                               SEQUENCE LISTING

<110> HOUGH EAR INSTITUTE
 
<120> COMBINATION THERAPIES FOR INNER EAR SENSORY HAIR CELL 
      REGENERATION/REPLACEMENT

<130> 109255-0402

<140> PCT/US2017/035673
<141> 2017-06-02

<150> 62/345,740
<151> 2016-06-03

<160> 27    

<170> PatentIn version 3.5

<210> 1
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present

<400> 1
cagcugauau aauggagaat t                                                 21


<210> 2
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present

<400> 2
uucuccauua uaucagcugt t                                                 21


<210> 3
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 3
gaagggcaag aauaaaugat t                                                 21


<210> 4
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 4
ucauuuauuc uugcccuuct t                                                 21


<210> 5
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 5
gaugccaaag auguuugaat t                                                 21


<210> 6
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 6
uucaaacauc uuuggcauct t                                                 21


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 7
caacacgaca ccggauaaat t                                                 21


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 8
uuuauccggu gucguguugt t                                                 21


<210> 9
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 9
ggauugcgcc uuuguauuat t                                                 21


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 10
uaauacaaag gcgcaaucct t                                                 21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 11
gcucagauga cauuucguut t                                                 21


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 12
aacgaaaugu caucugagct t                                                 21


<210> 13
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
acugcaugac ccagaucaa                                                    19


<210> 14
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
uugaucuggg ucaugcagu                                                    19


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 15
gcaucaacag cagcauagat t                                                 21


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 16
ucuaugcugc uguugaugct t                                                 21


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 17
ggucauucuu agagaaugut t                                                 21


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 18
acauucucua agaaugacct t                                                 21


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 19
cgaugauccu uaaaggauut t                                                 21


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 20
aauccuuuaa ggaucaucgt t                                                 21


<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 21
ugcugacucc aaagcucugt t                                                 21


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 22
cagagcuuug gagucagcat t                                                 21


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (20)..(21) 
<223> May or may not be present 

<400> 23
ggguauucuu ggaucuccat t                                                 21


<210> 24
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
uggagaucca agaauaccca g                                                 21


<210> 25
<211> 280
<212> PRT
<213> Homo sapiens

<400> 25
Met Pro Ala Asp Ile Met Glu Lys Asn Ser Ser Ser Pro Val Ala Ala 
1               5                   10                  15      


Thr Pro Ala Ser Val Asn Thr Thr Pro Asp Lys Pro Lys Thr Ala Ser 
            20                  25                  30          


Glu His Arg Lys Ser Ser Lys Pro Ile Met Glu Lys Arg Arg Arg Ala 
        35                  40                  45              


Arg Ile Asn Glu Ser Leu Ser Gln Leu Lys Thr Leu Ile Leu Asp Ala 
    50                  55                  60                  


Leu Lys Lys Asp Ser Ser Arg His Ser Lys Leu Glu Lys Ala Asp Ile 
65                  70                  75                  80  


Leu Glu Met Thr Val Lys His Leu Arg Asn Leu Gln Arg Ala Gln Met 
                85                  90                  95      


Thr Ala Ala Leu Ser Thr Asp Pro Ser Val Leu Gly Lys Tyr Arg Ala 
            100                 105                 110         


Gly Phe Ser Glu Cys Met Asn Glu Val Thr Arg Phe Leu Ser Thr Cys 
        115                 120                 125             


Glu Gly Val Asn Thr Glu Val Arg Thr Arg Leu Leu Gly His Leu Ala 
    130                 135                 140                 


Asn Cys Met Thr Gln Ile Asn Ala Met Thr Tyr Pro Gly Gln Pro His 
145                 150                 155                 160 


Pro Ala Leu Gln Ala Pro Pro Pro Pro Pro Pro Gly Pro Gly Gly Pro 
                165                 170                 175     


Gln His Ala Pro Phe Ala Pro Pro Pro Pro Leu Val Pro Ile Pro Gly 
            180                 185                 190         


Gly Ala Ala Pro Pro Pro Gly Gly Ala Pro Cys Lys Leu Gly Ser Gln 
        195                 200                 205             


Ala Gly Glu Ala Ala Lys Val Phe Gly Gly Phe Gln Val Val Pro Ala 
    210                 215                 220                 


Pro Asp Gly Gln Phe Ala Phe Leu Ile Pro Asn Gly Ala Phe Ala His 
225                 230                 235                 240 


Ser Gly Pro Val Ile Pro Val Tyr Thr Ser Asn Ser Gly Thr Ser Val 
                245                 250                 255     


Gly Pro Asn Ala Val Ser Pro Ser Ser Gly Pro Ser Leu Thr Ala Asp 
            260                 265                 270         


Ser Met Trp Arg Pro Trp Arg Asn 
        275                 280 


<210> 26
<211> 166
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Pro Ser Thr Val Ala Val Glu Leu Leu Ser Pro Lys Glu Lys 
1               5                   10                  15      


Asn Arg Leu Arg Lys Pro Val Val Glu Lys Met Arg Arg Asp Arg Ile 
            20                  25                  30          


Asn Ser Ser Ile Glu Gln Leu Lys Leu Leu Leu Glu Gln Glu Phe Ala 
        35                  40                  45              


Arg His Gln Pro Asn Ser Lys Leu Glu Lys Ala Asp Ile Leu Glu Met 
    50                  55                  60                  


Ala Val Ser Tyr Leu Lys His Ser Lys Ala Phe Val Ala Ala Ala Gly 
65                  70                  75                  80  


Pro Lys Ser Leu His Gln Asp Tyr Ser Glu Gly Tyr Ser Trp Cys Leu 
                85                  90                  95      


Gln Glu Ala Val Gln Phe Leu Thr Leu His Ala Ala Ser Asp Thr Gln 
            100                 105                 110         


Met Lys Leu Leu Tyr His Phe Gln Arg Pro Pro Ala Ala Pro Ala Ala 
        115                 120                 125             


Pro Ala Lys Glu Pro Lys Ala Pro Gly Ala Ala Pro Pro Pro Ala Leu 
    130                 135                 140                 


Ser Ala Lys Ala Thr Ala Ala Ala Ala Ala Ala His Gln Pro Ala Cys 
145                 150                 155                 160 


Gly Leu Trp Arg Pro Trp 
                165     


<210> 27
<211> 360
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


