                         SEQUENCE LISTING

<110>  Tudzarova-Trajkovska, Slavica
       Butler, Peter
 
<120>  METHODS OF TREATING DISEASE WITH PFKFB3 INHIBITORS

<130>  UCLA.P0030WO

<140>  Unknown
<141>  2016-05-31

<150>  62/343,377
<151>  2016-05-31

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  4226
<212>  DNA
<213>  Homo sapiens

<400>  1
ccctttcccc tccctcgccc gccccgccgc ccgcaggcgc cccgagtcgc ggggctgccg       60

cttggacgtc gtcctgtctg ggtgtcgcgg gccggccccg cggggagcgc ccccggcgcg      120

atgcccttca ggaaagcctg tgggccaaag ctgaccaact cccccaccgt catcgtcatg      180

gtgggcctcc ccgcccgggg caagacctac atctccaaga agctgactcg ctacctcaac      240

tggattggcg tccccacaaa agtgttcaac gtcggggagt atcgccggga ggctgtgaag      300

cagtacagct cctacaactt cttccgcccc gacaatgagg aagccatgaa agtccggaag      360

caatgtgcct tagctgcctt gagagatgtc aaaagctacc tggcgaaaga agggggacaa      420

attgcggttt tcgatgccac caatactact agagagagga gacacatgat ccttcatttt      480

gccaaagaaa atgactttaa ggcgtttttc atcgagtcgg tgtgcgacga ccctacagtt      540

gtggcctcca atatcatgga agttaaaatc tccagcccgg attacaaaga ctgcaactcg      600

gcagaagcca tggacgactt catgaagagg atcagttgct atgaagccag ctaccagccc      660

ctcgaccccg acaaatgcga cagggacttg tcgctgatca aggtgattga cgtgggccgg      720

aggttcctgg tgaaccgggt gcaggaccac atccagagcc gcatcgtgta ctacctgatg      780

aacatccacg tgcagccgcg taccatctac ctgtgccggc acggcgagaa cgagcacaac      840

ctccagggcc gcatcggggg cgactcaggc ctgtccagcc ggggcaagaa gtttgccagt      900

gctctgagca agttcgtgga ggagcagaac ctgaaggacc tgcgcgtgtg gaccagccag      960

ctgaagagca ccatccagac ggccgaggcg ctgcggctgc cctacgagca gtggaaggcg     1020

ctcaatgaga tcgacgcggg cgtctgtgag gagctgacct acgaggagat cagggacacc     1080

taccctgagg agtatgcgct gcgggagcag gacaagtact attaccgcta ccccaccggg     1140

gagtcctacc aggacctggt ccagcgcttg gagccagtga tcatggagct ggagcggcag     1200

gagaatgtgc tggtcatctg ccaccaggcc gtcctgcgct gcctgcttgc ctacttcctg     1260

gataagagtg cagaggagat gccctacctg aaatgccctc ttcacaccgt cctgaaactg     1320

acgcctgtcg cttatggctg ccgtgtggaa tccatctacc tgaacgtgga gtccgtctgc     1380

acacaccggg agaggtcaga ggatgcaaag aagggaccta acccgctcat gagacgcaat     1440

agtgtcaccc cgctagccag ccccgaaccc accaaaaagc ctcgcatcaa cagctttgag     1500

gagcatgtgg cctccacctc ggccgccctg cccagctgcc tgcccccgga ggtgcccacg     1560

cagctgcctg gacaaaacat gaaaggctcc cggagcagcg ctgactcctc caggaaacac     1620

tgaggcagac gtgtcggttc cattccattt ccatttctgc agcttagctt gtgtcctgcc     1680

ctccgcccga ggcaaaacgt atcctgagga cttcttccgg agagggtggg gtggagcagc     1740

gggggagcct tggccgaaga gaaccatgct tggcaccgtc tgtgtcccct cggccgctgg     1800

acaccagaaa gccacgtggg tccctggcgc cctgccttta gccgtggggc ccccacctcc     1860

actctctggg tttcctagga atgtccagcc tcggagacct tcacaaagcc ttgggagggt     1920

gatgagtgct ggtcctgaca ggaggccgct ggggacactg tgctgttttg tttcgtttct     1980

gtgatctccc ggcacgtttg gagctgggaa gaccacactg gtggcagaat cctaaaatta     2040

aaggaggcag gctcctagtt gctgaaagtt aaggaatgtg taaaacctcc acgtgactgt     2100

ttggtgcatc ttgacctggg aagacgcctc atgggaacga acttggacag gtgttgggtt     2160

gaggcctctt ctgcaggaag tccctgagct gagacgcaag ttggctgggt ggtccgcacc     2220

ctggctctcc tgcaggtcca cacaccttcc aggcctgtgg cctgcctcca aagatgtgca     2280

agggcaggct ggctgcacgg ggagagggaa gtattttgcc gaaatatgag aactggggcc     2340

tcctgctccc agggagctcc agggcccctc tctcctccca cctggacttg gggggaactg     2400

agaaacactt tcctggagct gctggctttt gcactttttt gatggcagaa gtgtgacctg     2460

agagtcccac cttctcttca ggaacgtaga tgttggggtg tcttgccctg gggggcttgg     2520

aacctctgaa ggtggggagc ggaacacctg gcatccttcc ccagcacttg cattaccgtc     2580

cctgctcttc ccaggtgggg acagtggccc aagcaaggcc tcactcgcag ccacttcttc     2640

aagagctgcc tgcacactgt cttggagcat ctgccttgtg cctggcactc tgccggtgcc     2700

ttgggaaggt cggaagagtg gactttgtcc tggccttccc ttcatggcgt ctatgacact     2760

tttgtggtga tggaaagcat gggacctgtc gtctcagcct gttggtttct cctcattgcc     2820

tcaaaccctg gggtaggtgg gacggggggt ctcgtgccca gatgaaacca tttggaaact     2880

cggcagcaga gtttgtccaa atgacccttt tcaggatgtc tcaaagcttg tgccaaaggt     2940

cacttttctt tcctgccttc tgctgtgagc cctgagatcc tcctcccagc tcaagggaca     3000

ggtcctgggt gagggtggga gatttagaca cctgaaactg ggcgtggaga gaagagccgt     3060

tgctgtttgt tttttgggaa gagcttttaa agaatgcatg tttttttcct ggttggaatt     3120

gagtaggaac tgaggctgtg cttcaggtat ggtacaatca agtgggggat tttcatgctg     3180

aaccattcaa gccctccccg cccgttgcac ccactttggc tggcgtctgc tggagaggat     3240

gtctctgtcc gcattcccgt gcagctccag gctcgcgcag ttttctctct ctccctggat     3300

gttgagtctc atcagaatat gtgggtaggg ggtggacgtg cacgggtgca tgattgtgct     3360

taacttggtt gtatttttcg atttgacatg gaaggcctgt tgctttgctc ttgagaatag     3420

tttctcgtgt ccccctcgca ggcctcattc tttgaacatc gactctgaag tttgatacag     3480

ataggggctt gatagctgtg gtcccctctc ccctctgact acctaaaatc aatacctaaa     3540

tacagaagcc ttggtctaac acgggacttt tagtttgcga agggcctaga tagggagaga     3600

ggtaacatga atctggacag ggagggagat actatagaaa ggagaacact gcctactttg     3660

caagccagtg acctgccttt tgaggggaca ttggacgggg gccgggggcg ggggttgggt     3720

ttgagctaca gtcatgaact tttggcgtct actgattcct ccaactctcc accccacaaa     3780

ataacgggga ccaatatttt taactttgcc tatttgtttt tgggtgagtt tcccccctcc     3840

ttattctgtc ctgagaccac gggcaaagct cttcattttg agagagaaga aaaactgttt     3900

ggaaccacac caatgatatt tttctttgta atacttgaaa tttatttttt tattattttg     3960

atagcagatg tgctatttat ttatttaata tgtataagga gcctaaacaa tagaaagctg     4020

tagagattgg gtttcattgt taattggttt gggagcctcc tatgtgtgac ttatgacttc     4080

tctgtgttct gtgtatttgt ctgaattaat gacctgggat ataaagctat gctagctttc     4140

aaacaggaga tgcctttcag aaatttgtat attttgcagt tgccagacca ataaaatacc     4200

tggttgaaat acatggacga agtaaa                                          4226


<210>  2
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Phe Arg Lys Ala Cys Gly Pro Lys Leu Thr Asn Ser Pro Thr 
1               5                   10                  15      


Val Ile Val Met Val Gly Leu Pro Ala Arg Gly Lys Thr Tyr Ile Ser 
            20                  25                  30          


Lys Lys Leu Thr Arg Tyr Leu Asn Trp Ile Gly Val Pro Thr Lys Val 
        35                  40                  45              


Phe Asn Val Gly Glu Tyr Arg Arg Glu Ala Val Lys Gln Tyr Ser Ser 
    50                  55                  60                  


Tyr Asn Phe Phe Arg Pro Asp Asn Glu Glu Ala Met Lys Val Arg Lys 
65                  70                  75                  80  


Gln Cys Ala Leu Ala Ala Leu Arg Asp Val Lys Ser Tyr Leu Ala Lys 
                85                  90                  95      


Glu Gly Gly Gln Ile Ala Val Phe Asp Ala Thr Asn Thr Thr Arg Glu 
            100                 105                 110         


Arg Arg His Met Ile Leu His Phe Ala Lys Glu Asn Asp Phe Lys Ala 
        115                 120                 125             


Phe Phe Ile Glu Ser Val Cys Asp Asp Pro Thr Val Val Ala Ser Asn 
    130                 135                 140                 


Ile Met Glu Val Lys Ile Ser Ser Pro Asp Tyr Lys Asp Cys Asn Ser 
145                 150                 155                 160 


Ala Glu Ala Met Asp Asp Phe Met Lys Arg Ile Ser Cys Tyr Glu Ala 
                165                 170                 175     


Ser Tyr Gln Pro Leu Asp Pro Asp Lys Cys Asp Arg Asp Leu Ser Leu 
            180                 185                 190         


Ile Lys Val Ile Asp Val Gly Arg Arg Phe Leu Val Asn Arg Val Gln 
        195                 200                 205             


Asp His Ile Gln Ser Arg Ile Val Tyr Tyr Leu Met Asn Ile His Val 
    210                 215                 220                 


Gln Pro Arg Thr Ile Tyr Leu Cys Arg His Gly Glu Asn Glu His Asn 
225                 230                 235                 240 


Leu Gln Gly Arg Ile Gly Gly Asp Ser Gly Leu Ser Ser Arg Gly Lys 
                245                 250                 255     


Lys Phe Ala Ser Ala Leu Ser Lys Phe Val Glu Glu Gln Asn Leu Lys 
            260                 265                 270         


Asp Leu Arg Val Trp Thr Ser Gln Leu Lys Ser Thr Ile Gln Thr Ala 
        275                 280                 285             


Glu Ala Leu Arg Leu Pro Tyr Glu Gln Trp Lys Ala Leu Asn Glu Ile 
    290                 295                 300                 


Asp Ala Gly Val Cys Glu Glu Leu Thr Tyr Glu Glu Ile Arg Asp Thr 
305                 310                 315                 320 


Tyr Pro Glu Glu Tyr Ala Leu Arg Glu Gln Asp Lys Tyr Tyr Tyr Arg 
                325                 330                 335     


Tyr Pro Thr Gly Glu Ser Tyr Gln Asp Leu Val Gln Arg Leu Glu Pro 
            340                 345                 350         


Val Ile Met Glu Leu Glu Arg Gln Glu Asn Val Leu Val Ile Cys His 
        355                 360                 365             


Gln Ala Val Leu Arg Cys Leu Leu Ala Tyr Phe Leu Asp Lys Ser Ala 
    370                 375                 380                 


Glu Glu Met Pro Tyr Leu Lys Cys Pro Leu His Thr Val Leu Lys Leu 
385                 390                 395                 400 


Thr Pro Val Ala Tyr Gly Cys Arg Val Glu Ser Ile Tyr Leu Asn Val 
                405                 410                 415     


Glu Ser Val Cys Thr His Arg Glu Arg Ser Glu Asp Ala Lys Lys Gly 
            420                 425                 430         


Pro Asn Pro Leu Met Arg Arg Asn Ser Val Thr Pro Leu Ala Ser Pro 
        435                 440                 445             


Glu Pro Thr Lys Lys Pro Arg Ile Asn Ser Phe Glu Glu His Val Ala 
    450                 455                 460                 


Ser Thr Ser Ala Ala Leu Pro Ser Cys Leu Pro Pro Glu Val Pro Thr 
465                 470                 475                 480 


Gln Leu Pro Gly Gln Asn Met Lys Gly Ser Arg Ser Ser Ala Asp Ser 
                485                 490                 495     


Ser Arg Lys His 
            500 


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  3
cacggcgaga atgagtacaa                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  4
ttcagctgac tggtccacac                                                   20


<210>  5
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  5
tgctggagcc actgtcg                                                      17


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  6
ctgggtttga gacgatgagc                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  7
atgtatgccg gaggtcctat c                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  8
ccaatggtcg cttcttgtag a                                                 21


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  9
atgactctac ccacggcaag                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  10
ctggaagatg gtgatgggtt                                                   20


