                         SEQUENCE LISTING

<110>  Carnegie Mellon University
       Massachusetts Institute of Technology
 
<120>  MICROFLUIDIC-BASED MULTIPLEX CELL ASSAY FOR DRUG COMPOUND TESTING

<130>  C0786.70004WO00

<140>  Not Yet Assigned
<141>  2017-06-01

<150>  US 62/344,352
<151>  2016-06-01

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2478
<212>  PRT
<213>  Bos taurus

<400>  1

Met Leu Gly Gly Pro Gly Pro Gly Leu Leu Leu Leu Leu Ala Val Leu 
1               5                   10                  15      


Ser Leu Gly Thr Ala Val Pro Ser Ala Gly Ala Ser Lys Ser Arg Arg 
            20                  25                  30          


Gln Ala Gln Gln Ile Val Gln Pro Gln Ser Pro Leu Thr Val Ser Gln 
        35                  40                  45              


Ser Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln 
    50                  55                  60                  


Gln Trp Glu Arg Thr Tyr Leu Gly Ser Ala Leu Val Cys Thr Cys Tyr 
65                  70                  75                  80  


Gly Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Pro Glu Glu 
                85                  90                  95      


Thr Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr 
            100                 105                 110         


Tyr Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly 
        115                 120                 125             


Ala Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu 
    130                 135                 140                 


Gly Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu 
145                 150                 155                 160 


Thr Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly 
                165                 170                 175     


Glu Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp Gln Ala Ala 
            180                 185                 190         


Gly Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly 
        195                 200                 205             


Trp Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile 
    210                 215                 220                 


Thr Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser 
225                 230                 235                 240 


Tyr Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu 
                245                 250                 255     


Leu Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu 
            260                 265                 270         


Arg His Thr Ser Leu Gln Thr Thr Ser Ala Gly Ser Gly Ser Phe Thr 
        275                 280                 285             


Asp Val Arg Thr Ala Ile Tyr Gln Pro Gln Pro His Pro Gln Pro Pro 
    290                 295                 300                 


Pro Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly 
305                 310                 315                 320 


Met Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys 
                325                 330                 335     


Leu Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr 
            340                 345                 350         


Gly Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn 
        355                 360                 365             


Gly Lys Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His 
    370                 375                 380                 


Leu Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser 
385                 390                 395                 400 


Phe Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser 
                405                 410                 415     


Asn Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr 
            420                 425                 430         


Thr Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly 
        435                 440                 445             


Thr Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met 
    450                 455                 460                 


Ala Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg 
465                 470                 475                 480 


Ile Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg 
                485                 490                 495     


Cys Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Val Ala Tyr 
            500                 505                 510         


Ser Gln Leu Arg Asp Gln Cys Ile Val Asp Gly Ile Thr Tyr Asn Val 
        515                 520                 525             


Asn Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys 
    530                 535                 540                 


Thr Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp 
545                 550                 555                 560 


Gln Cys Gln Asp Ser Glu Thr Arg Thr Phe Tyr Gln Ile Gly Asp Ser 
                565                 570                 575     


Trp Glu Lys Tyr Leu Gln Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly 
            580                 585                 590         


Arg Gly Ile Gly Glu Trp Ala Cys Gln Pro Leu Gln Thr Tyr Pro Asp 
        595                 600                 605             


Thr Ser Gly Pro Val Gln Val Ile Ile Thr Glu Thr Pro Ser Gln Pro 
    610                 615                 620                 


Asn Ser His Pro Ile Gln Trp Ser Ala Pro Glu Ser Ser His Ile Ser 
625                 630                 635                 640 


Lys Tyr Ile Leu Arg Trp Lys Pro Lys Asn Ser Pro Asp Arg Trp Lys 
                645                 650                 655     


Glu Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu 
            660                 665                 670         


Arg Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Val Gln His Tyr 
        675                 680                 685             


Gly Gln Arg Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser 
    690                 695                 700                 


Pro Ala Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Leu Ser 
705                 710                 715                 720 


Pro Val Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser 
                725                 730                 735     


Phe Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg 
            740                 745                 750         


Val Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp 
        755                 760                 765             


Leu Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly 
    770                 775                 780                 


Arg Lys Tyr Thr Val Asn Val Tyr Glu Ile Ser Glu Glu Gly Glu Gln 
785                 790                 795                 800 


Asn Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro 
                805                 810                 815     


Asp Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp 
            820                 825                 830         


Ser Arg Pro Arg Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro 
        835                 840                 845             


Ser Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn 
    850                 855                 860                 


Ser Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr 
865                 870                 875                 880 


Ile Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Phe Ile Gln 
                885                 890                 895     


Gln Glu Thr Thr Gly Val Pro Arg Ser Asp Lys Val Pro Pro Pro Arg 
            900                 905                 910         


Asp Leu Gln Phe Val Glu Val Thr Asp Val Lys Ile Thr Ile Met Trp 
        915                 920                 925             


Thr Pro Pro Glu Ser Pro Val Thr Gly Tyr Arg Val Asp Val Ile Pro 
    930                 935                 940                 


Val Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Val Ser Arg Asn 
945                 950                 955                 960 


Thr Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr His Phe 
                965                 970                 975     


Lys Val Phe Ala Val Asn Gln Gly Arg Glu Ser Lys Pro Leu Thr Ala 
            980                 985                 990         


Gln Gln Ala Thr Lys Leu Asp Ala  Pro Thr Asn Leu Gln  Phe Ile Asn 
        995                 1000                 1005             


Glu Thr  Asp Thr Thr Val Ile  Val Thr Trp Thr Pro  Pro Arg Ala 
    1010                 1015                 1020             


Arg Ile  Val Gly Tyr Arg Leu  Thr Val Gly Leu Thr  Arg Gly Gly 
    1025                 1030                 1035             


Gln Pro  Lys Gln Tyr Asn Val  Gly Pro Ala Ala Ser  Gln Tyr Pro 
    1040                 1045                 1050             


Leu Arg  Asn Leu Gln Pro Gly  Ser Glu Tyr Ala Val  Ser Leu Val 
    1055                 1060                 1065             


Ala Val  Lys Gly Asn Gln Gln  Ser Pro Arg Val Thr  Gly Val Phe 
    1070                 1075                 1080             


Thr Thr  Leu Gln Pro Leu Gly  Ser Ile Pro His Tyr  Asn Thr Glu 
    1085                 1090                 1095             


Val Thr  Glu Thr Thr Ile Val  Ile Thr Trp Thr Pro  Ala Pro Arg 
    1100                 1105                 1110             


Ile Gly  Phe Lys Leu Gly Val  Arg Pro Ser Gln Gly  Gly Glu Ala 
    1115                 1120                 1125             


Pro Arg  Glu Val Thr Ser Glu  Ser Gly Ser Ile Val  Val Ser Gly 
    1130                 1135                 1140             


Leu Thr  Pro Gly Val Glu Tyr  Val Tyr Thr Ile Ser  Val Leu Arg 
    1145                 1150                 1155             


Asp Gly  Gln Glu Arg Asp Ala  Pro Ile Val Lys Lys  Val Val Thr 
    1160                 1165                 1170             


Pro Leu  Ser Pro Pro Thr Asn  Leu His Leu Glu Ala  Asn Pro Asp 
    1175                 1180                 1185             


Thr Gly  Val Leu Thr Val Ser  Trp Glu Arg Ser Thr  Thr Pro Asp 
    1190                 1195                 1200             


Ile Thr  Gly Tyr Arg Ile Thr  Thr Thr Pro Thr Asn  Gly Gln Gln 
    1205                 1210                 1215             


Gly Tyr  Ser Leu Glu Glu Val  Val His Ala Asp Gln  Ser Ser Cys 
    1220                 1225                 1230             


Thr Phe  Glu Asn Leu Ser Pro  Gly Leu Glu Tyr Asn  Val Ser Val 
    1235                 1240                 1245             


Tyr Thr  Val Lys Asp Asp Lys  Glu Ser Val Pro Ile  Ser Asp Thr 
    1250                 1255                 1260             


Ile Ile  Pro Glu Val Pro Gln  Leu Thr Asp Leu Ser  Phe Val Asp 
    1265                 1270                 1275             


Ile Thr  Asp Ser Ser Ile Gly  Leu Arg Trp Thr Pro  Leu Asn Ser 
    1280                 1285                 1290             


Ser Thr  Ile Ile Gly Tyr Arg  Ile Thr Val Val Ala  Ala Gly Glu 
    1295                 1300                 1305             


Gly Ile  Pro Ile Phe Glu Asp  Phe Val Asp Ser Ser  Val Gly Tyr 
    1310                 1315                 1320             


Tyr Thr  Val Thr Gly Leu Glu  Pro Gly Ile Asp Tyr  Asp Ile Ser 
    1325                 1330                 1335             


Val Ile  Thr Leu Ile Asn Gly  Gly Glu Ser Ala Pro  Thr Thr Leu 
    1340                 1345                 1350             


Thr Gln  Gln Thr Ala Val Pro  Pro Pro Thr Asp Leu  Arg Phe Thr 
    1355                 1360                 1365             


Asn Val  Gly Pro Asp Thr Met  Arg Val Thr Trp Ala  Pro Pro Ser 
    1370                 1375                 1380             


Ser Ile  Glu Leu Thr Asn Leu  Leu Val Arg Tyr Ser  Pro Val Lys 
    1385                 1390                 1395             


Asn Glu  Glu Asp Val Ala Glu  Leu Ser Ile Ser Pro  Ser Asp Asn 
    1400                 1405                 1410             


Ala Val  Val Leu Thr Asn Leu  Leu Pro Gly Thr Glu  Tyr Leu Val 
    1415                 1420                 1425             


Ser Val  Ser Ser Val Tyr Glu  Gln His Glu Ser Ile  Pro Leu Arg 
    1430                 1435                 1440             


Gly Arg  Gln Lys Thr Ala Leu  Asp Ser Pro Ser Gly  Ile Asp Phe 
    1445                 1450                 1455             


Ser Asp  Ile Thr Ala Asn Ser  Phe Thr Val His Trp  Ile Ala Pro 
    1460                 1465                 1470             


Arg Ala  Thr Ile Thr Gly Tyr  Arg Ile Arg His His  Pro Glu Asn 
    1475                 1480                 1485             


Met Gly  Gly Arg Pro Arg Glu  Asp Arg Val Pro Pro  Ser Arg Asn 
    1490                 1495                 1500             


Ser Ile  Thr Leu Thr Asn Leu  Asn Pro Gly Thr Glu  Tyr Val Val 
    1505                 1510                 1515             


Ser Ile  Val Ala Leu Asn Ser  Lys Glu Glu Ser Leu  Pro Leu Val 
    1520                 1525                 1530             


Gly Gln  Gln Ser Thr Val Ser  Asp Val Pro Arg Asp  Leu Glu Val 
    1535                 1540                 1545             


Ile Ala  Ala Thr Pro Thr Ser  Leu Leu Ile Ser Trp  Asp Ala Pro 
    1550                 1555                 1560             


Ala Val  Thr Val Arg Tyr Tyr  Arg Ile Thr Tyr Gly  Glu Thr Gly 
    1565                 1570                 1575             


Gly Ser  Ser Pro Val Gln Glu  Phe Thr Val Pro Gly  Ser Lys Ser 
    1580                 1585                 1590             


Thr Ala  Thr Ile Ser Gly Leu  Lys Pro Gly Val Asp  Tyr Thr Ile 
    1595                 1600                 1605             


Thr Val  Tyr Ala Val Thr Gly  Arg Gly Asp Ser Pro  Ala Ser Ser 
    1610                 1615                 1620             


Lys Pro  Val Ser Ile Asn Tyr  Arg Thr Glu Ile Asp  Lys Pro Ser 
    1625                 1630                 1635             


Gln Met  Gln Val Thr Asp Val  Gln Asp Asn Ser Ile  Ser Val Arg 
    1640                 1645                 1650             


Trp Leu  Pro Ser Ser Ser Pro  Val Thr Gly Tyr Arg  Val Thr Thr 
    1655                 1660                 1665             


Ala Pro  Lys Asn Gly Pro Gly  Pro Ser Lys Thr Lys  Thr Val Gly 
    1670                 1675                 1680             


Pro Asp  Gln Thr Glu Met Thr  Ile Glu Gly Leu Gln  Pro Thr Val 
    1685                 1690                 1695             


Glu Tyr  Val Val Ser Val Tyr  Ala Gln Asn Gln Asn  Gly Glu Ser 
    1700                 1705                 1710             


Gln Pro  Leu Val Gln Thr Ala  Val Thr Asn Ile Asp  Arg Pro Lys 
    1715                 1720                 1725             


Gly Leu  Ala Phe Thr Asp Val  Asp Val Asp Ser Ile  Lys Ile Ala 
    1730                 1735                 1740             


Trp Glu  Ser Pro Gln Gly Gln  Val Ser Arg Tyr Arg  Val Thr Tyr 
    1745                 1750                 1755             


Ser Ser  Pro Glu Asp Gly Ile  His Glu Leu Phe Pro  Ala Pro Asp 
    1760                 1765                 1770             


Gly Glu  Glu Glu Thr Ala Glu  Leu Gln Gly Leu Arg  Pro Gly Ser 
    1775                 1780                 1785             


Glu Tyr  Thr Val Ser Val Val  Ala Leu His Asp Asp  Met Glu Ser 
    1790                 1795                 1800             


Gln Pro  Leu Ile Gly Thr Gln  Ser Thr Thr Ile Pro  Ala Pro Thr 
    1805                 1810                 1815             


Asn Leu  Lys Phe Thr Gln Val  Thr Pro Thr Ser Leu  Thr Ala Gln 
    1820                 1825                 1830             


Trp Thr  Ala Pro Asn Val Gln  Leu Thr Gly Tyr Arg  Val Arg Val 
    1835                 1840                 1845             


Thr Pro  Lys Glu Lys Thr Gly  Pro Met Lys Glu Ile  Asn Leu Ala 
    1850                 1855                 1860             


Pro Asp  Ser Ser Ser Val Val  Val Ser Gly Leu Met  Val Ala Thr 
    1865                 1870                 1875             


Lys Tyr  Glu Val Ser Val Tyr  Ala Leu Lys Asp Thr  Leu Thr Ser 
    1880                 1885                 1890             


Arg Pro  Ala Gln Gly Val Val  Thr Thr Leu Glu Asn  Val Ser Pro 
    1895                 1900                 1905             


Pro Arg  Arg Ala Arg Val Thr  Asp Ala Thr Glu Thr  Thr Ile Thr 
    1910                 1915                 1920             


Ile Ser  Trp Arg Thr Lys Thr  Glu Thr Ile Thr Gly  Phe Gln Val 
    1925                 1930                 1935             


Asp Ala  Ile Pro Ala Asn Gly  Gln Thr Pro Ile Gln  Arg Thr Ile 
    1940                 1945                 1950             


Arg Pro  Asp Val Arg Ser Tyr  Thr Ile Thr Gly Leu  Gln Pro Gly 
    1955                 1960                 1965             


Thr Asp  Tyr Lys Ile His Leu  Tyr Thr Leu Asn Asp  Asn Ala Arg 
    1970                 1975                 1980             


Ser Ser  Pro Val Val Ile Asp  Ala Ser Thr Ala Ile  Asp Ala Pro 
    1985                 1990                 1995             


Ser Asn  Leu Arg Phe Leu Ala  Thr Thr Pro Asn Ser  Leu Leu Val 
    2000                 2005                 2010             


Ser Trp  Gln Pro Pro Arg Ala  Arg Ile Thr Gly Tyr  Ile Ile Lys 
    2015                 2020                 2025             


Tyr Glu  Lys Pro Gly Ser Pro  Pro Arg Glu Val Val  Pro Arg Pro 
    2030                 2035                 2040             


Arg Pro  Gly Val Thr Glu Ala  Thr Ile Thr Gly Leu  Glu Pro Gly 
    2045                 2050                 2055             


Thr Glu  Tyr Thr Ile Gln Val  Ile Ala Leu Lys Asn  Asn Gln Lys 
    2060                 2065                 2070             


Ser Glu  Pro Leu Ile Gly Arg  Lys Lys Thr Asp Glu  Leu Pro Gln 
    2075                 2080                 2085             


Leu Val  Thr Leu Pro His Pro  Asn Leu His Gly Pro  Glu Ile Leu 
    2090                 2095                 2100             


Asp Val  Pro Ser Thr Val Gln  Lys Thr Pro Phe Ile  Thr Asn Pro 
    2105                 2110                 2115             


Gly Tyr  Asp Thr Gly Asn Gly  Ile Gln Leu Pro Gly  Thr Ser Gly 
    2120                 2125                 2130             


Gln Gln  Pro Ser Leu Gly Gln  Gln Met Ile Phe Glu  Glu His Gly 
    2135                 2140                 2145             


Phe Arg  Arg Thr Thr Pro Pro  Thr Thr Ala Thr Pro  Val Arg His 
    2150                 2155                 2160             


Arg Pro  Arg Pro Tyr Pro Pro  Asn Val Asn Glu Glu  Ile Gln Ile 
    2165                 2170                 2175             


Gly His  Val Pro Arg Gly Asp  Val Asp His His Leu  Tyr Pro His 
    2180                 2185                 2190             


Val Val  Gly Leu Asn Pro Asn  Ala Ser Thr Gly Gln  Glu Ala Leu 
    2195                 2200                 2205             


Ser Gln  Thr Thr Ile Ser Trp  Thr Pro Phe Gln Glu  Ser Ser Glu 
    2210                 2215                 2220             


Tyr Ile  Ile Ser Cys His Pro  Val Gly Ile Asp Glu  Glu Pro Leu 
    2225                 2230                 2235             


Gln Phe  Arg Val Pro Gly Thr  Ser Ala Ser Ala Thr  Leu Thr Gly 
    2240                 2245                 2250             


Leu Thr  Arg Gly Ala Thr Tyr  Asn Ile Ile Val Glu  Ala Val Lys 
    2255                 2260                 2265             


Asp Gln  Gln Arg Gln Lys Val  Arg Glu Glu Val Val  Thr Val Gly 
    2270                 2275                 2280             


Asn Ser  Val Asp Gln Gly Leu  Ser Gln Pro Thr Asp  Asp Ser Cys 
    2285                 2290                 2295             


Phe Asp  Pro Tyr Thr Val Ser  His Tyr Ala Ile Gly  Glu Glu Trp 
    2300                 2305                 2310             


Glu Arg  Leu Ser Asp Ser Gly  Phe Lys Leu Ser Cys  Gln Cys Leu 
    2315                 2320                 2325             


Gly Phe  Gly Ser Gly His Phe  Arg Cys Asp Ser Ser  Lys Trp Cys 
    2330                 2335                 2340             


His Asp  Asn Gly Val Asn Tyr  Lys Ile Gly Glu Lys  Trp Asp Arg 
    2345                 2350                 2355             


Gln Gly  Glu Asn Gly Gln Met  Met Ser Cys Thr Cys  Leu Gly Asn 
    2360                 2365                 2370             


Gly Lys  Gly Glu Phe Lys Cys  Asp Pro His Glu Ala  Thr Cys Tyr 
    2375                 2380                 2385             


Asp Asp  Gly Lys Thr Tyr His  Val Gly Glu Gln Trp  Gln Lys Glu 
    2390                 2395                 2400             


Tyr Leu  Gly Ala Ile Cys Ser  Cys Thr Cys Phe Gly  Gly Gln Arg 
    2405                 2410                 2415             


Gly Trp  Arg Cys Asp Asn Cys  Arg Arg Pro Gly Ala  Glu Pro Gly 
    2420                 2425                 2430             


Asn Glu  Gly Ser Thr Ala His  Ser Tyr Asn Gln Tyr  Ser Gln Arg 
    2435                 2440                 2445             


Tyr His  Gln Arg Thr Asn Thr  Asn Val Asn Cys Pro  Ile Glu Cys 
    2450                 2455                 2460             


Phe Met  Pro Leu Asp Val Gln  Ala Asp Arg Glu Asp  Ser Arg Glu 
    2465                 2470                 2475             


<210>  2
<211>  3084
<212>  PRT
<213>  Mus musculus

<400>  2

Met Arg Gly Ser Gly Thr Gly Ala Ala Leu Leu Val Leu Leu Ala Ser 
1               5                   10                  15      


Val Leu Trp Val Thr Val Arg Ser Gln Gln Arg Gly Leu Phe Pro Ala 
            20                  25                  30          


Ile Leu Asn Leu Ala Thr Asn Ala His Ile Ser Ala Asn Ala Thr Cys 
        35                  40                  45              


Gly Glu Lys Gly Pro Glu Met Phe Cys Lys Leu Val Glu His Val Pro 
    50                  55                  60                  


Gly Arg Pro Val Arg His Ala Gln Cys Arg Val Cys Asp Gly Asn Ser 
65                  70                  75                  80  


Thr Asn Pro Arg Glu Arg His Pro Ile Ser His Ala Ile Asp Gly Thr 
                85                  90                  95      


Asn Asn Trp Trp Gln Ser Pro Ser Ile Gln Asn Gly Arg Glu Tyr His 
            100                 105                 110         


Trp Val Thr Val Thr Leu Asp Leu Arg Gln Val Phe Gln Val Ala Tyr 
        115                 120                 125             


Ile Ile Ile Lys Ala Ala Asn Ala Pro Arg Pro Gly Asn Trp Ile Leu 
    130                 135                 140                 


Glu Arg Ser Val Asp Gly Val Lys Phe Lys Pro Trp Gln Tyr Tyr Ala 
145                 150                 155                 160 


Val Ser Asp Thr Glu Cys Leu Thr Arg Tyr Lys Ile Thr Pro Arg Arg 
                165                 170                 175     


Gly Pro Pro Thr Tyr Arg Ala Asp Asn Glu Val Ile Cys Thr Ser Tyr 
            180                 185                 190         


Tyr Ser Lys Leu Val Pro Leu Glu His Gly Glu Ile His Thr Ser Leu 
        195                 200                 205             


Ile Asn Gly Arg Pro Ser Ala Asp Asp Pro Ser Pro Gln Leu Leu Glu 
    210                 215                 220                 


Phe Thr Ser Ala Arg Tyr Ile Arg Leu Arg Leu Gln Arg Ile Arg Thr 
225                 230                 235                 240 


Leu Asn Ala Asp Leu Met Thr Leu Ser His Arg Asp Leu Arg Asp Leu 
                245                 250                 255     


Asp Pro Ile Val Thr Arg Arg Tyr Tyr Tyr Ser Ile Lys Asp Ile Ser 
            260                 265                 270         


Val Gly Gly Met Cys Ile Cys Tyr Gly His Ala Ser Ser Cys Pro Trp 
        275                 280                 285             


Asp Glu Glu Ala Lys Gln Leu Gln Cys Gln Cys Glu His Asn Thr Cys 
    290                 295                 300                 


Gly Glu Ser Cys Asp Arg Cys Cys Pro Gly Tyr His Gln Gln Pro Trp 
305                 310                 315                 320 


Arg Pro Gly Thr Ile Ser Ser Gly Asn Glu Cys Glu Glu Cys Asn Cys 
                325                 330                 335     


His Asn Lys Ala Lys Asp Cys Tyr Tyr Asp Ser Ser Val Ala Lys Glu 
            340                 345                 350         


Arg Arg Ser Leu Asn Thr Ala Gly Gln Tyr Ser Gly Gly Gly Val Cys 
        355                 360                 365             


Val Asn Cys Ser Gln Asn Thr Thr Gly Ile Asn Cys Glu Thr Cys Ile 
    370                 375                 380                 


Asp Gln Tyr Tyr Arg Pro His Lys Val Ser Pro Tyr Asp Asp His Pro 
385                 390                 395                 400 


Cys Arg Pro Cys Asn Cys Asp Pro Val Gly Ser Leu Ser Ser Val Cys 
                405                 410                 415     


Ile Lys Asp Asp Arg His Ala Asp Leu Ala Asn Gly Lys Trp Pro Gly 
            420                 425                 430         


Gln Cys Pro Cys Arg Lys Gly Tyr Ala Gly Asp Lys Cys Asp Arg Cys 
        435                 440                 445             


Gln Phe Gly Tyr Arg Gly Phe Pro Asn Cys Ile Pro Cys Asp Cys Arg 
    450                 455                 460                 


Thr Val Gly Ser Leu Asn Glu Asp Pro Cys Ile Glu Pro Cys Leu Cys 
465                 470                 475                 480 


Lys Lys Asn Val Glu Gly Lys Asn Cys Asp Arg Cys Lys Pro Gly Phe 
                485                 490                 495     


Tyr Asn Leu Lys Glu Arg Asn Pro Glu Gly Cys Ser Glu Cys Phe Cys 
            500                 505                 510         


Phe Gly Val Ser Gly Val Cys Asp Ser Leu Thr Trp Ser Ile Ser Gln 
        515                 520                 525             


Val Thr Asn Met Ser Gly Trp Leu Val Thr Asp Leu Met Ser Thr Asn 
    530                 535                 540                 


Lys Ile Arg Ser Gln Gln Asp Val Leu Gly Gly His Arg Gln Ile Ser 
545                 550                 555                 560 


Ile Asn Asn Thr Ala Val Met Gln Arg Leu Thr Ser Thr Tyr Tyr Trp 
                565                 570                 575     


Ala Ala Pro Glu Ala Tyr Leu Gly Asn Lys Leu Thr Ala Phe Gly Gly 
            580                 585                 590         


Phe Leu Lys Tyr Thr Val Ser Tyr Asp Ile Pro Val Glu Thr Val Asp 
        595                 600                 605             


Ser Asp Leu Met Ser His Ala Asp Ile Ile Ile Lys Gly Asn Gly Leu 
    610                 615                 620                 


Thr Ile Ser Thr Arg Ala Glu Gly Leu Ser Leu Gln Pro Tyr Glu Glu 
625                 630                 635                 640 


Tyr Phe Asn Val Val Arg Leu Val Pro Glu Asn Phe Arg Asp Phe Asn 
                645                 650                 655     


Thr Arg Arg Glu Ile Asp Arg Asp Gln Leu Met Thr Val Leu Ala Asn 
            660                 665                 670         


Val Thr His Leu Leu Ile Arg Ala Asn Tyr Asn Ser Ala Lys Met Ala 
        675                 680                 685             


Leu Tyr Arg Leu Asp Ser Val Ser Leu Asp Ile Ala Ser Pro Asn Ala 
    690                 695                 700                 


Ile Asp Leu Ala Val Ala Ala Asp Val Glu His Cys Glu Cys Pro Gln 
705                 710                 715                 720 


Gly Tyr Thr Gly Thr Ser Cys Glu Ala Cys Leu Pro Gly Tyr Tyr Arg 
                725                 730                 735     


Val Asp Gly Ile Leu Phe Gly Gly Ile Cys Gln Pro Cys Glu Cys His 
            740                 745                 750         


Gly His Ala Ser Glu Cys Asp Ile His Gly Ile Cys Ser Val Cys Thr 
        755                 760                 765             


His Asn Thr Thr Gly Asp His Cys Glu Gln Cys Leu Pro Gly Phe Tyr 
    770                 775                 780                 


Gly Thr Pro Ser Arg Gly Thr Pro Gly Asp Cys Gln Pro Cys Ala Cys 
785                 790                 795                 800 


Pro Leu Ser Ile Asp Ser Asn Asn Phe Ser Pro Thr Cys His Leu Thr 
                805                 810                 815     


Asp Gly Glu Glu Val Val Cys Asp Gln Cys Ala Pro Gly Tyr Ser Gly 
            820                 825                 830         


Ser Trp Cys Glu Arg Cys Ala Asp Gly Tyr Tyr Gly Asn Pro Thr Val 
        835                 840                 845             


Pro Gly Gly Thr Cys Val Pro Cys Asn Cys Ser Gly Asn Val Asp Pro 
    850                 855                 860                 


Leu Glu Ala Gly His Cys Asp Ser Val Thr Gly Glu Cys Leu Lys Cys 
865                 870                 875                 880 


Leu Trp Asn Thr Asp Gly Ala His Cys Glu Arg Cys Ala Asp Gly Phe 
                885                 890                 895     


Tyr Gly Asp Ala Val Thr Ala Lys Asn Cys Arg Ala Cys Asp Cys His 
            900                 905                 910         


Glu Asn Gly Ser Leu Ser Gly Val Cys His Leu Glu Thr Gly Leu Cys 
        915                 920                 925             


Asp Cys Lys Pro His Val Thr Gly Gln Gln Cys Asp Gln Cys Leu Ser 
    930                 935                 940                 


Gly Tyr Tyr Gly Leu Asp Thr Gly Leu Gly Cys Val Pro Cys Asn Cys 
945                 950                 955                 960 


Ser Val Glu Gly Ser Val Ser Asp Asn Cys Thr Glu Glu Gly Gln Cys 
                965                 970                 975     


His Cys Gly Pro Gly Val Ser Gly Lys Gln Cys Asp Arg Cys Ser His 
            980                 985                 990         


Gly Phe Tyr Ala Phe Gln Asp Gly  Gly Cys Thr Pro Cys  Asp Cys Ala 
        995                 1000                 1005             


His Thr  Gln Asn Asn Cys Asp  Pro Ala Ser Gly Glu  Cys Leu Cys 
    1010                 1015                 1020             


Pro Pro  His Thr Gln Gly Leu  Lys Cys Glu Glu Cys  Glu Glu Ala 
    1025                 1030                 1035             


Tyr Trp  Gly Leu Asp Pro Glu  Gln Gly Cys Gln Ala  Cys Asn Cys 
    1040                 1045                 1050             


Ser Ala  Val Gly Ser Thr Ser  Ala Gln Cys Asp Val  Leu Ser Gly 
    1055                 1060                 1065             


His Cys  Pro Cys Lys Lys Gly  Phe Gly Gly Gln Ser  Cys His Gln 
    1070                 1075                 1080             


Cys Ser  Leu Gly Tyr Arg Ser  Phe Pro Asp Cys Val  Pro Cys Gly 
    1085                 1090                 1095             


Cys Asp  Leu Arg Gly Thr Leu  Pro Asp Thr Cys Asp  Leu Glu Gln 
    1100                 1105                 1110             


Gly Leu  Cys Ser Cys Ser Glu  Asp Ser Gly Thr Cys  Ser Cys Lys 
    1115                 1120                 1125             


Glu Asn  Val Val Gly Pro Gln  Cys Ser Lys Cys Gln  Ala Gly Thr 
    1130                 1135                 1140             


Phe Ala  Leu Arg Gly Asp Asn  Pro Gln Gly Cys Ser  Pro Cys Phe 
    1145                 1150                 1155             


Cys Phe  Gly Leu Ser Gln Leu  Cys Ser Glu Leu Glu  Gly Tyr Val 
    1160                 1165                 1170             


Arg Thr  Leu Ile Thr Leu Ala  Ser Asp Gln Pro Leu  Leu His Val 
    1175                 1180                 1185             


Val Ser  Gln Ser Asn Leu Lys  Gly Thr Ile Glu Gly  Val His Phe 
    1190                 1195                 1200             


Gln Pro  Pro Asp Thr Leu Leu  Asp Ala Glu Ala Val  Arg Gln His 
    1205                 1210                 1215             


Ile Tyr  Ala Glu Pro Phe Tyr  Trp Arg Leu Pro Lys  Gln Phe Gln 
    1220                 1225                 1230             


Gly Asp  Gln Leu Leu Ala Tyr  Gly Gly Lys Leu Gln  Tyr Ser Val 
    1235                 1240                 1245             


Ala Phe  Tyr Ser Thr Leu Gly  Thr Gly Thr Ser Asn  Tyr Glu Pro 
    1250                 1255                 1260             


Gln Val  Leu Ile Lys Gly Gly  Arg Ala Arg Lys His  Val Ile Tyr 
    1265                 1270                 1275             


Met Asp  Ala Pro Ala Pro Glu  Asn Gly Val Arg Gln  Asp Tyr Glu 
    1280                 1285                 1290             


Val Gln  Met Lys Glu Glu Phe  Trp Lys Tyr Phe Asn  Ser Val Ser 
    1295                 1300                 1305             


Glu Lys  His Val Thr His Ser  Asp Phe Met Ser Val  Leu Ser Asn 
    1310                 1315                 1320             


Ile Asp  Tyr Ile Leu Ile Lys  Ala Ser Tyr Gly Gln  Gly Leu Gln 
    1325                 1330                 1335             


Gln Ser  Arg Ile Ala Asn Ile  Ser Met Glu Val Gly  Arg Lys Ala 
    1340                 1345                 1350             


Val Glu  Leu Pro Ala Glu Gly  Glu Ala Ala Leu Leu  Leu Glu Leu 
    1355                 1360                 1365             


Cys Val  Cys Pro Pro Gly Thr  Ala Gly His Ser Cys  Gln Asp Cys 
    1370                 1375                 1380             


Ala Pro  Gly Tyr Tyr Arg Glu  Lys Leu Pro Glu Ser  Gly Gly Arg 
    1385                 1390                 1395             


Gly Pro  Arg Pro Leu Leu Ala  Pro Cys Val Pro Cys  Asn Cys Asn 
    1400                 1405                 1410             


Asn His  Ser Asp Val Cys Asp  Pro Glu Thr Gly Lys  Cys Leu Ser 
    1415                 1420                 1425             


Cys Arg  Asp His Thr Ser Gly  Asp His Cys Glu Leu  Cys Ala Ser 
    1430                 1435                 1440             


Gly Tyr  Tyr Gly Lys Val Thr  Gly Leu Pro Gly Asp  Cys Thr Pro 
    1445                 1450                 1455             


Cys Thr  Cys Pro His His Pro  Pro Phe Ser Phe Ser  Pro Thr Cys 
    1460                 1465                 1470             


Val Val  Glu Gly Asp Ser Asp  Phe Arg Cys Asn Ala  Cys Leu Pro 
    1475                 1480                 1485             


Gly Tyr  Glu Gly Gln Tyr Cys  Glu Arg Cys Ser Ala  Gly Tyr His 
    1490                 1495                 1500             


Gly Asn  Pro Arg Ala Ala Gly  Gly Ser Cys Gln Thr  Cys Asp Cys 
    1505                 1510                 1515             


Asn Pro  Gln Gly Ser Val His  Ser Asp Cys Asp Arg  Ala Ser Gly 
    1520                 1525                 1530             


Gln Cys  Val Cys Lys Pro Gly  Ala Thr Gly Leu His  Cys Glu Lys 
    1535                 1540                 1545             


Cys Leu  Pro Arg His Ile Leu  Met Glu Ser Asp Cys  Val Ser Cys 
    1550                 1555                 1560             


Asp Asp  Asp Cys Val Gly Pro  Leu Leu Asn Asp Leu  Asp Ser Val 
    1565                 1570                 1575             


Gly Asp  Ala Val Leu Ser Leu  Asn Leu Thr Gly Val  Ser Pro Ala 
    1580                 1585                 1590             


Pro Tyr  Gly Ile Leu Glu Asn  Leu Glu Asn Thr Thr  Lys Tyr Phe 
    1595                 1600                 1605             


Gln Arg  Tyr Leu Ile Lys Glu  Asn Ala Lys Lys Ile  Arg Ala Glu 
    1610                 1615                 1620             


Ile Gln  Leu Glu Gly Ile Ala  Glu Gln Thr Glu Asn  Leu Gln Lys 
    1625                 1630                 1635             


Glu Leu  Thr Arg Val Leu Ala  Arg His Gln Lys Val  Asn Ala Glu 
    1640                 1645                 1650             


Met Glu  Arg Thr Ser Asn Gly  Thr Gln Ala Leu Ala  Thr Phe Ile 
    1655                 1660                 1665             


Glu Gln  Leu His Ala Asn Ile  Lys Glu Ile Thr Glu  Lys Val Ala 
    1670                 1675                 1680             


Thr Leu  Asn Gln Thr Ala Arg  Lys Asp Phe Gln Pro  Pro Val Ser 
    1685                 1690                 1695             


Ala Leu  Gln Ser Met His Gln  Asn Ile Ser Ser Leu  Leu Gly Leu 
    1700                 1705                 1710             


Ile Lys  Glu Arg Asn Phe Thr  Glu Met Gln Gln Asn  Ala Thr Leu 
    1715                 1720                 1725             


Glu Leu  Lys Ala Ala Lys Asp  Leu Leu Ser Arg Ile  Gln Lys Arg 
    1730                 1735                 1740             


Phe Gln  Lys Pro Gln Glu Lys  Leu Lys Ala Leu Lys  Glu Ala Asn 
    1745                 1750                 1755             


Ser Leu  Leu Ser Asn His Ser  Glu Lys Leu Gln Ala  Ala Glu Glu 
    1760                 1765                 1770             


Leu Leu  Lys Glu Ala Gly Ser  Lys Thr Gln Glu Ser  Asn Leu Leu 
    1775                 1780                 1785             


Leu Leu  Leu Val Lys Ala Asn  Leu Lys Glu Glu Phe  Gln Glu Lys 
    1790                 1795                 1800             


Lys Leu  Arg Val Gln Glu Glu  Gln Asn Val Thr Ser  Glu Leu Ile 
    1805                 1810                 1815             


Ala Lys  Gly Arg Glu Trp Val  Asp Ala Ala Gly Thr  His Thr Ala 
    1820                 1825                 1830             


Ala Ala  Gln Asp Thr Leu Thr  Gln Leu Glu His His  Arg Asp Glu 
    1835                 1840                 1845             


Leu Leu  Leu Trp Ala Arg Lys  Ile Arg Ser His Val  Asp Asp Leu 
    1850                 1855                 1860             


Val Met  Gln Met Ser Lys Arg  Arg Ala Arg Asp Leu  Val His Arg 
    1865                 1870                 1875             


Ala Glu  Gln His Ala Ser Glu  Leu Gln Ser Arg Ala  Gly Ala Leu 
    1880                 1885                 1890             


Asp Arg  Asp Leu Glu Asn Val  Arg Asn Val Ser Leu  Asn Ala Thr 
    1895                 1900                 1905             


Ser Ala  Ala His Val His Ser  Asn Ile Gln Thr Leu  Thr Glu Glu 
    1910                 1915                 1920             


Ala Glu  Met Leu Ala Ala Asp  Ala His Lys Thr Ala  Asn Lys Thr 
    1925                 1930                 1935             


Asp Leu  Ile Ser Glu Ser Leu  Ala Ser Arg Gly Lys  Ala Val Leu 
    1940                 1945                 1950             


Gln Arg  Ser Ser Arg Phe Leu  Lys Glu Ser Val Gly  Thr Arg Arg 
    1955                 1960                 1965             


Lys Gln  Gln Gly Ile Thr Met  Lys Leu Asp Glu Leu  Lys Asn Leu 
    1970                 1975                 1980             


Thr Ser  Gln Phe Gln Glu Ser  Val Asp Asn Ile Thr  Lys Gln Ala 
    1985                 1990                 1995             


Asn Asp  Ser Leu Ala Met Leu  Arg Glu Ser Pro Gly  Gly Met Arg 
    2000                 2005                 2010             


Glu Lys  Gly Arg Lys Ala Arg  Glu Leu Ala Ala Ala  Ala Asn Glu 
    2015                 2020                 2025             


Ser Ala  Val Lys Thr Leu Glu  Asp Val Leu Ala Leu  Ser Leu Arg 
    2030                 2035                 2040             


Val Phe  Asn Thr Ser Glu Asp  Leu Ser Arg Val Asn  Ala Thr Val 
    2045                 2050                 2055             


Gln Glu  Thr Asn Asp Leu Leu  His Asn Ser Thr Met  Thr Thr Leu 
    2060                 2065                 2070             


Leu Ala  Gly Arg Lys Met Lys  Asp Met Glu Met Gln  Ala Asn Leu 
    2075                 2080                 2085             


Leu Leu  Asp Arg Leu Lys Pro  Leu Lys Thr Leu Glu  Glu Asn Leu 
    2090                 2095                 2100             


Ser Arg  Asn Leu Ser Glu Ile  Lys Leu Leu Ile Ser  Arg Ala Arg 
    2105                 2110                 2115             


Lys Gln  Ala Ala Ser Ile Lys  Val Ala Val Ser Ala  Asp Arg Asp 
    2120                 2125                 2130             


Cys Ile  Arg Ala Tyr Gln Pro  Gln Thr Ser Ser Thr  Asn Tyr Asn 
    2135                 2140                 2145             


Thr Leu  Ile Leu Asn Val Lys  Thr Gln Glu Pro Asp  Asn Leu Leu 
    2150                 2155                 2160             


Phe Tyr  Leu Gly Ser Ser Ser  Ser Ser Asp Phe Leu  Ala Val Glu 
    2165                 2170                 2175             


Met Arg  Arg Gly Lys Val Ala  Phe Leu Trp Asp Leu  Gly Ser Gly 
    2180                 2185                 2190             


Ser Thr  Arg Leu Glu Phe Pro  Glu Val Ser Ile Asn  Asn Asn Arg 
    2195                 2200                 2205             


Trp His  Ser Ile Tyr Ile Thr  Arg Phe Gly Asn Met  Gly Ser Leu 
    2210                 2215                 2220             


Ser Val  Lys Glu Ala Ser Ala  Ala Glu Asn Pro Pro  Val Arg Thr 
    2225                 2230                 2235             


Ser Lys  Ser Pro Gly Pro Ser  Lys Val Leu Asp Ile  Asn Asn Ser 
    2240                 2245                 2250             


Thr Leu  Met Phe Val Gly Gly  Leu Gly Gly Gln Ile  Lys Lys Ser 
    2255                 2260                 2265             


Pro Ala  Val Lys Val Thr His  Phe Lys Gly Cys Met  Gly Glu Ala 
    2270                 2275                 2280             


Phe Leu  Asn Gly Lys Ser Ile  Gly Leu Trp Asn Tyr  Ile Glu Arg 
    2285                 2290                 2295             


Glu Gly  Lys Cys Asn Gly Cys  Phe Gly Ser Ser Gln  Asn Glu Asp 
    2300                 2305                 2310             


Ser Ser  Phe His Phe Asp Gly  Ser Gly Tyr Ala Met  Val Glu Lys 
    2315                 2320                 2325             


Thr Leu  Arg Pro Thr Val Thr  Gln Ile Val Ile Leu  Phe Ser Thr 
    2330                 2335                 2340             


Phe Ser  Pro Asn Gly Leu Leu  Phe Tyr Leu Ala Ser  Asn Gly Thr 
    2345                 2350                 2355             


Lys Asp  Phe Leu Ser Ile Glu  Leu Val Arg Gly Arg  Val Lys Val 
    2360                 2365                 2370             


Met Val  Asp Leu Gly Ser Gly  Pro Leu Thr Leu Met  Thr Asp Arg 
    2375                 2380                 2385             


Arg Tyr  Asn Asn Gly Thr Trp  Tyr Lys Ile Ala Phe  Gln Arg Asn 
    2390                 2395                 2400             


Arg Lys  Gln Gly Leu Leu Ala  Val Phe Asp Ala Tyr  Asp Thr Ser 
    2405                 2410                 2415             


Asp Lys  Glu Thr Lys Gln Gly  Glu Thr Pro Gly Ala  Ala Ser Asp 
    2420                 2425                 2430             


Leu Asn  Arg Leu Glu Lys Asp  Leu Ile Tyr Val Gly  Gly Leu Pro 
    2435                 2440                 2445             


His Ser  Lys Ala Val Arg Lys  Gly Val Ser Ser Arg  Ser Tyr Val 
    2450                 2455                 2460             


Gly Cys  Ile Lys Asn Leu Glu  Ile Ser Arg Ser Thr  Phe Asp Leu 
    2465                 2470                 2475             


Leu Arg  Asn Ser Tyr Gly Val  Arg Lys Gly Cys Ala  Leu Glu Pro 
    2480                 2485                 2490             


Ile Gln  Ser Val Ser Phe Leu  Arg Gly Gly Tyr Val  Glu Met Pro 
    2495                 2500                 2505             


Pro Lys  Ser Leu Ser Pro Glu  Ser Ser Leu Leu Ala  Thr Phe Ala 
    2510                 2515                 2520             


Thr Lys  Asn Ser Ser Gly Ile  Leu Leu Val Ala Leu  Gly Lys Asp 
    2525                 2530                 2535             


Ala Glu  Glu Ala Gly Gly Ala  Gln Ala His Val Pro  Phe Phe Ser 
    2540                 2545                 2550             


Ile Met  Leu Leu Glu Gly Arg  Ile Glu Val His Val  Asn Ser Gly 
    2555                 2560                 2565             


Asp Gly  Thr Ser Leu Arg Lys  Ala Leu Leu His Ala  Pro Thr Gly 
    2570                 2575                 2580             


Ser Tyr  Ser Asp Gly Gln Glu  His Ser Ile Ser Leu  Val Arg Asn 
    2585                 2590                 2595             


Arg Arg  Val Ile Thr Ile Gln  Val Asp Glu Asn Ser  Pro Val Glu 
    2600                 2605                 2610             


Met Lys  Leu Gly Pro Leu Thr  Glu Gly Lys Thr Ile  Asp Ile Ser 
    2615                 2620                 2625             


Asn Leu  Tyr Ile Gly Gly Leu  Pro Glu Asp Lys Ala  Thr Pro Met 
    2630                 2635                 2640             


Leu Lys  Met Arg Thr Ser Phe  His Gly Cys Ile Lys  Asn Val Val 
    2645                 2650                 2655             


Leu Asp  Ala Gln Leu Leu Asp  Phe Thr His Ala Thr  Gly Ser Glu 
    2660                 2665                 2670             


Gln Val  Glu Leu Asp Thr Cys  Leu Leu Ala Glu Glu  Pro Met Gln 
    2675                 2680                 2685             


Ser Leu  His Arg Glu His Gly  Glu Leu Pro Pro Glu  Pro Pro Thr 
    2690                 2695                 2700             


Leu Pro  Gln Pro Glu Leu Cys  Ala Val Asp Thr Ala  Pro Gly Tyr 
    2705                 2710                 2715             


Val Ala  Gly Ala His Gln Phe  Gly Leu Ser Gln Asn  Ser His Leu 
    2720                 2725                 2730             


Val Leu  Pro Leu Asn Gln Ser  Asp Val Arg Lys Arg  Leu Gln Val 
    2735                 2740                 2745             


Gln Leu  Ser Ile Arg Thr Phe  Ala Ser Ser Gly Leu  Ile Tyr Tyr 
    2750                 2755                 2760             


Val Ala  His Gln Asn Gln Met  Asp Tyr Ala Thr Leu  Gln Leu Gln 
    2765                 2770                 2775             


Glu Gly  Arg Leu His Phe Met  Phe Asp Leu Gly Lys  Gly Arg Thr 
    2780                 2785                 2790             


Lys Val  Ser His Pro Ala Leu  Leu Ser Asp Gly Lys  Trp His Thr 
    2795                 2800                 2805             


Val Lys  Thr Glu Tyr Ile Lys  Arg Lys Ala Phe Met  Thr Val Asp 
    2810                 2815                 2820             


Gly Gln  Glu Ser Pro Ser Val  Thr Val Val Gly Asn  Ala Thr Thr 
    2825                 2830                 2835             


Leu Asp  Val Glu Arg Lys Leu  Tyr Leu Gly Gly Leu  Pro Ser His 
    2840                 2845                 2850             


Tyr Arg  Ala Arg Asn Ile Gly  Thr Ile Thr His Ser  Ile Pro Ala 
    2855                 2860                 2865             


Cys Ile  Gly Glu Ile Met Val  Asn Gly Gln Gln Leu  Asp Lys Asp 
    2870                 2875                 2880             


Arg Pro  Leu Ser Ala Ser Ala  Val Asp Arg Cys Tyr  Val Val Ala 
    2885                 2890                 2895             


Gln Glu  Gly Thr Phe Phe Glu  Gly Ser Gly Tyr Ala  Ala Leu Val 
    2900                 2905                 2910             


Lys Glu  Gly Tyr Lys Val Arg  Leu Asp Leu Asn Ile  Thr Leu Glu 
    2915                 2920                 2925             


Phe Arg  Thr Thr Ser Lys Asn  Gly Val Leu Leu Gly  Ile Ser Ser 
    2930                 2935                 2940             


Ala Lys  Val Asp Ala Ile Gly  Leu Glu Ile Val Asp  Gly Lys Val 
    2945                 2950                 2955             


Leu Phe  His Val Asn Asn Gly  Ala Gly Arg Ile Thr  Ala Thr Tyr 
    2960                 2965                 2970             


Gln Pro  Arg Ala Ala Arg Ala  Leu Cys Asp Gly Lys  Trp His Thr 
    2975                 2980                 2985             


Leu Gln  Ala His Lys Ser Lys  His Arg Ile Val Leu  Thr Val Asp 
    2990                 2995                 3000             


Gly Asn  Ser Val Arg Ala Glu  Ser Pro His Thr His  Ser Thr Ser 
    3005                 3010                 3015             


Ala Asp  Thr Asn Asp Pro Ile  Tyr Val Gly Gly Tyr  Pro Ala His 
    3020                 3025                 3030             


Ile Lys  Gln Asn Cys Leu Ser  Ser Arg Ala Ser Phe  Arg Gly Cys 
    3035                 3040                 3045             


Val Arg  Asn Leu Arg Leu Ser  Arg Gly Ser Gln Val  Gln Ser Leu 
    3050                 3055                 3060             


Asp Leu  Ser Arg Ala Phe Asp  Leu Gln Gly Val Phe  Pro His Ser 
    3065                 3070                 3075             


Cys Pro  Gly Pro Glu Pro 
    3080                 


<210>  3
<211>  1786
<212>  PRT
<213>  Mus musculus

<400>  3

Met Gly Leu Leu Gln Val Phe Ala Phe Gly Val Leu Ala Leu Trp Gly 
1               5                   10                  15      


Thr Arg Val Cys Ala Gln Glu Pro Glu Phe Ser Tyr Gly Cys Ala Glu 
            20                  25                  30          


Gly Ser Cys Tyr Pro Ala Thr Gly Asp Leu Leu Ile Gly Arg Ala Gln 
        35                  40                  45              


Lys Leu Ser Val Thr Ser Thr Cys Gly Leu His Lys Pro Glu Pro Tyr 
    50                  55                  60                  


Cys Ile Val Ser His Leu Gln Glu Asp Lys Lys Cys Phe Ile Cys Asp 
65                  70                  75                  80  


Ser Arg Asp Pro Tyr His Glu Thr Leu Asn Pro Asp Ser His Leu Ile 
                85                  90                  95      


Glu Asn Val Val Thr Thr Phe Ala Pro Asn Arg Leu Lys Ile Trp Trp 
            100                 105                 110         


Gln Ser Glu Asn Gly Val Glu Asn Val Thr Ile Gln Leu Asp Leu Glu 
        115                 120                 125             


Ala Glu Phe His Phe Thr His Leu Ile Met Thr Phe Lys Thr Phe Arg 
    130                 135                 140                 


Pro Ala Ala Met Leu Ile Glu Arg Ser Ser Asp Phe Gly Lys Ala Trp 
145                 150                 155                 160 


Gly Val Tyr Arg Tyr Phe Ala Tyr Asp Cys Glu Ser Ser Phe Pro Gly 
                165                 170                 175     


Ile Ser Thr Gly Pro Met Lys Lys Val Asp Asp Ile Ile Cys Asp Ser 
            180                 185                 190         


Arg Tyr Ser Asp Ile Glu Pro Ser Thr Glu Gly Glu Val Ile Phe Arg 
        195                 200                 205             


Ala Leu Asp Pro Ala Phe Lys Ile Glu Asp Pro Tyr Ser Pro Arg Ile 
    210                 215                 220                 


Gln Asn Leu Leu Lys Ile Thr Asn Leu Arg Ile Lys Phe Val Lys Leu 
225                 230                 235                 240 


His Thr Leu Gly Asp Asn Leu Leu Asp Ser Arg Met Glu Ile Arg Glu 
                245                 250                 255     


Lys Tyr Tyr Tyr Ala Val Tyr Asp Met Val Val Arg Gly Asn Cys Phe 
            260                 265                 270         


Cys Tyr Gly His Ala Ser Glu Cys Ala Pro Val Asp Gly Val Asn Glu 
        275                 280                 285             


Glu Val Glu Gly Met Val His Gly His Cys Met Cys Arg His Asn Thr 
    290                 295                 300                 


Lys Gly Leu Asn Cys Glu Leu Cys Met Asp Phe Tyr His Asp Leu Pro 
305                 310                 315                 320 


Trp Arg Pro Ala Glu Gly Arg Asn Ser Asn Ala Cys Lys Lys Cys Asn 
                325                 330                 335     


Cys Asn Glu His Ser Ser Ser Cys His Phe Asp Met Ala Val Phe Leu 
            340                 345                 350         


Ala Thr Gly Asn Val Ser Gly Gly Val Cys Asp Asn Cys Gln His Asn 
        355                 360                 365             


Thr Met Gly Arg Asn Cys Glu Gln Cys Lys Pro Phe Tyr Phe Gln His 
    370                 375                 380                 


Pro Glu Arg Asp Ile Arg Asp Pro Asn Leu Cys Glu Pro Cys Thr Cys 
385                 390                 395                 400 


Asp Pro Ala Gly Ser Glu Asn Gly Gly Ile Cys Asp Gly Tyr Thr Asp 
                405                 410                 415     


Phe Ser Val Gly Leu Ile Ala Gly Gln Cys Arg Cys Lys Leu His Val 
            420                 425                 430         


Glu Gly Glu Arg Cys Asp Val Cys Lys Glu Gly Phe Tyr Asp Leu Ser 
        435                 440                 445             


Ala Glu Asp Pro Tyr Gly Cys Lys Ser Cys Ala Cys Asn Pro Leu Gly 
    450                 455                 460                 


Thr Ile Pro Gly Gly Asn Pro Cys Asp Ser Glu Thr Gly Tyr Cys Tyr 
465                 470                 475                 480 


Cys Lys Arg Leu Val Thr Gly Gln Arg Cys Asp Gln Cys Leu Pro Gln 
                485                 490                 495     


His Trp Gly Leu Ser Asn Asp Leu Asp Gly Cys Arg Pro Cys Asp Cys 
            500                 505                 510         


Asp Leu Gly Gly Ala Leu Asn Asn Ser Cys Ser Glu Asp Ser Gly Gln 
        515                 520                 525             


Cys Ser Cys Leu Pro His Met Ile Gly Arg Gln Cys Asn Glu Val Glu 
    530                 535                 540                 


Ser Gly Tyr Tyr Phe Thr Thr Leu Asp His Tyr Ile Tyr Glu Ala Glu 
545                 550                 555                 560 


Glu Ala Asn Leu Gly Pro Gly Val Ile Val Val Glu Arg Gln Tyr Ile 
                565                 570                 575     


Gln Asp Arg Ile Pro Ser Trp Thr Gly Pro Gly Phe Val Arg Val Pro 
            580                 585                 590         


Glu Gly Ala Tyr Leu Glu Phe Phe Ile Asp Asn Ile Pro Tyr Ser Met 
        595                 600                 605             


Glu Tyr Glu Ile Leu Ile Arg Tyr Glu Pro Gln Leu Pro Asp His Trp 
    610                 615                 620                 


Glu Lys Ala Val Ile Thr Val Gln Arg Pro Gly Lys Ile Pro Ala Ser 
625                 630                 635                 640 


Ser Arg Cys Gly Asn Thr Val Pro Asp Asp Asp Asn Gln Val Val Ser 
                645                 650                 655     


Leu Ser Pro Gly Ser Arg Tyr Val Val Leu Pro Arg Pro Val Cys Phe 
            660                 665                 670         


Glu Lys Gly Met Asn Tyr Thr Val Arg Leu Glu Leu Pro Gln Tyr Thr 
        675                 680                 685             


Ala Ser Gly Ser Asp Val Glu Ser Pro Tyr Thr Phe Ile Asp Ser Leu 
    690                 695                 700                 


Val Leu Met Pro Tyr Cys Lys Ser Leu Asp Ile Phe Thr Val Gly Gly 
705                 710                 715                 720 


Ser Gly Asp Gly Glu Val Thr Asn Ser Ala Trp Glu Thr Phe Gln Arg 
                725                 730                 735     


Tyr Arg Cys Leu Glu Asn Ser Arg Ser Val Val Lys Thr Pro Met Thr 
            740                 745                 750         


Asp Val Cys Arg Asn Ile Ile Phe Ser Ile Ser Ala Leu Ile His Gln 
        755                 760                 765             


Thr Gly Leu Ala Cys Glu Cys Asp Pro Gln Gly Ser Leu Ser Ser Val 
    770                 775                 780                 


Cys Asp Pro Asn Gly Gly Gln Cys Gln Cys Arg Pro Asn Val Val Gly 
785                 790                 795                 800 


Arg Thr Cys Asn Arg Cys Ala Pro Gly Thr Phe Gly Phe Gly Pro Asn 
                805                 810                 815     


Gly Cys Lys Pro Cys Asp Cys His Leu Gln Gly Ser Ala Ser Ala Phe 
            820                 825                 830         


Cys Asp Ala Ile Thr Gly Gln Cys His Cys Phe Gln Gly Ile Tyr Ala 
        835                 840                 845             


Arg Gln Cys Asp Arg Cys Leu Pro Gly Tyr Trp Gly Phe Pro Ser Cys 
    850                 855                 860                 


Gln Pro Cys Gln Cys Asn Gly His Ala Leu Asp Cys Asp Thr Val Thr 
865                 870                 875                 880 


Gly Glu Cys Leu Ser Cys Gln Asp Tyr Thr Thr Gly His Asn Cys Glu 
                885                 890                 895     


Arg Cys Leu Ala Gly Tyr Tyr Gly Asp Pro Ile Ile Gly Ser Gly Asp 
            900                 905                 910         


His Cys Arg Pro Cys Pro Cys Pro Asp Gly Pro Asp Ser Gly Arg Gln 
        915                 920                 925             


Phe Ala Arg Ser Cys Tyr Gln Asp Pro Val Thr Leu Gln Leu Ala Cys 
    930                 935                 940                 


Val Cys Asp Pro Gly Tyr Ile Gly Ser Arg Cys Asp Asp Cys Ala Ser 
945                 950                 955                 960 


Gly Phe Phe Gly Asn Pro Ser Asp Phe Gly Gly Ser Cys Gln Pro Cys 
                965                 970                 975     


Gln Cys His His Asn Ile Asp Thr Thr Asp Pro Glu Ala Cys Asp Lys 
            980                 985                 990         


Glu Thr Gly Arg Cys Leu Lys Cys  Leu Tyr His Thr Glu  Gly Asp His 
        995                 1000                 1005             


Cys Gln  Leu Cys Gln Tyr Gly  Tyr Tyr Gly Asp Ala  Leu Arg Gln 
    1010                 1015                 1020             


Asp Cys  Arg Lys Cys Val Cys  Asn Tyr Leu Gly Thr  Val Lys Glu 
    1025                 1030                 1035             


His Cys  Asn Gly Ser Asp Cys  His Cys Asp Lys Ala  Thr Gly Gln 
    1040                 1045                 1050             


Cys Ser  Cys Leu Pro Asn Val  Ile Gly Gln Asn Cys  Asp Arg Cys 
    1055                 1060                 1065             


Ala Pro  Asn Thr Trp Gln Leu  Ala Ser Gly Thr Gly  Cys Gly Pro 
    1070                 1075                 1080             


Cys Asn  Cys Asn Ala Ala His  Ser Phe Gly Pro Ser  Cys Asn Glu 
    1085                 1090                 1095             


Phe Thr  Gly Gln Cys Gln Cys  Met Pro Gly Phe Gly  Gly Arg Thr 
    1100                 1105                 1110             


Cys Ser  Glu Cys Gln Glu Leu  Phe Trp Gly Asp Pro  Asp Val Glu 
    1115                 1120                 1125             


Cys Arg  Ala Cys Asp Cys Asp  Pro Arg Gly Ile Glu  Thr Pro Gln 
    1130                 1135                 1140             


Cys Asp  Gln Ser Thr Gly Gln  Cys Val Cys Val Glu  Gly Val Glu 
    1145                 1150                 1155             


Gly Pro  Arg Cys Asp Lys Cys  Thr Arg Gly Tyr Ser  Gly Val Phe 
    1160                 1165                 1170             


Pro Asp  Cys Thr Pro Cys His  Gln Cys Phe Ala Leu  Trp Asp Ala 
    1175                 1180                 1185             


Ile Ile  Gly Glu Leu Thr Asn  Arg Thr His Lys Phe  Leu Glu Lys 
    1190                 1195                 1200             


Ala Lys  Ala Leu Lys Ile Ser  Gly Val Ile Gly Pro  Tyr Arg Glu 
    1205                 1210                 1215             


Thr Val  Asp Ser Val Glu Lys  Lys Val Asn Glu Ile  Lys Asp Ile 
    1220                 1225                 1230             


Leu Ala  Gln Ser Pro Ala Ala  Glu Pro Leu Lys Asn  Ile Gly Ile 
    1235                 1240                 1245             


Leu Phe  Glu Glu Ala Glu Lys  Leu Thr Lys Asp Val  Thr Glu Lys 
    1250                 1255                 1260             


Met Ala  Gln Val Glu Val Lys  Leu Thr Asp Thr Ala  Ser Gln Ser 
    1265                 1270                 1275             


Asn Ser  Thr Ala Gly Glu Leu  Gly Ala Leu Gln Ala  Glu Ala Glu 
    1280                 1285                 1290             


Ser Leu  Asp Lys Thr Val Lys  Glu Leu Ala Glu Gln  Leu Glu Phe 
    1295                 1300                 1305             


Ile Lys  Asn Ser Asp Ile Gln  Gly Ala Leu Asp Ser  Ile Thr Lys 
    1310                 1315                 1320             


Tyr Phe  Gln Met Ser Leu Glu  Ala Glu Lys Arg Val  Asn Ala Ser 
    1325                 1330                 1335             


Thr Thr  Asp Pro Asn Ser Thr  Val Glu Gln Ser Ala  Leu Thr Arg 
    1340                 1345                 1350             


Asp Arg  Val Glu Asp Leu Met  Leu Glu Arg Glu Ser  Pro Phe Lys 
    1355                 1360                 1365             


Glu Gln  Gln Glu Glu Gln Ala  Arg Leu Leu Asp Glu  Leu Ala Gly 
    1370                 1375                 1380             


Lys Leu  Gln Ser Leu Asp Leu  Ser Ala Val Ala Gln  Met Thr Cys 
    1385                 1390                 1395             


Gly Thr  Pro Pro Gly Ala Asp  Cys Ser Glu Ser Glu  Cys Gly Gly 
    1400                 1405                 1410             


Pro Asn  Cys Arg Thr Asp Glu  Gly Glu Lys Lys Cys  Gly Gly Pro 
    1415                 1420                 1425             


Gly Cys  Gly Gly Leu Val Thr  Val Ala His Ser Ala  Trp Gln Lys 
    1430                 1435                 1440             


Ala Met  Asp Phe Asp Arg Asp  Val Leu Ser Ala Leu  Ala Glu Val 
    1445                 1450                 1455             


Glu Gln  Leu Ser Lys Met Val  Ser Glu Ala Lys Val  Arg Ala Asp 
    1460                 1465                 1470             


Glu Ala  Lys Gln Asn Ala Gln  Asp Val Leu Leu Lys  Thr Asn Ala 
    1475                 1480                 1485             


Thr Lys  Glu Lys Val Asp Lys  Ser Asn Glu Asp Leu  Arg Asn Leu 
    1490                 1495                 1500             


Ile Lys  Gln Ile Arg Asn Phe  Leu Thr Glu Asp Ser  Ala Asp Leu 
    1505                 1510                 1515             


Asp Ser  Ile Glu Ala Val Ala  Asn Glu Val Leu Lys  Met Glu Met 
    1520                 1525                 1530             


Pro Ser  Thr Pro Gln Gln Leu  Gln Asn Leu Thr Glu  Asp Ile Arg 
    1535                 1540                 1545             


Glu Arg  Val Glu Thr Leu Ser  Gln Val Glu Val Ile  Leu Gln Gln 
    1550                 1555                 1560             


Ser Ala  Ala Asp Ile Ala Arg  Ala Glu Leu Leu Leu  Glu Glu Ala 
    1565                 1570                 1575             


Lys Arg  Ala Ser Lys Ser Ala  Thr Asp Val Lys Val  Thr Ala Asp 
    1580                 1585                 1590             


Met Val  Lys Glu Ala Leu Glu  Glu Ala Glu Lys Ala  Gln Val Ala 
    1595                 1600                 1605             


Ala Glu  Lys Ala Ile Lys Gln  Ala Asp Glu Asp Ile  Gln Gly Thr 
    1610                 1615                 1620             


Gln Asn  Leu Leu Thr Ser Ile  Glu Ser Glu Thr Ala  Ala Ser Glu 
    1625                 1630                 1635             


Glu Thr  Leu Thr Asn Ala Ser  Gln Arg Ile Ser Lys  Leu Glu Arg 
    1640                 1645                 1650             


Asn Val  Glu Glu Leu Lys Arg  Lys Ala Ala Gln Asn  Ser Gly Glu 
    1655                 1660                 1665             


Ala Glu  Tyr Ile Glu Lys Val  Val Tyr Ser Val Lys  Gln Asn Ala 
    1670                 1675                 1680             


Asp Asp  Val Lys Lys Thr Leu  Asp Gly Glu Leu Asp  Glu Lys Tyr 
    1685                 1690                 1695             


Lys Lys  Val Glu Ser Leu Ile  Ala Gln Lys Thr Glu  Glu Ser Ala 
    1700                 1705                 1710             


Asp Ala  Arg Arg Lys Ala Glu  Leu Leu Gln Asn Glu  Ala Lys Thr 
    1715                 1720                 1725             


Leu Leu  Ala Gln Ala Asn Ser  Lys Leu Gln Leu Leu  Glu Asp Leu 
    1730                 1735                 1740             


Glu Arg  Lys Tyr Glu Asp Asn  Gln Lys Tyr Leu Glu  Asp Lys Ala 
    1745                 1750                 1755             


Gln Glu  Leu Val Arg Leu Glu  Gly Glu Val Arg Ser  Leu Leu Lys 
    1760                 1765                 1770             


Asp Ile  Ser Glu Lys Val Ala  Val Tyr Ser Thr Cys  Leu 
    1775                 1780                 1785     


<210>  4
<211>  1607
<212>  PRT
<213>  Mus musculus

<400>  4

Met Thr Gly Gly Gly Arg Ala Ala Leu Ala Leu Gln Pro Arg Gly Arg 
1               5                   10                  15      


Leu Trp Pro Leu Leu Ala Val Leu Ala Ala Val Ala Gly Cys Val Arg 
            20                  25                  30          


Ala Ala Met Asp Glu Cys Ala Asp Glu Gly Gly Arg Pro Gln Arg Cys 
        35                  40                  45              


Met Pro Glu Phe Val Asn Ala Ala Phe Asn Val Thr Val Val Ala Thr 
    50                  55                  60                  


Asn Thr Cys Gly Thr Pro Pro Glu Glu Tyr Cys Val Gln Thr Gly Val 
65                  70                  75                  80  


Thr Gly Val Thr Lys Ser Cys His Leu Cys Asp Ala Gly Gln Gln His 
                85                  90                  95      


Leu Gln His Gly Ala Ala Phe Leu Thr Asp Tyr Asn Asn Gln Ala Asp 
            100                 105                 110         


Thr Thr Trp Trp Gln Ser Gln Thr Met Leu Ala Gly Val Gln Tyr Pro 
        115                 120                 125             


Asn Ser Ile Asn Leu Thr Leu His Leu Gly Lys Ala Phe Asp Ile Thr 
    130                 135                 140                 


Tyr Val Arg Leu Lys Phe His Thr Ser Arg Pro Glu Ser Phe Ala Ile 
145                 150                 155                 160 


Tyr Lys Arg Thr Arg Glu Asp Gly Pro Trp Ile Pro Tyr Gln Tyr Tyr 
                165                 170                 175     


Ser Gly Ser Cys Glu Asn Thr Tyr Ser Lys Ala Asn Arg Gly Phe Ile 
            180                 185                 190         


Arg Thr Gly Gly Asp Glu Gln Gln Ala Leu Cys Thr Asp Glu Phe Ser 
        195                 200                 205             


Asp Ile Ser Pro Leu Thr Gly Gly Asn Val Ala Phe Ser Thr Leu Glu 
    210                 215                 220                 


Gly Arg Pro Ser Ala Tyr Asn Phe Asp Asn Ser Pro Val Leu Gln Glu 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Thr Leu Asn Arg Leu Asn Thr 
                245                 250                 255     


Phe Gly Asp Glu Val Phe Asn Glu Pro Lys Val Leu Lys Ser Tyr Tyr 
            260                 265                 270         


Tyr Ala Ile Ser Asp Phe Ala Val Gly Gly Arg Cys Lys Cys Asn Gly 
        275                 280                 285             


His Ala Ser Glu Cys Val Lys Asn Glu Phe Asp Lys Leu Met Cys Asn 
    290                 295                 300                 


Cys Lys His Asn Thr Tyr Gly Val Asp Cys Glu Lys Cys Leu Pro Phe 
305                 310                 315                 320 


Phe Asn Asp Arg Pro Trp Arg Arg Ala Thr Ala Glu Ser Ala Ser Glu 
                325                 330                 335     


Ser Leu Pro Cys Asp Cys Asn Gly Arg Ser Gln Glu Cys Tyr Phe Asp 
            340                 345                 350         


Pro Glu Leu Tyr Arg Ser Thr Gly His Gly Gly His Cys Thr Asn Cys 
        355                 360                 365             


Arg Asp Asn Thr Asp Gly Ala Lys Cys Glu Arg Cys Arg Glu Asn Phe 
    370                 375                 380                 


Phe Arg Leu Gly Asn Thr Glu Ala Cys Ser Pro Cys His Cys Ser Pro 
385                 390                 395                 400 


Val Gly Ser Leu Ser Thr Gln Cys Asp Ser Tyr Gly Arg Cys Ser Cys 
                405                 410                 415     


Lys Pro Gly Val Met Gly Asp Lys Cys Asp Arg Cys Gln Pro Gly Phe 
            420                 425                 430         


His Ser Leu Thr Glu Ala Gly Cys Arg Pro Cys Ser Cys Asp Leu Arg 
        435                 440                 445             


Gly Ser Thr Asp Glu Cys Asn Val Glu Thr Gly Arg Cys Val Cys Lys 
    450                 455                 460                 


Asp Asn Val Glu Gly Phe Asn Cys Glu Arg Cys Lys Pro Gly Phe Phe 
465                 470                 475                 480 


Asn Leu Glu Ser Ser Asn Pro Lys Gly Cys Thr Pro Cys Phe Cys Phe 
                485                 490                 495     


Gly His Ser Ser Val Cys Thr Asn Ala Val Gly Tyr Ser Val Tyr Asp 
            500                 505                 510         


Ile Ser Ser Thr Phe Gln Ile Asp Glu Asp Gly Trp Arg Val Glu Gln 
        515                 520                 525             


Arg Asp Gly Ser Glu Ala Ser Leu Glu Trp Ser Ser Asp Arg Gln Asp 
    530                 535                 540                 


Ile Ala Val Ile Ser Asp Ser Tyr Phe Pro Arg Tyr Phe Ile Ala Pro 
545                 550                 555                 560 


Val Lys Phe Leu Gly Asn Gln Val Leu Ser Tyr Gly Gln Asn Leu Ser 
                565                 570                 575     


Phe Ser Phe Arg Val Asp Arg Arg Asp Thr Arg Leu Ser Ala Glu Asp 
            580                 585                 590         


Leu Val Leu Glu Gly Ala Gly Leu Arg Val Ser Val Pro Leu Ile Ala 
        595                 600                 605             


Gln Gly Asn Ser Tyr Pro Ser Glu Thr Thr Val Lys Tyr Ile Phe Arg 
    610                 615                 620                 


Leu His Glu Ala Thr Asp Tyr Pro Trp Arg Pro Ala Leu Ser Pro Phe 
625                 630                 635                 640 


Glu Phe Gln Lys Leu Leu Asn Asn Leu Thr Ser Ile Lys Ile Arg Gly 
                645                 650                 655     


Thr Tyr Ser Glu Arg Thr Ala Gly Tyr Leu Asp Asp Val Thr Leu Gln 
            660                 665                 670         


Ser Ala Arg Pro Gly Pro Gly Val Pro Ala Thr Trp Val Glu Ser Cys 
        675                 680                 685             


Thr Cys Pro Val Gly Tyr Gly Gly Gln Phe Cys Glu Thr Cys Leu Pro 
    690                 695                 700                 


Gly Tyr Arg Arg Glu Thr Pro Ser Leu Gly Pro Tyr Ser Pro Cys Val 
705                 710                 715                 720 


Leu Cys Thr Cys Asn Gly His Ser Glu Thr Cys Asp Pro Glu Thr Gly 
                725                 730                 735     


Val Cys Asp Cys Arg Asp Asn Thr Ala Gly Pro His Cys Glu Lys Cys 
            740                 745                 750         


Ser Asp Gly Tyr Tyr Gly Asp Ser Thr Leu Gly Thr Ser Ser Asp Cys 
        755                 760                 765             


Gln Pro Cys Pro Cys Pro Gly Gly Ser Ser Cys Ala Ile Val Pro Lys 
    770                 775                 780                 


Thr Lys Glu Val Val Cys Thr His Cys Pro Thr Gly Thr Ala Gly Lys 
785                 790                 795                 800 


Arg Cys Glu Leu Cys Asp Asp Gly Tyr Phe Gly Asp Pro Leu Gly Ser 
                805                 810                 815     


Asn Gly Pro Val Arg Leu Cys Arg Pro Cys Gln Cys Asn Asp Asn Ile 
            820                 825                 830         


Asp Pro Asn Ala Val Gly Asn Cys Asn Arg Leu Thr Gly Glu Cys Leu 
        835                 840                 845             


Lys Cys Ile Tyr Asn Thr Ala Gly Phe Tyr Cys Asp Arg Cys Lys Glu 
    850                 855                 860                 


Gly Phe Phe Gly Asn Pro Leu Ala Pro Asn Pro Ala Asp Lys Cys Lys 
865                 870                 875                 880 


Ala Cys Ala Cys Asn Pro Tyr Gly Thr Val Gln Gln Gln Ser Ser Cys 
                885                 890                 895     


Asn Pro Val Thr Gly Gln Cys Gln Cys Leu Pro His Val Ser Gly Arg 
            900                 905                 910         


Asp Cys Gly Thr Cys Asp Pro Gly Tyr Tyr Asn Leu Gln Ser Gly Gln 
        915                 920                 925             


Gly Cys Glu Arg Cys Asp Cys His Ala Leu Gly Ser Thr Asn Gly Gln 
    930                 935                 940                 


Cys Asp Ile Arg Thr Gly Gln Cys Glu Cys Gln Pro Gly Ile Thr Gly 
945                 950                 955                 960 


Gln His Cys Glu Arg Cys Glu Thr Asn His Phe Gly Phe Gly Pro Glu 
                965                 970                 975     


Gly Cys Lys Pro Cys Asp Cys His His Glu Gly Ser Leu Ser Leu Gln 
            980                 985                 990         


Cys Lys Asp Asp Gly Arg Cys Glu  Cys Arg Glu Gly Phe  Val Gly Asn 
        995                 1000                 1005             


Arg Cys  Asp Gln Cys Glu Glu  Asn Tyr Phe Tyr Asn  Arg Ser Trp 
    1010                 1015                 1020             


Pro Gly  Cys Gln Glu Cys Pro  Ala Cys Tyr Arg Leu  Val Lys Asp 
    1025                 1030                 1035             


Lys Ala  Ala Glu His Arg Val  Lys Leu Gln Glu Leu  Glu Ser Leu 
    1040                 1045                 1050             


Ile Ala  Asn Leu Gly Thr Gly  Asp Asp Met Val Thr  Asp Gln Ala 
    1055                 1060                 1065             


Phe Glu  Asp Arg Leu Lys Glu  Ala Glu Arg Glu Val  Thr Asp Leu 
    1070                 1075                 1080             


Leu Arg  Glu Ala Gln Glu Val  Lys Asp Val Asp Gln  Asn Leu Met 
    1085                 1090                 1095             


Asp Arg  Leu Gln Arg Val Asn  Ser Ser Leu His Ser  Gln Ile Ser 
    1100                 1105                 1110             


Arg Leu  Gln Asn Ile Arg Asn  Thr Ile Glu Glu Thr  Gly Ile Leu 
    1115                 1120                 1125             


Ala Glu  Arg Ala Arg Ser Arg  Val Glu Ser Thr Glu  Gln Leu Ile 
    1130                 1135                 1140             


Glu Ile  Ala Ser Arg Glu Leu  Glu Lys Ala Lys Met  Ala Ala Ala 
    1145                 1150                 1155             


Asn Val  Ser Ile Thr Gln Pro  Glu Ser Thr Gly Glu  Pro Asn Asn 
    1160                 1165                 1170             


Met Thr  Leu Leu Ala Glu Glu  Ala Arg Arg Leu Ala  Glu Arg His 
    1175                 1180                 1185             


Lys Gln  Glu Ala Asp Asp Ile  Val Arg Val Ala Lys  Thr Ala Asn 
    1190                 1195                 1200             


Glu Thr  Ser Ala Glu Ala Tyr  Asn Leu Leu Leu Arg  Thr Leu Ala 
    1205                 1210                 1215             


Gly Glu  Asn Gln Thr Ala Leu  Glu Ile Glu Glu Leu  Asn Arg Lys 
    1220                 1225                 1230             


Tyr Glu  Gln Ala Lys Asn Ile  Ser Gln Asp Leu Glu  Lys Gln Ala 
    1235                 1240                 1245             


Ala Arg  Val His Glu Glu Ala  Lys Arg Ala Gly Asp  Lys Ala Val 
    1250                 1255                 1260             


Glu Ile  Tyr Ala Ser Val Ala  Gln Leu Thr Pro Val  Asp Ser Glu 
    1265                 1270                 1275             


Ala Leu  Glu Asn Glu Ala Asn  Lys Ile Lys Lys Glu  Ala Ala Asp 
    1280                 1285                 1290             


Leu Asp  Arg Leu Ile Asp Gln  Lys Leu Lys Asp Tyr  Glu Asp Leu 
    1295                 1300                 1305             


Arg Glu  Asp Met Arg Gly Lys  Glu His Glu Val Lys  Asn Leu Leu 
    1310                 1315                 1320             


Glu Lys  Gly Lys Ala Glu Gln  Gln Thr Ala Asp Gln  Leu Leu Ala 
    1325                 1330                 1335             


Arg Ala  Asp Ala Ala Lys Ala  Leu Ala Glu Glu Ala  Ala Lys Lys 
    1340                 1345                 1350             


Gly Arg  Ser Thr Leu Gln Glu  Ala Asn Asp Ile Leu  Asn Asn Leu 
    1355                 1360                 1365             


Lys Asp  Phe Asp Arg Arg Val  Asn Asp Asn Lys Thr  Ala Ala Glu 
    1370                 1375                 1380             


Glu Ala  Leu Arg Arg Ile Pro  Ala Ile Asn Arg Thr  Ile Ala Glu 
    1385                 1390                 1395             


Ala Asn  Glu Lys Thr Arg Glu  Ala Gln Leu Ala Leu  Gly Asn Ala 
    1400                 1405                 1410             


Ala Ala  Asp Ala Thr Glu Ala  Lys Asn Lys Ala His  Glu Ala Glu 
    1415                 1420                 1425             


Arg Ile  Ala Ser Ala Val Gln  Lys Asn Ala Thr Ser  Thr Lys Ala 
    1430                 1435                 1440             


Asp Ala  Glu Arg Thr Phe Gly  Glu Val Thr Asp Leu  Asp Asn Glu 
    1445                 1450                 1455             


Val Asn  Gly Met Leu Arg Gln  Leu Glu Glu Ala Glu  Asn Glu Leu 
    1460                 1465                 1470             


Lys Arg  Lys Gln Asp Asp Ala  Asp Gln Asp Met Met  Met Ala Gly 
    1475                 1480                 1485             


Met Ala  Ser Gln Ala Ala Gln  Glu Ala Glu Leu Asn  Ala Arg Lys 
    1490                 1495                 1500             


Ala Lys  Asn Ser Val Ser Ser  Leu Leu Ser Gln Leu  Asn Asn Leu 
    1505                 1510                 1515             


Leu Asp  Gln Leu Gly Gln Leu  Asp Thr Val Asp Leu  Asn Lys Leu 
    1520                 1525                 1530             


Asn Glu  Ile Glu Gly Ser Leu  Asn Lys Ala Lys Asp  Glu Met Lys 
    1535                 1540                 1545             


Ala Ser  Asp Leu Asp Arg Lys  Val Ser Asp Leu Glu  Ser Glu Ala 
    1550                 1555                 1560             


Arg Lys  Gln Glu Ala Ala Ile  Met Asp Tyr Asn Arg  Asp Ile Ala 
    1565                 1570                 1575             


Glu Ile  Ile Lys Asp Ile His  Asn Leu Glu Asp Ile  Lys Lys Thr 
    1580                 1585                 1590             


Leu Pro  Thr Gly Cys Phe Asn  Thr Pro Ser Ile Glu  Lys Pro 
    1595                 1600                 1605         


