Thr Ser Leu Gln Lys Ala Ser Gly 
        35                  40                  45              


Ala Leu Glu 
    50      


<210>  101
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M17

<400>  101

Cys Leu Ala Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Glu Trp Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Ala Pro Ala His Cys Glu Ala Arg Thr Ser Leu Gln Lys Ala Ser Gly 
        35                  40                  45              


Ala Leu Glu 
    50      


<210>  102
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M18

<400>  102

Cys Leu Ala Ser Glu Phe Pro Cys Asp Asn Gly Arg Cys Ile Pro Leu 
1               5                   10                  15      


Ala Trp Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Ser Ser Asp Glu 
            20                  25                  30          


Ser Pro Ala His Cys Glu Ala Arg Thr Ser Leu Gln Lys Ala Ser Gly 
        35                  40                  45              


Ala Leu Glu 
    50      


<210>  103
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M21

<400>  103

Cys Leu Ser Asn Gln Phe Gln Cys His Gly Thr Lys Ile Cys Val Pro 
1               5                   10                  15      


Val Glu Trp Val Cys Asp Gly Asp Asn Asp Cys Gly Asp Asp Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Leu Cys Gly Arg Leu Gly Pro Gly Ala Thr Ser Ala 
        35                  40                  45              


Pro Ala Ala Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
    50                  55                  60      


<210>  104
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M24

<400>  104

Cys Pro Ser Asp Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Arg Trp Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Ser Ser Asp Glu 
            20                  25                  30          


Ser Pro Ala His Cys Thr Lys Arg Thr Ser Leu Gln Lys Ala Ser Gly 
        35                  40                  45              


Ala Leu Glu 
    50      


<210>  105
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M27

<400>  105

Cys Arg Ala Asp Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Arg Leu Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Asn Ser Asp Glu 
            20                  25                  30          


Ala Leu Ala His Cys Ala Thr Pro Thr Ser Leu Gln Lys Ala Ser Gly 
        35                  40                  45              


Ala Leu Glu 
    50      


<210>  106
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M28

<400>  106

Cys Arg Pro Asp Glu Phe Pro Cys Asp Asn Gly Asn Cys Val Pro Leu 
1               5                   10                  15      


Arg Trp Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Ser Ser Asp Glu 
            20                  25                  30          


Ser Pro Ala His Cys Glu Ala Arg Thr Ser Leu Gln Lys Ala Ser Gly 
        35                  40                  45              


Ala Leu Glu 
    50      


<210>  107
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  IL1-R1 M30

<400>  107

Cys Gln Ala Ser Glu Phe Pro Cys Asn Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Gln Trp Arg Cys Asp Gly Val Asp Asp Cys Gly Asp Asn Ser Asp Glu 
            20                  25                  30          


Ala Ser Ala His Cys Lys Pro His Thr Ser Leu Gln Lys Ala Ser Gly 
        35                  40                  45              


Ala Leu Glu 
    50      


<210>  108
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  WD02

<400>  108

Cys Ala Pro Asn Gln Phe Gln Cys Arg Gly Ser Gly Thr Cys Ile Pro 
1               5                   10                  15      


Gln Arg Trp Leu Cys Asp Gly Glu Asp Asp Cys Ala Asp Gly Ser Asp 
            20                  25                  30          


Glu Pro Pro Glu Cys Thr Gly Ser Ala Tyr Thr Cys Leu Ala Ser Glu 
        35                  40                  45              


Phe Pro Cys Asp Asn Gly Arg Cys Ile Pro Leu Ala Trp Arg Cys Asp 
    50                  55                  60                  


Gly Val Asn Asp Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys 
65                  70                  75                  80  


Glu Ala Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90                  


<210>  109
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  WD08

<400>  109

Cys Leu Ala Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Glu Trp Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Ala Pro Ala His Cys Glu Ala Arg Thr Cys Gln Pro Asp Glu Phe Thr 
        35                  40                  45              


Cys Gly Ser Gly Gly Cys Leu Ser Leu His Trp Val Cys Asp Gly Val 
    50                  55                  60                  


Asn Asp Cys Val Asp Ser Ser Asp Glu Glu Asp Cys Glu Thr Pro Val 
65                  70                  75                  80  


His Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90          


<210>  110
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  WD16T

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  110

Cys Leu Ser Asn Gln Phe Pro Cys Xaa Gly Thr Lys Xaa Ala Phe Gln 
1               5                   10                  15      


Trp Ser Gly Phe Ala Thr Ala Met Met Ile Val Gly Thr Thr Arg Met 
            20                  25                  30          


Asn Arg Arg His Ser Val Ala Pro Trp Leu Gln Val Arg Leu Leu His 
        35                  40                  45              


Arg Arg Gly Ala Trp Pro Thr Ser Ala Arg Ala Thr Thr Ala Ala Ala 
    50                  55                  60                  


Ile His Thr Cys Val Ala Thr Thr Leu Met Ile Val Arg Thr Thr Arg 
65                  70                  75                  80  


Met Asn Cys Trp Leu Ala Val Leu Arg Val Arg His Cys Val Arg Pro 
                85                  90                  95      


Leu Gly Ser Ser Ser Thr Thr Thr Thr Thr Thr Thr Thr 
            100                 105                 


<210>  111
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  WD27

<400>  111

Cys Leu Ser Asn Gln Phe Gln Cys His Gly Thr Lys Ile Cys Val Pro 
1               5                   10                  15      


Val Glu Trp Val Cys Asp Gly Asp Asn Asp Cys Gly Asp Asp Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Leu Cys Gly Arg Leu Gly Pro Gly Ala Thr Ser Ala 
        35                  40                  45              


Pro Ala Ala Cys Arg Ala Asp Glu Phe Pro Cys Asp Asn Gly Arg Cys 
    50                  55                  60                  


Val Pro Leu Ser Leu Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Asp 
65                  70                  75                  80  


Ser Asp Glu Ala Pro Asp His Cys Glu Ala Arg Thr Ser Leu Gln Lys 
                85                  90                  95      


Ala Ser Gly Ala Leu Glu 
            100         


<210>  112
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  WD30

<400>  112

Cys Pro Pro Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Thr Cys Arg Pro Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  113
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  WD33tet

<400>  113

Cys Gln Ser Asp Glu Phe Arg Cys Ser Asn Thr Gly Arg Cys Val Pro 
1               5                   10                  15      


Gln Ser Trp Val Cys Asp Gly Glu Asp Asp Cys Arg Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Asp Cys Thr Thr Ala Val His Thr Cys Leu Ser Asn Gln Phe 
        35                  40                  45              


Gln Cys His Gly Thr Lys Ile Cys Val Pro Val Glu Trp Val Cys Asp 
    50                  55                  60                  


Gly Asp Asn Asp Cys Gly Asp Asp Ser Asp Glu Ser Pro Ala Leu Cys 
65                  70                  75                  80  


Gly Arg Leu Gly Pro Gly Ala Thr Ser Ala Pro Ala Ala Cys Leu Ala 
                85                  90                  95      


Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu Ser Leu Arg 
            100                 105                 110         


Cys Asp Gly Asp Asn Asp Cys Ala Asp Ser Ser Asp Glu Ala Gly Cys 
        115                 120                 125             


Gly Arg Pro Gly Pro Gly Ala Thr Ser Ala Pro Ala Ala Cys Leu Ala 
    130                 135                 140                 


Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Cys Asp Gly Val Asn Asp Cys Gly Asp Asn Ser Asp Glu Ala Leu Ala 
                165                 170                 175     


His Cys Gln Pro Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
            180                 185                 190         


<210>  114
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD05

<400>  114

Cys Pro Pro Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Arg Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Leu Thr Cys Arg Ala Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Ser Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ser His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  115
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD06

<400>  115

Cys Pro Pro Asn Glu Phe Lys Cys Ser Arg Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Leu Thr Cys Arg Ala Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Arg Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  116
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD07T

<400>  116

Cys Pro Leu Asn Glu Phe Arg Cys Asp Ser Gly Gln Cys Leu Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asn Cys Ser Asn Arg Thr Cys Arg Ser Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ala Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Cys Gln Pro Ala Glu Phe Thr Cys Gly Ser Gly Gly Cys Leu Ser Leu 
                85                  90                  95      


His Trp Val Cys Asp Gly Val Asn Asp Cys Val Asp Ser Ser Asp Glu 
            100                 105                 110         


Glu Asp Cys Glu Thr Pro Val His Thr Ser Leu Gln Lys Ala Ser Gly 
        115                 120                 125             


Ala Leu Glu 
    130     


<210>  117
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD11

<400>  117

Cys Pro Pro Asn Glu Phe Ser Cys Asn Ser Gly Lys Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asn Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Ser Cys Arg Ala Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Lys Cys Val Ala Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ser His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  118
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD12

<400>  118

Cys Pro Pro Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Thr Cys Arg Ala Asp Gln Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Glu Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Asn Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  119
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD14

<400>  119

Cys Pro Ala Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys Val Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Arg Cys Arg Ser Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asp Asp 
    50                  55                  60                  


Cys Gly Asp Arg Ser Asp Glu Ala Pro Glu His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  120
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD20

<400>  120

Cys Pro Pro Asn Met Phe Arg Cys Asn Ser Gly Lys Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr His Arg Thr Cys Arg Ala Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Lys Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  121
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD22

<400>  121

Cys Pro Pro Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Glu Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Ile His Cys Thr Glu Leu Thr Cys Arg Ala Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Lys Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  122
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD23

<400>  122

Cys Pro Pro Asn Glu Phe Arg Cys Ser Ser Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Thr Cys Arg Ala Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Leu Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Asn Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  123
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD27

<400>  123

Cys Pro Pro Asn Glu Phe Arg Cys Ser Asn Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Thr Cys Arg Ala Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Pro Leu Arg Thr Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  124
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD29

<400>  124

Cys Arg Thr Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Thr Cys Arg Ala Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Gly Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  125
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD34 clean

<400>  125

Cys Pro Pro Asn Glu Phe Arg Cys Asn Asn Gly Lys Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Thr Cys Arg Ala Ala Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Lys Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  126
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C2730mut_WD39

<400>  126

Cys Pro Pro Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Trp Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Ala Arg Thr Cys Arg Ala Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Ala Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
                85                  90  


<210>  127
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huIL-1R1 WD02-huColl2 mut M13

<400>  127

Cys Ala Pro Asn Gln Phe Gln Cys Arg Gly Ser Gly Thr Cys Ile Pro 
1               5                   10                  15      


Gln Arg Trp Leu Cys Asp Gly Glu Asp Asp Cys Ala Asp Gly Ser Asp 
            20                  25                  30          


Glu Pro Pro Glu Cys Thr Gly Ser Ala Tyr Thr Cys Leu Ala Ser Glu 
        35                  40                  45              


Phe Pro Cys Asp Asn Gly Arg Cys Ile Pro Leu Ala Trp Arg Cys Asp 
    50                  55                  60                  


Gly Val Asn Asp Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys 
65                  70                  75                  80  


Glu Ala Arg Thr Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg 
                85                  90                  95      


Thr Cys Leu Leu Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu 
        115                 120                 125             


Gln Lys Ala Ser Gly Ala Leu Glu 
    130                 135     


<210>  128
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M13-huIL-1R1 WD02

<400>  128

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Cys Ala Pro Asn Gln Phe 
        35                  40                  45              


Gln Cys Arg Gly Ser Gly Thr Cys Ile Pro Gln Arg Trp Leu Cys Asp 
    50                  55                  60                  


Gly Glu Asp Asp Cys Ala Asp Gly Ser Asp Glu Pro Pro Glu Cys Thr 
65                  70                  75                  80  


Gly Ser Ala Tyr Thr Cys Leu Ala Ser Glu Phe Pro Cys Asp Asn Gly 
                85                  90                  95      


Arg Cys Ile Pro Leu Ala Trp Arg Cys Asp Gly Val Asn Asp Cys Gly 
            100                 105                 110         


Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr Ser Leu 
        115                 120                 125             


Gln Lys Ala Ser Gly Ala Leu Glu 
    130                 135     


<210>  129
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huIL-1R1 WD08-huColl2 mut M13

<400>  129

Cys Leu Ala Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Glu Trp Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Ala Pro Ala His Cys Glu Ala Arg Thr Cys Gln Pro Asp Glu Phe Thr 
        35                  40                  45              


Cys Gly Ser Gly Gly Cys Leu Ser Leu His Trp Val Cys Asp Gly Val 
    50                  55                  60                  


Asn Asp Cys Val Asp Ser Ser Asp Glu Glu Asp Cys Glu Thr Pro Val 
65                  70                  75                  80  


His Thr Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys 
                85                  90                  95      


Leu Leu Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly 
            100                 105                 110         


Ser Asp Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys 
        115                 120                 125             


Ala Ser Gly Ala Leu Glu 
    130                 


<210>  130
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M13-huIL-1R1 WD08

<400>  130

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Cys Leu Ala Asn Glu Phe 
        35                  40                  45              


Pro Cys Asp Asn Gly Arg Cys Val Pro Leu Glu Trp Arg Cys Asp Gly 
    50                  55                  60                  


Val Asn Asp Cys Gly Asp Gly Ser Asp Glu Ala Pro Ala His Cys Glu 
65                  70                  75                  80  


Ala Arg Thr Cys Gln Pro Asp Glu Phe Thr Cys Gly Ser Gly Gly Cys 
                85                  90                  95      


Leu Ser Leu His Trp Val Cys Asp Gly Val Asn Asp Cys Val Asp Ser 
            100                 105                 110         


Ser Asp Glu Glu Asp Cys Glu Thr Pro Val His Thr Ser Leu Gln Lys 
        115                 120                 125             


Ala Ser Gly Ala Leu Glu 
    130                 


<210>  131
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huIL-1R1 WD30-huColl2 mut M13

<400>  131

Cys Pro Pro Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Thr Cys Arg Pro Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
                85                  90                  95      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            100                 105                 110         


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Ser Leu Gln Lys Ala Ser 
        115                 120                 125             


Gly Ala Leu Glu 
    130         


<210>  132
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M13-huIL-1R1 WD30

<400>  132

Cys Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Ser Pro Ala Asn Cys Pro Thr Pro Thr Cys Pro Pro Asn Glu Phe 
        35                  40                  45              


Arg Cys Asn Ser Gly Gln Cys Ile Pro Pro His Trp Leu Cys Asp Gly 
    50                  55                  60                  


Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu Thr Asp Cys Thr Glu Arg 
65                  70                  75                  80  


Thr Cys Arg Pro Asp Glu Phe Pro Cys Asp Asn Gly Asn Cys Val Pro 
                85                  90                  95      


Leu Arg Trp Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Ser Ser Asp 
            100                 105                 110         


Glu Ser Pro Ala His Cys Glu Ala Arg Thr Ser Leu Gln Lys Ala Ser 
        115                 120                 125             


Gly Ala Leu Glu 
    130         


<210>  133
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huIL-1R1 WD02-huColl2 mut M15

<400>  133

Cys Ala Pro Asn Gln Phe Gln Cys Arg Gly Ser Gly Thr Cys Ile Pro 
1               5                   10                  15      


Gln Arg Trp Leu Cys Asp Gly Glu Asp Asp Cys Ala Asp Gly Ser Asp 
            20                  25                  30          


Glu Pro Pro Glu Cys Thr Gly Ser Ala Tyr Thr Cys Leu Ala Ser Glu 
        35                  40                  45              


Phe Pro Cys Asp Asn Gly Arg Cys Ile Pro Leu Ala Trp Arg Cys Asp 
    50                  55                  60                  


Gly Val Asn Asp Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys 
65                  70                  75                  80  


Glu Ala Arg Thr Cys Asn Pro Gly Gln Phe Lys Cys Arg Ser Ser Arg 
                85                  90                  95      


Thr Cys Leu Leu Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro 
            100                 105                 110         


Asp Gly Ser Asp Glu Thr Ile Cys Gly Asp Ser His Ile Leu Pro Phe 
        115                 120                 125             


Ser Thr Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu 
    130                 135                 140                 


Glu 
145 


<210>  134
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M15-huIL-1R1 WD02

<400>  134

Cys Asn Pro Gly Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Ile Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Ala Pro Asn Gln Phe Gln Cys Arg Gly Ser Gly Thr 
    50                  55                  60                  


Cys Ile Pro Gln Arg Trp Leu Cys Asp Gly Glu Asp Asp Cys Ala Asp 
65                  70                  75                  80  


Gly Ser Asp Glu Pro Pro Glu Cys Thr Gly Ser Ala Tyr Thr Cys Leu 
                85                  90                  95      


Ala Ser Glu Phe Pro Cys Asp Asn Gly Arg Cys Ile Pro Leu Ala Trp 
            100                 105                 110         


Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Ser Ser Asp Glu Ser Pro 
        115                 120                 125             


Ala His Cys Glu Ala Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu 
    130                 135                 140                 


Glu 
145 


<210>  135
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huIL-1R1 WD08-huColl2 mut M15

<400>  135

Cys Leu Ala Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys Val Pro Leu 
1               5                   10                  15      


Glu Trp Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Ala Pro Ala His Cys Glu Ala Arg Thr Cys Gln Pro Asp Glu Phe Thr 
        35                  40                  45              


Cys Gly Ser Gly Gly Cys Leu Ser Leu His Trp Val Cys Asp Gly Val 
    50                  55                  60                  


Asn Asp Cys Val Asp Ser Ser Asp Glu Glu Asp Cys Glu Thr Pro Val 
65                  70                  75                  80  


His Thr Cys Asn Pro Gly Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys 
                85                  90                  95      


Leu Leu Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly 
            100                 105                 110         


Ser Asp Glu Thr Ile Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr 
        115                 120                 125             


Pro Gly Pro Ser Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
    130                 135                 140             


<210>  136
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M15-huIL-1R1 WD08

<400>  136

Cys Asn Pro Gly Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Ile Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Leu Ala Asn Glu Phe Pro Cys Asp Asn Gly Arg Cys 
    50                  55                  60                  


Val Pro Leu Glu Trp Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Gly 
65                  70                  75                  80  


Ser Asp Glu Ala Pro Ala His Cys Glu Ala Arg Thr Cys Gln Pro Asp 
                85                  90                  95      


Glu Phe Thr Cys Gly Ser Gly Gly Cys Leu Ser Leu His Trp Val Cys 
            100                 105                 110         


Asp Gly Val Asn Asp Cys Val Asp Ser Ser Asp Glu Glu Asp Cys Glu 
        115                 120                 125             


Thr Pro Val His Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
    130                 135                 140             


<210>  137
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huIL-1R1 WD30-huColl2 mut M15

<400>  137

Cys Pro Pro Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys Ile Pro Pro 
1               5                   10                  15      


His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser Asp Glu 
            20                  25                  30          


Thr Asp Cys Thr Glu Arg Thr Cys Arg Pro Asp Glu Phe Pro Cys Asp 
        35                  40                  45              


Asn Gly Asn Cys Val Pro Leu Arg Trp Arg Cys Asp Gly Val Asn Asp 
    50                  55                  60                  


Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu Ala Arg Thr 
65                  70                  75                  80  


Cys Asn Pro Gly Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
                85                  90                  95      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            100                 105                 110         


Glu Thr Ile Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        115                 120                 125             


Pro Ser Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
    130                 135                 140     


<210>  138
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  huColl2 mut M15-huIL-1R1 WD30

<400>  138

Cys Asn Pro Gly Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu 
1               5                   10                  15      


Pro Gly Trp Val Cys Asp Gly Val Asp Asp Cys Pro Asp Gly Ser Asp 
            20                  25                  30          


Glu Thr Ile Cys Gly Asp Ser His Ile Leu Pro Phe Ser Thr Pro Gly 
        35                  40                  45              


Pro Ser Thr Cys Pro Pro Asn Glu Phe Arg Cys Asn Ser Gly Gln Cys 
    50                  55                  60                  


Ile Pro Pro His Trp Leu Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly 
65                  70                  75                  80  


Ser Asp Glu Thr Asp Cys Thr Glu Arg Thr Cys Arg Pro Asp Glu Phe 
                85                  90                  95      


Pro Cys Asp Asn Gly Asn Cys Val Pro Leu Arg Trp Arg Cys Asp Gly 
            100                 105                 110         


Val Asn Asp Cys Gly Asp Ser Ser Asp Glu Ser Pro Ala His Cys Glu 
        115                 120                 125             


Ala Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
    130                 135                 140     


<210>  139
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  linker

<400>  139

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  140
<211>  177
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-1ra

<220>
<221>  SIGNAL
<222>  (1)..(25)

<400>  140

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  141
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  CII M26

<400>  141

Met Ala Gly Pro Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
1               5                   10                  15      


Leu Glu Ala Ser Gly Gly Ser Cys Met Pro Asn Gln Phe Lys Cys Arg 
            20                  25                  30          


Ser Ser Arg Thr Cys Leu Leu Pro Glu Trp Val Cys Asp Gly Ile Asp 
        35                  40                  45              


Asp Cys Pro Asp Gly Ser Asp Glu Ser Pro Thr Asn Cys Pro Thr Pro 
    50                  55                  60                  


Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu 
65                  70                  75  


<210>  142
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  CII M26

<400>  142
atggccggtc cggcctaccc gtatgatgtt ccggattatg ccccgggtct ggaggcgtct       60

ggtggttcgt gtatgccgaa ccagttcaag tgcaggtcgt cgaggacgtg cctcctaccg      120

gagtgggttt gcgacggcat tgatgattgt ccggacggat cggatgaatc gccgactaac      180

tgtccaacgc ctacgtcatt gcagaaggcc tctggggccc tcgag                      225


<210>  143
<211>  2415
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human aggrecan

<400>  143

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly His Val Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Pro Gly Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Ala Thr Thr Gly 
        595                 600                 605             


Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala Gly 
    610                 615                 620                 


Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg Pro 
625                 630                 635                 640 


Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr Pro 
                645                 650                 655     


Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe Cys 
            660                 665                 670         


Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly Gly 
        675                 680                 685             


Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln Val 
    690                 695                 700                 


Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala Val 
705                 710                 715                 720 


Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro Glu 
                725                 730                 735     


Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser Pro 
            740                 745                 750         


Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Glu Thr Glu 
        755                 760                 765             


Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser Glu 
    770                 775                 780                 


Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser Pro 
785                 790                 795                 800 


Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu Leu 
                805                 810                 815     


Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser Glu 
            820                 825                 830         


Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Glu Pro 
        835                 840                 845             


Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro Asp 
    850                 855                 860                 


Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu Asp 
865                 870                 875                 880 


Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser Gly 
                885                 890                 895     


Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu Thr 
            900                 905                 910         


Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp Pro 
        915                 920                 925             


Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu Glu 
    930                 935                 940                 


Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Glu 
945                 950                 955                 960 


Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro 
                965                 970                 975     


Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser 
            980                 985                 990         


Gly Leu Pro Ser Gly Glu Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu 
        995                 1000                 1005             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala 
    1010                 1015                 1020             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1025                 1030                 1035             


Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1040                 1045                 1050             


Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly Val Glu  Asp Ile Ser 
    1055                 1060                 1065             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1070                 1075                 1080             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1085                 1090                 1095             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1100                 1105                 1110             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1115                 1120                 1125             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1130                 1135                 1140             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1145                 1150                 1155             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1160                 1165                 1170             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1175                 1180                 1185             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1190                 1195                 1200             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1205                 1210                 1215             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1220                 1225                 1230             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1235                 1240                 1245             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1250                 1255                 1260             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1265                 1270                 1275             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu 
    1280                 1285                 1290             


Glu Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala 
    1295                 1300                 1305             


Pro Gly  Val Asp Glu Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1310                 1315                 1320             


Glu Thr  Thr Ala Pro Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser 
    1325                 1330                 1335             


Gly Glu  Val Leu Glu Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser 
    1340                 1345                 1350             


Gly Leu  Pro Ser Gly Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr 
    1370                 1375                 1380             


Ser Ala  Ser Gly Ile Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Gly Leu  Glu Thr Ser Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Glu Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly 
    1415                 1420                 1425             


Asp Leu  Ser Gly Val Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser 
    1430                 1435                 1440             


Ala Ser  Glu Val Gly Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg 
    1445                 1450                 1455             


Glu Gly  Leu Glu Thr Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly 
    1460                 1465                 1470             


Leu Pro  Ser Gly Lys Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp 
    1475                 1480                 1485             


Leu Asp  Leu Gly Lys Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln 
    1490                 1495                 1500             


Ala Pro  Glu Thr Ser Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr 
    1505                 1510                 1515             


Ser Gly  Val Asp Leu Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp 
    1520                 1525                 1530             


Phe Ser  Gly Leu Pro Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp 
    1535                 1540                 1545             


Ser Thr  Leu Val Glu Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu 
    1550                 1555                 1560             


Glu Gly  Arg Gly Thr Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser 
    1565                 1570                 1575             


Gly Leu  Pro Ser Ser Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly 
    1580                 1585                 1590             


Leu Pro  Ser Gly Thr Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro 
    1595                 1600                 1605             


Asp Val  Ser Gly Glu Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln 
    1610                 1615                 1620             


Pro Ser  Gly Phe Pro Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr 
    1625                 1630                 1635             


Glu Leu  Ser Gly Leu Ser Ser  Gly Gln Pro Gly Val  Ser Gly Glu 
    1640                 1645                 1650             


Ala Ser  Gly Val Leu Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr 
    1655                 1660                 1665             


Asp Leu  Ser Gly Glu Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln 
    1670                 1675                 1680             


Pro Ser  Gly Leu Pro Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro 
    1685                 1690                 1695             


Asp Leu  Val Ser Gly Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly 
    1700                 1705                 1710             


Ile Thr  Phe Val Asp Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr 
    1715                 1720                 1725             


Phe Lys  Glu Glu Glu Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu 
    1730                 1735                 1740             


Pro Ser  Gly Glu Ala Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp 
    1745                 1750                 1755             


Val Ser  Gly Gln Phe Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr 
    1760                 1765                 1770             


Ser Gln  Thr Pro Glu Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu 
    1775                 1780                 1785             


Val Ser  Gly Glu Ser Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro 
    1790                 1795                 1800             


Ser Gly  Ala Tyr Tyr Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr 
    1805                 1810                 1815             


Val Ser  Leu Val Asp Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala 
    1820                 1825                 1830             


Pro Thr  Ala Gln Glu Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu 
    1835                 1840                 1845             


Leu Ser  Gly Ala His Ser Gly  Ala Pro Asp Met Ser  Gly Glu His 
    1850                 1855                 1860             


Ser Gly  Phe Leu Asp Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu 
    1865                 1870                 1875             


Pro Ser  Gly Glu Pro Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe 
    1880                 1885                 1890             


Ala Ser  Thr Thr Asn Val Ser  Gly Glu Ser Ser Val  Ala Met Gly 
    1895                 1900                 1905             


Thr Ser  Gly Glu Ala Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr 
    1910                 1915                 1920             


Ser Glu  Phe Val Glu Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu 
    1925                 1930                 1935             


Leu Gly  Gln Arg Pro Pro Val  Thr His Thr Pro Gln  Leu Phe Glu 
    1940                 1945                 1950             


Ser Ser  Gly Lys Val Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr 
    1955                 1960                 1965             


Pro Val  Leu Pro Gly Ser Gly  Val Glu Val Ser Ser  Val Pro Glu 
    1970                 1975                 1980             


Ser Ser  Ser Glu Thr Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala 
    1985                 1990                 1995             


Ser Ala  Ala Pro Glu Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp 
    2000                 2005                 2010             


Leu Ser  Glu Thr Thr Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg 
    2015                 2020                 2025             


Ser Ser  Gly Leu Gly Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu 
    2030                 2035                 2040             


Gly Glu  Ala Ser Ala Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr 
    2045                 2050                 2055             


Thr Ser  Asp Val Gly Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr 
    2060                 2065                 2070             


Pro Thr  Ala Ser Gly Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser 
    2075                 2080                 2085             


Gly His  Thr Ser Gln Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro 
    2090                 2095                 2100             


Glu Ser  Glu Trp Thr Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His 
    2105                 2110                 2115             


Leu Glu  Ile Glu Ser Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr 
    2120                 2125                 2130             


His Thr  Val Glu Thr Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro 
    2135                 2140                 2145             


Ala Ser  Pro Glu Trp Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Ala 
    2150                 2155                 2160             


Pro Ala  Arg Ser Cys Ala Glu  Glu Pro Cys Gly Ala  Gly Thr Cys 
    2165                 2170                 2175             


Lys Glu  Thr Glu Gly His Val  Ile Cys Leu Cys Pro  Pro Gly Tyr 
    2180                 2185                 2190             


Thr Gly  Glu His Cys Asn Ile  Asp Gln Glu Val Cys  Glu Glu Gly 
    2195                 2200                 2205             


Trp Asn  Lys Tyr Gln Gly His  Cys Tyr Arg His Phe  Pro Asp Arg 
    2210                 2215                 2220             


Glu Thr  Trp Val Asp Ala Glu  Arg Arg Cys Arg Glu  Gln Gln Ser 
    2225                 2230                 2235             


His Leu  Ser Ser Ile Val Thr  Pro Glu Glu Gln Glu  Phe Val Asn 
    2240                 2245                 2250             


Asn Asn  Ala Gln Asp Tyr Gln  Trp Ile Gly Leu Asn  Asp Arg Thr 
    2255                 2260                 2265             


Ile Glu  Gly Asp Phe Arg Trp  Ser Asp Gly His Pro  Met Gln Phe 
    2270                 2275                 2280             


Glu Asn  Trp Arg Pro Asn Gln  Pro Asp Asn Phe Phe  Ala Ala Gly 
    2285                 2290                 2295             


Glu Asp  Cys Val Val Met Ile  Trp His Glu Lys Gly  Glu Trp Asn 
    2300                 2305                 2310             


Asp Val  Pro Cys Asn Tyr His  Leu Pro Phe Thr Cys  Lys Lys Gly 
    2315                 2320                 2325             


Thr Val  Ala Cys Gly Glu Pro  Pro Val Val Glu His  Ala Arg Thr 
    2330                 2335                 2340             


Phe Gly  Gln Lys Lys Asp Arg  Tyr Glu Ile Asn Ser  Leu Val Arg 
    2345                 2350                 2355             


Tyr Gln  Cys Thr Glu Gly Phe  Val Gln Arg His Met  Pro Thr Ile 
    2360                 2365                 2370             


Arg Cys  Gln Pro Ser Gly His  Trp Glu Glu Pro Arg  Ile Thr Cys 
    2375                 2380                 2385             


Thr Asp  Ala Thr Thr Tyr Lys  Arg Arg Leu Gln Lys  Arg Ser Ser 
    2390                 2395                 2400             


Arg His  Pro Arg Arg Ser Arg  Pro Ser Thr Ala His  
    2405                 2410                 2415 


<210>  144
<211>  359
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human decorin

<400>  144

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
            180                 185                 190         


Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
        195                 200                 205             


Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
    210                 215                 220                 


Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
225                 230                 235                 240 


Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                245                 250                 255     


Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
            260                 265                 270         


Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
        275                 280                 285             


Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
    290                 295                 300                 


Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
305                 310                 315                 320 


Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                325                 330                 335     


Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
            340                 345                 350         


Ile Gln Leu Gly Asn Tyr Lys 
        355                 


<210>  145
<211>  368
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human biglycan

<400>  145

Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly 
            20                  25                  30          


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly 
        35                  40                  45              


Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro 
    50                  55                  60                  


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
65                  70                  75                  80  


Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp 
                85                  90                  95      


Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly 
            100                 105                 110         


Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser Lys 
        115                 120                 125             


Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr 
    130                 135                 140                 


Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser 
145                 150                 155                 160 


Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys 
                165                 170                 175     


Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly 
            180                 185                 190         


Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu 
        195                 200                 205             


Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro 
    210                 215                 220                 


Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn Lys 
225                 230                 235                 240 


Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr 
                245                 250                 255     


Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser 
            260                 265                 270         


Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys 
        275                 280                 285             


Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val 
    290                 295                 300                 


Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe 
305                 310                 315                 320 


Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser 
                325                 330                 335     


Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe 
            340                 345                 350         


Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
        355                 360                 365             


<210>  146
<211>  376
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human fibromodulin

<400>  146

Met Gln Trp Thr Ser Leu Leu Leu Leu Ala Gly Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gln Ala Gln Tyr Glu Asp Asp Pro His Trp Trp Phe His Tyr Leu Arg 
            20                  25                  30          


Ser Gln Gln Ser Thr Tyr Tyr Asp Pro Tyr Asp Pro Tyr Pro Tyr Glu 
        35                  40                  45              


Thr Tyr Glu Pro Tyr Pro Tyr Gly Val Asp Glu Gly Pro Ala Tyr Thr 
    50                  55                  60                  


Tyr Gly Ser Pro Ser Pro Pro Asp Pro Arg Asp Cys Pro Gln Glu Cys 
65                  70                  75                  80  


Asp Cys Pro Pro Asn Phe Pro Thr Ala Met Tyr Cys Asp Asn Arg Asn 
                85                  90                  95      


Leu Lys Tyr Leu Pro Phe Val Pro Ser Arg Met Lys Tyr Val Tyr Phe 
            100                 105                 110         


Gln Asn Asn Gln Ile Thr Ser Ile Gln Glu Gly Val Phe Asp Asn Ala 
        115                 120                 125             


Thr Gly Leu Leu Trp Ile Ala Leu His Gly Asn Gln Ile Thr Ser Asp 
    130                 135                 140                 


Lys Val Gly Arg Lys Val Phe Ser Lys Leu Arg His Leu Glu Arg Leu 
145                 150                 155                 160 


Tyr Leu Asp His Asn Asn Leu Thr Arg Met Pro Gly Pro Leu Pro Arg 
                165                 170                 175     


Ser Leu Arg Glu Leu His Leu Asp His Asn Gln Ile Ser Arg Val Pro 
            180                 185                 190         


Asn Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu Tyr Leu Gln 
        195                 200                 205             


His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Arg Gly Leu Arg Ser 
    210                 215                 220                 


Leu Ile Leu Leu Asp Leu Ser Tyr Asn His Leu Arg Lys Val Pro Asp 
225                 230                 235                 240 


Gly Leu Pro Ser Ala Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val 
                245                 250                 255     


Tyr Thr Val Pro Asp Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr 
            260                 265                 270         


Val Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn 
        275                 280                 285             


Thr Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln 
    290                 295                 300                 


Leu Gln Lys Ile Pro Pro Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu 
305                 310                 315                 320 


Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe Cys Thr Val 
                325                 330                 335     


Val Asp Val Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp Gly 
            340                 345                 350         


Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys Leu 
        355                 360                 365             


Arg Leu Ala Ser Leu Ile Glu Ile 
    370                 375     


<210>  147
<211>  1487
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human type II collagen

<400>  147

Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 
        35                  40                  45              


Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 
    50                  55                  60                  


Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 
65                  70                  75                  80  


Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 
                85                  90                  95      


Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 
            100                 105                 110         


Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 
    130                 135                 140                 


Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 
                165                 170                 175     


Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 
            180                 185                 190         


Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 
        195                 200                 205             


Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
    210                 215                 220                 


Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 
225                 230                 235                 240 


Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 
                245                 250                 255     


Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 
            260                 265                 270         


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 
        275                 280                 285             


His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 
    290                 295                 300                 


Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 
305                 310                 315                 320 


Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 
                325                 330                 335     


Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 
    370                 375                 380                 


Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 
                405                 410                 415     


Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 
            420                 425                 430         


Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 
        435                 440                 445             


Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 
    450                 455                 460                 


Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 
465                 470                 475                 480 


Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 
                485                 490                 495     


Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 
        515                 520                 525             


Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 
    530                 535                 540                 


Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 
545                 550                 555                 560 


Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 
                565                 570                 575     


Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
            580                 585                 590         


Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 
        595                 600                 605             


Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 
    610                 615                 620                 


Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 
625                 630                 635                 640 


Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 
                645                 650                 655     


Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 
    690                 695                 700                 


Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 
                725                 730                 735     


Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 
            740                 745                 750         


Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 
        755                 760                 765             


Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 
    770                 775                 780                 


Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 
                805                 810                 815     


Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 
            820                 825                 830         


Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 
        835                 840                 845             


Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 
865                 870                 875                 880 


Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 
                885                 890                 895     


Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 
        915                 920                 925             


Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
    930                 935                 940                 


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
945                 950                 955                 960 


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 
                965                 970                 975     


Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 
            980                 985                 990         


Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 
        995                 1000                 1005             


Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Gly  Pro Val Gly 
    1010                 1015                 1020             


Pro Pro  Gly Leu Thr Gly Pro  Ala Gly Glu Pro Gly  Arg Glu Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Asp Gly Pro  Pro Gly Arg Asp Gly  Ala Ala Gly 
    1040                 1045                 1050             


Val Lys  Gly Asp Arg Gly Glu  Thr Gly Ala Val Gly  Ala Pro Gly 
    1055                 1060                 1065             


Ala Pro  Gly Pro Pro Gly Ser  Pro Gly Pro Ala Gly  Pro Thr Gly 
    1070                 1075                 1080             


Lys Gln  Gly Asp Arg Gly Glu  Ala Gly Ala Gln Gly  Pro Met Gly 
    1085                 1090                 1095             


Pro Ser  Gly Pro Ala Gly Ala  Arg Gly Ile Gln Gly  Pro Gln Gly 
    1100                 1105                 1110             


Pro Arg  Gly Asp Lys Gly Glu  Ala Gly Glu Pro Gly  Glu Arg Gly 
    1115                 1120                 1125             


Leu Lys  Gly His Arg Gly Phe  Thr Gly Leu Gln Gly  Leu Pro Gly 
    1130                 1135                 1140             


Pro Pro  Gly Pro Ser Gly Asp  Gln Gly Ala Ser Gly  Pro Ala Gly 
    1145                 1150                 1155             


Pro Ser  Gly Pro Arg Gly Pro  Pro Gly Pro Val Gly  Pro Ser Gly 
    1160                 1165                 1170             


Lys Asp  Gly Ala Asn Gly Ile  Pro Gly Pro Ile Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Arg  Gly Arg Ser Gly Glu  Thr Gly Pro Ala Gly  Pro Pro Gly 
    1190                 1195                 1200             


Asn Pro  Gly Pro Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Gly Ile 
    1205                 1210                 1215             


Asp Met  Ser Ala Phe Ala Gly  Leu Gly Pro Arg Glu  Lys Gly Pro 
    1220                 1225                 1230             


Asp Pro  Leu Gln Tyr Met Arg  Ala Asp Gln Ala Ala  Gly Gly Leu 
    1235                 1240                 1245             


Arg Gln  His Asp Ala Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1250                 1255                 1260             


Asn Gln  Ile Glu Ser Ile Arg  Ser Pro Glu Gly Ser  Arg Lys Asn 
    1265                 1270                 1275             


Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Leu Cys His  Pro Glu Trp 
    1280                 1285                 1290             


Lys Ser  Gly Asp Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Leu 
    1295                 1300                 1305             


Asp Ala  Met Lys Val Phe Cys  Asn Met Glu Thr Gly  Glu Thr Cys 
    1310                 1315                 1320             


Val Tyr  Pro Asn Pro Ala Asn  Val Pro Lys Lys Asn  Trp Trp Ser 
    1325                 1330                 1335             


Ser Lys  Ser Lys Glu Lys Lys  His Ile Trp Phe Gly  Glu Thr Ile 
    1340                 1345                 1350             


Asn Gly  Gly Phe His Phe Ser  Tyr Gly Asp Asp Asn  Leu Ala Pro 
    1355                 1360                 1365             


Asn Thr  Ala Asn Val Gln Met  Thr Phe Leu Arg Leu  Leu Ser Thr 
    1370                 1375                 1380             


Glu Gly  Ser Gln Asn Ile Thr  Tyr His Cys Lys Asn  Ser Ile Ala 
    1385                 1390                 1395             


Tyr Leu  Asp Glu Ala Ala Gly  Asn Leu Lys Lys Ala  Leu Leu Ile 
    1400                 1405                 1410             


Gln Gly  Ser Asn Asp Val Glu  Ile Arg Ala Glu Gly  Asn Ser Arg 
    1415                 1420                 1425             


Phe Thr  Tyr Thr Ala Leu Lys  Asp Gly Cys Thr Lys  His Thr Gly 
    1430                 1435                 1440             


Lys Trp  Gly Lys Thr Val Ile  Glu Tyr Arg Ser Gln  Lys Thr Ser 
    1445                 1450                 1455             


Arg Leu  Pro Ile Ile Asp Ile  Ala Pro Met Asp Ile  Gly Gly Pro 
    1460                 1465                 1470             


Glu Gln  Glu Phe Gly Val Asp  Ile Gly Pro Val Cys  Phe Leu 
    1475                 1480                 1485         


<210>  148
<211>  569
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human IL-1R type 1

<400>  148

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  149
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  C3957_IL1Ra_Coll2mutM26_NA

<400>  149
atgcatcatc atcatcatca tgaaaacctg tacttccaac gaccgtccgg ccgtaagagc       60

tccaaaatgc aggctttccg tatctgggac gttaaccaga aaaccttcta cctgcgcaac      120

aaccagctgg ttgctggcta cctgcagggt ccgaacgtta acctggaaga aaaaatcgac      180

gttgtaccga tcgaaccgca cgctctgttc ctgggtatcc acggtggtaa aatgtgcctg      240

agctgcgtga aatctggtga cgaaactcgt ctgcagctgg aagcagttaa catcactgac      300

ctgagcgaaa accgcaaaca ggacaaacgt ttcgcattca tccgctctga cagcggcccg      360

accaccagct tcgaatctgc tgcttgcccg ggttggttcc tgtgcactgc tatggaagct      420

gaccagccgg taagcctgac caacatgccg gacgaaggcg tgatggtaac caaattctac      480

ttccaggaag acgaaggtgg cggtggttct ggcggcggcg gttcttgtat gccgaaccag      540

ttcaagtgca ggtcgtcgag gacgtgcctc ctaccggagt gggtttgcga cggcattgat      600

gattgtccgg acggatcgga tgaatcgccg actaactgtc caacgcctac gtag            654


<210>  150
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  C3957_IL1Ra_Coll2mutM26_AA

<400>  150

Met His His His His His His Glu Asn Leu Tyr Phe Gln Arg Pro Ser 
1               5                   10                  15      


Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn 
            20                  25                  30          


Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu 
        35                  40                  45              


Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile 
    50                  55                  60                  


Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu 
65                  70                  75                  80  


Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val 
                85                  90                  95      


Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala 
            100                 105                 110         


Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala 
        115                 120                 125             


Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val 
    130                 135                 140                 


Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr 
145                 150                 155                 160 


Phe Gln Glu Asp Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys 
                165                 170                 175     


Met Pro Asn Gln Phe Lys Cys Arg Ser Ser Arg Thr Cys Leu Leu Pro 
            180                 185                 190         


Glu Trp Val Cys Asp Gly Ile Asp Asp Cys Pro Asp Gly Ser Asp Glu 
        195                 200                 205             


Ser Pro Thr Asn Cys Pro Thr Pro Thr 
    210                 215         


<210>  151
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  C3774_Coll2mutM26_NA

<400>  151
atggccggtc cggcctaccc gtatgatgtt ccggattatg ccccgggtct ggaggcgtct       60

ggtggttcgt gtatgccgaa ccagttcaag tgcaggtcgt cgaggacgtg cctcctaccg      120

gagtgggttt gcgacggcat tgatgattgt ccggacggat cggatgaatc gccgactaac      180

tgtccaacgc ctacgtcatt gcagaaggcc tctggggccc tcgagcacca ccaccaccac      240

caccaccact aa                                                          252


<210>  152
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  C3774_Coll2mutM26_AA

<400>  152

Met Ala Gly Pro Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
1               5                   10                  15      


Leu Glu Ala Ser Gly Gly Ser Cys Met Pro Asn Gln Phe Lys Cys Arg 
            20                  25                  30          


Ser Ser Arg Thr Cys Leu Leu Pro Glu Trp Val Cys Asp Gly Ile Asp 
        35                  40                  45              


Asp Cys Pro Asp Gly Ser Asp Glu Ser Pro Thr Asn Cys Pro Thr Pro 
    50                  55                  60                  


Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu Glu His His His His His 
65                  70                  75                  80  


His His His 
            


<210>  153
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  C3511_C2730IL1RWD05_NA

<400>  153
atggccggtc cggcctaccc gtatgatgtt ccggattatg ccccgggcct ggaggcgtct       60

ggtggttcgt gtcctccgaa cgagttcagg tgcaacagcg gccaatgcat tccaccgcac      120

tggctctgcg acggcgatga tgattgtcgg gacggctcgg atgaaacaga ctgtacagag      180

cttacgtgtc gggcagacga gttcccgtgc gacaacggca gctgcgttcc actacgctgg      240

cgctgcgacg gcgtaaatga ttgtggtgac agctcggatg aatcgccgtc acactgtgaa      300

gcgcgtacgt cattgcagaa ggcctctggg gccctcgagc accaccacca ccaccaccac      360

cactaa                                                                 366


<210>  154
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  C3511_C2730IL1RWD05_AA

<400>  154

Met Ala Gly Pro Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Gly 
1               5                   10                  15      


Leu Glu Ala Ser Gly Gly Ser Cys Pro Pro Asn Glu Phe Arg Cys Asn 
            20                  25                  30          


Ser Gly Gln Cys Ile Pro Pro His Trp Leu Cys Asp Gly Asp Asp Asp 
        35                  40                  45              


Cys Arg Asp Gly Ser Asp Glu Thr Asp Cys Thr Glu Leu Thr Cys Arg 
    50                  55                  60                  


Ala Asp Glu Phe Pro Cys Asp Asn Gly Ser Cys Val Pro Leu Arg Trp 
65                  70                  75                  80  


Arg Cys Asp Gly Val Asn Asp Cys Gly Asp Ser Ser Asp Glu Ser Pro 
                85                  90                  95      


Ser His Cys Glu Ala Arg Thr Ser Leu Gln Lys Ala Ser Gly Ala Leu 
            100                 105                 110         


Glu His His His His His His His His 
        115                 120     


