                         SEQUENCE LISTING

<110>  Indiana University Research & Technology Corp
       DiMarchi, Richard
       Yang, Bin
 
<120>  INSULIN-NUCLEAR HORMONE CONJUGATES

<130>  32993-265655

<150>  62/344,674
<151>  2016-06-02

<160>  165   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  3
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210>  4
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  5
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Ile Val Asp Glu Cys Cys Phe Arg Ser Cys Asp Leu Arg Arg Leu 
1               5                   10                  15      


Glu Met Tyr Cys Ala 
            20      


<210>  6
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
1               5                   10                  15      


Glu Thr Tyr Cys Ala 
            20      


<210>  8
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  The Xaa at position 1 represents an amino acid selected from 
       glycine, alanine, valine, leucine, isoleucine, proline, 
       phenylalanine and methionine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  The Xaa at position 2 represents any amino acid other than 
       tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(6)
<223>  The Xaas at positions 3-6 are independently any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  The Xaas at positions 7 and8 are independently selected from 
       arginine, lysine or ornithine

<400>  9

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  The Xaa at position 1 represents an amino acid selected from 
       glycine, alanine, valine, leucine, isoleucine, proline, 
       phenylalanine and methionine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  The Xaa at position 2 represents any amino acid other than 
       tyrosine

<220>
<221>  MISC_FEATURE
<222>  (3)..(6)
<223>  The Xaas at positions 3-6 are independently any amino acid

<400>  10

Xaa Xaa Xaa Xaa Xaa Xaa Arg Arg 
1               5               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  11

Pro Gly Pro Glu 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  12

Phe Val Asn Gln 
1               


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The Xaas at positions 1-5 are independently any amino acid

<400>  13

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  14

Ala Tyr Arg Pro Ser Glu 
1               5       


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  The Xaas at positions 1-4 are independently any amino acid

<400>  15

Xaa Xaa Xaa Xaa 
1               


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  16

Tyr Thr Pro Lys Thr 
1               5   


<210>  17
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Tyr Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Tyr Gly Ser Ser Ser Arg Arg 
1               5               


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine, threonine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is serine, arginine, ornithine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is isoleucine or serine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is aspartic acid or serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is tyrosine, arginine, ornathine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is glutamine, glutamic acid, arginine, 
       ornithine, alanine, lysine or leucine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamic acid, aspartic acid, asparagine, 
       lysine, ornithine or glutamine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is methionine, asparagine, glutamine, glutamic
       acid, aspartic acid or threonine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine, serine, valine, 
       threonine, isoleucine, leucine, glutamine, glutamic acid, 
       asparagine, aspartic acid, histidine, tryptophan, tyrosine, or 
       methionine

<400>  19

Gly Ile Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Xaa Leu Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa Tyr Cys Xaa 
            20      


<210>  20
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is aspartic acid, glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or threonine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamic acid, aspartic acid or asparagine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or phenylalanine

<400>  20

Xaa Leu Cys Gly Xaa Xaa Leu Val Xaa Xaa Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Xaa Xaa Gly Phe Xaa 
            20      


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  analog of IGF-1 C peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  The Xaas at positions 7 and 8 are independently arginine, lysine 
       or ornithine

<400>  21

Gly Tyr Gly Ser Ser Ser Xaa Xaa 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of IGF-1 C peptide

<400>  22

Gly Ala Gly Ser Ser Ser Arg Arg 
1               5               


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  23

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  24
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Arg Val Ser Arg Arg Ser Arg 
1               5               


<210>  25
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or threonine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or phenylalanine

<400>  25

Xaa Leu Cys Gly Xaa Xaa Leu Val Xaa Xaa Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Xaa 
            20      


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid terminal extension for insulin


<220>
<221>  MISC_FEATURE
<222>  (2)..(6)
<223>  the Xaas at positions 2-6 are independently glutamic acid or 
       aspartic acid

<400>  26

Gly Xaa Xaa Xaa Xaa Xaa Lys 
1               5           


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amio acid terminal extension for insulin


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  the Xaas at positions 1-5 are independently glutamic acid or 
       aspartic acid

<400>  27

Xaa Xaa Xaa Xaa Xaa Arg Lys 
1               5           


<210>  28
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of IGF-1 B chain


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  The Xaa at position 28 is alanine lysine, ornithine or arginine

<400>  28

Gly Glu Glu Glu Glu Glu Lys Gly Pro Glu His Leu Cys Gly Ala His 
1               5                   10                  15      


Leu Val Asp Ala Leu Tyr Leu Val Cys Gly Asp Xaa Gly Phe Tyr 
            20                  25                  30      


<210>  29
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine, threonine or phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is serine, arginine, ornithine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is isoleucine or serine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is aspartic acid or serine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is tyrosine, arginine, ornathine, lysine or 
       alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is glutamine, glutamic acid, arginine, 
       ornithine, alanine, lysine or leucine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine, glutamic acid, arginine, 
       aspartic acid, lysine or ornithine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is methionine, asparagine, glutamine, glutamic
       acid, aspartic acid or threonine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position 19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine, serine, valine, 
       threonine, isoleucine, leucine, glutamine, glutamic acid, 
       asparagine, aspartic acid, histidine, tryptophan, tyrosine, or 
       methionine

<400>  29

Gly Ile Val Xaa Xaa Cys Cys Xaa Xaa Xaa Cys Xaa Leu Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa 
            20      


<210>  30
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is  threonine or histidine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position 19 is tyrosine, 4-methoxy-phenylalanine or 
       4-amino phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is asparagine or glycine

<400>  30

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Xaa Cys Xaa 
            20      


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is  histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<400>  31

Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Phe 
            20      


<210>  32
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is asparagine or glycine

<400>  32

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Xaa Asn Tyr Cys Xaa 
            20      


<210>  33
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<400>  33

Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Glu Arg Gly Phe Phe 
            20      


<210>  34
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is phenylalanine and desamino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine and threonine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<400>  34

Xaa Val Asn Gln Xaa Leu Cys Gly Xaa Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr 
            20                  25          


<210>  35
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine or phenylalnine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is arginine, lysine, ornithine or alanine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is arginine, lysine, ornithine or alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is arginine, lysine, ornithine or leucine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is methionine, asparagine or threonine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine or asparagine

<400>  35

Gly Ile Val Asp Glu Cys Cys Xaa Xaa Ser Cys Asp Leu Xaa Xaa Leu 
1               5                   10                  15      


Xaa Xaa Xaa Cys Xaa 
            20      


<210>  36
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is aspartic acid or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or threonine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or phenylalanine

<400>  36

Xaa Leu Cys Gly Xaa Xaa Leu Val Xaa Xaa Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Xaa 
            20      


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is arginine, ornithine, or lysine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is arginine, ornithine, or lysine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is arginine, ornithine, or lysine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine or asparagine

<400>  37

Gly Ile Val Asp Glu Cys Cys His Xaa Ser Cys Asp Leu Xaa Xaa Leu 
1               5                   10                  15      


Xaa Met Xaa Cys Xaa 
            20      


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or phenylalanine

<400>  38

Xaa Leu Cys Gly Ala Xaa Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Xaa 
            20      


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  analog of insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  The Xaa at position 18 is ornithine, lysine or arginine

<400>  39

His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Tyr 
            20      


<210>  40
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  analog of IGF-1 B chain


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  The Xaa at position 21 is ornithine, lysine or arginine

<400>  40

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr 
            20                  


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of IGF-1 B chain


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  The Xaa at position 21 is ornithine, lysine or arginine

<400>  41

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr Phe Asn Pro Lys Thr 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of IGF-1 B chain


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  The Xaa at position 21 is ornithine, lysine or arginine

<400>  42

Gly Pro Glu His Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr Phe Asn Lys Pro Thr 
            20                  25                  


<210>  43
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is arginine, ornithine, or lysine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa at position 14 is arginine, ornithine, or lysine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is arginine, ornithine, or lysine

<400>  43

Gly Ile Val Asp Glu Cys Cys His Xaa Ser Cys Asp Leu Xaa Xaa Leu 
1               5                   10                  15      


Gln Met Tyr Cys Asn 
            20      


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is threonine, histidine or phenylalnine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<400>  44

Gly Ile Val Asp Glu Cys Cys Xaa Arg Ser Cys Asp Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Xaa Cys Asn 
            20      


<210>  45
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine, histidine, asparagine or 
       phenylalanine

<400>  45

Xaa Leu Cys Gly Ser His Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Xaa 
            20      


<210>  46
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine or asparagine

<400>  46

Gly Ile Val Glu Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Xaa Cys Xaa 
            20      


<210>  47
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  The Xaa at position 19 is tyrosine, 4-methoxy-phenylalanine or 
       4-amino phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  The Xaa at position 21 is alanine, glycine or asparagine

<400>  47

Gly Ile Val Asp Glu Cys Cys His Arg Ser Cys Asp Leu Arg Arg Leu 
1               5                   10                  15      


Glu Met Xaa Cys Xaa 
            20      


<210>  48
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Pro Lys Thr 
            20                  25                  


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position1 is glycine, alanine, valine, leucine, 
       isoleucine, proline, phenylalanine and methionine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is any non-aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaas at positions 7 and 8 are independently arginine, lysine, 
       cysteine, homocysteine, acetyl-phenylalanine or ornithine

<400>  49

Xaa Xaa Gly Ser Ser Ser Xaa Xaa 
1               5               


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position1 is glycine, alanine, valine, leucine, 
       isoleucine, proline, phenylalanine and methionine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is any non-aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaas at positions 7 and 8 are independently arginine, lysine or 
       ornithine

<400>  50

Xaa Xaa Gly Ser Ser Ser Xaa Xaa Ala Pro Gln Thr 
1               5                   10          


<210>  51
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  51

Ser Ser Ser Ser Arg Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Lys 
            20                  25                  


<210>  52
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  52

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Arg 
            20                  25                  


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position1 is glycine, alanine, valine, leucine, 
       isoleucine, proline, phenylalanine and methionine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is any non-aromatic amino acid

<400>  53

Xaa Xaa Gly Ser Ser Ser Arg Arg 
1               5               


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of IGF-1 C peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  The Xaa at positions  8 is arginine, lysine or ornithine

<400>  54

Gly Ala Gly Ser Ser Ser Arg Xaa Ala Pro Gln Thr 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is any non-aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is arginine, lysine or ornithine

<400>  55

Gly Xaa Gly Ser Ser Ser Arg Xaa Ala Pro Gln Thr 
1               5                   10          


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is any non-aromatic amino acid

<400>  56

Gly Xaa Gly Ser Ser Ser Arg Arg 
1               5               


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  57

Gly Ala Gly Ser Ser Ser Arg Arg Ala 
1               5                   


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  58

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro 
1               5                   10  


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of IGF-1 C peptide

<400>  59

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln 
1               5                   10      


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  60

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  61

Pro Tyr Gly Ser Ser Ser Arg Arg 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  62

Pro Ala Gly Ser Ser Ser Arg Arg 
1               5               


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  63

Pro Ala Gly Ser Ser Ser Arg Arg Ala 
1               5                   


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  64

Pro Ala Gly Ser Ser Ser Arg Arg Ala Pro 
1               5                   10  


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  65

Pro Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln 
1               5                   10      


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  66

Pro Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  67
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  67

Ser Ser Ser Ser Arg Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  68
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is Lysine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Lysine or Arginine

<400>  68

Ser Ser Ser Ser Xaa Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Xaa 
            20                  25                  


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaas at positions 7 and 8 are independently arginine, lysine or 
       ornithine

<400>  69

Gly Tyr Gly Ser Ser Ser Xaa Xaa Ala Pro Gln Thr 
1               5                   10          


<210>  70
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  70

Tyr Thr Pro Lys 
1               


<210>  71
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  71

Phe Asn Lys Pro 
1               


<210>  72
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 = His, D-histidine, desaminohistidine, 
       hydroxyl-histidine, acetyl-	histidine, homo-histidine or alpha, 
       alpha-dimethyl imidiazole acetic acid (DMIA), 	N-methyl 
       histidine, alpha-methyl histidine, or imidazole acetic acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 = Ser, D-serine, Ala, D-alanine, Val, glycine, 
       n-methyl serine, 	aminoisobutyric acid (AIB) or N-methyl alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Gln, Glu, Orn or  Nle

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 = Tyr, Val or Trp

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 = Ser, Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 = Asp, Glu, cysteic acid, homoglutamic acid 
       and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Gly, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 = Arg, Gln, Lys, Cys, Orn, homocycstein or 
       acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 = Arg, Ala,Lys, Cys, Orn, homocycstein or 
       acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = Gln, Lys, arginine, ornithine or citrulline

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 = Gln, Glu, Asp, Lys, Cys, Orn, homocycstein 
       or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa at position 23 is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Ala, Gln, Glu, Lys, Cys, Orn, homocycstein 
       or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 = Met, Leu, Val or Nle

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 = Asn, Lys or Asp

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr, Gly, Lys, Cys, Orn, homocycstein or 
       acetyl phenyalanine

<400>  72

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  73
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of Insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is  threonine or histidine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is serine, lysine, or alanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, asparagine or glycine

<400>  73

Gly Ile Val Glu Gln Cys Cys Xaa Xaa Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Xaa 
            20      


<210>  74
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is histidine or phenylalnine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is arginine, lysine, ornithine or alanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa at position19 is tyrosine, 4-methoxy phenylalanine  or 
       4-amino-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine or asparagine

<400>  74

Gly Ile Val Asp Glu Cys Cys Xaa Xaa Ser Cys Asp Leu Arg Arg Leu 
1               5                   10                  15      


Glu Met Xaa Cys Xaa 
            20      


<210>  75
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<400>  75

Xaa Leu Cys Gly Ala Xaa Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Asp Xaa Gly Phe Tyr 
            20      


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of IGF-1 C peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  The Xaas at positions 7 and 8 are independently arginine, lysine 
       or ornithine

<400>  76

Gly Ala Gly Ser Ser Ser Xaa Xaa 
1               5               


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of IGF-1 C peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  The Xaas at positions 7 and 8 are independently arginine, lysine 
       or ornithine

<400>  77

Gly Tyr Gly Ser Ser Ser Xaa Xaa Ala Pro Gln Thr 
1               5                   10          


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<400>  78

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  79

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  pegylated

<400>  80

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10      


<210>  81
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 = Asp, Glu, homoglutamic acid, cysteic acid or
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 = Asn, Lys or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 = Thr, Gly or an acidic amino acid

<400>  81

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  82
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 = Asp, Glu, cysteic acid, homoglutamic acid or
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 = Asn, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr or Gly

<400>  82

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  83
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3= Glu, Orn or Nle

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 = Asp, Glu, homoglutamic acid, cysteic acid or
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 = Asn, Lys or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 = Thr or an acidic amino acid

<400>  83

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is Glu or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  84

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  lactam ring formed between side chain of Lys 12 and Glu 16

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is Glu or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  85

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  86
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  lactam ring formed between side chain of Glu 16 and Lys 20

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is Glu or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  86

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  87
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  lactam ring formed between side chain of Lys 20 and Glu 24

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is Glu or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  87

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Thr 
            20                  25                  


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chain of Glu 24 and Lys 28

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Glu or Thr

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  88

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  89
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<400>  89

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  90
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Arg, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<400>  90

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Xaa Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  91
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<400>  91

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  92
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at postion 27 is Met, Leu or Nle

<400>  92

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  93
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<400>  93

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  94
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  94

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  95
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 is Gln, Cys, Orn, homocysteine or acetyl 
       phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<400>  95

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  96
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Glu, Gln, homoglutamic acid or homocysteic 
       acid

<400>  96

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  97
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 = Met, Leu or Nle

<400>  97

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  98
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  98

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  99
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  99

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  lactam ring formed between side chain of Lys 12 and Glu 16

<400>  100

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  101
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  lactam ring formed between side chain of Glu 16 and Lys 20

<400>  101

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  102
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  lactam ring formed between side chain of Lys 20 and Glu 24

<400>  102

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  103
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chain of Glu 24 and Lys 28

<400>  103

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  104
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  lactam ring formed between side chain of Lys 12 and Glu 16

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  lactam ring formed between side chain of Lys 20 and Glu 24

<400>  104

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  105
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  lactam ring formed between side chain of Lys 12 and Glu 16

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chain of Glu 24 and Lys 28

<400>  105

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Asp Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  106
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  lactam ring formed between side chain of Glu 16 and Lys 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chain of Glu 24 and Lys 28

<400>  106

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  107
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa = any amino acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  107

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  108
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = glutamine, lysine, arginine, ornithine or 
       citrulline

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 = Asn, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 = Thr or Gly

<400>  108

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  109
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  lactam ring formed between side chain of Lys 12 and Glu 16

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr or Gly

<400>  109

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  110
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  lactam ring formed between side chain of Glu 16 and Lys 20

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr or Gly

<400>  110

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  111
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  lactam ring formed between side chain of Lys 20 and Glu 24

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 is Asp or Asn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr or Gly

<400>  111

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  112
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  lactam ring formed between side chain of Glu 24 and Lys 28

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr or Gly

<400>  112

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  113
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = glutamine, lysine, arginine, ornithine or 
       citrulline

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 = Asn, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 = Thr or Gly

<400>  113

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  114
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  114

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  115
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue

<400>  115

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  116
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue

<400>  116

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  117

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the amino 4 amino acids of 
       oxyntomodulin carboxy terminus of SEQ ID NO: 27

<400>  118

Lys Arg Asn Arg 
1               


<210>  119
<211>  29
<212>  PRT
<213>  homo sapiens

<400>  119

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  120
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 = His, D-histidine, desaminohistidine, 
       hydroxyl-histidine, acetyl-	histidine, homo-histidine or alpha, 
       alpha-dimethyl imidiazole acetic acid (DMIA), 	N-methyl 
       histidine, alpha-methyl histidine, or imidazole acetic acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 = Ser, D-serine, Ala, D-alanine, Val, glycine, 
       n-methyl serine, 	aminoisobutyric acid (AIB) or N-methyl alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is Gln, Glu, Orn or  Nle

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 = Asp, Glu, cysteic acid, homoglutamic acid 
       and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = Gln, Lys, arginine, ornithine or citrulline

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 = Gln, Glu, Asp, Lys, Cys, Orn, homocycstein 
       or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa at position 23 is Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Ala, Gln, Glu, Lys, Cys, Orn, homocycstein 
       or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 = Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 = Asn, Lys or Asp

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr or Gly, Lys, Cys, Orn, homocycstein or 
       acetyl phenyalanine

<400>  120

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  121
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 = Asp, Glu, homoglutamic acid, cysteic acid or
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 = Asn, Lys or Asp

<400>  121

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Pro Pro Pro Ser 
        35              


<210>  122
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 = Asp, Lys, Cys, Orn, homocycstein or acetyl 
       phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Gln, Lys, Cys, Orn, homocycstein or acetyl 
       phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 = Met, Leu or Nle

<400>  122

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  123
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa at position 15 = Asp, Glu, homoglutamic acid, cysteic acid or
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 = Ser, Glu, Gln, homoglutamic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 = Gln, Lys, Arg, Orn, or citrulline

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 = Asp, Glu, homoglutamic acid, or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa at position 24 = Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 28 = Asn, Lys or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa at position 29 = Thr, Gly or an acidic amino acid

<400>  123

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  124
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  124

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  125
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue

<400>  125

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  126
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue

<400>  126

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  127
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is d-serine, alanine, glycine, n-methyl serine and 
       aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  127

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  128
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  128

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  129
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  129

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  130
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  130

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  131
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  131

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  132
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin conjugate

<400>  132

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Pro Glu His Leu Cys Gly Ala His Leu Val Asp Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Asp Arg Gly Phe Tyr Phe Asn Asp Arg Gly Ala Gly Ser Ser 
    50                  55                  60                  


Ser Arg Arg Gly Ile Val Asp Glu Cys Cys His Arg Ser Cys Asp Leu 
65                  70                  75                  80  


Arg Arg Leu Glu Asn Tyr Cys Asn 
                85              


<210>  133
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin conjugate

<400>  133

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Pro Glu His Leu Cys Gly Ala His Leu Val Asp Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Asp Arg Gly Phe Tyr Phe Asn Asp Arg Gly Ala Gly Ser Ser 
    50                  55                  60                  


Ser Arg Arg Gly Ile Val Asp Glu Cys Cys His Arg Ser Cys Asp Leu 
65                  70                  75                  80  


Arg Arg Leu Glu Asn Ala Cys Asn 
                85              


<210>  134
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin conjugate

<400>  134

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Ala Ile Ala Trp Leu Val Arg Gly Arg Gly Gly 
            20                  25                  30          


Pro Glu His Leu Cys Gly Ala His Leu Val Asp Ala Leu Tyr Leu Val 
        35                  40                  45              


Cys Gly Asp Arg Gly Phe Tyr Phe Asn Asp Arg Gly Ala Gly Ser Ser 
    50                  55                  60                  


Ser Arg Arg Gly Ile Val Asp Glu Cys Cys His Arg Ser Cys Asp Leu 
65                  70                  75                  80  


Arg Arg Leu Glu Asn Tyr Cys Asn 
                85              


<210>  135
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin conjugate

<400>  135

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Glu 
            20                  25                  30          


His Leu Cys Gly Ala His Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
        35                  40                  45              


Asp Arg Gly Phe Tyr Phe Asn Asp Arg Gly Ala Gly Ser Ser Ser Arg 
    50                  55                  60                  


Arg Gly Ile Val Asp Glu Cys Cys His Arg Ser Cys Asp Leu Arg Arg 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  136
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin conjugate

<400>  136

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Glu 
            20                  25                  30          


His Leu Cys Gly Ala His Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
        35                  40                  45              


Asp Arg Gly Phe Tyr Phe Asn Asp Arg Gly Ala Gly Ser Ser Ser Arg 
    50                  55                  60                  


Arg Gly Ile Val Asp Glu Cys Cys His Arg Ser Cys Asp Leu Arg Arg 
65                  70                  75                  80  


Leu Glu Asn Ala Cys Asn 
                85      


<210>  137
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin conjugate

<400>  137

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Glu 
            20                  25                  30          


His Leu Cys Gly Ala His Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
        35                  40                  45              


Asp Arg Gly Phe Tyr Phe Asn Asp Arg Gly Ala Gly Ser Ser Ser Arg 
    50                  55                  60                  


Arg Gly Ile Val Asp Glu Cys Cys His Arg Ser Cys Asp Leu Arg Arg 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  138
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin conjugate

<400>  138

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Glu 
            20                  25                  30          


His Leu Cys Gly Ala His Leu Val Asp Ala Leu Tyr Leu Val Cys Gly 
        35                  40                  45              


Asp Arg Gly Phe Tyr Phe Asn Asp Arg Gly Ala Gly Ser Ser Ser Arg 
    50                  55                  60                  


Arg Gly Ile Val Asp Glu Cys Cys His Arg Ser Cys Asp Leu Arg Arg 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  139
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate of GLP-1 and insulin

<400>  139

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Phe 
            20                  25                  30          


Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu 
        35                  40                  45              


Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ala Gly 
    50                  55                  60                  


Ser Ser Ser Arg Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys 
65                  70                  75                  80  


Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
                85                  90  


<210>  140
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Conjugate of glucagon and insulin

<400>  140

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Phe Val Asn 
            20                  25                  30          


Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys 
        35                  40                  45              


Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ala Gly Ser Ser 
    50                  55                  60                  


Ser Arg Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu 
65                  70                  75                  80  


Tyr Gln Leu Glu Asn Tyr Cys Asn 
                85              


<210>  141
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  141

Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly 
1               5                   10                  15      


Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu 
            20                  25                  30          


Gln Lys Arg 
        35  


<210>  142
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin B chain


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is alanine, glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is histidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is aspartic acid, glutamine or glutamic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or threonine

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is glutamic acid, aspartic acid or asparagine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is alanine, ornithine, lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is tyrosine or phenylalanine

<400>  142

Xaa Leu Cys Gly Xaa Xaa Leu Val Xaa Xaa Leu Tyr Leu Val Cys Gly 
1               5                   10                  15      


Xaa Xaa Gly Phe Xaa Tyr Thr 
            20              


<210>  143
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain insulin analog

<400>  143

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Gly Ala 
            20                  25                  30          


Gly Ser Ser Ser Arg Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile 
        35                  40                  45              


Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  


<210>  144
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain insulin analog


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is histidine or threonine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is ihistidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine ornithine or arginine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 21 is lysine or aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 21 is proline, ornithine or arginine

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa at position 21 is phenylalanine or histidine

<400>  144

Gly Pro Glu Xaa Leu Cys Gly Ala Xaa Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr Phe Asn Xaa Xaa Gly Ala Gly Ser 
            20                  25                  30          


Ser Ser Arg Arg Gly Ile Val Asp Glu Cys Cys Xaa Arg Ser Cys Asp 
        35                  40                  45              


Leu Arg Arg Leu Glu Asn Tyr Cys Asn 
    50                  55          


<210>  145
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain insulin analog

<400>  145

Gly Pro Glu His Leu Cys Gly Ala His Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Asp Arg Gly Ala Gly Ser 
            20                  25                  30          


Ser Ser Arg Arg Gly Ile Val Asp Glu Cys Cys His Arg Ser Cys Asp 
        35                  40                  45              


Leu Arg Arg Leu Glu Asn Tyr Cys Asn 
    50                  55          


<210>  146
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  146

Gly Gly Gly Lys 
1               


<210>  147
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  147

Phe Val Lys Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe 
            20                  25  


<210>  148
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  148

Phe Val Asn Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe 
            20                  25  


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of insulin


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is proline, aspartic acid or glutamic acid

<400>  149

Tyr Thr Xaa Lys Thr 
1               5   


<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of insulin

<400>  150

Tyr Thr Lys Pro Thr 
1               5   


<210>  151
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of insulin

<400>  151

Tyr Thr Lys Pro Thr 
1               5   


<210>  152
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of insulin


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is proline, aspartic acid or glutamic acid

<400>  152

Tyr Thr Xaa Lys 
1               


<210>  153
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is threonine or histidine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is asparagine, glycine or alanine

<400>  153

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Xaa 
            20      


<210>  154
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  154

Phe Val Asn Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Glu Lys Thr 
            20                  25                  30  


<210>  155
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  155

Phe Val Asn Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  156
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  156

Phe Val Asn Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  157
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  157

Phe Val Asn Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  158
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  158

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Lys 
            20                  25                  


<210>  159
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  159

Ser Ser Ser Ser Arg Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln Lys 
            20                  25                  


<210>  160
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Analog of the insulin A chain


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine, glycine or asparagine

<400>  160

Gly Ile Val Glu Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Xaa 
            20      


<210>  161
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  161

Phe Val Asn Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  162
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  162

Phe Val Asn Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Glu Lys Thr 
            20                  25                  30  


<210>  163
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain insulin analog


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is ihistidine, aspartic acid, glutamic acid, 
       homocysteic acid or cysteic acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa at position 21 is alanine ornithine or arginine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is lysine or aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa at position 21 is proline, ornithine or arginine

<400>  163

Gly Pro Glu His Leu Cys Gly Ala Xaa Leu Val Asp Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Asp Xaa Gly Phe Tyr Phe Asn Xaa Xaa 
            20                  25              


<210>  164
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  164

Phe Val Asn Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  165
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is histidine or threonine

<400>  165

Phe Val Asn Gln Xaa Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


