                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  CELL

<130>  P109339PCT

<150>  GB 1609604.2
<151>  2016-06-01

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Tyr Asn Gly Ser Cys Cys Arg Ile Glu Gly Asp Thr Ile Ser Gln 
1               5                   10                  15      


Val Met Pro Pro Leu Leu Ile Val Ala Phe Val Leu Gly Ala Leu Gly 
            20                  25                  30          


Asn Gly Val Ala Leu Cys Gly Phe Cys Phe His Met Lys Thr Trp Lys 
        35                  40                  45              


Pro Ser Thr Val Tyr Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu 
    50                  55                  60                  


Met Ile Cys Leu Pro Phe Arg Thr Asp Tyr Tyr Leu Arg Arg Arg His 
65                  70                  75                  80  


Trp Ala Phe Gly Asp Ile Pro Cys Arg Val Gly Leu Phe Thr Leu Ala 
                85                  90                  95      


Met Asn Arg Ala Gly Ser Ile Val Phe Leu Thr Val Val Ala Ala Asp 
            100                 105                 110         


Arg Tyr Phe Lys Val Val His Pro His His Ala Val Asn Thr Ile Ser 
        115                 120                 125             


Thr Arg Val Ala Ala Gly Ile Val Cys Thr Leu Trp Ala Leu Val Ile 
    130                 135                 140                 


Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln Glu 
145                 150                 155                 160 


Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly Trp 
                165                 170                 175     


His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile Ile 
            180                 185                 190         


Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln Gln 
        195                 200                 205             


Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met Val 
    210                 215                 220                 


Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala Arg 
225                 230                 235                 240 


Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser Val 
                245                 250                 255     


His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met 
            260                 265                 270         


Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys Phe 
        275                 280                 285             


Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly His 
    290                 295                 300                 


Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly Arg 
305                 310                 315                 320 


Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp Gly 
                325                 330                 335     


Gln Trp Asp Pro His Ile Val Glu Trp His 
            340                 345     


<210>  2
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Asn His Thr Trp Glu Gly Cys His Val Asp Ser Arg Val Asp 
1               5                   10                  15      


His Leu Phe Pro Pro Ser Leu Tyr Ile Phe Val Ile Gly Val Gly Leu 
            20                  25                  30          


Pro Thr Asn Cys Leu Ala Leu Trp Ala Ala Tyr Arg Gln Val Gln Gln 
        35                  40                  45              


Arg Asn Glu Leu Gly Val Tyr Leu Met Asn Leu Ser Ile Ala Asp Leu 
    50                  55                  60                  


Leu Tyr Ile Cys Thr Leu Pro Leu Trp Val Asp Tyr Phe Leu His His 
65                  70                  75                  80  


Asp Asn Trp Ile His Gly Pro Gly Ser Cys Lys Leu Phe Gly Phe Ile 
                85                  90                  95      


Phe Tyr Thr Asn Ile Tyr Ile Ser Ile Ala Phe Leu Cys Cys Ile Ser 
            100                 105                 110         


Val Asp Arg Tyr Leu Ala Val Ala His Pro Leu Arg Phe Ala Arg Leu 
        115                 120                 125             


Arg Arg Val Lys Thr Ala Val Ala Val Ser Ser Val Val Trp Ala Thr 
    130                 135                 140                 


Glu Leu Gly Ala Asn Ser Ala Pro Leu Phe His Asp Glu Leu Phe Arg 
145                 150                 155                 160 


Asp Arg Tyr Asn His Thr Phe Cys Phe Glu Lys Phe Pro Met Glu Gly 
                165                 170                 175     


Trp Val Ala Trp Met Asn Leu Tyr Arg Val Phe Val Gly Phe Leu Phe 
            180                 185                 190         


Pro Trp Ala Leu Met Leu Leu Ser Tyr Arg Gly Ile Leu Arg Ala Val 
        195                 200                 205             


Arg Gly Ser Val Ser Thr Glu Arg Gln Glu Lys Ala Lys Ile Lys Arg 
    210                 215                 220                 


Leu Ala Leu Ser Leu Ile Ala Ile Val Leu Val Cys Phe Ala Pro Tyr 
225                 230                 235                 240 


His Val Leu Leu Leu Ser Arg Ser Ala Ile Tyr Leu Gly Arg Pro Trp 
                245                 250                 255     


Asp Cys Gly Phe Glu Glu Arg Val Phe Ser Ala Tyr His Ser Ser Leu 
            260                 265                 270         


Ala Phe Thr Ser Leu Asn Cys Val Ala Asp Pro Ile Leu Tyr Cys Leu 
        275                 280                 285             


Val Asn Glu Gly Ala Arg Ser Asp Val Ala Lys Ala Leu His Asn Leu 
    290                 295                 300                 


Leu Arg Phe Leu Ala Ser Asp Lys Pro Gln Glu Met Ala Asn Ala Ser 
305                 310                 315                 320 


Leu Thr Leu Glu Thr Pro Leu Thr Ser Lys Arg Asn Ser Thr Ala Lys 
                325                 330                 335     


Ala Met Thr Gly Ser Trp Ala Ala Thr Pro Pro Ser Gln Gly Asp Gln 
            340                 345                 350         


Val Gln Leu Lys Met Leu Pro Pro Ala Gln 
        355                 360         


<210>  3
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Asn Ile Thr Ala Asp Asn Ser Ser Met Ser Cys Thr Ile Asp 
1               5                   10                  15      


His Thr Ile His Gln Thr Leu Ala Pro Val Val Tyr Val Thr Val Leu 
            20                  25                  30          


Val Val Gly Phe Pro Ala Asn Cys Leu Ser Leu Tyr Phe Gly Tyr Leu 
        35                  40                  45              


Gln Ile Lys Ala Arg Asn Glu Leu Gly Val Tyr Leu Cys Asn Leu Thr 
    50                  55                  60                  


Val Ala Asp Leu Phe Tyr Ile Cys Ser Leu Pro Phe Trp Leu Gln Tyr 
65                  70                  75                  80  


Val Leu Gln His Asp Asn Trp Ser His Gly Asp Leu Ser Cys Gln Val 
                85                  90                  95      


Cys Gly Ile Leu Leu Tyr Glu Asn Ile Tyr Ile Ser Val Gly Phe Leu 
            100                 105                 110         


Cys Cys Ile Ser Val Asp Arg Tyr Leu Ala Val Ala His Pro Phe Arg 
        115                 120                 125             


Phe His Gln Phe Arg Thr Leu Lys Ala Ala Val Gly Val Ser Val Val 
    130                 135                 140                 


Ile Trp Ala Lys Glu Leu Leu Thr Ser Ile Tyr Phe Leu Met His Glu 
145                 150                 155                 160 


Glu Val Ile Glu Asp Glu Asn Gln His Arg Val Cys Phe Glu His Tyr 
                165                 170                 175     


Pro Ile Gln Ala Trp Gln Arg Ala Ile Asn Tyr Tyr Arg Phe Leu Val 
            180                 185                 190         


Gly Phe Leu Phe Pro Ile Cys Leu Leu Leu Ala Ser Tyr Gln Gly Ile 
        195                 200                 205             


Leu Arg Ala Val Arg Arg Ser His Gly Thr Gln Lys Ser Arg Lys Asp 
    210                 215                 220                 


Gln Ile Gln Arg Leu Val Leu Ser Thr Val Val Ile Phe Leu Ala Cys 
225                 230                 235                 240 


Phe Leu Pro Tyr His Val Leu Leu Leu Val Arg Ser Val Trp Glu Ala 
                245                 250                 255     


Ser Cys Asp Phe Ala Lys Gly Val Phe Asn Ala Tyr His Phe Ser Leu 
            260                 265                 270         


Leu Leu Thr Ser Phe Asn Cys Val Ala Asp Pro Val Leu Tyr Cys Phe 
        275                 280                 285             


Val Ser Glu Thr Thr His Arg Asp Leu Ala Arg Leu Arg Gly Ala Cys 
    290                 295                 300                 


Leu Ala Phe Leu Thr Cys Ser Arg Thr Gly Arg Ala Arg Glu Ala Tyr 
305                 310                 315                 320 


Pro Leu Gly Ala Pro Glu Ala Ser Gly Lys Ser Gly Ala Gln Gly Glu 
                325                 330                 335     


Glu Pro Glu Leu Leu Thr Lys Leu His Pro Ala Phe Gln Thr Pro Asn 
            340                 345                 350         


Ser Pro Gly Ser Gly Gly Phe Pro Thr Gly Arg Leu Ala 
        355                 360                 365 


<210>  4
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Ser Thr Cys Ile Glu Glu Gln His Asp Leu Asp His Tyr Leu 
1               5                   10                  15      


Phe Pro Ile Val Tyr Ile Phe Val Ile Ile Val Ser Ile Pro Ala Asn 
            20                  25                  30          


Ile Gly Ser Leu Cys Val Ser Phe Leu Gln Ala Lys Lys Glu Ser Glu 
        35                  40                  45              


Leu Gly Ile Tyr Leu Phe Ser Leu Ser Leu Ser Asp Leu Leu Tyr Ala 
    50                  55                  60                  


Leu Thr Leu Pro Leu Trp Ile Asp Tyr Thr Trp Asn Lys Asp Asn Trp 
65                  70                  75                  80  


Thr Phe Ser Pro Ala Leu Cys Lys Gly Ser Ala Phe Leu Met Tyr Met 
                85                  90                  95      


Asn Phe Tyr Ser Ser Thr Ala Phe Leu Thr Cys Ile Ala Val Asp Arg 
            100                 105                 110         


Tyr Leu Ala Val Val Tyr Pro Leu Lys Phe Phe Phe Leu Arg Thr Arg 
        115                 120                 125             


Arg Phe Ala Leu Met Val Ser Leu Ser Ile Trp Ile Leu Glu Thr Ile 
    130                 135                 140                 


Phe Asn Ala Val Met Leu Trp Glu Asp Glu Thr Val Val Glu Tyr Cys 
145                 150                 155                 160 


Asp Ala Glu Lys Ser Asn Phe Thr Leu Cys Tyr Asp Lys Tyr Pro Leu 
                165                 170                 175     


Glu Lys Trp Gln Ile Asn Leu Asn Leu Phe Arg Thr Cys Thr Gly Tyr 
            180                 185                 190         


Ala Ile Pro Leu Val Thr Ile Leu Ile Cys Asn Arg Lys Val Tyr Gln 
        195                 200                 205             


Ala Val Arg His Asn Lys Ala Thr Glu Asn Lys Glu Lys Lys Arg Ile 
    210                 215                 220                 


Ile Lys Leu Leu Val Ser Ile Thr Val Thr Phe Val Leu Cys Phe Thr 
225                 230                 235                 240 


Pro Phe His Val Met Leu Leu Ile Arg Cys Ile Leu Glu His Ala Val 
                245                 250                 255     


Asn Phe Glu Asp His Ser Asn Ser Gly Lys Arg Thr Tyr Thr Met Tyr 
            260                 265                 270         


Arg Ile Thr Val Ala Leu Thr Ser Leu Asn Cys Val Ala Asp Pro Ile 
        275                 280                 285             


Leu Tyr Cys Phe Val Thr Glu Thr Gly Arg Tyr Asp Met Trp Asn Ile 
    290                 295                 300                 


Leu Lys Phe Cys Thr Gly Arg Cys Asn Thr Ser Gln Arg Gln Arg Lys 
305                 310                 315                 320 


Arg Ile Leu Ser Val Ser Thr Lys Asp Thr Met Glu Leu Glu Val Leu 
                325                 330                 335     


Glu 
    


<210>  5
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GAL4 DNA binding domain

<400>  5

Met Arg Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg 
1               5                   10                  15      


Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys 
            20                  25                  30          


Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser 
        35                  40                  45              


Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg 
    50                  55                  60                  


Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met 
65                  70                  75                  80  


Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly 
                85                  90                  95      


Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu 
            100                 105                 110         


Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile 
        115                 120                 125             


Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln 
    130                 135                 140                 


Leu Thr Val 
145         


<210>  6
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  upstream activating sequence (UAS)


<220>
<221>  misc_feature
<222>  (4)..(14)
<223>  n is a, c, g, or t

<400>  6
cggnnnnnnn nnnnccg                                                      17


<210>  7
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transcriptional activator VP16

<400>  7

Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly 
1               5                   10                  15      


Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu 
            20                  25                  30          


Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His 
        35                  40                  45              


Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu 
    50                  55                  60                  


Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
65                  70                  75              


<210>  8
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transcriptional activator p65

<400>  8

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg 
    290                 295                 300                 


Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly 
305                 310                 315                 320 


Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg 
                325                 330                 335     


Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr 
            340                 345                 350         


Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe 
        355                 360                 365             


Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro 
    370                 375                 380                 


Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val 
385                 390                 395                 400 


Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly 
                405                 410                 415     


Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly 
            420                 425                 430         


Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu 
        435                 440                 445             


Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr 
    450                 455                 460                 


Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln 
465                 470                 475                 480 


Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr 
                485                 490                 495     


Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp 
            500                 505                 510         


Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu 
        515                 520                 525             


Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala 
    530                 535                 540                 


Leu Leu Ser Gln Ile Ser Ser 
545                 550     


<210>  9
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transcriptional repressor SSX3

<400>  9

Met Asn Gly Asp Asp Thr Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Val Ser Glu Lys Ile Val Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Ile Leu Pro Ser Phe Met Arg Asn Lys Arg Val Thr Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Phe Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Gln Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Phe Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Val Ser Lys Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Gln Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile Asn Met Ile Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Glu His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp Glu 
            180                 185             


<210>  10
<211>  962
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transcriptional repressor V-Erb-A

<400>  10

Met Glu Thr Val Ile Lys Val Ile Ser Ser Ala Pro Val Val Ala Met 
1               5                   10                  15      


Pro Val Val Ile Lys Thr Glu Gly Pro Ala Trp Thr Pro Leu Glu Pro 
            20                  25                  30          


Glu Asp Thr Arg Trp Leu Asp Gly Lys His Lys Arg Lys Ser Ser Gln 
        35                  40                  45              


Cys Leu Val Lys Ser Ser Met Ser Gly Tyr Ile Pro Ser Cys Leu Asp 
    50                  55                  60                  


Lys Asp Glu Gln Cys Val Val Cys Gly Asp Lys Pro Thr Gly Tyr His 
65                  70                  75                  80  


Tyr Arg Cys Ile Thr Cys Glu Gly Cys Lys Ser Phe Phe Arg Arg Thr 
                85                  90                  95      


Ile Gln Lys Asn Leu His Pro Thr Tyr Ser Cys Thr Tyr Asp Gly Cys 
            100                 105                 110         


Cys Val Ile Asp Lys Ile Thr Arg Asn Gln Cys Gln Leu Cys Arg Phe 
        115                 120                 125             


Lys Lys Cys Ile Ser Val Gly Met Ala Met Asp Leu Val Leu Asp Asp 
    130                 135                 140                 


Ser Lys Arg Val Ala Lys Arg Lys Leu Ile Glu Glu Asn Arg Glu Arg 
145                 150                 155                 160 


Arg Arg Lys Glu Glu Met Ile Lys Ser Leu Gln His Arg Pro Ser Pro 
                165                 170                 175     


Ser Ala Glu Glu Trp Glu Leu Ile His Val Val Thr Glu Ala His Arg 
            180                 185                 190         


Ser Thr Asn Ala Gln Gly Ser His Trp Lys Gln Arg Arg Lys Phe Leu 
        195                 200                 205             


Leu Glu Asp Ile Gly Gln Ser Pro Met Ala Ser Met Leu Asp Gly Asp 
    210                 215                 220                 


Lys Val Asp Leu Glu Ala Phe Thr Glu Phe Thr Lys Ile Ile Thr Pro 
225                 230                 235                 240 


Ala Ile Thr Arg Val Val Asp Phe Ala Lys Asn Leu Pro Met Phe Ser 
                245                 250                 255     


Glu Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met 
            260                 265                 270         


Glu Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu 
        275                 280                 285             


Thr Leu Thr Leu Ser Gly Glu Met Ala Val Lys Arg Glu Gln Leu Lys 
    290                 295                 300                 


Asn Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Lys 
305                 310                 315                 320 


Ser Leu Ser Ala Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln 
                325                 330                 335     


Ala Val Leu Leu Met Ser Ser Asp Arg Thr Gly Leu Ile Cys Val Asp 
            340                 345                 350         


Lys Ile Glu Lys Cys Gln Glu Ser Tyr Leu Leu Ala Phe Glu His Tyr 
        355                 360                 365             


Ile Asn Tyr Arg Lys His Asn Ile Pro His Phe Trp Ser Lys Leu Leu 
    370                 375                 380                 


Met Lys Val Ala Asp Leu Arg Met Ile Gly Ala Tyr His Ala Ser Arg 
385                 390                 395                 400 


Phe Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Ser Pro Gln Glu 
                405                 410                 415     


Val Gly Pro Asp His Cys Met Lys Cys Ala His Phe Ile Asp Gly Pro 
            420                 425                 430         


His Cys Val Lys Ala Cys Pro Ala Gly Val Leu Gly Glu Asn Asp Thr 
        435                 440                 445             


Leu Val Trp Lys Tyr Ala Asp Ala Asn Ala Val Cys Gln Leu Cys His 
    450                 455                 460                 


Pro Asn Cys Thr Arg Gly Cys Lys Gly Pro Gly Leu Glu Gly Cys Pro 
465                 470                 475                 480 


Asn Gly Ser Lys Thr Pro Ser Ile Ala Ala Gly Val Val Gly Gly Leu 
                485                 490                 495     


Leu Cys Leu Val Val Val Gly Leu Gly Ile Gly Leu Tyr Leu Arg Arg 
            500                 505                 510         


Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg 
        515                 520                 525             


Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala 
    530                 535                 540                 


His Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Val Lys Val Leu 
545                 550                 555                 560 


Gly Phe Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu 
                565                 570                 575     


Gly Glu Lys Val Thr Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala 
            580                 585                 590         


Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met 
        595                 600                 605             


Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu 
    610                 615                 620                 


Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Tyr Gly Cys Leu 
625                 630                 635                 640 


Leu Asp Tyr Ile Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu 
                645                 650                 655     


Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Glu 
            660                 665                 670         


Arg His Met Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys 
        675                 680                 685             


Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Gln Leu 
    690                 695                 700                 


Gly Ala Asp Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile 
705                 710                 715                 720 


Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln 
                725                 730                 735     


Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe 
            740                 745                 750         


Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Val 
        755                 760                 765             


Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp 
    770                 775                 780                 


Val Tyr Met Ile Met Val Lys Cys Trp Met Ser Gly Ala Asp Ser Arg 
785                 790                 795                 800 


Pro Lys Phe Arg Glu Leu Ile Ala Glu Phe Ser Lys Met Ala Arg Asp 
                805                 810                 815     


Pro Pro Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro 
            820                 825                 830         


Ser Pro Thr Asp Ser Lys Phe Tyr Arg Thr Leu Met Glu Glu Glu Asp 
        835                 840                 845             


Met Glu Asp Ile Val Asp Ala Asp Glu Tyr Leu Val Pro His Gln Gly 
    850                 855                 860                 


Phe Phe Asn Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu 
865                 870                 875                 880 


Ser Ala Thr Ser Asn Asn Ser Ala Thr Lys Cys Ile Asp Arg Asn Gly 
                885                 890                 895     


Gly His Pro Val Arg Glu Asp Gly Phe Leu Pro Ala Pro Glu Tyr Val 
            900                 905                 910         


Asn Gln Leu Met Pro Lys Lys Pro Ser Thr Ala Met Val Gln Asn Gln 
        915                 920                 925             


Ile Tyr Asn Tyr Ile Ser Leu Thr Ala Ile Ser Lys Leu Pro Met Asp 
    930                 935                 940                 


Ser Arg Tyr Gln Asn Ser His Ser Thr Ala Val Asp Asn Pro Glu Tyr 
945                 950                 955                 960 


Leu Glu 
        


<210>  11
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transcriptional repressor Tetracycline repressor (TetR)

<400>  11

Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn 
1               5                   10                  15      


Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu 
            20                  25                  30          


Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala 
        35                  40                  45              


Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His 
    50                  55                  60                  


Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn 
65                  70                  75                  80  


Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys 
                85                  90                  95      


Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu 
            100                 105                 110         


Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala 
        115                 120                 125             


Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu 
    130                 135                 140                 


Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr 
145                 150                 155                 160 


Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp 
                165                 170                 175     


His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile 
            180                 185                 190         


Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser 
        195                 200                 205 


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TetR DNA binding domain

<400>  12

Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu 
1               5                   10                  15      


Tyr Trp His Val 
            20  


<210>  13
<211>  368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tetracycline response element (TRE3GS promoter)

<400>  13
gagtttactc cctatcagtg atagagaacg tatgaagagt ttactcccta tcagtgatag       60

agaacgtatg cagactttac tccctatcag tgatagagaa cgtataagga gtttactccc      120

tatcagtgat agagaacgta tgaccagttt actccctatc agtgatagag aacgtatcta      180

cagtttactc cctatcagtg atagagaacg tatatccagt ttactcccta tcagtgatag      240

agaacgtata agctttgctt atgtaaacca gggcgcctat aaaagagtgc tgattttttg      300

agtaaacttc aattccacaa cacttttgtc ttataccaac tttccgtacc acttcctacc      360

ctcgtaaa                                                               368


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SV40 Large T-antigen nuclear localisation signal (NLS)

<400>  14

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nucleoplasmin NLS

<400>  15

Ala Val Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Leu Asp 
            20  


<210>  16
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGL-13 NLS

<400>  16

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-Myc NLS

<400>  17

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TUS-protein NLS

<400>  18

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  19
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Val Tyr Val Thr 
    50                  55                  60                  


Leu Thr Cys Ala Phe Arg Tyr Gly Gln Glu Asp Ile Asp Val Ile Gly 
65                  70                  75                  80  


Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln Val Tyr Pro 
                85                  90                  95      


Pro Val Gly Ala Ala Ser Thr Pro Thr Lys Leu Gln Glu Ser Leu Leu 
            100                 105                 110         


Lys Lys Leu Gly Ser Asn Thr Tyr Pro Phe Leu Leu Thr Phe Pro Asp 
        115                 120                 125             


Tyr Leu Pro Cys Ser Val Met Leu Gln Pro Ala Pro Gln Asp Ser Gly 
    130                 135                 140                 


Lys Ser Cys Gly Val Asp Phe Glu Val Lys Ala Phe Ala Thr Asp Ser 
145                 150                 155                 160 


Thr Asp Ala Glu Glu Asp Lys Ile Pro Lys Lys Ser Ser Val Arg Leu 
                165                 170                 175     


Leu Ile Arg Lys Val Gln His Ala Pro Leu Glu Met Gly Pro Gln Pro 
            180                 185                 190         


Arg Ala Glu Ala Ala Trp Gln Phe Phe Met Ser Asp Lys Pro Leu His 
        195                 200                 205             


Leu Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe His Gly Glu Pro Ile 
    210                 215                 220                 


Pro Val Thr Val Thr Val Thr Asn Asn Thr Glu Lys Thr Val Lys Lys 
225                 230                 235                 240 


Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val Val Leu Tyr Ser Ser 
                245                 250                 255     


Asp Tyr Tyr Val Lys Pro Val Ala Met Glu Glu Ala Gln Glu Lys Val 
            260                 265                 270         


Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu 
        275                 280                 285             


Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys 
    290                 295                 300                 


His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Lys Glu Gly Ile 
305                 310                 315                 320 


Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys 
                325                 330                 335     


Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala 
            340                 345                 350         


Thr Glu Val Pro Phe Arg Leu Met His Pro Gln Pro Glu Asp Pro Ala 
        355                 360                 365             


Lys Glu Ser Tyr Gln Asp Ala Asn Leu Val Phe Glu Glu Phe Ala Arg 
    370                 375                 380                 


His Asn Leu Lys Asp Ala Gly Glu Ala Glu Glu Gly Lys Arg Asp Lys 
385                 390                 395                 400 


Asn Asp Val Asp Glu 
                405 


<210>  20
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Asp Lys Gly Thr Arg Val Phe Lys Lys Ala Ser Pro Asn Gly 
1               5                   10                  15      


Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Ile Asp 
            20                  25                  30          


Leu Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu 
        35                  40                  45              


Lys Glu Arg Arg Val Tyr Val Thr Leu Thr Cys Ala Phe Arg Tyr Gly 
    50                  55                  60                  


Arg Glu Asp Leu Asp Val Leu Gly Leu Thr Phe Arg Lys Asp Leu Phe 
65                  70                  75                  80  


Val Ala Asn Val Gln Ser Phe Pro Pro Ala Pro Glu Asp Lys Lys Pro 
                85                  90                  95      


Leu Thr Arg Leu Gln Glu Arg Leu Ile Lys Lys Leu Gly Glu His Ala 
            100                 105                 110         


Tyr Pro Phe Thr Phe Glu Ile Pro Pro Asn Leu Pro Cys Ser Val Thr 
        115                 120                 125             


Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp Tyr 
    130                 135                 140                 


Glu Val Lys Ala Phe Cys Ala Glu Asn Leu Glu Glu Lys Ile His Lys 
145                 150                 155                 160 


Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Tyr Ala Pro Glu 
                165                 170                 175     


Arg Pro Gly Pro Gln Pro Thr Ala Glu Thr Thr Arg Gln Phe Leu Met 
            180                 185                 190         


Ser Asp Lys Pro Leu His Leu Glu Ala Ser Leu Asp Lys Glu Ile Tyr 
        195                 200                 205             


Tyr His Gly Glu Pro Ile Ser Val Asn Val His Val Thr Asn Asn Thr 
    210                 215                 220                 


Asn Lys Thr Val Lys Lys Ile Lys Ile Ser Val Arg Gln Tyr Ala Asp 
225                 230                 235                 240 


Ile Cys Leu Phe Asn Thr Ala Gln Tyr Lys Cys Pro Val Ala Met Glu 
                245                 250                 255     


Glu Ala Asp Asp Thr Val Ala Pro Ser Ser Thr Phe Cys Lys Val Tyr 
            260                 265                 270         


Thr Leu Thr Pro Phe Leu Ala Asn Asn Arg Glu Lys Arg Gly Leu Ala 
        275                 280                 285             


Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr 
    290                 295                 300                 


Leu Leu Arg Glu Gly Ala Asn Arg Glu Ile Leu Gly Ile Ile Val Ser 
305                 310                 315                 320 


Tyr Lys Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Leu Leu Gly 
                325                 330                 335     


Asp Leu Ala Ser Ser Asp Val Ala Val Glu Leu Pro Phe Thr Leu Met 
            340                 345                 350         


His Pro Lys Pro Lys Glu Glu Pro Pro His Arg Glu Val Pro Glu Asn 
        355                 360                 365             


Glu Thr Pro Val Asp Thr Asn Leu Ile Glu Leu Asp Thr Asn Asp Asp 
    370                 375                 380                 


Asp Ile Val Phe Glu Asp Phe Ala Arg Gln Arg Leu Lys Gly Met Lys 
385                 390                 395                 400 


Asp Asp Lys Glu Glu Glu Glu Asp Gly Thr Gly Ser Pro Gln Leu Asn 
                405                 410                 415     


Asn Arg 
        


<210>  21
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Glu Lys Pro Gly Thr Arg Val Phe Lys Lys Ser Ser Pro Asn 
1               5                   10                  15      


Cys Lys Leu Thr Val Tyr Leu Gly Lys Arg Asp Phe Val Asp His Leu 
            20                  25                  30          


Asp Lys Val Asp Pro Val Asp Gly Val Val Leu Val Asp Pro Asp Tyr 
        35                  40                  45              


Leu Lys Asp Arg Lys Val Phe Val Thr Leu Thr Cys Ala Phe Arg Tyr 
    50                  55                  60                  


Gly Arg Glu Asp Leu Asp Val Leu Gly Leu Ser Phe Arg Lys Asp Leu 
65                  70                  75                  80  


Phe Ile Ala Thr Tyr Gln Ala Phe Pro Pro Val Pro Asn Pro Pro Arg 
                85                  90                  95      


Pro Pro Thr Arg Leu Gln Asp Arg Leu Leu Arg Lys Leu Gly Gln His 
            100                 105                 110         


Ala His Pro Phe Phe Phe Thr Ile Pro Gln Asn Leu Pro Cys Ser Val 
        115                 120                 125             


Thr Leu Gln Pro Gly Pro Glu Asp Thr Gly Lys Ala Cys Gly Val Asp 
    130                 135                 140                 


Phe Glu Ile Arg Ala Phe Cys Ala Lys Ser Leu Glu Glu Lys Ser His 
145                 150                 155                 160 


Lys Arg Asn Ser Val Arg Leu Val Ile Arg Lys Val Gln Phe Ala Pro 
                165                 170                 175     


Glu Lys Pro Gly Pro Gln Pro Ser Ala Glu Thr Thr Arg His Phe Leu 
            180                 185                 190         


Met Ser Asp Arg Ser Leu His Leu Glu Ala Ser Leu Asp Lys Glu Leu 
        195                 200                 205             


Tyr Tyr His Gly Glu Pro Leu Asn Val Asn Val His Val Thr Asn Asn 
    210                 215                 220                 


Ser Thr Lys Thr Val Lys Lys Ile Lys Val Ser Val Arg Gln Tyr Ala 
225                 230                 235                 240 


Asp Ile Cys Leu Phe Ser Thr Ala Gln Tyr Lys Cys Pro Val Ala Gln 
                245                 250                 255     


Leu Glu Gln Asp Asp Gln Val Ser Pro Ser Ser Thr Phe Cys Lys Val 
            260                 265                 270         


Tyr Thr Ile Thr Pro Leu Leu Ser Asp Asn Arg Glu Lys Arg Gly Leu 
        275                 280                 285             


Ala Leu Asp Gly Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser 
    290                 295                 300                 


Thr Ile Val Lys Glu Gly Ala Asn Lys Glu Val Leu Gly Ile Leu Val 
305                 310                 315                 320 


Ser Tyr Arg Val Lys Val Lys Leu Val Val Ser Arg Gly Gly Asp Val 
                325                 330                 335     


Ser Val Glu Leu Pro Phe Val Leu Met His Pro Lys Pro His Asp His 
            340                 345                 350         


Ile Pro Leu Pro Arg Pro Gln Ser Ala Ala Pro Glu Thr Asp Val Pro 
        355                 360                 365             


Val Asp Thr Asn Leu Ile Glu Phe Asp Thr Asn Tyr Ala Thr Asp Asp 
    370                 375                 380                 


Asp Ile Val Phe Glu Asp Phe Ala Arg Leu Arg Leu Lys Gly Met Lys 
385                 390                 395                 400 


Asp Asp Asp Tyr Asp Asp Gln Leu Cys 
                405                 


<210>  22
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Lys Val Phe Lys Lys Thr Ser Ser Asn Gly Lys Leu Ser Ile 
1               5                   10                  15      


Tyr Leu Gly Lys Arg Asp Phe Val Asp His Val Asp Thr Val Glu Pro 
            20                  25                  30          


Ile Asp Gly Val Val Leu Val Asp Pro Glu Tyr Leu Lys Cys Arg Lys 
        35                  40                  45              


Leu Phe Val Met Leu Thr Cys Ala Phe Arg Tyr Gly Arg Asp Asp Leu 
    50                  55                  60                  


Glu Val Ile Gly Leu Thr Phe Arg Lys Asp Leu Tyr Val Gln Thr Leu 
65                  70                  75                  80  


Gln Val Val Pro Ala Glu Ser Ser Ser Pro Gln Gly Pro Leu Thr Val 
                85                  90                  95      


Leu Gln Glu Arg Leu Leu His Lys Leu Gly Asp Asn Ala Tyr Pro Phe 
            100                 105                 110         


Thr Leu Gln Met Val Thr Asn Leu Pro Cys Ser Val Thr Leu Gln Pro 
        115                 120                 125             


Gly Pro Glu Asp Ala Gly Lys Pro Cys Gly Ile Asp Phe Glu Val Lys 
    130                 135                 140                 


Ser Phe Cys Ala Glu Asn Pro Glu Glu Thr Val Ser Lys Arg Asp Tyr 
145                 150                 155                 160 


Val Arg Leu Val Val Arg Lys Val Gln Phe Ala Pro Pro Glu Ala Gly 
                165                 170                 175     


Pro Gly Pro Ser Ala Gln Thr Ile Arg Arg Phe Leu Leu Ser Ala Gln 
            180                 185                 190         


Pro Leu Gln Leu Gln Ala Trp Met Asp Arg Glu Val His Tyr His Gly 
        195                 200                 205             


Glu Pro Ile Ser Val Asn Val Ser Ile Asn Asn Cys Thr Asn Lys Val 
    210                 215                 220                 


Ile Lys Lys Ile Lys Ile Ser Val Asp Gln Ile Thr Asp Val Val Leu 
225                 230                 235                 240 


Tyr Ser Leu Asp Lys Tyr Thr Lys Thr Val Phe Ile Gln Glu Phe Thr 
                245                 250                 255     


Glu Thr Val Ala Ala Asn Ser Ser Phe Ser Gln Ser Phe Ala Val Thr 
            260                 265                 270         


Pro Ile Leu Ala Ala Ser Cys Gln Lys Arg Gly Leu Ala Leu Asp Gly 
        275                 280                 285             


Lys Leu Lys His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Arg 
    290                 295                 300                 


Pro Gly Met Asp Lys Glu Leu Leu Gly Ile Leu Val Ser Tyr Lys Val 
305                 310                 315                 320 


Arg Val Asn Leu Met Val Ser Cys Gly Gly Ile Leu Gly Asp Leu Thr 
                325                 330                 335     


Ala Ser Asp Val Gly Val Glu Leu Pro Leu Val Leu Ile His Pro Lys 
            340                 345                 350         


Pro Ser His Glu Ala Ala Ser Ser Glu Asp Ile Val Ile Glu Glu Phe 
        355                 360                 365             


Thr Arg Lys Gly Glu Glu Glu Ser Gln Lys Ala Val Glu Ala Glu Gly 
    370                 375                 380                 


Asp Glu Gly Ser 
385             


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Tobacco Etch Virus (TEV) cleavage site

<400>  23

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  24
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TEV protease

<400>  24

Ser Leu Phe Lys Gly Pro Arg Asp Tyr Asn Pro Ile Ser Ser Thr Ile 
1               5                   10                  15      


Cys His Leu Thr Asn Glu Ser Asp Gly His Thr Thr Ser Leu Tyr Gly 
            20                  25                  30          


Ile Gly Phe Gly Pro Phe Ile Ile Thr Asn Lys His Leu Phe Arg Arg 
        35                  40                  45              


Asn Asn Gly Thr Leu Leu Val Gln Ser Leu His Gly Val Phe Lys Val 
    50                  55                  60                  


Lys Asn Thr Thr Thr Leu Gln Gln His Leu Ile Asp Gly Arg Asp Met 
65                  70                  75                  80  


Ile Ile Ile Arg Met Pro Lys Asp Phe Pro Pro Phe Pro Gln Lys Leu 
                85                  90                  95      


Lys Phe Arg Glu Pro Gln Arg Glu Glu Arg Ile Cys Leu Val Thr Thr 
            100                 105                 110         


Asn Phe Gln Thr Lys Ser Met Ser Ser Met Val Ser Asp Thr Ser Cys 
        115                 120                 125             


Thr Phe Pro Ser Ser Asp Gly Ile Phe Trp Lys His Trp Ile Gln Thr 
    130                 135                 140                 


Lys Asp Gly Gln Cys Gly Ser Pro Leu Val Ser Thr Arg Asp Gly Phe 
145                 150                 155                 160 


Ile Val Gly Ile His Ser Ala Ser Asn Phe Thr Asn Thr Asn Asn Tyr 
                165                 170                 175     


Phe Thr Ser Val Pro Lys Asn Phe Met Glu Leu Leu Thr Asn Gln Glu 
            180                 185                 190         


Ala Gln Gln Trp Val Ser Gly Trp Arg Leu Asn Ala Asp Ser Val Leu 
        195                 200                 205             


Trp Gly Gly His Lys Val Phe Met Ser Lys Pro Glu Glu Pro Phe Gln 
    210                 215                 220                 


Pro Val Lys Glu Ala Thr Gln Leu Met Asn Glu Leu Val Tyr Ser Gln 
225                 230                 235                 240 


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  basic amino acid furin target sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Arg or Lys

<400>  25

Arg Xaa Xaa Arg 
1               


<210>  26
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tobacco vein mottling virus (TVMV) cleavage site

<400>  27

Glu Thr Val Arg Phe Gln Gly Ser 
1               5               


<210>  28
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TVMV protease

<400>  28

Ser Lys Ala Leu Leu Lys Gly Val Arg Asp Phe Asn Pro Ile Ser Ala 
1               5                   10                  15      


Cys Val Trp Leu Leu Glu Asn Ser Ser Asp Gly His Ser Glu Arg Leu 
            20                  25                  30          


Phe Gly Ile Gly Phe Gly Pro Tyr Ile Ile Ala Asn Gln His Leu Phe 
        35                  40                  45              


Arg Arg Asn Asn Gly Glu Leu Thr Ile Lys Thr Met His Gly Glu Phe 
    50                  55                  60                  


Lys Val Lys Asn Ser Thr Gln Leu Gln Met Lys Pro Val Glu Gly Arg 
65                  70                  75                  80  


Asp Ile Ile Val Ile Lys Met Ala Lys Asp Phe Pro Pro Phe Pro Gln 
                85                  90                  95      


Lys Leu Lys Phe Arg Gln Pro Thr Ile Lys Asp Arg Val Cys Met Val 
            100                 105                 110         


Ser Thr Asn Phe Gln Gln Lys Ser Val Ser Ser Leu Val Ser Glu Ser 
        115                 120                 125             


Ser His Ile Val His Lys Glu Asp Thr Ser Phe Trp Gln His Trp Ile 
    130                 135                 140                 


Thr Thr Lys Asp Gly Gln Cys Gly Ser Pro Leu Val Ser Ile Ile Asp 
145                 150                 155                 160 


Gly Asn Ile Leu Gly Ile His Ser Leu Thr His Thr Thr Asn Gly Ser 
                165                 170                 175     


Asn Tyr Phe Val Glu Phe Pro Glu Lys Phe Val Ala Thr Tyr Leu Asp 
            180                 185                 190         


Ala Ala Asp Gly Trp Cys Lys Asn Trp Lys Phe Asn Ala Asp Lys Ile 
        195                 200                 205             


Ser Trp Gly Ser Phe Thr Leu Val Glu Asp Ala Pro Glu Asp Asp Phe 
    210                 215                 220                 


Met Ala Lys Lys Thr Val Ala Ala Ile Met Asp Asp Leu Val Arg Thr 
225                 230                 235                 240 


Gln 
    


<210>  29
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plum pox virus Nia protease

<400>  29

Gln Phe Trp Asp Gly Phe Thr Asn Ser Phe Met Gln Cys Lys Leu Arg 
1               5                   10                  15      


Glu Thr Asp His Gln Cys Thr Ser Asp Leu Asp Val Lys Glu Cys Gly 
            20                  25                  30          


Tyr Val Ala Ala Ile Val Cys Gln Ala Ile Ile Pro Cys Gly Lys Ile 
        35                  40                  45              


Thr Cys Leu Gln Cys Ala Gln Lys Tyr Ser Tyr Met Ser Gln Gln Glu 
    50                  55                  60                  


Ile Arg Asp Arg Phe Ser Thr Val Ile Glu Gln His Glu Lys Thr Val 
65                  70                  75                  80  


Met Asp Asn Tyr Pro Gln Phe Ser His Val Leu Ala Phe Leu Lys Arg 
                85                  90                  95      


Tyr Arg Glu Leu Met Arg Val Glu Asn Gln Asn Tyr Glu Ala Leu Lys 
            100                 105                 110         


Asp Ile Thr His Met Ile Gly Glu Arg Lys Glu Ala Pro Phe Ser His 
        115                 120                 125             


Leu Asn Lys Ile Asn Glu Leu Ile Ile Lys Gly Gly Met Met Ser Ala 
    130                 135                 140                 


Gln Asp Tyr Met Glu Ala Ser Asn Cys Leu Arg Glu Leu Ala Arg Tyr 
145                 150                 155                 160 


Gln Lys Asn Arg Thr Glu Asn Ile Gln Ser Gly Ser Ile Lys Ala Phe 
                165                 170                 175     


Arg Asn Lys Ile Ser Ala Lys Ala Tyr Val Asn Met Gln Leu Met Cys 
            180                 185                 190         


Asp Asn Gln Leu Asp Thr Asn Gly Asn Phe Val Trp Gly Gln Arg Glu 
        195                 200                 205             


Tyr His Ala Lys Arg Phe Phe Arg Asn Tyr Phe Asp Val Ile Asp Thr 
    210                 215                 220                 


Ser Glu Gly Tyr Arg Arg His Ile Val Arg Glu Asn Pro Arg Gly Thr 
225                 230                 235                 240 


Arg Lys Leu Ala Ile Gly Asn Leu Val Met Ser Thr Asn Leu Ala Ala 
                245                 250                 255     


Leu Arg Arg Gln Leu Leu Gly Glu Glu Cys Thr Asn Phe Asp Val Ser 
            260                 265                 270         


Lys Glu Cys Thr Ser Lys Arg Gly Glu Asn Phe Val Tyr Gln Cys Cys 
        275                 280                 285             


Cys Val Thr His Glu Asp Gly Thr Pro Leu Lys Ser Glu Ile Ile Ser 
    290                 295                 300                 


Pro Thr Lys Asn His Leu Val Ile Gly Asn Ser Gly Asp Ser Lys Tyr 
305                 310                 315                 320 


Val Asp Leu Pro Lys Thr Asp Lys Gly Gly Met Tyr Ile Ala Lys Ala 
                325                 330                 335     


Gly Tyr Cys Tyr Ile Asn Val Phe Leu Ala Met Leu Val Asn Val Asn 
            340                 345                 350         


Glu Ser Glu Ala Lys Ser Phe Thr Lys Thr Val Arg Asp Thr Leu Val 
        355                 360                 365             


Pro Lys Leu Gly Leu Trp Pro Ser Met Met Asp Leu Ala Thr Ala Cys 
    370                 375                 380                 


His Phe Leu Ala Val Leu Tyr Pro Glu Thr Arg Asn Ala Glu Leu Pro 
385                 390                 395                 400 


Arg Ile Leu Val Asp His Glu Ser Lys Leu Phe His Val Val Asp Ser 
                405                 410                 415     


Tyr Gly Ser Leu Ser Thr Gly Leu His Ile Leu Lys Ala Asn Thr Val 
            420                 425                 430         


Asn Gln Leu Ile Ser Phe Ala Ser Asp Thr Leu Asp Ser Ser Met Lys 
        435                 440                 445             


Met Tyr Leu Val Gly 
    450             


<210>  30
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  30

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Gly 
            20      


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  31

Met Ser Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  32

Met Ala Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  33
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, hinge-CH2CH3 of human IgG1

<400>  33

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230                 


<210>  34
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, human CD8 stalk

<400>  34

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, human IgG1 hinge

<400>  35

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210>  36
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer sequence, CD2 ectodomain

<400>  36

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp 
            180                 185 


<210>  37
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD34 ectodomain

<400>  37

Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly 
1               5                   10                  15      


Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr 
            20                  25                  30          


Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly 
        35                  40                  45              


Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser 
    50                  55                  60                  


Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln 
65                  70                  75                  80  


Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val 
                85                  90                  95      


Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val 
            100                 105                 110         


Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys 
        115                 120                 125             


Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile 
    130                 135                 140                 


Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu 
145                 150                 155                 160 


Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly 
                165                 170                 175     


Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp 
            180                 185                 190         


Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg 
        195                 200                 205             


Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser 
    210                 215                 220                 


Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly 
225                 230                 235                 240 


Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser 
                245                 250                 255     


Gln Lys Thr 
            


<210>  38
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  38

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  39
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 Z endodomain

<400>  39

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  40
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 endodomain

<400>  40

Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
1               5                   10                  15      


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            20                  25                  30          


Asp Phe Ala Ala Tyr 
        35          


<210>  41
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 endodomain

<400>  41

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  42
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB endodomain

<400>  42

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  43
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 and CD3 Zeta endodomains

<400>  43

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
        35                  40                  45              


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
65                  70                  75                  80  


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            100                 105                 110         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        115                 120                 125             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    130                 135                 140                 


His Met Gln Ala Leu Pro Pro Arg 
145                 150         


<210>  44
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28, OX40 and CD3 Zeta endodomains

<400>  44

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp 
        35                  40                  45              


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
    50                  55                  60                  


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
65                  70                  75                  80  


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                85                  90                  95      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            100                 105                 110         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        115                 120                 125             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    130                 135                 140                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
145                 150                 155                 160 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                165                 170                 175     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185             


<210>  45
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB, OX40 and CD3 Zeta endodomains

<400>  45

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Arg Asp Gln Arg Leu 
        35                  40                  45              


Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
    50                  55                  60                  


Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg 
65                  70                  75                  80  


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                85                  90                  95      


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            100                 105                 110         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        115                 120                 125             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    130                 135                 140                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
145                 150                 155                 160 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                165                 170                 175     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185                 190     


<210>  46
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  46

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  47
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  47

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  48
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  48

Tyr His Ala Asp Tyr Tyr Lys Gln Arg Leu Ile His Asp Val Glu Met 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  49

His Tyr Ala Gly Tyr Phe Ala Asp Leu Leu Ile His Asp Ile Glu Thr 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  50
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  50

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  51
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  51

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  52
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  52

Ala Ala Arg Gln Met Leu Leu Leu Leu Ser Gly Asp Val Glu Thr Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  53

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  54
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  54

Thr Arg Ala Glu Ile Glu Asp Glu Leu Ile Arg Ala Gly Ile Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  55
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  55

Thr Arg Ala Glu Ile Glu Asp Glu Leu Ile Arg Ala Asp Ile Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  56
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  56

Ala Lys Phe Gln Ile Asp Lys Ile Leu Ile Ser Gly Asp Val Glu Leu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  57
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  57

Ser Ser Ile Ile Arg Thr Lys Met Leu Val Ser Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  58
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  58

Cys Asp Ala Gln Arg Gln Lys Leu Leu Leu Ser Gly Asp Ile Glu Gln 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site, 2A-like sequence

<400>  59

Tyr Pro Ile Asp Phe Gly Gly Phe Leu Val Lys Ala Asp Ser Glu Phe 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  60
<211>  8736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  illustrative construct nucleic acid sequence

<400>  60
ggcctgaaat aacctctgaa agaggaactt ggttaggtac cttctgaggc ggaaagaacc       60

agctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa      120

gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc ccaggctccc      180

cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccttaag      240

aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca      300

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      360

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      420

gccgcattgc agagatattg tatttaagtg cctagctcga tacaataaac gcgccagtcc      480

tccgattgac tgcgtcgccc gggtacccgt attcccaata aagcctcttg ctgtttgcat      540

ccgaatcgtg gactcgctga tccttgggag ggtctcctca gattgattga ctgcccacct      600

cgggggtctt tcatttggag gttccaccga gatttggaga cccctgccca gggaccaccg      660

acccccccgc cgggaggtaa gctggccagc ggtcgtttcg tgtctgtctc tgtctttggg      720

cgtgtttgtg ccggcatcta gtgtttgcgc ctgcgtctgt actagttggc taactagatc      780

tgtatctggc ggtcccgcgg aagaactgac gagttcgtat tcccggccgc agcccctggg      840

agacgtccca gcggcctcgg gggcccgttt tgtggcccat tctgtatcag ttaacctacc      900

cgagtcggac tttttggagc tccgccactg tccgaggggt acgtggcttt gttgggggac      960

gagagacaga gacacttccc gcccccgtct gaatttttgc tttcggtttt acgccgaaac     1020

cgcgccgcgc gtcttgtctg ctgcagcatc gttctgtgtt gtctctgtct gactgtgttt     1080

ctgtatttgt ctgaaaatta gcggccgatc tgacgcgact cgagtttact ccctatcagt     1140

gatagagaac gtatgaagag tttactccct atcagtgata gagaacgtat gcagacttta     1200

ctccctatca gtgatagaga acgtataagg agtttactcc ctatcagtga tagagaacgt     1260

atgaccagtt tactccctat cagtgataga gaacgtatct acagtttact ccctatcagt     1320

gatagagaac gtatatccag tttactccct atcagtgata gagaacgtat aagctttgct     1380

tatgtaaacc agggcgccta taaaagagtg ctgatttttt gagtaaactt caattccaca     1440

acacttttgt cttataccaa ctttccgtac cacttcctac cctcgtaaag tcgacaccat     1500

ggagaccgac accctgctgc tgtgggtgct gctgctgtgg gtgccaggca gcaccggcga     1560

ggtgcagctg cagcagagcg gacccgagct gatcaagcca ggcgccagcg tgaagatgag     1620

ctgcaaggcc agcggctaca ccttcaccag ctacgtgatg cactgggtga agcagaagcc     1680

aggccagggc ctggagtgga tcggctacat caacccctac aacgacggca ccaagtacaa     1740

cgagaagttc aagggcaagg ccaccctgac cagcgacaag agcagcagca ccgcctacat     1800

ggagctgagc agcctgacca gcgaggacag cgccgtgtac tactgcgcca gaggcaccta     1860

ctactacggc agccgggtgt tcgactactg gggccagggc accaccctga ccgtgagctc     1920

tggcggaggc ggctctggcg gaggcggctc tggcggaggc ggcagcgaca tcgtgatgac     1980

ccaggctgcc cccagcatcc ccgtgacccc aggcgagagc gtgagcatca gctgccggag     2040

cagcaagagc ctgctgaaca gcaacggcaa cacctacctg tactggttcc tgcagcggcc     2100

aggccagagc ccccagctgc tgatctaccg gatgagcaac ctggccagcg gcgtgcccga     2160

ccggttcagc ggcagcggca gcggcaccgc cttcaccctg cggatcagcc gggtggaggc     2220

cgaggacgtg ggcgtgtact actgcatgca gcacctggag taccccttca ccttcggagc     2280

cggcaccaag ctggagctga agcggtcgga tcccaccacc accccagccc cacggccacc     2340

tacccctgcc ccaaccatcg ccagccagcc cctgagcctg cggcctgaag cctgcaggcc     2400

tgccgccgga ggagccgtgc acacaagggg cctggacttc gcctgcgaca tctatatctg     2460

ggcccccctg gccgggacat gcggggtgct gctgctgtcc ctggtgatta cactgtattg     2520

caaacggggc cggaagaagc tgctgtacat cttcaagcag cccttcatgc ggcccgtgca     2580

gaccacccag gaggaggacg gctgcagctg ccggttcccc gaggaagagg aaggcggctg     2640

cgagctgcgg gtgaagttca gccggagcgc cgacgcccca gcctaccagc agggccagaa     2700

ccagctgtac aacgagctga acctgggacg gcgggaggag tacgacgtgc tggacaagcg     2760

gcggggacgg gaccccgaga tgggcggcaa gcctcgccgg aagaatcccc aggagggcct     2820

gtacaacgag ctgcagaagg acaagatggc cgaggcctac agcgagatcg gcatgaaggg     2880

cgagcggcgc cggggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa     2940

ggacacctac gacgccctgc acatgcaggc cctgccaccc cggtgaacgc gtgccgctcc     3000

ggattagtcc aatttgttaa agacaggatt cgaggagctt gataattcca cggggttggg     3060

gttgcgcctt ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg     3120

ttccgggaaa cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag     3180

cgtcacccgg atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc     3240

cctaagtcgg gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc     3300

acgtctcact agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc     3360

gcgatgggct gtggccaata gcggctgctc agcagggcgc gccgagagca gcggccggga     3420

aggggcggtg cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg     3480

gtgttccgca ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg     3540

aatcaccgac ctctctcccc agggggatca tcgaattcgc caacatgcgg ccgcgccacc     3600

atgaagacga tcatcgccct gagctacatc ttctgcctgg tattcgccga ctacaaggac     3660

gatgatgacg ccagcatcga tatgtataat ggctcctgtt gccggattga aggcgacact     3720

atctctcaag taatgccccc cctcctgata gtggccttcg tcctgggcgc tcttggtaat     3780

ggggttgcac tctgtggttt ctgtttccac atgaaaacct ggaagccctc aacagtgtac     3840

ctctttaacc ttgccgtggc agacttcctg cttatgattt gcctgccctt taggaccgac     3900

tattatctgc gacgccgcca ttgggctttc ggcgacatcc cctgtcgggt tggtctgttt     3960

actctggcta tgaatcgggc cggcagtatc gtctttctca ctgtggtcgc tgccgacaga     4020

tacttcaagg tagtgcaccc ccaccacgca gtgaacacaa tctccactag agttgcagct     4080

ggaattgtgt gcaccctgtg ggctctggta atcctgggca cagtatacct gctcctggag     4140

aatcatttgt gcgtgcagga gactgctgtg tcatgtgaat cttttattat ggagtccgca     4200

aacgggtggc atgatatcat gtttcaactg gagttcttta tgccccttgg catcattctg     4260

ttttgctcat tcaagatcgt ttggtctctc cggcgccggc agcagctggc ccggcaagct     4320

cggatgaaaa aggccacgcg ctttatcatg gttgtggcta tcgtcttcat cacctgctac     4380

cttccttccg tgtccgcaag actgtatttt ctgtggaccg tccccagcag cgcttgcgat     4440

cccagtgtcc acggcgccct ccacatcacc ttgagcttta cgtacatgaa ctctatgctg     4500

gaccccctgg tgtactattt tagctctccc tccttcccga aattctataa taaacttaag     4560

atctgcagcc tcaaaccaaa gcaaccaggc cattccaaga ctcagcgccc tgaagagatg     4620

cccattagca accttggtag acggagctgc atctccgtcg cgaactcatt tcagtctcag     4680

tccgacggac agtgggaccc acacattgtt gagtggcaca tcgataccgg tggacgcacc     4740

ccacccagcc tgggtcccca agatgagtcc tgcaccaccg ccagctcctc cctggccaag     4800

gacacttcat cgaccggtga gaacctgtac ttccagctaa gattagataa aagtaaagtg     4860

attaacagcg cattagagct gcttaatgag gtcggaatcg aaggtttaac aacccgtaaa     4920

ctcgcccaga agctaggtgt agagcagcct acattgtatt ggcatgtaaa aaataagcgg     4980

gctttgctcg acgccttagc cattgagatg ttagataggc accatactca cttttgccct     5040

ttagaagggg aaagctggca agatttttta cgtaataacg ctaaaagttt tagatgtgct     5100

ttactaagtc atcgcgatgg agcaaaagta catttaggta cacggcctac agaaaaacag     5160

tatgaaactc tcgaaaatca attagccttt ttatgccaac aaggtttttc actagagaat     5220

gcattatatg cactcagcgc tgtggggcat tttactttag gttgcgtatt ggaagatcaa     5280

gagcatcaag tcgctaaaga agaaagggaa acacctacta ctgatagtat gccgccatta     5340

ttacgacaag ctatcgaatt atttgatcac caaggtgcag agccagcctt cttattcggc     5400

cttgaattga tcatatgcgg attagaaaaa caacttaaat gtgaaagtgg gtccgcgtac     5460

agccgcgcgc gtacgaaaaa caattacggg tctaccatcg agggcctgct cgatctcccg     5520

gacgacgacg cccccgaaga ggcggggctg gcggctccgc gcctgtcctt tctccccgcg     5580

ggacacacgc gcagactgtc gacggccccc ccgaccgatg tcagcctggg ggacgagctc     5640

cacttagacg gcgaggacgt ggcgatggcg catgccgacg cgctagacga tttcgatctg     5700

gacatgttgg gggacgggga ttccccgggt ccgggattta ccccccacga ctccgccccc     5760

tacggcgctc tggatatggc cgacttcgag tttgagcaga tgtttaccga tgcccttgga     5820

attgacgagt acggtgggca gtgtactaat tatgctctct tgaaattggc tggagatgtc     5880

gagtccaacc ctgggccaat gggtgaaaag ccaggtacca gggtcttcaa gaagtcgagc     5940

cctaactgca agctcaccgt gtacttgggc aagcgggact tcgtagatca cctggacaaa     6000

gtggaccctg tagatggcgt ggtgcttgtg gaccctgact acctgaagga ccgcaaagtg     6060

tttgtgaccc tcacctgcgc cttccgctat ggccgtgaag acctggatgt gctgggcttg     6120

tccttccgca aagacctgtt catcgccacc taccaggcct tccccccggt gcccaaccca     6180

ccccggcccc ccacccgcct gcaggaccgg ctgctgagga agctgggcca gcatgcccac     6240

cccttcttct tcaccatacc ccagaatctt ccatgctccg tcacactgca gccaggccca     6300

gaggatacag gaaaggcctg cggcgtagac tttgagattc gagccttctg tgctaaatca     6360

ctagaagaga aaagccacaa aaggaactct gtgcggctgg tgatccgaaa ggtgcagttc     6420

gccccggaga aacccggccc ccagccttca gccgaaacca cacgccactt cctcatgtct     6480

gaccgctccc tgcacctcga ggcttccctg gacaaggagc tgtactacca cggggagccc     6540

ctcaatgtaa atgtccacgt caccaacaac tccaccaaga ccgtcaagaa gatcaaagtc     6600

tctgtgagac agtacgccga catctgcctc ttcagcaccg cccagtacaa gtgtcctgtg     6660

gctcaactcg aacaagatga ccaggtatct cccagctcca cattctgtaa ggtgtacacc     6720

ataaccccac tgctcagtga caaccgggag aagcggggtc tcgccctgga tgggaaactc     6780

aagcacgagg acaccaacct ggcttccagc accatcgtga aggagggtgc caacaaggag     6840

gtgctgggaa tcctggtgtc ctacagggtc aaggtgaagc tggtggtgtc tcgaggcggg     6900

gatgtctctg tggagctgcc ttttgttctt atgcacccca agccccacga ccacatcccc     6960

ctccccagac cccagtcagc cgctccggag acagatgtcc ctgtggacac caacctcatt     7020

gaatttgata ccaactatgc cacagatgat gacattgtgt ttgaggactt tgcccggctt     7080

cggctgaagg ggatgaagga tgacgactat gatgatcaac tctgcagctt gtttaaggga     7140

ccacgtgatt acaacccgat atcgagcacc atttgtcatt tgacgaatga atctgatggg     7200

cacacaacat cgttgtatgg tattggattt ggtcccttca tcattacaaa caagcacttg     7260

tttagaagaa ataatggaac actgttggtc caatcactac atggtgtatt caaggtcaag     7320

aacaccacga ctttgcaaca acacctcatt gatgggaggg acatgataat tattcgcatg     7380

cctaaggatt tcccaccatt tcctcaaaag ctgaaattta gagagccaca aagggaagag     7440

cgcatatgtc ttgtgacaac caacttccaa actaagagca tgtctagcat ggtgtcagac     7500

actagttgca cattcccttc atctgatggc atattctgga agcattggat tcaaaccaag     7560

gatgggcagt gtggcagtcc attagtatca actagagatg ggttcattgt tggtatacac     7620

tcagcatcga atttcaccaa cacaaacaat tatttcacaa gcgtgccgaa aaacttcatg     7680

gaattgttga caaatcagga ggcgcagcag tgggttagtg gttggcgatt aaatgctgac     7740

tcagtattgt gggggggcca taaagttttc atgagcaaac ctgaagagcc ttttcagcca     7800

gttaaggaag cgactcaact catgaatgaa ttggtgtact cgcaatgagg atcccccggg     7860

ctgcaggaat tcgagcatct taccgccatt tatacccata tttgttctgt ttttcttgat     7920

ttgggtatac atttaaatgt taataaaaca aaatggtggg gcaatcattt acatttttag     7980

ggatatgtaa ttactagttc aggtgtattg ccacaagaca aacatgttaa gaaactttcc     8040

cgttatttac gctctgttcc tgttaatcaa cctctggatt acaaaatttg tgaaagattg     8100

actgatattc ttaactatgt tgctcctttt acgctgtgtg gatatgctgc tttaatgcct     8160

ctgtatcatg ctattgcttc ccgtacggct ttcgttttct cctccttgta taaatcctgg     8220

ttgctgtctc tttatgagga gttgtggccc gttgtccgtc aacgtggcgt ggtgtgctct     8280

gtgtttgctg acgcaacccc cactggctgg ggcattgcca ccacctgtca actcctttct     8340

gggactttcg ctttccccct cccgatcgcc acggcagaac tcatcgccgc ctgccttgcc     8400

cgctgctgga caggggctag gttgctgggc actgataatt ccgtggtgtt gtcggggaag     8460

ctgacgtcct ttcgaattcg atatcaagct taacacgagc catagataga ataaaagatt     8520

ttatttagtc tccagaaaaa ggggggaatg aaagacccca ccgctagcga tatcgaattc     8580

acaacccctc actcggcgcg ccagtcctcc gacagactga gtcgcccggg tacccgtgtt     8640

ctcaataaac cctcttgcag ttgcatccga ctcgtggtct cgctgttcct tgggagggtc     8700

tcctctgagt gattgactgc ccacctcggg ggtctt                               8736


<210>  61
<211>  11238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  illustrative construct nucleic acid sequence

<400>  61
ggcctgaaat aacctctgaa agaggaactt ggttaggtac cttctgaggc ggaaagaacc       60

agctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa      120

gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc ccaggctccc      180

cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccttaag      240

aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca      300

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      360

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      420

gccgcattgc agagatattg tatttaagtg cctagctcga tacaataaac gcgccagtcc      480

tccgattgac tgcgtcgccc gggtacccgt attcccaata aagcctcttg ctgtttgcat      540

ccgaatcgtg gactcgctga tccttgggag ggtctcctca gattgattga ctgcccacct      600

cgggggtctt tcatttggag gttccaccga gatttggaga cccctgccca gggaccaccg      660

acccccccgc cgggaggtaa gctggccagc ggtcgtttcg tgtctgtctc tgtctttggg      720

cgtgtttgtg ccggcatcta gtgtttgcgc ctgcgtctgt actagttggc taactagatc      780

tgtatctggc ggtcccgcgg aagaactgac gagttcgtat tcccggccgc agcccctggg      840

agacgtccca gcggcctcgg gggcccgttt tgtggcccat tctgtatcag ttaacctacc      900

cgagtcggac tttttggagc tccgccactg tccgaggggt acgtggcttt gttgggggac      960

gagagacaga gacacttccc gcccccgtct gaatttttgc tttcggtttt acgccgaaac     1020

cgcgccgcgc gtcttgtctg ctgcagcatc gttctgtgtt gtctctgtct gactgtgttt     1080

ctgtatttgt ctgaaaatta gcggccgatc tgacgcgact cgagtttact ccctatcagt     1140

gatagagaac gtatgaagag tttactccct atcagtgata gagaacgtat gcagacttta     1200

ctccctatca gtgatagaga acgtataagg agtttactcc ctatcagtga tagagaacgt     1260

atgaccagtt tactccctat cagtgataga gaacgtatct acagtttact ccctatcagt     1320

gatagagaac gtatatccag tttactccct atcagtgata gagaacgtat aagctttgct     1380

tatgtaaacc agggcgccta taaaagagtg ctgatttttt gagtaaactt caattccaca     1440

acacttttgt cttataccaa ctttccgtac cacttcctac cctcgtaaag tcgacaccat     1500

ggagaccgac accctgctgc tgtgggtgct gctgctgtgg gtgccaggca gcaccggcga     1560

ggtgcagctg cagcagagcg gacccgagct gatcaagcca ggcgccagcg tgaagatgag     1620

ctgcaaggcc agcggctaca ccttcaccag ctacgtgatg cactgggtga agcagaagcc     1680

aggccagggc ctggagtgga tcggctacat caacccctac aacgacggca ccaagtacaa     1740

cgagaagttc aagggcaagg ccaccctgac cagcgacaag agcagcagca ccgcctacat     1800

ggagctgagc agcctgacca gcgaggacag cgccgtgtac tactgcgcca gaggcaccta     1860

ctactacggc agccgggtgt tcgactactg gggccagggc accaccctga ccgtgagctc     1920

tggcggaggc ggctctggcg gaggcggctc tggcggaggc ggcagcgaca tcgtgatgac     1980

ccaggctgcc cccagcatcc ccgtgacccc aggcgagagc gtgagcatca gctgccggag     2040

cagcaagagc ctgctgaaca gcaacggcaa cacctacctg tactggttcc tgcagcggcc     2100

aggccagagc ccccagctgc tgatctaccg gatgagcaac ctggccagcg gcgtgcccga     2160

ccggttcagc ggcagcggca gcggcaccgc cttcaccctg cggatcagcc gggtggaggc     2220

cgaggacgtg ggcgtgtact actgcatgca gcacctggag taccccttca ccttcggagc     2280

cggcaccaag ctggagctga agcggtcgga tcccaccacc accccagccc cacggccacc     2340

tacccctgcc ccaaccatcg ccagccagcc cctgagcctg cggcctgaag cctgcaggcc     2400

tgccgccgga ggagccgtgc acacaagggg cctggacttc gcctgcgaca tctatatctg     2460

ggcccccctg gccgggacat gcggggtgct gctgctgtcc ctggtgatta cactgtattg     2520

caaacggggc cggaagaagc tgctgtacat cttcaagcag cccttcatgc ggcccgtgca     2580

gaccacccag gaggaggacg gctgcagctg ccggttcccc gaggaagagg aaggcggctg     2640

cgagctgcgg gtgaagttca gccggagcgc cgacgcccca gcctaccagc agggccagaa     2700

ccagctgtac aacgagctga acctgggacg gcgggaggag tacgacgtgc tggacaagcg     2760

gcggggacgg gaccccgaga tgggcggcaa gcctcgccgg aagaatcccc aggagggcct     2820

gtacaacgag ctgcagaagg acaagatggc cgaggcctac agcgagatcg gcatgaaggg     2880

cgagcggcgc cggggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa     2940

ggacacctac gacgccctgc acatgcaggc cctgccaccc cggtgaacgc gtgccgctcc     3000

ggattagtcc aatttgttaa agacaggatt cgaggagctt gataattcca cggggttggg     3060

gttgcgcctt ttccaaggca gccctgggtt tgcgcaggga cgcggctgct ctgggcgtgg     3120

ttccgggaaa cgcagcggcg ccgaccctgg gtctcgcaca ttcttcacgt ccgttcgcag     3180

cgtcacccgg atcttcgccg ctacccttgt gggccccccg gcgacgcttc ctgctccgcc     3240

cctaagtcgg gaaggttcct tgcggttcgc ggcgtgccgg acgtgacaaa cggaagccgc     3300

acgtctcact agtaccctcg cagacggaca gcgccaggga gcaatggcag cgcgccgacc     3360

gcgatgggct gtggccaata gcggctgctc agcagggcgc gccgagagca gcggccggga     3420

aggggcggtg cgggaggcgg ggtgtggggc ggtagtgtgg gccctgttcc tgcccgcgcg     3480

gtgttccgca ttctgcaagc ctccggagcg cacgtcggca gtcggctccc tcgttgaccg     3540

aatcaccgac ctctctcccc agggggatca tcgaattcgc caacatgcgg ccgcgccacc     3600

atgaagacga tcatcgccct gagctacatc ttctgcctgg tattcgccga ctacaaggac     3660

gatgatgacg ccagcatcga tatgtataat ggctcctgtt gccggattga aggcgacact     3720

atctctcaag taatgccccc cctcctgata gtggccttcg tcctgggcgc tcttggtaat     3780

ggggttgcac tctgtggttt ctgtttccac atgaaaacct ggaagccctc aacagtgtac     3840

ctctttaacc ttgccgtggc agacttcctg cttatgattt gcctgccctt taggaccgac     3900

tattatctgc gacgccgcca ttgggctttc ggcgacatcc cctgtcgggt tggtctgttt     3960

actctggcta tgaatcgggc cggcagtatc gtctttctca ctgtggtcgc tgccgacaga     4020

tacttcaagg tagtgcaccc ccaccacgca gtgaacacaa tctccactag agttgcagct     4080

ggaattgtgt gcaccctgtg ggctctggta atcctgggca cagtatacct gctcctggag     4140

aatcatttgt gcgtgcagga gactgctgtg tcatgtgaat cttttattat ggagtccgca     4200

aacgggtggc atgatatcat gtttcaactg gagttcttta tgccccttgg catcattctg     4260

ttttgctcat tcaagatcgt ttggtctctc cggcgccggc agcagctggc ccggcaagct     4320

cggatgaaaa aggccacgcg ctttatcatg gttgtggcta tcgtcttcat cacctgctac     4380

cttccttccg tgtccgcaag actgtatttt ctgtggaccg tccccagcag cgcttgcgat     4440

cccagtgtcc acggcgccct ccacatcacc ttgagcttta cgtacatgaa ctctatgctg     4500

gaccccctgg tgtactattt tagctctccc tccttcccga aattctataa taaacttaag     4560

atctgcagcc tcaaaccaaa gcaaccaggc cattccaaga ctcagcgccc tgaagagatg     4620

cccattagca accttggtag acggagctgc atctccgtcg cgaactcatt tcagtctcag     4680

tccgacggac agtgggaccc acacattgtt gagtggcaca tcgataccgg tggacgcacc     4740

ccacccagcc tgggtcccca agatgagtcc tgcaccaccg ccagctcctc cctggccaag     4800

gacacttcat cgaccggtga gaacctgtac ttccagctaa gattagataa aagtaaagtg     4860

attaacagcg cattagagct gcttaatgag gtcggaatcg aaggtttaac aacccgtaaa     4920

ctcgcccaga agctaggtgt agagcagcct acattgtatt ggcatgtaaa aaataagcgg     4980

gctttgctcg acgccttagc cattgagatg ttagataggc accatactca cttttgccct     5040

ttagaagggg aaagctggca agatttttta cgtaataacg ctaaaagttt tagatgtgct     5100

ttactaagtc atcgcgatgg agcaaaagta catttaggta cacggcctac agaaaaacag     5160

tatgaaactc tcgaaaatca attagccttt ttatgccaac aaggtttttc actagagaat     5220

gcattatatg cactcagcgc tgtggggcat tttactttag gttgcgtatt ggaagatcaa     5280

gagcatcaag tcgctaaaga agaaagggaa acacctacta ctgatagtat gccgccatta     5340

ttacgacaag ctatcgaatt atttgatcac caaggtgcag agccagcctt cttattcggc     5400

cttgaattga tcatatgcgg attagaaaaa caacttaaat gtgaaagtgg gtccatggaa     5460

accgtgatta aagtgattag cagcgcgccg gtggtggcga tgccggtggt gattaaaacc     5520

gaaggcccgg cgtggacccc gctggaaccg gaagataccc gctggctgga tggcaaacat     5580

aaacgcaaaa gcagccagtg cctggtgaaa agcagcatga gcggctatat tccgagctgc     5640

ctggataaag atgaacagtg cgtggtgtgc ggcgataaac cgaccggcta tcattatcgc     5700

tgcattacct gcgaaggctg caaaagcttt tttcgccgca ccattcagaa aaacctgcat     5760

ccgacctata gctgcaccta tgatggctgc tgcgtgattg ataaaattac ccgcaaccag     5820

tgccagctgt gccgctttaa aaaatgcatt agcgtgggca tggcgatgga tctggtgctg     5880

gatgatagca aacgcgtggc gaaacgcaaa ctgattgaag aaaaccgcga acgccgccgc     5940

aaagaagaaa tgattaaaag cctgcagcat cgcccgagcc cgagcgcgga agaatgggaa     6000

ctgattcatg tggtgaccga agcgcatcgc agcaccaacg cgcagggcag ccattggaaa     6060

cagcgccgca aatttctgct ggaagatatt ggccagagcc cgatggcgag catgctggat     6120

ggcgataaag tggatctgga agcgtttacc gaatttacca aaattattac cccggcgatt     6180

acccgcgtgg tggattttgc gaaaaacctg ccgatgttta gcgaactgcc gtgcgaagat     6240

cagattattc tgctgaaagg ctgctgcatg gaaattatga gcctgcgcgc ggcggtgcgc     6300

tatgatccgg aaagcgaaac cctgaccctg agcggcgaaa tggcggtgaa acgcgaacag     6360

ctgaaaaacg gcggcctggg cgtggtgagc gatgcgattt ttgatctggg caaaagcctg     6420

agcgcgttta acctggatga taccgaagtg gcgctgctgc aggcggtgct gctgatgagc     6480

agcgatcgca ccggcctgat ttgcgtggat aaaattgaaa aatgccagga aagctatctg     6540

ctggcgtttg aacattatat taactatcgc aaacataaca ttccgcattt ttggagcaaa     6600

ctgctgatga aagtggcgga tctgcgcatg attggcgcgt atcatgcgag ccgctttctg     6660

catatgaaag tggaatgccc gaccgaactg agcccgcagg aagtgggccc ggatcattgc     6720

atgaaatgcg cgcattttat tgatggcccg cattgcgtga aagcgtgccc ggcgggcgtg     6780

ctgggcgaaa acgataccct ggtgtggaaa tatgcggatg cgaacgcggt gtgccagctg     6840

tgccatccga actgcacccg cggctgcaaa ggcccgggcc tggaaggctg cccgaacggc     6900

agcaaaaccc cgagcattgc ggcgggcgtg gtgggcggcc tgctgtgcct ggtggtggtg     6960

ggcctgggca ttggcctgta tctgcgccgc cgccatattg tgcgcaaacg caccctgcgc     7020

cgcctgctgc aggaacgcga actggtggaa ccgctgaccc cgagcggcga agcgccgaac     7080

caggcgcatc tgcgcattct gaaagaaacc gaatttaaaa aagtgaaagt gctgggcttt     7140

ggcgcgtttg gcaccgtgta taaaggcctg tggattccgg aaggcgaaaa agtgaccatt     7200

ccggtggcga ttaaagaact gcgcgaagcg accagcccga aagcgaacaa agaaattctg     7260

gatgaagcgt atgtgatggc gagcgtggat aacccgcatg tgtgccgcct gctgggcatt     7320

tgcctgacca gcaccgtgca gctgattacc cagctgatgc cgtatggctg cctgctggat     7380

tatattcgcg aacataaaga taacattggc agccagtatc tgctgaactg gtgcgtgcag     7440

attgcgaaag gcatgaacta tctggaagaa cgccatatgg tgcatcgcga tctggcggcg     7500

cgcaacgtgc tggtgaaaac cccgcagcat gtgaaaatta ccgattttgg cctggcgaaa     7560

cagctgggcg cggatgaaaa agaatatcat gcggaaggcg gcaaagtgcc gattaaatgg     7620

atggcgctgg aaagcattct gcatcgcatt tatacccatc agagcgatgt gtggagctat     7680

ggcgtgaccg tgtgggaact gatgaccttt ggcagcaaac cgtatgatgg cattccggcg     7740

agcgaaatta gcagcgtgct ggaaaaaggc gaacgcctgc cgcagccgcc gatttgcacc     7800

attgatgtgt atatgattat ggtgaaatgc tggatgagcg gcgcggatag ccgcccgaaa     7860

tttcgcgaac tgattgcgga atttagcaaa atggcgcgcg atccgccgcg ctatctggtg     7920

attcagggcg atgaacgcat gcatctgccg agcccgaccg atagcaaatt ttatcgcacc     7980

ctgatggaag aagaagatat ggaagatatt gtggatgcgg atgaatatct ggtgccgcat     8040

cagggctttt ttaacagccc gagcaccagc cgcaccccgc tgctgagcag cctgagcgcg     8100

accagcaaca acagcgcgac caaatgcatt gatcgcaacg gcggccatcc ggtgcgcgaa     8160

gatggctttc tgccggcgcc ggaatatgtg aaccagctga tgccgaaaaa accgagcacc     8220

gcgatggtgc agaaccagat ttataactat attagcctga ccgcgattag caaactgccg     8280

atggatagcc gctatcagaa cagccatagc accgcggtgg ataacccgga atatctggaa     8340

cagtgtacta attatgctct cttgaaattg gctggagatg tcgagtccaa ccctgggcca     8400

atgggtgaaa agccaggtac cagggtcttc aagaagtcga gccctaactg caagctcacc     8460

gtgtacttgg gcaagcggga cttcgtagat cacctggaca aagtggaccc tgtagatggc     8520

gtggtgcttg tggaccctga ctacctgaag gaccgcaaag tgtttgtgac cctcacctgc     8580

gccttccgct atggccgtga agacctggat gtgctgggct tgtccttccg caaagacctg     8640

ttcatcgcca cctaccaggc cttccccccg gtgcccaacc caccccggcc ccccacccgc     8700

ctgcaggacc ggctgctgag gaagctgggc cagcatgccc accccttctt cttcaccata     8760

ccccagaatc ttccatgctc cgtcacactg cagccaggcc cagaggatac aggaaaggcc     8820

tgcggcgtag actttgagat tcgagccttc tgtgctaaat cactagaaga gaaaagccac     8880

aaaaggaact ctgtgcggct ggtgatccga aaggtgcagt tcgccccgga gaaacccggc     8940

ccccagcctt cagccgaaac cacacgccac ttcctcatgt ctgaccgctc cctgcacctc     9000

gaggcttccc tggacaagga gctgtactac cacggggagc ccctcaatgt aaatgtccac     9060

gtcaccaaca actccaccaa gaccgtcaag aagatcaaag tctctgtgag acagtacgcc     9120

gacatctgcc tcttcagcac cgcccagtac aagtgtcctg tggctcaact cgaacaagat     9180

gaccaggtat ctcccagctc cacattctgt aaggtgtaca ccataacccc actgctcagt     9240

gacaaccggg agaagcgggg tctcgccctg gatgggaaac tcaagcacga ggacaccaac     9300

ctggcttcca gcaccatcgt gaaggagggt gccaacaagg aggtgctggg aatcctggtg     9360

tcctacaggg tcaaggtgaa gctggtggtg tctcgaggcg gggatgtctc tgtggagctg     9420

ccttttgttc ttatgcaccc caagccccac gaccacatcc ccctccccag accccagtca     9480

gccgctccgg agacagatgt ccctgtggac accaacctca ttgaatttga taccaactat     9540

gccacagatg atgacattgt gtttgaggac tttgcccggc ttcggctgaa ggggatgaag     9600

gatgacgact atgatgatca actctgcagc ttgtttaagg gaccacgtga ttacaacccg     9660

atatcgagca ccatttgtca tttgacgaat gaatctgatg ggcacacaac atcgttgtat     9720

ggtattggat ttggtccctt catcattaca aacaagcact tgtttagaag aaataatgga     9780

acactgttgg tccaatcact acatggtgta ttcaaggtca agaacaccac gactttgcaa     9840

caacacctca ttgatgggag ggacatgata attattcgca tgcctaagga tttcccacca     9900

tttcctcaaa agctgaaatt tagagagcca caaagggaag agcgcatatg tcttgtgaca     9960

accaacttcc aaactaagag catgtctagc atggtgtcag acactagttg cacattccct    10020

tcatctgatg gcatattctg gaagcattgg attcaaacca aggatgggca gtgtggcagt    10080

ccattagtat caactagaga tgggttcatt gttggtatac actcagcatc gaatttcacc    10140

aacacaaaca attatttcac aagcgtgccg aaaaacttca tggaattgtt gacaaatcag    10200

gaggcgcagc agtgggttag tggttggcga ttaaatgctg actcagtatt gtgggggggc    10260

cataaagttt tcatgagcaa acctgaagag ccttttcagc cagttaagga agcgactcaa    10320

ctcatgaatg aattggtgta ctcgcaatga ggatcccccg ggctgcagga attcgagcat    10380

cttaccgcca tttataccca tatttgttct gtttttcttg atttgggtat acatttaaat    10440

gttaataaaa caaaatggtg gggcaatcat ttacattttt agggatatgt aattactagt    10500

tcaggtgtat tgccacaaga caaacatgtt aagaaacttt cccgttattt acgctctgtt    10560

cctgttaatc aacctctgga ttacaaaatt tgtgaaagat tgactgatat tcttaactat    10620

gttgctcctt ttacgctgtg tggatatgct gctttaatgc ctctgtatca tgctattgct    10680

tcccgtacgg ctttcgtttt ctcctccttg tataaatcct ggttgctgtc tctttatgag    10740

gagttgtggc ccgttgtccg tcaacgtggc gtggtgtgct ctgtgtttgc tgacgcaacc    10800

cccactggct ggggcattgc caccacctgt caactccttt ctgggacttt cgctttcccc    10860

ctcccgatcg ccacggcaga actcatcgcc gcctgccttg cccgctgctg gacaggggct    10920

aggttgctgg gcactgataa ttccgtggtg ttgtcgggga agctgacgtc ctttcgaatt    10980

cgatatcaag cttaacacga gccatagata gaataaaaga ttttatttag tctccagaaa    11040

aaggggggaa tgaaagaccc caccgctagc gatatcgaat tcacaacccc tcactcggcg    11100

cgccagtcct ccgacagact gagtcgcccg ggtacccgtg ttctcaataa accctcttgc    11160

agttgcatcc gactcgtggt ctcgctgttc cttgggaggg tctcctctga gtgattgact    11220

gcccacctcg ggggtctt                                                  11238


