                         SEQUENCE LISTING

<110>  Singapore Health Services Pte Ltd.
 
<120>  Use Of Biomarkers In Determining Susceptibility To Disease 
       Treatment

<130>  32644SG12

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Exon 18, forward primer

<400>  1
ctgaggtgac ccttgtctct gtgttctt                                          28


<210>  2
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Exon 18; reverse primer

<400>  2
agaggcctgt gccagggacc tta                                               23


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Exon 19; forward primer

<400>  3
tcactgggca gcatgtggca                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Exon 19; reverse primer

<400>  4
cagctgccag acatgagaaa                                                   20


<210>  5
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Exon 20; forward primer

<400>  5
ccatgcgaag ccacactga                                                    19


<210>  6
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Exon 20; reverse primer

<400>  6
cgtatctccc ttccctgatt acc                                               23


<210>  7
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Exon 21; forward primer

<400>  7
agcagggtct tctctgtttc a                                                 21


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Exon 21; reverse primer

<400>  8
tgacctaaag ccacctcctt                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR VIII; forward primer

<400>  9
gggctctgga ggaaaagaaa                                                   20


<210>  10
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR VIII; reverse primer

<400>  10
attccgttac acactttgcg gc                                                22


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neo ORF; forward primer

<400>  11
ctggctgcta ttgggcgaag                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Neo ORF; reverse primer

<400>  12
tgctggagta aaaggggctg                                                   20


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Copy; forward primer

<400>  13
ccaaggcacg agtaacaagc t                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Copy; reverse primer

<400>  14
gcacataggt aatttccaaa                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Actin (genomic); forward primer

<400>  15
gtccccttcc ctcctcagat                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Actin (genomic); reverse primer

<400>  16
cggactcgtc atactcctgc                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Isoform A; forward primer

<400>  17
actctgagtg catacagtgc                                                   20


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Isoform A; reverse primer

<400>  18
tcgttggaca gccttcaaga c                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Isoform D; forward primer

<400>  19
actctgagtg catacagtgc                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR Isoform D; reverse primer

<400>  20
tgaaggcatg aggctcagtg                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Actin (mRNA); forward primer

<400>  21
atgtttgaga ccttcacacc                                                   20


<210>  22
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Actin (mRNA); reverse primer

<400>  22
aggtagtcag tcaggtcccg g                                                 21


<210>  23
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR AS1; forward primer

<400>  23
tccaggtgaa gacgcatgaa                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR AS1; reverse primer

<400>  24
gtcttttgca ggcacagctt                                                   20


<210>  25
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LNA against EGFR-AS1 (LNA-AS1)

<400>  25
atcgcaaagg taatc                                                        15


<210>  26
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Negative control (LNA-i-miR-NC)

<400>  26
aacacgtcta tacgc                                                        15


<210>  27
<211>  6369
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EGFR as shown in NCBI sequence ID: NM_005228.4

<400>  27
gtccgggcag cccccggcgc agcgcggccg cagcagcctc cgccccccgc acggtgtgag       60

cgcccgacgc ggccgaggcg gccggagtcc cgagctagcc ccggcggccg ccgccgccca      120

gaccggacga caggccacct cgtcggcgtc cgcccgagtc cccgcctcgc cgccaacgcc      180

acaaccaccg cgcacggccc cctgactccg tccagtattg atcgggagag ccggagcgag      240

ctcttcgggg agcagcgatg cgaccctccg ggacggccgg ggcagcgctc ctggcgctgc      300

tggctgcgct ctgcccggcg agtcgggctc tggaggaaaa gaaagtttgc caaggcacga      360

gtaacaagct cacgcagttg ggcacttttg aagatcattt tctcagcctc cagaggatgt      420

tcaataactg tgaggtggtc cttgggaatt tggaaattac ctatgtgcag aggaattatg      480

atctttcctt cttaaagacc atccaggagg tggctggtta tgtcctcatt gccctcaaca      540

cagtggagcg aattcctttg gaaaacctgc agatcatcag aggaaatatg tactacgaaa      600

attcctatgc cttagcagtc ttatctaact atgatgcaaa taaaaccgga ctgaaggagc      660

tgcccatgag aaatttacag gaaatcctgc atggcgccgt gcggttcagc aacaaccctg      720

ccctgtgcaa cgtggagagc atccagtggc gggacatagt cagcagtgac tttctcagca      780

acatgtcgat ggacttccag aaccacctgg gcagctgcca aaagtgtgat ccaagctgtc      840

ccaatgggag ctgctggggt gcaggagagg agaactgcca gaaactgacc aaaatcatct      900

gtgcccagca gtgctccggg cgctgccgtg gcaagtcccc cagtgactgc tgccacaacc      960

agtgtgctgc aggctgcaca ggcccccggg agagcgactg cctggtctgc cgcaaattcc     1020

gagacgaagc cacgtgcaag gacacctgcc ccccactcat gctctacaac cccaccacgt     1080

accagatgga tgtgaacccc gagggcaaat acagctttgg tgccacctgc gtgaagaagt     1140

gtccccgtaa ttatgtggtg acagatcacg gctcgtgcgt ccgagcctgt ggggccgaca     1200

gctatgagat ggaggaagac ggcgtccgca agtgtaagaa gtgcgaaggg ccttgccgca     1260

aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata aatgctacga     1320

atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc ctgccggtgg     1380

catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa ctggatattc     1440

tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct gaaaacagga     1500

cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag caacatggtc     1560

agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc tccctcaagg     1620

agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat gcaaatacaa     1680

taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata agcaacagag     1740

gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc cccgagggct     1800

gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga ggcagggaat     1860

gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag aactctgagt     1920

gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc acaggacggg     1980

gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc gtcaagacct     2040

gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca gacgccggcc     2100

atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca ggtcttgaag     2160

gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg ggggccctcc     2220

tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gcgaaggcgc cacatcgttc     2280

ggaagcgcac gctgcggagg ctgctgcagg agagggagct tgtggagcct cttacaccca     2340

gtggagaagc tcccaaccaa gctctcttga ggatcttgaa ggaaactgaa ttcaaaaaga     2400

tcaaagtgct gggctccggt gcgttcggca cggtgtataa gggactctgg atcccagaag     2460

gtgagaaagt taaaattccc gtcgctatca aggaattaag agaagcaaca tctccgaaag     2520

ccaacaagga aatcctcgat gaagcctacg tgatggccag cgtggacaac ccccacgtgt     2580

gccgcctgct gggcatctgc ctcacctcca ccgtgcagct catcacgcag ctcatgccct     2640

tcggctgcct cctggactat gtccgggaac acaaagacaa tattggctcc cagtacctgc     2700

tcaactggtg tgtgcagatc gcaaagggca tgaactactt ggaggaccgt cgcttggtgc     2760

accgcgacct ggcagccagg aacgtactgg tgaaaacacc gcagcatgtc aagatcacag     2820

attttgggct ggccaaactg ctgggtgcgg aagagaaaga ataccatgca gaaggaggca     2880

aagtgcctat caagtggatg gcattggaat caattttaca cagaatctat acccaccaga     2940

gtgatgtctg gagctacggg gtgactgttt gggagttgat gacctttgga tccaagccat     3000

atgacggaat ccctgccagc gagatctcct ccatcctgga gaaaggagaa cgcctccctc     3060

agccacccat atgtaccatc gatgtctaca tgatcatggt caagtgctgg atgatagacg     3120

cagatagtcg cccaaagttc cgtgagttga tcatcgaatt ctccaaaatg gcccgagacc     3180

cccagcgcta ccttgtcatt cagggggatg aaagaatgca tttgccaagt cctacagact     3240

ccaacttcta ccgtgccctg atggatgaag aagacatgga cgacgtggtg gatgccgacg     3300

agtacctcat cccacagcag ggcttcttca gcagcccctc cacgtcacgg actcccctcc     3360

tgagctctct gagtgcaacc agcaacaatt ccaccgtggc ttgcattgat agaaatgggc     3420

tgcaaagctg tcccatcaag gaagacagct tcttgcagcg atacagctca gaccccacag     3480

gcgccttgac tgaggacagc atagacgaca ccttcctccc agtgcctgaa tacataaacc     3540

agtccgttcc caaaaggccc gctggctctg tgcagaatcc tgtctatcac aatcagcctc     3600

tgaaccccgc gcccagcaga gacccacact accaggaccc ccacagcact gcagtgggca     3660

accccgagta tctcaacact gtccagccca cctgtgtcaa cagcacattc gacagccctg     3720

cccactgggc ccagaaaggc agccaccaaa ttagcctgga caaccctgac taccagcagg     3780

acttctttcc caaggaagcc aagccaaatg gcatctttaa gggctccaca gctgaaaatg     3840

cagaatacct aagggtcgcg ccacaaagca gtgaatttat tggagcatga ccacggagga     3900

tagtatgagc cctaaaaatc cagactcttt cgatacccag gaccaagcca cagcaggtcc     3960

tccatcccaa cagccatgcc cgcattagct cttagaccca cagactggtt ttgcaacgtt     4020

tacaccgact agccaggaag tacttccacc tcgggcacat tttgggaagt tgcattcctt     4080

tgtcttcaaa ctgtgaagca tttacagaaa cgcatccagc aagaatattg tccctttgag     4140

cagaaattta tctttcaaag aggtatattt gaaaaaaaaa aaaagtatat gtgaggattt     4200

ttattgattg gggatcttgg agtttttcat tgtcgctatt gatttttact tcaatgggct     4260

cttccaacaa ggaagaagct tgctggtagc acttgctacc ctgagttcat ccaggcccaa     4320

ctgtgagcaa ggagcacaag ccacaagtct tccagaggat gcttgattcc agtggttctg     4380

cttcaaggct tccactgcaa aacactaaag atccaagaag gccttcatgg ccccagcagg     4440

ccggatcggt actgtatcaa gtcatggcag gtacagtagg ataagccact ctgtcccttc     4500

ctgggcaaag aagaaacgga ggggatggaa ttcttcctta gacttacttt tgtaaaaatg     4560

tccccacggt acttactccc cactgatgga ccagtggttt ccagtcatga gcgttagact     4620

gacttgtttg tcttccattc cattgttttg aaactcagta tgctgcccct gtcttgctgt     4680

catgaaatca gcaagagagg atgacacatc aaataataac tcggattcca gcccacattg     4740

gattcatcag catttggacc aatagcccac agctgagaat gtggaatacc taaggatagc     4800

accgcttttg ttctcgcaaa aacgtatctc ctaatttgag gctcagatga aatgcatcag     4860

gtcctttggg gcatagatca gaagactaca aaaatgaagc tgctctgaaa tctcctttag     4920

ccatcacccc aaccccccaa aattagtttg tgttacttat ggaagatagt tttctccttt     4980

tacttcactt caaaagcttt ttactcaaag agtatatgtt ccctccaggt cagctgcccc     5040

caaaccccct ccttacgctt tgtcacacaa aaagtgtctc tgccttgagt catctattca     5100

agcacttaca gctctggcca caacagggca ttttacaggt gcgaatgaca gtagcattat     5160

gagtagtgtg gaattcaggt agtaaatatg aaactagggt ttgaaattga taatgctttc     5220

acaacatttg cagatgtttt agaaggaaaa aagttccttc ctaaaataat ttctctacaa     5280

ttggaagatt ggaagattca gctagttagg agcccacctt ttttcctaat ctgtgtgtgc     5340

cctgtaacct gactggttaa cagcagtcct ttgtaaacag tgttttaaac tctcctagtc     5400

aatatccacc ccatccaatt tatcaaggaa gaaatggttc agaaaatatt ttcagcctac     5460

agttatgttc agtcacacac acatacaaaa tgttcctttt gcttttaaag taatttttga     5520

ctcccagatc agtcagagcc cctacagcat tgttaagaaa gtatttgatt tttgtctcaa     5580

tgaaaataaa actatattca tttccactct attatgctct caaatacccc taagcatcta     5640

tactagcctg gtatgggtat gaaagataca aagataaata aaacatagtc cctgattcta     5700

agaaattcac aatttagcaa aggaaatgga ctcatagatg ctaaccttaa aacaacgtga     5760

caaatgccag acaggaccca tcagccaggc actgtgagag cacagagcag ggaggttggg     5820

tcctgcctga ggagacctgg aagggaggcc tcacaggagg atgaccaggt ctcagtcagc     5880

ggggaggtgg aaagtgcagg tgcatcaggg gcaccctgac cgaggaaaca gctgccagag     5940

gcctccactg ctaaagtcca cataaggctg aggtcagtca ccctaaacaa cctgctccct     6000

ctaagccagg ggatgagctt ggagcatccc acaagttccc taaaagttgc agcccccagg     6060

gggattttga gctatcatct ctgcacatgc ttagtgagaa gactacacaa catttctaag     6120

aatctgagat tttatattgt cagttaacca ctttcattat tcattcacct caggacatgc     6180

agaaatattt cagtcagaac tgggaaacag aaggacctac attctgctgt cacttatgtg     6240

tcaagaagca gatgatcgat gaggcaggtc agttgtaagt gagtcacatt gtagcattaa     6300

attctagtat ttttgtagtt tgaaacagta acttaataaa agagcaaaag ctaaaaaaaa     6360

aaaaaaaaa                                                             6369


