                         SEQUENCE LISTING

<110>  University of Sheffield
 
<120>  GENE THERAPY

<130>  4589P/WO

<150>  GB1609597.8
<151>  2016-06-01

<160>  158   

<170>  PatentIn version 3.5

<210>  1
<211>  747
<212>  DNA
<213>  homo sapiens

<400>  1
atgtcgggag gtggtgtgat tcgtggcccc gcagggaaca acgattgccg catctacgtg       60

ggtaacttac ctccagacat ccgaaccaag gacattgagg acgtgttcta caaatacggc      120

gctatccgcg acatcgacct caagaatcgc cgcgggggac cgcccttcgc cttcgttgag      180

ttcgaggacc cgcgagacgc ggaagacgcg gtgtatggtc gcgacggcta tgattacgat      240

gggtaccgtc tgcgggtgga gtttcctcga agcggccgtg gaacaggccg aggcggcggc      300

gggggtggag gtggcggagc tccccgaggt cgctatggcc ccccatccag gcggtctgaa      360

aacagagtgg ttgtctctgg actgcctcca agtggaagtt ggcaggattt aaaggatcac      420

atgcgtgaag caggtgatgt atgttatgct gatgtttacc gagatggcac tggtgtcgtg      480

gagtttgtac ggaaagaaga tatgacctat gcagttcgaa aactggataa cactaagttt      540

agatctcatg agggagaaac tgcctacatc cgggttaaag ttgatgggcc cagaagtcca      600

agttatggaa gatctcgatc tcgaagccgt agtcgtagca gaagccgtag cagaagcaac      660

agcaggagtc gcagttactc cccaaggaga agcagaggat caccacgcta ttctccccgt      720

catagcagat ctcgctctcg tacataa                                          747


<210>  2
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 
            180                 185                 190         


Lys Val Asp Gly Pro Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg 
        195                 200                 205             


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg 
    210                 215                 220                 


Ser Tyr Ser Pro Arg Arg Ser Arg Gly Ser Pro Arg Tyr Ser Pro Arg 
225                 230                 235                 240 


His Ser Arg Ser Arg Ser Arg Thr 
                245             


<210>  3
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtcgggag gtggtgtgat tcgtggcccc gcagggaaca acgattgccg catctacgtg       60

ggtaacttac ctccagacat ccgaaccaag gacattgagg acgtgttcta caaatacggc      120

gctatccgcg acatcgacct caagaatcgc cgcgggggac cgcccttcgc cttcgttgag      180

ttcgaggacc cgcgagacgc ggaagacgcg gtgtatggtc gcgacggcta tgattacgat      240

gggtaccgtc tgcgggtgga gtttcctcga agcggccgtg gaacaggccg aggcggcggc      300

gggggtggag gtggcggagc tccccgaggt cgctatggcc ccccatccag gcggtctgaa      360

aacagagtgg ttgtctctgg actgcctcca agtggaagtt ggcaggattt aaaggatcac      420

atgcgtgaag caggtgatgt atgttatgct gatgtttacc gagatggcac tggtgtcgtg      480

gagtttgtac ggaaagaaga tatgacctat gcagttcgaa aactggataa cactaagttt      540

agatctcatg aggtaggtta tacacgtatt cttttctttg accagaattg gatacagtgg      600

tcttaa                                                                 606


<210>  4
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Val Gly Tyr Thr Arg Ile Leu Phe 
            180                 185                 190         


Phe Asp Gln Asn Trp Ile Gln Trp Ser 
        195                 200     


<210>  5
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  5
aactgcctac atccgggtta a                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  6
ttaaagttga tgggcccaga a                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  7
gggcccagaa gtccaagtta t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  8
agcagaggat caccacgcta t                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  9
tcaataatgg aggcaatggt a                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  10
aatggtatga ctccaagtgc t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  11
gctaatttgt cacagtgctt a                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  12
gttaatgtgt gacctgctgt t                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  13
actgctaaat ctgcatgtcc t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  14
tgatagagcg ttgctatttc a                                                 21


<210>  15
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  antagonistic agent

<400>  15

Pro Arg Ser Gly Arg Gly Thr Gly Arg Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Ala Pro Arg Gly Arg Tyr Gly Pro Pro Ser Arg Arg Ser Glu 
            20                  25                  30          


<210>  16
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified protein

<400>  16

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Ala Ser Gly Ala Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Ala Ala Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 
            180                 185                 190         


Lys Val Asp Gly 
        195     


<210>  17
<211>  187
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified protein

<400>  17

Met Ala Gly Asn Asn Asp Cys Arg Ile Tyr Val Gly Asn Leu Pro Pro 
1               5                   10                  15      


Asp Ile Arg Thr Lys Asp Ile Glu Asp Val Phe Tyr Lys Tyr Gly Ala 
            20                  25                  30          


Ile Arg Asp Ile Asp Leu Lys Asn Arg Arg Gly Gly Pro Pro Phe Ala 
        35                  40                  45              


Phe Val Glu Phe Glu Asp Pro Arg Asp Ala Glu Asp Ala Val Tyr Gly 
    50                  55                  60                  


Arg Asp Gly Tyr Asp Tyr Asp Gly Tyr Arg Leu Arg Val Glu Phe Pro 
65                  70                  75                  80  


Ala Ser Gly Ala Gly Thr Gly Arg Gly Gly Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Ala Pro Arg Gly Arg Tyr Gly Pro Pro Ser Ala Ala Ser Glu Asn 
            100                 105                 110         


Arg Val Val Val Ser Gly Leu Pro Pro Ser Gly Ser Trp Gln Asp Leu 
        115                 120                 125             


Lys Asp His Met Arg Glu Ala Gly Asp Val Cys Tyr Ala Asp Val Tyr 
    130                 135                 140                 


Arg Asp Gly Thr Gly Val Val Glu Phe Val Arg Lys Glu Asp Met Thr 
145                 150                 155                 160 


Tyr Ala Val Arg Lys Leu Asp Asn Thr Lys Phe Arg Ser His Glu Gly 
                165                 170                 175     


Glu Thr Ala Tyr Ile Arg Val Lys Val Asp Gly 
            180                 185         


<210>  18
<211>  1968
<212>  DNA
<213>  homo sapiens

<400>  18
atggagcgga aagtgcttgc gctccaggcc cgaaagaaaa ggaccaaggc caagaaggac       60

aaagcccaaa ggaaatctga aactcagcac cgaggctctg ctccccactc tgagagtgat      120

ctaccagagc aggaagagga gattctggga tctgatgatg atgagcaaga agatcctaat      180

gattattgta aaggaggtta tcatcttgtg aaaattggag atctattcaa tgggagatac      240

catgtgatcc gaaagttagg ctggggacac ttttcaacag tatggttatc atgggatatt      300

caggggaaga aatttgtggc aatgaaagta gttaaaagtg ctgaacatta cactgaaaca      360

gcactagatg aaatccggtt gctgaagtca gttcgcaatt cagaccctaa tgatccaaat      420

agagaaatgg ttgttcaact actagatgac tttaaaatat caggagttaa tggaacacat      480

atctgcatgg tatttgaagt tttggggcat catctgctca agtggatcat caaatccaat      540

tatcaggggc ttccactgcc ttgtgtcaaa aaaattattc agcaagtgtt acagggtctt      600

gattatttac ataccaagtg ccgtatcatc cacactgaca ttaaaccaga gaacatctta      660

ttgtcagtga atgagcagta cattcggagg ctggctgcag aagcaacaga atggcagcga      720

tctggagctc ctccgccttc cggatctgca gtcagtactg ctccccagcc taaaccagct      780

gacaaaatgt caaagaataa gaagaagaaa ttgaagaaga agcagaagcg ccaggcagaa      840

ttactagaga agcgaatgca ggaaattgag gaaatggaga aagagtcggg ccctgggcaa      900

aaaagaccaa acaagcaaga agaatcagag agtcctgttg aaagaccctt gaaagagaac      960

ccacctaata aaatgaccca agaaaaactt gaagagtcaa gtaccattgg ccaggatcaa     1020

acgcttatgg aacgtgatac agagggtggt gcagcagaaa ttaattgcaa tggagtgatt     1080

gaagtcatta attatactca gaacagtaat aatgaaacat tgagacataa agaggatcta     1140

cataatgcta atgactgtga tgtccaaaat ttgaatcagg aatctagttt cctaagctcc     1200

caaaatggag acagcagcac atctcaagaa acagactctt gtacacctat aacatctgag     1260

gtgtcagaca ccatggtgtg ccagtcttcc tcaactgtag gtcagtcatt cagtgaacaa     1320

cacattagcc aacttcaaga aagcattcgg gcagagatac cctgtgaaga tgaacaagag     1380

caagaacata acggaccact ggacaacaaa ggaaaatcca cggctggaaa ttttcttgtt     1440

aatccccttg agccaaaaaa tgcagaaaag ctcaaggtga agattgctga ccttggaaat     1500

gcttgttggg tgcacaaaca tttcactgaa gatattcaaa caaggcaata tcgttccttg     1560

gaagttctaa tcggatctgg ctataatacc cctgctgaca tttggagcac ggcatgcatg     1620

gcctttgaac tggccacagg tgactatttg tttgaacctc attcagggga agagtacact     1680

cgagatgaag atcacattgc attgatcata gaacttctgg ggaaggtgcc tcgcaagctc     1740

attgtggcag gaaaatattc caaggaattt ttcaccaaaa aaggtgacct gaaacatatc     1800

acgaagctga aaccttgggg cctttttgag gttctagtgg agaagtatga gtggtcgcag     1860

gaagaggcag ctggcttcac agatttctta ctgcccatgt tggagctgat ccctgagaag     1920

agagccactg ccgccgagtg tctccggcac ccttggctta actcctaa                  1968


<210>  19
<211>  655
<212>  PRT
<213>  homo sapiens

<400>  19

Met Glu Arg Lys Val Leu Ala Leu Gln Ala Arg Lys Lys Arg Thr Lys 
1               5                   10                  15      


Ala Lys Lys Asp Lys Ala Gln Arg Lys Ser Glu Thr Gln His Arg Gly 
            20                  25                  30          


Ser Ala Pro His Ser Glu Ser Asp Leu Pro Glu Gln Glu Glu Glu Ile 
        35                  40                  45              


Leu Gly Ser Asp Asp Asp Glu Gln Glu Asp Pro Asn Asp Tyr Cys Lys 
    50                  55                  60                  


Gly Gly Tyr His Leu Val Lys Ile Gly Asp Leu Phe Asn Gly Arg Tyr 
65                  70                  75                  80  


His Val Ile Arg Lys Leu Gly Trp Gly His Phe Ser Thr Val Trp Leu 
                85                  90                  95      


Ser Trp Asp Ile Gln Gly Lys Lys Phe Val Ala Met Lys Val Val Lys 
            100                 105                 110         


Ser Ala Glu His Tyr Thr Glu Thr Ala Leu Asp Glu Ile Arg Leu Leu 
        115                 120                 125             


Lys Ser Val Arg Asn Ser Asp Pro Asn Asp Pro Asn Arg Glu Met Val 
    130                 135                 140                 


Val Gln Leu Leu Asp Asp Phe Lys Ile Ser Gly Val Asn Gly Thr His 
145                 150                 155                 160 


Ile Cys Met Val Phe Glu Val Leu Gly His His Leu Leu Lys Trp Ile 
                165                 170                 175     


Ile Lys Ser Asn Tyr Gln Gly Leu Pro Leu Pro Cys Val Lys Lys Ile 
            180                 185                 190         


Ile Gln Gln Val Leu Gln Gly Leu Asp Tyr Leu His Thr Lys Cys Arg 
        195                 200                 205             


Ile Ile His Thr Asp Ile Lys Pro Glu Asn Ile Leu Leu Ser Val Asn 
    210                 215                 220                 


Glu Gln Tyr Ile Arg Arg Leu Ala Ala Glu Ala Thr Glu Trp Gln Arg 
225                 230                 235                 240 


Ser Gly Ala Pro Pro Pro Ser Gly Ser Ala Val Ser Thr Ala Pro Gln 
                245                 250                 255     


Pro Lys Pro Ala Asp Lys Met Ser Lys Asn Lys Lys Lys Lys Leu Lys 
            260                 265                 270         


Lys Lys Gln Lys Arg Gln Ala Glu Leu Leu Glu Lys Arg Met Gln Glu 
        275                 280                 285             


Ile Glu Glu Met Glu Lys Glu Ser Gly Pro Gly Gln Lys Arg Pro Asn 
    290                 295                 300                 


Lys Gln Glu Glu Ser Glu Ser Pro Val Glu Arg Pro Leu Lys Glu Asn 
305                 310                 315                 320 


Pro Pro Asn Lys Met Thr Gln Glu Lys Leu Glu Glu Ser Ser Thr Ile 
                325                 330                 335     


Gly Gln Asp Gln Thr Leu Met Glu Arg Asp Thr Glu Gly Gly Ala Ala 
            340                 345                 350         


Glu Ile Asn Cys Asn Gly Val Ile Glu Val Ile Asn Tyr Thr Gln Asn 
        355                 360                 365             


Ser Asn Asn Glu Thr Leu Arg His Lys Glu Asp Leu His Asn Ala Asn 
    370                 375                 380                 


Asp Cys Asp Val Gln Asn Leu Asn Gln Glu Ser Ser Phe Leu Ser Ser 
385                 390                 395                 400 


Gln Asn Gly Asp Ser Ser Thr Ser Gln Glu Thr Asp Ser Cys Thr Pro 
                405                 410                 415     


Ile Thr Ser Glu Val Ser Asp Thr Met Val Cys Gln Ser Ser Ser Thr 
            420                 425                 430         


Val Gly Gln Ser Phe Ser Glu Gln His Ile Ser Gln Leu Gln Glu Ser 
        435                 440                 445             


Ile Arg Ala Glu Ile Pro Cys Glu Asp Glu Gln Glu Gln Glu His Asn 
    450                 455                 460                 


Gly Pro Leu Asp Asn Lys Gly Lys Ser Thr Ala Gly Asn Phe Leu Val 
465                 470                 475                 480 


Asn Pro Leu Glu Pro Lys Asn Ala Glu Lys Leu Lys Val Lys Ile Ala 
                485                 490                 495     


Asp Leu Gly Asn Ala Cys Trp Val His Lys His Phe Thr Glu Asp Ile 
            500                 505                 510         


Gln Thr Arg Gln Tyr Arg Ser Leu Glu Val Leu Ile Gly Ser Gly Tyr 
        515                 520                 525             


Asn Thr Pro Ala Asp Ile Trp Ser Thr Ala Cys Met Ala Phe Glu Leu 
    530                 535                 540                 


Ala Thr Gly Asp Tyr Leu Phe Glu Pro His Ser Gly Glu Glu Tyr Thr 
545                 550                 555                 560 


Arg Asp Glu Asp His Ile Ala Leu Ile Ile Glu Leu Leu Gly Lys Val 
                565                 570                 575     


Pro Arg Lys Leu Ile Val Ala Gly Lys Tyr Ser Lys Glu Phe Phe Thr 
            580                 585                 590         


Lys Lys Gly Asp Leu Lys His Ile Thr Lys Leu Lys Pro Trp Gly Leu 
        595                 600                 605             


Phe Glu Val Leu Val Glu Lys Tyr Glu Trp Ser Gln Glu Glu Ala Ala 
    610                 615                 620                 


Gly Phe Thr Asp Phe Leu Leu Pro Met Leu Glu Leu Ile Pro Glu Lys 
625                 630                 635                 640 


Arg Ala Thr Ala Ala Glu Cys Leu Arg His Pro Trp Leu Asn Ser 
                645                 650                 655 


<210>  20
<211>  1933
<212>  DNA
<213>  Homo sapiens

<400>  20
gtgcatgacc cgccccgcgg cggagacgcg ctcgctgcgt catcagtgtt ttcgagacga       60

gtctcgacgc agcagctgtc agctccattt tgttgttggt gcgcgacgca gtcagctgcg      120

tgattcccgt gattgcgtta caagctttgt ctccttcgac ttggagtctt tgtccaggac      180

gatgagacac tcaaagagaa cttactgtcc tgattgggat gacaaggatt gggattatgg      240

aaaatggagg agcagcagca gtcataaaag aaggaagaga tcacatagca gtgcccagga      300

gaacaagcgc tgcaaataca atcactctaa aatgtgtgat agccattatt tggaaagcag      360

gtctataaat gagaaagatt atcatagtcg acgctacatt gatgagtaca gaaatgacta      420

cactcaagga tgtgaacctg gacatcgcca aagagaccat gaaagccggt atcagaacca      480

tagtagcaag tcttctggta gaagtggaag aagtagttat aaaagcaaac acaggattca      540

ccacagtact tcacatcgtc gttcacatgg gaagagtcac cgaaggaaaa gaaccaggag      600

tgtagaggat gatgaggagg gtcacctgat ctgtcagagt ggagacgtac taagtgcaag      660

atatgaaatt gttgatactt taggtgaagg agcttttgga aaagttgtgg agtgcatcga      720

tcataaagcg ggaggtagac atgtagcagt aaaaatagtt aaaaatgtgg atagatactg      780

tgaagctgct cgctcagaaa tacaagttct ggaacatctg aatacaacag accccaacag      840

tactttccgc tgtgtccaga tgttggaatg gtttgagcat catggtcaca tttgcattgt      900

ttttgaacta ttgggactta gtacttacga cttcattaaa gaaaatggtt ttctaccatt      960

tcgactggat catatcagaa agatggcata tcagatatgc aagtctgtga attttttgca     1020

cagtaataag ttgactcaca cagacttaaa gcctgaaaac atcttatttg tgcagtctga     1080

ctacacagag gcgtataatc ccaaaataaa acgtgatgaa cgcaccttaa taaatccaga     1140

tattaaagtt gtagactttg gtagtgcaac atatgatgac gaacatcaca gtacattggt     1200

atctacaaga cattatagag cacctgaagt tattttagcc ctagggtggt cccaaccatg     1260

tgatgtctgg agcataggat gcattcttat tgaatactat cttgggttta ccgtatttcc     1320

aacacacgat agtaaggagc atttagcaat gatggaaagg attcttggac ctctaccaaa     1380

acatatgata cagaaaacca ggaaacgtaa atattttcac cacgatcgat tagactggga     1440

tgaacacagt tctgccggca gatatgtttc aagacgctgt aaacctctga aggaatttat     1500

gctttctcaa gatgttgaac atgagcgtct ctttgacctc attcagaaaa tgttggagta     1560

tgatccagcc aaaagaatta ctctcagaga agccttaaag catcctttct ttgaccttct     1620

gaagaaaagt atatagatct gtaattggac agctctctcg aagagatctt acagactgta     1680

tcagtctaat ttttaaattt taagttattt tgtacagctt tgtaaattct taacattttt     1740

atattgccat gtttattttg tttgggtaat ttggttcatt aagtacatag ctaaggtaat     1800

gaacatcttt ttcagtaatt gtaaagtgat ttattcagaa taaatttttt gtgcttatga     1860

agttgatatg tatctgaaca gtttgttcta agtaccattt ttcttcctac ttctattaaa     1920

gaatggacat aga                                                        1933


<210>  21
<211>  484
<212>  PRT
<213>  homo sapiens

<400>  21

Met Arg His Ser Lys Arg Thr Tyr Cys Pro Asp Trp Asp Asp Lys Asp 
1               5                   10                  15      


Trp Asp Tyr Gly Lys Trp Arg Ser Ser Ser Ser His Lys Arg Arg Lys 
            20                  25                  30          


Arg Ser His Ser Ser Ala Gln Glu Asn Lys Arg Cys Lys Tyr Asn His 
        35                  40                  45              


Ser Lys Met Cys Asp Ser His Tyr Leu Glu Ser Arg Ser Ile Asn Glu 
    50                  55                  60                  


Lys Asp Tyr His Ser Arg Arg Tyr Ile Asp Glu Tyr Arg Asn Asp Tyr 
65                  70                  75                  80  


Thr Gln Gly Cys Glu Pro Gly His Arg Gln Arg Asp His Glu Ser Arg 
                85                  90                  95      


Tyr Gln Asn His Ser Ser Lys Ser Ser Gly Arg Ser Gly Arg Ser Ser 
            100                 105                 110         


Tyr Lys Ser Lys His Arg Ile His His Ser Thr Ser His Arg Arg Ser 
        115                 120                 125             


His Gly Lys Ser His Arg Arg Lys Arg Thr Arg Ser Val Glu Asp Asp 
    130                 135                 140                 


Glu Glu Gly His Leu Ile Cys Gln Ser Gly Asp Val Leu Ser Ala Arg 
145                 150                 155                 160 


Tyr Glu Ile Val Asp Thr Leu Gly Glu Gly Ala Phe Gly Lys Val Val 
                165                 170                 175     


Glu Cys Ile Asp His Lys Ala Gly Gly Arg His Val Ala Val Lys Ile 
            180                 185                 190         


Val Lys Asn Val Asp Arg Tyr Cys Glu Ala Ala Arg Ser Glu Ile Gln 
        195                 200                 205             


Val Leu Glu His Leu Asn Thr Thr Asp Pro Asn Ser Thr Phe Arg Cys 
    210                 215                 220                 


Val Gln Met Leu Glu Trp Phe Glu His His Gly His Ile Cys Ile Val 
225                 230                 235                 240 


Phe Glu Leu Leu Gly Leu Ser Thr Tyr Asp Phe Ile Lys Glu Asn Gly 
                245                 250                 255     


Phe Leu Pro Phe Arg Leu Asp His Ile Arg Lys Met Ala Tyr Gln Ile 
            260                 265                 270         


Cys Lys Ser Val Asn Phe Leu His Ser Asn Lys Leu Thr His Thr Asp 
        275                 280                 285             


Leu Lys Pro Glu Asn Ile Leu Phe Val Gln Ser Asp Tyr Thr Glu Ala 
    290                 295                 300                 


Tyr Asn Pro Lys Ile Lys Arg Asp Glu Arg Thr Leu Ile Asn Pro Asp 
305                 310                 315                 320 


Ile Lys Val Val Asp Phe Gly Ser Ala Thr Tyr Asp Asp Glu His His 
                325                 330                 335     


Ser Thr Leu Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile Leu 
            340                 345                 350         


Ala Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile 
        355                 360                 365             


Leu Ile Glu Tyr Tyr Leu Gly Phe Thr Val Phe Pro Thr His Asp Ser 
    370                 375                 380                 


Lys Glu His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Leu Pro Lys 
385                 390                 395                 400 


His Met Ile Gln Lys Thr Arg Lys Arg Lys Tyr Phe His His Asp Arg 
                405                 410                 415     


Leu Asp Trp Asp Glu His Ser Ser Ala Gly Arg Tyr Val Ser Arg Arg 
            420                 425                 430         


Cys Lys Pro Leu Lys Glu Phe Met Leu Ser Gln Asp Val Glu His Glu 
        435                 440                 445             


Arg Leu Phe Asp Leu Ile Gln Lys Met Leu Glu Tyr Asp Pro Ala Lys 
    450                 455                 460                 


Arg Ile Thr Leu Arg Glu Ala Leu Lys His Pro Phe Phe Asp Leu Leu 
465                 470                 475                 480 


Lys Lys Ser Ile 
                


<210>  22
<211>  1367
<212>  DNA
<213>  Homo sapiens

<400>  22
gggcaaggag ctgctggctg gacggcggca tgtccgacag cgagaagctc aacctggact       60

cgatcatcgg gcgcctgctg gaagtgcagg gctcgcggcc tggcaagaat gtacagctga      120

cagagaacga gatccgcggt ctgtgcctga aatcccggga gatttttctg agccagccca      180

ttcttctgga gctggaggca cccctcaaga tctgcggtga catacacggc cagtactacg      240

accttctgcg actatttgag tatggcggtt tccctcccga gagcaactac ctctttctgg      300

gggactatgt ggacaggggc aagcagtcct tggagaccat ctgcctgctg ctggcctata      360

agatcaagta ccccgagaac ttcttcctgc tccgtgggaa ccacgagtgt gccagcatca      420

accgcatcta tggtttctac gatgagtgca agagacgcta caacatcaaa ctgtggaaaa      480

ccttcactga ctgcttcaac tgcctgccca tcgcggccat agtggacgaa aagatcttct      540

gctgccacgg aggcctgtcc ccggacctgc agtctatgga gcagattcgg cggatcatgc      600

ggcccacaga tgtgcctgac cagggcctgc tgtgtgacct gctgtggtct gaccctgaca      660

aggacgtgca gggctggggc gagaacgacc gtggcgtctc ttttaccttt ggagccgagg      720

tggtggccaa gttcctccac aagcacgact tggacctcat ctgccgagca caccaggtgg      780

tagaagacgg ctatgagttc tttgccaagc ggcagctggt gacacttttc tcagctccca      840

actactgtgg cgagtttgac aatgctggcg ccatgatgag tgtggacgag accctcatgt      900

gctctttcca gatcctcaag cccgccgaca agaacaaggg gaagtacggg cagttcagtg      960

gcctgaaccc tggaggccga cccatcaccc caccccgcaa ttccgccaaa gccaagaaat     1020

agcccccgca caccaccctg tgccccagat gatggattga ttgtacagaa atcatgctgc     1080

catgctgggg gggggtcacc ccgaccccta aggcccacct gtcacgggga acatggagcc     1140

ttggtgtatt tttcttttct ttttttaatg aatcaatagc agcgtccagt cccccagggc     1200

tgcttcctgc ctgcacctgc ggtactgtga gcaggatcct ggggccgagg ctgcagctca     1260

gggcaacggc aggccaggtc gtgggtctcc agccgtgctt ggcctcaggc tggcagcccg     1320

gatcctgggg caacccatct ggtctcttga ataaaggtca aagctgg                   1367


<210>  23
<211>  4747
<212>  DNA
<213>  Homo sapiens

<400>  23
gttgcgctcc cgcgcgtgcg tgttgggatc gaatcgctgt ttccttccgc ttctcttcct       60

ctgtctcccc cccatatccg tgcgccgagc tgataaaggc gccattttgg aggggccgcg      120

ggagacgtgg tgccgctgcg ggctcgctct gccgtgcgct aggcttggtg ggaaggcctg      180

ttctcgagtc cgcgcttttc gtcaccgcca tgtcgggagg tggtgtgatt cgtggccccg      240

cagggaacaa cgattgccgc atctacgtgg gtaacttacc tccagacatc cgaaccaagg      300

acattgagga cgtgttctac aaatacggcg ctatccgcga catcgacctc aagaatcgcc      360

gcgggggacc gcccttcgcc ttcgttgagt tcgaggaccc gcgagacgcg gaagacgcgg      420

tgtatggtcg cgacggctat gattacgatg ggtaccgtct gcgggtggag tttcctcgaa      480

gcggccgtgg aacaggccga ggcggcggcg ggggtggagg tggcggagct ccccgaggtc      540

gctatggccc cccatccagg cggtctgaaa acagagtggt tgtctctgga ctgcctccaa      600

gtggaagttg gcaggattta aaggatcaca tgcgtgaagc aggtgatgta tgttatgctg      660

atgtttaccg agatggcact ggtgtcgtgg agtttgtacg gaaagaagat atgacctatg      720

cagttcgaaa actggataac actaagttta gatctcatga ggtaggttat acacgtattc      780

ttttctttga ccagaattgg atacagtggt cttaacagtg gaatttcaag gtaaggattc      840

aggcaaggtt gtccaagtaa attgccagat ttctggtttt agttacattg tattcattca      900

gcatgtctga agatagatga aagcttagat ctttcaatgg aaagttctgt ctatccaata      960

gggagaaact gcctacatcc gggttaaagt tgatgggccc agaagtccaa gttatggaag     1020

atctcgatct cgaagccgta gtcgtagcag aagccgtagc agaagcaaca gcaggagtcg     1080

cagttactcc ccaaggagaa gcagaggatc accacgctat tctccccgtc atagcagatc     1140

tcgctctcgt acataagatg attggtgaca ctttttgtag aacccatgtt gtatacagtt     1200

ttcctttatt cagtacaatc ttttcatttt ttaattcaaa ctgttttgtt cagaatgggc     1260

taaagtgttg aattgcattc ttgtaatatc cccttgctcc taacatctac attcccttcg     1320

tgtctttgat aaattgtatt ttaagtgatg tcatagacag gattgtttaa atttagttaa     1380

ctccatactc ttcagactgt gatattgtgt aaatgtctat ctgccctggt ttgtgtgaac     1440

tgggatgttg ggggtgtttg tggttatctt acctggggaa gttcttatgt ttatcttgct     1500

tttcatgtgt ctttctgtag acatatctga agagatggat taagaatgct ttggattaag     1560

gattgtggag cacatttcaa tcattttagg attgtcaaaa ggaggattga ggaggatcag     1620

atcaataatg gaggcaatgg tttggattgg agagggctca ctggatccca atccttggag     1680

ctggatcatt ggattcaaat cataatgtgg ataggatagg gaggatgaat taccaggatt     1740

catggagcgg gatcagatta ccaggaacat aggagtggat tcctgcccca accaaaccgc     1800

attcgtgtgg atttttttat tcaacttaat tggctattcc aaagattttt tttttcctat     1860

ttttgacgat tggagccctt aagatgcacg atggaattgt gttttgcgtt ttttggtaaa     1920

aggagcaaag cgaggacctg gagataaacg ctggagcaat ctccttggaa ggattcagca     1980

cgagtagatg gtaaacattt aaaggggaaa gggggggttt gtttaaaata gtaaatcagt     2040

aagtcacttc taaatttaaa gaaaacaaaa ttggagttga agaataagta ggtttccaat     2100

tggctattgc cgttttcttt gaaaaaataa acatttttta aaaaactatg catggttgtc     2160

ctttttcctc ttcatgtaag attctaactg ggtctatcag ttaatcttta aattgttaag     2220

taagataaga ttttgactct tgtgttaatg tgttagcaaa ttaaaagttc ttaaaaggca     2280

atctaatggt attagccatc ttttattgtt aattgtaaaa gtcttcaggg gaaagcaaaa     2340

ggggagaata aggcatttgt gtatgtaact tggtaaatga cggtggggga tggatctagc     2400

atctgaaaga taagcttctc tactttgtta taaagtggtt aaaaaactat agatgctgct     2460

tattttctgg tggtcataga caacataggc ttttgtgcaa aattggttga tggctactaa     2520

tgttcacttg gagatagctt ttgatattct caatgaaact catctcaaaa aaaggtaagt     2580

attaaatgtt aacatcagca cagatgtatt agaactgttt tttgtttttg agacagagtc     2640

tcgctctgtt ctccagactg gagggcagtg gtgtgatcta ggctcactgc aacctccacc     2700

cctggatttg agtgattctc gtgcctcagt ctcccaagta gctgagacta caagtgtgtg     2760

ccacccttgc ccggctaatt ttgtattttt agtagagatg tggtttctct gtgttaccca     2820

ggctggtccc aaaactcctg gcctcaagtg atctgcctgc cttggcctcc caaagtgtta     2880

ggattacagg tgtgagccac catgctcagc ctgtagaact tttaacccaa gtctcatttc     2940

ttttttgaaa gggaagagtg cacaagatta actgcttctt tggatgaatc attgttaata     3000

aaaagctggg catttagaat tttgccttat aagcccttct ccaaccataa gattattttg     3060

taccaaaaac tttggtgttc tctaccaaag cagttaaaaa cttttagcct gctacttctt     3120

gtatttgtct actgacagcc ccttggtact atttaggttg ggggagggga cctaaaataa     3180

atagacttta acatttccct tgggtgctaa tcatagttgg aagttgaatt taaggtgatt     3240

atttgggtga caattaaaaa cctaaggaaa accagaaatc ttggtagtgg aagaaatgtg     3300

taaggtcacc ccaatcggta gattttaatg aacgttgtgg aatgttggga agaggggatg     3360

ttaagttgaa tgcagaattt cactaagtac ttagtgtaag tttaaggatg tagctctttt     3420

tatctaagaa ttcaatgtaa tggccaaaag gcagatttac tgtttaaaaa tttgaataat     3480

tttacatgac attcttgaaa ttctaagaag ttttatgtgt agaacatttt aaaaattcat     3540

cagattatta aagggaaaat aaatgattaa tgataatttt ggaaggttaa tgtgagctag     3600

acttaagtaa actttggttc atttgtgttc attgaatgtt ttggaaatga ccaaaaaatg     3660

taaatggcct tcactcaagt ttgagtgttt aaagttgaaa gatgtgctct actaaaagtt     3720

atagtaattc taacctcaca ttgaaatgag acagtattcc ttgttataca ggctgaattt     3780

gaagattaga gaggatctaa tgtttactta ggtaaagggg cataggtttt gtagttaaga     3840

tgaccagaca gctaaaagct gtgatgggaa gtatggactg ctcctattta tagtctcaga     3900

aaatggacct ttaggtctct atccgtattg gcaattatta gaagaaagtt acaccctttt     3960

gaaactacaa aagctgtctt ggaatttccc cctcttctcc ctatttatgt ccccttagaa     4020

tattttaggg agcctataat tattttctaa ccaaggaaaa acttaagtct ctttaagaag     4080

caattacttt tcataacatc agattgaata acccaccttg ctgttcagcc cacatcctac     4140

tggaaacaaa aggtaagaaa cccattttct ggttcttgat tgtttgggtc tgaattttgt     4200

ttttaaaact aagctaagtt taatgttttt taaaatgctg tttggaatat gaatagattc     4260

cccgtaaaat gatttttcct aagttttatg ctttagtaaa tattcagtgc tcacgtctgt     4320

gcatcatagt gcttgcgttt aatatgattt attgtagaat ctcaactttt cttggtgttt     4380

gttgtctttg aaacattgtc ttggtcatta gggctggtgt tttcacattt ctgtggtcaa     4440

ggtggatttc ttatgtgtgc ctttttgctt actttgtata tgaattttgt aatttaaatt     4500

gcaagtaagt tatatatatg tatttaccat aaatagtatt aaaagatgag aaactgttag     4560

actgaagttc tgttgtaaca taaccattat ttccatcaca gtatgaagac tgcaaacgca     4620

gaaaacagat tacagtctct tatccatttt ttgaaatcca aaaactacga aaacaaaaga     4680

ttttctgttg ttgagctaat taaatgtgaa ccctgaccag aaaaaaaaaa aaaaaaaaaa     4740

aaaaaaa                                                               4747


<210>  24
<211>  747
<212>  DNA
<213>  Mus musulus

<400>  24
atgtcgggag gtggtgtgat ccgtggcccg gcggggaaca acgactgccg catctacgtg       60

ggtaacctac ctccggatat ccgaaccaag gacatcgagg acgtgtttta caaatacggc      120

gccatccgcg acatcgacct gaagaaccgc cgcgggggac cgcccttcgc cttcgttgag      180

ttcgaggacc cgcgagacgc ggaagatgcg gtgtacggtc gcgacggcta cgactacgac      240

ggctaccggc tgcgggtaga gtttccccga agcggccgcg ggaccggccg aggcggcggc      300

gggggtggag gcggcggcgc cccgagaggc cgctatggcc cgccgtccag gcggtccgag      360

aacagagtgg ttgtctctgg actgcctccg agtggaagct ggcaggactt aaaggatcac      420

atgcgtgagg caggtgatgt atgttacgct gatgtttacc gagatggcac tggtgtcgtg      480

gagtttgtac ggaaagaaga tatgacgtat gcagttcgaa aactggataa cactaagttt      540

agatctcacg agggagaaac tgcctacatc cgggttaaag ttgatgggcc cagaagtcca      600

agttatggaa gatctcgatc tcgaagccgt agtcgtagca gaagccgtag cagaagcaac      660

agcaggagtc gcagttactc cccaaggaga agcagaggat caccacgcta ttctccccgt      720

catagcagat ctcgctctcg tacataa                                          747


<210>  25
<211>  248
<212>  PRT
<213>  Mus musulus

<400>  25

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 
            180                 185                 190         


Lys Val Asp Gly Pro Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg 
        195                 200                 205             


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg 
    210                 215                 220                 


Ser Tyr Ser Pro Arg Arg Ser Arg Gly Ser Pro Arg Tyr Ser Pro Arg 
225                 230                 235                 240 


His Ser Arg Ser Arg Ser Arg Thr 
                245             


<210>  26
<211>  747
<212>  DNA
<213>  Mus musculus

<400>  26
atgtcgggag gtggtgtgat ccgtggcccg gcggggaaca acgactgccg catctacgtg       60

ggtaacctac ctccggatat ccgaaccaag gacatcgagg acgtgtttta caaatacggc      120

gccatccgcg acatcgacct gaagaaccgc cgcgggggac cgcccttcgc cttcgttgag      180

ttcgaggacc cgcgagacgc ggaagatgcg gtgtacggtc gcgacggcta cgactacgac      240

ggctaccggc tgcgggtaga gtttccccga agcggccgcg ggaccggccg aggcggcggc      300

gggggtggag gcggcggcgc cccgagaggc cgctatggcc cgccgtccag gcggtccgag      360

aacagagtgg ttgtctctgg actgcctccg agtggaagct ggcaggactt aaaggatcac      420

atgcgtgagg caggtgatgt atgttacgct gatgtttacc gagatggcac tggtgtcgtg      480

gagtttgtac ggaaagaaga tatgacgtat gcagttcgaa aactggataa cactaagttt      540

agatctcacg agggagaaac tgcctacatc cgggttaaag ttgatgggcc cagaagtcca      600

agttatggaa gatctcgatc tcgaagccgt agtcgtagca gaagccgtag cagaagcaac      660

agcaggagtc gcagttactc cccaaggaga agcagaggat caccacgcta ttctccccgt      720

catagcagat ctcgctctcg tacataa                                          747


<210>  27
<211>  248
<212>  PRT
<213>  Mus musulus

<400>  27

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 
            180                 185                 190         


Lys Val Asp Gly Pro Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg 
        195                 200                 205             


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg 
    210                 215                 220                 


Ser Tyr Ser Pro Arg Arg Ser Arg Gly Ser Pro Arg Tyr Ser Pro Arg 
225                 230                 235                 240 


His Ser Arg Ser Arg Ser Arg Thr 
                245             


<210>  28
<211>  606
<212>  DNA
<213>  Mus musulus

<400>  28
atgtcgggag gtggtgtgat ccgtggcccg gcggggaaca acgactgccg catctacgtg       60

ggtaacctac ctccggatat ccgaaccaag gacatcgagg acgtgtttta caaatacggc      120

gccatccgcg acatcgacct gaagaaccgc cgcgggggac cgcccttcgc cttcgttgag      180

ttcgaggacc cgcgagacgc ggaagatgcg gtgtacggtc gcgacggcta cgactacgac      240

ggctaccggc tgcgggtaga gtttccccga agcggccgcg ggaccggccg aggcggcggc      300

gggggtggag gcggcggcgc cccgagaggc cgctatggcc cgccgtccag gcggtccgag      360

aacagagtgg ttgtctctgg actgcctccg agtggaagct ggcaggactt aaaggatcac      420

atgcgtgagg caggtgatgt atgttacgct gatgtttacc gagatggcac tggtgtcgtg      480

gagtttgtac ggaaagaaga tatgacgtat gcagttcgaa aactggataa cactaagttt      540

agatctcacg aggtaggtta tacacttatt cttttttttg gccagaattg gatacagttt      600

tcttaa                                                                 606


<210>  29
<211>  201
<212>  PRT
<213>  Mus musulus

<400>  29

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Val Gly Tyr Thr Leu Ile Leu Phe 
            180                 185                 190         


Phe Gly Gln Asn Trp Ile Gln Phe Ser 
        195                 200     


<210>  30
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Val Gln Gly Ser Arg Pro Gly Lys Asn Val Gln Leu Thr Glu 
            20                  25                  30          


Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser 
        35                  40                  45              


Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp 
    50                  55                  60                  


Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly 
65                  70                  75                  80  


Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg 
                85                  90                  95      


Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile 
            100                 105                 110         


Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala 
        115                 120                 125             


Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr 
    130                 135                 140                 


Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro 
145                 150                 155                 160 


Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu 
                165                 170                 175     


Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro 
            180                 185                 190         


Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp 
        195                 200                 205             


Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser 
    210                 215                 220                 


Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp 
225                 230                 235                 240 


Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu 
                245                 250                 255     


Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr 
            260                 265                 270         


Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr 
        275                 280                 285             


Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly 
    290                 295                 300                 


Lys Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile Thr 
305                 310                 315                 320 


Pro Pro Arg Asn Ser Ala Lys Ala Lys Lys 
                325                 330 


<210>  31
<211>  659
<212>  DNA
<213>  Homo sapiens

<400>  31
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggccccccc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggaaaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcg       659


<210>  32
<211>  724
<212>  DNA
<213>  Homo sapiens

<400>  32
acgcgttgac attgattatt gactagttat taatagtaat caattacggg gtcattagtt       60

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga      120

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca      180

atagggactt tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca      240

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg      300

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc      360

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt      420

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt      480

ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg      540

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tctctggcta      600

actagagaac ccactgctta ctggcttatc gaaattaata cgactcacta tagggagacc      660

caagctggct agcgtttaaa cttaagcttg gtaccgagct cggatccact agtccagtgt      720

ggtg                                                                   724


<210>  33
<211>  278
<212>  DNA
<213>  Homo sapiens

<400>  33
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

ggcccccccc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggaaaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg                              278


<210>  34
<211>  401
<212>  DNA
<213>  Homo sapiens

<400>  34
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc g                          401


<210>  35
<211>  1675
<212>  DNA
<213>  Homo sapiens

<400>  35
gtctgcaagc agacctggca gcattgggct ggccgccccc cagggcctcc tcttcatgcc       60

cagtgaatga ctcaccttgg cacagacaca atgttcgggg tgggcacagt gcctgcttcc      120

cgccgcaccc cagcccccct caaatgcctt ccgagaagcc cattgagtag ggggcttgca      180

ttgcacccca gcctgacagc ctggcatctt gggataaaag cagcacagcc ccctaggggc      240

tgcccttgct gtgtggcgcc accggcggtg gagaacaagg ctctattcag cctgtgccca      300

ggaaagggga tcaggggatg cccaggcatg gacagtgggt ggcagggggg gagaggaggg      360

ctgtctgctt cccagaagtc caaggacaca aatgggtgag gggactgggc agggttctga      420

ccctgtggga ccagagtgga gggcgtagat ggacctgaag tctccaggga caacagggcc      480

caggtctcag gctcctagtt gggcccagtg gctccagcgt ttccaaaccc atccatcccc      540

agaggttctt cccatctctc caggctgatg tgtgggaact cgaggaaata aatctccagt      600

gggagacgga ggggtggcca gggaaacggg gcgctgcagg aataaagacg agccagcaca      660

gccagctcat gcgtaacggc tttgtggagc tgtcaaggcc tggtctctgg gagagaggca      720

cagggaggcc agacaaggaa ggggtgacct ggagggacag atccaggggc taaagtcctg      780

ataaggcaag agagtgccgg ccccctcttg ccctatcagg acctccactg ccacatagag      840

gccatgattg acccttagac aaagggctgg tgtccaatcc cagcccccag ccccagaact      900

ccagggaatg aatgggcaga gagcaggaat gtgggacatc tgtgttcaag ggaaggactc      960

caggagtctg ctgggaatga ggcctagtag gaaatgaggt ggcccttgag ggtacagaac     1020

aggttcattc ttcgccaaat tcccagcacc ttgcaggcac ttacagctga gtgagataat     1080

gcctgggtta tgaaatcaaa aagttggaaa gcaggtcaga ggtcatctgg tacagccctt     1140

ccttcccttt tttttttttt tttttttttg tgagacaagg tctctctctg ttgcccaggc     1200

tggagtggcg caaacacagc tcactgcagc ctcaacctac tgggctcaag caatcctcca     1260

gcctcagcct cccaaagtgc tgggattaca agcatgagcc accccactca gccctttcct     1320

tcctttttaa ttgatgcata ataattgtaa gtattcatca tggtccaacc aaccctttct     1380

tgacccacct tcctagagag agggtcctct tgattcagcg gtcagggccc cagacccatg     1440

gtctggctcc aggtaccacc tgcctcatgc aggagttggc gtgcccagga agctctgcct     1500

ctgggcacag tgacctcagt ggggtgaggg gagctctccc catagctggg ctgcggccca     1560

accccacccc ctcaggctat gccagggggt gttgccaggg gcacccgggc atcgccagtc     1620

tagcccactc cttcataaag ccctcgcatc ccaggagcga gcagagccag agcat          1675


<210>  36
<211>  260
<212>  DNA
<213>  Homo sapiens

<400>  36
gaatcctatg cttcgaacgc tgacgtcatc aacccgctcc aaggaatcgc gggcccagtg       60

tcactaggcg ggaacaccca gcgcgcgtgc gccctggcag gaagatggct gtgagggaca      120

ggggagtggc gccctgcaat atttgcatgt cgctatgtgt tctgggaaat caccataaac      180

gtgaaatgtc tttggatttg ggagtcttat aagttctgta tgagaccact ctttcccatg      240

gtcttcatcc tatctagaca                                                  260


<210>  37
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  37
gccgccccct tcaccgaggg cctatttccc atgattcctt catatttgca tatacgatac       60

aaggctgtta gagagataat tggaattaat ttgactgtaa acacaaagat attagtacaa      120

aatacgtgac gtagaaagta ataatttctt gggtagtttg cagttttaaa attatgtttt      180

aaaatggact atcatatgct taccgtaact tgaaagtatt tcgatttctt ggctttatat      240

atcttgtgga aaggacgaaa c                                                261


<210>  38
<211>  4661
<212>  DNA
<213>  Adenovirus

<400>  38
aaagcttccc ggggggatct gggccactcc ctctctgcgc gctcgctcgc tcactgaggc       60

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg      120

agcgcgcaga gagggagtgg ccaactccat cactaggggt tcctggaggg gtggagtcgt      180

gacccctaaa atgggcaaac attgcgctag cgcggccgcg gtacctaccg atgtacgggc      240

cagatatacg cgtggagcta gttattaata gtaatcaatt acggggtcat tagttcatag      300

cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc      360

caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg      420

gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca      480

tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc      540

ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt      600

attagtcatc gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata      660

gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt      720

ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca      780

aatgggcggt aggcgtgtac ggtgggaggt ctatataagc agagctcgtt tagtgaaccg      840

tcagatcgcc tggagacgcc atccacgctg ttttgacctc catagaagac accgggaccg      900

atccagcctg aattctgcag tcgacggtac cgcgggcccg ggatccaccg gtcgccacca      960

tggtgagcaa gggcgaggag ctgttcaccg gggtggtgcc catcctggtc gagctggacg     1020

gcgacgtaaa cggccacaag ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg     1080

gcaagctgac cctgaagttc atctgcacca ccggcaagct gcccgtgccc tggcccaccc     1140

tcgtgaccac cctgacctac ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc     1200

agcacgactt cttcaagtcc gccatgcccg aaggctacgt ccaggagcgc accatcttct     1260

tcaaggacga cggcaactac aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg     1320

tgaaccgcat cgagctgaag ggcatcgact tcaaggagga cggcaacatc ctggggcaca     1380

agctggagta caactacaac agccacaacg tctatatcat ggccgacaag cagaagaacg     1440

gcatcaaggt gaacttcaag atccgccaca acatcgagga cggcagcgtg cagctcgccg     1500

accactacca gcagaacacc cccatcggcg acggccccgt gctgctgccc gacaaccact     1560

acctgagcac ccagtccgcc ctgagcaaag accccaacga gaagcgcgat cacatggtcc     1620

tgctggagtt cgtgaccgcc gccgggatca ctctcggcat ggacgagctg tacaagtaaa     1680

gcggccgcga ctctagagtc gacctgcagg gaagaccaag ctgacctgac tcgatgcttt     1740

atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa     1800

gttaacaaca acaattgcat tcattttatg tttcaggttc agggggaggt gtgggaggtt     1860

ttttaaacta gtccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa     1920

aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag     1980

agggacagat ccgggcccgc atgcgtcgac aattcactgg ccgtcgtttt acaacgtcgt     2040

gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc     2100

agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg     2160

aatggcgaat ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac     2220

cgcatatggt gcactctcag tacaatctgc tctgatgccg catagttaag ccagccccga     2280

cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac     2340

agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg     2400

aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata     2460

ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt     2520

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa     2580

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt     2640

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa     2700

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac     2760

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt     2820

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt     2880

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat     2940

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac     3000

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg     3060

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc     3120

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa     3180

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag     3240

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct     3300

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat     3360

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa     3420

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     3480

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     3540

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     3600

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     3660

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     3720

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     3780

aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     3840

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     3900

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     3960

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     4020

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     4080

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     4140

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     4200

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     4260

ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg     4320

gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag     4380

cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc gcctctcccc     4440

gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc     4500

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac     4560

tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt tcacacagga     4620

aacagctatg accatgatta cgccaagctc tcgagatcta g                         4661


<210>  39
<211>  7390
<212>  DNA
<213>  Adenovirus

<400>  39
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacgg gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggccct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccgcggga tcgagccgac tttgccaaac tggttcgcgg tcacaaagac cagaaatggc      420

gccggaggcg ggaacaaggt ggtggatgag tgctacatcc ccaattactt gctccccaaa      480

acccagcctg agctccagtg ggcgtggact aatatggaac agtatttaag cgcctgtttg      540

aatctcacgg agcgtaaacg gttggtggcg cagcatctga cgcacgtgtc gcagacgcag      600

gagcagaaca aagagaatca gaatcccaat tctgatgcgc cggtgatcag atcaaaaact      660

tcagccaggt acatggagct ggtcgggtgg ctcgtggaca aggggattac ctcggagaag      720

cagtggatcc aggaggacca ggcctcatac atctccttca atgcggcctc caactcgcgg      780

tcccaaatca aggtgccttg gacaatgcgg gaaagattat gagcctgact aaaaccgccc      840

ccgactacct ggtgggccag cagcccgtgg aggacatttc cagcaatcgg atttataaaa      900

ttttggaact aaacgggtac gatccccaat atgcggcttc cgtctttctg ggatgggcca      960

cgaaaaagtt cggcaagagg aacaccatct ggctgtttgg gcctgcaact accgggaaga     1020

ccaacatcgc ggaggccata gcccacactg tgcccttcta cgggtgcgta aactggacca     1080

atgagaactt tcccttcaac gactgtgtcg acaagatggt gatctggtgg gaggagggga     1140

agatgaccgc caaggtcgtg gagtcggcca aagccattct cggaggaagc aaggtgcgcg     1200

tggaccagaa atgcaagtcc tcggcccaga tagacccgac tcccgtgatc gtcacctcca     1260

acaccaacat gtgcgccgtg attgacggga actcaacgac cttcgaacac cagcagccgt     1320

tgcaagaccg gatgttcaaa tttgaactca cccgccgtct ggatcatgac tttgggaagg     1380

tcaccaagca ggaagtcaaa gactttttcc ggtgggcaaa ggatcacgtg gttgaggtgg     1440

agcatgaatt ctacgtcaaa aagggtggag ccaagaaaag acccgccccc agtgacgcag     1500

atataagtga gcccaaacgg gtgcgcgagt cagttgcgca gccatcgacg tcagacgcgg     1560

aagcttcgat caactacgcg gacaggtacc aaaacaaatg ttctcgtcac gtgggcatga     1620

atctgatgct gtttccctgc agacaatgcg agagactgaa tcagaattca aatatctgct     1680

tcactcacgg tgtcaaagac tgtttagagt gctttcccgt gtcagaatct caacccgttt     1740

ctgtcgtcaa aaaggcgtat cagaaactgt gctacattca tcacatcatg ggaaaggtgc     1800

cagacgcttg cactgcttgc gacctggtca atgtggactt ggatgactgt gtttctgaac     1860

aataaatgac ttaaaccagg tatggctgcc gatggttatc ttccagattg gctcgaggac     1920

aaccttagtg aaggaattcg cgagtggtgg gctttgaaac ctggagcccc tcaacccaag     1980

gcaaatcaac aacatcaaga caacgctcga ggtcttgtgc ttccgggtta caaatacctt     2040

ggacccggca acggactcga caagggggag ccggtcaacg cagcagacgc ggcggccctc     2100

gagcacgaca aggcctacga ccagcagctc aaggccggag acaacccgta cctcaagtac     2160

aaccacgccg acgccgagtt ccaggagcgg ctcaaagaag atacgtcttt tgggggcaac     2220

ctcgggcgag cagtcttcca ggccaaaaag aggcttcttg aacctcttgg tctggttgag     2280

gaagcggcta agacggctcc tggaaagaag aggcctgtag agcagtctcc tcaggaaccg     2340

gactcctccg cgggtattgg caaatcgggt gcacagcccg ctaaaaagag actcaatttc     2400

ggtcagactg gcgacacaga gtcagtccca gaccctcaac caatcggaga acctcccgca     2460

gccccctcag gtgtgggatc tcttacaatg gcttcaggtg gtggcgcacc agtggcagac     2520

aataacgaag gtgccgatgg agtgggtagt tcctcgggaa attggcattg cgattcccaa     2580

tggctggggg acagagtcat caccaccagc acccgaacct gggccctgcc cacctacaac     2640

aatcacctct acaagcaaat ctccaacagc acatctggag gatcttcaaa tgacaacgcc     2700

tacttcggct acagcacccc ctgggggtat tttgacttca acagattcca ctgccacttc     2760

tcaccacgtg actggcagcg actcatcaac aacaactggg gattccggcc taagcgactc     2820

aacttcaagc tcttcaacat tcaggtcaaa gaggttacgg acaacaatgg agtcaagacc     2880

atcgccaata accttaccag cacggtccag gtcttcacgg actcagacta tcagctcccg     2940

tacgtgctcg ggtcggctca cgagggctgc ctcccgccgt tcccagcgga cgttttcatg     3000

attcctcagt acgggtatct gacgcttaat gatggaagcc aggccgtggg tcgttcgtcc     3060

ttttactgcc tggaatattt cccgtcgcaa atgctaagaa cgggtaacaa cttccagttc     3120

agctacgagt ttgagaacgt acctttccat agcagctacg ctcacagcca aagcctggac     3180

cgactaatga atccactcat cgaccaatac ttgtactatc tctcaaagac tattaacggt     3240

tctggacaga atcaacaaac gctaaaattc agtgtggccg gacccagcaa catggctgtc     3300

cagggaagaa actacatacc tggacccagc taccgacaac aacgtgtctc aaccactgtg     3360

actcaaaaca acaacagcga atttgcttgg cctggagctt cttcttgggc tctcaatgga     3420

cgtaatagct tgatgaatcc tggacctgct atggccagcc acaaagaagg agaggaccgt     3480

ttctttcctt tgtctggatc tttaattttt ggcaaacaag gaactggaag agacaacgtg     3540

gatgcggaca aagtcatgat aaccaacgaa gaagaaatta aaactactaa cccggtagca     3600

acggagtcct atggacaagt ggccacaaac caccagagtg cccaagcaca ggcgcagacc     3660

ggctgggttc aaaaccaagg aatacttccg ggtatggttt ggcaggacag agatgtgtac     3720

ctgcaaggac ccatttgggc caaaattcct cacacggacg gcaactttca cccttctccg     3780

ctgatgggag ggtttggaat gaagcacccg cctcctcaga tcctcatcaa aaacacacct     3840

gtacctgcgg atcctccaac ggccttcaac aaggacaagc tgaactcttt catcacccag     3900

tattctactg gccaagtcag cgtggagatc gagtgggagc tgcagaagga aaacagcaag     3960

cgctggaacc cggagatcca gtacacttcc aactattaca agtctaataa tgttgaattt     4020

gctgttaata ctgaaggtgt atatagtgaa ccccgcccca ttggcaccag atacctgact     4080

cgtaatctgt aattgcttgt taatcaataa accgtttaat tcgtttcagt tgaactttgg     4140

tctctgcgaa gggcgaattc gtttaaacct gcaggactag aggtcctgta ttagaggtca     4200

cgtgagtgtt ttgcgacatt ttgcgacacc atgtggtcac gctgggtatt taagcccgag     4260

tgagcacgca gggtctccat tttgaagcgg gaggtttgaa cgcgcagccg ccaagccgaa     4320

ttctgcagat atccatcaca ctggcggccg ctcgactaga gcggccgcca ccgcggtgga     4380

gctccagctt ttgttccctt tagtgagggt taattgcgcg cttggcgtaa tcatggtcat     4440

agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata cgagccggaa     4500

gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta attgcgttgc     4560

gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc     4620

aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact     4680

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     4740

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     4800

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     4860

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     4920

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     4980

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac     5040

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     5100

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     5160

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     5220

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagga     5280

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     5340

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     5400

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     5460

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     5520

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     5580

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     5640

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     5700

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     5760

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     5820

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     5880

ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt     5940

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     6000

tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     6060

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     6120

ccgtaagatg ctttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat     6180

gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag     6240

aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt     6300

accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc     6360

ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa     6420

gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg     6480

aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa     6540

taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctaaat tgtaagcgtt     6600

aatattttgt taaaattcgc gttaaatttt tgttaaatca gctcattttt taaccaatag     6660

gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg gttgagtgtt     6720

gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt caaagggcga     6780

aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc aagttttttg     6840

gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg atttagagct     6900

tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc     6960

gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt     7020

aatgcgccgc tacagggcgc gtcccattcg ccattcaggc tgcgcaactg ttgggaaggg     7080

cgatcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg tgctgcaagg     7140

cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac gacggccagt     7200

gagcgcgcgt aatacgactc actatagggc gaattgggta ccgggccccc cctcgatcga     7260

ggtcgacggt atcgggggag ctcggatcca ctagtaacgg ccgccagtgt gctggattcg     7320

gctttattta agcccgagtg agcacgcagg gtctccattt tgaagcggga ggtttgaacg     7380

cgcagccgcc                                                            7390


<210>  40
<211>  479
<212>  DNA
<213>  artificial sequence

<220>
<223>  RAN-G4C2x38 sense-repeats

<400>  40
cttatcgaaa ttaatacgac tcactatagg gagacccaag ctggctagtt aagcttggta       60

ccgagctcgg atccactagt ccagtgtggt ggaattgggg cccggggccg gggccggggc      120

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      180

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      240

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      300

cggggccggg gccggggccg gggccggggc cggggaattc tgcagatatc cagcacagtg      360

gcggccgctc gagtctagag ggcccttcga acaaaaactc atctcagaag aggatctgaa      420

tatgcatacc ggtcatcatc accatcacca ttgagtttaa acccgctgat cagcctcga       479


<210>  41
<211>  478
<212>  DNA
<213>  artificial sequence

<220>
<223>  RAN-C4G2x39 antisense-repeats:

<400>  41
cttatcgaaa ttaatacgac tcactatagg gagacccaag ctggctagtt aagcttggta       60

ccgagctcgg atccactagt ccagtgtggt ggaattcccc ggccccggcc ccggccccgg      120

ccccggcccc ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg      180

ccccggcccc ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg      240

ccccggcccc ggccccggcc ccggccccgg ccccggcccc ggccccggcc ccggccccgg      300

ccccggcccc ggccccggcc ccggccccgg ccccaattct gcagatatcc agcacagtgg      360

cggccgctcg agtctagagg gcccttcgaa caaaaactca tctcagaaga ggatctgaat      420

atgcataccg gtcatcatca ccatcaccat tgagtttaaa cccgctgatc agcctcga        478


<210>  42
<211>  285
<212>  DNA
<213>  artificial sequence

<220>
<223>  poly-Gly-Pro x36 DPRs independent of G4C2 repeats

<400>  42
atgggcaaac cgattccgaa cccgctgctg ggcctggata gcaccctcga gaatgatccc       60

accatgggcc ctggccctgg accaggacct ggccccggac ccggtccagg tcccggccca      120

ggccccggtc ccggccctgg accaggccca ggaccaggac caggcccagg tcccggacca      180

ggacccggac ctggcccagg ccctggccct ggccctggcc ccggaccagg ccctggaccc      240

ggccctggtc ccggcccagg acccggacca ggacctggcc cttaa                      285


<210>  43
<211>  285
<212>  DNA
<213>  artificial sequence

<220>
<223>  poly-Gly-Ala x36 DPRs independent of G4C2 repeats

<400>  43
atgggcaaac cgattccgaa cccgctgctg ggcctggata gcaccctcga gaatgatccc       60

accatgggag ctggtgctgg tgcaggcgct ggcgcagggg caggcgctgg tgctggggct      120

ggtgccgggg ctggggcagg cgcaggggct ggtgccggtg caggcgcagg ggctggggct      180

ggcgctggtg ccggcgcagg cgcgggtgcc ggcgcagggg ctggtgcagg ggccggtgct      240

ggcgcgggtg caggggccgg tgcaggggca ggcgcaggcg cttaa                      285


<210>  44
<211>  634
<212>  DNA
<213>  artificial sequence

<220>
<223>  RAN-G4C2x38 sense-repeats with 3x V5 tags

<400>  44
cttatcgaaa ttaatacgac tcactatagg gagacccaag ctggctagtt aagcttggta       60

ccgagctcgg atccactagt ccagtgtggt ggaattgggg cccggggccg gggccggggc      120

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      180

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      240

cggggccggg gccggggccg gggccggggc cggggccggg gccggggccg gggccggggc      300

cggggccggg gccggggccg gggccggggc cggggaattc tgcagatatc cagcacagtg      360

gcggccgctg ggcaagccca tccccaaccc cctgctcggt ctggacagca ccggctaacg      420

gcaagcccat ccccaacccc ctgctcggtc tggacagcac cggctaacgg caagcccatc      480

cccaaccccc tgctcggtct ggacagcacc ggctaactcg agtctagatc tagagggccc      540

ttcgaacaaa aactcatctc agaagaggat ctgaatatgc ataccggtca tcatcaccat      600

caccattgag tttaaacccg ctgatcagcc tcga                                  634


<210>  45
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  45
ttctgggccc atcaacttta a                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  46
agcacttgga gtcataccat t                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  47
gggatcgaat cgctgtttcc t                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  48
gctgtttcct tccgcttctc t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  49
gggcccagaa gtccaagtta t                                                 21


<210>  50
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  50
gctgatgttt accgagatgg c                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  51
aatgtctatt ctgctctggt t                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  52
aaattgcaga tgggagcaat a                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  53
ttgcagatgg gagcaatagt t                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  54
tgggagcaat agtttaggtt t                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  55
ttaggtttag gtgggtagta a                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  56
taggtttagg tgggtagtaa t                                                 21


<210>  57
<211>  359
<212>  DNA
<213>  artificial sequence

<220>
<223>  inverted repeat sequence

<400>  57
atgccgacga tgcggtgaag gcgcgcgacg gctacgacta cgatgggtat cgtctgcgcg       60

tggagttccc gcggggcggt ggtcctggaa gctaccgcgg cggcaaccgc aatgaccgaa      120

gccgcgacgg tgggggacgg atgggcggac gcggaccgcc agccaagcgc tcgcagtacc      180

gcgtcatggt tactggactg cccgcctccg gatcgtggca agatctcaag gatcacatgc      240

gcgaggccgg cgacgtctgc ttcgcggaca cttacaagga tggttccggc gtcgttgagt      300

tcctgcgcca cgaggacatg aagtacgcaa tcaaaaaatt ggacgactct cgcttccga       359


<210>  58
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  FlyBase ID = FBst0450381

<400>  58
ggtccgataa agaaggcggc agtgcactac gatcgctccg gtcgctcgtt gggcaccgct       60

gacgtgattt tcgaacgtcg cgccgacgcc ttgaaggcca ttaaacagta ccatggcgta      120

cctttggacg gacgccctat gaccattcag ctggccgtct cagacgtggc cgtgttgacc      180

cgtcccgtag ccgccaccga tgtcaagcgt cgcgtgggtg gtactgcacc aacttcattc      240

aagcgtggtg gtggccaagc tggtggcacg gcgcgtcgcg gcttcaaacg tccggtcggt      300

ggcaagccgg cggcaggcgg ccagcgacgg gagcgcaagg ccccgcccac tgctgaggag      360

ctggacgccg aactggactc a                                                381


<210>  59
<211>  324
<212>  DNA
<213>  artificial sequence

<220>
<223>  FlyBase ID = FBst0476329

<400>  59
gtcgaacttg ataaagcgca tttctaaata caataaatac agcatcaaat gtatttcagt       60

tatcttaaca tccgccgcat tggcaaaact aacaattaat ggataaatgc gcaagtggtt      120

gattgatttg atgtccgatg ctttcaaaga tctgctcctg ggcgcggcgt tgtcgatgcg      180

tttgcattta tgtaccatgc ggggggtgtc catatggtag gcttaaaact atagattggg      240

ctgctcttct attcttgtta gactaattca gactattcac tatttagatc ttcatgtcgt      300

tgatgtatga gtccagttcg gcgt                                             324


<210>  60
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  60
gcatctgaaa gataagcttc t                                                 21


<210>  61
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  human/mouse SRSF1 - miR1 -Top strand

<400>  61
tgctgttctg ggcccatcaa ctttaagttt tggccactga ctgacttaaa gtttgggccc       60

agaa                                                                    64


<210>  62
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  human/mouse/rat SRSF1 - miR1 - Bottom strand:

<400>  62
cctgttctgg gcccaaactt taagtcagtc agtggccaaa acttaaagtt gatgggccca       60

gaac                                                                    64


<210>  63
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  human SRSF1 - miR2 - Top strand

<400>  63
tgctgagcac ttggagtcat accattgttt tggccactga ctgacaatgg tatctccaag       60

tgct                                                                    64


<210>  64
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  human SRSF1 - miR2 - Bottom strand

<400>  64
cctgagcact tggagatacc attgtcagtc agtggccaaa acaatggtat gactccaagt       60

gctc                                                                    64


<210>  65
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Targeted mouse SRSF1 miR2 sequence

<400>  65
aatgtctatt ctgctctggt t                                                 21


<210>  66
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Targeted mouse SRSF1 miR2 sequence

<400>  66
aatgtctatt ctgctctggt t                                                 21


<210>  67
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  mouse SRSF1 - miR2 - Top strand

<400>  67
tgctgaacca gagcagaata gacattgttt tggccactga ctgacaatgt ctactgctct       60

ggtt                                                                    64


<210>  68
<211>  64
<212>  DNA
<213>  artificial sequence

<220>
<223>  mouse SRSF1 - miR2 - Bottom strand

<400>  68
cctgaaccag agcagtagac attgtcagtc agtggccaaa acaatgtcta ttctgctctg       60

gttc                                                                    64


<210>  69
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  hexanucleotide sense GGGGCCx38

<400>  69
ggggcc                                                                   6


<210>  70
<211>  6
<212>  DNA
<213>  artificial sequence

<220>
<223>  hexanucleotide antisense CCCCGGx39

<400>  70
ccccgg                                                                   6


<210>  71
<211>  12
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotides

<400>  71
ccccggcccc gg                                                           12


<210>  72
<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  72
actctagagg taccacgtga tcattctcga gggtgctatc caggc                       45


<210>  73
<211>  45
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  73
gcctggatag caccctcgag aatgatcacg tggtacctct agagt                       45


<210>  74
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  74
taccgcgtca tggttactgg                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  75
gtacgcgaat gtaggcaacc                                                   20


<210>  76
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  76
cgatatgtac gacggaccga a                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  77
cggaccaaag tcgttgaaga g                                                 21


<210>  78
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  78
tgggcccgtc tggaccacaa                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  79
tcgccgtcac cggagtccat                                                   20


<210>  80
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  80
ttccaaccta tggaactgat ga                                                22


<210>  81
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  81
ggttttcctc attaaaggca ttc                                               23


<210>  82
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  82
ccgcatctac gtgggtaact                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  83
tcgaactcaa cgaaggcgaa                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  84
tctggtcgca gcttaggaac                                                   20


<210>  85
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  85
ccacctctgt ttacgctctg t                                                 21


<210>  86
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  86
ccatgatcac gaaggtggtt                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  87
atgcagtcga gtttcccaca                                                   20


<210>  88
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  88
cttgtgaaac aaaatgcttt ttaacatcca t                                      31


<210>  89
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  89
gaatgtgagc accttccttc ttttt                                             25


<210>  90
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  90
gaactgcaca bccagaacac                                                   20


<210>  91
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  91
tgggttgaag ttgctgagg                                                    19


<210>  92
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  92
gggcccttcg aacccccgtc                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  93
gggaggggca aacaacagat                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  94
tcaaacagcg acaagttccg                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  95
gtcgacatga ctgcattcca                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  96
ggagagaggg tgggaaaaac                                                   20


<210>  97
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  97
gcatctacgt gggtaactta c                                                 21


<210>  98
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  98
ggaacaacga ttgccgcatc t                                                 21


<210>  99
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  99
ggagtttgta cggaaagaag a                                                 21


<210>  100
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  100
ggaagttggc aggatttaaa g                                                 21


<210>  101
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  101
ggtaggttat acacgtattc t                                                 21


<210>  102
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  102
gcaggtgatg tatgttatgc t                                                 21


<210>  103
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  103
gctgatgttt accgagatgg c                                                 21


<210>  104
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  104
gaagttggca ggatttaaag g                                                 21


<210>  105
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  105
gaaagaagat atgacctatg c                                                 21


<210>  106
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  106
gcgtgaagca ggtgatgtat g                                                 21


<210>  107
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  107
gtaagttacc cacgtagatg c                                                 21


<210>  108
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  108
taagtta                                                                  7


<210>  109
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  109
agatgcggca atcgttgttc c                                                 21


<210>  110
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  110
gatgcgg                                                                  7


<210>  111
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  111
tcttctttcc gtacaaactc c                                                 21


<210>  112
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  112
cttcttt                                                                  7


<210>  113
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  113
ctttaaatcc tgccaacttc c                                                 21


<210>  114
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  114
tttaaat                                                                  7


<210>  115
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  115
agaatacgtg tataacctac c                                                 21


<210>  116
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  116
gaatacg                                                                  7


<210>  117
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  117
agcataacat acatcacctg c                                                 21


<210>  118
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  118
gcataac                                                                  7


<210>  119
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  119
gccatctcgg taaacatcag c                                                 21


<210>  120
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  120
ccatctc                                                                  7


<210>  121
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  121
cctttaaatc ctgccaactt c                                                 21


<210>  122
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  122
ctttaaa                                                                  7


<210>  123
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  123
gcataggtca tatcttcttt c                                                 21


<210>  124
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  124
cataggt                                                                  7


<210>  125
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  125
catacatcac ctgcttcacg c                                                 21


<210>  126
<211>  7
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  126
atacatc                                                                  7


<210>  127
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  127
gcgctatccg cgacatcgac ct                                                22


<210>  128
<211>  7
<212>  RNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  128
ggucgau                                                                  7


<210>  129
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  129
tggccccgca gggaacaacg at                                                22


<210>  130
<211>  7
<212>  RNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  130
ucguugu                                                                  7


<210>  131
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  131
tcgcgacggc tatgattacg at                                                22


<210>  132
<211>  7
<212>  RNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  132
ucguaau                                                                  7


<210>  133
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  133
cggcgctatc cgcgacatcg ac                                                22


<210>  134
<211>  7
<212>  RNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  134
ucgaugu                                                                  7


<210>  135
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  135
agggaacaac gattgccgca tc                                                22


<210>  136
<211>  7
<212>  RNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  136
augcggc                                                                  7


<210>  137
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  137
gcggtgtatg gtcgcgacgg ct                                                22


<210>  138
<211>  7
<212>  RNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  138
gccgucg                                                                  7


<210>  139
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  139
ctgcgggtgg agtttcctcg aa                                                22


<210>  140
<211>  7
<212>  RNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  140
ucgagga                                                                  7


<210>  141
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  141
gtggagtttc ctcgaagcgg cc                                                22


<210>  142
<211>  7
<212>  RNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  142
gccgcuu                                                                  7


<210>  143
<211>  214
<212>  DNA
<213>  artificial sequence

<220>
<223>  promoter

<400>  143
gaacgctgac gtcatcaacc cgctccaagg aatcgcgggc ccagtgtcac taggcgggaa       60

cacccagcgc ggtgcgccct ggcaggaaga tggctgtgag ggacagggga gtggcgccct      120

gcaatatttg catgtcgcta tgtgttctgg gaaatcacca taaacgtgaa atgtctttgg      180

atttgggaat cttataagtt ctgtatgaga ccac                                  214


<210>  144
<211>  91
<212>  DNA
<213>  artificial sequence

<220>
<223>  promoter

<400>  144
atatttgcat gtcgctatgt gttctgggaa atcaccataa acgtgaaatg tctttggatt       60

tgggaatctt ataagttctg tatgagacca c                                      91


<210>  145
<211>  241
<212>  DNA
<213>  artificial sequence

<220>
<223>  promoter

<400>  145
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

c                                                                      241


<210>  146
<211>  278
<212>  DNA
<213>  artificial sequence

<220>
<223>  promoter

<400>  146
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg                              278


<210>  147
<211>  659
<212>  DNA
<213>  artificial sequence

<220>
<223>  promoter

<400>  147
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggccccccc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggaaaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcg       659


<210>  148
<211>  500
<212>  DNA
<213>  artificial sequence

<220>
<223>  promoter

<400>  148
gggtagggga ggcgcttttc ccaaggcagt ctggagcatg cgctttagca gccccgctgg       60

gcacttggcg ctacacaagt ggcctctggc ctcgcacaca ttccacatcc accggtaggc      120

gccaaccggc tccgttcttt ggtggcccct tcgcgccacc ttctactcct cccctagtca      180

ggaagttccc ccccgccccg cagctcgcgt cgtgcaggac gtgacaaatg gaagtagcac      240

gtctcactag tctcgtgcag atggacagca ccgctgagca atggaagcgg gtaggccttt      300

ggggcagcgg ccaatagcag ctttgctcct tcgctttctg ggctcagagg ctgggaaggg      360

gtgggtccgg gggcgggctc aggggcgggc tcaggggcgg ggcgggcgcc cgaaggtcct      420

ccggaggccc ggcattctgc acgcttcaaa agcgcacgtc tgccgcgctg ttctcctctt      480

cctcatctcc gggcctttcg                                                  500


<210>  149
<211>  212
<212>  DNA
<213>  artificial sequence

<220>
<223>  promoter

<400>  149
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgat       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  150
<211>  380
<212>  DNA
<213>  artificial sequence

<220>
<223>  promoter

<400>  150
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  151
<211>  204
<212>  DNA
<213>  artificial sequence

<220>
<223>  promoter

<400>  151
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  152
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  152

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Ala Ser Gly Ala Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Ala Ala Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 
            180                 185                 190         


Lys Val Asp Gly Pro Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg 
        195                 200                 205             


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg 
    210                 215                 220                 


Ser Tyr Ser Pro Arg Arg Ser Arg Gly Ser Pro Arg Tyr Ser Pro Arg 
225                 230                 235                 240 


His Ser Arg Ser Arg Ser Arg Thr 
                245             


<210>  153
<211>  61
<212>  PRT
<213>  artificial sequence

<220>
<223>  antagonistic peptide

<400>  153

Pro Arg Ser Gly Arg Gly Thr Gly Arg Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Ala Pro Arg Gly Arg Tyr Gly Pro Pro Ser Arg Arg Ser Glu 
            20                  25                  30          


Gly Gly Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
        35                  40                  45              


Gly Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
    50                  55                  60      


<210>  154
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  154
ggaaagaaga tatgacctat g                                                 21


<210>  155
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  155
agggagaaac tgcctacatc c                                                 21


<210>  156
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  156
gggactaatg tgggaagaac t                                                 21


<210>  157
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  157
gcaaccacga aacctgtaat a                                                 21


<210>  158
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  inhibitory RNA

<400>  158
gggatcagat taccaggaac a                                                 21


