                         SEQUENCE LISTING

<110>  Indiana University Research & Technology Corp
       DiMarchi, Richard
       Finan, Brian
       Yang, Bin
       Zhu, Zhimeng
 
<120>  GLUCAGON-T3 CONJUGATES

<130>  32993-265652

<150>  62/344,664
<151>  2016-06-02

<160>  935   

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Xaa Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  4

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  6

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  7

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<400>  8

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  9

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  10

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  11

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at position 12 and 16

<400>  12

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  13

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (22)..(24)
<223>  Lactam ring between side chains at positions 22 and 24

<400>  14

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring formed between side chains at positions 24 and 28

<400>  15

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<400>  16

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<400>  17

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Asp Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  18

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Variable amino acid

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  20

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, Ala, Gly, N-methyl Ser or AIB

<400>  21

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  23

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  24

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  25

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids Exendin-4


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is Lys or Cys

<400>  26

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
1               5                   10      


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 8 
       amino acids of oxyntomodulin


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is Lys or Cys

<400>  27

Lys Arg Asn Arg Asn Asn Ile Ala Xaa 
1               5                   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is Lys or Cys

<400>  28

Lys Arg Asn Arg Xaa 
1               5   


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exendin-4


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  29

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  30
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  30

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  31
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  31

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  32

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  33

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  35

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  36
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  36

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cys

<400>  37

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Carboxymethyl group bound through thiol group of Cys

<400>  38

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  39

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  40

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  41

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  42

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  43
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  43

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Thr 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Glu or Thr

<400>  44

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Lys or Glu

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Gln, Glu, Lys, homoglutamic acid, cysteic acid or 
       homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Glu or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Lys or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  45

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<400>  46

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  47
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  47

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  48
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  48

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  49

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  50
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  50

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  51
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn, or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Glu, homoglutamic acid, or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  51

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  52
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  52

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  53
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or an acidic amino acid

<400>  53

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  54
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg or Gln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Arg or Ala

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp or Glu

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Ala

<400>  54

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Xaa Xaa Ala Lys Xaa Phe Xaa Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  55
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His or
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Tyr or Trp

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Lys, Citrulline, Orn or Arg

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg, Gln, Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Arg, Ala, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocystein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Arg, Citrulline, Orn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl phenyalanine

<400>  55

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  56
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Cys, Orn, homocycsteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl phenyalanine

<400>  56

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl- His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side changes at position 12 and 16

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Cys, Orn, homocycsteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  57

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  58
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  58

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB, or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at position 20 and 24

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl pheylalanine

<400>  59

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Glu Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  60
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn, or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at position 24 and 28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  60

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Glu Trp Leu Xaa Lys Xaa 
            20                  25                  


<210>  61
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, Aib, N-methyl, Ala or 
       D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG or not present

<400>  61

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Xaa Ala Lys Asp Phe Val Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  62
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, AIB0, N-methyl Ala, or 
       D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG or not present

<400>  62

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Xaa Ala Lys Glu Phe Ile Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  63
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Lys, Cys, Orn, homocysteine or acetyl phealanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Lys, Cys, Orn, homocysteine or acetyl phealanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  63

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  64
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<400>  64

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Pro Pro Pro Ser 
        35              


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exdendin-4


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Cys-PEG

<400>  65

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10      


<210>  66
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  66

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  67

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  68
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  68

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  69
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  69

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  70

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  71
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  71

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  72
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  72

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  73
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  73

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  74
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  74

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  75
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  75

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  76
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  76

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  77
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  77

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  78
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  78

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  79
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  79

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  80
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  80

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  81
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  81

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  82
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  82

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  83
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  83

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  84

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  85

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  86
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  86

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  87
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  87

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  88

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  89
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  89

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  90
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  90

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  91
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  91

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  92
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  92

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  93
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  93

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  94
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  94

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  95
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  95

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  96
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  96

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  97
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  97

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  98
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  98

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  99
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  99

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  100

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  101
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  101

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  102
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C-terminal amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  102

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  103
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C-terminal amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  103

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  104
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  104

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  105
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  105

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  106
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  106

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  107
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  107

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  108
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  108

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  109
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  109

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  110
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  110

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  111
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  111

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  112
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  112

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  113
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  113

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  114
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  114

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  115
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  115

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  116
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  116

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  117
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  117

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  118
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  118

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  119
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  119

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  120
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  120

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  121
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  121

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  122
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  122

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  123
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  123

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  124
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  124

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  125
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  125

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  126
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  126

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  127
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  127

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  128
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  128

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  129
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  129

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  130
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  130

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  131
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  131

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  132
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  132

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  133
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  133

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  134
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  134

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  135
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  135

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  136
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  136

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  137
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  137

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  138
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  138

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  139
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  139

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  140
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  140

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  141
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  141

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  142
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  142

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  143
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  143

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  144
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  144

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  145
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  145

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  146
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  146

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  147
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  147

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  148
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  148

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  149
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  149

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  150
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  150

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  151
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  151

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  152
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  152

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  153
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  153

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  154
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  154

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  155
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  155

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  156
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  156

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  157
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  157

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  158
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  158

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  159
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  159

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  160
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  160

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  161
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  161

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  162
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  162

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  163
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  163

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  164
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  164

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  165
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  165

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  166
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  166

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  167
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  167

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  168
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  168

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  169
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  169

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  170
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  170

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  171
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  171

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  172
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  172

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  173
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  173

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  174
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  174

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  175
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  175

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  176
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  176

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  177
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  177

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  178
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  178

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  179
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  179

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  180
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  180

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  181
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  181

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  182
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  182

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  183
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  183

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  184
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  184

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  185
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  185

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  186
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  186

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  187
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  187

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  188
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  188

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  189
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  189

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  190
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  190

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  191
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  191

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  192
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  192

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  193
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  193

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  194
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  194

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  195
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  195

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  196
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  196

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  197
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  197

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  198
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  198

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  199
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  199

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  200
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  200

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  201
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  201

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  202
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  202

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  203
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  203

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  204
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  204

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  205
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  205

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  206
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  206

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  207
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  207

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  208
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  208

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  209
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  209

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  210
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  210

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  211
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  211

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  212
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  212

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  213
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  213

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  214
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  214

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  215
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  215

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  216
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  216

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  217
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  217

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  218
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  218

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  219
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  219

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  220
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  220

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  221
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  221

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  222
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  222

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  223
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  223

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  224
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  224

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  225
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  225

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  226
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  226

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  227
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  227

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  228
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  228

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  229
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  229

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  230
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  230

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  231
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  231

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  232
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  232

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  233
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  233

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  234
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  234

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  235
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  XAa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  235

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  236
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  236

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  237
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  237

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  238
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  238

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  239
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  239

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  240
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  240

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  241
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  241

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  242
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  242

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  243
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  243

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  244
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  244

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  245
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  245

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  246
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  246

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  247
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  247

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  248
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  248

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  249
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  249

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  250
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  250

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  251
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  251

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  252
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  252

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  253
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  253

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  254
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  254

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  255
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  255

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  256
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  256

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  257
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  257

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  258
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  258

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  259
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  259

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  260
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chrains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  260

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  261
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  261

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  262
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  262

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  263
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  263

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  264
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  264

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  265
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  265

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  266
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring betwee side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  266

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  267
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  267

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  268
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  268

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  269
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring betwee side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  269

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  270
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring betwee side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  270

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  271
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  271

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  272
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal midation

<400>  272

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  273
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  273

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  274
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  274

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  275
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  275

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  276
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  276

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  277
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  277

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  278
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  278

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  279
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  279

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  280
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  280

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  281
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  281

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  282
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  282

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  283
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  283

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  284
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  284

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  285
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  285

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  286
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  286

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  287
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chain at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  287

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  288
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  288

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  289
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  289

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  290
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  290

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  291
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  291

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  292
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  292

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  293
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  293

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  294
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  294

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  295
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  295

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  296
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  296

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  297
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  297

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  298
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  298

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  299
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  299

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  300
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  300

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  301
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  301

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  302
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  302

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  303
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  303

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  304
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  304

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  305
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  305

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  306
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  306

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  307
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  307

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  308
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  308

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  309
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  309

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  310
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  310

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  311
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chain at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  311

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  312
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  312

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  313
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  313

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  314
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  314

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  315
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between seide chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  315

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  316
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  316

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  317
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  317

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  318
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  318

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  319
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  319

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  320
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  320

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  321
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at position 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  321

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  322
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  322

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  323
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  323

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  324
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at position 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  324

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  325
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  325

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  326
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  326

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  327
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  327

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  328
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  328

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  329
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  329

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  330
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  330

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  331
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  331

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  332
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  332

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  333
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  333

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  334
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  334

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  335
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chainst at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  335

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  336
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  336

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  337
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  337

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  338
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam right between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  338

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  339
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  339

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  340
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  340

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  341
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  341

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  342
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  342

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  343
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  343

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  344
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  344

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  345
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  345

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  346
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  346

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  347
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  347

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  348
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  348

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  349
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  349

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  350
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  350

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  351
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  351

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  352
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  352

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  353
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  353

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  354
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  354

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  355
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  355

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  356
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  356

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  357
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  357

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  358
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  358

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  359
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  359

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  360
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  360

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  361
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  361

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  362
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  362

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  363
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  363

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  364
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  364

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  365
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  365

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  366
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  366

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  367
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  367

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  368
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  368

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  369
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  369

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  370
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  370

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  371
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  371

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  372
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  372

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  373
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  373

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  374
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  374

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  375
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  375

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  376
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  376

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  377
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  377

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  378
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  378

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  379
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  379

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  380
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  380

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  381
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  381

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  382
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  382

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  383
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  383

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  384
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  384

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  385
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  385

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  386
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  386

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  387
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  387

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  388
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  388

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  389
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  389

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  390
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  390

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  391
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  391

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  392
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  392

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  393
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  393

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  394
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  394

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  395
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  395

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  396
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  396

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  397
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  397

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  398
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  398

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  399
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  399

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  400
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  400

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  401
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  401

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  402
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  402

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  403
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  403

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  404
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  404

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  405
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  405

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  406
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  406

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  407
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  407

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  408
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  c-term amidation

<400>  408

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  409
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  409

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  410
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  410

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  411
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  411

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  412
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  412

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  413
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  413

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  414
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  414

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  415
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  415

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  416
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  416

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  417
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  417

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  418
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  418

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  419
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  419

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  420
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  420

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  421
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  421

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  422
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  422

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  423
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  423

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  424
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  424

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  425
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  425

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  426
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  426

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  427
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  427

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  428
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  428

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  429
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  429

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  430
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  430

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  431
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  431

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  432
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  432

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  433
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  433

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  434
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  434

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  435
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  435

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  436
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  436

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  437
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  Lactam ring between side chains at positions 16 and 20

<400>  437

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  438
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  438

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  439
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  439

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  440
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  440

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  441
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  441

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  442
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  442

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  443
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  443

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  444
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  444

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  445
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  445

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  446
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  446

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  447
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  447

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  448
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  448

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  449
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  449

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  450
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  450

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  451
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  451

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  452
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  C-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  452

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  453
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  453

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  454
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  454

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  455
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  455

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  456
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  456

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  457
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  457

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  458
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  458

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  459
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  459

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  460
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  460

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  461
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  461

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  462
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  462

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  463
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  463

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  464
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  464

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  465
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  465

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  466
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at postions 12 and 16

<400>  466

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  467
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  467

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  468
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  468

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  469
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  469

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  470
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  470

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  471
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  471

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  472
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  472

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  473
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  473

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  474
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  474

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  475
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  475

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  476
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  476

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  477
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  477

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  478
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  478

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  479
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  479

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  480
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  480

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  481
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  481

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  482
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  482

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  483
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  483

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  484
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  484

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  485
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  485

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  486
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  486

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  487
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  487

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  488
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  488

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  489
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  489

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  490
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  490

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  491
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  491

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  492
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  492

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  493
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  493

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  494
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  494

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  495
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  495

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  496
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  496

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  497
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  497

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  498
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  498

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr Ala 
            20                  25                  30  


<210>  499
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  499

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  500
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  500

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  501
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  501

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  502
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  502

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  503
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  503

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  504
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  504

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  505
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  505

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  506
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethly Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  506

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  507
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  507

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  508
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  508

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  509
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  509

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  510
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  510

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  511
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  511

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  512
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  512

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  513
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  513

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  514
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  514

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  515
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  515

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  516
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Cys-PEG

<400>  516

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10          


<210>  517
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  517

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  518
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  518

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  519
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethly Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  519

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  520
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  520

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  521
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  521

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  522
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  522

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  523
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  523

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  524
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  524

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  525
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  525

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  526
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  526

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  527
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  527

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly 
            20                  25                  30  


<210>  528
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  528

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  529
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  529

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  530
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  530

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  531
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  531

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  532
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Cys-PEG

<400>  532

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys Cys 
        35                  40      


<210>  533
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  c-term amidation

<400>  533

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  534
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C8 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C8 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  534

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  535
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C14 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C14 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  535

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  536
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C16 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  536

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  537
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  537

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  538
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  538

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  539
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  539

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  540
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C18

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C18 fatty acid

<400>  540

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  541
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C16 Cys24-40K

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  541

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  542
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acid

<400>  542

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  543
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<400>  543

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  544
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acid

<400>  544

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  545
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  545

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  546
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C16 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  546

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  547
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  547

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  548
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  548

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  549
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16 amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Glu residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  549

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  550
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 truncated by one amino acid

<400>  550

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn 
            20                  25              


<210>  551
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 truncated by two amino acids

<400>  551

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met 
            20                  25          


<210>  552
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  aa 1-28, E16 K20 C-terminal amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  552

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn 
            20                  25              


<210>  553
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  aa 1-27 E16 K20 C-terminal amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  553

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Lys Met 
            20                  25          


<210>  554
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Norleucine

<400>  554

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  555
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridging side chains at positions 16 and 20

<400>  555

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  556
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 with AIB at 16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  556

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  557
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  557

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  558
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  558

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  559
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutric Acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutric Acid

<400>  559

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  560
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  560

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  561
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aminoisobutyric acid

<400>  561

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  562
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  562

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  563
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  563

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  564
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  564

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  565
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  565

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  566
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  566

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  567
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via 6-aminohexanoic acid 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  567

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  568
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Leu-Leu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  568

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  569
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Pro-Pro spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  569

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  570
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  570

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  571
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  571

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  572
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  572

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  573
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  573

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  574
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  574

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  575
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  575

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  576
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  576

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  577
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  577

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  578
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  578

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  579
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  AA-C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<400>  579

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  580
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2, AIB2, Lys10, Cys24-PEG

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  580

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  581
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C14 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<400>  581

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  582
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C14)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<400>  582

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  583
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C16 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<400>  583

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  584
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C16)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  584

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  585
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Chimera 2-AIB2-K10-acylated

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  585

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  586
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Chimera 2-AIB2-K30-acylated

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C18 fatty acyl group

<400>  586

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  587
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<400>  587

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  588
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  588

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  589
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<400>  589

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  590
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  590

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  591
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  591

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  592
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  592

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  593
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  593

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  594
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetamidomethyl-cysteine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  594

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  595
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  595

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  596
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is carbamoyldiaminopropanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  596

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  597
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  597

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  598
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methionine sulfoxide

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  598

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  599
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Acetylornithine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  599

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  600
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  600

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  601
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  601

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  602
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  602

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  603
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  603

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Glu 
            20                  25                  


<210>  604
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  604

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  605
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  605

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ser Asp Phe Val Ser Trp Leu Leu Asp Glu 
            20                  25                  


<210>  606
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  606

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Thr Asp Phe Val Thr Trp Leu Leu Asp Glu 
            20                  25                  


<210>  607
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  607

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  608
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  608

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  609
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  609

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  610
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  610

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  611
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  611

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  612
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  612

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  613
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<400>  613

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  614
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<400>  614

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  615
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C18 fatty acyl group

<400>  615

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  616
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  616

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  617
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  617

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  618
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  618

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  619
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via di peptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  619

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  620
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covelently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  620

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  621
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  621

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  622
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  622

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  623
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  beta-Ala-beta-Ala - C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<400>  623

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  624
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera-2 Aib2C24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  624

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  625
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera-2 Aib2E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of the amino acids at positions 
       16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  625

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  626
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2E16K20lactamC24amideMal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  626

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  627

<400>  627
000

<210>  628
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  628

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  629
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<400>  629

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  630
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24thioether40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at position 16 and
       20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  630

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  631
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera2 Aib2E3C24-Thioether40K PEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  631

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  632
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  632

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  633
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16C24K10(rErE-C16) C24PEG40K amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  633

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  634
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(AA-C14)C24PEG40K TE amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  634

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  635
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(AA-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  635

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  636
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(rErE-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  636

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  637
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  637

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  638
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  638
caaggtccag ggaggttgtg                                                   20


<210>  639
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  639
ccaaaggtaa gctgtccata agga                                              24


<210>  640
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  640
ctctcccaag agtcacatgt cc                                                22


<210>  641
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  641
caataactcg gtcccctaca ac                                                22


<210>  642
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  642

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  643
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  643

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  644
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  644

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  645
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  645

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  646
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  646

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  647
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  647

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  648
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  648

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  649
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  649

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  650
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  650

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  651
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  651

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  652
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  652

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  653
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  653

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  654
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  654

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  655
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  655

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  656
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  656

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  657
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  657

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  658
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  658

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  659
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  659

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  660
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  660

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  661
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  661

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  662
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C14 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<400>  662

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  663
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C14)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<400>  663

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  664
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C16 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<400>  664

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  665
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C16)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  665

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  666
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<400>  666

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  667
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<400>  667

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  668
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C18 fatty acyl group

<400>  668

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  669
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  669

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  670
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16C24K10(rErE-C16) C24PEG40K amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  670

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  671
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(rErE-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  671

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  672
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  672

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  673
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  673

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  674
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  674

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  675
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  675

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  676
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  676

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  677
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  677

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  678
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  678

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  679
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  679

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  680
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  680

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  681
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  681

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  682
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  682

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  683
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  683

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  684
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  684

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  685
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  685

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Xaa Gly Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  686
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  686

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  687
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  687

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  688
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  688

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  689
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  689

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  690
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<400>  690

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  691
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  691

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  692
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  692

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Glu Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  693
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  693

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  694
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  694

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  695
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  695

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Asp Thr 
            20                  25                  


<210>  696
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  696

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  697
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  697

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  698
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  698

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  699
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  699

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  700
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  700

His Ala Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  701
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  701

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  702
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  702

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  703
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  703

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  704
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<400>  704

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  705
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  705

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Glu 
            20                  25                  30      


<210>  706
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<400>  706

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Gly 
            20                  25                  30      


<210>  707
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  707

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  708
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  708

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  709
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  709

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu 
            20                  25                  30  


<210>  710
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<400>  710

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  711
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  711

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  712
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  des-amino-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  712

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  713
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ac-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  713

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  714
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  714

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  715
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  715

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  716
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  716

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  717
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  717

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  718
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  718

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  719
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  719

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  720
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  720

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  721
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  721

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  722
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  722

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  723
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  723

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  724
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  724

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  725
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  725

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  726
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  726

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  727
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  727

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  728
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  728

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  729
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  729

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  730
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (15)..(20)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  730

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  731
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  731

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  732
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  732

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  733
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  733

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  734
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  734

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  735
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  735

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  736
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  736

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  737
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  737

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  738
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  738

His Ala Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  739
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  739

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  740
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  740

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  741
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  741

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  742
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<400>  742

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  743
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  743

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Glu 
            20                  25                  30      


<210>  744
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<400>  744

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Gly 
            20                  25                  30      


<210>  745
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  745

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  746
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  746

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  747
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  747

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu 
            20                  25                  30  


<210>  748
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<400>  748

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  749
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  749

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  750
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  des-amino-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  750

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  751
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ac-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  751

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  752
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  752

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  753
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  753

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  754
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  754

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  755
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  755

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  756
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  756

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  757
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  757

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  758
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  758

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  759
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  759

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  760
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MISC_FEATURE
<222>  (15)..(20)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  760

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  761

<400>  761
000

<210>  762

<400>  762
000

<210>  763

<400>  763
000

<210>  764

<400>  764
000

<210>  765

<400>  765
000

<210>  766

<400>  766
000

<210>  767

<400>  767
000

<210>  768

<400>  768
000

<210>  769

<400>  769
000

<210>  770

<400>  770
000

<210>  771

<400>  771
000

<210>  772

<400>  772
000

<210>  773

<400>  773
000

<210>  774

<400>  774
000

<210>  775

<400>  775
000

<210>  776

<400>  776
000

<210>  777

<400>  777
000

<210>  778

<400>  778
000

<210>  779

<400>  779
000

<210>  780

<400>  780
000

<210>  781

<400>  781
000

<210>  782

<400>  782
000

<210>  783

<400>  783
000

<210>  784

<400>  784
000

<210>  785

<400>  785
000

<210>  786

<400>  786
000

<210>  787

<400>  787
000

<210>  788

<400>  788
000

<210>  789

<400>  789
000

<210>  790

<400>  790
000

<210>  791

<400>  791
000

<210>  792

<400>  792
000

<210>  793

<400>  793
000

<210>  794

<400>  794
000

<210>  795

<400>  795
000

<210>  796

<400>  796
000

<210>  797

<400>  797
000

<210>  798

<400>  798
000

<210>  799

<400>  799
000

<210>  800

<400>  800
000

<210>  801
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  801

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  802
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  802

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  803
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa is Arg, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  803

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  804
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  804

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  805
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  805

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  806
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  806

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  807
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Lys, Arg, His, Asp, Glu, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Lys, Arg, His, Asp, Glu, cysteic acid or homocysteic 
       acid

<400>  807

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  808
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asp or Glu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Asp or Glu

<400>  808

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  809
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Asp or Glu

<400>  809

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Xaa 
            20                  25                  


<210>  810
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  810

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  811
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  811

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  812
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Lys, Arg or His

<400>  812

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Xaa 
            20                  25                  


<210>  813
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  813

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  814
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  814

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  815
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  815

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  816
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  816

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  817
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  817

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  818
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  818

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Lys Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  819
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  819

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Lys Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  820
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing carboxy terminal 10 amino acids of 
       Exendin-4

<400>  820

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  821
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  821

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  822
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the amino 4 amino acids of 
       oxyntomodulin carboxy terminus of SEQ ID NO: 21

<400>  822

Lys Arg Asn Arg 
1               


<210>  823
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  823

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  824
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  824

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  825
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  825

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  826
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  826

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  827
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  827

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  828
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  828

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  829
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through Cys thiol group

<400>  829

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  830
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Carboxymethyl group bound through Cys thiol group

<400>  830

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  831
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  831

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  832
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analog


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Xaa is Asp, Glu, Lys, Arg or His

<400>  832

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Xaa 
            20                  25                  30  


<210>  833
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Lys, Arg, His, Asp or Glu

<400>  833

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  834
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr or an acidic amino acid

<400>  834

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  835
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  835

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  836
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  836

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  837
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  837

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  838
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  838

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr 
            20                  25                  


<210>  839
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Ser, D-Ser, Ala, D-Ala, Gly, N-methyl-Ser, Aib, Val, or 
       alpha-amino-N-butyric acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met comprises Z

<400>  839

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met 
            20                  25          


<210>  840
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylation

<400>  840

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  841
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Glutamine to alanine mutation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Pegylation

<400>  841

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  842
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle or Leu

<400>  842

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  843
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Glutamine to alanine mutation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Nle or Leu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Pegylation

<400>  843

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Ala Trp Leu Xaa Asn Cys 
            20                  25                  


<210>  844
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with  Ala 20, Ala 24, Nle 27, and Asp 28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  844

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  845
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle27 , Asp 28, and Glu 29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  845

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  846
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle 27, Asp 28, and Glu 30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  846

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asp Thr Glu 
            20                  25                  30  


<210>  847
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle 27, Glu 28, and Glu 29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  847

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Glu Glu 
            20                  25                  


<210>  848
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle 27, Glu 28, and Glu 30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  848

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Glu Thr Glu 
            20                  25                  30  


<210>  849
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle 27, Glu 29, and Glu 30

<400>  849

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asn Glu Glu 
            20                  25                  30  


<210>  850
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, and Asp 28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  850

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  851
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, Asp 28, and Glu
       29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  851

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  852
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, Asp 28, and Glu
       30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  852

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  853
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO :1 with Ala 20, Glu 21, Ala 24, Nle 27, Glu 28, and Glu
       29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  853

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Glu Glu 
            20                  25                  


<210>  854
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, Glu 28, and Glu
       30

<400>  854

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  855
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, Glu 29, and Glu
       30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  855

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asn Glu Glu 
            20                  25                  30  


<210>  856
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Thr 16, Ala 20, Glu 21, Ala 24, Nle 27, Asp 28,
       and Glu29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  856

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  857
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  857

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  858
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  858

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  859
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Glutamine analog

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  859

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  860
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Glutamine analog

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic acid

<400>  860

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  861
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  861

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  862
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetamidomethyl-cysteine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  862

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  863
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  863

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  864
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Carbamoyldiaminopropanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  864

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  865
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  865

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  866
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methionine sulfoxide

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  866

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  867
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetylornithine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  867

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  868
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic acid

<400>  868

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  869
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic acid

<400>  869

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  870
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  870

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  871
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  871

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Glu 
            20                  25                  


<210>  872
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  AMIDATION

<400>  872

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  873
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryric acid

<400>  873

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ser Asp Phe Val Ser Trp Leu Leu Asp Glu 
            20                  25                  


<210>  874
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic acid

<400>  874

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Thr Asp Phe Val Thr Trp Leu Leu Asp Glu 
            20                  25                  


<210>  875
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  875

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Glu 
            20                  25                  


<210>  876
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  876

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Glu 
            20                  25                  


<210>  877
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  877

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  878
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  878

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  879
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  879

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  880
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  880

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  881
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  881

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  882
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  882

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  883
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  883

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  884
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  884

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  885
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser or alpha, alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln or alpha, alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp or alpha, alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or alpha, alpha-disubstituted amino acid

<400>  885

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  886
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  886

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  887
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa is Aib

<400>  887

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Xaa Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  888
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<400>  888

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  889
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Aib

<400>  889

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  890
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Aib

<400>  890

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  891
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<400>  891

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  892
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Aib

<400>  892

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  893
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Aib

<400>  893

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  894
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Aib

<400>  894

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  895
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  895

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  896
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  896

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  897
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  897

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  898
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  898

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  899
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  899

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  900
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  900

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  901
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via 6-aminohexanoic acid 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  901

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  902
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Leu-Leu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  902

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  903
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Pro-Pro spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  903

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  904
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  904

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  905
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  905

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  906
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  906

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  907
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  907

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  908
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  908

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  909
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  909

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  910
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  910

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  911
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  911

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  912
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  912

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  913
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  913

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  914
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  914

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  915
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covelently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  915

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  916
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  916

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  917
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  917

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  918
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  918

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  919
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  919

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  920
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is His, D-His, N-methyl-His, alpha-methyl-His, 
       imidazole acetic acid, des-amino-His, hydroxyl-His, acetyl-His, 
       homo-His, or alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is Ser, D-Ser, Ala, D-Ala, Gly, N-methyl-Ser, 
       AIB, Val, or alpha-amino-N-butyric acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is a glutamine analog having the structure of 
       Formula I, II or II

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa at position 12 is lysine or arginine

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Asp, Glu, cysteic acid, homoglutamic acid 
       or homocysteic acid;

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Ser, glutamine, homoglutamic acid, 
       homocysteic acid, Thr or Aib

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa at position 21 is Asp, Lys, Cys, Orn, homocysteine or acetyl 
       phenylalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa at position 24 is Gln, Lys, Cys, Orn, homocysteine or acetyl 
       phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa at position 28 is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr, Lys, Arg, His, Gly, Asp or Glu

<400>  920

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  921
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is Ser, D-Ser, Ala, D-Ala, Gly, N-methyl-Ser, 
       AIB, Val, or alpha-amino-N-butyric acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa at position 12 is lysine or arginine

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Asp or Glu

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Ser, Thr or Aib

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa at position 21 is Asp, Lys, Cys, Orn, homocysteine or acetyl 
       phenylalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa at position 24 is Gln, Lys, Cys, Orn, homocysteine or acetyl 
       phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa at position 28 is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr, Lys, Arg, His, Gly, Asp or Glu

<400>  921

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  922
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is Ser, D-Ser, Ala, D-Ala, Gly, N-methyl-Ser, 
       AIB, Val, or alpha-amino-N-butyric acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa at position 12 is lysine or arginine

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Asp or Glu

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Ser, Thr or Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa at position 28 is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr, Lys, Arg, His, Gly, Asp or Glu

<400>  922

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  923
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is Ser, D-Ser, Ala, D-Ala, Gly, N-methyl-Ser, 
       AIB, Val, or alpha-amino-N-butyric acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa at position 12 is lysine or arginine

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Asp or Glu

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Ser, Thr or Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa at position 28 is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa at position 40 is Lys or Cys

<400>  923

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  924
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is Ser, D-Ser, Ala, D-Ala, Gly, N-methyl-Ser, 
       AIB, Val, or alpha-amino-N-butyric acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa at position 12 is lysine or arginine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa at position 28 is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa at position 40 is Lys or Cys

<400>  924

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  925
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is His, D-His, N-methyl-His, alpha-methyl-His, 
       imidazole acetic acid, des-amino-His, hydroxyl-His, acetyl-His, 
       homo-His, or alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is Ser, D-Ser, Ala, D-Ala, Gly, N-methyl-Ser, 
       AIB, Val, or alpha-amino-N-butyric acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa at position 3 is a glutamine analog having the structure of 
       Formula I, II or III

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Xaa at position 12 is lysine or arginine

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Asp, Glu, cysteic acid, homoglutamic acid 
       or homocysteic acid;

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa at position 21 is Asp, Lys, Cys, Orn, homocysteine or acetyl 
       phenylalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa at position 24 is Gln, Lys, Cys, Orn, homocysteine or acetyl 
       phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa at position 28 is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa at position 29 is Thr, Lys, Arg, His, Gly, Asp or Glu

<400>  925

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  926
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  926

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Lys 
1               5                   10      


<210>  927
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa at position 1 is His, D-His, N-methyl-His, alpha-methyl-His, 
       imidazole acetic acid, des-amino-His, hydroxyl-His, acetyl-His, 
       homo-His, or alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa at position 2 is Ser, D-Ser, Ala, D-Ala, Gly, N-methyl-Ser, 
       AIB, Val, or alpha-amino-N-butyric acid

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa at position 15 is Asp, Glu, cysteic acid, homoglutamic acid 
       or homocysteic acid;

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa at position 16 is Ser, glutamine, homoglutamic acid, 
       homocysteic acid, Thr or Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa at position 27 is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa at position 28 is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa at position 40 is Lys or Cys

<400>  927

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  928
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  928

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  929
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  929

Gly Pro Ser Ser Gly Ala Pro Pro Pro Lys 
1               5                   10  


<210>  930
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  930

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Lys 
1               5                   10      


<210>  931
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  931

Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10          


<210>  932
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  932

Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Lys 
1               5                   10              


<210>  933
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His or
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn, Nle of Gln derivative

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Lys or Arg

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Lys, Cys, Orn, homocystein or acetyl phenyalanine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Arg, His, Glu, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Arg, His, Asp or Glu

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  933

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Tyr Ser Xaa Tyr Leu Xaa 
1               5                   10                  15      


Ser Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  30  


<210>  934
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is dSer

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa at position 40 is Lys

<400>  934

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  935
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Aib or dSer

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa at position 40 is Lys or Cys

<400>  935

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


